CYSLTR2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are important mediators of human bronchial asthma. Pharmacologic studies have determined that cysteinyl leukotrienes activate at least 2 receptors, the protein encoded by this gene and CYSLTR1. This encoded receptor is a member of the superfamily of G protein-coupled receptors. It seems to play a major role in endocrine and cardiovascular systems. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G8.19947292
2positive regulation of chemokine secretion (GO:0090197)7.55054523
3regulation of chemokine secretion (GO:0090196)6.50195458
4antigen processing and presentation of endogenous antigen (GO:0019883)6.15085166
5T cell migration (GO:0072678)6.12056493
6cellular response to interleukin-15 (GO:0071350)6.05573922
7negative thymic T cell selection (GO:0045060)5.65112439
8antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.60255213
9antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.60255213
10response to interleukin-15 (GO:0070672)5.54373070
11negative T cell selection (GO:0043383)5.52661258
12positive regulation of gamma-delta T cell activation (GO:0046645)5.42089590
13leukocyte aggregation (GO:0070486)5.26097098
14positive thymic T cell selection (GO:0045059)5.00964348
15positive regulation of T-helper 1 type immune response (GO:0002827)4.76487688
16positive regulation of macrophage activation (GO:0043032)4.76327866
17regulation of gamma-delta T cell differentiation (GO:0045586)4.64356078
18negative regulation of adaptive immune response based on somatic recombination of immune receptors b4.53557503
19mucosal-associated lymphoid tissue development (GO:0048537)4.48306500
20Peyers patch development (GO:0048541)4.48306500
21interferon-gamma production (GO:0032609)4.42420076
22cellular extravasation (GO:0045123)4.42155827
23regulation of gamma-delta T cell activation (GO:0046643)4.27925044
24positive regulation of alpha-beta T cell proliferation (GO:0046641)4.21775210
25regulation of interleukin-5 production (GO:0032674)4.21204780
26regulation of leukocyte mediated cytotoxicity (GO:0001910)4.19673728
27positive regulation of natural killer cell mediated immunity (GO:0002717)4.19211316
28positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.19211316
29positive regulation of leukocyte mediated cytotoxicity (GO:0001912)4.18300629
30NIK/NF-kappaB signaling (GO:0038061)4.17938547
31thymic T cell selection (GO:0045061)4.16155004
32regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.15513863
33regulation of natural killer cell mediated immunity (GO:0002715)4.15513863
34regulation of gonadotropin secretion (GO:0032276)4.10130365
35negative regulation of adaptive immune response (GO:0002820)4.09855668
36positive regulation of antigen processing and presentation (GO:0002579)4.03792555
37regulation of isotype switching to IgG isotypes (GO:0048302)4.03183145
38antigen processing and presentation via MHC class Ib (GO:0002475)4.02294774
39myeloid dendritic cell differentiation (GO:0043011)3.99018603
40positive T cell selection (GO:0043368)3.97484730
41negative regulation of cell killing (GO:0031342)3.95608830
42negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.95608830
43positive regulation of macrophage differentiation (GO:0045651)3.95014252
44regulation of T cell mediated cytotoxicity (GO:0001914)3.92971880
45microglial cell activation (GO:0001774)3.90994009
46regulation of dendritic cell antigen processing and presentation (GO:0002604)3.90989301
47myeloid dendritic cell activation (GO:0001773)3.90636091
48tolerance induction (GO:0002507)3.89541100
49positive regulation of T cell mediated cytotoxicity (GO:0001916)3.89176331
50hepatocyte apoptotic process (GO:0097284)3.87132418
51cellular response to type I interferon (GO:0071357)3.86728414
52type I interferon signaling pathway (GO:0060337)3.86728414
53response to type I interferon (GO:0034340)3.86334004
54sequestering of actin monomers (GO:0042989)3.86222494
55negative regulation of macrophage differentiation (GO:0045650)3.81958728
56regulation of alpha-beta T cell proliferation (GO:0046640)3.80633453
57regulation of T-helper 1 type immune response (GO:0002825)3.80370317
58lymphocyte migration (GO:0072676)3.79804630
59cellular response to follicle-stimulating hormone stimulus (GO:0071372)3.79311671
60regulation of activation of Janus kinase activity (GO:0010533)3.77842408
61regulation of T-helper 1 cell differentiation (GO:0045625)3.76771887
62hemoglobin metabolic process (GO:0020027)3.76754766
63regulation of cell killing (GO:0031341)3.76309940
64macrophage activation involved in immune response (GO:0002281)3.72802959
65detection of molecule of bacterial origin (GO:0032490)3.72237001
66T cell costimulation (GO:0031295)3.71035314
67positive regulation of cell killing (GO:0031343)3.70538510
68regulation of memory T cell differentiation (GO:0043380)3.70120325
69positive regulation of defense response to virus by host (GO:0002230)3.70033111
70lymphocyte costimulation (GO:0031294)3.67698875
71positive regulation of granulocyte chemotaxis (GO:0071624)3.67570627
72modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.67316594
73positive regulation by organism of defense response of other organism involved in symbiotic interact3.67316594
74modulation by symbiont of host immune response (GO:0052553)3.67316594
75positive regulation by symbiont of host defense response (GO:0052509)3.67316594
76modulation by symbiont of host defense response (GO:0052031)3.67316594
77modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.67316594
78neutrophil activation involved in immune response (GO:0002283)3.66248693
