CYTH3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the PSCD (pleckstrin homology, Sec7 and coiled-coil domains) family. PSCD family members have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. This encoded protein is involved in the control of Golgi structure and function, and it may have a physiological role in regulating ADP-ribosylation factor protein 6 (ARF) functions, in addition to acting on ARF1. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vascular endothelial growth factor signaling pathway (GO:0038084)4.46388100
2protein heterotrimerization (GO:0070208)4.19119780
3blood vessel maturation (GO:0001955)4.13016057
4collagen fibril organization (GO:0030199)4.01843623
5neuron projection extension involved in neuron projection guidance (GO:1902284)4.00561644
6axon extension involved in axon guidance (GO:0048846)4.00561644
7lymphangiogenesis (GO:0001946)3.91232982
8hemidesmosome assembly (GO:0031581)3.90091517
9sequestering of extracellular ligand from receptor (GO:0035581)3.84518004
10peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.69163626
11focal adhesion assembly (GO:0048041)3.68723462
12cell-substrate adherens junction assembly (GO:0007045)3.68723462
13cell adhesion mediated by integrin (GO:0033627)3.58276718
14basement membrane organization (GO:0071711)3.57540298
15endodermal cell differentiation (GO:0035987)3.55847393
16plasma membrane repair (GO:0001778)3.52752476
17barbed-end actin filament capping (GO:0051016)3.52416108
18retina vasculature morphogenesis in camera-type eye (GO:0061299)3.48100350
19chondrocyte proliferation (GO:0035988)3.48086497
20negative regulation of fatty acid transport (GO:2000192)3.46888018
21regulation of early endosome to late endosome transport (GO:2000641)3.45972576
22cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.36922254
23wound healing, spreading of epidermal cells (GO:0035313)3.35003220
24virion attachment to host cell (GO:0019062)3.33575636
25adhesion of symbiont to host cell (GO:0044650)3.33575636
26type B pancreatic cell proliferation (GO:0044342)3.32913870
27COPI coating of Golgi vesicle (GO:0048205)3.32371999
28Golgi transport vesicle coating (GO:0048200)3.32371999
29morphogenesis of an endothelium (GO:0003159)3.31637072
30endothelial tube morphogenesis (GO:0061154)3.31637072
31protein retention in ER lumen (GO:0006621)3.26488239
32lymph vessel development (GO:0001945)3.22806191
33protein targeting to plasma membrane (GO:0072661)3.21836616
34regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.21192586
35glomerular basement membrane development (GO:0032836)3.18148703
36adhesion of symbiont to host (GO:0044406)3.15453246
37apoptotic cell clearance (GO:0043277)3.13583649
38maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.13371843
39planar cell polarity pathway involved in neural tube closure (GO:0090179)3.09974403
40substrate adhesion-dependent cell spreading (GO:0034446)3.08808492
41cardiac myofibril assembly (GO:0055003)3.06539955
42stress fiber assembly (GO:0043149)3.02925095
43cellular response to interferon-alpha (GO:0035457)3.01312875
44cell migration involved in heart development (GO:0060973)2.99445180
45hippo signaling (GO:0035329)2.99186916
46negative regulation of chondrocyte differentiation (GO:0032331)2.96798071
47fibroblast migration (GO:0010761)2.94577580
48collagen metabolic process (GO:0032963)2.93233124
49glomerular filtration (GO:0003094)2.93147842
50regulation of macrophage cytokine production (GO:0010935)2.91592103
51extracellular fibril organization (GO:0043206)2.89078192
52regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.88526057
53coronary vasculature morphogenesis (GO:0060977)2.87936748
54substrate-dependent cell migration (GO:0006929)2.87353770
55positive regulation of blood vessel endothelial cell migration (GO:0043536)2.87134468
56positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.86832278
57collagen catabolic process (GO:0030574)2.86033196
58renal filtration (GO:0097205)2.84777870
59blood vessel remodeling (GO:0001974)2.84585117
60negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.84237928
61metanephric mesenchyme development (GO:0072075)2.82410199
62multicellular organismal macromolecule metabolic process (GO:0044259)2.81994730
63positive regulation of endothelial cell apoptotic process (GO:2000353)2.80477010
64mesenchymal-epithelial cell signaling (GO:0060638)2.79115805
65endothelial cell morphogenesis (GO:0001886)2.76684341
66regulation of integrin-mediated signaling pathway (GO:2001044)2.76268580
67regulation of endothelial cell differentiation (GO:0045601)2.75623570
68endocytic recycling (GO:0032456)2.74606150
69dermatan sulfate metabolic process (GO:0030205)2.74144702
70kidney mesenchyme development (GO:0072074)2.73473166
71positive regulation of macrophage cytokine production (GO:0060907)2.73360398
72fibril organization (GO:0097435)2.72017753
73actin filament depolymerization (GO:0030042)2.71479191
