CYTIP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene contains 2 leucine zipper domains and a putative C-terminal nuclear targeting signal, but does not have any hydrophobic regions. This protein is expressed weakly in resting NK and T cells. The encoded protein modulates the activation of ARF genes by CYTH1. This protein interacts with CYTH1 and SNX27 proteins and may act to sequester CYTH1 protein in the cytoplasm. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous antigen (GO:0019883)6.05099273
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.87627640
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.87627640
4positive regulation of gamma-delta T cell activation (GO:0046645)5.82273639
5negative thymic T cell selection (GO:0045060)5.74568445
6negative T cell selection (GO:0043383)5.70995145
7positive regulation of interleukin-2 biosynthetic process (GO:0045086)5.14442811
8negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.01755810
9negative regulation of cell killing (GO:0031342)5.01755810
10positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.86467207
11antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.69287516
12regulation of interleukin-12 biosynthetic process (GO:0045075)4.67357727
13NIK/NF-kappaB signaling (GO:0038061)4.65040484
14thymic T cell selection (GO:0045061)4.60493128
15regulation of T cell tolerance induction (GO:0002664)4.55360770
16regulation of gamma-delta T cell differentiation (GO:0045586)4.54865349
17positive thymic T cell selection (GO:0045059)4.53831049
18T cell selection (GO:0045058)4.44278976
19interferon-gamma production (GO:0032609)4.40431243
20positive regulation of interleukin-2 production (GO:0032743)4.34019225
21response to interleukin-15 (GO:0070672)4.32285058
22regulation of gamma-delta T cell activation (GO:0046643)4.30590451
23regulation of alpha-beta T cell proliferation (GO:0046640)4.21876791
24growth hormone receptor signaling pathway (GO:0060396)4.17510341
25cellular response to interleukin-15 (GO:0071350)4.16852635
26myeloid dendritic cell differentiation (GO:0043011)4.08105302
27positive regulation of alpha-beta T cell proliferation (GO:0046641)4.07130427
28myeloid dendritic cell activation (GO:0001773)4.06529361
29T cell migration (GO:0072678)4.04632272
30negative regulation of T cell mediated immunity (GO:0002710)4.00833730
31modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.99891245
32positive regulation by organism of defense response of other organism involved in symbiotic interact3.99891245
33modulation by symbiont of host immune response (GO:0052553)3.99891245
34positive regulation by symbiont of host defense response (GO:0052509)3.99891245
35modulation by symbiont of host defense response (GO:0052031)3.99891245
36modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.99891245
37regulation of B cell receptor signaling pathway (GO:0050855)3.98725709
38JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.97273647
39positive T cell selection (GO:0043368)3.90162904
40negative regulation of interleukin-12 production (GO:0032695)3.87597052
41regulation of interleukin-2 biosynthetic process (GO:0045076)3.86640383
42T cell costimulation (GO:0031295)3.82294051
43leukocyte aggregation (GO:0070486)3.81855668
44lymphocyte costimulation (GO:0031294)3.76874934
45activated T cell proliferation (GO:0050798)3.76481484
46tolerance induction (GO:0002507)3.72472870
47negative regulation of lymphocyte mediated immunity (GO:0002707)3.71879741
48positive regulation of antigen processing and presentation (GO:0002579)3.70136272
49positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.70111928
50regulation of dendritic cell antigen processing and presentation (GO:0002604)3.60835637
51positive regulation of humoral immune response (GO:0002922)3.59149888
52regulation of B cell differentiation (GO:0045577)3.58633586
53cellular response to growth hormone stimulus (GO:0071378)3.57445047
54regulation of T cell mediated cytotoxicity (GO:0001914)3.57422429
55regulation of tolerance induction (GO:0002643)3.56001187
56cellular extravasation (GO:0045123)3.55702671
57regulation of hypersensitivity (GO:0002883)3.55308769
58regulation of T-helper 1 cell differentiation (GO:0045625)3.52971872
59regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.49179948
60positive regulation of B cell differentiation (GO:0045579)3.47498031
61positive regulation of interleukin-12 production (GO:0032735)3.46063329
62interferon-gamma-mediated signaling pathway (GO:0060333)3.45945999
