ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	5.36628753
2	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.97819993
3	cellular ketone body metabolic process (GO:0046950)	4.74167204
4	ATP synthesis coupled proton transport (GO:0015986)	4.66080429
5	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.66080429
6	respiratory electron transport chain (GO:0022904)	4.57692062
7	electron transport chain (GO:0022900)	4.54315201
8	positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:00357	4.54312001
9	L-phenylalanine metabolic process (GO:0006558)	4.52690091
10	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	4.52690091
11	respiratory chain complex IV assembly (GO:0008535)	4.43819815
12	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	4.35190864
13	L-phenylalanine catabolic process (GO:0006559)	4.35190864
14	regulation of type B pancreatic cell apoptotic process (GO:2000674)	4.28431106
15	ketone body metabolic process (GO:1902224)	4.24313010
16	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)	4.22697104
17	negative regulation of execution phase of apoptosis (GO:1900118)	4.13428477
18	cytochrome complex assembly (GO:0017004)	4.11155171
19	peptide hormone processing (GO:0016486)	3.79728893
20	inositol phosphate dephosphorylation (GO:0046855)	3.74159715
21	phosphorylated carbohydrate dephosphorylation (GO:0046838)	3.74159715
22	inositol phosphate catabolic process (GO:0071545)	3.72008477
23	endocrine pancreas development (GO:0031018)	3.67742302
24	nitric oxide biosynthetic process (GO:0006809)	3.66247653
25	protein neddylation (GO:0045116)	3.64814085
26	retinol metabolic process (GO:0042572)	3.64604476
27	auditory receptor cell differentiation (GO:0042491)	3.63510687
28	insulin secretion (GO:0030073)	3.59450867
29	energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)	3.54656830
30	ATP hydrolysis coupled proton transport (GO:0015991)	3.54656830
31	hydrogen ion transmembrane transport (GO:1902600)	3.48044894
32	xenobiotic catabolic process (GO:0042178)	3.45493152
33	phenol-containing compound catabolic process (GO:0019336)	3.43865878
34	signal peptide processing (GO:0006465)	3.40585645
35	positive regulation of gluconeogenesis (GO:0045722)	3.27209736
36	sensory perception of smell (GO:0007608)	3.24943264
37	glycerophospholipid catabolic process (GO:0046475)	3.21288922
38	regulation of extracellular matrix disassembly (GO:0010715)	3.19835428
39	regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:1902235	3.19825964
40	positive regulation of insulin secretion (GO:0032024)	3.18153954
41	intestinal epithelial cell development (GO:0060576)	3.14391101
42	proton transport (GO:0015992)	3.12432028
43	ATP biosynthetic process (GO:0006754)	3.11839200
44	epithelial cell fate commitment (GO:0072148)	3.10804459
45	regulation of hexokinase activity (GO:1903299)	3.09695609
46	regulation of glucokinase activity (GO:0033131)	3.09695609
47	sphingomyelin metabolic process (GO:0006684)	3.09003592
48	pteridine-containing compound biosynthetic process (GO:0042559)	3.08507613
49	hydrogen transport (GO:0006818)	3.06537337
50	GDP-mannose metabolic process (GO:0019673)	3.06110427
51	central nervous system myelination (GO:0022010)	3.03791035
52	axon ensheathment in central nervous system (GO:0032291)	3.03791035
53	glandular epithelial cell differentiation (GO:0002067)	3.01764182
54	positive regulation of calcium ion import (GO:0090280)	3.00302217
55	NADH metabolic process (GO:0006734)	2.98174764
56	glutathione derivative biosynthetic process (GO:1901687)	2.96727717
57	glutathione derivative metabolic process (GO:1901685)	2.96727717
58	polyol catabolic process (GO:0046174)	2.95568403
59	macroautophagy (GO:0016236)	2.95452251
60	bundle of His cell to Purkinje myocyte communication (GO:0086069)	2.93633652
61	neuronal action potential (GO:0019228)	2.92321512
62	negative regulation of complement activation (GO:0045916)	2.90459476
63	C-terminal protein lipidation (GO:0006501)	2.90412144
64	potassium ion export (GO:0071435)	2.86793639
65	protein complex biogenesis (GO:0070271)	2.86587963
66	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.85862121
67	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.85132163
68	platelet dense granule organization (GO:0060155)	2.81589988
69	nitric oxide mediated signal transduction (GO:0007263)	2.80429291
70	glutathione biosynthetic process (GO:0006750)	2.79493362
71	regulation of oxidative phosphorylation (GO:0002082)	2.78249477
72	detection of calcium ion (GO:0005513)	2.78230451
73	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	2.76408106
74	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	2.76408106
75	transferrin transport (GO:0033572)	2.76293653
76	phosphatidylserine acyl-chain remodeling (GO:0036150)	2.75150460
77	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	2.74004702
78	protein localization to cilium (GO:0061512)	2.72814923
79	phenylpropanoid metabolic process (GO:0009698)	2.72273544
80	epithelial cilium movement (GO:0003351)	2.71455422
81	inositol phosphate-mediated signaling (GO:0048016)	2.71098236
82	oxidative phosphorylation (GO:0006119)	2.70115732
83	dopamine biosynthetic process (GO:0042416)	2.69771138
84	peptide hormone secretion (GO:0030072)	2.69590842
85	regulation of autophagic vacuole assembly (GO:2000785)	2.69448846
86	inner mitochondrial membrane organization (GO:0007007)	2.69083874
87	aromatic amino acid family catabolic process (GO:0009074)	2.68656486
88	nonribosomal peptide biosynthetic process (GO:0019184)	2.68332912
89	phosphatidylserine metabolic process (GO:0006658)	2.65286589
90	peptide secretion (GO:0002790)	2.64853575
91	glucosamine-containing compound catabolic process (GO:1901072)	2.64416934
92	positive regulation of histone H3-K4 methylation (GO:0051571)	2.63614401
93	axoneme assembly (GO:0035082)	2.62128300
94	C-terminal protein amino acid modification (GO:0018410)	2.61781909
95	positive regulation of peptide hormone secretion (GO:0090277)	2.60559198
96	trivalent inorganic cation transport (GO:0072512)	2.60183544
