CYP8B1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7-alpha,12-alpha-dihydroxy-4-cholesten-3-one. The balance between these two steroids determines the relative amounts of cholic acid and chenodeoxycholic acid both of which are secreted in the bile and affect the solubility of cholesterol. This gene is unique among the cytochrome P450 genes in that it is intronless. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1exogenous drug catabolic process (GO:0042738)9.87755380
2epoxygenase P450 pathway (GO:0019373)8.25550203
3omega-hydroxylase P450 pathway (GO:0097267)7.99591729
4L-phenylalanine catabolic process (GO:0006559)7.60832309
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.60832309
6L-phenylalanine metabolic process (GO:0006558)7.28554005
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.28554005
8aromatic amino acid family catabolic process (GO:0009074)6.93964426
9oxidative demethylation (GO:0070989)6.38911427
10indole-containing compound catabolic process (GO:0042436)6.35372891
11indolalkylamine catabolic process (GO:0046218)6.35372891
12tryptophan catabolic process (GO:0006569)6.35372891
13drug metabolic process (GO:0017144)6.33876097
14triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.22576672
15kynurenine metabolic process (GO:0070189)6.21765235
16* bile acid biosynthetic process (GO:0006699)6.01511537
17tryptophan metabolic process (GO:0006568)5.96357442
18glyoxylate metabolic process (GO:0046487)5.92375276
19alpha-linolenic acid metabolic process (GO:0036109)5.77440894
20urea cycle (GO:0000050)5.73490008
21urea metabolic process (GO:0019627)5.73490008
22phenylpropanoid metabolic process (GO:0009698)5.73477385
23negative regulation of fibrinolysis (GO:0051918)5.56545673
24high-density lipoprotein particle remodeling (GO:0034375)5.49837066
25sulfur amino acid catabolic process (GO:0000098)5.47637376
26complement activation, alternative pathway (GO:0006957)5.44059153
27cysteine metabolic process (GO:0006534)5.40670240
28regulation of protein activation cascade (GO:2000257)5.40193048
29regulation of fibrinolysis (GO:0051917)5.40177499
30peptidyl-glutamic acid carboxylation (GO:0017187)5.35080850
31protein carboxylation (GO:0018214)5.35080850
32regulation of plasminogen activation (GO:0010755)5.28573806
33nitrogen cycle metabolic process (GO:0071941)5.27595438
34serine family amino acid catabolic process (GO:0009071)5.16528690
35fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.11843923
36regulation of complement activation (GO:0030449)5.08606257
37* bile acid metabolic process (GO:0008206)5.05158470
38aromatic amino acid family metabolic process (GO:0009072)5.04092875
39S-adenosylmethionine metabolic process (GO:0046500)4.97743851
40alkaloid metabolic process (GO:0009820)4.93557603
41regulation of triglyceride catabolic process (GO:0010896)4.91600094
42ethanol metabolic process (GO:0006067)4.88969765
43homocysteine metabolic process (GO:0050667)4.88726921
44negative regulation of blood coagulation (GO:0030195)4.81891486
45negative regulation of hemostasis (GO:1900047)4.81891486
46tyrosine metabolic process (GO:0006570)4.81794751
47reverse cholesterol transport (GO:0043691)4.79232929
48regulation of cholesterol esterification (GO:0010872)4.79113871
49plasma lipoprotein particle remodeling (GO:0034369)4.70941546
50protein-lipid complex remodeling (GO:0034368)4.70941546
51macromolecular complex remodeling (GO:0034367)4.70941546
52alpha-amino acid catabolic process (GO:1901606)4.68974439
53amino-acid betaine metabolic process (GO:0006577)4.68738342
54lysine metabolic process (GO:0006553)4.64583828
55lysine catabolic process (GO:0006554)4.64583828
56triglyceride homeostasis (GO:0070328)4.60973673
57acylglycerol homeostasis (GO:0055090)4.60973673
58coenzyme catabolic process (GO:0009109)4.59508351
59glycine metabolic process (GO:0006544)4.50359432
60phospholipid efflux (GO:0033700)4.50114360
61cellular ketone body metabolic process (GO:0046950)4.49453379
62indolalkylamine metabolic process (GO:0006586)4.49444703
63acute-phase response (GO:0006953)4.47638242
64bile acid and bile salt transport (GO:0015721)4.44278572
65negative regulation of sterol transport (GO:0032372)4.44027935
66negative regulation of cholesterol transport (GO:0032375)4.44027935
67imidazole-containing compound metabolic process (GO:0052803)4.40513668
68amine catabolic process (GO:0009310)4.40232321
69cellular biogenic amine catabolic process (GO:0042402)4.40232321
70negative regulation of coagulation (GO:0050819)4.38442196
71negative regulation of wound healing (GO:0061045)4.34788082
72cellular amino acid catabolic process (GO:0009063)4.32630346
73plasma lipoprotein particle clearance (GO:0034381)4.30865607
74negative regulation of protein activation cascade (GO:2000258)4.29478670