63neutrophil activation involved in immune response (GO:0002283)3.44541996
64positive regulation of T cell mediated cytotoxicity (GO:0001916)3.44117989
65regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.43890019
66regulation of T cell receptor signaling pathway (GO:0050856)3.42418113
67positive regulation of isotype switching (GO:0045830)3.41473954
68detection of other organism (GO:0098543)3.40700880
69natural killer cell activation (GO:0030101)3.36761733
70cellular response to zinc ion (GO:0071294)3.35226948
71negative regulation of leukocyte mediated immunity (GO:0002704)3.33132819
72macrophage activation involved in immune response (GO:0002281)3.33031505
73response to type I interferon (GO:0034340)3.32216095
74positive regulation of natural killer cell differentiation (GO:0032825)3.32043505
75positive regulation of granulocyte differentiation (GO:0030854)3.31808410
76B cell receptor signaling pathway (GO:0050853)3.31478477
77T cell receptor signaling pathway (GO:0050852)3.31368942
78type I interferon signaling pathway (GO:0060337)3.30399692
79cellular response to type I interferon (GO:0071357)3.30399692
80regulation of isotype switching to IgG isotypes (GO:0048302)3.28739401
81neutrophil activation (GO:0042119)3.28038694
82regulation of antigen processing and presentation (GO:0002577)3.27445270
83Arp2/3 complex-mediated actin nucleation (GO:0034314)3.26082980
84T-helper cell differentiation (GO:0042093)3.26042419
85CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.26042419
86positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.25667431
87regulation of leukocyte mediated cytotoxicity (GO:0001910)3.24173093
88immunoglobulin mediated immune response (GO:0016064)3.24014027
89antigen receptor-mediated signaling pathway (GO:0050851)3.22933265
90positive regulation of tolerance induction (GO:0002645)3.22750274
91detection of bacterium (GO:0016045)3.22574799
92response to muramyl dipeptide (GO:0032495)3.20748189
93regulation of regulatory T cell differentiation (GO:0045589)3.19824808
94dendritic cell differentiation (GO:0097028)3.19225481
95positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.16269590
96regulation of interleukin-2 production (GO:0032663)3.15891560
97regulation of interferon-beta biosynthetic process (GO:0045357)3.14416787
98regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)3.12438095
99positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.11900861
100cytidine deamination (GO:0009972)3.10863880
101cytidine metabolic process (GO:0046087)3.10863880
102cytidine catabolic process (GO:0006216)3.10863880
103myeloid cell activation involved in immune response (GO:0002275)3.10433748
104antigen processing and presentation via MHC class Ib (GO:0002475)3.10411616
105response to peptidoglycan (GO:0032494)3.09932374
106regulation of interleukin-12 production (GO:0032655)3.08820021
107regulation of natural killer cell mediated immunity (GO:0002715)3.08196004
108regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.08196004
109lymphocyte migration (GO:0072676)3.07236301
110granulocyte activation (GO:0036230)3.07103004
111regulation of cell killing (GO:0031341)3.05431670
112positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.02821351
113positive regulation of DNA recombination (GO:0045911)3.00739379
114production of molecular mediator involved in inflammatory response (GO:0002532)3.00737275
115regulation of T-helper cell differentiation (GO:0045622)3.00012460
116negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.99899155
117respiratory burst (GO:0045730)2.99323300
118natural killer cell differentiation (GO:0001779)2.99211367
119positive regulation of natural killer cell mediated immunity (GO:0002717)2.98972117
120positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.98972117
121regulation of alpha-beta T cell activation (GO:0046634)2.98724878
122positive regulation of T-helper cell differentiation (GO:0045624)2.98144463
123pyrimidine ribonucleoside catabolic process (GO:0046133)2.98139507
124mature B cell differentiation (GO:0002335)2.97374606
125alpha-beta T cell activation (GO:0046631)2.97266734
126positive regulation of T cell cytokine production (GO:0002726)2.97189913
127T cell proliferation (GO:0042098)2.96127641
128regulation of response to interferon-gamma (GO:0060330)2.95292652
129regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.95180777
130T cell activation involved in immune response (GO:0002286)2.94133566
