DACH2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is one of two genes which encode a protein similar to the Drosophila protein dachshund, a transcription factor involved in cell fate determination in the eye, limb and genital disc of the fly. The encoded protein contains two characteristic dachshund domains: an N-terminal domain responsible for DNA binding and a C-terminal domain responsible for protein-protein interactions. This gene is located on the X chromosome and is subject to inactivation by DNA methylation. The encoded protein may be involved in regulation of organogenesis and myogenesis, and may play a role in premature ovarian failure. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1daunorubicin metabolic process (GO:0044597)7.39549217
2polyketide metabolic process (GO:0030638)7.39549217
3doxorubicin metabolic process (GO:0044598)7.39549217
4pyrimidine nucleobase catabolic process (GO:0006208)5.30114494
5response to pheromone (GO:0019236)5.09557708
6vocalization behavior (GO:0071625)5.00800881
7postsynaptic membrane organization (GO:0001941)4.94935902
8neuron cell-cell adhesion (GO:0007158)4.76450627
9gamma-aminobutyric acid transport (GO:0015812)4.76157800
10aminoglycoside antibiotic metabolic process (GO:0030647)4.44564275
11protein localization to synapse (GO:0035418)4.21602174
12presynaptic membrane assembly (GO:0097105)4.12664766
13regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.08575182
14central nervous system projection neuron axonogenesis (GO:0021952)3.87695255
15behavioral response to nicotine (GO:0035095)3.84479313
16presynaptic membrane organization (GO:0097090)3.82085997
17dendritic spine morphogenesis (GO:0060997)3.80142698
18synaptic vesicle maturation (GO:0016188)3.65170752
19synaptic vesicle docking involved in exocytosis (GO:0016081)3.62492281
20exploration behavior (GO:0035640)3.61220577
21nucleobase catabolic process (GO:0046113)3.59027754
22negative regulation of cytosolic calcium ion concentration (GO:0051481)3.53595736
23auditory behavior (GO:0031223)3.53359897
24neuronal action potential propagation (GO:0019227)3.49832478
25membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.47736918
26neurotransmitter secretion (GO:0007269)3.44508073
27regulation of short-term neuronal synaptic plasticity (GO:0048172)3.42529866
28regulation of synapse structural plasticity (GO:0051823)3.41132231
29mechanosensory behavior (GO:0007638)3.41013013
30neuron recognition (GO:0008038)3.39874806
31cerebral cortex radially oriented cell migration (GO:0021799)3.34038538
32positive regulation of synapse assembly (GO:0051965)3.31822250
33axonal fasciculation (GO:0007413)3.28872313
34protein localization to microtubule (GO:0035372)3.28803677
35protein localization to cilium (GO:0061512)3.28070749
36dendrite development (GO:0016358)3.24650575
37opioid receptor signaling pathway (GO:0038003)3.17436948
38response to auditory stimulus (GO:0010996)3.16265775
39locomotory exploration behavior (GO:0035641)3.15089269
40positive regulation of neurotransmitter secretion (GO:0001956)3.15025212
41regulation of glutamate receptor signaling pathway (GO:1900449)3.14674076
42membrane depolarization during action potential (GO:0086010)3.13182398
43positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.09902262
44regulation of cAMP-dependent protein kinase activity (GO:2000479)3.09654615
45regulation of synapse maturation (GO:0090128)3.07603873
46regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.02297087
47neurofilament cytoskeleton organization (GO:0060052)3.01552365
48synaptic vesicle exocytosis (GO:0016079)2.94344583
49cell differentiation involved in metanephros development (GO:0072202)2.93686698
50generation of neurons (GO:0048699)2.92258606
51startle response (GO:0001964)2.92233762
52regulation of synaptic vesicle exocytosis (GO:2000300)2.90595297
53central nervous system neuron axonogenesis (GO:0021955)2.90357655
54neurotransmitter-gated ion channel clustering (GO:0072578)2.90167714
55glycosphingolipid biosynthetic process (GO:0006688)2.87705437
56layer formation in cerebral cortex (GO:0021819)2.87175102
57neuronal action potential (GO:0019228)2.87098052
58adult walking behavior (GO:0007628)2.84220013
59regulation of synapse assembly (GO:0051963)2.82584258
60regulation of vesicle fusion (GO:0031338)2.82350693
61DNA ligation (GO:0006266)2.81120387
62G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.79979178
63fucose catabolic process (GO:0019317)2.76787712
64L-fucose metabolic process (GO:0042354)2.76787712
65L-fucose catabolic process (GO:0042355)2.76787712
66synaptic transmission, glutamatergic (GO:0035249)2.76683577
67short-term memory (GO:0007614)2.76439584
68synapse assembly (GO:0007416)2.75311499
69regulation of neurotransmitter levels (GO:0001505)2.74913379
70positive regulation of membrane potential (GO:0045838)2.74522854
71positive regulation of neurotransmitter transport (GO:0051590)2.73734830
72positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.72995263
73regulation of synaptic transmission, glutamatergic (GO:0051966)2.72556600
