CYR61

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The secreted protein encoded by this gene is growth factor-inducible and promotes the adhesion of endothelial cells. The encoded protein interacts with several integrins and with heparan sulfate proteoglycan. This protein also plays a role in cell proliferation, differentiation, angiogenesis, apoptosis, and extracellular matrix formation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chondrocyte proliferation (GO:0035988)5.99140296
2wound healing, spreading of epidermal cells (GO:0035313)5.48607654
3positive regulation of endothelial cell apoptotic process (GO:2000353)5.16165207
4collagen fibril organization (GO:0030199)5.11336533
5sequestering of extracellular ligand from receptor (GO:0035581)4.96217472
6cell adhesion mediated by integrin (GO:0033627)4.71930611
7endodermal cell differentiation (GO:0035987)4.60613034
8skin morphogenesis (GO:0043589)4.32276885
9protein heterotrimerization (GO:0070208)4.19219841
10mesenchymal-epithelial cell signaling (GO:0060638)4.15316539
11bone trabecula formation (GO:0060346)4.06844158
12hemidesmosome assembly (GO:0031581)4.03853641
13endothelial cell chemotaxis (GO:0035767)3.89051867
14regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.88168870
15* wound healing, spreading of cells (GO:0044319)3.84242111
16negative regulation of fatty acid transport (GO:2000192)3.79297355
17regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.78936124
18axon extension involved in axon guidance (GO:0048846)3.77027231
19neuron projection extension involved in neuron projection guidance (GO:1902284)3.77027231
20regulation of tight junction assembly (GO:2000810)3.72438914
21negative regulation of chondrocyte differentiation (GO:0032331)3.71546957
22epithelial cell-cell adhesion (GO:0090136)3.69050963
23protein localization to cell surface (GO:0034394)3.66793561
24mesodermal cell differentiation (GO:0048333)3.64395914
25type B pancreatic cell proliferation (GO:0044342)3.43944759
26collagen metabolic process (GO:0032963)3.43721680
27vascular endothelial growth factor signaling pathway (GO:0038084)3.43280129
28endothelial cell morphogenesis (GO:0001886)3.42879454
29metanephric mesenchyme development (GO:0072075)3.40585470
30craniofacial suture morphogenesis (GO:0097094)3.39937366
31lymphangiogenesis (GO:0001946)3.39246999
32positive regulation of epithelial to mesenchymal transition (GO:0010718)3.38780162
33endocardial cushion development (GO:0003197)3.35482154
34hippo signaling (GO:0035329)3.33841644
35basement membrane organization (GO:0071711)3.31717694
36cell migration involved in sprouting angiogenesis (GO:0002042)3.30386829
37branching involved in salivary gland morphogenesis (GO:0060445)3.29836124
38collagen catabolic process (GO:0030574)3.28979901
39kidney mesenchyme development (GO:0072074)3.28167425
40regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.27691466
41cell-substrate junction assembly (GO:0007044)3.26064318
42retina vasculature morphogenesis in camera-type eye (GO:0061299)3.25797987
43virion attachment to host cell (GO:0019062)3.23611729
44adhesion of symbiont to host cell (GO:0044650)3.23611729
45cellular response to vitamin D (GO:0071305)3.21905185
46cellular response to vitamin (GO:0071295)3.21475194
47extracellular matrix disassembly (GO:0022617)3.20628578
48maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.19268074
49apoptotic cell clearance (GO:0043277)3.18494236
50multicellular organismal macromolecule metabolic process (GO:0044259)3.17513083
51notochord development (GO:0030903)3.17213373
52dermatan sulfate biosynthetic process (GO:0030208)3.17037968
53focal adhesion assembly (GO:0048041)3.15266890
54cell-substrate adherens junction assembly (GO:0007045)3.15266890
55regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.13432630
56substrate adhesion-dependent cell spreading (GO:0034446)3.12768735
57cell proliferation involved in kidney development (GO:0072111)3.11606069
58extracellular negative regulation of signal transduction (GO:1900116)3.10107505
59extracellular regulation of signal transduction (GO:1900115)3.10107505
60negative regulation of cartilage development (GO:0061037)3.09358261
61pericardium development (GO:0060039)3.09143727
62neural crest cell development (GO:0014032)3.09064697
63protein retention in ER lumen (GO:0006621)3.05470725
64actin filament depolymerization (GO:0030042)3.03790177
65Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.02877034
66plasma membrane repair (GO:0001778)3.01991087
67desmosome organization (GO:0002934)3.01188551
68glomerular basement membrane development (GO:0032836)3.01054821