131defense response to protozoan (GO:0042832)2.93587808
132positive regulation of cell killing (GO:0031343)2.93434847
133mast cell activation (GO:0045576)2.93278039
134leukocyte degranulation (GO:0043299)2.93025643
135detection of external biotic stimulus (GO:0098581)2.93004398
136B cell mediated immunity (GO:0019724)2.92101771
137detection of molecule of bacterial origin (GO:0032490)2.91997564
138positive regulation of B cell mediated immunity (GO:0002714)2.91382098

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse7.11094551
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.95915363
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.38317640
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.57091330
5IRF8_21731497_ChIP-ChIP_J774_Mouse4.46689655
6STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.84933472
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.83786291
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.51117728
9STAT4_19710469_ChIP-ChIP_TH1__Mouse3.38155331
10BP1_19119308_ChIP-ChIP_Hs578T_Human3.38050704
11IRF8_27001747_Chip-Seq_BMDM_Mouse3.24533994
12SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.21667415
13* RUNX_20019798_ChIP-Seq_JUKART_Human3.05773655
14MYB_26560356_Chip-Seq_TH2_Human3.00811483
15* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.00324403
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.98905867
17* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.98447459
18NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.83821627
19* MAF_26560356_Chip-Seq_TH1_Human2.70625602
20MYB_21317192_ChIP-Seq_ERMYB_Mouse2.61496860
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.55024995
22MYC_22102868_ChIP-Seq_BL_Human2.51745605
23MYB_26560356_Chip-Seq_TH1_Human2.49036668
24RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.44816708
25VDR_21846776_ChIP-Seq_THP-1_Human2.26436296
26SPI1_23547873_ChIP-Seq_NB4_Human2.20930604
27E2F7_22180533_ChIP-Seq_HELA_Human2.06492732
28UTX_26944678_Chip-Seq_JUKART_Human2.03925838
29* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.96299789
30* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.94562998
31STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.93895163
32SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.93496178
33VDR_24763502_ChIP-Seq_THP-1_Human1.92324503
34SCL_19346495_ChIP-Seq_HPC-7_Human1.89984925
35RUNX1_22412390_ChIP-Seq_EML_Mouse1.89026747
36* GATA3_27048872_Chip-Seq_THYMUS_Human1.84737532
37SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.84452670
38ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.81924675
39E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.77931566
40TCF7_22412390_ChIP-Seq_EML_Mouse1.76678027
41MAF_26560356_Chip-Seq_TH2_Human1.73002342
42Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.63594630
43NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.61176480
44* PU_27001747_Chip-Seq_BMDM_Mouse1.58243996
45KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.55549653
46FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.55191591
47SPI1_23127762_ChIP-Seq_K562_Human1.54917906
48VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.53942079
49MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.47374914
50CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.47004938
51STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.44620631
52ELF1_17652178_ChIP-ChIP_JURKAT_Human1.41156008
53* NOTCH1_21737748_ChIP-Seq_TLL_Human1.38399559
54* GATA3_26560356_Chip-Seq_TH2_Human1.34617336
55BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.33892813
56GATA2_22383799_ChIP-Seq_G1ME_Mouse1.31564459
57KDM2B_26808549_Chip-Seq_DND41_Human1.31270039
58VDR_24787735_ChIP-Seq_THP-1_Human1.30037231
59* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.26123985
60* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23043416
61KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.21903255
62* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.21821610
63* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.20732281
64SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.19301970
65TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.16138082
66SMAD_19615063_ChIP-ChIP_OVARY_Human1.14028258
67KDM2B_26808549_Chip-Seq_SUP-B15_Human1.12228993
68TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.11948386
69NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.05404638
70GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.05052713
71* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03155665
72ELK3_25401928_ChIP-Seq_HUVEC_Human1.02525020
73RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.02473408
74* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00075017
75LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.97985292
76VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.96678066
77* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95243935
78* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.94544433
79CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91612946
80* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.89849173
81GATA3_26560356_Chip-Seq_TH1_Human0.88827116
82GATA1_19941827_ChIP-Seq_MEL_Mouse0.88124891
83ERG_20887958_ChIP-Seq_HPC-7_Mouse0.88000693
84GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.87328153
85GATA1_22025678_ChIP-Seq_K562_Human0.86917049
86GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86221589
87HOXB4_20404135_ChIP-ChIP_EML_Mouse0.86136290
88* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.84928204
89PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.83962520
90GATA1_19941826_ChIP-Seq_K562_Human0.81157887
91GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80015825
92SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79385529
93KDM2B_26808549_Chip-Seq_JURKAT_Human0.77100143
94NCOR1_26117541_ChIP-Seq_K562_Human0.76774661
95FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75747298
96SMRT_27268052_Chip-Seq_Bcells_Human0.70954220
97RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.70883724
98THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.70862689
99FLI1_27457419_Chip-Seq_LIVER_Mouse0.70257269
100GATA2_21666600_ChIP-Seq_HMVEC_Human0.68642306
101BCL6_27268052_Chip-Seq_Bcells_Human0.66704859
102VDR_23849224_ChIP-Seq_CD4+_Human0.65705070
103* TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.63730082
104EGR1_19032775_ChIP-ChIP_M12_Human0.63580937
105TFEB_21752829_ChIP-Seq_HELA_Human0.63311913
106ELK1_19687146_ChIP-ChIP_HELA_Human0.63086527
107GATA2_19941826_ChIP-Seq_K562_Human0.61145723
108TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.60751333
109ETS1_22383799_ChIP-Seq_G1ME_Mouse0.60219818
110SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.60074220
111RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.59929720
112FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.58477525
113CIITA_25753668_ChIP-Seq_RAJI_Human0.57851178
114TP63_17297297_ChIP-ChIP_HaCaT_Human0.56720089

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.85444377
2MP0000685_abnormal_immune_system3.87895376
3MP0002138_abnormal_hepatobiliary_system3.64618722
4MP0001790_abnormal_immune_system3.46006036
5MP0005387_immune_system_phenotype3.46006036
6* MP0005671_abnormal_response_to3.45262255
7MP0003763_abnormal_thymus_physiology3.26926729
8MP0001800_abnormal_humoral_immune3.23447941
9MP0005000_abnormal_immune_tolerance3.15375706
10MP0009785_altered_susceptibility_to3.11023304
11MP0002148_abnormal_hypersensitivity_rea3.09228758
12MP0003436_decreased_susceptibility_to3.07369763
13MP0003303_peritoneal_inflammation3.01599704
14MP0002452_abnormal_antigen_presenting2.87383990
15MP0002723_abnormal_immune_serum2.82864162
16MP0002166_altered_tumor_susceptibility2.70814951
17* MP0002420_abnormal_adaptive_immunity2.69456352
18* MP0001819_abnormal_immune_cell2.69339757
19MP0005025_abnormal_response_to2.66969172
20MP0004510_myositis2.49961459
21MP0002398_abnormal_bone_marrow2.36711247
22MP0002419_abnormal_innate_immunity2.34832125
23MP0002006_tumorigenesis2.33123148
24MP0003300_gastrointestinal_ulcer2.25966230
25* MP0000716_abnormal_immune_system2.20143373
26MP0002405_respiratory_system_inflammati2.18076181
27MP0001853_heart_inflammation2.10712985
28MP0001873_stomach_inflammation2.07627484
29MP0010155_abnormal_intestine_physiology2.05058985
30MP0003724_increased_susceptibility_to2.00090005
31MP0005310_abnormal_salivary_gland1.99959870
32MP0009333_abnormal_splenocyte_physiolog1.98028804
33MP0001348_abnormal_lacrimal_gland1.93143689
34MP0006082_CNS_inflammation1.90698182
35MP0000689_abnormal_spleen_morphology1.83316870
36* MP0002722_abnormal_immune_system1.80697946
37MP0004947_skin_inflammation1.80210274
38* MP0002429_abnormal_blood_cell1.75890917
39MP0001845_abnormal_inflammatory_respons1.75627909
40MP0000703_abnormal_thymus_morphology1.68262339
41MP0005464_abnormal_platelet_physiology1.67715894
42MP0002396_abnormal_hematopoietic_system1.67614375
43MP0003866_abnormal_defecation1.67450622
