DAAM2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)5.28199485
2central nervous system myelination (GO:0022010)5.28199485
3gonadal mesoderm development (GO:0007506)4.35699987
4postsynaptic membrane organization (GO:0001941)4.27889844
5locomotory exploration behavior (GO:0035641)4.11039893
6L-amino acid import (GO:0043092)4.07497236
7sodium ion export (GO:0071436)4.04129791
8cellular potassium ion homeostasis (GO:0030007)3.90561475
9astrocyte development (GO:0014002)3.82877446
10myelination (GO:0042552)3.66432715
11synaptic vesicle maturation (GO:0016188)3.66301012
12ensheathment of neurons (GO:0007272)3.61390666
13axon ensheathment (GO:0008366)3.61390666
14regulation of short-term neuronal synaptic plasticity (GO:0048172)3.60512636
15myelination in peripheral nervous system (GO:0022011)3.50826854
16peripheral nervous system axon ensheathment (GO:0032292)3.50826854
17layer formation in cerebral cortex (GO:0021819)3.42954780
18potassium ion import (GO:0010107)3.40569001
19cGMP-mediated signaling (GO:0019934)3.35787219
20neurotransmitter uptake (GO:0001504)3.35009449
21presynaptic membrane assembly (GO:0097105)3.33416798
22presynaptic membrane organization (GO:0097090)3.33155291
23positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.32539695
24positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.32524898
25astrocyte differentiation (GO:0048708)3.31916739
26glomerular basement membrane development (GO:0032836)3.28644492
27amino acid import (GO:0043090)3.28351953
28ovulation cycle (GO:0042698)3.15742474
29myelin maintenance (GO:0043217)3.14115045
30positive regulation of male gonad development (GO:2000020)3.12616307
31establishment of nucleus localization (GO:0040023)3.11535498
32potassium ion homeostasis (GO:0055075)3.09461458
33acidic amino acid transport (GO:0015800)3.05933503
34gamma-aminobutyric acid transport (GO:0015812)3.03550978
35synaptic vesicle docking involved in exocytosis (GO:0016081)3.03186067
36neuronal action potential propagation (GO:0019227)3.02867140
37positive regulation of synapse maturation (GO:0090129)2.98150754
38activation of protein kinase A activity (GO:0034199)2.93988845
39neuronal ion channel clustering (GO:0045161)2.93825581
40glycine transport (GO:0015816)2.93814040
41cellular sodium ion homeostasis (GO:0006883)2.92935152
42regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.92679366
43dermatan sulfate biosynthetic process (GO:0030208)2.91229117
44auditory behavior (GO:0031223)2.89670144
45ionotropic glutamate receptor signaling pathway (GO:0035235)2.89177270
46cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.89136903
47membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.88228533
48regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.85857422
49regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.85789456
50sex determination (GO:0007530)2.85714421
51dendrite morphogenesis (GO:0048813)2.83898870
52positive regulation of dendritic spine development (GO:0060999)2.83838000
53cell communication by electrical coupling (GO:0010644)2.83223214
54regulation of neuronal synaptic plasticity (GO:0048168)2.82719578
55positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.82397013
56regulation of synaptic vesicle exocytosis (GO:2000300)2.81479855
57glutamate secretion (GO:0014047)2.79515015
58neuromuscular process controlling balance (GO:0050885)2.79418654
59membrane assembly (GO:0071709)2.78609963
60chondroitin sulfate catabolic process (GO:0030207)2.78047261
61vocalization behavior (GO:0071625)2.77833376
62dermatan sulfate metabolic process (GO:0030205)2.77622182
63synaptic vesicle exocytosis (GO:0016079)2.77267579
64cytoskeletal anchoring at plasma membrane (GO:0007016)2.76520230
65peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.74868730
66dendritic spine morphogenesis (GO:0060997)2.73332746
67regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.73088651
68regulation of female receptivity (GO:0045924)2.72690525
69one-carbon compound transport (GO:0019755)2.71689035
70cerebellar granule cell differentiation (GO:0021707)2.71007335
71long-term synaptic potentiation (GO:0060291)2.70378852
72L-glutamate transport (GO:0015813)2.70243771
73exploration behavior (GO:0035640)2.65801850
74response to auditory stimulus (GO:0010996)2.65614367
75neurotransmitter transport (GO:0006836)2.65510625
76peptidyl-tyrosine autophosphorylation (GO:0038083)2.65196977
77positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.64169856
78negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.62162123
79regulation of synapse structural plasticity (GO:0051823)2.61800003
80relaxation of smooth muscle (GO:0044557)2.59517053
81negative regulation of protein localization to cell surface (GO:2000009)2.59463259
82positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.58267585
83synaptic transmission, glutamatergic (GO:0035249)2.58171876
84regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.56938395
85cell communication involved in cardiac conduction (GO:0086065)2.56529383
86regulation of male gonad development (GO:2000018)2.55335026
87regulation of long-term neuronal synaptic plasticity (GO:0048169)2.54995722
88sex differentiation (GO:0007548)2.54517718
89transmission of nerve impulse (GO:0019226)2.54177149
90positive regulation of potassium ion transport (GO:0043268)2.53536414
91glutamate receptor signaling pathway (GO:0007215)2.51037837
92regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.50358681
93neurotransmitter secretion (GO:0007269)2.49914694
94regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.49764316
95regulation of synapse maturation (GO:0090128)2.49621347
96peripheral nervous system development (GO:0007422)2.49512710
97cyclic-nucleotide-mediated signaling (GO:0019935)2.49433748
98gamma-aminobutyric acid signaling pathway (GO:0007214)2.49433006
99regulation of neurotransmitter secretion (GO:0046928)2.49215437
100membrane hyperpolarization (GO:0060081)2.48834716
101long-chain fatty acid biosynthetic process (GO:0042759)2.48590103
102regulation of neurotransmitter transport (GO:0051588)2.48460047
103regulation of glutamate receptor signaling pathway (GO:1900449)2.48145461
104regulation of neurotransmitter levels (GO:0001505)2.47978114
105positive regulation of dendrite development (GO:1900006)2.47868305
106response to gravity (GO:0009629)2.46882335
107adenosine receptor signaling pathway (GO:0001973)2.46541181
108positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.46266440
109membrane depolarization during action potential (GO:0086010)2.44489358
110regulation of excitatory postsynaptic membrane potential (GO:0060079)2.44115891
111membrane repolarization (GO:0086009)2.44044125
112neuromuscular junction development (GO:0007528)2.43802811
113oligodendrocyte differentiation (GO:0048709)2.43769066
114regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.43563223
115synaptic vesicle endocytosis (GO:0048488)2.43453833
116negative regulation of synaptic transmission, GABAergic (GO:0032229)2.40785121
117stress fiber assembly (GO:0043149)2.40730652
118cellular response to cholesterol (GO:0071397)2.40527180
119regulation of neurotransmitter uptake (GO:0051580)2.39908031
120regulation of dendritic spine morphogenesis (GO:0061001)2.39076188
121long-term memory (GO:0007616)2.38807882
122C4-dicarboxylate transport (GO:0015740)2.37653249
123regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.37650685
124neuron-neuron synaptic transmission (GO:0007270)2.37171099
125neuron cell-cell adhesion (GO:0007158)2.37136577
126neuron recognition (GO:0008038)2.35017758
127neuromuscular process controlling posture (GO:0050884)2.34583429
128axonal fasciculation (GO:0007413)2.34160016
129lateral sprouting from an epithelium (GO:0060601)2.33855624
130regulation of voltage-gated calcium channel activity (GO:1901385)2.32811304
131regulation of synaptic vesicle transport (GO:1902803)2.32487616
132cerebellar Purkinje cell differentiation (GO:0021702)2.32408172
133asymmetric protein localization (GO:0008105)2.32035271
134neuroblast proliferation (GO:0007405)2.30396822
135protein localization to synapse (GO:0035418)2.30344753
136negative regulation of neurotransmitter transport (GO:0051589)2.29262702
137adult walking behavior (GO:0007628)2.28792383
138neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.28368386
139neurotransmitter-gated ion channel clustering (GO:0072578)2.28174378
140positive regulation of potassium ion transmembrane transport (GO:1901381)2.26056650
141regulation of ARF protein signal transduction (GO:0032012)2.25564938
142regulation of synaptic plasticity (GO:0048167)2.24684423

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.83962599
2* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.71722768
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.63003484
4EZH2_18974828_ChIP-Seq_MESCs_Mouse2.60753556
5RNF2_18974828_ChIP-Seq_MESCs_Mouse2.60753556
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.57450680
7DROSHA_22980978_ChIP-Seq_HELA_Human2.42133487
8* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.40400100
9SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.32732347
10GBX2_23144817_ChIP-Seq_PC3_Human2.28683573
11* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.28264135
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.27557307
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.27528526
14RNF2_27304074_Chip-Seq_ESCs_Mouse2.21040574
15IKZF1_21737484_ChIP-ChIP_HCT116_Human2.18886802