74negative regulation of smooth muscle cell migration (GO:0014912)2.71306125
75bone trabecula formation (GO:0060346)2.71303983
76atrioventricular valve morphogenesis (GO:0003181)2.69734048
77endocardial cushion development (GO:0003197)2.69692072
78cell migration involved in sprouting angiogenesis (GO:0002042)2.68532641
79vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.68098630
80regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.67911649
81desmosome organization (GO:0002934)2.66213161
82multicellular organismal catabolic process (GO:0044243)2.64317865
83cytoskeletal anchoring at plasma membrane (GO:0007016)2.63875271
84extracellular matrix disassembly (GO:0022617)2.63109884
85actin filament bundle assembly (GO:0051017)2.62943441
86actin filament bundle organization (GO:0061572)2.62943441
87semaphorin-plexin signaling pathway (GO:0071526)2.62443801
88multicellular organismal metabolic process (GO:0044236)2.61025819
89extracellular matrix assembly (GO:0085029)2.61013523
90ganglion development (GO:0061548)2.60921169
91dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.60375757
92cortical actin cytoskeleton organization (GO:0030866)2.59617911
93regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.57235217
94heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.56700686
95surfactant homeostasis (GO:0043129)2.56479463
96trabecula formation (GO:0060343)2.55800622
97synaptic vesicle docking involved in exocytosis (GO:0016081)2.55732308
98regulation of glucose import in response to insulin stimulus (GO:2001273)2.55048990
99protein localization to endosome (GO:0036010)2.54094614
100heart trabecula formation (GO:0060347)2.53891161
101epithelial cell-cell adhesion (GO:0090136)2.53707860
102patterning of blood vessels (GO:0001569)2.52115941
103positive regulation of osteoblast proliferation (GO:0033690)2.51771045
104artery development (GO:0060840)2.51583988
105cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.50037540
106regulation of tight junction assembly (GO:2000810)2.49920766
107atrial septum morphogenesis (GO:0060413)2.49399610
108chondrocyte development (GO:0002063)2.49352957
109muscle cell migration (GO:0014812)2.49239514
110extracellular matrix organization (GO:0030198)2.49164300
111peptidyl-proline hydroxylation (GO:0019511)2.48613246
112cellular response to vitamin (GO:0071295)2.48595136
113extracellular structure organization (GO:0043062)2.48540170
114cochlea morphogenesis (GO:0090103)2.48006872
115germ cell migration (GO:0008354)2.46050865
116positive regulation of receptor recycling (GO:0001921)2.45490838
117response to fluid shear stress (GO:0034405)2.45276513
118negative regulation of cardiac muscle tissue growth (GO:0055022)2.44512256
119negative regulation of heart growth (GO:0061117)2.44512256
120mesodermal cell differentiation (GO:0048333)2.44414534
121axon extension (GO:0048675)2.43951917
122positive regulation of endothelial cell differentiation (GO:0045603)2.42986810
123retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.42711528
124sprouting angiogenesis (GO:0002040)2.42646908
125protein localization to cell surface (GO:0034394)2.42083193
126skin morphogenesis (GO:0043589)2.41598145
127tooth mineralization (GO:0034505)2.40635840
128positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.40457983
129venous blood vessel morphogenesis (GO:0048845)2.39571435
130negative regulation of vascular permeability (GO:0043116)2.39368551
131Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.39223432
132insulin-like growth factor receptor signaling pathway (GO:0048009)2.39101014
133negative regulation of catenin import into nucleus (GO:0035414)2.38351546
134negative regulation of homotypic cell-cell adhesion (GO:0034111)2.38194626
135chondroitin sulfate biosynthetic process (GO:0030206)2.37410823
136wound healing, spreading of cells (GO:0044319)2.37273077
137glial cell migration (GO:0008347)2.36848756
138endothelial cell proliferation (GO:0001935)2.36716812
139regulation of NFAT protein import into nucleus (GO:0051532)2.36532156
140negative regulation of cartilage development (GO:0061037)2.36071616
141regulation of p38MAPK cascade (GO:1900744)2.35864409
142positive regulation of p38MAPK cascade (GO:1900745)2.35050717
143adherens junction assembly (GO:0034333)2.34895428
144blood vessel endothelial cell migration (GO:0043534)2.34880759
145dermatan sulfate biosynthetic process (GO:0030208)2.34731796
146positive regulation of axon extension (GO:0045773)2.33370066
147cell proliferation involved in metanephros development (GO:0072203)2.33364824
148positive regulation of epithelial to mesenchymal transition (GO:0010718)2.33225688
149regulation of vasculogenesis (GO:2001212)2.32958553
150cell-substrate junction assembly (GO:0007044)2.30339422

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human4.88321948
2RARG_19884340_ChIP-ChIP_MEFs_Mouse3.55432817
3* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.51384762