79DNA deamination (GO:0045006)3.65980244
80positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.63319885
81regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.61440933
82T cell selection (GO:0045058)3.60734776
83negative regulation of interferon-gamma production (GO:0032689)3.55247505
84positive regulation of T-helper cell differentiation (GO:0045624)3.51595662
85regulation of antigen processing and presentation (GO:0002577)3.46004951
86lymphocyte chemotaxis (GO:0048247)3.44223881
87daunorubicin metabolic process (GO:0044597)3.43824802
88polyketide metabolic process (GO:0030638)3.43824802
89doxorubicin metabolic process (GO:0044598)3.43824802
90regulation of response to interferon-gamma (GO:0060330)3.42484560
91T-helper cell differentiation (GO:0042093)3.39811790
92CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.39811790
93positive regulation of mitotic sister chromatid separation (GO:1901970)3.37863007
94positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.37863007
95positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.37863007
96positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.35929280
97interferon-gamma-mediated signaling pathway (GO:0060333)3.35347698
98regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.34991906
99positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.33745380
100regulation of RIG-I signaling pathway (GO:0039535)3.29747631
101positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.29330342
102positive regulation of Cdc42 GTPase activity (GO:0043089)3.25301028
103negative regulation of interleukin-10 production (GO:0032693)3.23331078
104positive regulation of neutrophil chemotaxis (GO:0090023)3.23066491
105positive regulation of neutrophil migration (GO:1902624)3.23066491
106regulation of regulatory T cell differentiation (GO:0045589)3.21402752
107macrophage activation (GO:0042116)3.20566220
108regulation of natural killer cell differentiation (GO:0032823)3.18735514
109lymph node development (GO:0048535)3.18677945
110regulation of B cell differentiation (GO:0045577)3.18472259
111JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.17737388
112positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.17503879
113neutrophil mediated immunity (GO:0002446)3.16953387
114leukocyte cell-cell adhesion (GO:0007159)3.14843638
115positive regulation of T cell differentiation (GO:0045582)3.14710207
116negative regulation of interleukin-12 production (GO:0032695)3.14009375
117natural killer cell activation (GO:0030101)3.13725804
118positive regulation of mast cell activation (GO:0033005)3.12490183
119regulation of mast cell activation (GO:0033003)3.12485692
120T cell receptor signaling pathway (GO:0050852)3.12405437
121positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.11512695
122cellular defense response (GO:0006968)3.11344531
123regulation of type I interferon-mediated signaling pathway (GO:0060338)3.10976153
124mature B cell differentiation involved in immune response (GO:0002313)3.10168689
125positive regulation of natural killer cell differentiation (GO:0032825)3.09822202
126regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.09242575
127dendritic cell differentiation (GO:0097028)3.08773942
128regulation of endothelial cell differentiation (GO:0045601)3.03990964
129regulation of B cell receptor signaling pathway (GO:0050855)3.03748599
130dendritic cell chemotaxis (GO:0002407)3.01161002
131positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.00083643
132T cell differentiation involved in immune response (GO:0002292)2.98280308
133alpha-beta T cell activation involved in immune response (GO:0002287)2.98280308
134negative regulation of T cell mediated immunity (GO:0002710)2.97424026
135detection of other organism (GO:0098543)2.95333049
136detection of external biotic stimulus (GO:0098581)2.94234922
137negative regulation of lymphocyte mediated immunity (GO:0002707)2.92855637
138neutrophil activation (GO:0042119)2.91699980
139regulation of macrophage differentiation (GO:0045649)2.88551381
140phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.87349886
141myeloid cell activation involved in immune response (GO:0002275)2.84394780
142regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.73421007
143positive regulation of tyrosine phosphorylation of Stat3 protein (GO:0042517)2.73313536
144cellular response to sterol (GO:0036315)2.73298933
145response to peptidoglycan (GO:0032494)2.72561996
146positive regulation of chemokine production (GO:0032722)2.72115170
147positive regulation of granulocyte differentiation (GO:0030854)2.72011131
148negative regulation of complement activation (GO:0045916)2.71382941
149myeloid leukocyte mediated immunity (GO:0002444)2.70880841
150regulation of mast cell activation involved in immune response (GO:0033006)2.70103650
151regulation of macrophage activation (GO:0043030)2.68036904
152detection of biotic stimulus (GO:0009595)2.68024033
153B cell receptor signaling pathway (GO:0050853)2.67896302
154establishment of protein localization to Golgi (GO:0072600)2.67798983
155response to host immune response (GO:0052572)2.67374274
156response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.67374274
157positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.66436885
158negative regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043124)2.65958804
159definitive hemopoiesis (GO:0060216)2.64741911
160dendritic cell migration (GO:0036336)2.64599683
161cellular response to ethanol (GO:0071361)2.63639361
162positive regulation of erythrocyte differentiation (GO:0045648)2.63450505
163negative regulation of B cell activation (GO:0050869)2.61115468