69multicellular organismal metabolic process (GO:0044236)2.99369343
70multicellular organismal catabolic process (GO:0044243)2.98906143
71positive regulation of blood vessel endothelial cell migration (GO:0043536)2.98503859
72paraxial mesoderm development (GO:0048339)2.96258437
73positive regulation of macrophage activation (GO:0043032)2.95731510
74negative regulation of smooth muscle cell migration (GO:0014912)2.95423855
75positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.94879906
76renal filtration (GO:0097205)2.94735022
77cranial suture morphogenesis (GO:0060363)2.93475175
78vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.93133259
79cell proliferation involved in metanephros development (GO:0072203)2.92908362
80stress fiber assembly (GO:0043149)2.92049879
81cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.91439988
82venous blood vessel morphogenesis (GO:0048845)2.88650245
83regulation of establishment of planar polarity (GO:0090175)2.87985967
84cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.87575915
85regulation of plasminogen activation (GO:0010755)2.86541250
86extracellular matrix assembly (GO:0085029)2.86237593
87cell migration involved in heart development (GO:0060973)2.86091446
88fibroblast migration (GO:0010761)2.85468188
89adhesion of symbiont to host (GO:0044406)2.85063233
90heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.84843882
91dermatan sulfate metabolic process (GO:0030205)2.84667419
92planar cell polarity pathway involved in neural tube closure (GO:0090179)2.84430056
93muscle cell migration (GO:0014812)2.83692617
94cellular response to interferon-alpha (GO:0035457)2.83254421
95extracellular fibril organization (GO:0043206)2.82813478
96cochlea morphogenesis (GO:0090103)2.82613542
97regulation of hippo signaling (GO:0035330)2.82343654
98blood vessel endothelial cell migration (GO:0043534)2.81746925
99regulation of integrin-mediated signaling pathway (GO:2001044)2.81695575
100positive regulation of astrocyte differentiation (GO:0048711)2.79791146
101* extracellular matrix organization (GO:0030198)2.79123808
102adherens junction assembly (GO:0034333)2.79006817
103negative regulation of catenin import into nucleus (GO:0035414)2.78737857
104* extracellular structure organization (GO:0043062)2.77966519
105embryonic cranial skeleton morphogenesis (GO:0048701)2.77340197
106Golgi transport vesicle coating (GO:0048200)2.77201963
107COPI coating of Golgi vesicle (GO:0048205)2.77201963
108smooth muscle tissue development (GO:0048745)2.76616029
109peptidyl-proline hydroxylation (GO:0019511)2.76262003
110polarized epithelial cell differentiation (GO:0030859)2.76192079
111fibril organization (GO:0097435)2.73112954
112G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.71685867
113axis elongation (GO:0003401)2.71316677
114regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.70784144
115positive regulation of extracellular matrix organization (GO:1903055)2.70583522
116regulation of chondrocyte differentiation (GO:0032330)2.70449930
117outer ear morphogenesis (GO:0042473)2.69789226
118chondrocyte development (GO:0002063)2.69716832
119positive regulation of collagen biosynthetic process (GO:0032967)2.67526179
120wound healing (GO:0042060)2.67279970
121* positive regulation of cartilage development (GO:0061036)2.66647053
122dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.65666675
123protein targeting to plasma membrane (GO:0072661)2.64226732
124regulation of SMAD protein import into nucleus (GO:0060390)2.64096829
125epithelial to mesenchymal transition (GO:0001837)2.64040126
126positive regulation of p38MAPK cascade (GO:1900745)2.63709093
127negative regulation of BMP signaling pathway (GO:0030514)2.63547520
128* regulation of cartilage development (GO:0061035)2.63518282
129sprouting angiogenesis (GO:0002040)2.63240890
130negative regulation of anoikis (GO:2000811)2.63131948
131blood vessel maturation (GO:0001955)2.62541854
132trabecula formation (GO:0060343)2.61960818
133positive regulation of stem cell differentiation (GO:2000738)2.61735807
134regulation of gastrulation (GO:0010470)2.61716343
135substrate-dependent cell migration (GO:0006929)2.60589937
136cell-substrate adhesion (GO:0031589)2.58811982
137negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.56537727

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.73069809
2TRIM28_21343339_ChIP-Seq_HEK293_Human6.87775277
3RARG_19884340_ChIP-ChIP_MEFs_Mouse5.03790771
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.68294630
5CLOCK_20551151_ChIP-Seq_293T_Human3.26879796
6PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.20267192
7SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.15528869
8* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.74490263
9* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.65200972
10* CJUN_26792858_Chip-Seq_BT549_Human2.61536195
11TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.59115658
12HIF1A_21447827_ChIP-Seq_MCF-7_Human2.46401698
13ESR1_21235772_ChIP-Seq_MCF-7_Human2.45758257
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.40698859
15WT1_19549856_ChIP-ChIP_CCG9911_Human2.37738049
16TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.28307084
17* SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.27422572
18* SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.27422572
19* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.19524255
20EP300_21415370_ChIP-Seq_HL-1_Mouse2.13364633
21BRD4_25478319_ChIP-Seq_HGPS_Human2.12722679
22ESR2_21235772_ChIP-Seq_MCF-7_Human2.09819312
23* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.09311034
24ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.94255284
25PPAR_26484153_Chip-Seq_NCI-H1993_Human1.94037996
26* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.91774008
27* NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.90790000
28NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.86794943
29NRF2_20460467_ChIP-Seq_MEFs_Mouse1.86794943
30* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.77239575
31WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.76696970
32CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.73688046
33* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.69236472
34TP53_16413492_ChIP-PET_HCT116_Human1.68559010
35* ELK3_25401928_ChIP-Seq_HUVEC_Human1.67441933
36* TP53_20018659_ChIP-ChIP_R1E_Mouse1.65753004
37JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.65744550
38RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.63236338
39TP53_18474530_ChIP-ChIP_U2OS_Human1.62997158
40SOX2_20726797_ChIP-Seq_SW620_Human1.59249977
41THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.56778696
42* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.54799301
43* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.51726709
44UBF1/2_26484160_Chip-Seq_HMECs_Human1.50034565
45ZNF263_19887448_ChIP-Seq_K562_Human1.47835916
46ZNF217_24962896_ChIP-Seq_MCF-7_Human1.47279681
47* ATF3_27146783_Chip-Seq_COLON_Human1.45641522
48JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.45559086
49SMC1_22415368_ChIP-Seq_MEFs_Mouse1.45262292
50* NFIB_24661679_ChIP-Seq_LUNG_Mouse1.43296500
51SMAD_19615063_ChIP-ChIP_OVARY_Human1.43135754
52STAT6_21828071_ChIP-Seq_BEAS2B_Human1.42714348
53GATA2_21666600_ChIP-Seq_HMVEC_Human1.37741617
54FOXM1_23109430_ChIP-Seq_U2OS_Human1.37138370
55FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.37052090
56* FOXO3_23340844_ChIP-Seq_DLD1_Human1.35062884
57ELK1_22589737_ChIP-Seq_MCF10A_Human1.29721089
58EED_16625203_ChIP-ChIP_MESCs_Mouse1.29148490
59MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.28577935
60RBPJ_22232070_ChIP-Seq_NCS_Mouse1.28572347
61ESR1_15608294_ChIP-ChIP_MCF-7_Human1.28391745
62HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.27943634
63* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.26678109
64* TP53_23651856_ChIP-Seq_MEFs_Mouse1.24716335
65TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.23897037
66TP53_22127205_ChIP-Seq_IMR90_Human1.23612655
67ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.22020684
68EZH2_18974828_ChIP-Seq_MESCs_Mouse1.21021751
69RNF2_18974828_ChIP-Seq_MESCs_Mouse1.21021751
70SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.20890973
71P63_26484246_Chip-Seq_KERATINOCYTES_Human1.20586396
72SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.18842108
73* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.17873635
74HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.17823333
75P300_27058665_Chip-Seq_ZR-75-30cells_Human1.17798328
76TCF3_18692474_ChIP-Seq_MEFs_Mouse1.16615679
77* KDM2B_26808549_Chip-Seq_K562_Human1.15776116
78ZFP281_27345836_Chip-Seq_ESCs_Mouse1.13964016
79SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.13125935
80* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.13083855
81CDX2_19796622_ChIP-Seq_MESCs_Mouse1.11820529
82* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.11593914
83* SMC3_22415368_ChIP-Seq_MEFs_Mouse1.11337369
84DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.11116467
85LXR_22292898_ChIP-Seq_THP-1_Human1.11003850
86* RACK7_27058665_Chip-Seq_MCF-7_Human1.09381475
87ESR1_20079471_ChIP-ChIP_T-47D_Human1.07983203
88* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.06626562
89* TBX20_22080862_ChIP-Seq_HEART_Mouse1.06563136
90* TBX20_22328084_ChIP-Seq_HEART_Mouse1.06563136
91DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.05886586
92* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.04678958
93POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.04309235
94TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.04003091
95KLF5_25053715_ChIP-Seq_YYC3_Human1.03116219
96CDX2_20551321_ChIP-Seq_CACO-2_Human1.02730606
97TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01459566
98ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.00426840
99CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.00266959
100NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.99362231
101* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.98031366
102PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.97276219
103TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97273557
104ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.95206143
105EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.95103338
106* ISL1_27105846_Chip-Seq_CPCs_Mouse0.94741515
107AR_21909140_ChIP-Seq_LNCAP_Human0.92628400
108RUNX1_27514584_Chip-Seq_MCF-7_Human0.91440509
109ZFP281_18757296_ChIP-ChIP_E14_Mouse0.88781855
110* SA1_22415368_ChIP-Seq_MEFs_Mouse0.88669073
111TET1_21490601_ChIP-Seq_MESCs_Mouse0.88460756
112PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.87856808
113TCF4_18268006_ChIP-ChIP_LS174T_Human0.86761883
114* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.86418930
115RXR_22108803_ChIP-Seq_LS180_Human0.86177125
116KDM2B_26808549_Chip-Seq_SUP-B15_Human0.86070149
117RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.85935874
118* TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.84610656
119* TP63_23658742_ChIP-Seq_EP156T_Human0.84503392
120KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.84487393
121KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.84487393
122KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.84487393

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.16464195
2MP0005275_abnormal_skin_tensile4.27490168
3MP0005503_abnormal_tendon_morphology3.97727386
4MP0003279_aneurysm3.87906582
5MP0003705_abnormal_hypodermis_morpholog3.86251445
6MP0004272_abnormal_basement_membrane3.37050262
7MP0001958_emphysema3.14851401
8MP0009384_cardiac_valve_regurgitation3.05768321
9MP0010030_abnormal_orbit_morphology2.58531775
10MP0005623_abnormal_meninges_morphology2.55936275
11MP0003566_abnormal_cell_adhesion2.49540792
12MP0010368_abnormal_lymphatic_system2.33197277
13MP0005023_abnormal_wound_healing2.24681707
14MP0010352_gastrointestinal_tract_polyps2.20305591
15MP0002295_abnormal_pulmonary_circulatio2.15401991
16MP0006054_spinal_hemorrhage2.15295046
17MP0005508_abnormal_skeleton_morphology2.03158542
18MP0003091_abnormal_cell_migration2.01337412
19MP0002060_abnormal_skin_morphology1.97358189
20MP0003941_abnormal_skin_development1.89382797
21MP0009250_abnormal_appendicular_skeleto1.88461010
22MP0000751_myopathy1.75921316
23MP0003385_abnormal_body_wall1.75343968
24MP0005257_abnormal_intraocular_pressure1.74144305
25MP0001542_abnormal_bone_strength1.62673926
26MP0000767_abnormal_smooth_muscle1.60760478
27MP0009053_abnormal_anal_canal1.54960324
28MP0001879_abnormal_lymphatic_vessel1.52053357
29MP0001243_abnormal_dermal_layer1.42804084
30MP0000762_abnormal_tongue_morphology1.42580008
31MP0002282_abnormal_trachea_morphology1.41458087
32MP0001299_abnormal_eye_distance/1.41297145
33MP0003942_abnormal_urinary_system1.41144158
34MP0000733_abnormal_muscle_development1.37918048
35MP0002896_abnormal_bone_mineralization1.37668842
36MP0002877_abnormal_melanocyte_morpholog1.36037274
37MP0000537_abnormal_urethra_morphology1.32701147
38MP0002108_abnormal_muscle_morphology1.29829588
39MP0000750_abnormal_muscle_regeneration1.28823538
40MP0000163_abnormal_cartilage_morphology1.23707417
41MP0004858_abnormal_nervous_system1.21729606
42MP0003755_abnormal_palate_morphology1.19780541
43MP0002254_reproductive_system_inflammat1.19426129
44MP0005390_skeleton_phenotype1.19292477
45MP0005197_abnormal_uvea_morphology1.18140447
46MP0000428_abnormal_craniofacial_morphol1.17462241
47MP0003115_abnormal_respiratory_system1.17303520
48MP0000013_abnormal_adipose_tissue1.15015313
49MP0000534_abnormal_ureter_morphology1.14861536
50MP0003828_pulmonary_edema1.12604586
51MP0009780_abnormal_chondrocyte_physiolo1.07669184
52MP0002932_abnormal_joint_morphology1.06027956
53MP0000049_abnormal_middle_ear1.04855608
54MP0005595_abnormal_vascular_smooth1.04436879
55MP0001849_ear_inflammation1.02344730
56MP0002115_abnormal_skeleton_extremities1.01038657
57MP0003283_abnormal_digestive_organ1.00193774
58MP0002089_abnormal_postnatal_growth/wei0.99127706