44MP0002009_preneoplasia1.48186377
45MP0002163_abnormal_gland_morphology1.47761697
46MP0003448_altered_tumor_morphology1.45936445
47MP0008057_abnormal_DNA_replication1.42687564
48MP0004808_abnormal_hematopoietic_stem1.42383349
49MP0005451_abnormal_body_composition1.40476617
50MP0002933_joint_inflammation1.35924430
51MP0000858_altered_metastatic_potential1.32234360
52MP0001545_abnormal_hematopoietic_system1.31571736
53MP0005397_hematopoietic_system_phenotyp1.31571736
54MP0001533_abnormal_skeleton_physiology1.31549770
55MP0008469_abnormal_protein_level1.26414316
56MP0000490_abnormal_crypts_of1.20904803
57MP0008260_abnormal_autophagy1.19008971
58MP0009764_decreased_sensitivity_to1.17459259
59MP0005076_abnormal_cell_differentiation1.10303996
60MP0010352_gastrointestinal_tract_polyps1.01010547
61MP0009278_abnormal_bone_marrow0.97389205
62MP0001881_abnormal_mammary_gland0.95680755
63MP0002998_abnormal_bone_remodeling0.95184769
64MP0002254_reproductive_system_inflammat0.94570161
65MP0002277_abnormal_respiratory_mucosa0.91828769
66MP0000465_gastrointestinal_hemorrhage0.91419047
67MP0005174_abnormal_tail_pigmentation0.88295148
68MP0001851_eye_inflammation0.84085632
69MP0003453_abnormal_keratinocyte_physiol0.79469310
70* MP0002019_abnormal_tumor_incidence0.79314946
71MP0003656_abnormal_erythrocyte_physiolo0.78613141
72MP0004883_abnormal_blood_vessel0.77217057
73MP0000015_abnormal_ear_pigmentation0.76351054
74MP0000569_abnormal_digit_pigmentation0.73520107
75MP0009763_increased_sensitivity_to0.72936082
76MP0002877_abnormal_melanocyte_morpholog0.71779287
77MP0003091_abnormal_cell_migration0.71298385
78MP0003191_abnormal_cellular_cholesterol0.69096246
79MP0001663_abnormal_digestive_system0.66579177
80MP0000604_amyloidosis0.66123197
81MP0003828_pulmonary_edema0.63550322
82MP0005058_abnormal_lysosome_morphology0.63367273
83MP0005379_endocrine/exocrine_gland_phen0.61808380
84MP0000249_abnormal_blood_vessel0.61079508
85MP0009765_abnormal_xenobiotic_induced0.60811196
86MP0005075_abnormal_melanosome_morpholog0.60321242
87MP0005164_abnormal_response_to0.57442044
88MP0001346_abnormal_lacrimal_gland0.57191364
89MP0000627_abnormal_mammary_gland0.57017768
90MP0010307_abnormal_tumor_latency0.57007195
91MP0003183_abnormal_peptide_metabolism0.56253549
92MP0003045_fibrosis0.56076915
93MP0002693_abnormal_pancreas_physiology0.55865377
94MP0002136_abnormal_kidney_physiology0.53607492
95MP0008961_abnormal_basal_metabolism0.53205879
96MP0001919_abnormal_reproductive_system0.53083966
97MP0005390_skeleton_phenotype0.52797216
98MP0003075_altered_response_to0.52627079
99MP0000343_altered_response_to0.52132434
100MP0004381_abnormal_hair_follicle0.50405650
101MP0001243_abnormal_dermal_layer0.49593238
102MP0003172_abnormal_lysosome_physiology0.48840723
103MP0003795_abnormal_bone_structure0.48591207
104MP0000609_abnormal_liver_physiology0.48453296
105MP0002132_abnormal_respiratory_system0.47467030
106MP0000371_diluted_coat_color0.46638925
107MP0001986_abnormal_taste_sensitivity0.44312023
108MP0005166_decreased_susceptibility_to0.43567034
109MP0000613_abnormal_salivary_gland0.43542880
110MP0008007_abnormal_cellular_replicative0.43387123
111MP0001216_abnormal_epidermal_layer0.43092271
112MP0003252_abnormal_bile_duct0.42405038
113MP0003690_abnormal_glial_cell0.42160354
114MP0004130_abnormal_muscle_cell0.41955440
115MP0008004_abnormal_stomach_pH0.41326941
116MP0008873_increased_physiological_sensi0.41074603
117MP0003221_abnormal_cardiomyocyte_apopto0.40873667

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.39495899
2Myositis (HP:0100614)4.98419787
3Abnormality of T cell number (HP:0011839)4.92425360
4T lymphocytopenia (HP:0005403)4.81099644
5Elevated erythrocyte sedimentation rate (HP:0003565)4.78757011
6Recurrent fungal infections (HP:0002841)4.77540424
7Optic neuritis (HP:0100653)4.65135888
8Retrobulbar optic neuritis (HP:0100654)4.65135888
9Recurrent abscess formation (HP:0002722)4.59402110
10Recurrent viral infections (HP:0004429)4.54030567
11Chronic otitis media (HP:0000389)4.39802955
12Recurrent bronchitis (HP:0002837)4.39543343
13Orchitis (HP:0100796)4.33892822
14Recurrent bacterial skin infections (HP:0005406)4.32971827
15Stomatitis (HP:0010280)4.03721902
16Abnormality of T cells (HP:0002843)3.97650715
17Chronic mucocutaneous candidiasis (HP:0002728)3.90198902
18Recurrent cutaneous fungal infections (HP:0011370)3.90198902
19Abnormal delayed hypersensitivity skin test (HP:0002963)3.89054610
20Vasculitis (HP:0002633)3.87797579