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.16902408
17* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.16269390
18* EED_16625203_ChIP-ChIP_MESCs_Mouse2.14238317
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.01934622
20EZH2_27294783_Chip-Seq_ESCs_Mouse1.98421241
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.89241826
22RARB_27405468_Chip-Seq_BRAIN_Mouse1.88337490
23STAT6_21828071_ChIP-Seq_BEAS2B_Human1.82243557
24EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.77057816
25ERG_21242973_ChIP-ChIP_JURKAT_Human1.74158688
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.71922224
27AR_21572438_ChIP-Seq_LNCaP_Human1.70815484
28MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.68147971
29* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.65626480
30CDX2_19796622_ChIP-Seq_MESCs_Mouse1.58865279
31* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.56703379
32ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.52470881
33* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.49698240
34REST_21632747_ChIP-Seq_MESCs_Mouse1.46151252
35PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.43727907
36KDM2B_26808549_Chip-Seq_K562_Human1.41338855
37TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.39442970
38EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.38949370
39RING1B_27294783_Chip-Seq_ESCs_Mouse1.37446478
40PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.32878054
41EP300_21415370_ChIP-Seq_HL-1_Mouse1.30820222
42RARG_19884340_ChIP-ChIP_MEFs_Mouse1.30224188
43ZNF217_24962896_ChIP-Seq_MCF-7_Human1.29875368
44SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28580559
45VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.25613157
46SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23732820
47RING1B_27294783_Chip-Seq_NPCs_Mouse1.22929785
48SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.22464047
49REST_18959480_ChIP-ChIP_MESCs_Mouse1.19134673
50ARNT_22903824_ChIP-Seq_MCF-7_Human1.18478144
51AHR_22903824_ChIP-Seq_MCF-7_Human1.17414429
52ESR2_21235772_ChIP-Seq_MCF-7_Human1.17136195
53CBX2_27304074_Chip-Seq_ESCs_Mouse1.16864062
54TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.15951505
55TP53_16413492_ChIP-PET_HCT116_Human1.15269767
56SMAD4_21799915_ChIP-Seq_A2780_Human1.14031726
57SMAD_19615063_ChIP-ChIP_OVARY_Human1.13988058
58ZFP281_18757296_ChIP-ChIP_E14_Mouse1.13660768
59AR_19668381_ChIP-Seq_PC3_Human1.12814846
60PIAS1_25552417_ChIP-Seq_VCAP_Human1.11415405
61NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.10507100
62SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09849859
63SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.09723933
64CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.09623243
65STAT3_23295773_ChIP-Seq_U87_Human1.09161610
66PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.08983496
67SOX2_21211035_ChIP-Seq_LN229_Gbm1.08892425
68TBX20_22080862_ChIP-Seq_HEART_Mouse1.08573049
69TBX20_22328084_ChIP-Seq_HEART_Mouse1.08573049
70OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08452076
71RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.08343150
72* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.05998988
73DNAJC2_21179169_ChIP-ChIP_NT2_Human1.04673442
74TRIM28_21343339_ChIP-Seq_HEK293_Human1.04624466
75* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.03875654
76SMAD3_21741376_ChIP-Seq_EPCs_Human1.03686120
77TP53_23651856_ChIP-Seq_MEFs_Mouse1.03241793
78PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.03034469
79NR3C1_23031785_ChIP-Seq_PC12_Mouse1.02305454
80RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.01782186
81CTBP2_25329375_ChIP-Seq_LNCAP_Human1.01274601
82NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00253017
83ZFP281_27345836_Chip-Seq_ESCs_Mouse0.99143116
84* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.98827068
85MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98669206
86SMAD4_21741376_ChIP-Seq_HESCs_Human0.98233784
87CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.97395479
88TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96979941
89* LXR_22292898_ChIP-Seq_THP-1_Human0.96335329
90CTBP1_25329375_ChIP-Seq_LNCAP_Human0.96068649
91CTCF_27219007_Chip-Seq_Bcells_Human0.95646809
92YAP1_20516196_ChIP-Seq_MESCs_Mouse0.95294954
93SMAD3_21741376_ChIP-Seq_ESCs_Human0.95248099
94ISL1_27105846_Chip-Seq_CPCs_Mouse0.94561418
95BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.94421166
96SMAD3_21741376_ChIP-Seq_HESCs_Human0.94392980
97TCF4_23295773_ChIP-Seq_U87_Human0.92081257
98THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.91400974
99TP53_20018659_ChIP-ChIP_R1E_Mouse0.91140323
100TET1_21490601_ChIP-Seq_MESCs_Mouse0.90461217
101* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.90276214
102TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.89882078
103NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.89873238
104KDM2B_26808549_Chip-Seq_SUP-B15_Human0.88423994
105SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.88228149
106GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87811159
107ESR1_20079471_ChIP-ChIP_T-47D_Human0.87737733
108OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.87423783
109TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87224481
110PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.85818135
111TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.85065549
112* FOXA2_19822575_ChIP-Seq_HepG2_Human0.83659856
113P53_22127205_ChIP-Seq_FIBROBLAST_Human0.83078410
114SMAD4_21741376_ChIP-Seq_EPCs_Human0.82994704
115GATA1_26923725_Chip-Seq_HPCs_Mouse0.80992214
116CLOCK_20551151_ChIP-Seq_293T_Human0.80344741
117PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.80239913
118SOX9_24532713_ChIP-Seq_HFSC_Mouse0.79526940
119* NFIB_24661679_ChIP-Seq_LUNG_Mouse0.79238300

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.33754700
2MP0005377_hearing/vestibular/ear_phenot2.83784434
3MP0003878_abnormal_ear_physiology2.83784434
4MP0004885_abnormal_endolymph2.75554484
5MP0003635_abnormal_synaptic_transmissio2.70452126
6MP0003690_abnormal_glial_cell2.54373636
7MP0004270_analgesia2.53491227
8MP0001486_abnormal_startle_reflex2.43326296
9MP0003880_abnormal_central_pattern2.42721773
10MP0005623_abnormal_meninges_morphology2.37372223
11MP0009780_abnormal_chondrocyte_physiolo2.36981082
12MP0000920_abnormal_myelination2.29600105
13MP0009046_muscle_twitch2.24193882
14MP0002064_seizures2.20700567
15MP0002272_abnormal_nervous_system2.17545019
16MP0003329_amyloid_beta_deposits2.09774869
17MP0009745_abnormal_behavioral_response2.06828051
18MP0002063_abnormal_learning/memory/cond2.01183926
19MP0005423_abnormal_somatic_nervous1.94529837
20MP0008995_early_reproductive_senescence1.89790306
21MP0001440_abnormal_grooming_behavior1.84466919
22MP0000751_myopathy1.82368206
23MP0002572_abnormal_emotion/affect_behav1.77968306
24MP0008569_lethality_at_weaning1.73652187
25MP0001485_abnormal_pinna_reflex1.72194779
26MP0004858_abnormal_nervous_system1.71157912
27MP0003705_abnormal_hypodermis_morpholog1.70935489
28MP0000778_abnormal_nervous_system1.67711330
29MP0003879_abnormal_hair_cell1.67090374
30MP0004742_abnormal_vestibular_system1.65496988
31MP0001299_abnormal_eye_distance/1.64475427
32MP0004272_abnormal_basement_membrane1.63473005
33MP0005167_abnormal_blood-brain_barrier1.62336006
34MP0003634_abnormal_glial_cell1.58780927
35MP0003279_aneurysm1.56032252
36MP0002735_abnormal_chemical_nociception1.53769790
37MP0002822_catalepsy1.53541956
38MP0000749_muscle_degeneration1.50820903
39MP0001984_abnormal_olfaction1.49440169
40MP0008877_abnormal_DNA_methylation1.48230155
41MP0009384_cardiac_valve_regurgitation1.46697725
42MP0002734_abnormal_mechanical_nocicepti1.42234747
43MP0000955_abnormal_spinal_cord1.41948185
44MP0005171_absent_coat_pigmentation1.40159571
45MP0001958_emphysema1.39950285
46MP0004130_abnormal_muscle_cell1.38847809
47MP0003136_yellow_coat_color1.37298506
48MP0003632_abnormal_nervous_system1.37156020
49MP0005410_abnormal_fertilization1.36645128
50MP0003045_fibrosis1.35696979
51MP0004145_abnormal_muscle_electrophysio1.32440916
52MP0002067_abnormal_sensory_capabilities1.30591455
53MP0004134_abnormal_chest_morphology1.26877770
54MP0005503_abnormal_tendon_morphology1.23767897
55MP0002882_abnormal_neuron_morphology1.23070210
56MP0003633_abnormal_nervous_system1.22607849
57MP0003631_nervous_system_phenotype1.22441524
58MP0005275_abnormal_skin_tensile1.20999107
59MP0003283_abnormal_digestive_organ1.19451556
60MP0001661_extended_life_span1.18927682
61MP0005670_abnormal_white_adipose1.18086949
62MP0001177_atelectasis1.17412304
63MP0001905_abnormal_dopamine_level1.14755267
64MP0001501_abnormal_sleep_pattern1.11349346
65MP0000534_abnormal_ureter_morphology1.09815672
66MP0002733_abnormal_thermal_nociception1.09525004
67MP0002557_abnormal_social/conspecific_i1.09017397
68MP0001970_abnormal_pain_threshold1.07978541
69MP0001968_abnormal_touch/_nociception1.07881547
70MP0003942_abnormal_urinary_system1.07140307
71MP0003075_altered_response_to1.06728081
72MP0002066_abnormal_motor_capabilities/c1.05330224
73MP0004811_abnormal_neuron_physiology1.04106218
74MP0004043_abnormal_pH_regulation1.03455826
75MP0001963_abnormal_hearing_physiology0.98451018
76MP0002184_abnormal_innervation0.98024208
77MP0002736_abnormal_nociception_after0.97577480
78MP0002152_abnormal_brain_morphology0.97562660
79MP0005257_abnormal_intraocular_pressure0.96632730
80MP0002108_abnormal_muscle_morphology0.96181924