75glutamate metabolic process (GO:0006536)4.27890247
76serine family amino acid metabolic process (GO:0009069)4.24043665
77regulation of humoral immune response (GO:0002920)4.21416363
78ethanol oxidation (GO:0006069)4.19930214
79cellular glucuronidation (GO:0052695)4.18103214
80benzene-containing compound metabolic process (GO:0042537)4.14621772
81cholesterol efflux (GO:0033344)4.14230467
82cellular modified amino acid catabolic process (GO:0042219)4.12023617
83dicarboxylic acid biosynthetic process (GO:0043650)4.10030333
84fat-soluble vitamin biosynthetic process (GO:0042362)4.08108854
85hormone catabolic process (GO:0042447)4.07550395
86arginine metabolic process (GO:0006525)4.07239033
87serine family amino acid biosynthetic process (GO:0009070)4.04731193
88positive regulation of hemostasis (GO:1900048)4.03045288
89positive regulation of blood coagulation (GO:0030194)4.03045288
90aldehyde catabolic process (GO:0046185)4.01436708
91fibrinolysis (GO:0042730)4.00367617
92intestinal cholesterol absorption (GO:0030299)3.98971540
93flavonoid metabolic process (GO:0009812)3.98044190
94cytolysis (GO:0019835)3.96569499
95heme transport (GO:0015886)3.96557384
96plasma lipoprotein particle assembly (GO:0034377)3.92954634
97low-density lipoprotein particle remodeling (GO:0034374)3.90193553
98ketone body metabolic process (GO:1902224)3.89121369
99cofactor catabolic process (GO:0051187)3.87586830
100blood coagulation, intrinsic pathway (GO:0007597)3.85243109
101complement activation, classical pathway (GO:0006958)3.84846702
102steroid catabolic process (GO:0006706)3.82692704
103acetyl-CoA metabolic process (GO:0006084)3.80762011
104organic acid catabolic process (GO:0016054)3.78806751
105carboxylic acid catabolic process (GO:0046395)3.78806751
106positive regulation of lipoprotein lipase activity (GO:0051006)3.78025781
107positive regulation of triglyceride lipase activity (GO:0061365)3.78025781
108complement activation (GO:0006956)3.77857399
109regulation of bile acid biosynthetic process (GO:0070857)3.73991098
110protein activation cascade (GO:0072376)3.73323700
111opsonization (GO:0008228)3.73161585
112phospholipid homeostasis (GO:0055091)3.72064714
113positive regulation of lipid catabolic process (GO:0050996)3.71695707
114negative regulation of lipase activity (GO:0060192)3.71581631
115positive regulation of coagulation (GO:0050820)3.71302985
116cholesterol homeostasis (GO:0042632)3.71297908
117uronic acid metabolic process (GO:0006063)3.71027355
118glucuronate metabolic process (GO:0019585)3.71027355
119very-low-density lipoprotein particle assembly (GO:0034379)3.67249599
120NAD biosynthetic process (GO:0009435)3.65171703
121sterol homeostasis (GO:0055092)3.64982178
122regulation of cholesterol homeostasis (GO:2000188)3.64877578
123short-chain fatty acid metabolic process (GO:0046459)3.63490873
124drug catabolic process (GO:0042737)3.62989185
125disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.62002042
126killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.62002042
127negative regulation of complement activation (GO:0045916)3.61907584
128* xenobiotic metabolic process (GO:0006805)3.61593245
129polyketide metabolic process (GO:0030638)3.61251264
130doxorubicin metabolic process (GO:0044598)3.61251264
131daunorubicin metabolic process (GO:0044597)3.61251264
132nicotinamide nucleotide biosynthetic process (GO:0019359)3.60885774
133pyridine nucleotide biosynthetic process (GO:0019363)3.60885774
134plasma lipoprotein particle organization (GO:0071827)3.56961503
135response to mercury ion (GO:0046689)3.56356384
136regulation of lipoprotein particle clearance (GO:0010984)3.52069911

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.41412073
2PPARA_22158963_ChIP-Seq_LIVER_Mouse7.25340856
3EGR1_23403033_ChIP-Seq_LIVER_Mouse7.10411346
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.51044473
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.36648231
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.03259436
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.82140086
8* NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.99394278
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.92165332
10TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.07428508
11ESR1_17901129_ChIP-ChIP_LIVER_Mouse12.0254419
12TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.99584891
13* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.93804564
14FOXA2_19822575_ChIP-Seq_HepG2_Human1.59914760
15HTT_18923047_ChIP-ChIP_STHdh_Human1.56343374
16CLOCK_20551151_ChIP-Seq_293T_Human1.53609678
17GATA1_22025678_ChIP-Seq_K562_Human1.45218959
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.43148005
19* HNF4A_19822575_ChIP-Seq_HepG2_Human1.39203324
20THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.26961226