97	ferric iron transport (GO:0015682)	2.60183544
98	regulation of insulin secretion involved in cellular response to glucose stimulus (GO:0061178)	2.57830326
99	succinate metabolic process (GO:0006105)	2.56804732
100	response to water (GO:0009415)	2.56580361
101	primary alcohol metabolic process (GO:0034308)	2.54223167
102	negative regulation of protein activation cascade (GO:2000258)	2.54097629
103	lactate metabolic process (GO:0006089)	2.53322532
104	regulation of guanylate cyclase activity (GO:0031282)	2.52448411
105	chaperone-mediated protein transport (GO:0072321)	2.51600766
106	neurotransmitter catabolic process (GO:0042135)	2.51244985
107	sensory perception of chemical stimulus (GO:0007606)	2.50948083
108	regulation of execution phase of apoptosis (GO:1900117)	2.50941245
109	keratinocyte development (GO:0003334)	2.50237380
110	preassembly of GPI anchor in ER membrane (GO:0016254)	2.49387402
111	mitochondrial respiratory chain complex assembly (GO:0033108)	2.49184539
112	positive regulation of peptide secretion (GO:0002793)	2.48766355
113	nodal signaling pathway (GO:0038092)	2.47437565
114	regulation of vacuole organization (GO:0044088)	2.47328837
115	negative regulation of microtubule polymerization (GO:0031115)	2.47199192
116	adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)	2.46483056
117	membrane repolarization during action potential (GO:0086011)	2.46061654
118	NADH dehydrogenase complex assembly (GO:0010257)	2.45813630
119	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.45813630
120	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.45813630
121	cytidine metabolic process (GO:0046087)	2.45634751
122	cytidine catabolic process (GO:0006216)	2.45634751
123	cytidine deamination (GO:0009972)	2.45634751
124	catechol-containing compound biosynthetic process (GO:0009713)	2.43731229
125	catecholamine biosynthetic process (GO:0042423)	2.43731229
126	positive regulation of TOR signaling (GO:0032008)	2.43212031
127	regulation of mitochondrial translation (GO:0070129)	2.42293409
128	regulation of cilium movement (GO:0003352)	2.42071707
129	regulation of protein targeting to membrane (GO:0090313)	2.41623121
130	alditol phosphate metabolic process (GO:0052646)	2.41596525
131	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.41179831
132	cilium movement (GO:0003341)	2.41171079
133	detection of temperature stimulus involved in sensory perception of pain (GO:0050965)	2.40463912
134	detection of temperature stimulus involved in sensory perception (GO:0050961)	2.40463912
135	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	2.38836531
136	regulation of heart rate by cardiac conduction (GO:0086091)	2.38466693
137	peptide transport (GO:0015833)	2.38147973
138	neurotransmitter biosynthetic process (GO:0042136)	2.37284912
139	regulation of insulin secretion (GO:0050796)	2.36530235
140	ER overload response (GO:0006983)	2.36240866
141	L-alpha-amino acid transmembrane transport (GO:1902475)	2.35789185
142	peptide biosynthetic process (GO:0043043)	2.35417205
143	negative regulation of humoral immune response (GO:0002921)	2.35090223
144	peptide metabolic process (GO:0006518)	2.34720460
145	positive regulation of glycolytic process (GO:0045821)	2.34543804
146	cobalamin metabolic process (GO:0009235)	2.33614328
147	basic amino acid transport (GO:0015802)	2.33354871
148	ventricular cardiac muscle cell action potential (GO:0086005)	2.32973564
149	establishment of melanosome localization (GO:0032401)	2.32021283
150	melanosome transport (GO:0032402)	2.31270703
151	digestion (GO:0007586)	2.30491762
152	pyrimidine-containing compound transmembrane transport (GO:0072531)	2.30071150
153	actin filament depolymerization (GO:0030042)	2.29114813
154	nucleoside triphosphate biosynthetic process (GO:0009142)	2.28761930
155	action potential (GO:0001508)	2.27293446
156	calcium-mediated signaling using intracellular calcium source (GO:0035584)	2.26841980
157	nucleotide-sugar biosynthetic process (GO:0009226)	2.26433545
158	regulation of calcineurin-NFAT signaling cascade (GO:0070884)	2.24299704
159	phosphatidylethanolamine acyl-chain remodeling (GO:0036152)	2.24115851
160	cell communication involved in cardiac conduction (GO:0086065)	2.21657954
161	magnesium ion transport (GO:0015693)	2.20774708
162	establishment of pigment granule localization (GO:0051905)	2.20632678
163	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.19619792
164	pigment granule transport (GO:0051904)	2.19375525
165	membrane repolarization during cardiac muscle cell action potential (GO:0086013)	2.18836594
166	regulation of protein glycosylation (GO:0060049)	2.17756460
167	monovalent inorganic cation transport (GO:0015672)	2.17151419
168	nucleoside diphosphate phosphorylation (GO:0006165)	2.16753220
169	membrane budding (GO:0006900)	2.16584297
170	dopamine metabolic process (GO:0042417)	2.16312886
171	tricarboxylic acid cycle (GO:0006099)	2.15547408
172	neuron cell-cell adhesion (GO:0007158)	2.14236546
173	oligosaccharide catabolic process (GO:0009313)	2.14214069
174	positive regulation of protein targeting to membrane (GO:0090314)	2.13966413
175	water-soluble vitamin biosynthetic process (GO:0042364)	2.13700469
176	intraciliary transport (GO:0042073)	2.13478045
177	negative regulation of cation channel activity (GO:2001258)	2.13103803

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.91921022
2	EZH2_22144423_ChIP-Seq_EOC_Human	2.76052561
3	VDR_22108803_ChIP-Seq_LS180_Human	2.51784670
4	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.45169780
5	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.13792070
6	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.12915963
7	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.98398045
8	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.94631710
9	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.77106563
10	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.75543385
11	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	1.75361239
