DAAM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Cell motility, adhesion, cytokinesis, and other functions of the cell cortex are mediated by reorganization of the actin cytoskeleton and several formin homology (FH) proteins have been associated with these processes. The protein encoded by this gene contains two FH domains and belongs to a novel FH protein subfamily implicated in cell polarity. A key regulator of cytoskeletal architecture, the small GTPase Rho, is activated during development by Wnt/Fz signaling to control cell polarity and movement. The protein encoded by this gene is thought to function as a scaffolding protein for the Wnt-induced assembly of a disheveled (Dvl)-Rho complex. This protein also promotes the nucleation and elongation of new actin filaments and regulates cell growth through the stabilization of microtubules. Alternative splicing results in multiple transcript variants encoding distinct proteins. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)5.34407227
2central nervous system myelination (GO:0022010)5.34407227
3response to pheromone (GO:0019236)4.26234671
4negative regulation of neurotransmitter secretion (GO:0046929)3.86157773
5myelination (GO:0042552)3.82478791
6axon ensheathment (GO:0008366)3.81116760
7ensheathment of neurons (GO:0007272)3.81116760
8behavioral response to nicotine (GO:0035095)3.79082744
9fatty acid elongation (GO:0030497)3.70365416
10regulation of mesoderm development (GO:2000380)3.47343567
11water-soluble vitamin biosynthetic process (GO:0042364)3.44496892
12somite development (GO:0061053)3.36034050
13apical protein localization (GO:0045176)3.30666951
14protein polyglutamylation (GO:0018095)3.27228023
15asymmetric protein localization (GO:0008105)3.26778004
16establishment of mitochondrion localization (GO:0051654)3.24879905
17epithelial cilium movement (GO:0003351)3.24673664
18long-chain fatty acid biosynthetic process (GO:0042759)3.23433471
19kidney morphogenesis (GO:0060993)3.23298887
20neuron cell-cell adhesion (GO:0007158)3.22749613
21G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.18866058
22negative regulation of neurotransmitter transport (GO:0051589)3.17799237
23regulation of acrosome reaction (GO:0060046)3.17429326
24atrial cardiac muscle cell action potential (GO:0086014)3.14695083
25pyrimidine nucleobase catabolic process (GO:0006208)3.14175182
26regulation of action potential (GO:0098900)3.05664513
27axoneme assembly (GO:0035082)3.04854387
28eye photoreceptor cell differentiation (GO:0001754)3.04653967
29photoreceptor cell differentiation (GO:0046530)3.04653967
30dendrite morphogenesis (GO:0048813)3.00151957
31myelination in peripheral nervous system (GO:0022011)2.98598468
32peripheral nervous system axon ensheathment (GO:0032292)2.98598468
33layer formation in cerebral cortex (GO:0021819)2.98428014
34cornea development in camera-type eye (GO:0061303)2.97195755
35positive regulation of action potential (GO:0045760)2.95730795
36retinal cone cell development (GO:0046549)2.92758070
37presynaptic membrane assembly (GO:0097105)2.92147290
38negative regulation of protein localization to cell surface (GO:2000009)2.84474035
39epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.82019149
40glycerophospholipid catabolic process (GO:0046475)2.80920364
41detection of light stimulus involved in sensory perception (GO:0050962)2.79060921
42detection of light stimulus involved in visual perception (GO:0050908)2.79060921
43oligodendrocyte differentiation (GO:0048709)2.77702950
44peptidyl-tyrosine autophosphorylation (GO:0038083)2.76678648
45regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.75814738
46presynaptic membrane organization (GO:0097090)2.75627066
47dendritic spine morphogenesis (GO:0060997)2.75188414
48retinal ganglion cell axon guidance (GO:0031290)2.73360574
49nerve growth factor signaling pathway (GO:0038180)2.71825026
50negative regulation of transcription regulatory region DNA binding (GO:2000678)2.71783293
51neuron recognition (GO:0008038)2.71225156
52negative regulation of dendrite development (GO:2000171)2.70291589
53keratinocyte development (GO:0003334)2.70170792
54inositol phosphate catabolic process (GO:0071545)2.67432068
55transmission of nerve impulse (GO:0019226)2.67359449
56startle response (GO:0001964)2.64325343
57protein localization to cilium (GO:0061512)2.63946473
58negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.63257936
59RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.63091423
60gamma-aminobutyric acid transport (GO:0015812)2.62317983
61behavioral response to ethanol (GO:0048149)2.62177362
62cilium morphogenesis (GO:0060271)2.62144056
63cerebellar granule cell differentiation (GO:0021707)2.62032349
64L-fucose metabolic process (GO:0042354)2.61825872
65L-fucose catabolic process (GO:0042355)2.61825872
66fucose catabolic process (GO:0019317)2.61825872
67prostate gland growth (GO:0060736)2.61787107
68intraciliary transport (GO:0042073)2.60807421
69virion attachment to host cell (GO:0019062)2.60257591
70adhesion of symbiont to host cell (GO:0044650)2.60257591
71cilium movement (GO:0003341)2.59890788
72neural tube formation (GO:0001841)2.59282948
73nucleobase catabolic process (GO:0046113)2.58630725
74astrocyte development (GO:0014002)2.58028741
75negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.56941647
76neuronal action potential (GO:0019228)2.56565589
77action potential (GO:0001508)2.55463082
78nonmotile primary cilium assembly (GO:0035058)2.55391202
79negative regulation of cytosolic calcium ion concentration (GO:0051481)2.55033448
80photoreceptor cell development (GO:0042461)2.54752104
81regulation of meiosis I (GO:0060631)2.54663484
82positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.52495147
83regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.51944395
84cell migration in hindbrain (GO:0021535)2.50374204
85cytoskeletal anchoring at plasma membrane (GO:0007016)2.50313048
86creatine metabolic process (GO:0006600)2.49800734
87response to methylmercury (GO:0051597)2.49185167
88cellular response to epinephrine stimulus (GO:0071872)2.49001419
89auditory behavior (GO:0031223)2.48766803
90myelin maintenance (GO:0043217)2.48379741
91cerebral cortex radially oriented cell migration (GO:0021799)2.48003215
92regulation of telomere maintenance (GO:0032204)2.47157668
93glutamate receptor signaling pathway (GO:0007215)2.47045903
94L-phenylalanine catabolic process (GO:0006559)2.46983101
95erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.46983101
96regulation of short-term neuronal synaptic plasticity (GO:0048172)2.45915291
97cell communication involved in cardiac conduction (GO:0086065)2.45859688
98axonal fasciculation (GO:0007413)2.45831430
99spinal cord development (GO:0021510)2.45432646
100platelet dense granule organization (GO:0060155)2.44329830
101sympathetic nervous system development (GO:0048485)2.43682178
102establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.43413411
103mitochondrion transport along microtubule (GO:0047497)2.43413411
104regulation of rhodopsin mediated signaling pathway (GO:0022400)2.42469444
105regulation of calcium ion-dependent exocytosis (GO:0017158)2.41781743
106membrane tubulation (GO:0097320)2.41654338
107synaptic vesicle maturation (GO:0016188)2.41058628
108multicellular organismal signaling (GO:0035637)2.40934033
109indolalkylamine metabolic process (GO:0006586)2.40818139
110negative regulation of synaptic transmission, GABAergic (GO:0032229)2.40733946
111eye photoreceptor cell development (GO:0042462)2.39328223
112DNA deamination (GO:0045006)2.39032117
113reflex (GO:0060004)2.38844430
114glycosphingolipid biosynthetic process (GO:0006688)2.38660638
115pancreas development (GO:0031016)2.38395224
116synapse assembly (GO:0007416)2.38393871
117spinal cord motor neuron differentiation (GO:0021522)2.37408036
118vocalization behavior (GO:0071625)2.37262488
119protein localization to endosome (GO:0036010)2.36806576
120polyol catabolic process (GO:0046174)2.35743467
121mechanosensory behavior (GO:0007638)2.35445144
122regulation of cilium movement (GO:0003352)2.35391970
123cilium organization (GO:0044782)2.35039436
124rhodopsin mediated signaling pathway (GO:0016056)2.34301002
125piRNA metabolic process (GO:0034587)2.34129475
126hindbrain development (GO:0030902)2.33415962
127DNA double-strand break processing (GO:0000729)2.33175442
128import into cell (GO:0098657)2.32751891
129negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.32277996
130negative regulation of potassium ion transmembrane transport (GO:1901380)2.31901501
131dentate gyrus development (GO:0021542)2.31783567
132long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.31724453
133embryonic epithelial tube formation (GO:0001838)2.31579188
134endoderm formation (GO:0001706)2.31213528
135postsynaptic membrane organization (GO:0001941)2.30878665
136neurotransmitter catabolic process (GO:0042135)2.30494507
137neuron-neuron synaptic transmission (GO:0007270)2.30228854
138neuronal ion channel clustering (GO:0045161)2.28990651
139membrane assembly (GO:0071709)2.28591156
140cilium assembly (GO:0042384)2.28348865
141synaptic transmission, cholinergic (GO:0007271)2.28185243
142negative regulation of axon guidance (GO:1902668)2.27804238
143positive regulation of glomerulus development (GO:0090193)2.27094050
144positive regulation of oligodendrocyte differentiation (GO:0048714)2.26758974
145glutamate secretion (GO:0014047)2.26610354
146negative regulation of axonogenesis (GO:0050771)2.26528593
147cellular response to catecholamine stimulus (GO:0071870)2.26355847
148cellular response to monoamine stimulus (GO:0071868)2.26355847
149positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.25623595
150neuronal action potential propagation (GO:0019227)2.25391595
151regulation of glucokinase activity (GO:0033131)2.24916797
152regulation of hexokinase activity (GO:1903299)2.24916797
153detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.24321370
154response to epinephrine (GO:0071871)2.24305185
155neuron fate determination (GO:0048664)2.24072891
156adult walking behavior (GO:0007628)2.23484921
157cholesterol biosynthetic process (GO:0006695)2.23471193
158fatty-acyl-CoA biosynthetic process (GO:0046949)2.22837567
159membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.18926616
160regulation of dendritic spine morphogenesis (GO:0061001)2.18568607
161substantia nigra development (GO:0021762)2.18195146
162organelle transport along microtubule (GO:0072384)2.17850585
163protein targeting to Golgi (GO:0000042)2.16041149
164cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.15937218
165limb bud formation (GO:0060174)2.15159524
166camera-type eye morphogenesis (GO:0048593)2.13475475
167locomotory exploration behavior (GO:0035641)2.13370340
168regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.12161934
169negative regulation of Rho protein signal transduction (GO:0035024)2.11247381
170regulation of collateral sprouting (GO:0048670)2.11073783
171neuromuscular junction development (GO:0007528)2.10425542
172positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.09788640
173regulation of cardioblast differentiation (GO:0051890)2.08829708
174cellular ketone body metabolic process (GO:0046950)2.08139455
175cellular response to nerve growth factor stimulus (GO:1990090)2.07635952
176response to nerve growth factor (GO:1990089)2.07635952
177response to catecholamine (GO:0071869)2.07421020
178response to monoamine (GO:0071867)2.07421020
179positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.07151527
180negative regulation of axon extension (GO:0030517)2.05813948
181phosphatidylinositol 3-kinase signaling (GO:0014065)2.05663483
182establishment of protein localization to Golgi (GO:0072600)2.05425729
183long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.05382574
184regulation of cell communication by electrical coupling (GO:0010649)2.04757335
185positive regulation of potassium ion transport (GO:0043268)2.04537449

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human2.83317683
2GBX2_23144817_ChIP-Seq_PC3_Human2.79157976
3IGF1R_20145208_ChIP-Seq_DFB_Human2.70884738
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.33569408
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.22888803
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.21149575
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.18676193
8FUS_26573619_Chip-Seq_HEK293_Human2.17406201
9EWS_26573619_Chip-Seq_HEK293_Human2.12803593
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.04019137
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.03915180
12EZH2_18974828_ChIP-Seq_MESCs_Mouse1.94929992
13RNF2_18974828_ChIP-Seq_MESCs_Mouse1.94929992
14EZH2_27304074_Chip-Seq_ESCs_Mouse1.92158562
15MTF2_20144788_ChIP-Seq_MESCs_Mouse1.91458716
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.89495711
17* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.87893962
18SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.85190510
19FLI1_27457419_Chip-Seq_LIVER_Mouse1.83170668
20SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.80605837
21SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.74948954
22EED_16625203_ChIP-ChIP_MESCs_Mouse1.74813020
23EZH2_27294783_Chip-Seq_ESCs_Mouse1.74299503
24JARID2_20075857_ChIP-Seq_MESCs_Mouse1.73534051
25DROSHA_22980978_ChIP-Seq_HELA_Human1.72479046
26CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.72177255
27* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.69723837
28SUZ12_27294783_Chip-Seq_ESCs_Mouse1.66827881
29AR_21572438_ChIP-Seq_LNCaP_Human1.65137918
30UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.63384465
31* AR_25329375_ChIP-Seq_VCAP_Human1.62942223
32RNF2_27304074_Chip-Seq_ESCs_Mouse1.62556387
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.60472359
34RNF2_27304074_Chip-Seq_NSC_Mouse1.57850532
35MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.55318886
36TAF15_26573619_Chip-Seq_HEK293_Human1.55148776
37ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.55120865
38* PIAS1_25552417_ChIP-Seq_VCAP_Human1.53707198
39TRIM28_21343339_ChIP-Seq_HEK293_Human1.52701879
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.49159373
41PCGF2_27294783_Chip-Seq_ESCs_Mouse1.48093030
42* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.47926920
43BCAT_22108803_ChIP-Seq_LS180_Human1.46699190
44* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.46578400
45* EP300_21415370_ChIP-Seq_HL-1_Mouse1.46123405
46CBP_20019798_ChIP-Seq_JUKART_Human1.45108236
47IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.45108236
48CTBP2_25329375_ChIP-Seq_LNCAP_Human1.42691480
49MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.42110101
50* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40723938
51BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.38314148
52HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.37897428
53ZFP57_27257070_Chip-Seq_ESCs_Mouse1.36383534
54AHR_22903824_ChIP-Seq_MCF-7_Human1.35087126
55REST_21632747_ChIP-Seq_MESCs_Mouse1.33908291
56NANOG_18555785_Chip-Seq_ESCs_Mouse1.33906494
57SMAD3_21741376_ChIP-Seq_EPCs_Human1.33620111
58* SMAD4_21799915_ChIP-Seq_A2780_Human1.32752513
59RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.31822540
60EZH2_27294783_Chip-Seq_NPCs_Mouse1.30360230
61SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29677287
62TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29496289
63POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.29496289
64SUZ12_27294783_Chip-Seq_NPCs_Mouse1.29096243
65* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.28647104
66POU3F2_20337985_ChIP-ChIP_501MEL_Human1.28050051
67ARNT_22903824_ChIP-Seq_MCF-7_Human1.27467432
68* STAT3_23295773_ChIP-Seq_U87_Human1.26814231
69TCF4_22108803_ChIP-Seq_LS180_Human1.25822066
70GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.24686348
71KLF5_20875108_ChIP-Seq_MESCs_Mouse1.23972366
72NANOG_19829295_ChIP-Seq_ESCs_Human1.23815076
73SOX2_19829295_ChIP-Seq_ESCs_Human1.23815076
74PCGF2_27294783_Chip-Seq_NPCs_Mouse1.23578453
75KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.23521140
76* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.23086957
77EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.23010188
78SMAD4_21741376_ChIP-Seq_EPCs_Human1.22274513
79EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.22005648
80ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.21752785
81* SOX2_21211035_ChIP-Seq_LN229_Gbm1.20768684
82VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.20150183
83TP53_22573176_ChIP-Seq_HFKS_Human1.19790850
84PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.19747617
85NFE2_27457419_Chip-Seq_LIVER_Mouse1.19182332
86* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.18496649
87RARB_27405468_Chip-Seq_BRAIN_Mouse1.18106181
88P300_19829295_ChIP-Seq_ESCs_Human1.17943467
89CBX2_27304074_Chip-Seq_ESCs_Mouse1.16960065
90P53_22387025_ChIP-Seq_ESCs_Mouse1.16438254
91NR3C1_23031785_ChIP-Seq_PC12_Mouse1.15873529
92* FLI1_21867929_ChIP-Seq_TH2_Mouse1.14169392
93TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13728753
94ESR1_20079471_ChIP-ChIP_T-47D_Human1.11929236
95TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.11385535
96NRF2_20460467_ChIP-Seq_MEFs_Mouse1.10485444
97NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.10485444
98NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.10070409
99TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09949221
100ER_23166858_ChIP-Seq_MCF-7_Human1.09879378
101NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.09787076
102PRDM14_20953172_ChIP-Seq_ESCs_Human1.09749027
103IRF1_19129219_ChIP-ChIP_H3396_Human1.08659689
104* TAL1_26923725_Chip-Seq_HPCs_Mouse1.08045557
105E2F1_18555785_Chip-Seq_ESCs_Mouse1.08014565
106* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.07497556
107EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.06837242
108VDR_22108803_ChIP-Seq_LS180_Human1.06650542
109* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.06587960
110* TCF4_23295773_ChIP-Seq_U87_Human1.06340866
111* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.06326175
112HTT_18923047_ChIP-ChIP_STHdh_Human1.05908212
113REST_18959480_ChIP-ChIP_MESCs_Mouse1.05608638
114RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.04987608
115NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03990815
116POU5F1_16153702_ChIP-ChIP_HESCs_Human1.03814026
117SMAD_19615063_ChIP-ChIP_OVARY_Human1.03392309
118PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.03294597
119JUN_21703547_ChIP-Seq_K562_Human1.02391987
120RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01609470
121ESR2_21235772_ChIP-Seq_MCF-7_Human1.00382734
122MYC_18940864_ChIP-ChIP_HL60_Human1.00214710
123* SMAD4_21741376_ChIP-Seq_HESCs_Human1.00162510
124AR_19668381_ChIP-Seq_PC3_Human0.99807215
125CRX_20693478_ChIP-Seq_RETINA_Mouse0.99478235
126* LXR_22158963_ChIP-Seq_LIVER_Mouse0.99296040
127CDX2_22108803_ChIP-Seq_LS180_Human0.99166754
128SUZ12_18555785_Chip-Seq_ESCs_Mouse0.99143439
129P53_22127205_ChIP-Seq_FIBROBLAST_Human0.99030678
130TP53_16413492_ChIP-PET_HCT116_Human0.98701414
131* FOXA2_19822575_ChIP-Seq_HepG2_Human0.98519386
132* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.98391753
133KDM2B_26808549_Chip-Seq_REH_Human0.98133186
134TP53_18474530_ChIP-ChIP_U2OS_Human0.98114376
135BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.97999384
136TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97525133
137* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.96924571
138LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96878154
139RING1B_27294783_Chip-Seq_ESCs_Mouse0.96498624
140WT1_19549856_ChIP-ChIP_CCG9911_Human0.95359606
141ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.95281421
142GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93023044
143TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92662351
144* RUNX2_22187159_ChIP-Seq_PCA_Human0.91543275
145RING1B_27294783_Chip-Seq_NPCs_Mouse0.91484393
146YAP1_20516196_ChIP-Seq_MESCs_Mouse0.91352789
147ZNF274_21170338_ChIP-Seq_K562_Hela0.90916058
148ISL1_27105846_Chip-Seq_CPCs_Mouse0.90807916
149* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.89453075
150BMI1_23680149_ChIP-Seq_NPCS_Mouse0.89435279
151FOXO3_23340844_ChIP-Seq_DLD1_Human0.89267806
152TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.88206249
153ERG_21242973_ChIP-ChIP_JURKAT_Human0.87920622
154CTNNB1_20460455_ChIP-Seq_HCT116_Human0.87416969

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004270_analgesia3.61461578
2MP0002102_abnormal_ear_morphology3.51731799
3MP0004859_abnormal_synaptic_plasticity3.02750082
4MP0000920_abnormal_myelination2.91914799
5MP0003787_abnormal_imprinting2.61823193
6MP0003880_abnormal_central_pattern2.61817381
7MP0008877_abnormal_DNA_methylation2.60301610
8MP0009780_abnormal_chondrocyte_physiolo2.52414196
9MP0001984_abnormal_olfaction2.47228381
10MP0003329_amyloid_beta_deposits2.36572628
11MP0000569_abnormal_digit_pigmentation2.26049348
12MP0003690_abnormal_glial_cell2.22100472
13MP0000778_abnormal_nervous_system2.14988411
14MP0004885_abnormal_endolymph2.14811711
15MP0003950_abnormal_plasma_membrane2.10515188
16MP0003635_abnormal_synaptic_transmissio2.09564258
17MP0001486_abnormal_startle_reflex2.03345653
18MP0002734_abnormal_mechanical_nocicepti1.94901703
19MP0002736_abnormal_nociception_after1.93330957
20MP0006072_abnormal_retinal_apoptosis1.91940468
21MP0002837_dystrophic_cardiac_calcinosis1.90844192
22MP0003890_abnormal_embryonic-extraembry1.87541039
23MP0006292_abnormal_olfactory_placode1.86290372
24MP0002064_seizures1.78794139
25MP0002272_abnormal_nervous_system1.75744960
26MP0003122_maternal_imprinting1.72040112
27MP0009046_muscle_twitch1.71534271
28MP0003634_abnormal_glial_cell1.71458098
29MP0005253_abnormal_eye_physiology1.70407610
30MP0003121_genomic_imprinting1.68023546
31MP0005499_abnormal_olfactory_system1.64661000
32MP0005394_taste/olfaction_phenotype1.64661000
33MP0002139_abnormal_hepatobiliary_system1.64309815
34MP0003119_abnormal_digestive_system1.61455546
35MP0002063_abnormal_learning/memory/cond1.61368314
36MP0009745_abnormal_behavioral_response1.61158092
37MP0008789_abnormal_olfactory_epithelium1.60424017
38MP0001440_abnormal_grooming_behavior1.57719599
39MP0002876_abnormal_thyroid_physiology1.57482448
40MP0000631_abnormal_neuroendocrine_gland1.57323418
41MP0000579_abnormal_nail_morphology1.53691175
42MP0002638_abnormal_pupillary_reflex1.50003563
43MP0004742_abnormal_vestibular_system1.48863317
44MP0002229_neurodegeneration1.46579597
45MP0000427_abnormal_hair_cycle1.44463490
46MP0003137_abnormal_impulse_conducting1.43919108
47MP0004036_abnormal_muscle_relaxation1.42577052
48MP0005423_abnormal_somatic_nervous1.41414531
49MP0000751_myopathy1.41350524
50MP0005386_behavior/neurological_phenoty1.40964583
51MP0004924_abnormal_behavior1.40964583
52MP0001299_abnormal_eye_distance/1.40614219
53MP0000955_abnormal_spinal_cord1.38791393
54MP0004215_abnormal_myocardial_fiber1.38085815
55MP0002572_abnormal_emotion/affect_behav1.35169817
56MP0005360_urolithiasis1.34346287
57MP0004084_abnormal_cardiac_muscle1.32231671
58MP0010678_abnormal_skin_adnexa1.31576585
59MP0005085_abnormal_gallbladder_physiolo1.31575490
60MP0002733_abnormal_thermal_nociception1.30760108
61MP0002234_abnormal_pharynx_morphology1.30060660
62MP0001485_abnormal_pinna_reflex1.28793243
63MP0003252_abnormal_bile_duct1.27569774
64MP0008872_abnormal_physiological_respon1.26863886
65MP0004085_abnormal_heartbeat1.26779684
66MP0002882_abnormal_neuron_morphology1.26728021
67MP0005645_abnormal_hypothalamus_physiol1.26675686
68MP0000372_irregular_coat_pigmentation1.26414581
69MP0005646_abnormal_pituitary_gland1.25213168
70MP0003632_abnormal_nervous_system1.24856102
71MP0005451_abnormal_body_composition1.24802821
72MP0001348_abnormal_lacrimal_gland1.24623570
73MP0003283_abnormal_digestive_organ1.24300535
74MP0002938_white_spotting1.23757358
75MP0002751_abnormal_autonomic_nervous1.22803065
76MP0000516_abnormal_urinary_system1.21045769
77MP0005367_renal/urinary_system_phenotyp1.21045769
78MP0000604_amyloidosis1.20932780
79MP0004145_abnormal_muscle_electrophysio1.20806069
80MP0004133_heterotaxia1.19582766
81MP0004858_abnormal_nervous_system1.16379462
82MP0000462_abnormal_digestive_system1.14905452
83MP0005551_abnormal_eye_electrophysiolog1.14572579
84MP0001188_hyperpigmentation1.13903929
85MP0003011_delayed_dark_adaptation1.12775182
86MP0008775_abnormal_heart_ventricle1.11980418
87MP0001529_abnormal_vocalization1.11879026
88MP0001346_abnormal_lacrimal_gland1.11308905
89MP0002972_abnormal_cardiac_muscle1.11051204
90MP0002067_abnormal_sensory_capabilities1.11048322
91MP0004043_abnormal_pH_regulation1.10310960
92MP0005330_cardiomyopathy1.09428531
93MP0002735_abnormal_chemical_nociception1.09366445
94MP0003718_maternal_effect1.08905377
95MP0002160_abnormal_reproductive_system1.08278609
96MP0000383_abnormal_hair_follicle1.06736189
97MP0001970_abnormal_pain_threshold1.06444265
98MP0002163_abnormal_gland_morphology1.05656468
99MP0003195_calcinosis1.05608290
100MP0002184_abnormal_innervation1.05467319
101MP0010234_abnormal_vibrissa_follicle1.05237801
102MP0005171_absent_coat_pigmentation1.04231554
103MP0002066_abnormal_motor_capabilities/c1.03164523
104MP0002822_catalepsy1.01415147
105MP0005620_abnormal_muscle_contractility1.00928598
106MP0001502_abnormal_circadian_rhythm1.00913623
107MP0001905_abnormal_dopamine_level1.00442109
108MP0000647_abnormal_sebaceous_gland1.00403362
109MP0008569_lethality_at_weaning0.99785817
110MP0003646_muscle_fatigue0.99565261
111MP0004130_abnormal_muscle_cell0.98705909
112MP0002653_abnormal_ependyma_morphology0.97389565
113MP0008058_abnormal_DNA_repair0.97108955
114MP0003631_nervous_system_phenotype0.96191246
115MP0001293_anophthalmia0.95719267
116MP0004142_abnormal_muscle_tone0.95380372
117MP0002254_reproductive_system_inflammat0.92740325
118MP0000747_muscle_weakness0.92349765
119MP0002557_abnormal_social/conspecific_i0.91025163
120MP0005379_endocrine/exocrine_gland_phen0.90974968
121MP0003633_abnormal_nervous_system0.90109975
122MP0003937_abnormal_limbs/digits/tail_de0.89413528
123MP0005365_abnormal_bile_salt0.89379495
124MP0001968_abnormal_touch/_nociception0.89236578
125MP0005389_reproductive_system_phenotype0.88580010
126MP0002909_abnormal_adrenal_gland0.88548543
127MP0004811_abnormal_neuron_physiology0.88534238
128MP0006138_congestive_heart_failure0.88230542
129MP0006054_spinal_hemorrhage0.87766837
130MP0002152_abnormal_brain_morphology0.87226255
131MP0001986_abnormal_taste_sensitivity0.87054226
132MP0002752_abnormal_somatic_nervous0.86652987
133MP0002796_impaired_skin_barrier0.86451632
134MP0008875_abnormal_xenobiotic_pharmacok0.86161521
135MP0004087_abnormal_muscle_fiber0.84837580
136MP0002282_abnormal_trachea_morphology0.84156698
137MP0005174_abnormal_tail_pigmentation0.83758198
138MP0003938_abnormal_ear_development0.83001816
139MP0003045_fibrosis0.82458881
140MP0005084_abnormal_gallbladder_morpholo0.82425975
141MP0001177_atelectasis0.82155440
142MP0005248_abnormal_Harderian_gland0.82027084
143MP0002090_abnormal_vision0.81791049
144MP0001501_abnormal_sleep_pattern0.80053419
145MP0005187_abnormal_penis_morphology0.76952657
146MP0006276_abnormal_autonomic_nervous0.76555338
147MP0004147_increased_porphyrin_level0.76372726
148MP0002118_abnormal_lipid_homeostasis0.76137327
149MP0003868_abnormal_feces_composition0.75213026
150MP0005195_abnormal_posterior_eye0.74265901

Predicted human phenotypes

RankGene SetZ-score
1Neurofibrillary tangles (HP:0002185)5.21049903
2Cerebral inclusion bodies (HP:0100314)4.25678787
3Degeneration of the lateral corticospinal tracts (HP:0002314)4.23144231
4Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.23144231
5Abnormality of the corticospinal tract (HP:0002492)4.16663090
6Sensory axonal neuropathy (HP:0003390)4.06768029
7Pancreatic cysts (HP:0001737)3.90156876
8Supranuclear gaze palsy (HP:0000605)3.61945742
9Pancreatic fibrosis (HP:0100732)3.54449197
10Pheochromocytoma (HP:0002666)3.42813848
11Abnormality of the renal cortex (HP:0011035)3.36377577
12Spastic gait (HP:0002064)3.29991026
13Abnormality of midbrain morphology (HP:0002418)3.28300484
14Molar tooth sign on MRI (HP:0002419)3.28300484
15Nephronophthisis (HP:0000090)3.26756674
16Renal cortical cysts (HP:0000803)3.26321926
17True hermaphroditism (HP:0010459)3.15398576
18Termporal pattern (HP:0011008)3.14863148
19Insidious onset (HP:0003587)3.14863148
20Akinesia (HP:0002304)3.12187087
21Hyporeflexia of lower limbs (HP:0002600)3.09586291
22Intention tremor (HP:0002080)3.05959599
23Medial flaring of the eyebrow (HP:0010747)3.01379425
24Intestinal atresia (HP:0011100)2.93799609
25Intrahepatic cholestasis (HP:0001406)2.93607258
26Myokymia (HP:0002411)2.87487911
27Abnormality of the renal medulla (HP:0100957)2.87159891
28Dysmetria (HP:0001310)2.82504570
29Volvulus (HP:0002580)2.78268143
30Sudden death (HP:0001699)2.77430691
31Pendular nystagmus (HP:0012043)2.74100836
32Lower limb muscle weakness (HP:0007340)2.73587138
33Neuroendocrine neoplasm (HP:0100634)2.73129845
34Parakeratosis (HP:0001036)2.72848581
35Genital tract atresia (HP:0001827)2.70890430
36Congenital stationary night blindness (HP:0007642)2.69238082
37Onion bulb formation (HP:0003383)2.68616213
38Ankle clonus (HP:0011448)2.60053693
39Methylmalonic acidemia (HP:0002912)2.59692054
40Abolished electroretinogram (ERG) (HP:0000550)2.56334967
41Vaginal atresia (HP:0000148)2.55783201
42Gait imbalance (HP:0002141)2.55173531
43Hypothermia (HP:0002045)2.50462514
44Nephrogenic diabetes insipidus (HP:0009806)2.47122836
45Aplasia involving bones of the extremities (HP:0009825)2.46678867
46Aplasia involving bones of the upper limbs (HP:0009823)2.46678867
47Aplasia of the phalanges of the hand (HP:0009802)2.46678867
48Megalencephaly (HP:0001355)2.46174481
49Gaze-evoked nystagmus (HP:0000640)2.45078599
50Epileptic encephalopathy (HP:0200134)2.38998320
51Atonic seizures (HP:0010819)2.36147719
52Deep venous thrombosis (HP:0002625)2.35820332
53Congenital primary aphakia (HP:0007707)2.35087394
54Febrile seizures (HP:0002373)2.34155491
55Abnormal auditory evoked potentials (HP:0006958)2.32254825
56Macroorchidism (HP:0000053)2.30231000
57Alacrima (HP:0000522)2.30192650
58Tubular atrophy (HP:0000092)2.29952136
59Lissencephaly (HP:0001339)2.29523043
60Oligodactyly (hands) (HP:0001180)2.29334553
61Broad-based gait (HP:0002136)2.26902784
62Abnormality of the labia minora (HP:0012880)2.26192179
63Urinary bladder sphincter dysfunction (HP:0002839)2.21473244
64Aplasia/Hypoplasia of the tongue (HP:0010295)2.21460672
65Generalized myoclonic seizures (HP:0002123)2.21418765
66Peripheral hypomyelination (HP:0007182)2.20744790
67Cystic liver disease (HP:0006706)2.20538381
68Excessive salivation (HP:0003781)2.20297367
69Drooling (HP:0002307)2.20297367
70Aplasia/Hypoplasia of the tibia (HP:0005772)2.19683871
71Hyperventilation (HP:0002883)2.19302037
72Anophthalmia (HP:0000528)2.19051111
73Thickened helices (HP:0000391)2.18684632
74Morphological abnormality of the pyramidal tract (HP:0002062)2.17189775
75Morphological abnormality of the middle ear (HP:0008609)2.17071532
76Hamartoma of the eye (HP:0010568)2.16239985
77Focal seizures (HP:0007359)2.15577348
78Syncope (HP:0001279)2.14916504
79Difficulty running (HP:0009046)2.14612479
80Action tremor (HP:0002345)2.13837542
81Bilateral microphthalmos (HP:0007633)2.13426233
82Chronic hepatic failure (HP:0100626)2.11753755
83Epidermoid cyst (HP:0200040)2.10323797
84Optic nerve hypoplasia (HP:0000609)2.09927223
85Dysdiadochokinesis (HP:0002075)2.09010849
86Hypsarrhythmia (HP:0002521)2.08981674
87Cerebral hemorrhage (HP:0001342)2.08903737
88Methylmalonic aciduria (HP:0012120)2.07271531
89Attenuation of retinal blood vessels (HP:0007843)2.06825524
90EEG with generalized epileptiform discharges (HP:0011198)2.06812204
91Atrial fibrillation (HP:0005110)2.06067901
92Scanning speech (HP:0002168)2.05343086
93Agitation (HP:0000713)2.05205640
94Aplasia/Hypoplasia of the spleen (HP:0010451)2.04971269
95Muscle hypertrophy of the lower extremities (HP:0008968)2.03860969
96Bifid tongue (HP:0010297)2.03780798
97Prolonged QT interval (HP:0001657)2.03518978
98Muscle fiber splitting (HP:0003555)2.02489997
99Bony spicule pigmentary retinopathy (HP:0007737)2.01673152
100Right ventricular cardiomyopathy (HP:0011663)2.00596211
101Pachygyria (HP:0001302)2.00493361
102Keratoconus (HP:0000563)2.00409372
103Increased corneal curvature (HP:0100692)2.00409372
104Sclerocornea (HP:0000647)1.98771307
105Type II lissencephaly (HP:0007260)1.98531550
106Asplenia (HP:0001746)1.98524132
107Coronal craniosynostosis (HP:0004440)1.98256707
108Focal motor seizures (HP:0011153)1.97824013
109Short tibia (HP:0005736)1.97450315
110Epileptiform EEG discharges (HP:0011182)1.97414562
111Neoplasm of the adrenal cortex (HP:0100641)1.96281744
112Furrowed tongue (HP:0000221)1.96019163
113Relative macrocephaly (HP:0004482)1.95761377
114Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.94965791
115Polyphagia (HP:0002591)1.94342934
116Renal hypoplasia (HP:0000089)1.94311180
117Chorioretinal atrophy (HP:0000533)1.92720347
118Progressive inability to walk (HP:0002505)1.91482273
119Limb dystonia (HP:0002451)1.91386750
120Infantile muscular hypotonia (HP:0008947)1.91241964
121Decreased motor nerve conduction velocity (HP:0003431)1.90713837
122Primary atrial arrhythmia (HP:0001692)1.90588913
123Aplasia/Hypoplasia of the sternum (HP:0006714)1.90276524
124Anencephaly (HP:0002323)1.89233587
125Abnormal rod and cone electroretinograms (HP:0008323)1.87832794
126Small hand (HP:0200055)1.87557967
127Large for gestational age (HP:0001520)1.87252317
128Spastic tetraparesis (HP:0001285)1.85643796
129Hemiparesis (HP:0001269)1.84767972
130Abnormality of aromatic amino acid family metabolism (HP:0004338)1.84142727
131Hyperinsulinemic hypoglycemia (HP:0000825)1.84013776
132Decreased lacrimation (HP:0000633)1.83677852
133Specific learning disability (HP:0001328)1.83240151
134Abnormality of the parathyroid morphology (HP:0011766)1.83061245
135Blue irides (HP:0000635)1.82953554
136Hammertoe (HP:0001765)1.82595372
137Slow saccadic eye movements (HP:0000514)1.82414986
138Inability to walk (HP:0002540)1.81432024
139Postaxial foot polydactyly (HP:0001830)1.81390172
140Anteriorly placed anus (HP:0001545)1.80987368
141Postaxial hand polydactyly (HP:0001162)1.80158028
142Ketoacidosis (HP:0001993)1.79377266
143Hyperlipoproteinemia (HP:0010980)1.79145210
144Clonus (HP:0002169)1.79071530
1453-Methylglutaconic aciduria (HP:0003535)1.77975920
146Aplasia/Hypoplasia of the fovea (HP:0008060)1.77246634
147Hypoplasia of the fovea (HP:0007750)1.77246634
148Abnormal drinking behavior (HP:0030082)1.76723337
149Polydipsia (HP:0001959)1.76723337
150Congenital hepatic fibrosis (HP:0002612)1.75378332
151Aqueductal stenosis (HP:0002410)1.74885643
152Progressive cerebellar ataxia (HP:0002073)1.74834836
153Spastic paraplegia (HP:0001258)1.74653421
154Bronchomalacia (HP:0002780)1.74071701
155Steppage gait (HP:0003376)1.72728134
156Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.72658379
157Narrow forehead (HP:0000341)1.72271344
158Generalized tonic-clonic seizures (HP:0002069)1.71912148
159Hypoglycemic seizures (HP:0002173)1.71749651
160Diminished movement (HP:0002374)1.70259265
161Paraparesis (HP:0002385)1.69322544
162Exercise-induced myalgia (HP:0003738)1.69206384
163Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.69050730
164Short 1st metacarpal (HP:0010034)1.69050730
165Postural instability (HP:0002172)1.68810968
166Clumsiness (HP:0002312)1.68197586
167Foot dorsiflexor weakness (HP:0009027)1.67866825
168Dynein arm defect of respiratory motile cilia (HP:0012255)1.67811952
169Absent/shortened dynein arms (HP:0200106)1.67811952
170Abnormality of vitamin B metabolism (HP:0004340)1.67747374
171Preaxial hand polydactyly (HP:0001177)1.67489908
172Hyperglycinemia (HP:0002154)1.67111118
173Thyroid-stimulating hormone excess (HP:0002925)1.66880906
174Congenital sensorineural hearing impairment (HP:0008527)1.66878922
175Calf muscle hypertrophy (HP:0008981)1.66730738
176Congenital, generalized hypertrichosis (HP:0004540)1.66032532
177Supraventricular tachycardia (HP:0004755)1.65927924
178Cutaneous finger syndactyly (HP:0010554)1.65581213
179Progressive macrocephaly (HP:0004481)1.65472953
180Distal sensory impairment (HP:0002936)1.65399082
181Gastrointestinal atresia (HP:0002589)1.65315068
182Genetic anticipation (HP:0003743)1.64461302
183Decreased circulating renin level (HP:0003351)1.64456692
184Labial hypoplasia (HP:0000066)1.64295308
185Supraventricular arrhythmia (HP:0005115)1.63142063
186Decreased central vision (HP:0007663)1.63102239
187Urinary urgency (HP:0000012)1.62639441
188Impaired vibration sensation in the lower limbs (HP:0002166)1.62636010
189Abnormality of the foot musculature (HP:0001436)1.61097693
190Paraplegia (HP:0010550)1.60939520

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.14750303
2PRPF4B3.93495891
3MARK13.71354196
4STK393.55035677
5WNK33.15488239
6TRIM282.84672442
7LATS12.84033993
8MAP4K22.52056084
9OXSR12.35440316
10BCR2.12642895
11GRK12.11698877
12PKN12.07777294
13ACVR1B2.02534289
14PHKG12.00522695
15PHKG22.00522695
16PAK61.90586128
17MET1.87931332
18NTRK11.83819142
19ADRBK21.83034803
20FGFR21.80352507
21PAK31.79011093
22ERBB31.70679142
23EPHB11.70614687
24ICK1.67180146
25EPHA41.64066337
26WNK11.55305746
27WNK41.53952833
28MAP3K91.50108526
29PLK21.42697178
30NTRK21.42572023
31PINK11.42245099
32ERBB41.39974439
33MKNK21.37098345
34INSRR1.35771967
35STK161.34936488
36CSNK1G21.32935846
37EIF2AK31.31852635
38CSNK1A1L1.30046834
39UHMK11.28228016
40CASK1.27688654
41MAP3K41.23543670
42CSNK1G31.22619759
43NTRK31.20535665
44ZAK1.19399811
45DYRK21.16795274
46LIMK11.13347049
47TNIK1.08982559
48SGK2231.08288773
49SGK4941.08288773
50NEK61.07755890
51CSNK1G11.07100817
52MST41.05756549
53NUAK11.05266028
54MARK21.04935415
55ROCK21.03786347
56TYRO31.03287621
57CDK51.03216430
58PLK31.02300954
59LATS21.01200740
60PRKCG1.00867398
61CAMK2D0.98341894
62MAP3K20.95597953
63CAMK2B0.94842053
64PLK40.94097635
65CAMK2A0.92477952
66PNCK0.92367225
67PIK3CA0.90000510
68EPHB20.89622153
69MAPK130.86689289
70CAMK1G0.84697501
71KSR20.83922152
72RET0.83823431
73PRKCE0.81931585
74FGR0.81770162
75MINK10.80901355
76DMPK0.80899231
77BRSK20.80465129
78TRPM70.78727205
79PRKCH0.77899064
80CAMKK20.77766810
81TGFBR10.77709788
82STK110.75676734
83ROCK10.74300897
84LMTK20.73237820
85KSR10.71741855
86CDC42BPA0.71526840
87SIK10.68933038
88TLK10.68929454
89ADRBK10.67980898
90TIE10.67365967
91CDK190.67165323
92SRPK10.66825873
93CAMK2G0.66616497
94MKNK10.65875768
95PRKD10.65701844
96MAP2K40.65597551
97VRK10.64638614
98OBSCN0.62372120
99CDK140.62335581
100MAP2K70.61597094
101PDPK10.61382753
102MAPK150.60442268
103FER0.60089349
104HIPK20.59855530
105CCNB10.59023029
106DAPK20.58734619
107SGK10.58488799
108STK38L0.58100477
109PRKD30.57446422
110PDGFRB0.57332177
111STK30.57302360
112CSNK1D0.56002472
113DYRK30.55501929
114DYRK1A0.55017893
115ERBB20.54825623
116DDR20.54073148
117GRK50.53927074
118BMPR1B0.53865129
119WEE10.52480662
120PRKAA10.52425915
121PRKG10.52386633
122PRKCZ0.52145850
123PLK10.51668106
124CDK150.51611372
125MAPKAPK50.50913110
126PTK20.49995180
127PRKCQ0.49090910
128SIK30.48355133
129TEC0.48326044
130CDK180.48326026
131FYN0.48271267
132MUSK0.47292668
133CSNK1A10.46736274
134GSK3A0.46231713
135SGK20.45398705
136SGK30.44290229
137EPHA30.43971382
138TAOK30.43965245
139FLT30.43933818
140PRKACA0.41351043
141MAP3K70.40735236
142ABL10.38903143
143BCKDK0.37891779
144PTK2B0.37714623
145NLK0.37468808
146ATM0.36825108
147PRKCI0.36321803
148MAP2K60.35104478
149NME10.34931265
150AKT30.33949892
151CSNK1E0.32356711
152PRKACB0.32056241
153CAMK10.31617136
154CDK30.29719750

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030602.54190573
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.40422869
3Nitrogen metabolism_Homo sapiens_hsa009102.14692072
4Steroid biosynthesis_Homo sapiens_hsa001002.03341706
5Butanoate metabolism_Homo sapiens_hsa006501.94376708
6Fatty acid elongation_Homo sapiens_hsa000621.90175256
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.83645687
8Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.82420587
9Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.82354404
10RNA degradation_Homo sapiens_hsa030181.71058781
11Axon guidance_Homo sapiens_hsa043601.68028213
12GABAergic synapse_Homo sapiens_hsa047271.62060042
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.55756380
14Basal transcription factors_Homo sapiens_hsa030221.49146982
15Oxidative phosphorylation_Homo sapiens_hsa001901.44137824
16Glutamatergic synapse_Homo sapiens_hsa047241.40335223
17Dorso-ventral axis formation_Homo sapiens_hsa043201.40002658
18Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.38907582
19Fanconi anemia pathway_Homo sapiens_hsa034601.38731333
20Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.37925149
21Sulfur metabolism_Homo sapiens_hsa009201.37850062
22Selenocompound metabolism_Homo sapiens_hsa004501.36149554
23Caffeine metabolism_Homo sapiens_hsa002321.33295387
24Primary bile acid biosynthesis_Homo sapiens_hsa001201.29710840
25Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.26931082
26Ether lipid metabolism_Homo sapiens_hsa005651.22590440
27Nicotine addiction_Homo sapiens_hsa050331.20043442
28Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.19992711
29Homologous recombination_Homo sapiens_hsa034401.17793200
30Parkinsons disease_Homo sapiens_hsa050121.17672679
31Morphine addiction_Homo sapiens_hsa050321.16711505
32Regulation of autophagy_Homo sapiens_hsa041401.16491247
33Fatty acid metabolism_Homo sapiens_hsa012121.16309678
34Circadian entrainment_Homo sapiens_hsa047131.15844270
35Serotonergic synapse_Homo sapiens_hsa047261.14631893
36Collecting duct acid secretion_Homo sapiens_hsa049661.14405022
37Dilated cardiomyopathy_Homo sapiens_hsa054141.13207680
38Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.11988390
39Histidine metabolism_Homo sapiens_hsa003401.10677676
40Cocaine addiction_Homo sapiens_hsa050301.10606552
41Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.10243214