81MP0008438_abnormal_cutaneous_collagen0.95739284
82MP0000428_abnormal_craniofacial_morphol0.95681618
83MP0005386_behavior/neurological_phenoty0.95256596
84MP0004924_abnormal_behavior0.95256596
85MP0005409_darkened_coat_color0.94943245
86MP0004036_abnormal_muscle_relaxation0.94810681
87MP0005595_abnormal_vascular_smooth0.94328051
88MP0009250_abnormal_appendicular_skeleto0.93724204
89MP0002229_neurodegeneration0.91943451
90MP0000537_abnormal_urethra_morphology0.91496950
91MP0000604_amyloidosis0.88847856
92MP0003115_abnormal_respiratory_system0.88828869
93MP0003122_maternal_imprinting0.88713981
94MP0000759_abnormal_skeletal_muscle0.87417160
95MP0000566_synostosis0.87077961
96MP0000639_abnormal_adrenal_gland0.86819919
97MP0000747_muscle_weakness0.85738720
98MP0005646_abnormal_pituitary_gland0.85020907
99MP0000462_abnormal_digestive_system0.83522438
100MP0005187_abnormal_penis_morphology0.82674489
101MP0002090_abnormal_vision0.82443902
102MP0001502_abnormal_circadian_rhythm0.81552833
103MP0004084_abnormal_cardiac_muscle0.81196200
104MP0002295_abnormal_pulmonary_circulatio0.80693594
105MP0000569_abnormal_digit_pigmentation0.79798168
106MP0003385_abnormal_body_wall0.79742364
107MP0003787_abnormal_imprinting0.79205880
108MP0004215_abnormal_myocardial_fiber0.78820484
109MP0005620_abnormal_muscle_contractility0.78157397
110MP0004087_abnormal_muscle_fiber0.77978846
111MP0006138_congestive_heart_failure0.77844489
112MP0002089_abnormal_postnatal_growth/wei0.77355762
113MP0003698_abnormal_male_reproductive0.76601402
114MP0004142_abnormal_muscle_tone0.75103199
115MP0002133_abnormal_respiratory_system0.74249369
116MP0005388_respiratory_system_phenotype0.74249369
117MP0010678_abnormal_skin_adnexa0.73889013
118MP0002168_other_aberrant_phenotype0.73777512
119MP0003091_abnormal_cell_migration0.71649578
120MP0005508_abnormal_skeleton_morphology0.71522602
121MP0002909_abnormal_adrenal_gland0.70919370
122MP0003137_abnormal_impulse_conducting0.69751389
123MP0004233_abnormal_muscle_weight0.69708974
124MP0005551_abnormal_eye_electrophysiolog0.69021337
125MP0003950_abnormal_plasma_membrane0.68236360
126MP0008874_decreased_physiological_sensi0.68162628
127MP0006276_abnormal_autonomic_nervous0.66613039
128MP0002269_muscular_atrophy0.65210164
129MP0001348_abnormal_lacrimal_gland0.63171336
130MP0000733_abnormal_muscle_development0.61749465
131MP0000013_abnormal_adipose_tissue0.61054560

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)4.00416094
2Aplasia involving bones of the extremities (HP:0009825)3.86478215
3Aplasia involving bones of the upper limbs (HP:0009823)3.86478215
4Aplasia of the phalanges of the hand (HP:0009802)3.86478215
5Ankle clonus (HP:0011448)3.75621713
6Obstructive sleep apnea (HP:0002870)3.72161966
7Abnormality of binocular vision (HP:0011514)3.59738552
8Diplopia (HP:0000651)3.59738552
9Megalencephaly (HP:0001355)3.29519730
10Protrusio acetabuli (HP:0003179)3.29198699
11Action tremor (HP:0002345)3.23617330
12Humeroradial synostosis (HP:0003041)3.19339862
13Synostosis involving the elbow (HP:0003938)3.19339862
14Focal motor seizures (HP:0011153)3.18332884
15Neurofibrillary tangles (HP:0002185)3.14805238
16Hyporeflexia of lower limbs (HP:0002600)3.05177908
17Male infertility (HP:0003251)2.92955300
18Gonadal dysgenesis (HP:0000133)2.85985600
19Type 1 muscle fiber predominance (HP:0003803)2.84393265
20Broad metatarsal (HP:0001783)2.83938615
21Supranuclear gaze palsy (HP:0000605)2.79092928
22Focal seizures (HP:0007359)2.78555124
23Abnormal eating behavior (HP:0100738)2.77631381
24Premature rupture of membranes (HP:0001788)2.74144077
25Bundle branch block (HP:0011710)2.73448148
26Muscle fiber splitting (HP:0003555)2.69324394
27Coronal craniosynostosis (HP:0004440)2.69296704
28Cerebral inclusion bodies (HP:0100314)2.55226807
29Turricephaly (HP:0000262)2.49663006
30Overriding aorta (HP:0002623)2.48089563
31Shallow orbits (HP:0000586)2.48011145
32Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.44390712
33Degeneration of the lateral corticospinal tracts (HP:0002314)2.44390712
34Aortic aneurysm (HP:0004942)2.42397038
35Febrile seizures (HP:0002373)2.41950279
36Onion bulb formation (HP:0003383)2.38692897
37Clumsiness (HP:0002312)2.37956744
38Alacrima (HP:0000522)2.37723878
39Insomnia (HP:0100785)2.37249693
40Atonic seizures (HP:0010819)2.35952245
41Akinesia (HP:0002304)2.32923973
42Mesangial abnormality (HP:0001966)2.31235059
43Truncal ataxia (HP:0002078)2.29606205
44Intention tremor (HP:0002080)2.27909135
45Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.27106981
46Papilledema (HP:0001085)2.26819658
47Midline defect of the nose (HP:0004122)2.26673996
48Spastic gait (HP:0002064)2.26551173
49Neoplasm of the heart (HP:0100544)2.25357135