12	SOX2_27498859_Chip-Seq_STOMACH_Mouse	1.69168468
13	GBX2_23144817_ChIP-Seq_PC3_Human	1.65504922
14	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.61963853
15	HTT_18923047_ChIP-ChIP_STHdh_Human	1.60444206
16	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.60160218
17	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.57785311
18	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.56600829
19	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.55300635
20	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.54954014
21	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.52612334
22	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.50696010
23	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.49692014
24	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.48584798
25	SOX2_20726797_ChIP-Seq_SW620_Human	1.43959178
26	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.43707858
27	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.43707858
28	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.43646949
29	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.43548756
30	FUS_26573619_Chip-Seq_HEK293_Human	1.43275235
31	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.42212107
32	CDX2_22108803_ChIP-Seq_LS180_Human	1.41775842
33	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.41627527
34	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.40585193
35	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.39238844
36	BCAT_22108803_ChIP-Seq_LS180_Human	1.39140611
37	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.36288365
38	REST_21632747_ChIP-Seq_MESCs_Mouse	1.33799855
39	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.32717779
40	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.31977056
41	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.31905514
42	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.30678740
43	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.29252885
44	IGF1R_20145208_ChIP-Seq_DFB_Human	1.28865095
45	TAF15_26573619_Chip-Seq_HEK293_Human	1.28061584
46	ZNF263_19887448_ChIP-Seq_K562_Human	1.27388419
47	AR_25329375_ChIP-Seq_VCAP_Human	1.27069762
48	NR3C1_23031785_ChIP-Seq_PC12_Mouse	1.26232389
49	PHF8_20622853_ChIP-Seq_HELA_Human	1.25942705
50	TP53_22573176_ChIP-Seq_HFKS_Human	1.25471412
51	RXR_22158963_ChIP-Seq_LIVER_Mouse	1.25227174
52	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.25107492
53	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	1.24670048
54	LXR_22158963_ChIP-Seq_LIVER_Mouse	1.24096145
55	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.23117352
56	AR_20517297_ChIP-Seq_VCAP_Human	1.22083734
57	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.20938480
58	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.20888057
59	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.19604591
60	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.18631856
61	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.18581711
62	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.17340111
63	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.17095078
64	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.17095078
65	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.17077497
66	AHR_22903824_ChIP-Seq_MCF-7_Human	1.16140037
67	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.16033216
68	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.15568528
69	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.15117286
70	ER_23166858_ChIP-Seq_MCF-7_Human	1.15076385
71	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.15011515
72	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	1.13977180
73	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.13568171
74	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.13139936
75	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.12009876
76	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.11766743
77	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.11271511
78	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.11038114
79	FOXA1_25552417_ChIP-Seq_VCAP_Human	1.10813308
80	TCF4_22108803_ChIP-Seq_LS180_Human	1.10535680
81	SOX2_18555785_Chip-Seq_ESCs_Mouse	1.10429047
82	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.09656118
83	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.09453571
84	CDX2_20551321_ChIP-Seq_CACO-2_Human	1.08685748
85	RBPJ_21746931_ChIP-Seq_IB4_Human	1.08625247
86	P53_22387025_ChIP-Seq_ESCs_Mouse	1.08525155
87	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.08009941
88	CBP_20019798_ChIP-Seq_JUKART_Human	1.08009941
89	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.06623235
90	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.06316640
91	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.06238911
92	GATA4_25053715_ChIP-Seq_YYC3_Human	1.05406821
93	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.05152252
94	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.05116045
95	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.04965391
96	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.04789710
97	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.04419531
98	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.03800437
99	NFYB_21822215_ChIP-Seq_K562_Human	1.02661232
100	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.02475283
101	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.02147527
102	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	1.01786229
103	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.01779624
104	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.01139643
105	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.00908453
106	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.00904013
107	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.00176375
108	STAT3_23295773_ChIP-Seq_U87_Human	0.99856907
109	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.99539039
110	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	0.99485947