21IRF1_19129219_ChIP-ChIP_H3396_Human1.24719124
22RXRA_24833708_ChIP-Seq_LIVER_Mouse1.21739330
23STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.20184256
24STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.17102167
25NFE2_27457419_Chip-Seq_LIVER_Mouse1.04952532
26ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01409918
27IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.00297968
28HNFA_21074721_ChIP-Seq_CACO-2_Human0.98962606
29ESR1_15608294_ChIP-ChIP_MCF-7_Human0.98532549
30CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.98292336
31ER_23166858_ChIP-Seq_MCF-7_Human0.96698262
32PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.96224532
33PHF8_20622853_ChIP-Seq_HELA_Human0.95430765
34MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.93321856
35SOX2_27498859_Chip-Seq_STOMACH_Mouse0.91832832
36PIAS1_25552417_ChIP-Seq_VCAP_Human0.91621125
37EZH2_27294783_Chip-Seq_NPCs_Mouse0.90084080
38IGF1R_20145208_ChIP-Seq_DFB_Human0.89801917
39ETV2_25802403_ChIP-Seq_MESCs_Mouse0.87992475
40PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.86798911
41ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.86793836
42TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.85438111
43GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.85129634
44GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.84687914
45POU3F2_20337985_ChIP-ChIP_501MEL_Human0.83760615
46NFYA_21822215_ChIP-Seq_K562_Human0.82996061
47RARG_19884340_ChIP-ChIP_MEFs_Mouse0.82607025
48ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.82258986
49IRF8_22096565_ChIP-ChIP_GC-B_Human0.81376379
50TRIM28_21343339_ChIP-Seq_HEK293_Human0.81307380
51SOX2_21211035_ChIP-Seq_LN229_Human0.81029401
52AUTS2_25519132_ChIP-Seq_293T-REX_Human0.81027032
53PCGF2_27294783_Chip-Seq_NPCs_Mouse0.80900511
54GATA6_21074721_ChIP-Seq_CACO-2_Human0.80864452
55SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.78815052
56GBX2_23144817_ChIP-Seq_PC3_Human0.78243270
57GATA4_25053715_ChIP-Seq_YYC3_Human0.77602819
58SUZ12_27294783_Chip-Seq_NPCs_Mouse0.76975855
59ZNF263_19887448_ChIP-Seq_K562_Human0.76875502
60TP53_18474530_ChIP-ChIP_U2OS_Human0.76827205
61CBX2_22325352_ChIP-Seq_293T-Rex_Human0.75988724
62KAP1_22055183_ChIP-Seq_ESCs_Mouse0.75151807
63KLF5_20875108_ChIP-Seq_MESCs_Mouse0.74900132
64RARA_24833708_ChIP-Seq_LIVER_Mouse0.74183864
65CRX_20693478_ChIP-Seq_RETINA_Mouse0.73568604
66BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.73056211
67ETV1_20927104_ChIP-Seq_GIST48_Human0.72599746
68EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.72115105
69* SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.72064866
70Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.71372401
71* RAC3_21632823_ChIP-Seq_H3396_Human0.70327050
72IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.68924184
73CBP_20019798_ChIP-Seq_JUKART_Human0.68924184
74FOXA1_27270436_Chip-Seq_PROSTATE_Human0.68900229
75FOXA1_25329375_ChIP-Seq_VCAP_Human0.68900229
76FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.68637991
77* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.68047940
78* MYC_19829295_ChIP-Seq_ESCs_Human0.67802794
79CDX2_22108803_ChIP-Seq_LS180_Human0.66991715
80CTBP1_25329375_ChIP-Seq_LNCAP_Human0.66684659
81AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.66169424
82ESR2_21235772_ChIP-Seq_MCF-7_Human0.65839296
83NRF2_20460467_ChIP-Seq_MEFs_Mouse0.65730254
84NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.65730254
85SALL4_18804426_ChIP-ChIP_XEN_Mouse0.64917296
86RARB_24833708_ChIP-Seq_LIVER_Mouse0.64646782
87NANOG_19829295_ChIP-Seq_ESCs_Human0.64456837
88SOX2_19829295_ChIP-Seq_ESCs_Human0.64456837
89ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.64440011
90OCT4_21477851_ChIP-Seq_ESCs_Mouse0.64078342
91PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.63592000
92FOXA1_21572438_ChIP-Seq_LNCaP_Human0.63336525
93NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.63242653
94RAD21_21589869_ChIP-Seq_MESCs_Mouse0.63172756
95SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.62560004
96RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.61979588
97NFYB_21822215_ChIP-Seq_K562_Human0.61976735
98TCF4_22108803_ChIP-Seq_LS180_Human0.60782153
99NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.60730934
100RBPJ_21746931_ChIP-Seq_IB4_Human0.60728320
101ERA_21632823_ChIP-Seq_H3396_Human0.60683266
102AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.60675955
103OCT4_18555785_Chip-Seq_ESCs_Mouse0.60395911
104EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.59827087
105BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.59482385
106CEBPB_22108803_ChIP-Seq_LS180_Human0.56585022
107EGR1_19032775_ChIP-ChIP_M12_Human0.56229227