42Insulin secretion_Homo sapiens_hsa049111.09041459
43Bile secretion_Homo sapiens_hsa049761.07874737
44Circadian rhythm_Homo sapiens_hsa047101.07688192
45Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.07063137
46Arginine biosynthesis_Homo sapiens_hsa002201.06875947
47Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.06574169
48Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.06092384
49Type II diabetes mellitus_Homo sapiens_hsa049301.02434656
50Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.02237964
51Tryptophan metabolism_Homo sapiens_hsa003800.99628454
52Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.99616655
53Cholinergic synapse_Homo sapiens_hsa047250.99267407
54Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.99232364
55Fatty acid degradation_Homo sapiens_hsa000710.98786412
56Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.97619514
57Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.97436211
58Salivary secretion_Homo sapiens_hsa049700.97358293
59Renal cell carcinoma_Homo sapiens_hsa052110.96973738
60Dopaminergic synapse_Homo sapiens_hsa047280.96959232
61Ovarian steroidogenesis_Homo sapiens_hsa049130.95847120
62Maturity onset diabetes of the young_Homo sapiens_hsa049500.95233952
63Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.94471097
64ErbB signaling pathway_Homo sapiens_hsa040120.92792140
65Cardiac muscle contraction_Homo sapiens_hsa042600.92408304
66Non-homologous end-joining_Homo sapiens_hsa034500.91284912
67Tight junction_Homo sapiens_hsa045300.90285477
68Taste transduction_Homo sapiens_hsa047420.89271658
69Synaptic vesicle cycle_Homo sapiens_hsa047210.89117676
70Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.88559492
71Propanoate metabolism_Homo sapiens_hsa006400.88273461
72Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.85258612
73Long-term depression_Homo sapiens_hsa047300.85236004
74Gastric acid secretion_Homo sapiens_hsa049710.84309923
75Retinol metabolism_Homo sapiens_hsa008300.84029945
76Amphetamine addiction_Homo sapiens_hsa050310.84018249
77Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.83858931
78Oocyte meiosis_Homo sapiens_hsa041140.82114180
79Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.81996488
80ABC transporters_Homo sapiens_hsa020100.81966032
81Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.81630246
82Renin secretion_Homo sapiens_hsa049240.81182475
83Fatty acid biosynthesis_Homo sapiens_hsa000610.80368978
84Vascular smooth muscle contraction_Homo sapiens_hsa042700.78904068
85Glycerolipid metabolism_Homo sapiens_hsa005610.77635764
86PPAR signaling pathway_Homo sapiens_hsa033200.77231865
87Olfactory transduction_Homo sapiens_hsa047400.76925218
88Chemical carcinogenesis_Homo sapiens_hsa052040.76925144
89Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.76702714
90Gap junction_Homo sapiens_hsa045400.74881354
91Long-term potentiation_Homo sapiens_hsa047200.74092724
92Huntingtons disease_Homo sapiens_hsa050160.74024537
93Alzheimers disease_Homo sapiens_hsa050100.72333454
94Phospholipase D signaling pathway_Homo sapiens_hsa040720.71562037
95Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.71079794
96alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.70880908
97cAMP signaling pathway_Homo sapiens_hsa040240.70436063
98Complement and coagulation cascades_Homo sapiens_hsa046100.68399267
99Melanogenesis_Homo sapiens_hsa049160.68011055
100beta-Alanine metabolism_Homo sapiens_hsa004100.67025004
101Ras signaling pathway_Homo sapiens_hsa040140.66900168
102Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.66322116
103Oxytocin signaling pathway_Homo sapiens_hsa049210.66083663
104Linoleic acid metabolism_Homo sapiens_hsa005910.64846435
105GnRH signaling pathway_Homo sapiens_hsa049120.63824981
106Sphingolipid metabolism_Homo sapiens_hsa006000.63525111
107Aldosterone synthesis and secretion_Homo sapiens_hsa049250.62642442
108Vitamin B6 metabolism_Homo sapiens_hsa007500.62559837
109Estrogen signaling pathway_Homo sapiens_hsa049150.61162195
110Tyrosine metabolism_Homo sapiens_hsa003500.59417405
111Steroid hormone biosynthesis_Homo sapiens_hsa001400.59315890
112Basal cell carcinoma_Homo sapiens_hsa052170.58318463
113RNA polymerase_Homo sapiens_hsa030200.56938023
114Peroxisome_Homo sapiens_hsa041460.54937708
115Hedgehog signaling pathway_Homo sapiens_hsa043400.53840084
116cGMP-PKG signaling pathway_Homo sapiens_hsa040220.53766376
117Prion diseases_Homo sapiens_hsa050200.53566509
118Calcium signaling pathway_Homo sapiens_hsa040200.52809303
119Phenylalanine metabolism_Homo sapiens_hsa003600.52582143
120Hippo signaling pathway_Homo sapiens_hsa043900.51370714
121Fat digestion and absorption_Homo sapiens_hsa049750.51188167
122Pancreatic secretion_Homo sapiens_hsa049720.50370584
123Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50052566
124Phototransduction_Homo sapiens_hsa047440.50017353
125Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.49757341
126Choline metabolism in cancer_Homo sapiens_hsa052310.49630484
127Phosphatidylinositol signaling system_Homo sapiens_hsa040700.48956621
128p53 signaling pathway_Homo sapiens_hsa041150.48777225
129Endocytosis_Homo sapiens_hsa041440.47991177
130Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.45868939
131Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.45840095
132Sphingolipid signaling pathway_Homo sapiens_hsa040710.45632553
133Arginine and proline metabolism_Homo sapiens_hsa003300.45631245
134Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.45492449
135Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44780764
136TGF-beta signaling pathway_Homo sapiens_hsa043500.44655756
137Metabolic pathways_Homo sapiens_hsa011000.44571981
138Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.42571980
139Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.41845891
140Purine metabolism_Homo sapiens_hsa002300.41834265
141Arachidonic acid metabolism_Homo sapiens_hsa005900.35362358

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