111	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	0.99378061
112	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.98843697
113	EP300_21415370_ChIP-Seq_HL-1_Mouse	0.98635489
114	NFYA_21822215_ChIP-Seq_K562_Human	0.97168478
115	ERG_20517297_ChIP-Seq_VCAP_Human	0.96559267
116	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	0.96111450
117	CTCF_18555785_Chip-Seq_ESCs_Mouse	0.95926647
118	TBL1_22424771_ChIP-Seq_293T_Human	0.95727426
119	CMYC_18555785_Chip-Seq_ESCs_Mouse	0.95274698
120	EST1_17652178_ChIP-ChIP_JURKAT_Human	0.95211587
121	ZNF274_21170338_ChIP-Seq_K562_Hela	0.95180338
122	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.95059747
123	FOXA1_26743006_Chip-Seq_LNCaP-abl_Human	0.94399903
124	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	0.93888036
125	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	0.92661940
126	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	0.92286734
127	NANOG_19829295_ChIP-Seq_ESCs_Human	0.91463276
128	SOX2_19829295_ChIP-Seq_ESCs_Human	0.91463276
129	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.90399035
130	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	0.89601748
131	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.89388494
132	ARNT_22903824_ChIP-Seq_MCF-7_Human	0.89336053
133	CTCF_27219007_Chip-Seq_Bcells_Human	0.89137875
134	DROSHA_22980978_ChIP-Seq_HELA_Human	0.88679077
135	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.87842779
136	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.87767874
137	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	0.87696318
138	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.87229875
139	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	0.85456784
140	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.85454606
141	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.85115545
142	NCOR_22424771_ChIP-Seq_293T_Human	0.83340540
143	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	0.83278834
144	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.83192293
145	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.82640491
146	KLF5_25053715_ChIP-Seq_YYC3_Human	0.82571360
147	SMAD4_21799915_ChIP-Seq_A2780_Human	0.82490291
148	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.82209884
149	RARG_19884340_ChIP-ChIP_MEFs_Mouse	0.81867371
150	OCT4_20526341_ChIP-Seq_ESCs_Human	0.81212296
151	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	0.81045367
152	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	0.80938267
153	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.80916889
154	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.80890192
155	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.79742318
156	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.79109884
157	P300_19829295_ChIP-Seq_ESCs_Human	0.78697162
158	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.78695275
159	GATA3_20176728_ChIP-ChIP_TSCs_Mouse	0.78212946
160	RNF2_27304074_Chip-Seq_ESCs_Mouse	0.76849185
161	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.76340035
162	CTCF_20526341_ChIP-Seq_ESCs_Human	0.76323575
163	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.75731684
164	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	0.75108280

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002139_abnormal_hepatobiliary_system	4.40940873
2	MP0005379_endocrine/exocrine_gland_phen	3.82804575
3	MP0002822_catalepsy	3.30016267
4	MP0004270_analgesia	3.19640310
5	MP0002163_abnormal_gland_morphology	3.08935009
6	MP0004043_abnormal_pH_regulation	3.05882753
7	MP0010386_abnormal_urinary_bladder	2.70983090
8	MP0001984_abnormal_olfaction	2.64531209
9	MP0002734_abnormal_mechanical_nocicepti	2.44712712
10	MP0001944_abnormal_pancreas_morphology	2.42755160
11	MP0003878_abnormal_ear_physiology	2.33047490
12	MP0005377_hearing/vestibular/ear_phenot	2.33047490
13	MP0008004_abnormal_stomach_pH	2.33038055
14	MP0002735_abnormal_chemical_nociception	2.32217244
15	MP0006276_abnormal_autonomic_nervous	2.19275692
16	MP0002693_abnormal_pancreas_physiology	2.16366493
17	MP0002254_reproductive_system_inflammat	2.12578221
18	MP0002837_dystrophic_cardiac_calcinosis	2.07342292
19	MP0003806_abnormal_nucleotide_metabolis	2.06718258
20	MP0005365_abnormal_bile_salt	2.04712537
21	MP0001664_abnormal_digestion	2.03670166
22	MP0001968_abnormal_touch/_nociception	2.02280142
23	MP0002736_abnormal_nociception_after	2.00344284
24	MP0010234_abnormal_vibrissa_follicle	1.95930396
25	MP0010329_abnormal_lipoprotein_level	1.95171600
26	MP0001970_abnormal_pain_threshold	1.88344536
27	MP0001529_abnormal_vocalization	1.86093237
28	MP0003011_delayed_dark_adaptation	1.84964808
29	MP0001905_abnormal_dopamine_level	1.80243313
30	MP0002733_abnormal_thermal_nociception	1.79016601
31	MP0008875_abnormal_xenobiotic_pharmacok	1.77828608
32	MP0004858_abnormal_nervous_system	1.74863268
33	MP0001485_abnormal_pinna_reflex	1.74773527
34	MP0000462_abnormal_digestive_system	1.72086130
35	MP0000538_abnormal_urinary_bladder	1.71733313
36	MP0001986_abnormal_taste_sensitivity	1.70605321
37	MP0005645_abnormal_hypothalamus_physiol	1.69595888
38	MP0001440_abnormal_grooming_behavior	1.65728840
39	MP0002272_abnormal_nervous_system	1.64295061
40	MP0000013_abnormal_adipose_tissue	1.63287399
41	MP0002078_abnormal_glucose_homeostasis	1.58178711
42	MP0005085_abnormal_gallbladder_physiolo	1.56946579
43	MP0001756_abnormal_urination	1.56383372
44	MP0003186_abnormal_redox_activity	1.54006774
45	MP0008260_abnormal_autophagy	1.50519992
46	MP0000372_irregular_coat_pigmentation	1.49433044
47	MP0005220_abnormal_exocrine_pancreas	1.48046459
48	MP0001765_abnormal_ion_homeostasis	1.46810610
49	MP0003195_calcinosis	1.44051538
50	MP0002876_abnormal_thyroid_physiology	1.42908559
51	MP0002909_abnormal_adrenal_gland	1.42438718
52	MP0003787_abnormal_imprinting	1.41194220
53	MP0001666_abnormal_nutrient_absorption	1.40248547
54	MP0003880_abnormal_central_pattern	1.39457049
55	MP0005084_abnormal_gallbladder_morpholo	1.34497089