108STAT3_1855785_ChIP-Seq_MESCs_Mouse0.54672518
109LXR_22292898_ChIP-Seq_THP-1_Human0.53898862
110AR_20517297_ChIP-Seq_VCAP_Human0.52491871
111MYC_19915707_ChIP-ChIP_AK7_Human0.52314312
112FOXA1_25552417_ChIP-Seq_VCAP_Human0.52230474
113PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.51655375
114FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.51561514
115FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.51155037
116ESET_19884257_ChIP-Seq_ESCs_Mouse0.48573761
117FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.47312743
118CBP_21632823_ChIP-Seq_H3396_Human0.47174862
119TAF15_26573619_Chip-Seq_HEK293_Human0.46801854
120PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.46770786
121P53_21459846_ChIP-Seq_SAOS-2_Human0.46405842
122PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.46132457
123NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.45569745
124STAT1_17558387_ChIP-Seq_HELA_Human0.44991425
125CDX2_20551321_ChIP-Seq_CACO-2_Human0.44248948
126PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.43933475
127ESR1_21235772_ChIP-Seq_MCF-7_Human0.43406124
128GATA1_19941827_ChIP-Seq_MEL_Mouse0.43002219
129FOXO3_23340844_ChIP-Seq_DLD1_Human0.42914953
130SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.42346310
131E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.41814589
132ESR1_20079471_ChIP-ChIP_T-47D_Human0.40670844
133FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.40229201
134* TAF2_19829295_ChIP-Seq_ESCs_Human0.39810244
135GATA1_19941826_ChIP-Seq_K562_Human0.39734946
136CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.39299352
137ERG_21242973_ChIP-ChIP_JURKAT_Human0.39064185
138STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.39010723
139BCAT_22108803_ChIP-Seq_LS180_Human0.38655661
140PPAR_26484153_Chip-Seq_NCI-H1993_Human0.38387920
141GATA2_19941826_ChIP-Seq_K562_Human0.38375344
142SPI1_26923725_Chip-Seq_HPCs_Mouse0.36722469
143GATA6_25053715_ChIP-Seq_YYC3_Human0.36713625
144* MYC_27129775_Chip-Seq_CORNEA_Mouse0.36365336
145LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.35516627
146SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.34980696
147ERG_20517297_ChIP-Seq_VCAP_Human0.34806899
148NCOR_22424771_ChIP-Seq_293T_Human0.33962149
149CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.33868893
150FOXH1_21741376_ChIP-Seq_EPCs_Human0.33752570
151SOX3_22085726_ChIP-Seq_MUSCLE_Mouse0.32790277

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.48789814
2MP0005360_urolithiasis7.59649616
3* MP0005085_abnormal_gallbladder_physiolo6.38071477
4* MP0005365_abnormal_bile_salt6.11726994
5MP0008875_abnormal_xenobiotic_pharmacok5.04748043
6MP0003806_abnormal_nucleotide_metabolis4.35407565
7MP0010329_abnormal_lipoprotein_level3.63711744
8* MP0003252_abnormal_bile_duct3.63464638
9MP0009840_abnormal_foam_cell3.30045792
10MP0005083_abnormal_biliary_tract3.07325174
11MP0003195_calcinosis2.82293013
12MP0005332_abnormal_amino_acid2.80487020
13* MP0001666_abnormal_nutrient_absorption2.41651040
14MP0003191_abnormal_cellular_cholesterol2.32087929
15* MP0000609_abnormal_liver_physiology2.17331985
16MP0004019_abnormal_vitamin_homeostasis2.12951415
17* MP0002118_abnormal_lipid_homeostasis2.12530513
18MP0002138_abnormal_hepatobiliary_system2.05699193
19MP0005319_abnormal_enzyme/_coenzyme1.87321402
20MP0001764_abnormal_homeostasis1.72178728
21MP0009697_abnormal_copulation1.60216141
22MP0005584_abnormal_enzyme/coenzyme_acti1.59529115
23* MP0003868_abnormal_feces_composition1.55591610
24MP0005451_abnormal_body_composition1.53524737
25MP0003011_delayed_dark_adaptation1.44983003
26MP0003186_abnormal_redox_activity1.28571405
27MP0003656_abnormal_erythrocyte_physiolo1.26884594
28MP0009643_abnormal_urine_homeostasis1.22309454
29MP0000598_abnormal_liver_morphology1.19866192
30MP0003705_abnormal_hypodermis_morpholog1.19782878
31MP0005647_abnormal_sex_gland1.19580851
32MP0009764_decreased_sensitivity_to1.05506831
33MP0000604_amyloidosis1.04322873
34MP0009763_increased_sensitivity_to1.00764778
35MP0002254_reproductive_system_inflammat0.97953336
36MP0010368_abnormal_lymphatic_system0.97333169
37MP0005636_abnormal_mineral_homeostasis0.91165698
38MP0008469_abnormal_protein_level0.89955131
39MP0005187_abnormal_penis_morphology0.86680979
40* MP0009642_abnormal_blood_homeostasis0.86474277
41MP0005408_hypopigmentation0.84655182
42MP0006036_abnormal_mitochondrial_physio0.84205162
43MP0005376_homeostasis/metabolism_phenot0.82439941
44MP0002078_abnormal_glucose_homeostasis0.78678291
45MP0002876_abnormal_thyroid_physiology0.78270630
46MP0005084_abnormal_gallbladder_morpholo0.77998864
47MP0009765_abnormal_xenobiotic_induced0.76606153
48MP0005670_abnormal_white_adipose0.75931703
49MP0002282_abnormal_trachea_morphology0.75710725
50MP0003879_abnormal_hair_cell0.73778075