21Meningitis (HP:0001287)3.79253209
22IgM deficiency (HP:0002850)3.78922916
23Agammaglobulinemia (HP:0004432)3.76966892
24Nasal polyposis (HP:0100582)3.75674651
25Mediastinal lymphadenopathy (HP:0100721)3.74973951
26Gastrointestinal infarctions (HP:0005244)3.72139106
27Panhypogammaglobulinemia (HP:0003139)3.54224583
28Increased IgM level (HP:0003496)3.52883668
29Pulmonary infiltrates (HP:0002113)3.51125301
30Recurrent skin infections (HP:0001581)3.47361284
31Arterial thrombosis (HP:0004420)3.41793837
32Severe combined immunodeficiency (HP:0004430)3.35979149
33Obstructive lung disease (HP:0006536)3.34302288
34Chronic obstructive pulmonary disease (HP:0006510)3.34302288
35Thrombocytosis (HP:0001894)3.31841460
36Inflammation of the large intestine (HP:0002037)3.28971274
37IgG deficiency (HP:0004315)3.28754759
38Autoimmune thrombocytopenia (HP:0001973)3.28137040
39Abnormality of the nasal mucosa (HP:0000433)3.23793228
40Cellulitis (HP:0100658)3.22226341
41Hemoptysis (HP:0002105)3.20040685
42Abnormality of T cell physiology (HP:0011840)3.18478017
43Thyroiditis (HP:0100646)3.18114991
44Gastrointestinal inflammation (HP:0004386)3.17214755
45Combined immunodeficiency (HP:0005387)3.15910581
46Abnormality of macrophages (HP:0004311)3.13397203
47Abnormality of B cell number (HP:0010975)3.12648205
48B lymphocytopenia (HP:0010976)3.12648205
49Eosinophilia (HP:0001880)3.11639236
50Leukocytosis (HP:0001974)3.10569885
51Keratoconjunctivitis sicca (HP:0001097)3.09980939
52Abnormality of the fingertips (HP:0001211)3.09645368
53Recurrent gram-negative bacterial infections (HP:0005420)3.08312081
54Abnormality of eosinophils (HP:0001879)3.05463948
55Spontaneous hematomas (HP:0007420)3.02805219
56Encephalitis (HP:0002383)3.01687170
57Lymphopenia (HP:0001888)2.98062556
58Abnormality of cells of the lymphoid lineage (HP:0012140)2.97878363
59Chronic diarrhea (HP:0002028)2.94990375
60Increased IgE level (HP:0003212)2.93273294
61Chest pain (HP:0100749)2.84965897
62Hypergammaglobulinemia (HP:0010702)2.83573098
63Colitis (HP:0002583)2.82760398
64Keratoconjunctivitis (HP:0001096)2.82461103
65Pustule (HP:0200039)2.82271497
66Granulocytopenia (HP:0001913)2.80468516
67Autoimmune hemolytic anemia (HP:0001890)2.75913353
68IgA deficiency (HP:0002720)2.71735755
69Interstitial pulmonary disease (HP:0006530)2.71104131
70Recurrent sinusitis (HP:0011108)2.68909010
71Chronic sinusitis (HP:0011109)2.68587783
72Gingival bleeding (HP:0000225)2.64703638
73Fatigue (HP:0012378)2.60504483
74Verrucae (HP:0200043)2.60477324
75Papilloma (HP:0012740)2.60477324
76Gingivitis (HP:0000230)2.55002326
77Abnormality of the pleura (HP:0002103)2.54701142
78Gastrointestinal stroma tumor (HP:0100723)2.54034368
79Periodontitis (HP:0000704)2.53036666
80Joint swelling (HP:0001386)2.48395636
81Bronchitis (HP:0012387)2.46077412
82Pulmonary embolism (HP:0002204)2.40215957
83Stomach cancer (HP:0012126)2.39276191
84Abnormality of the prostate (HP:0008775)2.37467390
85Keratitis (HP:0000491)2.34463387
86Glomerulopathy (HP:0100820)2.34121619
87Osteomyelitis (HP:0002754)2.34081444
88Gangrene (HP:0100758)2.31343796
89Epistaxis (HP:0000421)2.28076661
90Recurrent pneumonia (HP:0006532)2.27513485
91Amaurosis fugax (HP:0100576)2.25152286
92Skin rash (HP:0000988)2.22869572
93Prolonged bleeding time (HP:0003010)2.22648541
94Myocardial infarction (HP:0001658)2.20327010
95Emphysema (HP:0002097)2.19009742
96Hypochromic anemia (HP:0001931)2.18377978
97Lymphoma (HP:0002665)2.18021448
98Skin ulcer (HP:0200042)2.15595974
99Petechiae (HP:0000967)2.11850495
100Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.11845261
101Sepsis (HP:0100806)2.09974663
102Alveolar cell carcinoma (HP:0006519)2.09736467
103Recurrent lower respiratory tract infections (HP:0002783)2.08704589
104Vacuolated lymphocytes (HP:0001922)2.08130594
105Neoplasm of the tracheobronchial system (HP:0100552)2.05179481
106Restrictive lung disease (HP:0002091)2.05125878
107Abnormality of the endocardium (HP:0004306)2.04281683
108Acute hepatic failure (HP:0006554)2.04250276
109Polyneuropathy (HP:0001271)2.03120798
110Urticaria (HP:0001025)2.02860920
111Anorexia (HP:0002039)2.02466796
112Basal ganglia calcification (HP:0002135)2.02108373
113Arthralgia (HP:0002829)2.01903638
114Prostate neoplasm (HP:0100787)1.98590993
115Slow saccadic eye movements (HP:0000514)1.93065565
116Vertigo (HP:0002321)1.92516923
117Increased cerebral lipofuscin (HP:0011813)1.91565414

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.67058252
2TXK4.49260064
3MAP3K144.08031836
4JAK33.24971811
5TYK23.05760851
6TBK12.79902660
7IKBKE2.74157017
8IKBKB2.68407133
9IRAK42.37150377
10BLK2.34818254
11ZAP702.33821705
12JAK12.27372263
13PRPF4B2.21669534
14ITK2.07501606
15FGFR42.03990572
16MAP3K132.00840458
17CHUK1.94206914
18STK101.89184729
19GRK61.88204951
20IRAK31.85170334
21TEC1.78444032
22NLK1.75363120
23BTK1.71444000
24FGFR31.70685965
25MST41.69390402
26SYK1.65175365
27RIPK41.61870475
28PIM11.56284850
29LCK1.52598111
30EPHA31.48145901
31CSK1.45331672
32EPHB11.44442022
33MAP3K101.44385426
34KIT1.40781184
35HCK1.38094773
36NEK91.32199066
37CAMKK21.27767414
38CSF1R1.24698819
39JAK21.21112621
40PIM21.19838954
41TAOK31.19233231
42LRRK21.16642266
43PRKCQ1.00784704
44NME20.97084636
45IRAK10.96155040
46SIK30.95524323
47PIK3CG0.92895006
48LYN0.92844574
49MAP2K30.88129069
50RPS6KA40.87126759
51TGFBR20.86735617
52MARK30.86191870
53TRIB30.85785709
54MAP3K10.85751671
55FLT30.83911584
56STK40.83885154
57CAMKK10.83364094
58PKN20.80848121
59ERN10.77226231
60SIK20.77136615
61MAPK70.76779600
62PASK0.75357634
63STK240.75318482
64FES0.74541336
65CLK10.74127611
66MAP3K30.69355076
67EEF2K0.67424224
68MAPK110.63672938
69MAP2K20.63389949
70MAPK120.63318645
71CDK120.56076124
72CDK90.52941033
73HIPK20.49655335
74NUAK10.49567539
75MAPKAPK20.47782167
76BMPR20.47452823
77TAOK20.46903966
78GRK70.46535532
79PTK60.45867526
80TNK20.45585587
81ABL10.43866286
82RPS6KA50.43454142
83KDR0.42246603
84CDK60.40098919
85PDPK10.39555461
86TAOK10.39296948
87CDK40.39200461
88NEK60.38806369
89EIF2AK20.37442457
90PDK10.37153029
91PDGFRB0.35508210
92BMX0.34983115
93YES10.34076005
94PRKCD0.33926252
95IRAK20.33813534
96KSR20.32305528
97TESK20.31268930
98ALK0.30780858
99BCKDK0.30753643
100TRPM70.30709685
101CDK190.30107350
102MAP3K80.29972433
103MAP3K50.29602626
104DYRK1B0.28721409
105RPS6KA60.28673046
106PRKCH0.28095822
107MARK20.27791107
108SGK20.27515594
109TYRO30.27156421
110EGFR0.27135315
111SGK30.26845196
112RPS6KA10.26718655
113MAP3K70.26256717
114MELK0.25778621
115FGR0.25617495
116PKN10.23844350
117FYN0.23737302
118MAP3K110.23398939
119TLK10.22908822
120PRKD20.22890891
121MAPK40.22549568
122SIK10.22520412
123RPS6KC10.22078477
124RET0.22043875
125INSR0.21851226
126IGF1R0.21737280
127MATK0.21553716
128MAP2K60.21073208
129MAPK30.19635864

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.86438761
2Allograft rejection_Homo sapiens_hsa053303.35581366
3Intestinal immune network for IgA production_Homo sapiens_hsa046723.25827686
4Graft-versus-host disease_Homo sapiens_hsa053323.10240319
5NF-kappa B signaling pathway_Homo sapiens_hsa040642.87893035
6Leishmaniasis_Homo sapiens_hsa051402.77327430
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.76004430
8Measles_Homo sapiens_hsa051622.65747621
9T cell receptor signaling pathway_Homo sapiens_hsa046602.44569077
10Autoimmune thyroid disease_Homo sapiens_hsa053202.43702847
11Osteoclast differentiation_Homo sapiens_hsa043802.30165492
12B cell receptor signaling pathway_Homo sapiens_hsa046622.24656450
13Antigen processing and presentation_Homo sapiens_hsa046122.12695166
14Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.07455234
15Jak-STAT signaling pathway_Homo sapiens_hsa046302.03522549
16RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.99629853
17Toll-like receptor signaling pathway_Homo sapiens_hsa046201.93153728
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.92964793
19NOD-like receptor signaling pathway_Homo sapiens_hsa046211.88040355
20Toxoplasmosis_Homo sapiens_hsa051451.82384466
21Hematopoietic cell lineage_Homo sapiens_hsa046401.80773731
22Viral myocarditis_Homo sapiens_hsa054161.73886055
23Herpes simplex infection_Homo sapiens_hsa051681.70964507
24Chemokine signaling pathway_Homo sapiens_hsa040621.64434662
25Type I diabetes mellitus_Homo sapiens_hsa049401.64333823
26TNF signaling pathway_Homo sapiens_hsa046681.61769870
27Influenza A_Homo sapiens_hsa051641.58804386
28Legionellosis_Homo sapiens_hsa051341.48163162
29Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.47833089
30Apoptosis_Homo sapiens_hsa042101.43345270
31Asthma_Homo sapiens_hsa053101.42225446
32Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.41140262
33Tuberculosis_Homo sapiens_hsa051521.41136087
34Shigellosis_Homo sapiens_hsa051311.38454132
35Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.36887341
36Pertussis_Homo sapiens_hsa051331.35960181
37Acute myeloid leukemia_Homo sapiens_hsa052211.33346591
38Hepatitis B_Homo sapiens_hsa051611.30190857
39Malaria_Homo sapiens_hsa051441.22491957
40Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.21710001
41Prolactin signaling pathway_Homo sapiens_hsa049171.21282706
42Leukocyte transendothelial migration_Homo sapiens_hsa046701.16879383
43Staphylococcus aureus infection_Homo sapiens_hsa051501.11055685
44Rheumatoid arthritis_Homo sapiens_hsa053231.04999653
45Epstein-Barr virus infection_Homo sapiens_hsa051691.00729309
46Salmonella infection_Homo sapiens_hsa051320.96995295
47Hepatitis C_Homo sapiens_hsa051600.94571660
48Transcriptional misregulation in cancer_Homo sapiens_hsa052020.94048166
49AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.93254349
50Chronic myeloid leukemia_Homo sapiens_hsa052200.93100029
51Platelet activation_Homo sapiens_hsa046110.91408167
52Pancreatic cancer_Homo sapiens_hsa052120.86847210
53African trypanosomiasis_Homo sapiens_hsa051430.84221539
54Viral carcinogenesis_Homo sapiens_hsa052030.82733705
55HTLV-I infection_Homo sapiens_hsa051660.82406796
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.75817887
57Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.73433211
58Neurotrophin signaling pathway_Homo sapiens_hsa047220.70661166
59Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.68971026
60Small cell lung cancer_Homo sapiens_hsa052220.66950383
61Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.63200948
62p53 signaling pathway_Homo sapiens_hsa041150.58514828
63VEGF signaling pathway_Homo sapiens_hsa043700.56765350
64Non-small cell lung cancer_Homo sapiens_hsa052230.55538919
65Dorso-ventral axis formation_Homo sapiens_hsa043200.50434187
66Adipocytokine signaling pathway_Homo sapiens_hsa049200.49835390
67Other glycan degradation_Homo sapiens_hsa005110.46746196
68Colorectal cancer_Homo sapiens_hsa052100.45982933
69FoxO signaling pathway_Homo sapiens_hsa040680.45293230
70Lysosome_Homo sapiens_hsa041420.43274230
71Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.40956569
72Ribosome_Homo sapiens_hsa030100.37097726
73MAPK signaling pathway_Homo sapiens_hsa040100.37066798
74Endocytosis_Homo sapiens_hsa041440.35883632
75Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.35797689
76Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.35171606
77Regulation of actin cytoskeleton_Homo sapiens_hsa048100.34398789
78HIF-1 signaling pathway_Homo sapiens_hsa040660.34264773
79Phosphatidylinositol signaling system_Homo sapiens_hsa040700.31892679
80Phagosome_Homo sapiens_hsa041450.31872158
81Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.31826922
82Prostate cancer_Homo sapiens_hsa052150.31755725
83Sphingolipid signaling pathway_Homo sapiens_hsa040710.31400361
84Inositol phosphate metabolism_Homo sapiens_hsa005620.31120624
85MicroRNAs in cancer_Homo sapiens_hsa052060.30651310
86Insulin resistance_Homo sapiens_hsa049310.28967787
87Regulation of autophagy_Homo sapiens_hsa041400.28530073
88Base excision repair_Homo sapiens_hsa034100.27258499
89Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.26014120
90Notch signaling pathway_Homo sapiens_hsa043300.25824578
91Choline metabolism in cancer_Homo sapiens_hsa052310.25733374
92SNARE interactions in vesicular transport_Homo sapiens_hsa041300.24929683
93Amoebiasis_Homo sapiens_hsa051460.23773078
94Phospholipase D signaling pathway_Homo sapiens_hsa040720.23337045
95Type II diabetes mellitus_Homo sapiens_hsa049300.22067804
96Pathways in cancer_Homo sapiens_hsa052000.21955825
97Non-homologous end-joining_Homo sapiens_hsa034500.21018365
98Endometrial cancer_Homo sapiens_hsa052130.20470791
99Caffeine metabolism_Homo sapiens_hsa002320.20393569
100Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.19426434
101Renal cell carcinoma_Homo sapiens_hsa052110.18871854
102GnRH signaling pathway_Homo sapiens_hsa049120.18296465
103Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.17635723
104Systemic lupus erythematosus_Homo sapiens_hsa053220.17094476
105mTOR signaling pathway_Homo sapiens_hsa041500.15470404
106Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.15081373
107Proteoglycans in cancer_Homo sapiens_hsa052050.14640689
108Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.14075611
109Ras signaling pathway_Homo sapiens_hsa040140.13873494
110ErbB signaling pathway_Homo sapiens_hsa040120.12596613
111Carbohydrate digestion and absorption_Homo sapiens_hsa049730.12151740
112Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.10544778
113Glycerophospholipid metabolism_Homo sapiens_hsa005640.08378931

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