4CLOCK_20551151_ChIP-Seq_293T_Human2.92430120
5EGR1_19374776_ChIP-ChIP_THP-1_Human2.57096030
6TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.51636484
7EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.40354022
8TP63_17297297_ChIP-ChIP_HaCaT_Human2.33543187
9EP300_21415370_ChIP-Seq_HL-1_Mouse2.28590982
10ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.25775235
11RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.22471190
12GATA1_22025678_ChIP-Seq_K562_Human2.13805258
13HIF1A_21447827_ChIP-Seq_MCF-7_Human2.13409662
14CJUN_26792858_Chip-Seq_BT549_Human2.12717489
15LXR_22292898_ChIP-Seq_THP-1_Human2.10166902
16ELK3_25401928_ChIP-Seq_HUVEC_Human2.09042487
17GATA2_21666600_ChIP-Seq_HMVEC_Human2.06263997
18TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.03757839
19EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.01510239
20PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.01385347
21WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.01319237
22TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.00399462
23SMAD_19615063_ChIP-ChIP_OVARY_Human1.97664861
24WT1_19549856_ChIP-ChIP_CCG9911_Human1.93289218
25CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.90608392
26* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.89220216
27GATA1_19941826_ChIP-Seq_K562_Human1.87815604
28KDM2B_26808549_Chip-Seq_SUP-B15_Human1.82882713
29CDX2_19796622_ChIP-Seq_MESCs_Mouse1.77440602
30BRD4_25478319_ChIP-Seq_HGPS_Human1.76940714
31RBPJ_22232070_ChIP-Seq_NCS_Mouse1.75257081
32FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.67718622
33ZNF263_19887448_ChIP-Seq_K562_Human1.65712286
34ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.57342215
35MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.56713648
36TP53_16413492_ChIP-PET_HCT116_Human1.54246903
37* TBX20_22080862_ChIP-Seq_HEART_Mouse1.53471938
38* TBX20_22328084_ChIP-Seq_HEART_Mouse1.53471938
39KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.52888361
40* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.52023361
41P300_27058665_Chip-Seq_ZR-75-30cells_Human1.51502090
42KDM2B_26808549_Chip-Seq_K562_Human1.50994776
43STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.50921494
44TP53_22127205_ChIP-Seq_IMR90_Human1.50820236
45TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49944822
46KDM2B_26808549_Chip-Seq_DND41_Human1.49874217
47THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.49611927
48TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.48659870
49ESR2_21235772_ChIP-Seq_MCF-7_Human1.48224731
50SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.46448537
51SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.46448537
52EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.44836197
53ESR1_21235772_ChIP-Seq_MCF-7_Human1.43591241
54JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.40346157
55ZNF217_24962896_ChIP-Seq_MCF-7_Human1.39797349
56NFIB_24661679_ChIP-Seq_LUNG_Mouse1.37943028
57* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.35470588
58* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.35470588
59TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34301389
60* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.34194343
61ZFP281_27345836_Chip-Seq_ESCs_Mouse1.33456792
62TP53_23651856_ChIP-Seq_MEFs_Mouse1.32698814
63ERG_21242973_ChIP-ChIP_JURKAT_Human1.32457698
64SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.30864265
65UBF1/2_26484160_Chip-Seq_HMECs_Human1.29914964
66FOXO3_23340844_ChIP-Seq_DLD1_Human1.29850314
67JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.29499295
68TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.29261712
69FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.29208379
70DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.28886516
71SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.28489042
72ESR1_20079471_ChIP-ChIP_T-47D_Human1.27619036
73EZH2_18974828_ChIP-Seq_MESCs_Mouse1.27440881
74RNF2_18974828_ChIP-Seq_MESCs_Mouse1.27440881
75STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.27424103
76NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.27132295
77EED_16625203_ChIP-ChIP_MESCs_Mouse1.25569411
78* TET1_21490601_ChIP-Seq_MESCs_Mouse1.24960284
79FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.24599532
80KDM2B_26808549_Chip-Seq_JURKAT_Human1.23927919
81TP53_18474530_ChIP-ChIP_U2OS_Human1.22327199
82KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.22304880
83GATA2_19941826_ChIP-Seq_K562_Human1.22029112
84ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.21643892
85ATF3_27146783_Chip-Seq_COLON_Human1.19580824
86SMC3_22415368_ChIP-Seq_MEFs_Mouse1.19333878
87TCF4_18268006_ChIP-ChIP_LS174T_Human1.17845078
88NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.17464308
89TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.17158869
90* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17099095