164positive regulation of mast cell activation involved in immune response (GO:0033008)2.61042744
165positive regulation of mast cell degranulation (GO:0043306)2.61042744
166regulation of mast cell degranulation (GO:0043304)2.60486929
167production of molecular mediator involved in inflammatory response (GO:0002532)2.56449174
168response to follicle-stimulating hormone (GO:0032354)2.56185045
169regulation of interferon-beta biosynthetic process (GO:0045357)2.56017444
170regulation of tolerance induction (GO:0002643)2.55361352
171protein targeting to Golgi (GO:0000042)2.53959424
172detection of bacterium (GO:0016045)2.53547750
173endocrine hormone secretion (GO:0060986)2.52595062
174histamine secretion (GO:0001821)2.52379713
175cell wall macromolecule catabolic process (GO:0016998)2.49354072
176regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.48673162
177amine catabolic process (GO:0009310)2.47789551

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.52577606
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.41148836
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.69123053
4* IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.74845567
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.74751722
6* STAT3_20064451_ChIP-Seq_CD4+T_Mouse4.07448154
7STAT4_19710469_ChIP-ChIP_TH1__Mouse4.05758834
8RUNX_20019798_ChIP-Seq_JUKART_Human3.87186171
9IRF8_21731497_ChIP-ChIP_J774_Mouse3.69172721
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.38301211
11RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.99844658
12FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.90360512
13SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.86246190
14SMAD_19615063_ChIP-ChIP_OVARY_Human2.80479193
15MYB_26560356_Chip-Seq_TH2_Human2.79665685
16FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.68034608
17IRF8_27001747_Chip-Seq_BMDM_Mouse2.57360509
18* SCL_19346495_ChIP-Seq_HPC-7_Human2.57192255
19BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.51298430
20SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.46212900
21NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.28881471
22MYB_26560356_Chip-Seq_TH1_Human2.27885365
23ELF1_17652178_ChIP-ChIP_JURKAT_Human2.27390311
24MAF_26560356_Chip-Seq_TH1_Human2.24473885
25RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.22164024
26BP1_19119308_ChIP-ChIP_Hs578T_Human2.20719636
27UTX_26944678_Chip-Seq_JUKART_Human2.17603102
28LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.08034644
29RUNX1_22412390_ChIP-Seq_EML_Mouse2.03153283
30CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.97625869
31MYB_21317192_ChIP-Seq_ERMYB_Mouse1.96713052
32NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.95381874
33POU3F2_20337985_ChIP-ChIP_501MEL_Human1.95295213
34SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.92328737
35RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.88148760
36FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.86433555
37GBX2_23144817_ChIP-Seq_PC3_Human1.79800450
38GATA3_27048872_Chip-Seq_THYMUS_Human1.78267782
39SPI1_23547873_ChIP-Seq_NB4_Human1.77986596
40ZNF274_21170338_ChIP-Seq_K562_Hela1.76187384
41VDR_21846776_ChIP-Seq_THP-1_Human1.74703347
42NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.74598927
43ZFP57_27257070_Chip-Seq_ESCs_Mouse1.73659796
44LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.73175631
45EGR1_19374776_ChIP-ChIP_THP-1_Human1.72757610
46VDR_24763502_ChIP-Seq_THP-1_Human1.72629831
47MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.69725332
48GATA1_22025678_ChIP-Seq_K562_Human1.68633716
49NOTCH1_21737748_ChIP-Seq_TLL_Human1.66204665
50GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.64656168
51MYC_22102868_ChIP-Seq_BL_Human1.64482178
52ER_23166858_ChIP-Seq_MCF-7_Human1.58050594
53E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.57370063
54AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.56482439
55CDX2_19796622_ChIP-Seq_MESCs_Mouse1.53456861
56VDR_22108803_ChIP-Seq_LS180_Human1.51750204
57PCGF2_27294783_Chip-Seq_ESCs_Mouse1.51406554
58BRD4_27068464_Chip-Seq_AML-cells_Mouse1.50435578
59STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.48535712
60GATA2_22383799_ChIP-Seq_G1ME_Mouse1.47088501
61PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.45074883
62TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.44553511
63* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.43231396
64GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.43199486
65THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.41032915
66ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.40639838
67TCF7_22412390_ChIP-Seq_EML_Mouse1.39405757
68OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38779491
69PU_27001747_Chip-Seq_BMDM_Mouse1.35742792
70VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.31219184
71BCAT_22108803_ChIP-Seq_LS180_Human1.31184553
72Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.27767430
73SUZ12_27294783_Chip-Seq_NPCs_Mouse1.26227367
74SMAD4_21799915_ChIP-Seq_A2780_Human1.25945011
75EZH2_27294783_Chip-Seq_NPCs_Mouse1.25609322
76P300_19829295_ChIP-Seq_ESCs_Human1.25519977
77GATA3_26560356_Chip-Seq_TH2_Human1.23164909
78CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.22633981
79IGF1R_20145208_ChIP-Seq_DFB_Human1.22479577
80SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22320695
81NFE2_27457419_Chip-Seq_LIVER_Mouse1.20194336
82STAT3_23295773_ChIP-Seq_U87_Human1.19724691
83MAF_26560356_Chip-Seq_TH2_Human1.18755090
84FLI1_27457419_Chip-Seq_LIVER_Mouse1.18735895
85CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.18611090
86CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.17297746
87* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17292856
88TAF15_26573619_Chip-Seq_HEK293_Human1.17231259
89TCF4_23295773_ChIP-Seq_U87_Human1.17213476
90SPI1_23127762_ChIP-Seq_K562_Human1.15991515
91PIAS1_25552417_ChIP-Seq_VCAP_Human1.15820811
92TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.15748648
93CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.14773672
94UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.14307848
95NANOG_18555785_Chip-Seq_ESCs_Mouse1.12259967
96PRDM14_20953172_ChIP-Seq_ESCs_Human1.11702142
97EGR1_19032775_ChIP-ChIP_M12_Human1.11294768
98MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.10700243
99BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.10652726
100CRX_20693478_ChIP-Seq_RETINA_Mouse1.10414530
101TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.10251201
102FLI1_21867929_ChIP-Seq_TH2_Mouse1.10121884
103GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08336638
104CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07277674
105OCT4_21477851_ChIP-Seq_ESCs_Mouse1.06957870
106SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.06514751
107CTBP2_25329375_ChIP-Seq_LNCAP_Human1.06341029
108HOXB4_20404135_ChIP-ChIP_EML_Mouse1.06123684
109RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.05846411
110PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05397755
111EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.04856368
112AR_25329375_ChIP-Seq_VCAP_Human1.04133450
113EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04129237
114GATA1_19941827_ChIP-Seq_MEL_Mouse1.03717621
115ELK3_25401928_ChIP-Seq_HUVEC_Human1.03424878
116CDX2_22108803_ChIP-Seq_LS180_Human1.03150530
117SALL1_21062744_ChIP-ChIP_HESCs_Human1.02009761
118CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01981079
119SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.01966561
120PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01321971
121GATA2_21666600_ChIP-Seq_HMVEC_Human1.01173121
122* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.00422981
123* CBP_20019798_ChIP-Seq_JUKART_Human1.00422981
124CMYC_18555785_Chip-Seq_ESCs_Mouse1.00288009
125P53_22387025_ChIP-Seq_ESCs_Mouse0.99210663
126SALL4_22934838_ChIP-ChIP_CD34+_Human0.98996849
127CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98712464
128TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.98541862
129E2F1_18555785_Chip-Seq_ESCs_Mouse0.98445647
130VDR_24787735_ChIP-Seq_THP-1_Human0.97281858
131FOXA1_21572438_ChIP-Seq_LNCaP_Human0.96456770
132CTBP1_25329375_ChIP-Seq_LNCAP_Human0.96123560
133SUZ12_18555785_Chip-Seq_ESCs_Mouse0.95448562
134TP63_17297297_ChIP-ChIP_HaCaT_Human0.94591467
135TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92024861
136SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.91439187
137SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89423939
138KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.88820254
139STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.88336021
140KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.85927195
141GATA1_22383799_ChIP-Seq_G1ME_Mouse0.85607072
142PU.1_20513432_ChIP-Seq_Bcells_Mouse0.84606857
143SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.84055078
144ERG_20887958_ChIP-Seq_HPC-7_Mouse0.82833344
145NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.80114655
146GATA2_19941826_ChIP-Seq_K562_Human0.78490366
147GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.78459191
148IKZF1_21737484_ChIP-ChIP_HCT116_Human0.77897461
149KDM2B_26808549_Chip-Seq_DND41_Human0.76982133
150CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.76676719
151RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.74139477
152CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.72852593
153SRY_22984422_ChIP-ChIP_TESTIS_Rat0.71555052
154KDM2B_26808549_Chip-Seq_SUP-B15_Human0.71435624
155FOXO3_23340844_ChIP-Seq_DLD1_Human0.69960505
156* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.69636571
157CTCF_26484167_Chip-Seq_Bcells_Mouse0.67644161
158SOX2_20726797_ChIP-Seq_SW620_Human0.66948519
159P300_27268052_Chip-Seq_Bcells_Human0.65398626
160PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.63588028
161SMRT_27268052_Chip-Seq_Bcells_Human0.62944470
162ETS1_22383799_ChIP-Seq_G1ME_Mouse0.61417550

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.05911792
2MP0000685_abnormal_immune_system4.60755116
3MP0002254_reproductive_system_inflammat4.20625057
4MP0001835_abnormal_antigen_presentation4.15318787
5MP0009785_altered_susceptibility_to3.95261810
6MP0003763_abnormal_thymus_physiology3.93435258
7MP0003724_increased_susceptibility_to3.71781190
8MP0006082_CNS_inflammation3.43013776
9MP0001873_stomach_inflammation2.91550893
10MP0000569_abnormal_digit_pigmentation2.89465939
11MP0001800_abnormal_humoral_immune2.82429738
12MP0005670_abnormal_white_adipose2.79758253
13MP0005000_abnormal_immune_tolerance2.71109934
14MP0001790_abnormal_immune_system2.70788094
15MP0005387_immune_system_phenotype2.70788094
16MP0005025_abnormal_response_to2.69199590
17MP0002723_abnormal_immune_serum2.53323206
18MP0005171_absent_coat_pigmentation2.49585216
19MP0002405_respiratory_system_inflammati2.47774363
20MP0004510_myositis2.45562502
21MP0002420_abnormal_adaptive_immunity2.41333103
22MP0001819_abnormal_immune_cell2.40529446
23MP0005187_abnormal_penis_morphology2.35582895
24MP0002452_abnormal_antigen_presenting2.34418860
25MP0003787_abnormal_imprinting2.34248305
26MP0003136_yellow_coat_color2.31406473
27MP0002166_altered_tumor_susceptibility2.19212568
28MP0005310_abnormal_salivary_gland2.18524261