59MP0003937_abnormal_limbs/digits/tail_de0.97254770
60MP0001348_abnormal_lacrimal_gland0.96035473
61MP0002168_other_aberrant_phenotype0.95892405
62MP0002113_abnormal_skeleton_development0.95020649
63MP0004134_abnormal_chest_morphology0.94500734
64* MP0001614_abnormal_blood_vessel0.94048301
65MP0000749_muscle_degeneration0.93270618
66MP0001346_abnormal_lacrimal_gland0.92725873
67* MP0002128_abnormal_blood_circulation0.91177556
68MP0002233_abnormal_nose_morphology0.90746842
69MP0000432_abnormal_head_morphology0.90143244
70MP0005164_abnormal_response_to0.89796438
71MP0000759_abnormal_skeletal_muscle0.89504225
72MP0004883_abnormal_blood_vessel0.89315666
73MP0006138_congestive_heart_failure0.88690810
74MP0000467_abnormal_esophagus_morphology0.88323872
75* MP0002925_abnormal_cardiovascular_devel0.87660497
76MP0003935_abnormal_craniofacial_develop0.87620982
77MP0000858_altered_metastatic_potential0.87176065
78MP0005076_abnormal_cell_differentiation0.86473023
79MP0003045_fibrosis0.86110013
80MP0000462_abnormal_digestive_system0.85755222
81MP0002111_abnormal_tail_morphology0.85205315
82MP0005388_respiratory_system_phenotype0.85018923
83MP0002133_abnormal_respiratory_system0.85018923
84MP0009840_abnormal_foam_cell0.84170929
85MP0008004_abnormal_stomach_pH0.82597907
86MP0002177_abnormal_outer_ear0.81025490
87MP0002116_abnormal_craniofacial_bone0.80876213
88MP0003950_abnormal_plasma_membrane0.80728604
89MP0003300_gastrointestinal_ulcer0.80706449
90MP0002092_abnormal_eye_morphology0.79338650
91MP0003453_abnormal_keratinocyte_physiol0.78449758
92MP0001175_abnormal_lung_morphology0.78272459
93MP0002109_abnormal_limb_morphology0.76895476
94MP0001915_intracranial_hemorrhage0.75988014
95MP0005367_renal/urinary_system_phenotyp0.75933015
96MP0000516_abnormal_urinary_system0.75933015
97MP0001533_abnormal_skeleton_physiology0.75093931
98MP0002933_joint_inflammation0.74265228
99MP0004084_abnormal_cardiac_muscle0.72940145
100MP0009278_abnormal_bone_marrow0.72132434
101MP0002998_abnormal_bone_remodeling0.70207194
102MP0008007_abnormal_cellular_replicative0.70101008
103MP0000003_abnormal_adipose_tissue0.69644436
104MP0002249_abnormal_larynx_morphology0.69617097
105MP0002697_abnormal_eye_size0.68986649
106MP0005084_abnormal_gallbladder_morpholo0.68333615
107MP0001177_atelectasis0.68258150
108MP0003795_abnormal_bone_structure0.68120616
109MP0002114_abnormal_axial_skeleton0.67829284
110MP0000566_synostosis0.67155706
111MP0004233_abnormal_muscle_weight0.66926923
112MP0005193_abnormal_anterior_eye0.65848939
113MP0002234_abnormal_pharynx_morphology0.65797614
114MP0001340_abnormal_eyelid_morphology0.65107334
115MP0004087_abnormal_muscle_fiber0.64227697
116MP0005171_absent_coat_pigmentation0.63846886
117MP0001286_abnormal_eye_development0.60857218
118MP0005501_abnormal_skin_physiology0.60066652
119MP0010386_abnormal_urinary_bladder0.59792294
120MP0005621_abnormal_cell_physiology0.58628720

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)7.35438096
2Protrusio acetabuli (HP:0003179)7.13223433
3Atrophic scars (HP:0001075)5.04201668
4Shallow orbits (HP:0000586)4.78644939
5Aortic dissection (HP:0002647)4.39632121
6Aortic aneurysm (HP:0004942)4.25884056
7Peritonitis (HP:0002586)4.07816603
8Soft skin (HP:0000977)3.93164323
9Fragile skin (HP:0001030)3.91608483
10Abnormality of dentin (HP:0010299)3.76694101
11Broad metatarsal (HP:0001783)3.74837226
12Dilatation of the ascending aorta (HP:0005111)3.74452838
13Ankle contracture (HP:0006466)3.69483198
14Cerebral aneurysm (HP:0004944)3.63401053
15Bladder diverticulum (HP:0000015)3.41282785
16Wormian bones (HP:0002645)3.38502367
17Spinal rigidity (HP:0003306)3.28160998
18Cervical subluxation (HP:0003308)3.22726511
19Neonatal short-limb short stature (HP:0008921)3.18795895
20Wrist flexion contracture (HP:0001239)3.16828143
21Vascular tortuosity (HP:0004948)3.16724372
22Short nail (HP:0001799)3.12024318
23Increased connective tissue (HP:0009025)2.95019068
24Vertebral compression fractures (HP:0002953)2.90200252
25Blue sclerae (HP:0000592)2.89641365
26Biconcave vertebral bodies (HP:0004586)2.83947744
27Spondylolisthesis (HP:0003302)2.75112652
28Aortic regurgitation (HP:0001659)2.69412253
29Follicular hyperkeratosis (HP:0007502)2.68689241
30Aplasia involving bones of the extremities (HP:0009825)2.64923542
31Aplasia involving bones of the upper limbs (HP:0009823)2.64923542
32Aplasia of the phalanges of the hand (HP:0009802)2.64923542
33Mitral valve prolapse (HP:0001634)2.64248362
34Mesomelia (HP:0003027)2.61731137
35Genu recurvatum (HP:0002816)2.61627133
36Arterial tortuosity (HP:0005116)2.58305331
37Right ventricular cardiomyopathy (HP:0011663)2.47356640