91STAT6_21828071_ChIP-Seq_BEAS2B_Human1.16910784
92PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.16747945
93SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.15764013
94SALL4_18804426_ChIP-ChIP_XEN_Mouse1.15600063
95KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.15400312
96MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.14117756
97UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.12987664
98SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.12968735
99SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.12865708
100SOX9_24532713_ChIP-Seq_HFSC_Mouse1.10408074
101RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.10395148
102CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.10028819
103SMC1_22415368_ChIP-Seq_MEFs_Mouse1.10011844
104RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.09704265
105* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.09024328
106* ISL1_27105846_Chip-Seq_CPCs_Mouse1.08616122
107DNAJC2_21179169_ChIP-ChIP_NT2_Human1.07067676
108SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06678978
109CTCF_27219007_Chip-Seq_ERYTHROID_Human1.06489172
110SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.05935190
111* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.04743092
112RACK7_27058665_Chip-Seq_MCF-7_Human1.04592463
113SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.04418898
114KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.04237229
115JARID2_20075857_ChIP-Seq_MESCs_Mouse1.03946307
116P63_26484246_Chip-Seq_KERATINOCYTES_Human1.03731439
117TCF7_22412390_ChIP-Seq_EML_Mouse1.03658948
118VDR_21846776_ChIP-Seq_THP-1_Human1.03398101
119TET1_21451524_ChIP-Seq_MESCs_Mouse1.03204155
120SOX2_20726797_ChIP-Seq_SW620_Human1.02467075
121GATA1_19941827_ChIP-Seq_MEL_Mouse1.00733906
122SA1_22415368_ChIP-Seq_MEFs_Mouse0.98552895
123MTF2_20144788_ChIP-Seq_MESCs_Mouse0.98502513
124* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.98297151
125SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.97925885
126ZFP281_18757296_ChIP-ChIP_E14_Mouse0.97108248
127BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.96469731
128SMC4_20622854_ChIP-Seq_HELA_Human0.95499728
129TP53_20018659_ChIP-ChIP_R1E_Mouse0.95147858
130HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.94930074
131SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.94867788
132PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.94205188
133SA1_27219007_Chip-Seq_ERYTHROID_Human0.94036139
134* NR3C1_23031785_ChIP-Seq_PC12_Mouse0.93353679
135RNF2_27304074_Chip-Seq_ESCs_Mouse0.92540430

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.11013271
2MP0005275_abnormal_skin_tensile4.03819242
3MP0005503_abnormal_tendon_morphology3.98384485
4MP0006054_spinal_hemorrhage3.69317167
5MP0001958_emphysema3.46041953
6MP0003279_aneurysm3.40629422
7MP0003705_abnormal_hypodermis_morpholog3.34484887
8MP0004272_abnormal_basement_membrane3.28942233
9MP0010368_abnormal_lymphatic_system3.15100011
10MP0005623_abnormal_meninges_morphology2.61411589
11MP0001879_abnormal_lymphatic_vessel2.51889090
12MP0004084_abnormal_cardiac_muscle2.14249991
13MP0003566_abnormal_cell_adhesion2.11569649
14MP0009384_cardiac_valve_regurgitation1.98204267
15MP0000767_abnormal_smooth_muscle1.87377615
16MP0000751_myopathy1.82663858
17MP0003091_abnormal_cell_migration1.74549135
18MP0005409_darkened_coat_color1.69585431
19MP0008775_abnormal_heart_ventricle1.69030223
20MP0002295_abnormal_pulmonary_circulatio1.61412807
21MP0006138_congestive_heart_failure1.60740862
22MP0010352_gastrointestinal_tract_polyps1.59299174
23MP0003828_pulmonary_edema1.58348075
24MP0004147_increased_porphyrin_level1.56447092
25MP0000733_abnormal_muscle_development1.53439874
26MP0005167_abnormal_blood-brain_barrier1.51833870
27MP0005508_abnormal_skeleton_morphology1.49102092
28MP0005058_abnormal_lysosome_morphology1.47510919
29MP0003656_abnormal_erythrocyte_physiolo1.43522034
30MP0005076_abnormal_cell_differentiation1.38969147
31MP0002108_abnormal_muscle_morphology1.37664495
32MP0001348_abnormal_lacrimal_gland1.35598867
33MP0001849_ear_inflammation1.33082436
34MP0004215_abnormal_myocardial_fiber1.30881076
35MP0003045_fibrosis1.29629794
36MP0004233_abnormal_muscle_weight1.28701552
37MP0000343_altered_response_to1.27529048
38MP0003724_increased_susceptibility_to1.26970057
39MP0000534_abnormal_ureter_morphology1.26742627
40MP0005023_abnormal_wound_healing1.22360573
41MP0003300_gastrointestinal_ulcer1.22013668
42MP0001544_abnormal_cardiovascular_syste1.22008830
43MP0005385_cardiovascular_system_phenoty1.22008830
44MP0002877_abnormal_melanocyte_morpholog1.22002369
45MP0010630_abnormal_cardiac_muscle1.21102997
46MP0002128_abnormal_blood_circulation1.20202856
47MP0002925_abnormal_cardiovascular_devel1.16039179
48MP0002060_abnormal_skin_morphology1.15898384
49MP0000762_abnormal_tongue_morphology1.14972087
50MP0000749_muscle_degeneration1.14723799
51MP0000750_abnormal_muscle_regeneration1.14490381