50Insidious onset (HP:0003587)2.21388010
51Termporal pattern (HP:0011008)2.21388010
52Trigonocephaly (HP:0000243)2.20196755
53Dysmetria (HP:0001310)2.19321456
54Foot dorsiflexor weakness (HP:0009027)2.18886053
55Abnormality of the corticospinal tract (HP:0002492)2.16951419
56Bronchomalacia (HP:0002780)2.16633050
57Cerebral aneurysm (HP:0004944)2.15935446
58Hemiplegia (HP:0002301)2.15577419
59Bell-shaped thorax (HP:0001591)2.14605296
60Distal upper limb amyotrophy (HP:0007149)2.12572043
61Upper limb amyotrophy (HP:0009129)2.12572043
62Peripheral hypomyelination (HP:0007182)2.12155226
63Generalized tonic-clonic seizures (HP:0002069)2.11369202
64Progressive cerebellar ataxia (HP:0002073)2.11226837
65Heart block (HP:0012722)2.09974644
66Bladder diverticulum (HP:0000015)2.08743730
67Aortic dissection (HP:0002647)2.08461241
68Vascular tortuosity (HP:0004948)2.08403523
69Abnormal atrioventricular conduction (HP:0005150)2.08181783
70Overgrowth (HP:0001548)2.07721858
71Round ear (HP:0100830)2.07110961
72Sleep apnea (HP:0010535)2.06808200
73Clonus (HP:0002169)2.06012306
74Hypoventilation (HP:0002791)2.05908170
75Dysdiadochokinesis (HP:0002075)2.04874589
76Torticollis (HP:0000473)2.02418738
77Cerebral hypomyelination (HP:0006808)2.02165595
78Abnormality of the foot musculature (HP:0001436)2.02036260
79Anteriorly placed anus (HP:0001545)2.01702536
80Abnormality of the middle phalanges of the toes (HP:0010183)2.01327202
81Abnormality of skeletal muscle fiber size (HP:0012084)2.01129152
82Lower limb muscle weakness (HP:0007340)2.00317790
83Epileptic encephalopathy (HP:0200134)1.99990602
84Bowel diverticulosis (HP:0005222)1.98694593
85Abnormality of the diencephalon (HP:0010662)1.98661351
86Short 4th metacarpal (HP:0010044)1.98458138
87Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.98458138
88Hemiparesis (HP:0001269)1.97824896
89Fetal akinesia sequence (HP:0001989)1.97112290
90Mild short stature (HP:0003502)1.97095302
91Difficulty running (HP:0009046)1.96832377
92Hypoplastic left heart (HP:0004383)1.96561451
93Spinal rigidity (HP:0003306)1.94336539
94Mitral regurgitation (HP:0001653)1.94113173
95Increased variability in muscle fiber diameter (HP:0003557)1.92100339
96Urinary urgency (HP:0000012)1.91779815
97Exercise-induced myalgia (HP:0003738)1.91720583
98Lower limb amyotrophy (HP:0007210)1.90950871
99Rapidly progressive (HP:0003678)1.90035770
100Rigidity (HP:0002063)1.89120315
101Postural instability (HP:0002172)1.88892821
102Buphthalmos (HP:0000557)1.88164182
103Hypoplasia of the iris (HP:0007676)1.87283112
104Depression (HP:0000716)1.86562069
105Hypoplastic ischia (HP:0003175)1.84977166
106Muscle fiber inclusion bodies (HP:0100299)1.84782241
107Urinary bladder sphincter dysfunction (HP:0002839)1.84403668
108Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.84353923
109Neonatal short-limb short stature (HP:0008921)1.84234416
110Arterial tortuosity (HP:0005116)1.84196866
111Tetraplegia (HP:0002445)1.84143906
112Decreased lacrimation (HP:0000633)1.83684937
113Flat cornea (HP:0007720)1.83167869
114Ankle contracture (HP:0006466)1.82900466
115Testicular neoplasm (HP:0010788)1.80267462
116Abnormality of the parietal bone (HP:0002696)1.80246892
117Renovascular hypertension (HP:0100817)1.79701239
118Postural tremor (HP:0002174)1.78248079
119Nemaline bodies (HP:0003798)1.78021593
120Blue irides (HP:0000635)1.77759462
121Macroorchidism (HP:0000053)1.77693477
122Hammertoe (HP:0001765)1.76511129
123Atrioventricular block (HP:0001678)1.76273611
124Wormian bones (HP:0002645)1.75636499
125Arnold-Chiari malformation (HP:0002308)1.75618664
126EMG: myopathic abnormalities (HP:0003458)1.75431881
127Bowel incontinence (HP:0002607)1.74429519
128Decreased motor nerve conduction velocity (HP:0003431)1.74145873
129Renal duplication (HP:0000075)1.73860397
130Pointed chin (HP:0000307)1.73229395
131Myotonia (HP:0002486)1.72073458
132Scanning speech (HP:0002168)1.71407224
133Absence seizures (HP:0002121)1.71153866
134Germ cell neoplasia (HP:0100728)1.70908022
135Focal segmental glomerulosclerosis (HP:0000097)1.70303762
136Abnormality of the lower motor neuron (HP:0002366)1.69912358
137Diaphragmatic weakness (HP:0009113)1.69795743
138Hyperacusis (HP:0010780)1.68779824
139Stridor (HP:0010307)1.68723628
140Infantile muscular hypotonia (HP:0008947)1.67088435
141Abnormal auditory evoked potentials (HP:0006958)1.67069761
142Hand muscle atrophy (HP:0009130)1.66093203
143Gaze-evoked nystagmus (HP:0000640)1.65766836
144Split foot (HP:0001839)1.64822769
145Abnormality of the ischium (HP:0003174)1.62141916
146Increased circulating renin level (HP:0000848)1.62013696
147Mixed hearing impairment (HP:0000410)1.61553469
148Elfin facies (HP:0004428)1.61519449
149Visual hallucinations (HP:0002367)1.61167606