38Type 1 muscle fiber predominance (HP:0003803)2.41985432
39Bowel diverticulosis (HP:0005222)2.37213460
40Overgrowth (HP:0001548)2.33541315
41Hyperextensible skin (HP:0000974)2.33467992
42Osteolytic defects of the hand bones (HP:0009699)2.33357019
43Osteolytic defects of the phalanges of the hand (HP:0009771)2.33357019
44Aortic valve stenosis (HP:0001650)2.32654434
45Elbow flexion contracture (HP:0002987)2.31261925
46Aneurysm (HP:0002617)2.30109554
47Camptodactyly of toe (HP:0001836)2.25610085
48Slender build (HP:0001533)2.25308230
49Distal lower limb muscle weakness (HP:0009053)2.24760783
50Short hallux (HP:0010109)2.24013569
51Abnormality of the acetabulum (HP:0003170)2.22479596
52Coronal craniosynostosis (HP:0004440)2.22352824
53Infantile muscular hypotonia (HP:0008947)2.21377335
54Natal tooth (HP:0000695)2.19669532
55Short 4th metacarpal (HP:0010044)2.18994603
56Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.18994603
57Abnormal delivery (HP:0001787)2.18731525
58Milia (HP:0001056)2.16441324
59Broad face (HP:0000283)2.16132751
60Ectopia lentis (HP:0001083)2.15170270
61Wide anterior fontanel (HP:0000260)2.13032333
62Cardiovascular calcification (HP:0011915)2.12225490
63Mitral regurgitation (HP:0001653)2.11706289
64Deviation of the hallux (HP:0010051)2.09590828
65Disproportionate tall stature (HP:0001519)2.09208942
66Scapular winging (HP:0003691)2.09199287
67Ulnar bowing (HP:0003031)2.04452561
68Bronchomalacia (HP:0002780)2.03178705
69Aplasia/Hypoplasia of the hallux (HP:0008362)2.02779422
70Round ear (HP:0100830)2.02507192
71Hallux valgus (HP:0001822)2.01700615
72Radial bowing (HP:0002986)2.01458083
73Abnormality of the calcaneus (HP:0008364)2.00279207
74Joint laxity (HP:0001388)1.99222411
75Coxa vara (HP:0002812)1.98407085
76Bowing of the arm (HP:0006488)1.97821944
77Bowed forearm bones (HP:0003956)1.97821944
78Nonimmune hydrops fetalis (HP:0001790)1.97130660
79Bell-shaped thorax (HP:0001591)1.96950456
80Knee flexion contracture (HP:0006380)1.94133164
81Tibial bowing (HP:0002982)1.93999950
82Achilles tendon contracture (HP:0001771)1.93100374
83Thin bony cortex (HP:0002753)1.91972257
84Femoral bowing (HP:0002980)1.91848044
85Tarsal synostosis (HP:0008368)1.91846295
86Hypoventilation (HP:0002791)1.90811114
87Increased density of long bones (HP:0006392)1.90396773
88Generalized amyotrophy (HP:0003700)1.90053245
89Renal duplication (HP:0000075)1.89312180
90Mildly elevated creatine phosphokinase (HP:0008180)1.89285343
91Hyperacusis (HP:0010780)1.88639158
92Abnormality of the peritoneum (HP:0002585)1.87646041
93Mitral stenosis (HP:0001718)1.87548382
94Distal upper limb amyotrophy (HP:0007149)1.86616085
95Upper limb amyotrophy (HP:0009129)1.86616085
96Absent frontal sinuses (HP:0002688)1.86534557
97Delayed cranial suture closure (HP:0000270)1.85551114
98Fused cervical vertebrae (HP:0002949)1.85105111
99Difficulty climbing stairs (HP:0003551)1.82093084
100Broad long bones (HP:0005622)1.81881264
101Long toe (HP:0010511)1.81221018
102Entropion (HP:0000621)1.81191623
103Abnormality of the 2nd finger (HP:0004100)1.80991420
104Reduced subcutaneous adipose tissue (HP:0003758)1.80987605
105Abnormality of skeletal muscle fiber size (HP:0012084)1.80324245
106Fibular aplasia (HP:0002990)1.80187842
107Alopecia of scalp (HP:0002293)1.79891142
108Buphthalmos (HP:0000557)1.78362799
109Abnormality of the distal phalanges of the toes (HP:0010182)1.78289549
110Mild short stature (HP:0003502)1.78191576
111Inguinal hernia (HP:0000023)1.77774696
112Increased variability in muscle fiber diameter (HP:0003557)1.77561083
113Abnormal ossification of hand bones (HP:0005921)1.77095558
114Broad toe (HP:0001837)1.76391341
115Broad hallux (HP:0010055)1.76269470
116Distal lower limb amyotrophy (HP:0008944)1.76264846
117Limb-girdle muscle weakness (HP:0003325)1.76188468
118Selective tooth agenesis (HP:0001592)1.75532052
119Spinal cord lesions (HP:0100561)1.75494311
120Syringomyelia (HP:0003396)1.75494311
121Protruding ear (HP:0000411)1.75175896
122Decreased skull ossification (HP:0004331)1.74354945
123Broad ribs (HP:0000885)1.74260629
124Joint contractures involving the joints of the feet (HP:0100492)1.73068459
125Flexion contracture of toe (HP:0005830)1.73068459
126Abnormality of the distal phalanx of the thumb (HP:0009617)1.72471735
127Thin ribs (HP:0000883)1.72007442
128Joint stiffness (HP:0001387)1.71957558
129Morphological abnormality of the middle ear (HP:0008609)1.67867126
130Breech presentation (HP:0001623)1.67800591
131Abnormality of the phalanges of the hallux (HP:0010057)1.67675536
132Congenital glaucoma (HP:0001087)1.67118345

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA24.49301620
2TTN4.16249269
3DDR23.28239265
4LATS22.80929194
5TESK12.79032320
6LATS12.58789615
7EPHB22.54626047
8MAP3K32.51221691
9PAK22.35040837
10PDGFRA2.32872679
11NTRK12.27937495
12LIMK12.24169781
13TRIB32.22356468
14PTK22.03012784
15FER2.00363216
16MYLK1.94143030
17ICK1.92242156
18SIK11.86814791
19ERN11.85419769
20TRPM71.81408821
21PAK31.77083576
22EPHA31.75524068
23TGFBR21.74679418
24RPS6KA41.66692598
25PIM21.63775238
26PIK3CA1.60000132
27STK38L1.58117555
28AKT31.55269777
29PTK2B1.51590629
30DMPK1.50734871
31STK101.46802963
32KDR1.46598537
33BMX1.46248006
34MOS1.45544208
35ERBB31.43605468
36LRRK21.37468972
37PAK41.31951994
38MAPK151.28431352
39MET1.28396651
40STK381.28100043
41TAOK21.23037761
42ROCK11.21458467
43PTK61.18916534
44MAP2K11.17857701
45MAP2K21.17468795
46TIE11.17376739
47PKN21.16192630
48ZAK1.16152450
49FLT31.15409042
50RIPK11.11559512
51FGFR11.10015018
52PIK3CG1.09953851
53TGFBR11.09601897
54RPS6KB21.07004596
55PNCK1.06740663
56MAPKAPK31.06692989
57CDK121.02944595
58STK31.01408994
59BRSK21.00856682
60WEE11.00244979
61TESK20.99913348
62SMG10.97186671
63MAP3K60.94800958
64ILK0.87456511
65MAP2K30.84863799
66MELK0.84694588
67IRAK30.80324168
68PDGFRB0.80268073
69MTOR0.78886087
70NEK90.76581593
71BRSK10.75264103
72EPHB10.73422096
73MAP3K110.71828853
74PRKG20.71235912
75ROCK20.69171415
76MST40.69071742
77TAOK10.64870415
78INSR0.64274004
79PAK10.63349173
80FGFR20.62970329
81DAPK30.62132706
82PDK20.61841495
83NUAK10.61452526
84PRKD10.60940675
85FRK0.60793566
86NME20.60432992
87MAP3K80.58865506
88CDC42BPA0.58069167
89MAP3K70.57294520
90CDK60.55932931
91BUB10.55258945
92ARAF0.54079531
93MAPKAPK20.52613339
94PAK60.52603187
95MST1R0.51622122
96PLK20.50996982
97NEK20.49307396
98RPS6KL10.48059665
99RPS6KC10.48059665
100RAF10.47514526
101CDK90.44272010
102MAP3K120.43313691
103ABL20.40887104
104ERBB40.40814600
105CAMK2G0.35607552
106SRC0.35242761
107AURKA0.35083616
108RPS6KA60.34675337
109AURKB0.34610234
110ADRBK10.34018734
111TSSK60.33499767
112MAPKAPK50.32542508
113ERBB20.29761443
114GSK3A0.28850019
115CHUK0.28661645
116MAPK70.28479774
117MARK20.28167968
118CDK70.28019256
119MAPK10.26442781
120IGF1R0.26167339
121WNK10.25417750
122PRKCE0.25143155
123FGFR40.24743989
124EEF2K0.23235681
125CDK80.20489394
126LMTK20.20473692
127ABL10.19866874
128PRKD30.19251287
129BCR0.18857974
130PRKD20.18226944
131RPS6KA20.16924560
132PLK30.16777904

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.53538002
2Focal adhesion_Homo sapiens_hsa045103.29910377
3Adherens junction_Homo sapiens_hsa045202.63518638
4Proteoglycans in cancer_Homo sapiens_hsa052052.62946467
5Bladder cancer_Homo sapiens_hsa052192.62088381
6Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.60578435
7Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.49337066
8TGF-beta signaling pathway_Homo sapiens_hsa043502.48761351
9Hippo signaling pathway_Homo sapiens_hsa043902.47469970
10Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.44740695
11Small cell lung cancer_Homo sapiens_hsa052222.37318215
12AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.29792872
13Amoebiasis_Homo sapiens_hsa051462.26295140
14Dilated cardiomyopathy_Homo sapiens_hsa054142.24718685
15Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.22566718
16Basal cell carcinoma_Homo sapiens_hsa052172.15966505
17Malaria_Homo sapiens_hsa051442.05577915
18Protein digestion and absorption_Homo sapiens_hsa049742.00090049
19Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.87831428
20MicroRNAs in cancer_Homo sapiens_hsa052061.83557734
21p53 signaling pathway_Homo sapiens_hsa041151.83495719
22Leukocyte transendothelial migration_Homo sapiens_hsa046701.76278754
23Hedgehog signaling pathway_Homo sapiens_hsa043401.75742205
24PI3K-Akt signaling pathway_Homo sapiens_hsa041511.73740737
25Tight junction_Homo sapiens_hsa045301.67927664
26Regulation of actin cytoskeleton_Homo sapiens_hsa048101.60272117
27Melanoma_Homo sapiens_hsa052181.49260853
28Shigellosis_Homo sapiens_hsa051311.42775646
29Viral myocarditis_Homo sapiens_hsa054161.40359777
30Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.36762086
31Pathways in cancer_Homo sapiens_hsa052001.31802097
32Rap1 signaling pathway_Homo sapiens_hsa040151.30769146
33TNF signaling pathway_Homo sapiens_hsa046681.26858602
34Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.22734723
35Chronic myeloid leukemia_Homo sapiens_hsa052201.22467022
36HTLV-I infection_Homo sapiens_hsa051661.19609665
37Wnt signaling pathway_Homo sapiens_hsa043101.13862526
38Prostate cancer_Homo sapiens_hsa052151.08796543
39Toxoplasmosis_Homo sapiens_hsa051451.08602693
40Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.07750067
41Axon guidance_Homo sapiens_hsa043601.05528092
42Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.94123403
43Salmonella infection_Homo sapiens_hsa051320.91928465
44Other glycan degradation_Homo sapiens_hsa005110.88414321
45Apoptosis_Homo sapiens_hsa042100.87291864
46Platelet activation_Homo sapiens_hsa046110.78029056
47Chemical carcinogenesis_Homo sapiens_hsa052040.77376823
48Melanogenesis_Homo sapiens_hsa049160.76819640
49HIF-1 signaling pathway_Homo sapiens_hsa040660.76678687
50Pancreatic cancer_Homo sapiens_hsa052120.73607438
51Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.73349695
52Phagosome_Homo sapiens_hsa041450.71544908
53Sulfur relay system_Homo sapiens_hsa041220.71389010
54Notch signaling pathway_Homo sapiens_hsa043300.71068642
55Colorectal cancer_Homo sapiens_hsa052100.70067011
56Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.69732689
57Renal cell carcinoma_Homo sapiens_hsa052110.68729917
58Galactose metabolism_Homo sapiens_hsa000520.67613245
59Cocaine addiction_Homo sapiens_hsa050300.66778885
60Viral carcinogenesis_Homo sapiens_hsa052030.65744312
61Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.65107450
62Vibrio cholerae infection_Homo sapiens_hsa051100.64646475
63Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.64499916
64Gap junction_Homo sapiens_hsa045400.61899561
65Ras signaling pathway_Homo sapiens_hsa040140.61169532
66Hepatitis B_Homo sapiens_hsa051610.60303054
67Glioma_Homo sapiens_hsa052140.59835528
68Phospholipase D signaling pathway_Homo sapiens_hsa040720.59785541
69cGMP-PKG signaling pathway_Homo sapiens_hsa040220.59470179
70Glutathione metabolism_Homo sapiens_hsa004800.57405259
71Leishmaniasis_Homo sapiens_hsa051400.55159496
72MAPK signaling pathway_Homo sapiens_hsa040100.52328821
73Estrogen signaling pathway_Homo sapiens_hsa049150.52170928
74Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51455202
75Thyroid cancer_Homo sapiens_hsa052160.51336839
76Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50006581
77Folate biosynthesis_Homo sapiens_hsa007900.48306978
78Pertussis_Homo sapiens_hsa051330.47732051
79Central carbon metabolism in cancer_Homo sapiens_hsa052300.47220311
80Vascular smooth muscle contraction_Homo sapiens_hsa042700.46736944
81Complement and coagulation cascades_Homo sapiens_hsa046100.46385713
82Glycosaminoglycan degradation_Homo sapiens_hsa005310.45034025
83Endocytosis_Homo sapiens_hsa041440.43853156
84FoxO signaling pathway_Homo sapiens_hsa040680.43565173
85Pentose phosphate pathway_Homo sapiens_hsa000300.42595283
86GnRH signaling pathway_Homo sapiens_hsa049120.42560177
87Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.42538851
88Cell cycle_Homo sapiens_hsa041100.41710059
89AMPK signaling pathway_Homo sapiens_hsa041520.41476437
90Aldosterone synthesis and secretion_Homo sapiens_hsa049250.41293887
91Endometrial cancer_Homo sapiens_hsa052130.40469580
92Ovarian steroidogenesis_Homo sapiens_hsa049130.39575193
93Biosynthesis of amino acids_Homo sapiens_hsa012300.39353235
94Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.38575303
95Lysine degradation_Homo sapiens_hsa003100.37378004
96VEGF signaling pathway_Homo sapiens_hsa043700.36809299
97Thyroid hormone signaling pathway_Homo sapiens_hsa049190.36668028
98ErbB signaling pathway_Homo sapiens_hsa040120.36270037
99Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.34940226
100Rheumatoid arthritis_Homo sapiens_hsa053230.33895506
101Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.33480930
102Prion diseases_Homo sapiens_hsa050200.32812881
103Thyroid hormone synthesis_Homo sapiens_hsa049180.32798268
104Transcriptional misregulation in cancer_Homo sapiens_hsa052020.31611610
105Vitamin B6 metabolism_Homo sapiens_hsa007500.31342044
106Glucagon signaling pathway_Homo sapiens_hsa049220.30986238
107Selenocompound metabolism_Homo sapiens_hsa004500.30534866
108Sphingolipid metabolism_Homo sapiens_hsa006000.29798471
109Hematopoietic cell lineage_Homo sapiens_hsa046400.29598027
110cAMP signaling pathway_Homo sapiens_hsa040240.29048057
111Neurotrophin signaling pathway_Homo sapiens_hsa047220.29043064
112Osteoclast differentiation_Homo sapiens_hsa043800.28660169
113Arachidonic acid metabolism_Homo sapiens_hsa005900.28467616
114Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.28009393
115Caffeine metabolism_Homo sapiens_hsa002320.27846034
116N-Glycan biosynthesis_Homo sapiens_hsa005100.25206949
117Legionellosis_Homo sapiens_hsa051340.24553512
118Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.23434926
119Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.21894388
120Longevity regulating pathway - mammal_Homo sapiens_hsa042110.21751860

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