52MP0005164_abnormal_response_to1.14196678
53MP0004087_abnormal_muscle_fiber1.13657459
54MP0009278_abnormal_bone_marrow1.11945855
55MP0004510_myositis1.11851718
56MP0003453_abnormal_keratinocyte_physiol1.10823569
57MP0003941_abnormal_skin_development1.10713960
58MP0004036_abnormal_muscle_relaxation1.10155612
59MP0002972_abnormal_cardiac_muscle1.09938313
60MP0003385_abnormal_body_wall1.09163037
61MP0004484_altered_response_of1.09092022
62MP0005397_hematopoietic_system_phenotyp1.08428880
63MP0001545_abnormal_hematopoietic_system1.08428880
64MP0004883_abnormal_blood_vessel1.08045382
65MP0001614_abnormal_blood_vessel1.07712416
66MP0005595_abnormal_vascular_smooth1.06998483
67MP0003567_abnormal_fetal_cardiomyocyte1.06596485
68MP0005257_abnormal_intraocular_pressure1.06192607
69MP0005330_cardiomyopathy1.04897991
70MP0003115_abnormal_respiratory_system1.04222372
71MP0003950_abnormal_plasma_membrane1.04196078
72MP0003942_abnormal_urinary_system1.02789064
73MP0009053_abnormal_anal_canal1.02668834
74MP0002896_abnormal_bone_mineralization1.01166566
75MP0005388_respiratory_system_phenotype0.99099625
76MP0002133_abnormal_respiratory_system0.99099625
77MP0009250_abnormal_appendicular_skeleto0.97521248
78MP0000266_abnormal_heart_morphology0.96806260
79MP0004858_abnormal_nervous_system0.96650579
80MP0001542_abnormal_bone_strength0.95888256
81MP0005375_adipose_tissue_phenotype0.94189137
82MP0000747_muscle_weakness0.94136494
83MP0009840_abnormal_foam_cell0.94073666
84MP0001915_intracranial_hemorrhage0.93478618
85MP0003191_abnormal_cellular_cholesterol0.92672718
86MP0002998_abnormal_bone_remodeling0.91968533
87MP0001175_abnormal_lung_morphology0.91697953
88MP0005620_abnormal_muscle_contractility0.90242889
89MP0005451_abnormal_body_composition0.90017819
90MP0005390_skeleton_phenotype0.88535047
91MP0001299_abnormal_eye_distance/0.88387674
92MP0000759_abnormal_skeletal_muscle0.88328962
93MP0000015_abnormal_ear_pigmentation0.87452543
94MP0000013_abnormal_adipose_tissue0.86975167
95MP0003122_maternal_imprinting0.86656747
96MP0005197_abnormal_uvea_morphology0.84657805
97MP0004185_abnormal_adipocyte_glucose0.84415227
98MP0001243_abnormal_dermal_layer0.84322430
99MP0000462_abnormal_digestive_system0.84321337
100MP0003329_amyloid_beta_deposits0.84086425
101MP0002168_other_aberrant_phenotype0.83253964
102MP0009780_abnormal_chondrocyte_physiolo0.82574536
103MP0004130_abnormal_muscle_cell0.81442451
104MP0000428_abnormal_craniofacial_morphol0.80831060
105MP0002166_altered_tumor_susceptibility0.80242271
106MP0002269_muscular_atrophy0.79339448
107MP0004808_abnormal_hematopoietic_stem0.78099806
108MP0000537_abnormal_urethra_morphology0.77601315
109MP0005369_muscle_phenotype0.77583689
110MP0003303_peritoneal_inflammation0.76665764
111MP0000249_abnormal_blood_vessel0.76045465
112MP0001533_abnormal_skeleton_physiology0.75430279
113MP0000163_abnormal_cartilage_morphology0.73817063
114MP0004859_abnormal_synaptic_plasticity0.73393852
115MP0010030_abnormal_orbit_morphology0.73224977
116MP0002796_impaired_skin_barrier0.72625954
117MP0003448_altered_tumor_morphology0.72372551
118MP0005171_absent_coat_pigmentation0.72115727
119MP0002089_abnormal_postnatal_growth/wei0.71807059
120MP0000003_abnormal_adipose_tissue0.70762340
121MP0008260_abnormal_autophagy0.69804334
122MP0010386_abnormal_urinary_bladder0.69677033
123MP0002249_abnormal_larynx_morphology0.69526323
124MP0005165_increased_susceptibility_to0.69339252
125MP0003935_abnormal_craniofacial_develop0.69223878
126MP0005666_abnormal_adipose_tissue0.68842086
127MP0002106_abnormal_muscle_physiology0.68506689
128MP0002113_abnormal_skeleton_development0.68121056
129MP0005501_abnormal_skin_physiology0.67597257
130MP0005193_abnormal_anterior_eye0.66661580
131MP0000467_abnormal_esophagus_morphology0.64692236
132MP0003634_abnormal_glial_cell0.63624741
133MP0005621_abnormal_cell_physiology0.62559472
134MP0000432_abnormal_head_morphology0.62377797

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)6.46284960
2Premature rupture of membranes (HP:0001788)5.63269545
3Ankle contracture (HP:0006466)4.70071182
4Aortic aneurysm (HP:0004942)4.54905822
5Broad metatarsal (HP:0001783)4.53639675
6Cerebral aneurysm (HP:0004944)4.51765407
7Aortic dissection (HP:0002647)4.31147866
8Shallow orbits (HP:0000586)4.27062646
9Bladder diverticulum (HP:0000015)3.66425237
10Dilatation of the ascending aorta (HP:0005111)3.51010564
11Atrophic scars (HP:0001075)3.44063780
12Soft skin (HP:0000977)3.34420161
13Increased connective tissue (HP:0009025)3.30098303
14Mitral valve prolapse (HP:0001634)3.20803368
15Wrist flexion contracture (HP:0001239)3.16394493
16Vascular tortuosity (HP:0004948)3.14041990
17Spinal rigidity (HP:0003306)3.13600994
18Follicular hyperkeratosis (HP:0007502)3.11551645
19Fragile skin (HP:0001030)3.08156282
20Type 1 muscle fiber predominance (HP:0003803)3.05910677
21Polycythemia (HP:0001901)2.96583956
22Hyperacusis (HP:0010780)2.85315819
