DACH1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a chromatin-associated protein that associates with other DNA-binding transcription factors to regulate gene expression and cell fate determination during development. The protein contains a Ski domain that is highly conserved from Drosophila to human. Expression of this gene is lost in some forms of metastatic cancer, and is correlated with poor prognosis. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)5.33348288
2behavioral response to nicotine (GO:0035095)5.07828039
3definitive hemopoiesis (GO:0060216)4.72182053
4nucleobase catabolic process (GO:0046113)4.59287183
5retinal ganglion cell axon guidance (GO:0031290)4.51902068
6glomerular visceral epithelial cell development (GO:0072015)4.38200524
7presynaptic membrane assembly (GO:0097105)4.33332978
8glomerular epithelial cell development (GO:0072310)3.74738862
9substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.65472837
10substrate-independent telencephalic tangential migration (GO:0021826)3.65472837
11type B pancreatic cell development (GO:0003323)3.64899210
12negative regulation of cytosolic calcium ion concentration (GO:0051481)3.64708256
13intraciliary transport (GO:0042073)3.63896435
14regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.57711258
15postsynaptic membrane organization (GO:0001941)3.56052712
16layer formation in cerebral cortex (GO:0021819)3.55107838
17dendritic spine morphogenesis (GO:0060997)3.52330582
18response to pheromone (GO:0019236)3.50476857
19transmission of nerve impulse (GO:0019226)3.43199794
20limb bud formation (GO:0060174)3.38725113
21glandular epithelial cell development (GO:0002068)3.36449375
22negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.34957986
23hindbrain development (GO:0030902)3.31455387
24cerebral cortex radially oriented cell migration (GO:0021799)3.30070118
25prepulse inhibition (GO:0060134)3.27127028
26negative regulation of vascular permeability (GO:0043116)3.26817541
27glomerular basement membrane development (GO:0032836)3.25877329
28dopaminergic neuron differentiation (GO:0071542)3.21526971
29cell migration in hindbrain (GO:0021535)3.19707824
30epithelial cilium movement (GO:0003351)3.19126710
31cornea development in camera-type eye (GO:0061303)3.16400263
32megakaryocyte development (GO:0035855)3.16258378
33nonmotile primary cilium assembly (GO:0035058)3.15339332
34axonal fasciculation (GO:0007413)3.13157248
35positive regulation of gastrulation (GO:2000543)3.10192070
36spinal cord development (GO:0021510)3.09637742
37regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.08532016
38kidney morphogenesis (GO:0060993)3.06441574
39glomerulus development (GO:0032835)3.06127088
40central nervous system projection neuron axonogenesis (GO:0021952)3.05404987
41ribosomal small subunit assembly (GO:0000028)3.04304667
42positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.03024421
43epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.01392282
44ionotropic glutamate receptor signaling pathway (GO:0035235)2.99619838
45olfactory bulb development (GO:0021772)2.99076993
46limb development (GO:0060173)2.98074690
47appendage development (GO:0048736)2.98074690
48somite development (GO:0061053)2.97501947
49mechanosensory behavior (GO:0007638)2.96718301
50regulation of growth hormone secretion (GO:0060123)2.95866156
51regulation of synapse structural plasticity (GO:0051823)2.92703587
52neuron fate specification (GO:0048665)2.92675837
53neuronal ion channel clustering (GO:0045161)2.89486418
54neuron cell-cell adhesion (GO:0007158)2.87965809
55regulation of timing of cell differentiation (GO:0048505)2.87042654
56central nervous system neuron axonogenesis (GO:0021955)2.86141705
57smoothened signaling pathway (GO:0007224)2.82160082
58positive regulation of CREB transcription factor activity (GO:0032793)2.82138619
59regulation of development, heterochronic (GO:0040034)2.80305726
60regulation of cardioblast proliferation (GO:0003264)2.79995032
61regulation of secondary heart field cardioblast proliferation (GO:0003266)2.79995032
62protein localization to synapse (GO:0035418)2.78700989
63regulation of respiratory system process (GO:0044065)2.78554858
64negative regulation of translation, ncRNA-mediated (GO:0040033)2.78427010
65regulation of translation, ncRNA-mediated (GO:0045974)2.78427010
66negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.78427010
67negative regulation of axon guidance (GO:1902668)2.76988972
68negative regulation of osteoblast proliferation (GO:0033689)2.76397970
69neuron recognition (GO:0008038)2.75410582
70establishment of mitochondrion localization (GO:0051654)2.75059287
71ganglion development (GO:0061548)2.73424950
72epithelial cell differentiation involved in kidney development (GO:0035850)2.71812021
73positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.71686476
74synapse assembly (GO:0007416)2.71416700
75cilium movement (GO:0003341)2.71172102
76glutamate receptor signaling pathway (GO:0007215)2.70452531
77neurotransmitter-gated ion channel clustering (GO:0072578)2.70177784
78peptidyl-tyrosine autophosphorylation (GO:0038083)2.69214209
79neural tube formation (GO:0001841)2.68124637
80protein localization to cilium (GO:0061512)2.66789360
81dendrite morphogenesis (GO:0048813)2.66735796
82thalamus development (GO:0021794)2.66222192
83adult walking behavior (GO:0007628)2.65937659
84startle response (GO:0001964)2.65882830
85mRNA splice site selection (GO:0006376)2.64882143
86venous blood vessel morphogenesis (GO:0048845)2.63351311
87cilium assembly (GO:0042384)2.62356097
88dentate gyrus development (GO:0021542)2.62063854
89cilium organization (GO:0044782)2.61409601
90positive regulation of dendritic spine morphogenesis (GO:0061003)2.61276594
91synaptic transmission, glutamatergic (GO:0035249)2.61177840