74protein localization to microtubule cytoskeleton (GO:0072698)2.70732696
75positive regulation of filopodium assembly (GO:0051491)2.70502448
76epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.69499435
77regulation of neurotransmitter uptake (GO:0051580)2.69438623
78nonmotile primary cilium assembly (GO:0035058)2.68953506
79dentate gyrus development (GO:0021542)2.68336302
80positive regulation of synaptic transmission, GABAergic (GO:0032230)2.67547170
81intraciliary transport (GO:0042073)2.67470177
82behavioral fear response (GO:0001662)2.67299100
83behavioral defense response (GO:0002209)2.67299100
84regulation of postsynaptic membrane potential (GO:0060078)2.66958710
85neurotransmitter transport (GO:0006836)2.66829360
86energy homeostasis (GO:0097009)2.66360130
87microtubule depolymerization (GO:0007019)2.66344558
88neuromuscular synaptic transmission (GO:0007274)2.65822378
89inner ear receptor stereocilium organization (GO:0060122)2.65707004
90kidney morphogenesis (GO:0060993)2.64759993
91lateral ventricle development (GO:0021670)2.63655342
92retinal ganglion cell axon guidance (GO:0031290)2.63387449
93regulation of voltage-gated calcium channel activity (GO:1901385)2.63086503
94synapse organization (GO:0050808)2.62449634
95transmission of nerve impulse (GO:0019226)2.61479967
96cell migration in hindbrain (GO:0021535)2.61468242
97gamma-aminobutyric acid signaling pathway (GO:0007214)2.59910234
98establishment of mitochondrion localization (GO:0051654)2.59841821
99positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.59306525
100peristalsis (GO:0030432)2.58527729
101synaptic transmission (GO:0007268)2.57613958
102regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.57330046
103regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.57330046
104neuronal ion channel clustering (GO:0045161)2.56674880
105membrane depolarization (GO:0051899)2.56277709
106glutamate receptor signaling pathway (GO:0007215)2.56260574
107regulation of excitatory postsynaptic membrane potential (GO:0060079)2.56121226
108neuron migration (GO:0001764)2.55696566
109regulation of synapse organization (GO:0050807)2.55513659
110righting reflex (GO:0060013)2.54969953
111protein localization to cytoskeleton (GO:0044380)2.54593592
112urinary tract smooth muscle contraction (GO:0014848)2.54274954
113retina layer formation (GO:0010842)2.54183762
114regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.53978523
115cAMP catabolic process (GO:0006198)2.53922197
116cellular ketone body metabolic process (GO:0046950)2.51429551
117limb bud formation (GO:0060174)2.51365374
118behavioral response to ethanol (GO:0048149)2.50782254
119negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.49823862
120adult behavior (GO:0030534)2.49509756
121positive regulation of vesicle fusion (GO:0031340)2.48726385
122regulation of timing of cell differentiation (GO:0048505)2.48574088
123mesenchymal cell differentiation involved in renal system development (GO:2001012)2.48482319
124mesenchymal cell differentiation involved in kidney development (GO:0072161)2.48482319
125primary amino compound metabolic process (GO:1901160)2.48231467
126regulation of neurotransmitter transport (GO:0051588)2.48021937
127calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.47208345
128cerebellum development (GO:0021549)2.46729294
129ionotropic glutamate receptor signaling pathway (GO:0035235)2.46151374
130metanephric mesenchyme development (GO:0072075)2.45940980
131cell differentiation involved in kidney development (GO:0061005)2.45420969
132innervation (GO:0060384)2.44530209
133regulation of synaptic vesicle transport (GO:1902803)2.43693297
134dendrite morphogenesis (GO:0048813)2.42500545
135negative regulation of meiosis (GO:0045835)2.41378288
136glutamate secretion (GO:0014047)2.41324552
137negative regulation of synaptic transmission, GABAergic (GO:0032229)2.41289171
138prostate gland growth (GO:0060736)2.39304126
139epithelial cell differentiation involved in kidney development (GO:0035850)2.37168403
140mitochondrion transport along microtubule (GO:0047497)2.35377262
141establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.35377262
142regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.34608388
143neuron-neuron synaptic transmission (GO:0007270)2.33710199
144cochlea development (GO:0090102)2.32653701
145serotonin receptor signaling pathway (GO:0007210)2.32217929
146forebrain neuron differentiation (GO:0021879)2.31263901
147cAMP-mediated signaling (GO:0019933)2.30312152
148positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.28997007
149positive regulation of dendritic spine morphogenesis (GO:0061003)2.27941395
150vesicle docking involved in exocytosis (GO:0006904)2.26507561

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.52705789
2GBX2_23144817_ChIP-Seq_PC3_Human4.12572310
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.47564370
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.06449732
5EZH2_27304074_Chip-Seq_ESCs_Mouse2.61978817
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.55303148
7IGF1R_20145208_ChIP-Seq_DFB_Human2.44355665
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.37383474
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.36369621
10EED_16625203_ChIP-ChIP_MESCs_Mouse2.34273463
11BMI1_23680149_ChIP-Seq_NPCS_Mouse2.33972254
12* CBX2_27304074_Chip-Seq_ESCs_Mouse2.33531266
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.32121800
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.23538918
15TAF15_26573619_Chip-Seq_HEK293_Human2.22546026
16SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.19786973
17JARID2_20075857_ChIP-Seq_MESCs_Mouse2.12020316
18CTBP2_25329375_ChIP-Seq_LNCAP_Human2.09866426
19SMAD_19615063_ChIP-ChIP_OVARY_Human2.08804663
20FUS_26573619_Chip-Seq_HEK293_Human2.08743469
21P300_19829295_ChIP-Seq_ESCs_Human2.06891539
22CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.04895277
23RNF2_27304074_Chip-Seq_NSC_Mouse2.03829167
24SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.97599060
25EZH2_18974828_ChIP-Seq_MESCs_Mouse1.92175979
26RNF2_18974828_ChIP-Seq_MESCs_Mouse1.92175979
27VDR_22108803_ChIP-Seq_LS180_Human1.92121954
28RNF2_27304074_Chip-Seq_ESCs_Mouse1.89846441
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.88991261
30EZH2_27294783_Chip-Seq_ESCs_Mouse1.83432951
31SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.81747744
32PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.79573845
33SUZ12_27294783_Chip-Seq_ESCs_Mouse1.77541980
34PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.76997269
35REST_21632747_ChIP-Seq_MESCs_Mouse1.76277985
36AR_21572438_ChIP-Seq_LNCaP_Human1.72494566
37ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.72193712
38EWS_26573619_Chip-Seq_HEK293_Human1.71382606
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.67659418
40RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.67548461
41PCGF2_27294783_Chip-Seq_ESCs_Mouse1.64813600
42SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.63581780
43CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.63081195
44SMAD3_21741376_ChIP-Seq_EPCs_Human1.62506257
45MTF2_20144788_ChIP-Seq_MESCs_Mouse1.60577441
46OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.60179297
47NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.56687143
48RBPJ_22232070_ChIP-Seq_NCS_Mouse1.55293499
49SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.54933400
50POU5F1_16153702_ChIP-ChIP_HESCs_Human1.52603486
51TOP2B_26459242_ChIP-Seq_MCF-7_Human1.52003417
52SMAD4_21799915_ChIP-Seq_A2780_Human1.49524654
53FLI1_27457419_Chip-Seq_LIVER_Mouse1.49486424
54P53_22127205_ChIP-Seq_FIBROBLAST_Human1.48204394
55CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.47935122
56TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.47516662
57DROSHA_22980978_ChIP-Seq_HELA_Human1.45990675
58MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.42707513
59NANOG_18555785_Chip-Seq_ESCs_Mouse1.42028414
60EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.41048191
61SUZ12_27294783_Chip-Seq_NPCs_Mouse1.40987563
62MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.38757646
63PIAS1_25552417_ChIP-Seq_VCAP_Human1.38120832
64PCGF2_27294783_Chip-Seq_NPCs_Mouse1.37705343
65SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37626798
66AR_25329375_ChIP-Seq_VCAP_Human1.35134120
67TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34958982
68POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.34958982
69TP63_19390658_ChIP-ChIP_HaCaT_Human1.34556257
70E2F1_18555785_Chip-Seq_ESCs_Mouse1.32186502
71CBP_20019798_ChIP-Seq_JUKART_Human1.31437931
72IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.31437931
73TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.31410912
74SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30911078
75SUZ12_18555785_Chip-Seq_ESCs_Mouse1.28242046
76NFE2_27457419_Chip-Seq_LIVER_Mouse1.27122194
77P53_22387025_ChIP-Seq_ESCs_Mouse1.26546106
78ER_23166858_ChIP-Seq_MCF-7_Human1.25209164
79REST_18959480_ChIP-ChIP_MESCs_Mouse1.24511971
80NR3C1_21868756_ChIP-Seq_MCF10A_Human1.23616883
81BCAT_22108803_ChIP-Seq_LS180_Human1.23374037
82CMYC_18555785_Chip-Seq_ESCs_Mouse1.22568044
83JUN_21703547_ChIP-Seq_K562_Human1.19986872
84HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.18646694
85STAT3_18555785_Chip-Seq_ESCs_Mouse1.18569712
86TCF4_23295773_ChIP-Seq_U87_Human1.18351068
87KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18043606
88MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.17743342
89FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.17001507
90AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.15797892
91STAT3_23295773_ChIP-Seq_U87_Human1.15487462
92* TP53_22573176_ChIP-Seq_HFKS_Human1.14512994
93GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.14337556
94* SOX2_21211035_ChIP-Seq_LN229_Gbm1.14129762
95TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13647714
96EZH2_27294783_Chip-Seq_NPCs_Mouse1.13574358
97NMYC_18555785_Chip-Seq_ESCs_Mouse1.12645463
98IRF1_19129219_ChIP-ChIP_H3396_Human1.12015989
99* RUNX2_22187159_ChIP-Seq_PCA_Human1.11275467
100P300_18555785_Chip-Seq_ESCs_Mouse1.10539752
101RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.10367204
102RING1B_27294783_Chip-Seq_NPCs_Mouse1.09836756
103SALL1_21062744_ChIP-ChIP_HESCs_Human1.09485117
104EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.09080086
105YAP1_20516196_ChIP-Seq_MESCs_Mouse1.08266729
106UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08201883
107ZNF274_21170338_ChIP-Seq_K562_Hela1.07748781
108TAL1_26923725_Chip-Seq_HPCs_Mouse1.07396201
109PRDM14_20953172_ChIP-Seq_ESCs_Human1.06362492
110KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.05267435
111SOX2_18555785_Chip-Seq_ESCs_Mouse1.04942959
112FLI1_21867929_ChIP-Seq_TH2_Mouse1.04882740
113RING1B_27294783_Chip-Seq_ESCs_Mouse1.04794389
114TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03875659
115RUNX1_27457419_Chip-Seq_LIVER_Mouse1.03657670
116TCF4_22108803_ChIP-Seq_LS180_Human1.00906172
117RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.99573885
118ETV2_25802403_ChIP-Seq_MESCs_Mouse0.98502796
119LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97795271
120* NANOG_19829295_ChIP-Seq_ESCs_Human0.95860988

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.18480930
2MP0005423_abnormal_somatic_nervous2.90293111
3MP0006276_abnormal_autonomic_nervous2.80390275
4MP0002822_catalepsy2.75437321
5MP0004859_abnormal_synaptic_plasticity2.73512558
6MP0006292_abnormal_olfactory_placode2.69709997
7MP0005645_abnormal_hypothalamus_physiol2.66104105
8MP0001188_hyperpigmentation2.49668416
9MP0000778_abnormal_nervous_system2.35172509
10MP0000566_synostosis2.33370674
11MP0009697_abnormal_copulation2.27872117
12MP0001486_abnormal_startle_reflex2.21339066
13MP0002735_abnormal_chemical_nociception2.18564090
14MP0003635_abnormal_synaptic_transmissio2.14677282
15MP0002734_abnormal_mechanical_nocicepti2.13118833
16MP0001968_abnormal_touch/_nociception2.04505652
17MP0002063_abnormal_learning/memory/cond1.98252670
18MP0002557_abnormal_social/conspecific_i1.91408211
19MP0002102_abnormal_ear_morphology1.89327597
20MP0002938_white_spotting1.85512161
21MP0002837_dystrophic_cardiac_calcinosis1.82239620
22MP0008877_abnormal_DNA_methylation1.80778985
23MP0004270_analgesia1.80409794
24MP0002572_abnormal_emotion/affect_behav1.80409055
25MP0002184_abnormal_innervation1.78679445
26MP0009745_abnormal_behavioral_response1.78673807
27MP0005646_abnormal_pituitary_gland1.78317758
28MP0003787_abnormal_imprinting1.70834622
29MP0002736_abnormal_nociception_after1.69321989
30MP0003122_maternal_imprinting1.65227498
31MP0005499_abnormal_olfactory_system1.64567800
32MP0005394_taste/olfaction_phenotype1.64567800
33MP0002909_abnormal_adrenal_gland1.63203559
34MP0000631_abnormal_neuroendocrine_gland1.60816166
35MP0000678_abnormal_parathyroid_gland1.51315422
36MP0009780_abnormal_chondrocyte_physiolo1.50423628
37MP0002638_abnormal_pupillary_reflex1.50153417
38MP0001502_abnormal_circadian_rhythm1.48515585
39MP0004133_heterotaxia1.46962085
40MP0003879_abnormal_hair_cell1.45292893
41MP0001984_abnormal_olfaction1.44398530
42MP0010386_abnormal_urinary_bladder1.42850457
43MP0005171_absent_coat_pigmentation1.42219584
44MP0004134_abnormal_chest_morphology1.41643410
45MP0004885_abnormal_endolymph1.40152431
46MP0000049_abnormal_middle_ear1.38987901
47MP0002064_seizures1.38417032
48MP0005409_darkened_coat_color1.37307645
49MP0003136_yellow_coat_color1.36676197
50MP0006072_abnormal_retinal_apoptosis1.36322620
51MP0001348_abnormal_lacrimal_gland1.35424879
52MP0008004_abnormal_stomach_pH1.33207801
53MP0001970_abnormal_pain_threshold1.31143435
54MP0002067_abnormal_sensory_capabilities1.30913757
55MP0004147_increased_porphyrin_level1.30689883
56MP0001986_abnormal_taste_sensitivity1.30114336
57MP0002733_abnormal_thermal_nociception1.29561598
58MP0003941_abnormal_skin_development1.27182151
59MP0001529_abnormal_vocalization1.25773924
60MP0001440_abnormal_grooming_behavior1.25221449
61MP0000015_abnormal_ear_pigmentation1.24596042
62MP0005386_behavior/neurological_phenoty1.24436409
63MP0004924_abnormal_behavior1.24436409
64MP0005551_abnormal_eye_electrophysiolog1.24412600
65MP0003646_muscle_fatigue1.24258044
66MP0002095_abnormal_skin_pigmentation1.23560758
67MP0001485_abnormal_pinna_reflex1.22240386
68MP0001177_atelectasis1.20578285
69MP0000955_abnormal_spinal_cord1.20570298
70MP0000569_abnormal_digit_pigmentation1.17899009
71MP0002751_abnormal_autonomic_nervous1.17849748
72MP0005379_endocrine/exocrine_gland_phen1.17783257
73MP0004145_abnormal_muscle_electrophysio1.17037153
74MP0003385_abnormal_body_wall1.14871543
75MP0003942_abnormal_urinary_system1.14434361
76MP0001963_abnormal_hearing_physiology1.14129036
77MP0004811_abnormal_neuron_physiology1.14119713
78MP0000026_abnormal_inner_ear1.13778387
79MP0002882_abnormal_neuron_morphology1.13353248
80MP0005187_abnormal_penis_morphology1.11775028
81MP0008872_abnormal_physiological_respon1.11134084
82MP0004742_abnormal_vestibular_system1.10876785
83MP0001905_abnormal_dopamine_level1.10735416
84MP0002272_abnormal_nervous_system1.10028302
85MP0003121_genomic_imprinting1.10016435
86MP0009046_muscle_twitch1.08281404
87MP0003119_abnormal_digestive_system1.07996511
88MP0008995_early_reproductive_senescence1.07098238
89MP0005248_abnormal_Harderian_gland1.05484138
90MP0004043_abnormal_pH_regulation1.05113498
91MP0009250_abnormal_appendicular_skeleto1.04777034
92MP0002752_abnormal_somatic_nervous1.04468889
93MP0003011_delayed_dark_adaptation1.03335330
94MP0003890_abnormal_embryonic-extraembry1.02234198
95MP0008789_abnormal_olfactory_epithelium1.01615032
96MP0001501_abnormal_sleep_pattern0.99836819
97MP0003283_abnormal_digestive_organ0.99348288
98MP0005253_abnormal_eye_physiology0.97667165
99MP0005174_abnormal_tail_pigmentation0.97476511
100MP0003633_abnormal_nervous_system0.97124399
101MP0001664_abnormal_digestion0.96940682
102MP0001346_abnormal_lacrimal_gland0.96886112
103MP0003137_abnormal_impulse_conducting0.96636133
104MP0002152_abnormal_brain_morphology0.93059366
105MP0002653_abnormal_ependyma_morphology0.92582074
106MP0009379_abnormal_foot_pigmentation0.92199590
107MP0000681_abnormal_thyroid_gland0.91882834
108MP0003195_calcinosis0.91807027
109MP0002229_neurodegeneration0.91659089
110MP0003938_abnormal_ear_development0.91208097
111MP0002876_abnormal_thyroid_physiology0.90649973
112MP0002069_abnormal_eating/drinking_beha0.89156214
113MP0001324_abnormal_eye_pigmentation0.89069323
114MP0003755_abnormal_palate_morphology0.88731681
115MP0008569_lethality_at_weaning0.87271875
116MP0002234_abnormal_pharynx_morphology0.87171900
117MP0005195_abnormal_posterior_eye0.86417364
118MP0008058_abnormal_DNA_repair0.84056555
119MP0002066_abnormal_motor_capabilities/c0.83918605
120MP0003878_abnormal_ear_physiology0.82303029
121MP0005377_hearing/vestibular/ear_phenot0.82303029
122MP0002160_abnormal_reproductive_system0.80643450
123MP0004142_abnormal_muscle_tone0.80193957
124MP0000372_irregular_coat_pigmentation0.79868409
125MP0003861_abnormal_nervous_system0.79803761
126MP0004782_abnormal_surfactant_physiolog0.79182485
127MP0002116_abnormal_craniofacial_bone0.78942574
128MP0002928_abnormal_bile_duct0.76338622
129MP0003631_nervous_system_phenotype0.71202448
130MP0005084_abnormal_gallbladder_morpholo0.70179236
131MP0001293_anophthalmia0.68287799

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)4.48475520
2Abnormal ciliary motility (HP:0012262)4.01836879
3Parakeratosis (HP:0001036)3.93507500
4True hermaphroditism (HP:0010459)3.61526288
5Abnormal respiratory epithelium morphology (HP:0012253)3.48698392
6Abnormal respiratory motile cilium morphology (HP:0005938)3.48698392
7Absent/shortened dynein arms (HP:0200106)3.44283501
8Dynein arm defect of respiratory motile cilia (HP:0012255)3.44283501
9Gait imbalance (HP:0002141)3.37265853
10Epileptic encephalopathy (HP:0200134)3.20624903
11Abnormality of the labia minora (HP:0012880)3.05148519
12Abnormal respiratory motile cilium physiology (HP:0012261)2.97463578
13Medial flaring of the eyebrow (HP:0010747)2.86725209
14Nephronophthisis (HP:0000090)2.85158515
15Atonic seizures (HP:0010819)2.80693457
16Febrile seizures (HP:0002373)2.80045667
17Protruding tongue (HP:0010808)2.77523119
18Nephrogenic diabetes insipidus (HP:0009806)2.68303453
19Type II lissencephaly (HP:0007260)2.66534922
20Septo-optic dysplasia (HP:0100842)2.64647543
21Epileptiform EEG discharges (HP:0011182)2.64395318
22Broad-based gait (HP:0002136)2.63252751
23Generalized tonic-clonic seizures (HP:0002069)2.62708849
24Hyperventilation (HP:0002883)2.60429486
25EEG with generalized epileptiform discharges (HP:0011198)2.57918248
26Hypsarrhythmia (HP:0002521)2.57527973
27Congenital primary aphakia (HP:0007707)2.54353954
28Pancreatic fibrosis (HP:0100732)2.51194021
29Dialeptic seizures (HP:0011146)2.48836179
30Absent eyebrow (HP:0002223)2.47500058
31Agitation (HP:0000713)2.47480846
32Thyroid-stimulating hormone excess (HP:0002925)2.45892905
33Lissencephaly (HP:0001339)2.43652603
34Hemiparesis (HP:0001269)2.40524898
35Hypoplasia of the fovea (HP:0007750)2.39553324
36Aplasia/Hypoplasia of the fovea (HP:0008060)2.39553324
37Flat cornea (HP:0007720)2.38903088
38Abnormal hair whorl (HP:0010721)2.34848272
39Limb dystonia (HP:0002451)2.32958272
40Gaze-evoked nystagmus (HP:0000640)2.28851894
41Abnormality of the renal medulla (HP:0100957)2.28469311
42Abnormal eating behavior (HP:0100738)2.27214989
43Retinal dysplasia (HP:0007973)2.25195937
44Optic nerve hypoplasia (HP:0000609)2.23432335
45Renal duplication (HP:0000075)2.22254903
46Aplasia/Hypoplasia of the lens (HP:0008063)2.22090094
47Amyotrophic lateral sclerosis (HP:0007354)2.21873531
48Polyphagia (HP:0002591)2.19771120
49Cystic liver disease (HP:0006706)2.18818765
50Pancreatic cysts (HP:0001737)2.17009209
51Akinesia (HP:0002304)2.16753293
52Spastic tetraplegia (HP:0002510)2.16156152
53Absence seizures (HP:0002121)2.13756478
54Molar tooth sign on MRI (HP:0002419)2.13142258
55Abnormality of midbrain morphology (HP:0002418)2.13142258
56Inappropriate behavior (HP:0000719)2.12110493
57Rimmed vacuoles (HP:0003805)2.11620871
58Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.11534461
59Excessive salivation (HP:0003781)2.11150347
60Drooling (HP:0002307)2.11150347
61Focal motor seizures (HP:0011153)2.10658717
62Congenital sensorineural hearing impairment (HP:0008527)2.09788060
63Blue irides (HP:0000635)2.09202238
64Inability to walk (HP:0002540)2.06448783
65Hypothermia (HP:0002045)2.06122995
66Increased hepatocellular lipid droplets (HP:0006565)2.05730530
67Aplasia/Hypoplasia of the tibia (HP:0005772)2.05570375
68Unilateral renal agenesis (HP:0000122)2.05334931
69Lipid accumulation in hepatocytes (HP:0006561)2.05305092
70Fair hair (HP:0002286)2.04366352
71Fetal akinesia sequence (HP:0001989)2.04156234
72Mutism (HP:0002300)2.04019247
73Pachygyria (HP:0001302)2.03878332
74Abnormality of the corticospinal tract (HP:0002492)2.03545340
75Generalized hypopigmentation of hair (HP:0011358)2.02058698
76Acute necrotizing encephalopathy (HP:0006965)1.97943721
77Absent eyelashes (HP:0000561)1.97302229
78Prostate neoplasm (HP:0100787)1.96439885
79Progressive cerebellar ataxia (HP:0002073)1.96106343
80Action tremor (HP:0002345)1.96011241
81Shoulder girdle muscle weakness (HP:0003547)1.95243307
82Cutaneous syndactyly (HP:0012725)1.94774418
83Genetic anticipation (HP:0003743)1.94334784
84Intestinal atresia (HP:0011100)1.93025682
85Anencephaly (HP:0002323)1.92889700
86Abnormality of the phalanges of the 5th finger (HP:0004213)1.90809827
87Vaginal atresia (HP:0000148)1.90659006
88Genital tract atresia (HP:0001827)1.90549541
89Broad foot (HP:0001769)1.89925447
90Mitochondrial inheritance (HP:0001427)1.89593108
91Absent hair (HP:0002298)1.89019780
92Sleep apnea (HP:0010535)1.88460194
93Amblyopia (HP:0000646)1.88343333
94Sclerocornea (HP:0000647)1.88323879
95Narrow forehead (HP:0000341)1.87709956
96Progressive macrocephaly (HP:0004481)1.86334200
97Cutaneous finger syndactyly (HP:0010554)1.84794376
98Abnormality of incisor morphology (HP:0011063)1.83718443
99Decreased central vision (HP:0007663)1.83412145
100Decreased circulating renin level (HP:0003351)1.83275285
101Abnormality of dental color (HP:0011073)1.82916339
102Abnormality of the renal cortex (HP:0011035)1.82732849
103Status epilepticus (HP:0002133)1.82108164
104Abnormality of the fovea (HP:0000493)1.82060707
105Humeroradial synostosis (HP:0003041)1.81892697
106Synostosis involving the elbow (HP:0003938)1.81892697
107Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.81698086
108Degeneration of the lateral corticospinal tracts (HP:0002314)1.81698086
109Abnormality of calcium-phosphate metabolism (HP:0100530)1.81468378
110Aplasia/Hypoplasia of the brainstem (HP:0007362)1.80656775
111Hypoplasia of the brainstem (HP:0002365)1.80656775
112Anxiety (HP:0000739)1.80604793
113Dysdiadochokinesis (HP:0002075)1.80312421
114Muscular hypotonia of the trunk (HP:0008936)1.80095998
115Abnormality of the metopic suture (HP:0005556)1.79423835
116Abolished electroretinogram (ERG) (HP:0000550)1.79249499
117Abnormal drinking behavior (HP:0030082)1.79063206
118Polydipsia (HP:0001959)1.79063206
119Increased corneal curvature (HP:0100692)1.78431554
120Keratoconus (HP:0000563)1.78431554
121Hyperacusis (HP:0010780)1.78137171
122Postaxial hand polydactyly (HP:0001162)1.78089433
123Bifid tongue (HP:0010297)1.77881867
124Absent septum pellucidum (HP:0001331)1.77546995
125Overriding aorta (HP:0002623)1.77372483
126Aplasia/Hypoplasia of the tongue (HP:0010295)1.76838480
127Type 2 muscle fiber atrophy (HP:0003554)1.76125925
128Acute encephalopathy (HP:0006846)1.76045615
129Recurrent corneal erosions (HP:0000495)1.75920827
1303-Methylglutaconic aciduria (HP:0003535)1.75816850
131Male pseudohermaphroditism (HP:0000037)1.74487533
132Chronic hepatic failure (HP:0100626)1.73899105
133Dyskinesia (HP:0100660)1.72867832
134Renal cortical cysts (HP:0000803)1.72688771
135Supernumerary spleens (HP:0009799)1.71707177
136Impaired vibration sensation in the lower limbs (HP:0002166)1.71588154
137Absent speech (HP:0001344)1.69225464
138Abnormality of salivation (HP:0100755)1.69061080
139Renovascular hypertension (HP:0100817)1.68373433
140Hepatoblastoma (HP:0002884)1.68264565
141Poor coordination (HP:0002370)1.67896544
142Failure to thrive in infancy (HP:0001531)1.67859744
143Specific learning disability (HP:0001328)1.67800213
144Morphological abnormality of the pyramidal tract (HP:0002062)1.67705677
145Oligodactyly (hands) (HP:0001180)1.67588084
146Labial hypoplasia (HP:0000066)1.67531416
147Fibular hypoplasia (HP:0003038)1.66638570
148Congenital stationary night blindness (HP:0007642)1.66613788
149Symphalangism affecting the phalanges of the hand (HP:0009773)1.66236270
150Exotropia (HP:0000577)1.65710891
151Poor suck (HP:0002033)1.65479271
152Focal seizures (HP:0007359)1.65366980
153Elfin facies (HP:0004428)1.65282117
154Postaxial foot polydactyly (HP:0001830)1.65119336
155Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.64180585
156Left ventricular hypertrophy (HP:0001712)1.64010043
157Osteomalacia (HP:0002749)1.63411278
158Short tibia (HP:0005736)1.62881602

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.79543020
2CASK4.58698492
3ERBB33.27227887
4MAPK132.98986183
5MAP2K72.98759790
6TNIK2.59234037
7SIK32.58172155
8DYRK22.48289209
9LIMK12.39000030
10STK162.16167227
11PINK12.15348999
12SIK22.15284337
13TRIM282.10053328
14NTRK22.04408951
15NTRK31.99624806
16PHKG21.90886039
17PHKG11.90886039
18PNCK1.65878780
19MAP4K21.56168898
20GRK11.55017199
21CDK81.54817329
22CCNB11.52558292
23MAP3K41.51775076
24MINK11.45879188
25BMPR1B1.45421998
26VRK11.44645878
27MAP3K121.42989263
28EIF2AK21.35128698
29CAMKK21.32088392
30MKNK11.30993904
31EPHA41.29853619
32MAP2K41.28896916
33PLK21.27369372
34PKN11.21943068
35FGFR21.21414505
36BCR1.20214203
37SRPK11.14391826
38IRAK21.14002707
39NEK61.09650355
40UHMK11.07132790
41IRAK41.06465652
42SGK4941.05591587
43SGK2231.05591587
44CDK31.02870137
45MARK21.01909962
46OXSR11.01736841
47WNK41.01280184
48CLK10.99220051
49CDC42BPA0.96897555
50MKNK20.94057500
51WNK30.92807275
52PLK30.92643745
53PASK0.88676306
54TXK0.85651824
55STK38L0.84560693
56PRKCG0.81807765
57FRK0.80339883
58DYRK1A0.79601912
59CAMKK10.78007137
60PRKCE0.74558460
61CSNK1G20.72060296
62YES10.71462544
63PRPF4B0.70305873
64RPS6KB10.69267203
65CSNK1G30.68436837
66CSNK1A1L0.67969136
67STK110.67855983
68PIK3CA0.67752537
69CDK50.67715286
70KSR10.66095773
71BRD40.66003162
72CDK190.64476983
73LATS20.63742078
74CAMK10.63198591
75CAMK2B0.62875000
76STK390.62131196
77EPHB20.61855670
78CAMK2A0.59935783
79CDK180.58237829
80TLK10.54654813
81TIE10.54476584
82PRKCZ0.54218548
83MAP3K90.54156635
84ADRBK20.53923825
85EPHA30.53151108
86CAMK1G0.52141431
87NUAK10.52103854
88MUSK0.51678142
89CDK150.51500741
90INSRR0.51290782
91PAK30.51177995
92CDK140.50971818
93CHEK20.50960870
94ROCK10.50608389
95CAMK40.49941661
96CSNK1A10.49691401
97STK240.49371212
98NME10.49070008
99CDK11A0.49037768
100ZAK0.48903342
101CSNK1D0.48539107
102PAK60.48028686
103PRKG10.47497088
104MAPK150.47357753
105IRAK10.47184131
106AKT30.42930552
107PRKCH0.42254113
108ADRBK10.41287900
109CSNK1E0.40449759
110SGK20.39449890
111CAMK2G0.38566056
112CAMK2D0.38367406
113DAPK20.38123015
114DYRK30.37860685
115ATR0.37845479
116ACVR1B0.37436165
117BMPR20.36004051
118RPS6KA20.35410832
119PRKAA10.35191029
120PRKACB0.34937367
121RPS6KA40.34414045
122BCKDK0.34275796
123TYRO30.34153050
124PRKDC0.34008611
125CSNK1G10.33133258
126CDC70.30782446
127PRKCB0.30492368
128CDK10.29841702
129PRKACA0.29417494
130TSSK60.28580893
131SGK10.28241364
132MAP2K60.26802403
133ATM0.26464011
134PLK10.26153416

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.50392613
2Cardiac muscle contraction_Homo sapiens_hsa042602.20609463
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.14496214
4Axon guidance_Homo sapiens_hsa043602.02218938
5Morphine addiction_Homo sapiens_hsa050321.98633991
6Butanoate metabolism_Homo sapiens_hsa006501.97070915
7Serotonergic synapse_Homo sapiens_hsa047261.92766005
8Synaptic vesicle cycle_Homo sapiens_hsa047211.92241440
9GABAergic synapse_Homo sapiens_hsa047271.88814221
10Circadian entrainment_Homo sapiens_hsa047131.88668730
11Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.85638341
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.84195752
13Taste transduction_Homo sapiens_hsa047421.71639749
14Protein export_Homo sapiens_hsa030601.71424049
15Collecting duct acid secretion_Homo sapiens_hsa049661.68050671
16Glutamatergic synapse_Homo sapiens_hsa047241.63207932
17Olfactory transduction_Homo sapiens_hsa047401.63198918
18Phototransduction_Homo sapiens_hsa047441.56065506
19Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.54275148
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.49843356
21Maturity onset diabetes of the young_Homo sapiens_hsa049501.48381126
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.44047596
23SNARE interactions in vesicular transport_Homo sapiens_hsa041301.41832186
24Dopaminergic synapse_Homo sapiens_hsa047281.38755169
25Insulin secretion_Homo sapiens_hsa049111.36566206
26Cocaine addiction_Homo sapiens_hsa050301.33055717
27Regulation of autophagy_Homo sapiens_hsa041401.31009077
28Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.29538372
29Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.27801730
30Amphetamine addiction_Homo sapiens_hsa050311.27107838
31Cholinergic synapse_Homo sapiens_hsa047251.25659236
32Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.23246808
33Fanconi anemia pathway_Homo sapiens_hsa034601.20282727
34Homologous recombination_Homo sapiens_hsa034401.13327031
35Long-term depression_Homo sapiens_hsa047301.13116846
36Type I diabetes mellitus_Homo sapiens_hsa049401.10696044
37Gastric acid secretion_Homo sapiens_hsa049711.10402617
38Autoimmune thyroid disease_Homo sapiens_hsa053201.08422237
39Steroid biosynthesis_Homo sapiens_hsa001001.06695201
40Calcium signaling pathway_Homo sapiens_hsa040201.00899021
41Sphingolipid metabolism_Homo sapiens_hsa006001.00310388
42Selenocompound metabolism_Homo sapiens_hsa004500.98547885
43Linoleic acid metabolism_Homo sapiens_hsa005910.98399742
44Alcoholism_Homo sapiens_hsa050340.97933769
45ErbB signaling pathway_Homo sapiens_hsa040120.97634376
46Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.96932621
47Mismatch repair_Homo sapiens_hsa034300.96566193
48alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.95324468
49Nitrogen metabolism_Homo sapiens_hsa009100.95042672
50RNA polymerase_Homo sapiens_hsa030200.93043540
51Allograft rejection_Homo sapiens_hsa053300.91530392
52Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.91185714
53Asthma_Homo sapiens_hsa053100.89456263
54Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.88216449
55Tryptophan metabolism_Homo sapiens_hsa003800.87359451
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.86707410
57Propanoate metabolism_Homo sapiens_hsa006400.86424271
58Base excision repair_Homo sapiens_hsa034100.86412542
59Long-term potentiation_Homo sapiens_hsa047200.85371420
60Hedgehog signaling pathway_Homo sapiens_hsa043400.84900256
61Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.82752462
62Renin secretion_Homo sapiens_hsa049240.82294471
63Gap junction_Homo sapiens_hsa045400.81045972
64Salivary secretion_Homo sapiens_hsa049700.79455218
65Aldosterone synthesis and secretion_Homo sapiens_hsa049250.79334852
66Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.75664870
67Wnt signaling pathway_Homo sapiens_hsa043100.75156256
68Spliceosome_Homo sapiens_hsa030400.73551996
69DNA replication_Homo sapiens_hsa030300.71659788
70Non-homologous end-joining_Homo sapiens_hsa034500.70650635
71Basal transcription factors_Homo sapiens_hsa030220.70019547
72Vibrio cholerae infection_Homo sapiens_hsa051100.67855601
73Oxidative phosphorylation_Homo sapiens_hsa001900.67602764
74Circadian rhythm_Homo sapiens_hsa047100.67318256
75Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.66463698
76mRNA surveillance pathway_Homo sapiens_hsa030150.66378404
77Ras signaling pathway_Homo sapiens_hsa040140.65960236
78Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.65947035
79beta-Alanine metabolism_Homo sapiens_hsa004100.65776194
80Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.65463095
81Oxytocin signaling pathway_Homo sapiens_hsa049210.65343062
82Melanogenesis_Homo sapiens_hsa049160.64957622
83Type II diabetes mellitus_Homo sapiens_hsa049300.64661282
84Melanoma_Homo sapiens_hsa052180.64058963
85Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.62764743
86N-Glycan biosynthesis_Homo sapiens_hsa005100.62365495
87Cell cycle_Homo sapiens_hsa041100.61796402
88Nucleotide excision repair_Homo sapiens_hsa034200.61586248
89Oocyte meiosis_Homo sapiens_hsa041140.61110383
90Peroxisome_Homo sapiens_hsa041460.61056954
91Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.60737716
92Primary bile acid biosynthesis_Homo sapiens_hsa001200.60683526
93Alzheimers disease_Homo sapiens_hsa050100.59790658
94Intestinal immune network for IgA production_Homo sapiens_hsa046720.59568118
95RNA degradation_Homo sapiens_hsa030180.58689032
96Colorectal cancer_Homo sapiens_hsa052100.58163999
97Phagosome_Homo sapiens_hsa041450.56761897
98Purine metabolism_Homo sapiens_hsa002300.56284602
99Proteasome_Homo sapiens_hsa030500.56201014
100cAMP signaling pathway_Homo sapiens_hsa040240.56098187
101Parkinsons disease_Homo sapiens_hsa050120.55257224
102Ovarian steroidogenesis_Homo sapiens_hsa049130.54972556
103Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.54745235
104Ether lipid metabolism_Homo sapiens_hsa005650.54706058
105Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.54239241
106Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51257089
107Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.50955071
108Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.50263298
109Hippo signaling pathway_Homo sapiens_hsa043900.49905653
110Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.49762701
111Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.47501207
112Glioma_Homo sapiens_hsa052140.47339702
113Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.46723737
114Rheumatoid arthritis_Homo sapiens_hsa053230.46492058
115Basal cell carcinoma_Homo sapiens_hsa052170.45122162
116Huntingtons disease_Homo sapiens_hsa050160.44922406
117Caffeine metabolism_Homo sapiens_hsa002320.44256599
118Hematopoietic cell lineage_Homo sapiens_hsa046400.43912516
119Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.42928453
120Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.42676976
121MAPK signaling pathway_Homo sapiens_hsa040100.42016668
122Pyrimidine metabolism_Homo sapiens_hsa002400.40361779
123Estrogen signaling pathway_Homo sapiens_hsa049150.39927686
124Pancreatic secretion_Homo sapiens_hsa049720.39369779
125Thyroid hormone synthesis_Homo sapiens_hsa049180.38718584
126Chemical carcinogenesis_Homo sapiens_hsa052040.37186281
127ABC transporters_Homo sapiens_hsa020100.35934853
128Dilated cardiomyopathy_Homo sapiens_hsa054140.35125867
129Vitamin B6 metabolism_Homo sapiens_hsa007500.33617305
130Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.32531388
131Metabolic pathways_Homo sapiens_hsa011000.32198866
132Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.31814256
133cGMP-PKG signaling pathway_Homo sapiens_hsa040220.30768832
134Fatty acid elongation_Homo sapiens_hsa000620.30666876
135Steroid hormone biosynthesis_Homo sapiens_hsa001400.30046564

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