23Hematochezia (HP:0002573)2.83954834
24Cervical subluxation (HP:0003308)2.79598847
25Arterial tortuosity (HP:0005116)2.77413775
26Wormian bones (HP:0002645)2.76444020
27Vertebral compression fractures (HP:0002953)2.72523069
28Aneurysm (HP:0002617)2.69837930
29Ulnar bowing (HP:0003031)2.67595328
30Peritonitis (HP:0002586)2.66412793
31Mildly elevated creatine phosphokinase (HP:0008180)2.64708328
32Genu recurvatum (HP:0002816)2.63037875
33Increased variability in muscle fiber diameter (HP:0003557)2.62197022
34Striae distensae (HP:0001065)2.59184550
35Enlarged penis (HP:0000040)2.58689017
36Osteolytic defects of the phalanges of the hand (HP:0009771)2.54544164
37Osteolytic defects of the hand bones (HP:0009699)2.54544164
38Bowel diverticulosis (HP:0005222)2.51396830
39Subacute progressive viral hepatitis (HP:0006572)2.48998003
40Overgrowth (HP:0001548)2.45439008
41Pulmonary artery stenosis (HP:0004415)2.41759872
42Joint laxity (HP:0001388)2.38553292
43Aortic regurgitation (HP:0001659)2.34732321
44Insomnia (HP:0100785)2.34612194
45Neonatal short-limb short stature (HP:0008921)2.33831530
46Abnormality of dentin (HP:0010299)2.32670682
47Short 4th metacarpal (HP:0010044)2.29902031
48Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.29902031
49Hyperextensible skin (HP:0000974)2.27546235
50Achilles tendon contracture (HP:0001771)2.25748789
51Mitral regurgitation (HP:0001653)2.25383248
52Camptodactyly of toe (HP:0001836)2.25223666
53Slender build (HP:0001533)2.24775681
54Abnormality of skeletal muscle fiber size (HP:0012084)2.22518903
55Blue sclerae (HP:0000592)2.22022640
56Distal lower limb amyotrophy (HP:0008944)2.17237365
57Hypoplasia of the iris (HP:0007676)2.14218383
58Difficulty climbing stairs (HP:0003551)2.13760056
59Obstructive sleep apnea (HP:0002870)2.12304793
60Hypoventilation (HP:0002791)2.10562072
61Venous abnormality (HP:0002624)2.08360649
62Thin bony cortex (HP:0002753)2.07000582
63Muscle fiber splitting (HP:0003555)2.06898723
64Scapular winging (HP:0003691)2.03295022
65Broad ribs (HP:0000885)2.03143181
66Joint stiffness (HP:0001387)2.01088700
67Spondylolisthesis (HP:0003302)1.98419703
68Distal lower limb muscle weakness (HP:0009053)1.98363286
69Natal tooth (HP:0000695)1.98123699
70Aortic valve stenosis (HP:0001650)1.98112500
71Deviation of the hallux (HP:0010051)1.97113318
72Broad face (HP:0000283)1.96722437
73Mitral stenosis (HP:0001718)1.96103149
74Turricephaly (HP:0000262)1.94063724
75Disproportionate tall stature (HP:0001519)1.92654054
76Venous insufficiency (HP:0005293)1.92653864
77Generalized amyotrophy (HP:0003700)1.91999191
78Renal duplication (HP:0000075)1.91845982
79Coronal craniosynostosis (HP:0004440)1.91363047
80Upper limb amyotrophy (HP:0009129)1.91168508
81Distal upper limb amyotrophy (HP:0007149)1.91168508
82Elbow flexion contracture (HP:0002987)1.90609069
83Biconcave vertebral bodies (HP:0004586)1.89645659
84Hallux valgus (HP:0001822)1.89164001
85Mild short stature (HP:0003502)1.88936234
86Abnormality of the Achilles tendon (HP:0005109)1.88463611
87Abnormality of the acetabulum (HP:0003170)1.86946254
88Rectal prolapse (HP:0002035)1.86064863
89Lower limb amyotrophy (HP:0007210)1.85016136
90Long toe (HP:0010511)1.83994722
91Round ear (HP:0100830)1.83984151
92Lymphangioma (HP:0100764)1.83190913
93Hypercortisolism (HP:0001578)1.82666321
94Broad palm (HP:0001169)1.82398992
95Asymmetry of the thorax (HP:0001555)1.82144268
96Sudden death (HP:0001699)1.80014290
97Bicuspid aortic valve (HP:0001647)1.79132985
98Ulnar deviation of the wrist (HP:0003049)1.78104379
99Abnormality of the 4th metacarpal (HP:0010012)1.77871933
100Lipoatrophy (HP:0100578)1.77837943
101Hyporeflexia of lower limbs (HP:0002600)1.75982328
102Short nail (HP:0001799)1.75297257
103Abnormality of the heme biosynthetic pathway (HP:0010472)1.74858388
104Buphthalmos (HP:0000557)1.74646345
105Flexion contracture of toe (HP:0005830)1.74446265
106Joint contractures involving the joints of the feet (HP:0100492)1.74446265
107Spontaneous hematomas (HP:0007420)1.72915552
108Syringomyelia (HP:0003396)1.72804445
109Spinal cord lesions (HP:0100561)1.72804445
110Abnormality of the peritoneum (HP:0002585)1.72644435
111Asymmetric septal hypertrophy (HP:0001670)1.72476789
112Increased density of long bones (HP:0006392)1.71163981
113Ectopia lentis (HP:0001083)1.70848552
114Abnormality of the calf musculature (HP:0001430)1.69648521
115Flat cornea (HP:0007720)1.69234596
116Limb-girdle muscle weakness (HP:0003325)1.68292997
117Breech presentation (HP:0001623)1.68104989
118Hand muscle atrophy (HP:0009130)1.67401216
119Mesangial abnormality (HP:0001966)1.66798509
120Nonimmune hydrops fetalis (HP:0001790)1.66302662
121Elfin facies (HP:0004428)1.66243222
122Abnormality of the phalanges of the hallux (HP:0010057)1.66206684
123Osteopenia (HP:0000938)1.65809116
124Knee flexion contracture (HP:0006380)1.65329261
125Wide anterior fontanel (HP:0000260)1.65162635
126Overriding aorta (HP:0002623)1.63969511