92photoreceptor cell development (GO:0042461)2.61034625
93brain morphogenesis (GO:0048854)2.60514656
94G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.59843933
95glial cell proliferation (GO:0014009)2.59767048
96positive regulation of vascular permeability (GO:0043117)2.59713180
97cell proliferation in forebrain (GO:0021846)2.59197142
98endocrine pancreas development (GO:0031018)2.58308521
99positive regulation of growth hormone secretion (GO:0060124)2.57569765
100negative regulation of RNA splicing (GO:0033119)2.57111078
101glandular epithelial cell differentiation (GO:0002067)2.56761344
102cilium morphogenesis (GO:0060271)2.56069448
103calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.55683285
104synaptic transmission, cholinergic (GO:0007271)2.52733374
105neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.51501587
106antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.51251220
107mitochondrion transport along microtubule (GO:0047497)2.50391151
108establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.50391151
109positive regulation of synaptic transmission, GABAergic (GO:0032230)2.50157805
110neuron migration (GO:0001764)2.50033256
111exocrine pancreas development (GO:0031017)2.49860120
112response to auditory stimulus (GO:0010996)2.49239818
113neuron-neuron synaptic transmission (GO:0007270)2.49176771
114retina layer formation (GO:0010842)2.49054797
115cranial nerve morphogenesis (GO:0021602)2.48889539
116pancreas development (GO:0031016)2.48849650
117protein polyglutamylation (GO:0018095)2.48648229
118positive regulation of synapse assembly (GO:0051965)2.48632926
119anterograde axon cargo transport (GO:0008089)2.48605132
120glucocorticoid receptor signaling pathway (GO:0042921)2.47001493
121peristalsis (GO:0030432)2.45821892
122negative regulation of axon extension (GO:0030517)2.45438568
123negative regulation of nitric-oxide synthase activity (GO:0051001)2.45349528
124lymph vessel development (GO:0001945)2.44363457
125striatum development (GO:0021756)2.44220249
126insulin secretion (GO:0030073)2.43823111
127G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.43790872
128COPI coating of Golgi vesicle (GO:0048205)2.41904833
129Golgi transport vesicle coating (GO:0048200)2.41904833
130cranial nerve development (GO:0021545)2.40472381
131forebrain neuron differentiation (GO:0021879)2.40075747
132somite rostral/caudal axis specification (GO:0032525)2.39984970
133nucleosome disassembly (GO:0006337)2.39873722
134protein-DNA complex disassembly (GO:0032986)2.39873722
135cerebellar Purkinje cell differentiation (GO:0021702)2.39816532
136SMAD protein complex assembly (GO:0007183)2.39664200
137lymphoid progenitor cell differentiation (GO:0002320)2.39030694
138detection of calcium ion (GO:0005513)2.38202808
139lymphangiogenesis (GO:0001946)2.37043854
140positive regulation of neuroblast proliferation (GO:0002052)2.36801020
141cardiac muscle cell proliferation (GO:0060038)2.36404600
142negative regulation of circadian rhythm (GO:0042754)2.35327439
143catecholamine transport (GO:0051937)2.35241804
144establishment of nucleus localization (GO:0040023)2.33931906
145activation of protein kinase A activity (GO:0034199)2.31973190
146urogenital system development (GO:0001655)2.31694315
147negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.29687343
148primitive streak formation (GO:0090009)2.29466328
149presynaptic membrane organization (GO:0097090)2.29447970
150peptidyl-lysine dimethylation (GO:0018027)2.29211746
151sprouting angiogenesis (GO:0002040)2.29192939
152insulin-like growth factor receptor signaling pathway (GO:0048009)2.28087421
153auditory behavior (GO:0031223)2.28035854
154adenosine receptor signaling pathway (GO:0001973)2.26860944
155regulation of long-term neuronal synaptic plasticity (GO:0048169)2.26252139
156neuron fate determination (GO:0048664)2.26147668
157regulation of vascular permeability (GO:0043114)2.25974555
158embryonic foregut morphogenesis (GO:0048617)2.24598675
159secretory granule organization (GO:0033363)2.24168584
160histone H3-K4 trimethylation (GO:0080182)2.24117091
161neuronal stem cell maintenance (GO:0097150)2.23611322
162mating behavior (GO:0007617)2.23486964
163positive regulation of neural precursor cell proliferation (GO:2000179)2.23288013
164positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.22783457
165retrograde transport, vesicle recycling within Golgi (GO:0000301)2.22090212
166positive regulation of insulin secretion (GO:0032024)2.21944680
167vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.21830629
168cAMP biosynthetic process (GO:0006171)2.21387012
169cochlea development (GO:0090102)2.21324938
170blood vessel maturation (GO:0001955)2.20110310
171regulation of neuronal synaptic plasticity (GO:0048168)2.20086559
172artery development (GO:0060840)2.19961826
173dendritic spine organization (GO:0097061)2.19450697
174embryonic hemopoiesis (GO:0035162)2.19436886
175regulation of mRNA splicing, via spliceosome (GO:0048024)2.19249500
176interleukin-1-mediated signaling pathway (GO:0070498)2.18040911
177sequestering of metal ion (GO:0051238)2.17456225
178dorsal/ventral axis specification (GO:0009950)2.16527763
179response to amphetamine (GO:0001975)2.15952266
180cerebellum development (GO:0021549)2.15678866

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.01699422
2* EZH2_27304074_Chip-Seq_ESCs_Mouse3.13857443
3* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.05380479
4SCL_19346495_ChIP-Seq_HPC-7_Human2.97160462
5* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.80595976
6* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.62149007
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.59720623
8* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.56792424
9TP63_19390658_ChIP-ChIP_HaCaT_Human2.53491838
10* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.52553762
11* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.52098595
12* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.52098595
13* EZH2_27294783_Chip-Seq_ESCs_Mouse2.51152296
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.48767113
15* TAF15_26573619_Chip-Seq_HEK293_Human2.44735320
16* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.41270015
17* RNF2_27304074_Chip-Seq_ESCs_Mouse2.40707826
18* EED_16625203_ChIP-ChIP_MESCs_Mouse2.38111821
19* PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.34968000
20IGF1R_20145208_ChIP-Seq_DFB_Human2.32682990
21* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.32165738
22DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.26588903
23* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.24336945
24* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.17337689
25VDR_22108803_ChIP-Seq_LS180_Human2.13177731
26* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.12093967
27GBX2_23144817_ChIP-Seq_PC3_Human2.12025001
28CBX2_27304074_Chip-Seq_ESCs_Mouse2.08458180
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.06427260
30* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.06165146
31* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.92566675
32SALL1_21062744_ChIP-ChIP_HESCs_Human1.92309834
33TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.89628328
34CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.85692270
35DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.85395102
36* RING1B_27294783_Chip-Seq_NPCs_Mouse1.83846694
37RING1B_27294783_Chip-Seq_ESCs_Mouse1.79863321
38* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.79537807
39RNF2_27304074_Chip-Seq_NSC_Mouse1.78966570
40* EWS_26573619_Chip-Seq_HEK293_Human1.78510500
41* RARB_27405468_Chip-Seq_BRAIN_Mouse1.77771701
42* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.70091068
43CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.69423197
44* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.68958654
45REST_21632747_ChIP-Seq_MESCs_Mouse1.68149379
46POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.66109560
47TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.66109560
48ZNF274_21170338_ChIP-Seq_K562_Hela1.63013908
49AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.58166263
50PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.57979299
51GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53661349
52* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.50009546
53STAT6_21828071_ChIP-Seq_BEAS2B_Human1.49782959
54DROSHA_22980978_ChIP-Seq_HELA_Human1.48711829
55PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.48600908
56TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.47846358
57* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.46615771
58IKZF1_21737484_ChIP-ChIP_HCT116_Human1.44531297
59EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.43145747
60SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42519664
61WT1_19549856_ChIP-ChIP_CCG9911_Human1.40718367
62AR_25329375_ChIP-Seq_VCAP_Human1.37859027
63STAT3_23295773_ChIP-Seq_U87_Human1.33971674
64TCF7_22412390_ChIP-Seq_EML_Mouse1.31134035
65* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.30847868
66* HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.30701251
67TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30183616
68BP1_19119308_ChIP-ChIP_Hs578T_Human1.30073502
69MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.30004680
70FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.26613907
71UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.26346515
72ZNF217_24962896_ChIP-Seq_MCF-7_Human1.26016660
73NANOG_18555785_Chip-Seq_ESCs_Mouse1.25875374
74KDM2B_26808549_Chip-Seq_K562_Human1.24738628
75ER_23166858_ChIP-Seq_MCF-7_Human1.24714642
76RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.24683046
77TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.24666403
78POU3F2_20337985_ChIP-ChIP_501MEL_Human1.23830792
79* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.23620391
80FLI1_27457419_Chip-Seq_LIVER_Mouse1.23479070
81* TCF4_23295773_ChIP-Seq_U87_Human1.23316941
82* BCAT_22108803_ChIP-Seq_LS180_Human1.22185436
83* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.20869620
84NR3C1_21868756_ChIP-Seq_MCF10A_Human1.20866126
85REST_18959480_ChIP-ChIP_MESCs_Mouse1.19849130
86RUNX2_22187159_ChIP-Seq_PCA_Human1.19311108
87RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.18229680
88NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.17834046
89ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.17788579
90ZFP281_27345836_Chip-Seq_ESCs_Mouse1.17153597
91CBP_20019798_ChIP-Seq_JUKART_Human1.17132049
92IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.17132049
93EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.16759076
94TAL1_26923725_Chip-Seq_HPCs_Mouse1.12039652
95* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.11623391
96* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.11047084
97CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.11003784
98RBPJ_22232070_ChIP-Seq_NCS_Mouse1.10503866
99ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.10484277
100* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.09516583
101IRF1_19129219_ChIP-ChIP_H3396_Human1.08927633
102* P300_19829295_ChIP-Seq_ESCs_Human1.08706092
103* CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.07911293
104SMAD4_21799915_ChIP-Seq_A2780_Human1.07179763
105SOX2_21211035_ChIP-Seq_LN229_Gbm1.05277352
106GATA2_21666600_ChIP-Seq_HMVEC_Human1.05012042
107GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.04917546
108* KDM2B_26808549_Chip-Seq_JURKAT_Human1.04507235
109P53_22387025_ChIP-Seq_ESCs_Mouse1.02985731
110* TP53_20018659_ChIP-ChIP_R1E_Mouse1.02900536
111EP300_21415370_ChIP-Seq_HL-1_Mouse1.02772770
112* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02678212