29MP0000015_abnormal_ear_pigmentation2.15508532
30MP0002398_abnormal_bone_marrow2.14714318
31MP0009333_abnormal_splenocyte_physiolog2.13189075
32MP0010155_abnormal_intestine_physiology2.12081000
33MP0003436_decreased_susceptibility_to2.11198121
34MP0008877_abnormal_DNA_methylation2.08087585
35MP0000716_abnormal_immune_system2.02139085
36MP0005464_abnormal_platelet_physiology1.93852873
37MP0003172_abnormal_lysosome_physiology1.91047315
38MP0002419_abnormal_innate_immunity1.90446794
39* MP0002148_abnormal_hypersensitivity_rea1.87450425
40MP0003045_fibrosis1.85535862
41MP0001348_abnormal_lacrimal_gland1.79561162
42MP0002722_abnormal_immune_system1.76695126
43MP0002006_tumorigenesis1.76379315
44MP0001845_abnormal_inflammatory_respons1.74431296
45MP0000703_abnormal_thymus_morphology1.70520418
46MP0003448_altered_tumor_morphology1.61203572
47MP0002429_abnormal_blood_cell1.59525663
48MP0003866_abnormal_defecation1.59366039
49MP0002876_abnormal_thyroid_physiology1.58664410
50MP0000689_abnormal_spleen_morphology1.53728582
51MP0002933_joint_inflammation1.52891201
52MP0003300_gastrointestinal_ulcer1.50063194
53MP0004947_skin_inflammation1.49986178
54MP0001853_heart_inflammation1.42588888
55MP0001346_abnormal_lacrimal_gland1.40989772
56MP0002396_abnormal_hematopoietic_system1.40467883
57MP0001986_abnormal_taste_sensitivity1.30732334
58MP0008469_abnormal_protein_level1.29741121
59MP0003252_abnormal_bile_duct1.26743470
60MP0001851_eye_inflammation1.26332073
61MP0006054_spinal_hemorrhage1.26129256
62MP0009764_decreased_sensitivity_to1.25853030
63MP0005164_abnormal_response_to1.23695486
64MP0002009_preneoplasia1.22312123
65MP0004883_abnormal_blood_vessel1.22309236
66MP0001533_abnormal_skeleton_physiology1.19307103
67MP0003195_calcinosis1.17826245
68MP0000858_altered_metastatic_potential1.11981527
69MP0002877_abnormal_melanocyte_morpholog1.11701545
70MP0010352_gastrointestinal_tract_polyps1.05994161
71MP0002735_abnormal_chemical_nociception1.02438430
72MP0000371_diluted_coat_color1.00495809
73MP0003303_peritoneal_inflammation0.99608181
74MP0005084_abnormal_gallbladder_morpholo0.99366453
75MP0004484_altered_response_of0.99274003
76MP0009765_abnormal_xenobiotic_induced0.98703075
77MP0002837_dystrophic_cardiac_calcinosis0.94962193
78MP0004808_abnormal_hematopoietic_stem0.93279611
79MP0000465_gastrointestinal_hemorrhage0.91757135
80MP0002928_abnormal_bile_duct0.90878730
81MP0005167_abnormal_blood-brain_barrier0.89910332
82MP0009763_increased_sensitivity_to0.89002628
83MP0003656_abnormal_erythrocyte_physiolo0.88573086
84MP0003183_abnormal_peptide_metabolism0.87038155
85MP0008260_abnormal_autophagy0.85764943
86MP0005645_abnormal_hypothalamus_physiol0.84099970
87MP0002998_abnormal_bone_remodeling0.83433254
88MP0003453_abnormal_keratinocyte_physiol0.82626708
89MP0002019_abnormal_tumor_incidence0.81682181
90MP0003879_abnormal_hair_cell0.81403126
91MP0005408_hypopigmentation0.80672577
92MP0002132_abnormal_respiratory_system0.80481345
93MP0008057_abnormal_DNA_replication0.80128785
94MP0005397_hematopoietic_system_phenotyp0.79942980
95MP0001545_abnormal_hematopoietic_system0.79942980
96MP0005253_abnormal_eye_physiology0.78880759
97MP0004215_abnormal_myocardial_fiber0.78269047
98MP0005165_increased_susceptibility_to0.77944657
99MP0001501_abnormal_sleep_pattern0.76991227
100MP0003638_abnormal_response/metabolism_0.76552889
101MP0010234_abnormal_vibrissa_follicle0.74995716
102MP0001881_abnormal_mammary_gland0.74740567
103MP0002102_abnormal_ear_morphology0.73101546
104MP0005647_abnormal_sex_gland0.72959946
105MP0000490_abnormal_crypts_of0.72381297
106MP0003075_altered_response_to0.71196028
107MP0004264_abnormal_extraembryonic_tissu0.66127835
108* MP0000343_altered_response_to0.65141183
109MP0005166_decreased_susceptibility_to0.64555279
110MP0002095_abnormal_skin_pigmentation0.64273206
111MP0006072_abnormal_retinal_apoptosis0.63611826
112MP0009278_abnormal_bone_marrow0.63428866
113MP0002138_abnormal_hepatobiliary_system0.62687536
114MP0003690_abnormal_glial_cell0.62544766
115MP0000230_abnormal_systemic_arterial0.58645779
116MP0005023_abnormal_wound_healing0.58626297
117MP0002277_abnormal_respiratory_mucosa0.58471252
118MP0003828_pulmonary_edema0.57610309
119MP0001764_abnormal_homeostasis0.54348681
120MP0001663_abnormal_digestive_system0.54020447
121MP0002136_abnormal_kidney_physiology0.53620220
122MP0005174_abnormal_tail_pigmentation0.53001634
123MP0000249_abnormal_blood_vessel0.52956894
124MP0000604_amyloidosis0.51231336
125MP0004381_abnormal_hair_follicle0.51230326
126MP0009384_cardiac_valve_regurgitation0.48941397
127MP0000372_irregular_coat_pigmentation0.48039858
128MP0001243_abnormal_dermal_layer0.47725657
129MP0008007_abnormal_cellular_replicative0.46885740
130MP0008058_abnormal_DNA_repair0.46716324
131MP0003806_abnormal_nucleotide_metabolis0.45441878
132MP0005075_abnormal_melanosome_morpholog0.45366823
133MP0002693_abnormal_pancreas_physiology0.44198334
134MP0003795_abnormal_bone_structure0.43516480
135MP0005390_skeleton_phenotype0.43312080

Predicted human phenotypes

RankGene SetZ-score
1Recurrent cutaneous fungal infections (HP:0011370)6.19816177
2Chronic mucocutaneous candidiasis (HP:0002728)6.19816177
3Eczematoid dermatitis (HP:0000976)6.05289877
4Myositis (HP:0100614)5.67665703
5Severe combined immunodeficiency (HP:0004430)5.53325894
6Recurrent fungal infections (HP:0002841)5.40889185
7Optic neuritis (HP:0100653)5.24193343
8Retrobulbar optic neuritis (HP:0100654)5.24193343
9Keratoconjunctivitis (HP:0001096)5.11480639
10Orchitis (HP:0100796)5.01553930
11Combined immunodeficiency (HP:0005387)4.77379262
12T lymphocytopenia (HP:0005403)4.30836846