127Bowed forearm bones (HP:0003956)1.63739420
128Bowing of the arm (HP:0006488)1.63739420
129Radial bowing (HP:0002986)1.62870351
130Renovascular hypertension (HP:0100817)1.62292930
131Reduced subcutaneous adipose tissue (HP:0003758)1.62167865
132Atrial fibrillation (HP:0005110)1.61973040
133Thin ribs (HP:0000883)1.61827142
134Protruding ear (HP:0000411)1.60883741
135Osteoarthritis (HP:0002758)1.60000532
136Hip contracture (HP:0003273)1.59068291
137Abnormal delivery (HP:0001787)1.58942294

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE15.65222373
2TRIB34.14037365
3TTN3.31189545
4PDGFRA3.06444219
5RIPK13.05485224
6TGFBR22.95903832
7PKN22.63931674
8DDR22.62402912
9PRPF4B2.43667777
10ICK2.34390032
11DMPK2.16841052
12LATS11.95520343
13CAMK1D1.84788513
14LATS21.80209156
15ERN11.80101072
16FER1.78644682
17BMX1.75111515
18PTK2B1.73230377
19MST1R1.53824724
20PAK21.52913035
21EPHB21.51410717
22KDR1.49718141
23IRAK31.44823939
24TGFBR11.42478458
25MYLK1.40960875
26LRRK21.39147469
27EEF2K1.38318299
28STK31.37758539
29PTK61.37646581
30TRPM71.33781034
31ARAF1.33345819
32EPHA31.31413227
33PTK21.31051113
34CAMK1G1.30760473
35PDGFRB1.29758108
36EPHA21.28562383
37SMG11.21574557
38STK381.18389009
39MAP3K61.14611612
40ERBB41.11901834
41RET1.10963719
42PAK41.08779064
43TAOK21.07668840
44AKT31.06420366
45NTRK11.05768730
46ILK1.01977445
47STK241.00239772
48SIK10.97291488
49PAK30.92069602
50MAP2K10.91099650
51CDK120.87014161
52PRKD10.86464719
53RPS6KA40.86027298
54MTOR0.85100971
55ROCK10.85048442
56SCYL20.84469663
57TESK10.84211157
58ZAK0.81222830
59CDK60.80391403
60MAPK70.80130419
61STK100.79651598
62PRKCH0.79165264
63LMTK20.77599548
64KSR20.75984796
65ERBB30.74832935
66NME20.74378717
67PRKD30.74117494
68JAK10.73426198
69PIM20.72976672
70PRKD20.67640172
71EPHB10.66003049
72MOS0.65299578
73PDPK10.64860633
74CAMKK20.64207649
75BRAF0.63746581
76LIMK10.62084125
77JAK30.60787103
78MAP3K130.60293680
79MET0.59783252
80FGFR10.59277725
81PAK60.58791611
82CAMKK10.58701013
83NEK90.57974545
84MAP3K100.56726288
85CAMK2G0.55270356
86GSK3A0.54821234
87MARK20.54212524
88TBK10.53136599
89MELK0.52445324
90MAP2K30.52369810
91NEK10.50856441
92PIK3CA0.50829559
93MAP3K20.50784906
94WNK10.50776141
95INSR0.50628263
96FGFR30.50574581
97RPS6KL10.50460877
98RPS6KC10.50460877
99MAPK110.49655163
100RAF10.48243012
101TYRO30.47639265
102TAOK10.47550609
103CAMK2B0.43609593
104FLT30.43185480
105CDC42BPA0.42311143
106PDK20.42228877
107SRC0.42162991
108EGFR0.42088591
109MAP3K80.41841057
110MAPK120.40939391
111FGFR40.40772597
112KSR10.40395366
113PLK20.39090013
114SGK30.38844542
115AKT20.38132747
116CDK11A0.37800408
117DYRK1B0.37267961
118PRKG20.37238821
119CAMK40.36800721
120PAK10.36537709
121CDK150.36247859
122KIT0.36042968
123PHKG10.35877295
124PHKG20.35877295
125CHUK0.35745152
126ABL20.35369604
127RPS6KA20.34274920
128DAPK30.33909415
129ROCK20.33620144
130MAP3K30.33456613
131MAP3K70.33455745
132STK40.32346981
133MAPK40.32247975
134JAK20.32207405
135DAPK20.31762857
136MAP3K10.30229918
137CDK180.30122074
138MARK10.28965236

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045122.83757952
2Focal adhesion_Homo sapiens_hsa045102.31104406
3AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.05159489
4Dilated cardiomyopathy_Homo sapiens_hsa054142.02632843
5Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.93254843
6Adherens junction_Homo sapiens_hsa045201.84964887
7Amoebiasis_Homo sapiens_hsa051461.81320637
8Proteoglycans in cancer_Homo sapiens_hsa052051.74061563
9Small cell lung cancer_Homo sapiens_hsa052221.64510348
10Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.62607947
11Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.58162397
12Malaria_Homo sapiens_hsa051441.57209615
13Glycosaminoglycan degradation_Homo sapiens_hsa005311.54514865
14TGF-beta signaling pathway_Homo sapiens_hsa043501.51964591
15Chronic myeloid leukemia_Homo sapiens_hsa052201.49981623
16Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.47484713
17Prion diseases_Homo sapiens_hsa050201.46504254
18Platelet activation_Homo sapiens_hsa046111.37264370
19Viral myocarditis_Homo sapiens_hsa054161.34435646
20Toxoplasmosis_Homo sapiens_hsa051451.33465168
21Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.32774492
22Other glycan degradation_Homo sapiens_hsa005111.28015595
23Pancreatic cancer_Homo sapiens_hsa052121.24685357
24Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.24515056
25MicroRNAs in cancer_Homo sapiens_hsa052061.19904789
26Glioma_Homo sapiens_hsa052141.19717733
27Protein digestion and absorption_Homo sapiens_hsa049741.19422127
28Leukocyte transendothelial migration_Homo sapiens_hsa046701.16994321
29PI3K-Akt signaling pathway_Homo sapiens_hsa041511.16367535
30Hippo signaling pathway_Homo sapiens_hsa043901.15298944
31Dorso-ventral axis formation_Homo sapiens_hsa043201.13422415
32Rap1 signaling pathway_Homo sapiens_hsa040151.09597664
33Renin secretion_Homo sapiens_hsa049241.08958293