113CDX2_19796622_ChIP-Seq_MESCs_Mouse1.02454138
114* FLI1_21867929_ChIP-Seq_TH2_Mouse1.02387834
115KLF5_20875108_ChIP-Seq_MESCs_Mouse1.01339574
116* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.01046395
117* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.00557097
118PCGF2_27294783_Chip-Seq_NPCs_Mouse1.00407076
119P53_22127205_ChIP-Seq_FIBROBLAST_Human0.99894765
120* TCF4_22108803_ChIP-Seq_LS180_Human0.99879395
121RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.99551146
122CTBP2_25329375_ChIP-Seq_LNCAP_Human0.97920286
123MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.97547026
124MYC_22102868_ChIP-Seq_BL_Human0.97402641
125OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96987170
126* SMAD3_21741376_ChIP-Seq_EPCs_Human0.94888308
127* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.94536789
128FUS_26573619_Chip-Seq_HEK293_Human0.93531604
129ISL1_27105846_Chip-Seq_CPCs_Mouse0.93190018
130CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92592255
131NR3C1_23031785_ChIP-Seq_PC12_Mouse0.91447593
132MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.91202636
133CTBP1_25329375_ChIP-Seq_LNCAP_Human0.90336727
134KDM2B_26808549_Chip-Seq_DND41_Human0.88081917
135MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.87513366
136* SMAD3_21741376_ChIP-Seq_ESCs_Human0.86492587
137PIAS1_25552417_ChIP-Seq_VCAP_Human0.86123295
138PKCTHETA_26484144_Chip-Seq_BREAST_Human0.85999863
139* SOX3_22085726_ChIP-Seq_NPCs_Mouse0.85831620
140GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85473606
141* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84711699
142TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.84491307
143* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.84132440

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009780_abnormal_chondrocyte_physiolo3.05934769
2MP0003122_maternal_imprinting2.85840185
3MP0001879_abnormal_lymphatic_vessel2.77832541
4MP0010368_abnormal_lymphatic_system2.64850883
5MP0006072_abnormal_retinal_apoptosis2.64318511
6MP0005646_abnormal_pituitary_gland2.57982721
7MP0000566_synostosis2.49283976
8MP0003283_abnormal_digestive_organ2.48466502
9MP0005423_abnormal_somatic_nervous2.47896643
10MP0001188_hyperpigmentation2.38488809
11MP0002822_catalepsy2.27099283
12MP0002234_abnormal_pharynx_morphology2.18943554
13MP0002909_abnormal_adrenal_gland2.15667744
14MP0004808_abnormal_hematopoietic_stem2.08864977
15MP0003828_pulmonary_edema2.01864034
16MP0010030_abnormal_orbit_morphology1.97330192
17MP0000631_abnormal_neuroendocrine_gland1.96130068
18MP0003183_abnormal_peptide_metabolism1.92623078
19MP0005409_darkened_coat_color1.89122540
20MP0008995_early_reproductive_senescence1.87739899
21MP0000013_abnormal_adipose_tissue1.85070124
22MP0004859_abnormal_synaptic_plasticity1.84213749
23MP0003121_genomic_imprinting1.83038896
24MP0006292_abnormal_olfactory_placode1.82437576
25MP0008789_abnormal_olfactory_epithelium1.78376627
26MP0003943_abnormal_hepatobiliary_system1.76888845
27MP0005394_taste/olfaction_phenotype1.76531328
28MP0005499_abnormal_olfactory_system1.76531328
29MP0001529_abnormal_vocalization1.76466461
30MP0002877_abnormal_melanocyte_morpholog1.73714841
31MP0008961_abnormal_basal_metabolism1.71606798
32MP0004133_heterotaxia1.71605283
33MP0002735_abnormal_chemical_nociception1.67576291
34MP0002638_abnormal_pupillary_reflex1.66945277
35MP0003635_abnormal_synaptic_transmissio1.66903926
36MP0005187_abnormal_penis_morphology1.64659258
37MP0006054_spinal_hemorrhage1.63643273
38MP0005645_abnormal_hypothalamus_physiol1.60155650
39MP0008877_abnormal_DNA_methylation1.57420606
40MP0000678_abnormal_parathyroid_gland1.56885875
41* MP0001944_abnormal_pancreas_morphology1.56317457
42MP0002102_abnormal_ear_morphology1.52502837
43MP0009046_muscle_twitch1.51896584
44MP0010386_abnormal_urinary_bladder1.50751390
45MP0002063_abnormal_learning/memory/cond1.48499728
46MP0001986_abnormal_taste_sensitivity1.46305803
47MP0003787_abnormal_imprinting1.45626200
48MP0005167_abnormal_blood-brain_barrier1.42449074
49MP0001968_abnormal_touch/_nociception1.40737180
50MP0000516_abnormal_urinary_system1.40107870
51MP0005367_renal/urinary_system_phenotyp1.40107870
52MP0000537_abnormal_urethra_morphology1.39601905
53MP0001984_abnormal_olfaction1.36326195
54MP0003137_abnormal_impulse_conducting1.35355630
55MP0000778_abnormal_nervous_system1.33641344
56MP0003938_abnormal_ear_development1.32987777
57MP0002064_seizures1.32900924
58MP0001486_abnormal_startle_reflex1.32885112
59MP0002734_abnormal_mechanical_nocicepti1.32593758
60* MP0002693_abnormal_pancreas_physiology1.32490255
61MP0003942_abnormal_urinary_system1.30950464
62MP0000569_abnormal_digit_pigmentation1.30247013
63MP0003880_abnormal_central_pattern1.28143562
64MP0004085_abnormal_heartbeat1.23532600
65MP0001970_abnormal_pain_threshold1.22748734
66MP0005253_abnormal_eye_physiology1.19295777
67MP0004142_abnormal_muscle_tone1.18866679
68MP0004742_abnormal_vestibular_system1.17186173
69MP0002733_abnormal_thermal_nociception1.17005124
70MP0004084_abnormal_cardiac_muscle1.16923480
71MP0001485_abnormal_pinna_reflex1.16840743
72MP0009745_abnormal_behavioral_response1.15415368
73MP0002752_abnormal_somatic_nervous1.15038703
74MP0000955_abnormal_spinal_cord1.14909842
75MP0004924_abnormal_behavior1.14611941
76MP0005386_behavior/neurological_phenoty1.14611941
77MP0002928_abnormal_bile_duct1.13317515
78MP0004811_abnormal_neuron_physiology1.13286057
79MP0003937_abnormal_limbs/digits/tail_de1.12248327
80MP0000049_abnormal_middle_ear1.11705826
81MP0004215_abnormal_myocardial_fiber1.11340575
82MP0002152_abnormal_brain_morphology1.11240835
83MP0003861_abnormal_nervous_system1.10280789
84MP0003123_paternal_imprinting1.09976994
85MP0002067_abnormal_sensory_capabilities1.09207672
86MP0000465_gastrointestinal_hemorrhage1.09166174
87MP0001293_anophthalmia1.09015610