13Panhypogammaglobulinemia (HP:0003139)4.27493226
14Abnormality of T cell number (HP:0011839)4.26478809
15Recurrent bronchitis (HP:0002837)4.14169885
16Increased IgE level (HP:0003212)4.13771031
17Abnormality of T cells (HP:0002843)4.11004228
18IgG deficiency (HP:0004315)3.94420934
19Recurrent skin infections (HP:0001581)3.93322042
20Elevated erythrocyte sedimentation rate (HP:0003565)3.89686103
21Abnormality of T cell physiology (HP:0011840)3.88916968
22Stomatitis (HP:0010280)3.88367424
23Thyroiditis (HP:0100646)3.70973171
24Abnormal delayed hypersensitivity skin test (HP:0002963)3.65774262
25Increased IgM level (HP:0003496)3.61073252
26IgM deficiency (HP:0002850)3.57402296
27Keratoconjunctivitis sicca (HP:0001097)3.56100995
28Vasculitis (HP:0002633)3.49982912
29Agammaglobulinemia (HP:0004432)3.47839011
30Recurrent abscess formation (HP:0002722)3.35822893
31Pulmonary infiltrates (HP:0002113)3.34886160
32Nasal polyposis (HP:0100582)3.28283914
33Meningitis (HP:0001287)3.27233495
34Encephalitis (HP:0002383)3.19535908
35Abnormality of eosinophils (HP:0001879)3.17583167
36Hemoptysis (HP:0002105)3.16484894
37Recurrent viral infections (HP:0004429)3.15374406
38Pustule (HP:0200039)3.09636568
39Hypergammaglobulinemia (HP:0010702)3.07552223
40Type 2 muscle fiber atrophy (HP:0003554)3.05558354
41IgA deficiency (HP:0002720)3.04114512
42Inflammation of the large intestine (HP:0002037)3.02660743
43Episodic fever (HP:0001954)3.01375833
44Muscle fiber atrophy (HP:0100295)2.99790875
45Abnormality of the nasal mucosa (HP:0000433)2.98732547
46Stomach cancer (HP:0012126)2.97210999
47Chronic diarrhea (HP:0002028)2.96073210
48Keratitis (HP:0000491)2.95225996
49Recurrent bacterial skin infections (HP:0005406)2.93152171
50Gastrointestinal inflammation (HP:0004386)2.89544747
51Chronic otitis media (HP:0000389)2.89038646
52Joint swelling (HP:0001386)2.88887073
53Thrombocytosis (HP:0001894)2.84582074
54Hematochezia (HP:0002573)2.84554318
55Albinism (HP:0001022)2.82201884
56Hypoplasia of the fovea (HP:0007750)2.82025002
57Aplasia/Hypoplasia of the fovea (HP:0008060)2.82025002
58Autoimmune hemolytic anemia (HP:0001890)2.79246011
59Arterial thrombosis (HP:0004420)2.78235973
60Lymphopenia (HP:0001888)2.76836758
61Abnormality of macrophages (HP:0004311)2.76551611
62Abnormality of B cell number (HP:0010975)2.73688991
63B lymphocytopenia (HP:0010976)2.73688991
64Chest pain (HP:0100749)2.73465070
65Leukocytosis (HP:0001974)2.72046073
66Gingival bleeding (HP:0000225)2.68421116
67Neoplasm of the tracheobronchial system (HP:0100552)2.68122517
68Ocular albinism (HP:0001107)2.65345092
69Abnormality of cells of the lymphoid lineage (HP:0012140)2.62593389
70Aplasia/Hypoplasia of the macula (HP:0008059)2.61801231
71Papilledema (HP:0001085)2.58263432
72Autoimmune thrombocytopenia (HP:0001973)2.57973069
73Spontaneous hematomas (HP:0007420)2.57313289
74Gastrointestinal stroma tumor (HP:0100723)2.55135165
75Alveolar cell carcinoma (HP:0006519)2.52285307
76Hepatitis (HP:0012115)2.51517534
77Mediastinal lymphadenopathy (HP:0100721)2.48227905
78Hypoplasia of the thymus (HP:0000778)2.46307086
79Blue irides (HP:0000635)2.44894132
80Aplasia/Hypoplasia of the spleen (HP:0010451)2.44102300
81Gangrene (HP:0100758)2.39558322
82Aplasia/Hypoplasia affecting the retina (HP:0008061)2.39409856
83Pulmonary embolism (HP:0002204)2.38575461
84Colitis (HP:0002583)2.37792659
85Reduced antithrombin III activity (HP:0001976)2.34401688
86Chronic obstructive pulmonary disease (HP:0006510)2.31428956
87Obstructive lung disease (HP:0006536)2.31428956
88Tubulointerstitial nephritis (HP:0001970)2.29380650
89Hypochromic microcytic anemia (HP:0004840)2.27709205
90Polyneuropathy (HP:0001271)2.25073968
91Prolonged bleeding time (HP:0003010)2.23857181
92Increased CSF protein (HP:0002922)2.23298532
93Generalized hypopigmentation of hair (HP:0011358)2.21893735
94Gingivitis (HP:0000230)2.21637891
95Abnormality of the fovea (HP:0000493)2.21111666
96Interstitial pulmonary disease (HP:0006530)2.18226704
97Asplenia (HP:0001746)2.16519188
98Bronchitis (HP:0012387)2.14229608
99Iris hypopigmentation (HP:0007730)2.13830205
100Epistaxis (HP:0000421)2.13038400
101Vertigo (HP:0002321)2.12621168
102Eosinophilia (HP:0001880)2.11666709
103Lymphoma (HP:0002665)2.11634643
104Granulocytopenia (HP:0001913)2.11406619
105Facial diplegia (HP:0001349)2.10832707
106Hypoalbuminemia (HP:0003073)2.10801047
107Abnormal albumin level (HP:0012116)2.10801047
108Amyloidosis (HP:0011034)2.10585910
109Follicular hyperkeratosis (HP:0007502)2.10445341
110Emphysema (HP:0002097)2.10413738
111Large for gestational age (HP:0001520)2.09749180
112Gastrointestinal infarctions (HP:0005244)2.06658272
113Hypercortisolism (HP:0001578)2.06063558
114Persistence of primary teeth (HP:0006335)2.03944691
115Cellulitis (HP:0100658)2.03569876
116Hyperventilation (HP:0002883)2.02921470
117Abnormality of the pericardium (HP:0001697)2.01669939
118Hemiplegia (HP:0002301)1.97565014
119Gaze-evoked nystagmus (HP:0000640)1.93518632
120Arthralgia (HP:0002829)1.92841822
121Recurrent gram-negative bacterial infections (HP:0005420)1.92248122
122Petechiae (HP:0000967)1.91264267
123Generalized hypopigmentation (HP:0007513)1.90942471
124Abnormality of the neuromuscular junction (HP:0003398)1.89711800
125Fatigable weakness (HP:0003473)1.89711800
126Congenital sensorineural hearing impairment (HP:0008527)1.89708424
127Osteomyelitis (HP:0002754)1.89345886
128Abnormal platelet function (HP:0011869)1.87491481
129Impaired platelet aggregation (HP:0003540)1.87491481
130Hypoproteinemia (HP:0003075)1.84143548
131Alopecia of scalp (HP:0002293)1.83840775
132Widely spaced teeth (HP:0000687)1.83774969
133Anorexia (HP:0002039)1.82206027
134Abnormality of dental color (HP:0011073)1.82081260
135Fair hair (HP:0002286)1.80805025
136Absent speech (HP:0001344)1.80318311
137Abnormality of the pleura (HP:0002103)1.80210390
138Attenuation of retinal blood vessels (HP:0007843)1.79666551
139Abnormality of the prostate (HP:0008775)1.78925807
140Urticaria (HP:0001025)1.78677600
141Papillary thyroid carcinoma (HP:0002895)1.76960609
142Abnormality of the renal cortex (HP:0011035)1.76851847
143Abnormality of the endocardium (HP:0004306)1.76353357
144Hypochromic anemia (HP:0001931)1.74921128

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK6.01564122
2FRK4.99003036
3JAK33.53626106
4ZAP703.37834924
5MAP4K13.34234457
6CLK13.28652892
7MAP3K143.10517879
8IRAK42.84040179
9KDR2.79017497
10IKBKE2.78415189
11TESK22.57389918
12TYK22.55844737
13JAK12.53877299
14TBK12.51786561
15BTK2.44519994
16MAP4K22.41641601
17AKT32.36636459
18FGFR42.30221419
19EPHA32.29733092
20TEC2.29633950
21BUB12.22211071
22NLK2.09047600
23ITK2.00104473
24PIK3CG1.77672061
25KIT1.67379955
26INSRR1.63772054
27IRAK31.61539698
28SRPK11.53922479
29EPHB11.52787688
30SYK1.51719041
31HCK1.44705495
32FGFR31.43326221
33LCK1.43277499
34MUSK1.41845601
35PRPF4B1.41379703
36BLK1.38712100
37NUAK11.35003178
38IKBKB1.34409459
39TGFBR11.29557219
40MAP3K121.24316861
41STK101.19413301
42IRAK11.15087594
43ERBB31.12175494
44ACVR1B1.10821151
45SGK21.10749062
46MAP3K21.08903529
47LRRK21.06501952
48TNK21.02291509
49PINK11.01090886
50PTK2B1.00289669
51SIK31.00218009
52LYN0.98998778
53TESK10.97846426
54PLK20.97419048
55MAP3K130.97320024
56FGR0.97201446
57RIPK40.94840317
58MST40.94458430
59PRKG20.91980152
60MAP3K30.89936720
61PIM10.89298398
62RPS6KA40.88753012
63JAK20.88052538
64MATK0.87816829
65BMPR1B0.87435318
66PRKCQ0.87075450
67CHUK0.84323931
68MAP2K60.83780599
69ERN10.83375481
70PIM20.80984306
71STK38L0.76338395
72MAPKAPK50.76092062
73MAPKAPK30.74359935
74NEK60.73280354
75TAOK30.72660378
76FER0.71754309
77FGFR20.71087874
78CAMKK20.70795730
79HIPK20.69639105
80TRPM70.69554953
81TIE10.67180724
82MAPK130.66971611
83PAK30.65739939
84TGFBR20.65702808
85SGK30.65403134
86EEF2K0.64740603
87EIF2AK30.63286391
88GRK60.62759643
89MYLK0.61817038
90STK240.59904925
91MARK30.59770874
92TSSK60.59648934
93ADRBK10.58786965
94DAPK20.57180125
95NEK90.55908752
96MAP3K10.54298591
97CSF1R0.53010135
98CSK0.52670097
99DYRK30.52580211
100OXSR10.52561830
101MAP3K40.51175050
102MAPK70.48279534
103PRKCH0.47750549
104LIMK10.47102247
105PDK10.46948076
106STK380.46574443
107STK30.44859810
108STK110.44662737
109IRAK20.43237347
110PRKCE0.42388568
111CAMK40.42109073
112CDK90.41375718
113LATS10.40764255
114GRK70.40473882
115ARAF0.39986673
116BMPR20.39816919
117IGF1R0.39602422
118STK40.38674164
119EGFR0.36760637
120ERBB20.36069380
121WNK30.34391616
122MAP2K30.33638352
123SGK4940.33294412
124SGK2230.33294412
125SRC0.32937909
126RPS6KA50.32016363
127PRKAA20.31461291
128ABL10.29158425
129DAPK30.29116670
130PDGFRB0.28848600
131RAF10.28484520
132FES0.28278703
133PRKCD0.28250539
134SCYL20.27435762
135MAPK150.26716691
136CDK60.26469660
137YES10.26269981
138FYN0.26201377
139CDK30.25812606
140ADRBK20.25343152
141INSR0.25047249
142RPS6KB20.19633481
143MAPKAPK20.19478236
144MAPK30.18940268
145SIK20.18697712
146BCKDK0.18472502
147FLT30.17574331

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.37860337
2Graft-versus-host disease_Homo sapiens_hsa053324.08977328
3Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.92977825
4Antigen processing and presentation_Homo sapiens_hsa046123.59166688
5Intestinal immune network for IgA production_Homo sapiens_hsa046723.18858081
6Allograft rejection_Homo sapiens_hsa053303.12648798
7Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.04081170
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.76738840
9Asthma_Homo sapiens_hsa053102.61238384
10Measles_Homo sapiens_hsa051622.49841769
11Leishmaniasis_Homo sapiens_hsa051402.48404591
12T cell receptor signaling pathway_Homo sapiens_hsa046602.46274252
13Jak-STAT signaling pathway_Homo sapiens_hsa046302.08196630
14Osteoclast differentiation_Homo sapiens_hsa043802.06374196
15Autoimmune thyroid disease_Homo sapiens_hsa053202.05884542
16RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.94618538
17Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.91265560
18Dorso-ventral axis formation_Homo sapiens_hsa043201.77836278
19Hematopoietic cell lineage_Homo sapiens_hsa046401.73594718
20B cell receptor signaling pathway_Homo sapiens_hsa046621.71257979
21Chemokine signaling pathway_Homo sapiens_hsa040621.60718966
22Toxoplasmosis_Homo sapiens_hsa051451.56387953
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.55162731
24NOD-like receptor signaling pathway_Homo sapiens_hsa046211.39858816
25Herpes simplex infection_Homo sapiens_hsa051681.31366223
26Regulation of autophagy_Homo sapiens_hsa041401.30779651
27Viral myocarditis_Homo sapiens_hsa054161.29643902
28Malaria_Homo sapiens_hsa051441.25039621
29Influenza A_Homo sapiens_hsa051641.19899759
30Staphylococcus aureus infection_Homo sapiens_hsa051501.19848146
31Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.19245452
32Toll-like receptor signaling pathway_Homo sapiens_hsa046201.19169898
33Leukocyte transendothelial migration_Homo sapiens_hsa046701.15951829
34Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.14105128
35Pancreatic cancer_Homo sapiens_hsa052121.13816039
36Phagosome_Homo sapiens_hsa041451.13791027
37Legionellosis_Homo sapiens_hsa051341.11192606
38Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.05933581
39TNF signaling pathway_Homo sapiens_hsa046681.04355965
40Apoptosis_Homo sapiens_hsa042101.03668194
41Pertussis_Homo sapiens_hsa051330.98995079
42Shigellosis_Homo sapiens_hsa051310.95263036
43Hepatitis B_Homo sapiens_hsa051610.94028199
44Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.92148067
45Type I diabetes mellitus_Homo sapiens_hsa049400.92032619
46Tuberculosis_Homo sapiens_hsa051520.90233470
47Lysosome_Homo sapiens_hsa041420.89671411
48Phototransduction_Homo sapiens_hsa047440.87535756
49Renin secretion_Homo sapiens_hsa049240.86309604
50HTLV-I infection_Homo sapiens_hsa051660.85459119
51Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.85376111
52Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.84764739
53Rheumatoid arthritis_Homo sapiens_hsa053230.84326582
54VEGF signaling pathway_Homo sapiens_hsa043700.84216613
55* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.82708892
56Transcriptional misregulation in cancer_Homo sapiens_hsa052020.82198000
57Platelet activation_Homo sapiens_hsa046110.81358882
58Prolactin signaling pathway_Homo sapiens_hsa049170.80717167
59Acute myeloid leukemia_Homo sapiens_hsa052210.80654285
60Collecting duct acid secretion_Homo sapiens_hsa049660.79349202
61Salmonella infection_Homo sapiens_hsa051320.78402014
62Carbohydrate digestion and absorption_Homo sapiens_hsa049730.75670104
63Non-small cell lung cancer_Homo sapiens_hsa052230.75517818
64Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.75404546
65AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.73800174
66Hepatitis C_Homo sapiens_hsa051600.73670575
67Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71998776
68Epstein-Barr virus infection_Homo sapiens_hsa051690.71766698
69Sphingolipid metabolism_Homo sapiens_hsa006000.70814487
70Ether lipid metabolism_Homo sapiens_hsa005650.69265272
71Inositol phosphate metabolism_Homo sapiens_hsa005620.68643795
72alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.67549371
73African trypanosomiasis_Homo sapiens_hsa051430.66285914
74Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.65069879
75Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.63654099
76Salivary secretion_Homo sapiens_hsa049700.63011483
77Type II diabetes mellitus_Homo sapiens_hsa049300.60291663
78Insulin resistance_Homo sapiens_hsa049310.59616811
79Ribosome_Homo sapiens_hsa030100.58154406
80Olfactory transduction_Homo sapiens_hsa047400.57439941
81Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.56940627
82Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.56316920
83Linoleic acid metabolism_Homo sapiens_hsa005910.53935296
84Endocytosis_Homo sapiens_hsa041440.51776031
85Nitrogen metabolism_Homo sapiens_hsa009100.51219309
86Proteasome_Homo sapiens_hsa030500.50637669
87GnRH signaling pathway_Homo sapiens_hsa049120.49312846
88Neurotrophin signaling pathway_Homo sapiens_hsa047220.48630151
89Pentose phosphate pathway_Homo sapiens_hsa000300.48185785
90Regulation of actin cytoskeleton_Homo sapiens_hsa048100.47880374
91Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47411963
92Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46872435
93p53 signaling pathway_Homo sapiens_hsa041150.46587261
94Chronic myeloid leukemia_Homo sapiens_hsa052200.45655590
95Glycosaminoglycan degradation_Homo sapiens_hsa005310.45123591
96Circadian rhythm_Homo sapiens_hsa047100.44909092
97Prostate cancer_Homo sapiens_hsa052150.44694447
98cGMP-PKG signaling pathway_Homo sapiens_hsa040220.43931365
99Fatty acid biosynthesis_Homo sapiens_hsa000610.42872842
100Vascular smooth muscle contraction_Homo sapiens_hsa042700.41498901
101mTOR signaling pathway_Homo sapiens_hsa041500.41185243
102SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40202361
103Galactose metabolism_Homo sapiens_hsa000520.40146015
104ABC transporters_Homo sapiens_hsa020100.40142337
105Viral carcinogenesis_Homo sapiens_hsa052030.39633788
106Long-term depression_Homo sapiens_hsa047300.38380355
107Arachidonic acid metabolism_Homo sapiens_hsa005900.36589273
108Rap1 signaling pathway_Homo sapiens_hsa040150.36327207
109Amoebiasis_Homo sapiens_hsa051460.36152581
110cAMP signaling pathway_Homo sapiens_hsa040240.36055206
111Small cell lung cancer_Homo sapiens_hsa052220.35444178
112Base excision repair_Homo sapiens_hsa034100.35200210
113Pathways in cancer_Homo sapiens_hsa052000.32228061
114Colorectal cancer_Homo sapiens_hsa052100.31215012
115Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.30915485
116Pentose and glucuronate interconversions_Homo sapiens_hsa000400.27069237
117Ras signaling pathway_Homo sapiens_hsa040140.26081718
118Histidine metabolism_Homo sapiens_hsa003400.25635537
119Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.23812988
120Phosphatidylinositol signaling system_Homo sapiens_hsa040700.23753882
121Sphingolipid signaling pathway_Homo sapiens_hsa040710.22671621
122MAPK signaling pathway_Homo sapiens_hsa040100.21724404
123PI3K-Akt signaling pathway_Homo sapiens_hsa041510.20354918
124Other glycan degradation_Homo sapiens_hsa005110.19560210
125Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.18252888
126Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.17781692
127FoxO signaling pathway_Homo sapiens_hsa040680.15417231
128Notch signaling pathway_Homo sapiens_hsa043300.15366613
129Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.13427065
130HIF-1 signaling pathway_Homo sapiens_hsa040660.12386783
131Focal adhesion_Homo sapiens_hsa045100.12141844
132Adherens junction_Homo sapiens_hsa045200.11541070
133RNA degradation_Homo sapiens_hsa030180.10220756
134Caffeine metabolism_Homo sapiens_hsa002320.09175359
135Phospholipase D signaling pathway_Homo sapiens_hsa040720.07680413

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