34Regulation of actin cytoskeleton_Homo sapiens_hsa048101.08792583
35Bladder cancer_Homo sapiens_hsa052191.08021157
36VEGF signaling pathway_Homo sapiens_hsa043701.07492074
37ErbB signaling pathway_Homo sapiens_hsa040121.05952588
38Colorectal cancer_Homo sapiens_hsa052101.05646806
39cGMP-PKG signaling pathway_Homo sapiens_hsa040221.04913322
40Renal cell carcinoma_Homo sapiens_hsa052111.04673188
41HIF-1 signaling pathway_Homo sapiens_hsa040661.03223074
42Gap junction_Homo sapiens_hsa045401.02442432
43Salmonella infection_Homo sapiens_hsa051321.02348085
44Estrogen signaling pathway_Homo sapiens_hsa049151.02162824
45Vascular smooth muscle contraction_Homo sapiens_hsa042701.01272634
46TNF signaling pathway_Homo sapiens_hsa046681.00966689
47Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.99013099
48Osteoclast differentiation_Homo sapiens_hsa043800.98848759
49Leishmaniasis_Homo sapiens_hsa051400.98252070
50Melanoma_Homo sapiens_hsa052180.97412250
51Pathways in cancer_Homo sapiens_hsa052000.96583724
52Aldosterone synthesis and secretion_Homo sapiens_hsa049250.96345710
53Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.95983825
54Endometrial cancer_Homo sapiens_hsa052130.95375174
55Long-term potentiation_Homo sapiens_hsa047200.94598568
56Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.94591258
57Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.94423772
58Neurotrophin signaling pathway_Homo sapiens_hsa047220.93325076
59Axon guidance_Homo sapiens_hsa043600.91768070
60Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.91719241
61mTOR signaling pathway_Homo sapiens_hsa041500.90659899
62Ovarian steroidogenesis_Homo sapiens_hsa049130.89478998
63Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.88388659
64Central carbon metabolism in cancer_Homo sapiens_hsa052300.88112054
65Thyroid hormone signaling pathway_Homo sapiens_hsa049190.86757370
66Prostate cancer_Homo sapiens_hsa052150.86412031
67* Endocytosis_Homo sapiens_hsa041440.85736662
68Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.85236490
69* Phospholipase D signaling pathway_Homo sapiens_hsa040720.84675237
70Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.83606411
71Hepatitis B_Homo sapiens_hsa051610.83389683
72Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.83184441
73Apoptosis_Homo sapiens_hsa042100.83157880
74Tight junction_Homo sapiens_hsa045300.83063474
75Oxytocin signaling pathway_Homo sapiens_hsa049210.83047487
76Shigellosis_Homo sapiens_hsa051310.82966087
77GnRH signaling pathway_Homo sapiens_hsa049120.82354960
78Notch signaling pathway_Homo sapiens_hsa043300.81830851
79HTLV-I infection_Homo sapiens_hsa051660.81182790
80Longevity regulating pathway - mammal_Homo sapiens_hsa042110.79663849
81Phosphatidylinositol signaling system_Homo sapiens_hsa040700.78790561
82Adipocytokine signaling pathway_Homo sapiens_hsa049200.77354162
83Tuberculosis_Homo sapiens_hsa051520.76101144
84Insulin resistance_Homo sapiens_hsa049310.75698671
85Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.74532308
86Inositol phosphate metabolism_Homo sapiens_hsa005620.74400888
87Melanogenesis_Homo sapiens_hsa049160.73792803
88Vibrio cholerae infection_Homo sapiens_hsa051100.73363698
89Phagosome_Homo sapiens_hsa041450.72263735
90Pertussis_Homo sapiens_hsa051330.72118134
91Salivary secretion_Homo sapiens_hsa049700.70969815
92Basal cell carcinoma_Homo sapiens_hsa052170.70965887
93Ras signaling pathway_Homo sapiens_hsa040140.70810575
94Lysosome_Homo sapiens_hsa041420.69330068
95cAMP signaling pathway_Homo sapiens_hsa040240.68471111
96Acute myeloid leukemia_Homo sapiens_hsa052210.66968438
97Sphingolipid signaling pathway_Homo sapiens_hsa040710.65189760
98FoxO signaling pathway_Homo sapiens_hsa040680.64864065
99Toll-like receptor signaling pathway_Homo sapiens_hsa046200.64201906
100Rheumatoid arthritis_Homo sapiens_hsa053230.64059506
101MAPK signaling pathway_Homo sapiens_hsa040100.64025076
102Non-small cell lung cancer_Homo sapiens_hsa052230.64023253
103Gastric acid secretion_Homo sapiens_hsa049710.63821054
104Viral carcinogenesis_Homo sapiens_hsa052030.63339909
105Choline metabolism in cancer_Homo sapiens_hsa052310.62234433
106Wnt signaling pathway_Homo sapiens_hsa043100.61746480
107Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.59689365
108Thyroid cancer_Homo sapiens_hsa052160.59421371
109AMPK signaling pathway_Homo sapiens_hsa041520.58451826
110Insulin signaling pathway_Homo sapiens_hsa049100.58177081
111Hedgehog signaling pathway_Homo sapiens_hsa043400.57307935
112Prolactin signaling pathway_Homo sapiens_hsa049170.56022016
113Synaptic vesicle cycle_Homo sapiens_hsa047210.52886244
114Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.52502447
115Thyroid hormone synthesis_Homo sapiens_hsa049180.51084297
116Glucagon signaling pathway_Homo sapiens_hsa049220.49881428
117Cholinergic synapse_Homo sapiens_hsa047250.48935557

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