88MP0004043_abnormal_pH_regulation1.08920505
89MP0002938_white_spotting1.08699576
90MP0002557_abnormal_social/conspecific_i1.07980907
91MP0005084_abnormal_gallbladder_morpholo1.07811368
92MP0000026_abnormal_inner_ear1.05928068
93MP0002751_abnormal_autonomic_nervous1.05808970
94MP0002233_abnormal_nose_morphology1.04535483
95MP0001502_abnormal_circadian_rhythm1.04373472
96MP0002653_abnormal_ependyma_morphology1.04236319
97MP0005195_abnormal_posterior_eye1.03827163
98MP0001286_abnormal_eye_development1.03801402
99MP0002572_abnormal_emotion/affect_behav1.02440187
100MP0000534_abnormal_ureter_morphology1.01734011
101MP0002736_abnormal_nociception_after1.01210216
102MP0002837_dystrophic_cardiac_calcinosis1.01194505
103MP0000003_abnormal_adipose_tissue1.00456461
104MP0005391_vision/eye_phenotype1.00398033
105MP0005379_endocrine/exocrine_gland_phen0.99644898
106MP0005220_abnormal_exocrine_pancreas0.99057729
107MP0009278_abnormal_bone_marrow0.98953733
108MP0003136_yellow_coat_color0.98496535
109MP0003567_abnormal_fetal_cardiomyocyte0.97537734
110MP0002697_abnormal_eye_size0.96809111
111MP0009379_abnormal_foot_pigmentation0.96552003
112MP0005174_abnormal_tail_pigmentation0.96115163
113MP0005623_abnormal_meninges_morphology0.95596274
114MP0002184_abnormal_innervation0.95448268
115MP0002163_abnormal_gland_morphology0.94874101
116MP0001440_abnormal_grooming_behavior0.92290244
117MP0006138_congestive_heart_failure0.91805280
118MP0000230_abnormal_systemic_arterial0.90392927
119MP0004270_analgesia0.90197149
120MP0003935_abnormal_craniofacial_develop0.87406007
121MP0001270_distended_abdomen0.87188338
122MP0003315_abnormal_perineum_morphology0.86770907
123MP0003119_abnormal_digestive_system0.85806867
124MP0003755_abnormal_palate_morphology0.85027411
125MP0002396_abnormal_hematopoietic_system0.83768321
126MP0005551_abnormal_eye_electrophysiolog0.83626029
127MP0003011_delayed_dark_adaptation0.82371878
128MP0002160_abnormal_reproductive_system0.81288643
129MP0000681_abnormal_thyroid_gland0.81282531
130MP0001963_abnormal_hearing_physiology0.81199974
131MP0003890_abnormal_embryonic-extraembry0.81183766
132MP0000538_abnormal_urinary_bladder0.78972624
133MP0006276_abnormal_autonomic_nervous0.78924611
134MP0004145_abnormal_muscle_electrophysio0.76174288
135MP0001905_abnormal_dopamine_level0.75314579
136MP0004885_abnormal_endolymph0.74521687
137MP0003172_abnormal_lysosome_physiology0.74346477
138MP0005248_abnormal_Harderian_gland0.73478222
139MP0002925_abnormal_cardiovascular_devel0.73375455
140MP0003300_gastrointestinal_ulcer0.73353192
141MP0002095_abnormal_skin_pigmentation0.73015513
142MP0002272_abnormal_nervous_system0.72733180
143* MP0002081_perinatal_lethality0.72059714
144MP0004036_abnormal_muscle_relaxation0.71846537
145MP0002882_abnormal_neuron_morphology0.71841762
146MP0008569_lethality_at_weaning0.70185200

Predicted human phenotypes

RankGene SetZ-score
1Papilledema (HP:0001085)4.14820669
2Pancreatic fibrosis (HP:0100732)3.48236233
3Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.30205061
4Nephronophthisis (HP:0000090)3.23963995
5Prolonged QT interval (HP:0001657)3.14260125
6Pancreatic cysts (HP:0001737)3.10975245
7Intestinal atresia (HP:0011100)3.07922185
8Visual hallucinations (HP:0002367)3.06888230
9Abnormal pancreas size (HP:0012094)3.01633355
10Medial flaring of the eyebrow (HP:0010747)2.94585944
11Short 4th metacarpal (HP:0010044)2.93252187
12Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.93252187
13Renal duplication (HP:0000075)2.91711454
14Gait imbalance (HP:0002141)2.88139644
15Obsessive-compulsive behavior (HP:0000722)2.87582977
16Hyperventilation (HP:0002883)2.78461683
17Focal motor seizures (HP:0011153)2.77125286
18Limb dystonia (HP:0002451)2.76664313
19Abnormality of the renal medulla (HP:0100957)2.72116578
20Abnormality of the labia minora (HP:0012880)2.70988634
21Severe visual impairment (HP:0001141)2.68921778
22Pendular nystagmus (HP:0012043)2.66994840
23Abnormality of calcium-phosphate metabolism (HP:0100530)2.59711414
24Congenital primary aphakia (HP:0007707)2.59064857
25Macroorchidism (HP:0000053)2.57755657
26Prolonged bleeding time (HP:0003010)2.56250140
27Hyperacusis (HP:0010780)2.54643266
28Abnormal EKG (HP:0003115)2.53771446
29Volvulus (HP:0002580)2.52053684
30Central scotoma (HP:0000603)2.51648332
31Acute lymphatic leukemia (HP:0006721)2.51561488
32Aplastic anemia (HP:0001915)2.48999110
33Genital tract atresia (HP:0001827)2.48826790
34Myokymia (HP:0002411)2.44203557
35Buphthalmos (HP:0000557)2.42924987
36Abnormality of the 4th metacarpal (HP:0010012)2.42612895
37Vaginal atresia (HP:0000148)2.41108126
38Nephrogenic diabetes insipidus (HP:0009806)2.38194282
39Abnormality of the renal cortex (HP:0011035)2.37803377
40Growth hormone excess (HP:0000845)2.34473446
41High anterior hairline (HP:0009890)2.34439479
42Anencephaly (HP:0002323)2.34243317
43Cystic liver disease (HP:0006706)2.34062815
44Pancreatic islet-cell hyperplasia (HP:0004510)2.33976576
45Chronic hepatic failure (HP:0100626)2.33596718
46Abnormality of the aortic arch (HP:0012303)2.33337199
47Absent rod-and cone-mediated responses on ERG (HP:0007688)2.33023388
48Aqueductal stenosis (HP:0002410)2.32673472
49Elfin facies (HP:0004428)2.31703094
50Abnormal rod and cone electroretinograms (HP:0008323)2.31076769
51Oligodactyly (hands) (HP:0001180)2.30982633
52Optic nerve hypoplasia (HP:0000609)2.29645713
53Gastrointestinal atresia (HP:0002589)2.29418917
54Broad-based gait (HP:0002136)2.28909022
55Drooling (HP:0002307)2.27674656
56Agitation (HP:0000713)2.26404639
57Sclerocornea (HP:0000647)2.25800213
58Focal seizures (HP:0007359)2.25121404
59Germ cell neoplasia (HP:0100728)2.20164845
60Lymphangioma (HP:0100764)2.17711087
61Asymmetry of the thorax (HP:0001555)2.15758737
62Polyphagia (HP:0002591)2.10375311
63Poor coordination (HP:0002370)2.09261127