56	MP0008789_abnormal_olfactory_epithelium	1.34309758
57	MP0003879_abnormal_hair_cell	1.30348686
58	MP0002138_abnormal_hepatobiliary_system	1.29078956
59	MP0001542_abnormal_bone_strength	1.28537294
60	MP0003172_abnormal_lysosome_physiology	1.25639457
61	MP0002064_seizures	1.25109540
62	MP0005535_abnormal_body_temperature	1.24937606
63	MP0009643_abnormal_urine_homeostasis	1.24923520
64	MP0002184_abnormal_innervation	1.23655214
65	MP0004264_abnormal_extraembryonic_tissu	1.22792102
66	MP0005551_abnormal_eye_electrophysiolog	1.22765287
67	MP0005448_abnormal_energy_balance	1.21600120
68	MP0003252_abnormal_bile_duct	1.20065044
69	MP0002638_abnormal_pupillary_reflex	1.19062149
70	MP0006036_abnormal_mitochondrial_physio	1.18971501
71	MP0005636_abnormal_mineral_homeostasis	1.18864740
72	MP0009745_abnormal_behavioral_response	1.18852234
73	MP0003953_abnormal_hormone_level	1.18817240
74	MP0005174_abnormal_tail_pigmentation	1.18803442
75	MP0004147_increased_porphyrin_level	1.18328828
76	MP0002067_abnormal_sensory_capabilities	1.17989449
77	MP0001764_abnormal_homeostasis	1.17379350
78	MP0002118_abnormal_lipid_homeostasis	1.17322604
79	MP0003635_abnormal_synaptic_transmissio	1.17275082
80	MP0005332_abnormal_amino_acid	1.16162743
81	MP0004885_abnormal_endolymph	1.16029767
82	MP0003183_abnormal_peptide_metabolism	1.13015848
83	MP0006082_CNS_inflammation	1.11324521
84	MP0004742_abnormal_vestibular_system	1.11092800
85	MP0008877_abnormal_DNA_methylation	1.10278913
86	MP0002572_abnormal_emotion/affect_behav	1.09686873
87	MP0002277_abnormal_respiratory_mucosa	1.09586478
88	MP0002090_abnormal_vision	1.09515986
89	MP0009046_muscle_twitch	1.08610421
90	MP0005394_taste/olfaction_phenotype	1.08222979
91	MP0005499_abnormal_olfactory_system	1.08222979
92	MP0003329_amyloid_beta_deposits	1.07748685
93	MP0003283_abnormal_digestive_organ	1.07661659
94	MP0009780_abnormal_chondrocyte_physiolo	1.06801255
95	MP0005253_abnormal_eye_physiology	1.06002994
96	MP0004036_abnormal_muscle_relaxation	1.04200295
97	MP0002229_neurodegeneration	1.02373189
98	MP0000751_myopathy	1.01448136
99	MP0002751_abnormal_autonomic_nervous	1.00279068
100	MP0005386_behavior/neurological_phenoty	0.99509623
101	MP0004924_abnormal_behavior	0.99509623
102	MP0005408_hypopigmentation	0.99025363
103	MP0003122_maternal_imprinting	0.98547534
104	MP0004145_abnormal_muscle_electrophysio	0.98282111
105	MP0003315_abnormal_perineum_morphology	0.98012544
106	MP0001501_abnormal_sleep_pattern	0.97590161
107	MP0000537_abnormal_urethra_morphology	0.97156440
108	MP0005646_abnormal_pituitary_gland	0.96990916
109	MP0010678_abnormal_skin_adnexa	0.96985395
110	MP0004133_heterotaxia	0.96659758
111	MP0005410_abnormal_fertilization	0.96577145
112	MP0000631_abnormal_neuroendocrine_gland	0.95615259
113	MP0004019_abnormal_vitamin_homeostasis	0.95455037
114	MP0004215_abnormal_myocardial_fiber	0.95442579
115	MP0008872_abnormal_physiological_respon	0.95233942
116	MP0000639_abnormal_adrenal_gland	0.93911676
117	MP0002557_abnormal_social/conspecific_i	0.93865779
118	MP0002928_abnormal_bile_duct	0.92625706
119	MP0002160_abnormal_reproductive_system	0.92606246
120	MP0000749_muscle_degeneration	0.92277476
121	MP0004484_altered_response_of	0.90939291
122	MP0002063_abnormal_learning/memory/cond	0.90433130
123	MP0006035_abnormal_mitochondrial_morpho	0.89898941
124	MP0005248_abnormal_Harderian_gland	0.89896595
125	MP0001963_abnormal_hearing_physiology	0.89805580
126	MP0001486_abnormal_startle_reflex	0.89337208
127	MP0002295_abnormal_pulmonary_circulatio	0.88309051
128	MP0005381_digestive/alimentary_phenotyp	0.88234647
129	MP0009840_abnormal_foam_cell	0.87127326
130	MP0000747_muscle_weakness	0.87079679
131	MP0003866_abnormal_defecation	0.86829990
132	MP0000003_abnormal_adipose_tissue	0.86559757
133	MP0002938_white_spotting	0.86515965
134	MP0000015_abnormal_ear_pigmentation	0.83980655
135	MP0006072_abnormal_retinal_apoptosis	0.82332517
136	MP0003633_abnormal_nervous_system	0.81012557
137	MP0000778_abnormal_nervous_system	0.80878350
138	MP0005058_abnormal_lysosome_morphology	0.80536672
139	MP0002882_abnormal_neuron_morphology	0.80496260
140	MP0001188_hyperpigmentation	0.80432699
141	MP0004142_abnormal_muscle_tone	0.79714730
142	MP0005075_abnormal_melanosome_morpholog	0.79078282
143	MP0003634_abnormal_glial_cell	0.77512600
144	MP0000230_abnormal_systemic_arterial	0.77223959
145	MP0005319_abnormal_enzyme/_coenzyme	0.77057780
146	MP0004085_abnormal_heartbeat	0.75932088
147	MP0003646_muscle_fatigue	0.74651739
148	MP0002971_abnormal_brown_adipose	0.73642772
149	MP0000427_abnormal_hair_cycle	0.67350532
150	MP0009642_abnormal_blood_homeostasis	0.65536977
151	MP0005452_abnormal_adipose_tissue	0.63183833
152	MP0002136_abnormal_kidney_physiology	0.62734019

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of aromatic amino acid family metabolism (HP:0004338)	4.95972374
2	Acute necrotizing encephalopathy (HP:0006965)	4.68440514
3	Abnormal mitochondria in muscle tissue (HP:0008316)	4.28249505
4	Acute encephalopathy (HP:0006846)	4.08770524
5	Progressive macrocephaly (HP:0004481)	3.97242245
6	Hypothermia (HP:0002045)	3.87342560
7	Mitochondrial inheritance (HP:0001427)	3.78923629
8	Pheochromocytoma (HP:0002666)	3.56510854
9	Myokymia (HP:0002411)	3.53157434
10	Neuroendocrine neoplasm (HP:0100634)	3.28715903
11	Double outlet right ventricle (HP:0001719)	3.23047184
12	Congenital malformation of the right heart (HP:0011723)	3.23047184
13	Increased CSF lactate (HP:0002490)	3.22272698
14	Hyperactive renin-angiotensin system (HP:0000841)	3.18809776
15	Gout (HP:0001997)	3.17593707
16	Hepatocellular necrosis (HP:0001404)	3.17042685
17	Increased CSF protein (HP:0002922)	3.05674041
18	Large for gestational age (HP:0001520)	3.02159870
19	Metabolic alkalosis (HP:0200114)	3.01614098
20	Hyperglycemia (HP:0003074)	2.99229439
21	Hepatic necrosis (HP:0002605)	2.99145732
22	Vascular calcification (HP:0004934)	2.94690301
23	Ketoacidosis (HP:0001993)	2.91255682
24	Limb dystonia (HP:0002451)	2.86892487
25	3-Methylglutaconic aciduria (HP:0003535)	2.85302612
26	Palpitations (HP:0001962)	2.84005139
27	Progressive neurologic deterioration (HP:0002344)	2.82522705
28	Abnormality of vitamin metabolism (HP:0100508)	2.79965949
29	Hypoglycemic coma (HP:0001325)	2.77537301
30	Hypomagnesemia (HP:0002917)	2.70992897
31	Intestinal atresia (HP:0011100)	2.68215775
32	Respiratory failure (HP:0002878)	2.66232605
33	Abnormality of magnesium homeostasis (HP:0004921)	2.65748391
34	Ileus (HP:0002595)	2.63791435
35	Cerebral edema (HP:0002181)	2.61779000
36	Retinal dysplasia (HP:0007973)	2.57117251
37	Hypokinesia (HP:0002375)	2.56585622
38	Hyperinsulinemic hypoglycemia (HP:0000825)	2.55998050
39	Hypokalemic alkalosis (HP:0001949)	2.49485283
40	Vacuolated lymphocytes (HP:0001922)	2.48988506
41	Abnormality of chloride homeostasis (HP:0011422)	2.45720721
42	Cardiovascular calcification (HP:0011915)	2.44661871
43	Postural tremor (HP:0002174)	2.41979985
44	Increased circulating renin level (HP:0000848)	2.41462001
45	Lactic acidosis (HP:0003128)	2.40968174
46	Hyperaldosteronism (HP:0000859)	2.39009854
47	Late onset (HP:0003584)	2.33890198
48	Nuclear cataract (HP:0100018)	2.31768245
49	Abnormality of urine glucose concentration (HP:0011016)	2.30059835
50	Glycosuria (HP:0003076)	2.30059835
51	Ketosis (HP:0001946)	2.29440900
52	Abnormality of renal resorption (HP:0011038)	2.27812203
53	Optic disc pallor (HP:0000543)	2.25832043
54	Leukodystrophy (HP:0002415)	2.25071746
55	Abnormality of renin-angiotensin system (HP:0000847)	2.24777628
56	Syncope (HP:0001279)	2.23923288
57	Elevated circulating parathyroid hormone (PTH) level (HP:0003165)	2.23383454
58	Methylmalonic aciduria (HP:0012120)	2.22918600
59	Abnormal albumin level (HP:0012116)	2.22293159
60	Hypoalbuminemia (HP:0003073)	2.22293159
61	Renal salt wasting (HP:0000127)	2.20974913
62	Generalized aminoaciduria (HP:0002909)	2.19060204
63	Abnormality of liposaccharide metabolism (HP:0010968)	2.18142586
64	Abnormality of glycosphingolipid metabolism (HP:0004343)	2.18142586
65	Abnormality of glycolipid metabolism (HP:0010969)	2.18142586
66	Hyperuricemia (HP:0002149)	2.16624886
67	Increased purine levels (HP:0004368)	2.16624886
68	Pancreatic fibrosis (HP:0100732)	2.16272355
69	Hypokalemia (HP:0002900)	2.16232694
70	Exercise intolerance (HP:0003546)	2.14657605
71	Lethargy (HP:0001254)	2.13456475
72	Tubular atrophy (HP:0000092)	2.11044433
73	Aplasia/hypoplasia of the uterus (HP:0008684)	2.10261834
74	Pancreatic cysts (HP:0001737)	2.08833098
75	Ventricular fibrillation (HP:0001663)	2.08689192
76	Abnormality of vitamin B metabolism (HP:0004340)	2.08457337
77	Increased hepatocellular lipid droplets (HP:0006565)	2.08432442
78	Lipid accumulation in hepatocytes (HP:0006561)	2.07057685
79	Hemiparesis (HP:0001269)	2.06185671
80	Hypoglycemic seizures (HP:0002173)	2.05063766
81	Hyperphosphatemia (HP:0002905)	2.04291023
82	Abnormality of the renal cortex (HP:0011035)	2.03887403
83	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.03878158
84	Abnormality of renal excretion (HP:0011036)	2.03861488
85	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.02703429
86	Abnormality of polysaccharide metabolism (HP:0011012)	2.02410767
87	Abnormality of glycosaminoglycan metabolism (HP:0004371)	2.02410767
88	Abnormality of mucopolysaccharide metabolism (HP:0011020)	2.02410767
89	Exocrine pancreatic insufficiency (HP:0001738)	2.01585118
90	True hermaphroditism (HP:0010459)	2.01379491
91	Chronic bronchitis (HP:0004469)	2.00357251
92	Rhinitis (HP:0012384)	1.99817922
93	Insulin-resistant diabetes mellitus (HP:0000831)	1.99253842
94	Conjunctival hamartoma (HP:0100780)	1.98580203
95	Medial flaring of the eyebrow (HP:0010747)	1.98255500
96	Renal Fanconi syndrome (HP:0001994)	1.98016441
97	Increased serum pyruvate (HP:0003542)	1.97231389
98	Abnormality of glycolysis (HP:0004366)	1.97231389
99	Genital tract atresia (HP:0001827)	1.95994150
100	Atonic seizures (HP:0010819)	1.95891262
101	Gait imbalance (HP:0002141)	1.95754054
102	Abnormal tarsal ossification (HP:0008369)	1.95128615
103	Steatorrhea (HP:0002570)	1.94231908
104	Hyperphosphaturia (HP:0003109)	1.93694869
105	Agitation (HP:0000713)	1.93605687
106	Autoamputation (HP:0001218)	1.92272760
107	Vaginal atresia (HP:0000148)	1.92133819
108	Abnormality of midbrain morphology (HP:0002418)	1.92032975
109	Molar tooth sign on MRI (HP:0002419)	1.92032975
110	Myotonia (HP:0002486)	1.91908103
111	Proximal tubulopathy (HP:0000114)	1.91795530
112	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.91469700
113	Congenital sensorineural hearing impairment (HP:0008527)	1.91060284
114	Urinary glycosaminoglycan excretion (HP:0003541)	1.89937485
115	Mucopolysacchariduria (HP:0008155)	1.89937485
116	Right ventricular cardiomyopathy (HP:0011663)	1.89927590
117	Congenital primary aphakia (HP:0007707)	1.89390450
118	Decreased circulating renin level (HP:0003351)	1.88548888
119	Abnormal respiratory epithelium morphology (HP:0012253)	1.87774931
120	Abnormal respiratory motile cilium morphology (HP:0005938)	1.87774931
121	Abnormal ciliary motility (HP:0012262)	1.87352603
122	Goiter (HP:0000853)	1.86947962
123	Abnormal autonomic nervous system physiology (HP:0012332)	1.86827270
124	Emotional lability (HP:0000712)	1.86668281
125	Nephrogenic diabetes insipidus (HP:0009806)	1.84924004
126	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.84499024
127	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.84499024
128	CNS demyelination (HP:0007305)	1.83460428
129	Polyuria (HP:0000103)	1.83411639
130	Muscle fiber splitting (HP:0003555)	1.83342157
131	Severe visual impairment (HP:0001141)	1.82503589
132	Dysautonomia (HP:0002459)	1.82355984
133	Hyperthyroidism (HP:0000836)	1.82153964
134	Myopathic facies (HP:0002058)	1.81758836
135	Exertional dyspnea (HP:0002875)	1.81443991
136	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.80704387
137	Hypoplasia of the fovea (HP:0007750)	1.80704387
138	Nephronophthisis (HP:0000090)	1.80676386
139	Abnormal urine output (HP:0012590)	1.80672458
140	Increased serum lactate (HP:0002151)	1.79619734
141	Alkalosis (HP:0001948)	1.79539256
142	Congenital ichthyosiform erythroderma (HP:0007431)	1.79306249
143	Hypotension (HP:0002615)	1.77369068
144	Abnormal respiratory motile cilium physiology (HP:0012261)	1.76779613
145	Focal motor seizures (HP:0011153)	1.75123748
146	Increased intramyocellular lipid droplets (HP:0012240)	1.74803451
147	Prolonged QT interval (HP:0001657)	1.74793495
148	X-linked dominant inheritance (HP:0001423)	1.72532073
149	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.71213019
150	Ankle clonus (HP:0011448)	1.70975237
151	Adrenal overactivity (HP:0002717)	1.70713948
152	Dicarboxylic aciduria (HP:0003215)	1.70390272
153	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.70390272
154	Sudden death (HP:0001699)	1.68365379
155	Methylmalonic acidemia (HP:0002912)	1.68290758
156	Abnormality of calcium-phosphate metabolism (HP:0100530)	1.67399056
157	Septate vagina (HP:0001153)	1.67274316
158	Sensory axonal neuropathy (HP:0003390)	1.65548405
159	Increased muscle lipid content (HP:0009058)	1.65407251
160	Abnormal urine phosphate concentration (HP:0012599)	1.64065673

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ARAF	3.67472697
2	EPHA2	3.33799369
3	STK39	2.97333701
4	WNK4	2.85169517
5	NME1	2.76938706
6	MST4	2.69537763
7	OXSR1	2.68797962
8	AKT3	2.32145548
9	MAP4K2	2.28081070
10	MAP2K2	2.25108691
11	CASK	2.22882461
12	WNK3	2.08919319
13	GRK5	2.04299620
14	MAPK15	1.97234224
15	MAP3K12	1.96805576
16	BRAF	1.96331482
17	FGFR2	1.93689261
18	LIMK1	1.84191309
19	LMTK2	1.83662638
20	NTRK1	1.79949241
21	MAP3K2	1.77307347
22	FRK	1.71398305
23	ACVR1B	1.65707273
24	MYLK	1.63620246
25	CAMK2D	1.58159587
26	CAMK2B	1.52590175
27	PHKG2	1.49528162
28	PHKG1	1.49528162
29	STK38L	1.46636852
30	MAPKAPK5	1.44324958
31	CAMK2G	1.42768082
32	STK16	1.42379269
33	TESK1	1.41569338
34	BCR	1.41418957
35	TRIM28	1.35352123
36	PNCK	1.33328651
37	PIK3CA	1.33169310
38	SGK223	1.31757439
39	SGK494	1.31757439
40	MST1R	1.23895776
41	KSR2	1.17645330
42	EIF2AK3	1.16865639
43	MAP2K1	1.15860671
44	PDK2	1.15245703
45	EIF2AK1	1.13533932
46	STK3	1.11111845
47	PIM2	1.10749039
48	TRPM7	1.10580244
49	OBSCN	1.05840690
50	PDK4	1.04602419
51	PDK3	1.04602419
52	PRKCI	1.03958292
53	PRKCE	1.02835134
54	NLK	1.01800739
55	FER	0.98956497
56	FGFR3	0.98027130
57	EPHA3	0.96680929
58	MET	0.94955419
59	CSNK1G3	0.93575524
60	MAP3K9	0.90185090
61	TNIK	0.87498948
62	MAP3K3	0.84591675
63	BMPR2	0.83390879
64	PRKG2	0.82954972
65	TESK2	0.82188078
66	CAMKK2	0.81153919
67	DAPK2	0.79775407
68	GRK7	0.79080732
69	ZAK	0.76754784
70	PINK1	0.76715106
71	PAK3	0.75966071
72	MAPK13	0.75207307
73	BCKDK	0.74799634
74	CAMK2A	0.73114587
75	CSNK1G2	0.71450609
76	MINK1	0.71256043
77	PTK2B	0.71045492
78	TNK2	0.69945153
79	NTRK3	0.67927124
80	DAPK3	0.65902917
81	MARK1	0.65240522
82	PRKG1	0.64782440
83	DAPK1	0.64643036
84	CSNK1G1	0.63904169
85	WNK1	0.63835569
86	MAP2K7	0.63483230
87	STK24	0.62312394
88	NEK1	0.60245218
89	ERBB4	0.57382931
90	BMPR1B	0.56358051
91	DYRK2	0.56256583
92	ERBB3	0.55428798
93	PLK2	0.55045463
94	TAOK1	0.53522741
95	MAP2K4	0.53298700
96	TLK1	0.52860143
97	RIPK1	0.52290819
98	PRKCG	0.52107842
99	PRKD3	0.51700682
100	PDPK1	0.50275827
101	ABL2	0.50067529
102	IRAK1	0.48984385
103	PRKAA2	0.48657381
104	STK4	0.48133248
105	ADRBK2	0.46845878
106	PRKACA	0.44649200
107	CDK14	0.43913531
108	AKT2	0.43754190
109	ROCK2	0.43430399
110	ADRBK1	0.42254023
111	CDK5	0.41423704
112	MAPKAPK3	0.41249955
113	IKBKB	0.40470551
114	SGK2	0.40395202
115	MATK	0.40287319
116	CSNK1A1L	0.39649887
117	INSRR	0.39446334
118	YES1	0.39299710
119	ROCK1	0.38999521
120	RPS6KA2	0.38952243
121	MAP2K6	0.38884995
122	CSNK1A1	0.38375117
123	EPHB2	0.38155075
124	PIK3CG	0.37522902
125	GRK1	0.37403894
126	MUSK	0.36540029
127	MAP3K4	0.36299617
128	PRKCQ	0.35898575
129	STK11	0.35498472
130	PRKAA1	0.35222190
131	MAP3K1	0.35106162
132	PRKCA	0.34422180
133	PKN1	0.34371525
134	MKNK2	0.31278881
135	HIPK2	0.31176414
136	ILK	0.29737530
137	PAK4	0.28096821

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	4.48002595
2	Parkinsons disease_Homo sapiens_hsa05012	3.66256588
3	Sulfur metabolism_Homo sapiens_hsa00920	3.14775373
4	Collecting duct acid secretion_Homo sapiens_hsa04966	3.03824892
5	Alzheimers disease_Homo sapiens_hsa05010	2.82877547
6	Huntingtons disease_Homo sapiens_hsa05016	2.47133943
7	Vibrio cholerae infection_Homo sapiens_hsa05110	2.16100908
8	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.08253700
9	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.99493154
10	Cardiac muscle contraction_Homo sapiens_hsa04260	1.96743026
11	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.92062540
12	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.85524453
13	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.82892634
14	Nitrogen metabolism_Homo sapiens_hsa00910	1.81955036
15	Protein export_Homo sapiens_hsa03060	1.76364119
16	Olfactory transduction_Homo sapiens_hsa04740	1.73335970
17	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.71806219
18	Mineral absorption_Homo sapiens_hsa04978	1.68566015
19	Proteasome_Homo sapiens_hsa03050	1.53568325
20	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.53206659
21	Regulation of autophagy_Homo sapiens_hsa04140	1.46412829
22	Pyruvate metabolism_Homo sapiens_hsa00620	1.46103544
23	Histidine metabolism_Homo sapiens_hsa00340	1.45987883
24	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.44302015
25	Insulin secretion_Homo sapiens_hsa04911	1.41260475
26	Circadian rhythm_Homo sapiens_hsa04710	1.36757411
27	Fatty acid elongation_Homo sapiens_hsa00062	1.27812567
28	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.26250481
29	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.26079733
30	Arginine biosynthesis_Homo sapiens_hsa00220	1.20433398
31	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.19667414
32	Sphingolipid metabolism_Homo sapiens_hsa00600	1.18498789
33	Tryptophan metabolism_Homo sapiens_hsa00380	1.18226380
34	Linoleic acid metabolism_Homo sapiens_hsa00591	1.17449613
35	Selenocompound metabolism_Homo sapiens_hsa00450	1.16731858
36	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.16440559
37	Pancreatic secretion_Homo sapiens_hsa04972	1.12822683
38	Chemical carcinogenesis_Homo sapiens_hsa05204	1.12216855
39	Butanoate metabolism_Homo sapiens_hsa00650	1.11996508
40	Taste transduction_Homo sapiens_hsa04742	1.10641398
41	Propanoate metabolism_Homo sapiens_hsa00640	1.09622890
42	Ether lipid metabolism_Homo sapiens_hsa00565	1.09284354
43	Gastric acid secretion_Homo sapiens_hsa04971	1.07244179
44	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.04954873
45	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.04237908
46	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.03922614
47	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.02895667
48	Retinol metabolism_Homo sapiens_hsa00830	1.02875510
49	Tight junction_Homo sapiens_hsa04530	1.01473160
50	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.00123536
51	Fat digestion and absorption_Homo sapiens_hsa04975	1.00096920
52	Serotonergic synapse_Homo sapiens_hsa04726	0.99847813
53	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.99433566
54	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.98620452
55	Arginine and proline metabolism_Homo sapiens_hsa00330	0.97964706
56	Glutathione metabolism_Homo sapiens_hsa00480	0.96085053
57	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.95692451
58	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.95325098
59	Folate biosynthesis_Homo sapiens_hsa00790	0.94579732
60	Dopaminergic synapse_Homo sapiens_hsa04728	0.93809032
61	GABAergic synapse_Homo sapiens_hsa04727	0.91385269
62	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.90415555
63	Caffeine metabolism_Homo sapiens_hsa00232	0.88602335
64	Steroid biosynthesis_Homo sapiens_hsa00100	0.87503325
65	beta-Alanine metabolism_Homo sapiens_hsa00410	0.86987159
66	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.86104627
67	Amphetamine addiction_Homo sapiens_hsa05031	0.86039081
68	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.84450992
69	Type I diabetes mellitus_Homo sapiens_hsa04940	0.83862302
70	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.83858149
71	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.82852994
72	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.82555852
73	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.80784765
74	Cocaine addiction_Homo sapiens_hsa05030	0.79173572
75	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.77079376
76	Circadian entrainment_Homo sapiens_hsa04713	0.76040766
77	Metabolic pathways_Homo sapiens_hsa01100	0.76033195
78	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.75964242
79	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.75571925
80	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.75466720
81	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.74435686
82	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.74188076
83	Phototransduction_Homo sapiens_hsa04744	0.73442851
84	Salivary secretion_Homo sapiens_hsa04970	0.72172234
85	Tyrosine metabolism_Homo sapiens_hsa00350	0.72078483
86	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.71657303
87	Fatty acid metabolism_Homo sapiens_hsa01212	0.70426719
88	Phenylalanine metabolism_Homo sapiens_hsa00360	0.70335502
89	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.69637172
90	Cholinergic synapse_Homo sapiens_hsa04725	0.69314908
91	Renin-angiotensin system_Homo sapiens_hsa04614	0.66885747
92	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.58182477
93	Morphine addiction_Homo sapiens_hsa05032	0.57662196
94	Glycerolipid metabolism_Homo sapiens_hsa00561	0.56014287
95	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.55787057
96	Glucagon signaling pathway_Homo sapiens_hsa04922	0.55447038
97	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.55170499
98	Carbon metabolism_Homo sapiens_hsa01200	0.54849079
99	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.54667661
100	Bile secretion_Homo sapiens_hsa04976	0.53815392
101	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.51208827
102	Rheumatoid arthritis_Homo sapiens_hsa05323	0.50904491
103	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.50606885
104	Galactose metabolism_Homo sapiens_hsa00052	0.50075555
105	Glutamatergic synapse_Homo sapiens_hsa04724	0.48491801
106	Renin secretion_Homo sapiens_hsa04924	0.45537769
107	Protein digestion and absorption_Homo sapiens_hsa04974	0.44949643
108	Other glycan degradation_Homo sapiens_hsa00511	0.44441884
109	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.44107835
110	Complement and coagulation cascades_Homo sapiens_hsa04610	0.43818998
111	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.42733569
112	Lysosome_Homo sapiens_hsa04142	0.42065403
113	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.41644080
114	RNA polymerase_Homo sapiens_hsa03020	0.41489417
115	Peroxisome_Homo sapiens_hsa04146	0.41362155
116	Nicotine addiction_Homo sapiens_hsa05033	0.40928751
117	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.40248702
118	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.39505092
119	ABC transporters_Homo sapiens_hsa02010	0.39346726
120	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.38321898
121	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.38198279
122	Long-term potentiation_Homo sapiens_hsa04720	0.37657777
123	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.34735939
124	PPAR signaling pathway_Homo sapiens_hsa03320	0.34678278
125	Long-term depression_Homo sapiens_hsa04730	0.34583059
126	Gap junction_Homo sapiens_hsa04540	0.34377009
127	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.31117596
128	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.30447234
129	Fatty acid degradation_Homo sapiens_hsa00071	0.30130491
130	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.29955545

CYSTM1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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