150Neuronal loss in central nervous system (HP:0002529)1.60516342
151Narrow palate (HP:0000189)1.58856622
152Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.56505088
153Annular pancreas (HP:0001734)1.56336160

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRKD33.21411799
2EPHA42.99193573
3TYRO32.78766447
4STK392.67122805
5NTRK32.46297112
6WNK12.31379199
7DDR22.16547499
8FGFR22.12401855
9NTRK11.98761408
10NTRK21.98347015
11PAK61.98064304
12MAP3K41.96054575
13EPHB11.92693604
14ICK1.90277780
15WNK41.79250784
16LMTK21.77441020
17OXSR11.73306196
18RIPK11.66164974
19DAPK21.65155159
20TNIK1.64943011
21MINK11.56406645
22PHKG21.53900858
23PHKG11.53900858
24CAMK1G1.52810228
25SGK4941.52614192
26SGK2231.52614192
27KSR21.50041361
28PRPF4B1.45271868
29PDGFRA1.42294786
30MAP3K91.39381155
31MAPK121.36950375
32TRIB31.32741565
33CASK1.32478266
34UHMK11.26335197
35DMPK1.22858642
36MARK11.19601374
37PNCK1.17947530
38PRKCH1.17584821
39CDK51.17539402
40BMX1.15242762
41PTK2B1.12601860
42OBSCN1.11818331
43ROCK21.10479004
44STK381.09373142
45MYLK1.06270430
46CAMKK11.05405210
47CSNK1A1L1.04246014
48MAPKAPK51.02214965
49ARAF1.00396581
50PKN10.98827685
51LATS10.98585998
52PAK30.97734994
53CDC42BPA0.96918920
54RET0.94396920
55SIK10.93917516
56WNK30.93704350
57GRK50.92670483
58SGK30.92293366
59MET0.91351777
60TTN0.88712212
61NEK60.88459189
62CAMK1D0.88242973
63CAMK2B0.86787235
64ROCK10.84719245
65STK110.80809643
66MAPK70.80328007
67MAP2K40.80200530
68PDGFRB0.80085391
69PLK20.79095569
70FGFR10.78618453
71MAP2K70.77706778
72LATS20.75979651
73MARK20.75493961
74MAP3K20.75410669
75MAPK130.75394156
76MAP3K130.74662294
77SGK20.73117684
78CSNK1G20.72873467
79PRKD10.71047717
80DYRK1A0.70662461
81TNK20.69230283
82KSR10.69184135
83CDK120.69035826
84SGK10.67375898
85CAMK2A0.66592296
86CDK190.64053093
87PDPK10.63767919
88CAMK2G0.63514890
89CDK150.63508897
90CAMK2D0.62567667
91MOS0.61767883
92CDK140.61358791
93PRKCG0.60873678
94AKT30.59969275
95MAP2K10.59358181
96MAP3K70.59223333
97PDK10.58955594
98CDK180.58540353
99MAPK40.58533394
100CAMK40.58189101
101PRKG10.57397811
102PTK60.56458786
103CAMK10.55424685
104BRD40.55410247
105LIMK10.55360041
106PRKD20.55107584
107PINK10.55014868
108FGR0.54144711
109MAPK100.52966862
110TESK10.52569128
111DAPK30.52399777
112PRKCE0.52356186
113CDK11A0.52085463
114PAK20.51744229
115ALK0.51738326
116RIPK40.50347212
117FYN0.50339325
118RPS6KA30.49833237
119PTK20.49179155
120CSNK1G30.48334989
121JAK10.47928209
122ERBB20.47297179
123FES0.44533830
124PRKG20.42451679
125RPS6KA20.40183550
126PIK3CA0.39789623

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.18679425
2Glutamatergic synapse_Homo sapiens_hsa047242.00997265
3GABAergic synapse_Homo sapiens_hsa047271.97080259
4Circadian entrainment_Homo sapiens_hsa047131.93305682
5Nicotine addiction_Homo sapiens_hsa050331.88746436
6Gastric acid secretion_Homo sapiens_hsa049711.87280367
7Salivary secretion_Homo sapiens_hsa049701.82250730
8Dorso-ventral axis formation_Homo sapiens_hsa043201.81694623
9Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.80722263
10Fatty acid biosynthesis_Homo sapiens_hsa000611.72776252
11Axon guidance_Homo sapiens_hsa043601.72628706
12Morphine addiction_Homo sapiens_hsa050321.68394580
13Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.67086501
14Long-term potentiation_Homo sapiens_hsa047201.64657959
15Olfactory transduction_Homo sapiens_hsa047401.58688087
16Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.58457522
17Renin secretion_Homo sapiens_hsa049241.57916692
18Amphetamine addiction_Homo sapiens_hsa050311.56533870
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.55643868
20Synaptic vesicle cycle_Homo sapiens_hsa047211.53048317
21Histidine metabolism_Homo sapiens_hsa003401.52970775
22Cocaine addiction_Homo sapiens_hsa050301.50800341
23cAMP signaling pathway_Homo sapiens_hsa040241.44020548
24Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.43864627
25Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.43850684
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.43767972
27Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.42405925
28Dopaminergic synapse_Homo sapiens_hsa047281.40118975
29Insulin secretion_Homo sapiens_hsa049111.39718692
30Hedgehog signaling pathway_Homo sapiens_hsa043401.38184125
31ECM-receptor interaction_Homo sapiens_hsa045121.38183358
32Cholinergic synapse_Homo sapiens_hsa047251.31512091
33Long-term depression_Homo sapiens_hsa047301.27402178
34Gap junction_Homo sapiens_hsa045401.20167111
35Oxytocin signaling pathway_Homo sapiens_hsa049211.20109957
36cGMP-PKG signaling pathway_Homo sapiens_hsa040221.16274817
37Phospholipase D signaling pathway_Homo sapiens_hsa040721.15435514
38Calcium signaling pathway_Homo sapiens_hsa040201.15223356
39Dilated cardiomyopathy_Homo sapiens_hsa054141.13010461
40Basal cell carcinoma_Homo sapiens_hsa052171.11567233
41Vascular smooth muscle contraction_Homo sapiens_hsa042701.11092737
42Melanogenesis_Homo sapiens_hsa049161.09384735
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.09299910
44Prion diseases_Homo sapiens_hsa050201.08940291
45GnRH signaling pathway_Homo sapiens_hsa049121.05976053
46Vitamin B6 metabolism_Homo sapiens_hsa007501.02695895
47Protein digestion and absorption_Homo sapiens_hsa049741.02448351
48Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.02326834
49Estrogen signaling pathway_Homo sapiens_hsa049151.02020279
50Phosphatidylinositol signaling system_Homo sapiens_hsa040700.97193811
51Glioma_Homo sapiens_hsa052140.96338676
52ErbB signaling pathway_Homo sapiens_hsa040120.95367779
53Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.93544874
54Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.93422325
55beta-Alanine metabolism_Homo sapiens_hsa004100.92721561
56Bile secretion_Homo sapiens_hsa049760.92546540
57Focal adhesion_Homo sapiens_hsa045100.92418928
58Serotonergic synapse_Homo sapiens_hsa047260.91902241
59Ovarian steroidogenesis_Homo sapiens_hsa049130.91775456
60Taste transduction_Homo sapiens_hsa047420.89790915
61Circadian rhythm_Homo sapiens_hsa047100.87259721
62Type II diabetes mellitus_Homo sapiens_hsa049300.86457777
63Pancreatic secretion_Homo sapiens_hsa049720.85640358
64Thyroid hormone synthesis_Homo sapiens_hsa049180.85637447
65Tight junction_Homo sapiens_hsa045300.84760054
66Mineral absorption_Homo sapiens_hsa049780.84714997
67Amoebiasis_Homo sapiens_hsa051460.84031754
68Thyroid hormone signaling pathway_Homo sapiens_hsa049190.83789228
69Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.82695823
70Arginine and proline metabolism_Homo sapiens_hsa003300.82442805
71Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.80826162
72Renal cell carcinoma_Homo sapiens_hsa052110.79151500
73Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.78618986
74Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.77662482
75Rap1 signaling pathway_Homo sapiens_hsa040150.77577611
76Fatty acid elongation_Homo sapiens_hsa000620.76270555
77Fatty acid metabolism_Homo sapiens_hsa012120.75293931
78Hippo signaling pathway_Homo sapiens_hsa043900.74795189
79Carbohydrate digestion and absorption_Homo sapiens_hsa049730.73979675
80Endocytosis_Homo sapiens_hsa041440.73473034
81Choline metabolism in cancer_Homo sapiens_hsa052310.72943990
82Sphingolipid signaling pathway_Homo sapiens_hsa040710.71467867
83Proteoglycans in cancer_Homo sapiens_hsa052050.68730678
84Ras signaling pathway_Homo sapiens_hsa040140.68430607
85Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.67487285
86* Wnt signaling pathway_Homo sapiens_hsa043100.62981823
87Ether lipid metabolism_Homo sapiens_hsa005650.62846738
88Glucagon signaling pathway_Homo sapiens_hsa049220.62493027
89MAPK signaling pathway_Homo sapiens_hsa040100.62420861
90Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.61647117
91Regulation of actin cytoskeleton_Homo sapiens_hsa048100.60240981
92Inositol phosphate metabolism_Homo sapiens_hsa005620.57730896
93Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.57619170
94Neurotrophin signaling pathway_Homo sapiens_hsa047220.57044892
95Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.54825844
96Arginine biosynthesis_Homo sapiens_hsa002200.54749275
97PPAR signaling pathway_Homo sapiens_hsa033200.54619770
98Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.54507394
99AMPK signaling pathway_Homo sapiens_hsa041520.54425812
100Vibrio cholerae infection_Homo sapiens_hsa051100.54053331
101Oocyte meiosis_Homo sapiens_hsa041140.52955460
102VEGF signaling pathway_Homo sapiens_hsa043700.52103094
103Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.51245589
104Insulin signaling pathway_Homo sapiens_hsa049100.50102581
105Cardiac muscle contraction_Homo sapiens_hsa042600.49537001
106Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.49218740
107Endometrial cancer_Homo sapiens_hsa052130.48159625
108TGF-beta signaling pathway_Homo sapiens_hsa043500.48063062
109Adherens junction_Homo sapiens_hsa045200.47569422
110Lysine degradation_Homo sapiens_hsa003100.47241844
111Steroid biosynthesis_Homo sapiens_hsa001000.45592627
112Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44015596
113mTOR signaling pathway_Homo sapiens_hsa041500.43775138
114Notch signaling pathway_Homo sapiens_hsa043300.43072118
115AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.42429552
116Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.42256199
117Glycosaminoglycan degradation_Homo sapiens_hsa005310.38900534

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