64Congenital glaucoma (HP:0001087)2.09063705
65Hyperinsulinemic hypoglycemia (HP:0000825)2.08794412
66Congenital malformation of the right heart (HP:0011723)2.07489809
67Double outlet right ventricle (HP:0001719)2.07489809
68Postaxial hand polydactyly (HP:0001162)2.06395878
69Postaxial foot polydactyly (HP:0001830)2.04598111
70Preaxial hand polydactyly (HP:0001177)2.03775515
71Hip dysplasia (HP:0001385)2.03110723
72Excessive salivation (HP:0003781)2.02691588
73Febrile seizures (HP:0002373)2.02367730
74Narrow forehead (HP:0000341)2.01784868
75Renal cortical cysts (HP:0000803)2.01266323
76Aplasia/Hypoplasia of the tongue (HP:0010295)2.00322701
77True hermaphroditism (HP:0010459)1.98972095
78Ankyloglossia (HP:0010296)1.98670329
79Abnormality of abdominal situs (HP:0011620)1.98654195
80Abdominal situs inversus (HP:0003363)1.98654195
81Focal segmental glomerulosclerosis (HP:0000097)1.98391626
82Pachygyria (HP:0001302)1.97867485
83Cutaneous finger syndactyly (HP:0010554)1.97243971
84Lissencephaly (HP:0001339)1.96810061
85Megalencephaly (HP:0001355)1.96152889
86Abnormality of macular pigmentation (HP:0008002)1.95945071
87Decreased circulating renin level (HP:0003351)1.95835655
88Oligodactyly (HP:0012165)1.95168276
89Abnormality of the pancreatic islet cells (HP:0006476)1.93610066
90Abnormality of endocrine pancreas physiology (HP:0012093)1.93610066
91Abnormality of the parathyroid morphology (HP:0011766)1.93282072
92Anxiety (HP:0000739)1.92825293
93Anophthalmia (HP:0000528)1.92387523
94Tented upper lip vermilion (HP:0010804)1.91683362
95Tubular atrophy (HP:0000092)1.90583783
96Growth hormone deficiency (HP:0000824)1.89766551
97Septo-optic dysplasia (HP:0100842)1.89023112
98Type II lissencephaly (HP:0007260)1.88493585
99Esophageal atresia (HP:0002032)1.88178969
100Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.87793453
101Transitional cell carcinoma of the bladder (HP:0006740)1.87037978
102Colon cancer (HP:0003003)1.85511064
103Congenital hepatic fibrosis (HP:0002612)1.85332228
104Smooth philtrum (HP:0000319)1.85192687
105Midline defect of the nose (HP:0004122)1.84930804
106Stereotypic behavior (HP:0000733)1.84777386
107Lower limb asymmetry (HP:0100559)1.84151795
108Aplasia/Hypoplasia of the lens (HP:0008063)1.84120325
109Abnormality of the fingertips (HP:0001211)1.84112208
110Scotoma (HP:0000575)1.83909590
111Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.83765085
112Specific learning disability (HP:0001328)1.82579350
113Optic nerve coloboma (HP:0000588)1.82340397
114Labial hypoplasia (HP:0000066)1.82150089
115Hematochezia (HP:0002573)1.81858803
116Hemiparesis (HP:0001269)1.80924215
117Abnormality of the corticospinal tract (HP:0002492)1.80470273
118Hypokalemia (HP:0002900)1.79550087
119Amaurosis fugax (HP:0100576)1.79203408
120Autism (HP:0000717)1.79114345
121Thick eyebrow (HP:0000574)1.78215836
122Progressive cerebellar ataxia (HP:0002073)1.78172015
123Tapered finger (HP:0001182)1.77395485
124Increased corneal curvature (HP:0100692)1.77001597
125Keratoconus (HP:0000563)1.77001597
126Abnormality of the ischium (HP:0003174)1.76534967
127Tubulointerstitial nephritis (HP:0001970)1.76134025
128Large hands (HP:0001176)1.75987716
129Exotropia (HP:0000577)1.75698878
130Abnormal drinking behavior (HP:0030082)1.75522872
131Polydipsia (HP:0001959)1.75522872
132Bladder neoplasm (HP:0009725)1.75364250
133Bladder carcinoma (HP:0002862)1.75364250
134Methylmalonic acidemia (HP:0002912)1.74807334
135Limb hypertonia (HP:0002509)1.74117063
136Testicular neoplasm (HP:0010788)1.72690360
137Congenital stationary night blindness (HP:0007642)1.72496883
138Hypoplastic ischia (HP:0003175)1.72078698
139Dental malocclusion (HP:0000689)1.70648504
140Vitreoretinal degeneration (HP:0000655)1.70500935
141Insulin resistance (HP:0000855)1.70229453
142Annular pancreas (HP:0001734)1.70190323
143Highly arched eyebrow (HP:0002553)1.70161564
144Primary atrial arrhythmia (HP:0001692)1.69804994
145Large for gestational age (HP:0001520)1.69429188
146Mesangial abnormality (HP:0001966)1.69145441
147Heterochromia iridis (HP:0001100)1.68972024
148Insulin-resistant diabetes mellitus (HP:0000831)1.68352920
149Occipital encephalocele (HP:0002085)1.68118412
150Hypercalciuria (HP:0002150)1.67206097
151Abnormality of midbrain morphology (HP:0002418)1.67178314
152Molar tooth sign on MRI (HP:0002419)1.67178314
153Atelectasis (HP:0100750)1.66855629
154Chorioretinal coloboma (HP:0000567)1.66732032
155Type II diabetes mellitus (HP:0005978)1.66680425
156Uterine leiomyosarcoma (HP:0002891)1.66574051
157Leiomyosarcoma (HP:0100243)1.66574051
158Male pseudohermaphroditism (HP:0000037)1.66178295
159Dandy-Walker malformation (HP:0001305)1.65431053
160Short philtrum (HP:0000322)1.64255148
161Attenuation of retinal blood vessels (HP:0007843)1.63915962
162Flat cornea (HP:0007720)1.63163710
163Supraventricular tachycardia (HP:0004755)1.63107069
164Abnormality of the phalanges of the 2nd finger (HP:0009541)1.62626706
165Glucose intolerance (HP:0000833)1.62499301
166Atrial fibrillation (HP:0005110)1.62352964
167Cutaneous syndactyly (HP:0012725)1.62005180
168Supraventricular arrhythmia (HP:0005115)1.61405957
169Hypoplastic labia majora (HP:0000059)1.61238429
170Abolished electroretinogram (ERG) (HP:0000550)1.60827239
171Pointed chin (HP:0000307)1.60683850
172Metaphyseal dysplasia (HP:0100255)1.59960210
173Tubulointerstitial abnormality (HP:0001969)1.59774541
174Amblyopia (HP:0000646)1.59727005
175Hypothermia (HP:0002045)1.59560396
176Hepatoblastoma (HP:0002884)1.59481292
177Renal hypoplasia (HP:0000089)1.59265337
178Cranial hyperostosis (HP:0004437)1.59180858
179Failure to thrive in infancy (HP:0001531)1.58070964
180Abnormality of oral frenula (HP:0000190)1.57772430
181Renal dysplasia (HP:0000110)1.57687144
182Bony spicule pigmentary retinopathy (HP:0007737)1.57539843
183Hypoalbuminemia (HP:0003073)1.57430871