51MP0005220_abnormal_exocrine_pancreas0.73725759
52MP0004130_abnormal_muscle_cell0.71745064
53MP0002971_abnormal_brown_adipose0.70891487
54MP0005535_abnormal_body_temperature0.70031753
55MP0005334_abnormal_fat_pad0.69800772
56MP0001915_intracranial_hemorrhage0.69444856
57MP0005266_abnormal_metabolism0.67749247
58MP0003690_abnormal_glial_cell0.67092457
59MP0009053_abnormal_anal_canal0.63396635
60MP0003329_amyloid_beta_deposits0.62840236
61MP0000639_abnormal_adrenal_gland0.62129109
62MP0006035_abnormal_mitochondrial_morpho0.61871385
63MP0004381_abnormal_hair_follicle0.61846219
64MP0001756_abnormal_urination0.59214322
65MP0001661_extended_life_span0.58197580
66MP0005448_abnormal_energy_balance0.54601410
67MP0002822_catalepsy0.51300548
68MP0002249_abnormal_larynx_morphology0.49040261
69MP0005464_abnormal_platelet_physiology0.48515660
70MP0002928_abnormal_bile_duct0.48207833
71MP0005395_other_phenotype0.46902382
72MP0003638_abnormal_response/metabolism_0.45454093
73MP0003718_maternal_effect0.45199114
74MP0008874_decreased_physiological_sensi0.45148929
75MP0003724_increased_susceptibility_to0.44194528
76MP0008873_increased_physiological_sensi0.43781042
77MP0002136_abnormal_kidney_physiology0.43429011
78MP0001986_abnormal_taste_sensitivity0.42917206
79MP0004142_abnormal_muscle_tone0.42857217
80MP0005166_decreased_susceptibility_to0.42165216
81MP0002837_dystrophic_cardiac_calcinosis0.41603568
82MP0003075_altered_response_to0.41110332
83MP0009785_altered_susceptibility_to0.40818694
84MP0003953_abnormal_hormone_level0.40212569
85MP0009384_cardiac_valve_regurgitation0.40198576
86MP0003436_decreased_susceptibility_to0.40043291
87MP0004782_abnormal_surfactant_physiolog0.39607355
88MP0005248_abnormal_Harderian_gland0.39383650
89MP0000579_abnormal_nail_morphology0.39079146
90MP0002796_impaired_skin_barrier0.39071440
91MP0005666_abnormal_adipose_tissue0.37121813
92MP0009672_abnormal_birth_weight0.36854315
93MP0006292_abnormal_olfactory_placode0.36001908
94MP0000230_abnormal_systemic_arterial0.35148444
95MP0005023_abnormal_wound_healing0.34804675
96MP0008872_abnormal_physiological_respon0.34180924
97MP0006082_CNS_inflammation0.32724075
98MP0004883_abnormal_blood_vessel0.32405003
99MP0010386_abnormal_urinary_bladder0.32393712
100MP0009115_abnormal_fat_cell0.31981164
101MP0001243_abnormal_dermal_layer0.31679737
102MP0001853_heart_inflammation0.31579061
103MP0000249_abnormal_blood_vessel0.31469715
104MP0002970_abnormal_white_adipose0.30580636
105MP0002168_other_aberrant_phenotype0.29721995
106MP0003959_abnormal_lean_body0.29721618
107MP0001845_abnormal_inflammatory_respons0.27533204
108MP0001881_abnormal_mammary_gland0.27022693
109MP0000467_abnormal_esophagus_morphology0.26344075
110MP0005646_abnormal_pituitary_gland0.25663321
111MP0002060_abnormal_skin_morphology0.25509591
112MP0005551_abnormal_eye_electrophysiolog0.25295588
113MP0005164_abnormal_response_to0.25283236
114MP0002132_abnormal_respiratory_system0.25240279
115MP0004043_abnormal_pH_regulation0.24993355
116MP0002090_abnormal_vision0.24726403
117MP0000566_synostosis0.21749428
118MP0005197_abnormal_uvea_morphology0.20614910
119MP0005058_abnormal_lysosome_morphology0.19514400
120MP0001944_abnormal_pancreas_morphology0.18699073
121MP0001440_abnormal_grooming_behavior0.17329079
122MP0002332_abnormal_exercise_endurance0.16514889

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)7.54081483
2Abnormality of aromatic amino acid family metabolism (HP:0004338)7.39333121
3Deep venous thrombosis (HP:0002625)7.32304356
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.74188589
5Prolonged partial thromboplastin time (HP:0003645)6.56197736
6Hypobetalipoproteinemia (HP:0003563)6.35872355
7Xanthomatosis (HP:0000991)6.32424667
8Complement deficiency (HP:0004431)5.58702746
9Hyperlipoproteinemia (HP:0010980)5.53165269
10Hypolipoproteinemia (HP:0010981)4.77343215
11Joint hemorrhage (HP:0005261)4.75257216
12Hyperammonemia (HP:0001987)4.62810971
13Epidermoid cyst (HP:0200040)4.60569807
14Hyperglycinemia (HP:0002154)4.48280705
15Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.35827330
16Abnormality of methionine metabolism (HP:0010901)4.34006444
17Abnormality of the common coagulation pathway (HP:0010990)4.32379489
18Abnormality of sulfur amino acid metabolism (HP:0004339)4.30301876
19Ketosis (HP:0001946)4.26282172
20Fat malabsorption (HP:0002630)4.21739582
21Hypoalphalipoproteinemia (HP:0003233)4.20663820
22Abnormality of aspartate family amino acid metabolism (HP:0010899)4.14678913
23Abnormality of complement system (HP:0005339)4.07942089
24Abnormality of glutamine family amino acid metabolism (HP:0010902)4.05615661
25Hyperglycinuria (HP:0003108)3.90526065
26Abnormality of glycine metabolism (HP:0010895)3.89466140
27Abnormality of serine family amino acid metabolism (HP:0010894)3.89466140
28Abnormality of pyrimidine metabolism (HP:0004353)3.86523154
29Hypoglycemic coma (HP:0001325)3.81167269
30Abnormality of the intrinsic pathway (HP:0010989)3.77107964
31Conjugated hyperbilirubinemia (HP:0002908)3.68005635
32Nephritis (HP:0000123)3.57948702
33Hypercholesterolemia (HP:0003124)3.50515238
34Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.48672748
35Abnormality of fatty-acid metabolism (HP:0004359)3.41091040
36Hyperbilirubinemia (HP:0002904)3.33375602
37Steatorrhea (HP:0002570)3.23448036
38Abnormality of serum amino acid levels (HP:0003112)3.09354049
39Delayed CNS myelination (HP:0002188)3.08106147
40Abnormality of nucleobase metabolism (HP:0010932)3.05754791
41Hypochromic microcytic anemia (HP:0004840)3.03499810
42Hepatocellular carcinoma (HP:0001402)3.02213866
43Ketoacidosis (HP:0001993)2.97069842
44Myocardial infarction (HP:0001658)2.95900342
45Reduced antithrombin III activity (HP:0001976)2.86097465
46Spontaneous abortion (HP:0005268)2.85173098
47Skin nodule (HP:0200036)2.84652456
48Systemic lupus erythematosus (HP:0002725)2.84119881
49Osteomalacia (HP:0002749)2.83884829
50Metabolic acidosis (HP:0001942)2.77450408
51Abnormality of purine metabolism (HP:0004352)2.65370609
52Lethargy (HP:0001254)2.60751536
53Abnormality of dicarboxylic acid metabolism (HP:0010995)2.60124270
54Dicarboxylic aciduria (HP:0003215)2.60124270
55Fair hair (HP:0002286)2.59646349
56Recurrent gram-negative bacterial infections (HP:0005420)2.57591998
57Acanthocytosis (HP:0001927)2.53625613
58Abnormal gallbladder morphology (HP:0012437)2.50556634
59Gout (HP:0001997)2.50104898
60Spastic diplegia (HP:0001264)2.49615995
61Vascular calcification (HP:0004934)2.49472388
62Arthropathy (HP:0003040)2.45316305
63Neonatal onset (HP:0003623)2.44232158
64Cholelithiasis (HP:0001081)2.43959628
65Abnormal gallbladder physiology (HP:0012438)2.43860248
66Cholecystitis (HP:0001082)2.43860248
67Mitral stenosis (HP:0001718)2.42803842
68Cerebral edema (HP:0002181)2.42266638
69Hypoglycemic seizures (HP:0002173)2.40361803
70Purpura (HP:0000979)2.38043699
71Irritability (HP:0000737)2.35735926
72Hyperphosphaturia (HP:0003109)2.34909170
73Pulmonary embolism (HP:0002204)2.33258045
74Glycosuria (HP:0003076)2.29273328
75Abnormality of urine glucose concentration (HP:0011016)2.29273328
76Malnutrition (HP:0004395)2.25677543
77Amyloidosis (HP:0011034)2.25543594
78Sensorimotor neuropathy (HP:0007141)2.24361913
79Glomerulonephritis (HP:0000099)2.22446952
80Cardiovascular calcification (HP:0011915)2.21096859
81Brushfield spots (HP:0001088)2.19045579
82Neonatal hypoglycemia (HP:0001998)2.17680691
83Pancreatitis (HP:0001733)2.16642764
84Bile duct proliferation (HP:0001408)2.15166817
85Abnormal biliary tract physiology (HP:0012439)2.15166817
86Enlarged kidneys (HP:0000105)2.13423651
87Esophageal varix (HP:0002040)2.13144277
88Gingival bleeding (HP:0000225)2.10443504
89Menorrhagia (HP:0000132)2.07918425
90Vomiting (HP:0002013)2.06566920
91Abnormality of the gallbladder (HP:0005264)2.05987323
92Late onset (HP:0003584)2.05234041
93Opisthotonus (HP:0002179)2.03072610
94Thrombophlebitis (HP:0004418)2.01484626
95Hemorrhage of the eye (HP:0011885)2.00535340
96Generalized aminoaciduria (HP:0002909)1.99839862
97Rickets (HP:0002748)1.97114863
98Poikilocytosis (HP:0004447)1.94866826
99Hyperinsulinemic hypoglycemia (HP:0000825)1.94384228
100Abnormal cartilage morphology (HP:0002763)1.90702256
101Renal cortical cysts (HP:0000803)1.89063528
102Abnormality of iron homeostasis (HP:0011031)1.86687931
103Elevated hepatic transaminases (HP:0002910)1.85329158
104Abnormal urine phosphate concentration (HP:0012599)1.84238039
105Abnormal enzyme/coenzyme activity (HP:0012379)1.84230864
106Bifid scrotum (HP:0000048)1.83455738
107Abnormality of transition element cation homeostasis (HP:0011030)1.82906988
108Elevated alkaline phosphatase (HP:0003155)1.82735557
109Status epilepticus (HP:0002133)1.81111530
110Hypophosphatemic rickets (HP:0004912)1.80453235
111Generalized hypopigmentation of hair (HP:0011358)1.79973942
112Gangrene (HP:0100758)1.78815553
113Abnormality of the Achilles tendon (HP:0005109)1.78653320
114Joint swelling (HP:0001386)1.76997165
115Increased serum ferritin (HP:0003281)1.76355665
116Abnormality of proline metabolism (HP:0010907)1.76058106
117Hydroxyprolinuria (HP:0003080)1.76058106
118Alkalosis (HP:0001948)1.73543935
119Abnormality of vitamin metabolism (HP:0100508)1.73125599
120Hyperglycemia (HP:0003074)1.71549920
121Cerebral palsy (HP:0100021)1.70854432
122Increased mean platelet volume (HP:0011877)1.70313356
123Abnormality of alkaline phosphatase activity (HP:0004379)1.68596410
124Acute hepatic failure (HP:0006554)1.66470425
125Atrioventricular block (HP:0001678)1.64931985
126Abnormal platelet function (HP:0011869)1.57215740
127Impaired platelet aggregation (HP:0003540)1.57215740
128Retinal atrophy (HP:0001105)1.56515382

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.19488424
2FGFR44.64202073
3ERN14.47939856
4SIK14.32798762
5ERBB43.16464694
6TAOK33.12120512
7INSRR2.95411659
8PIK3CA2.45948592
9WNK32.43541689
10MAP2K42.39267567
11NTRK32.26682936
12PKN22.16474619
13MST1R2.03835310
14MAPK111.98481447
15FLT31.90036493
16MAP4K21.78773910
17PIK3CG1.78474167
18TYK21.67805088
19TRIB31.66793528
20ADRBK21.65916468
21LATS11.64097927
22MAPKAPK31.53146292
23DAPK21.52931191
24ABL21.52724333
25PTK61.44770807
26CAMKK21.41649473
27NEK91.40078066
28TNK21.39023621
29NLK1.38898294
30FGFR21.38543703
31FRK1.31023782
32KDR1.29168945
33WNK41.26304357
34MAP3K121.25998778
35JAK21.24203559
36MAP3K71.23283814
37PRKACA1.19740643
38PRKG11.18093346
39PINK11.17830103
40MAP3K101.14137966
41ERBB21.10880347
42PRKAA21.10783057
43TBK11.07790630
44MAPK151.07772361
45GRK61.06611500
46FER1.05272671
47JAK11.02040202
48MAP2K31.01641837
49MAPK40.99738128
50ACVR1B0.95653418
51MAP3K140.94441599
52PRKCZ0.94129288
53MYLK0.90936425
54TLK10.90741837
55CSNK1D0.89801514
56MUSK0.85487092
57EPHB10.84384396
58MAPK120.83475455
59MET0.83327097
60STK38L0.82593675
61CDK60.82106958
62PRKCE0.81568875
63TIE10.80433250
64STK160.77525650
65CAMK2G0.77441468
66PRKACG0.75657929
67PDK20.75377329
68MAP3K30.75294226
69EPHA30.74767306
70MAP3K110.74271700
71CAMKK10.74153438
72PRKCB0.73820653
73IRAK30.72922598
74DYRK1B0.72047142
75BMPR1B0.70726517
76SGK10.68310259
77GSK3A0.67445643
78BCR0.67247971
79CSK0.66928655
80PRKAA10.65841438
81RPS6KA30.65489039
82MAP2K60.64413686
83DYRK20.64162752
84SGK30.63893795
85CASK0.63373540
86CSNK1A10.62977298
87CAMK1D0.60599415
88MAPK70.60491055
89CSF1R0.57719857
90FGFR30.56254544
91PRKACB0.55722197
92RIPK10.55605586
93TGFBR20.55270344
94PDPK10.54859519
95PKN10.54601791
96CSNK1G10.54580694
97PTK20.54570054
98PRKCQ0.53536805
99IKBKE0.53144763
100CSNK1E0.52799557
101STK380.49670430
102CHUK0.47161861
103GRK10.46390094
104SGK20.45073788
105CSNK2A10.45055443
106IKBKB0.44528894
107ADRBK10.44193935
108IGF1R0.43909350
109TNIK0.43888333
110ICK0.43789931
111OXSR10.43538433
112PRKCG0.42311301
113CDK40.41673872
114MAP2K10.41165934
115MAP3K130.40959624
116MAP3K50.40767025
117MAP3K20.40706773
118RET0.40380522
119TXK0.39952252
120EPHA40.38936859
121BRSK20.37489685
122ZAP700.36993489
123SRC0.36597417
124EGFR0.36410820
125MTOR0.35806802
126CAMK40.35111825
127CSNK1G20.34517189
128CSNK1G30.33962550
129PBK0.33805820
130TAOK20.33440448
131MAP3K60.33390194
132PDK10.32854688
133MAP3K10.32169580
134SGK2230.31352400
135SGK4940.31352400
136LATS20.30020582
137PRKCA0.25991252
138IRAK20.25666177
139CSNK1A1L0.24843180
140BMX0.23136891
141IRAK10.23116280
142PAK30.22160246
143ABL10.22067286
144MAP2K20.20205279
145AKT30.19343706

Predicted pathways (KEGG)

RankGene SetZ-score
1* Primary bile acid biosynthesis_Homo sapiens_hsa001204.60058081
2Nitrogen metabolism_Homo sapiens_hsa009103.49291977
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.39893489
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.26954949
5Arginine biosynthesis_Homo sapiens_hsa002203.08425115
6Complement and coagulation cascades_Homo sapiens_hsa046102.76322413
7Tryptophan metabolism_Homo sapiens_hsa003802.73685412
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.72136300
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.66476959
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.59102294
11Fatty acid degradation_Homo sapiens_hsa000712.55007443
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.42091583
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.18904761
14Butanoate metabolism_Homo sapiens_hsa006502.18571675
15Peroxisome_Homo sapiens_hsa041462.15414923
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.05656048
17Propanoate metabolism_Homo sapiens_hsa006401.94565855
18Histidine metabolism_Homo sapiens_hsa003401.90620322
19Chemical carcinogenesis_Homo sapiens_hsa052041.88002393
20Steroid hormone biosynthesis_Homo sapiens_hsa001401.87644552
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.85706418
22Fatty acid metabolism_Homo sapiens_hsa012121.85200922
23* PPAR signaling pathway_Homo sapiens_hsa033201.82985386
24Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.74827560
25beta-Alanine metabolism_Homo sapiens_hsa004101.73036271
26Drug metabolism - other enzymes_Homo sapiens_hsa009831.72095909
27Staphylococcus aureus infection_Homo sapiens_hsa051501.69143183
28Retinol metabolism_Homo sapiens_hsa008301.68296068
29Caffeine metabolism_Homo sapiens_hsa002321.67311641
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.67286229
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.61725368
32Selenocompound metabolism_Homo sapiens_hsa004501.57443007
33Phenylalanine metabolism_Homo sapiens_hsa003601.56176775
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.52740344
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.50112348
36Bile secretion_Homo sapiens_hsa049761.48788120
37Tyrosine metabolism_Homo sapiens_hsa003501.46298613
38Fatty acid elongation_Homo sapiens_hsa000621.42321374
39Pyruvate metabolism_Homo sapiens_hsa006201.38528259
40Sulfur metabolism_Homo sapiens_hsa009201.36333077
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.35984589
42Starch and sucrose metabolism_Homo sapiens_hsa005001.26025288
43Folate biosynthesis_Homo sapiens_hsa007901.25534909
44Steroid biosynthesis_Homo sapiens_hsa001001.21430178
45Biosynthesis of amino acids_Homo sapiens_hsa012301.20496357
46ABC transporters_Homo sapiens_hsa020101.17701544
47Fat digestion and absorption_Homo sapiens_hsa049751.14175480
48Carbon metabolism_Homo sapiens_hsa012001.13185360
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.12511467
50Vitamin B6 metabolism_Homo sapiens_hsa007501.04298718
51Maturity onset diabetes of the young_Homo sapiens_hsa049501.00556620
52Sulfur relay system_Homo sapiens_hsa041220.99123242
53Cyanoamino acid metabolism_Homo sapiens_hsa004600.97134667
54Arginine and proline metabolism_Homo sapiens_hsa003300.95302357
55Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.93394655
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.87719119
57Vitamin digestion and absorption_Homo sapiens_hsa049770.83196224
58Lysine degradation_Homo sapiens_hsa003100.82422897
59Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.80226887
60One carbon pool by folate_Homo sapiens_hsa006700.76876849
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70323837
62Glycerolipid metabolism_Homo sapiens_hsa005610.65712525
63Glutathione metabolism_Homo sapiens_hsa004800.64557521
64Pentose phosphate pathway_Homo sapiens_hsa000300.55910876
65Fatty acid biosynthesis_Homo sapiens_hsa000610.55612728
66Prion diseases_Homo sapiens_hsa050200.46618908
67Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.46570108
68* Metabolic pathways_Homo sapiens_hsa011000.45769917
69Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.36462182
70Galactose metabolism_Homo sapiens_hsa000520.26030365
71alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25448000
72Fructose and mannose metabolism_Homo sapiens_hsa000510.22932111
73Insulin resistance_Homo sapiens_hsa049310.22836300
74Adipocytokine signaling pathway_Homo sapiens_hsa049200.22423248
75Pertussis_Homo sapiens_hsa051330.21302600
76Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.19490839
77Linoleic acid metabolism_Homo sapiens_hsa005910.18798999
78Glycerophospholipid metabolism_Homo sapiens_hsa005640.16494625
79Glucagon signaling pathway_Homo sapiens_hsa049220.10777785
80Serotonergic synapse_Homo sapiens_hsa047260.04824070
81AMPK signaling pathway_Homo sapiens_hsa041520.01677775
82Type II diabetes mellitus_Homo sapiens_hsa04930-0.2388983
83Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2373680
84Bladder cancer_Homo sapiens_hsa05219-0.2360909
85Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2346631
86Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2256872
87Vascular smooth muscle contraction_Homo sapiens_hsa04270-0.2245066
88N-Glycan biosynthesis_Homo sapiens_hsa00510-0.2239085
89Circadian rhythm_Homo sapiens_hsa04710-0.2137653
90Amoebiasis_Homo sapiens_hsa05146-0.2136668
91Renin-angiotensin system_Homo sapiens_hsa04614-0.2073243
92Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1938455
93Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1928526
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1884259
95Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563-0.1769521
96Hepatitis C_Homo sapiens_hsa05160-0.1762727
97Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1603679
98Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1600901
99Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1550642
100Other glycan degradation_Homo sapiens_hsa00511-0.1405156
101African trypanosomiasis_Homo sapiens_hsa05143-0.1330680
102Regulation of autophagy_Homo sapiens_hsa04140-0.1266847
103Sphingolipid metabolism_Homo sapiens_hsa00600-0.1241272
104Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1194101
105Insulin signaling pathway_Homo sapiens_hsa04910-0.1019346
106Ether lipid metabolism_Homo sapiens_hsa00565-0.0950866
107Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0892075
108Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0853841
109Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0738752
110Mineral absorption_Homo sapiens_hsa04978-0.0474935
111Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0449387

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