184Abnormal albumin level (HP:0012116)1.57430871

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE14.32700378
2CASK4.23468871
3EPHA33.96450802
4TGFBR13.40644080
5INSRR3.04078454
6CDK82.83565521
7PASK2.68089982
8PNCK2.67652227
9EPHB22.51122053
10MKNK22.41175835
11MAP4K22.31398478
12MKNK12.21244451
13FGFR22.14638068
14PRKD32.12982895
15DYRK22.10347491
16FRK1.92989819
17RIPK41.90541082
18RIPK11.89041257
19EPHA41.88889903
20ERBB31.87312336
21HIPK21.75748470
22UHMK11.71665913
23BRD41.58974068
24MARK11.49512386
25BMPR1B1.49188321
26FES1.45048402
27NTRK31.41927036
28SIK21.41345192
29GRK11.40290699
30RPS6KA21.40054049
31ERBB21.37124190
32TAOK31.35765704
33WNK31.35060814
34PINK11.32457598
35CAMK1G1.31643087
36ADRBK21.30968743
37RPS6KA61.26600689
38TYRO31.26073572
39MAPK131.18502384
40IRAK21.17193013
41CSNK1G21.14561884
42ACVR1B1.14493704
43STK391.14419518
44NUAK11.13712188
45PTK61.13340423
46MAP2K41.12782019
47BCR1.11275597
48PRKCG1.10676019
49KDR1.07171289
50DYRK31.05399497
51PAK31.04388849
52IRAK41.04148138
53TNIK1.02249554
54TGFBR21.02152240
55CSNK1G11.00793399
56ZAK1.00357368
57CDC70.99909805
58KSR10.99392234
59STK38L0.99368403
60YES10.95922482
61TRIM280.95156802
62OXSR10.94910649
63RPS6KC10.91022806
64RPS6KL10.91022806
65PRKCH0.90075894
66PHKG10.88163219
67PHKG20.88163219
68STK110.87465981
69CSNK1G30.85229597
70MARK20.84781344
71CDK190.83935997
72DYRK1A0.82399655
73PKN20.82331399
74SGK20.78388155
75MINK10.78377435
76NLK0.77703493
77WEE10.74192330
78PAK40.73686552
79CAMK1D0.73514421
80WNK40.71935314
81TLK10.71130797
82MUSK0.70558188
83PLK40.66948424
84MAP3K40.65600989
85CDK90.65586273
86PLK20.65379421
87STK160.65088236
88CCNB10.64551765
89DAPK20.64441831
90MELK0.64204206
91RET0.64084544
92CAMKK20.64072807
93PRKD20.63285419
94MAP2K70.63178704
95MAP3K20.62640174
96VRK10.61997189
97MAPK90.61507142
98PIK3CG0.61395100
99CSNK1E0.61388699
100NEK10.61157628
101ALK0.60879073
102FGFR30.60464164
103NEK20.59458307
104CAMKK10.59086535
105IRAK10.59007567
106CSNK1A1L0.58773223
107CDK50.58414387
108STK30.57950686
109BTK0.56136615
110PRKCZ0.55849037
111CAMK2A0.55533327
112MAP3K10.54949850
113TAF10.54339350
114MYLK0.54272568
115NTRK20.53133979
116PRKG10.53047401
117PKN10.52960309
118DYRK1B0.49887103
119SGK30.48075013
120AKT30.47668823
121BRSK10.47538045
122PTK2B0.47157083
123SRPK10.46715408
124CDK30.46599404
125ATR0.46537387
126PRKAA10.46492157
127TRIB30.46007222
128CSNK1D0.45662514
129PRKACB0.45501907
130CAMK40.44885142
131ADRBK10.44495060
132PRKACA0.44006846
133BRSK20.42742165
134SGK2230.42357419
135SGK4940.42357419
136PRKCE0.41862548
137KIT0.41678366
138CAMK10.41350028
139RPS6KA40.41214023
140LATS10.41125419
141RPS6KB10.40814340
142CSNK1A10.39246746
143DAPK10.39112714
144RPS6KA10.38238163
145SGK10.37540600
146AKT10.37424717
147MATK0.36854942
148RPS6KA30.36784954
149CDC42BPA0.35611592
150SIK30.35276920
151MAPK150.35094054
152PLK30.34164470
153PRKG20.34108480
154ILK0.33019222
155MAP2K20.32207069
156GSK3B0.31643444
157EEF2K0.31094583

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.44312238
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.19522641
3Hedgehog signaling pathway_Homo sapiens_hsa043402.02059369
4Basal cell carcinoma_Homo sapiens_hsa052172.00779657
5Circadian entrainment_Homo sapiens_hsa047132.00454048
6Insulin secretion_Homo sapiens_hsa049111.92598827
7Oxidative phosphorylation_Homo sapiens_hsa001901.79099242
8Cocaine addiction_Homo sapiens_hsa050301.73225626
9Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.72845399
10Protein export_Homo sapiens_hsa030601.72015007
11Butanoate metabolism_Homo sapiens_hsa006501.70793490
12Olfactory transduction_Homo sapiens_hsa047401.67292607
13Morphine addiction_Homo sapiens_hsa050321.65479136
14Long-term potentiation_Homo sapiens_hsa047201.63061012
15Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.61761452
16Cholinergic synapse_Homo sapiens_hsa047251.58548638
17Amphetamine addiction_Homo sapiens_hsa050311.57158287
18Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.56706743
19Dopaminergic synapse_Homo sapiens_hsa047281.55845660
20Type II diabetes mellitus_Homo sapiens_hsa049301.54488181
21Parkinsons disease_Homo sapiens_hsa050121.53778618
22N-Glycan biosynthesis_Homo sapiens_hsa005101.45492590
23Aldosterone synthesis and secretion_Homo sapiens_hsa049251.44402144
24Nicotine addiction_Homo sapiens_hsa050331.41892992
25Renin secretion_Homo sapiens_hsa049241.41435319
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.40284764
27GABAergic synapse_Homo sapiens_hsa047271.40099107
28Taste transduction_Homo sapiens_hsa047421.35038299
29Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.32630914
30Carbohydrate digestion and absorption_Homo sapiens_hsa049731.30869056
31Endometrial cancer_Homo sapiens_hsa052131.26357436
32Glutamatergic synapse_Homo sapiens_hsa047241.24474610
33Gap junction_Homo sapiens_hsa045401.24274058
34Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.23822865
35Axon guidance_Homo sapiens_hsa043601.17147283
36Serotonergic synapse_Homo sapiens_hsa047261.16408468
37Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.15255597
38Non-small cell lung cancer_Homo sapiens_hsa052231.14663452
39Platelet activation_Homo sapiens_hsa046111.14037170
40Fanconi anemia pathway_Homo sapiens_hsa034601.11998127
41Oxytocin signaling pathway_Homo sapiens_hsa049211.10665066
42Linoleic acid metabolism_Homo sapiens_hsa005911.09032493
43Propanoate metabolism_Homo sapiens_hsa006401.08631820
44Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.07803762
45cAMP signaling pathway_Homo sapiens_hsa040241.06826834
46cGMP-PKG signaling pathway_Homo sapiens_hsa040221.06155422
47Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.05760062
48alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.05438840
49Dilated cardiomyopathy_Homo sapiens_hsa054141.05165362
50Chronic myeloid leukemia_Homo sapiens_hsa052201.02562939
51Huntingtons disease_Homo sapiens_hsa050161.02496686
52Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.02263673
53Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.00391188
54Nitrogen metabolism_Homo sapiens_hsa009101.00371002
55Alzheimers disease_Homo sapiens_hsa050100.99305674
56Glioma_Homo sapiens_hsa052140.99095738
57Alcoholism_Homo sapiens_hsa050340.97293250
58Tryptophan metabolism_Homo sapiens_hsa003800.96649953
59Phototransduction_Homo sapiens_hsa047440.95923969
60Transcriptional misregulation in cancer_Homo sapiens_hsa052020.95733171
61Hippo signaling pathway_Homo sapiens_hsa043900.95610402
62Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.94738401
63Notch signaling pathway_Homo sapiens_hsa043300.94435875
64Melanogenesis_Homo sapiens_hsa049160.94059528
65Estrogen signaling pathway_Homo sapiens_hsa049150.94036592
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.93687245
67Salivary secretion_Homo sapiens_hsa049700.93665395
68Basal transcription factors_Homo sapiens_hsa030220.92844006
69Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.92318756
70Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.91401583
71mTOR signaling pathway_Homo sapiens_hsa041500.90978385
72Thyroid hormone signaling pathway_Homo sapiens_hsa049190.90457780
73Ether lipid metabolism_Homo sapiens_hsa005650.90050755
74Gastric acid secretion_Homo sapiens_hsa049710.88219044
75Calcium signaling pathway_Homo sapiens_hsa040200.86811693
76mRNA surveillance pathway_Homo sapiens_hsa030150.86799631
77SNARE interactions in vesicular transport_Homo sapiens_hsa041300.86118752
78Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.85531135
79Circadian rhythm_Homo sapiens_hsa047100.85093736
80Long-term depression_Homo sapiens_hsa047300.84733862
81Vascular smooth muscle contraction_Homo sapiens_hsa042700.83614483
82Oocyte meiosis_Homo sapiens_hsa041140.82994083
83Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.82983744
84Regulation of autophagy_Homo sapiens_hsa041400.82803632
85Prolactin signaling pathway_Homo sapiens_hsa049170.82089355
86Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.81748824
87Rap1 signaling pathway_Homo sapiens_hsa040150.81109688
88Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.79945733
89Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.78812505
90Pancreatic secretion_Homo sapiens_hsa049720.78797867
91AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.78773737
92GnRH signaling pathway_Homo sapiens_hsa049120.77382824
93Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.76984051
94Wnt signaling pathway_Homo sapiens_hsa043100.76361516
95Ovarian steroidogenesis_Homo sapiens_hsa049130.75756991
96Colorectal cancer_Homo sapiens_hsa052100.75220783
97MAPK signaling pathway_Homo sapiens_hsa040100.74944567
98Insulin resistance_Homo sapiens_hsa049310.73155664
99Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.73140490
100Bladder cancer_Homo sapiens_hsa052190.72711831
101Synaptic vesicle cycle_Homo sapiens_hsa047210.72045496
102Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.71334969
103Dorso-ventral axis formation_Homo sapiens_hsa043200.71050828
104RNA degradation_Homo sapiens_hsa030180.70991510
105Phosphatidylinositol signaling system_Homo sapiens_hsa040700.70631026
106Focal adhesion_Homo sapiens_hsa045100.69347984
107Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.67953537
108Collecting duct acid secretion_Homo sapiens_hsa049660.66990271
109Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.65324528
110Small cell lung cancer_Homo sapiens_hsa052220.65084346
111Thyroid hormone synthesis_Homo sapiens_hsa049180.64570257
112Lysine degradation_Homo sapiens_hsa003100.63494782
113Retinol metabolism_Homo sapiens_hsa008300.63489979
114FoxO signaling pathway_Homo sapiens_hsa040680.61925600
115Cardiac muscle contraction_Homo sapiens_hsa042600.61385434
116Peroxisome_Homo sapiens_hsa041460.61248439
117Pancreatic cancer_Homo sapiens_hsa052120.60602307
118Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.60583869
119VEGF signaling pathway_Homo sapiens_hsa043700.60375358
120Glucagon signaling pathway_Homo sapiens_hsa049220.60295572
121Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.59602780
122ABC transporters_Homo sapiens_hsa020100.59237880
123TGF-beta signaling pathway_Homo sapiens_hsa043500.58611740
124Steroid hormone biosynthesis_Homo sapiens_hsa001400.58320011
125Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.57280738
126Choline metabolism in cancer_Homo sapiens_hsa052310.56386618
127Thyroid cancer_Homo sapiens_hsa052160.56321714
128Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.56110153
129Insulin signaling pathway_Homo sapiens_hsa049100.56005780
130MicroRNAs in cancer_Homo sapiens_hsa052060.55012083
131Chemokine signaling pathway_Homo sapiens_hsa040620.54963942
132Renal cell carcinoma_Homo sapiens_hsa052110.54623599
133Pathways in cancer_Homo sapiens_hsa052000.53500587
134Cell cycle_Homo sapiens_hsa041100.52686508
135Phospholipase D signaling pathway_Homo sapiens_hsa040720.52406329
136Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.51913576
137Spliceosome_Homo sapiens_hsa030400.51126565
138Acute myeloid leukemia_Homo sapiens_hsa052210.50885712
139Tight junction_Homo sapiens_hsa045300.48311461
140Glycerolipid metabolism_Homo sapiens_hsa005610.47360301
141Primary bile acid biosynthesis_Homo sapiens_hsa001200.45826352
142Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.44986714
143Protein digestion and absorption_Homo sapiens_hsa049740.42142983
144Caffeine metabolism_Homo sapiens_hsa002320.41403458
145Chemical carcinogenesis_Homo sapiens_hsa052040.39882000
146Steroid biosynthesis_Homo sapiens_hsa001000.36871696
147Ras signaling pathway_Homo sapiens_hsa040140.36833266

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »