DACT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the dapper family, characterized by the presence of PDZ-binding motif at the C-terminus. It interacts with, and positively regulates dishevelled-mediated signaling pathways during development. Depletion of this mRNA from xenopus embryos resulted in loss of notochord and head structures, and mice lacking this gene died shortly after birth from severe posterior malformations. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell migration in hindbrain (GO:0021535)4.35816131
2lateral sprouting from an epithelium (GO:0060601)4.16528856
3axonal fasciculation (GO:0007413)4.13162752
4bone trabecula formation (GO:0060346)4.05101054
5head development (GO:0060322)4.02271127
6positive regulation of SMAD protein import into nucleus (GO:0060391)3.64486434
7planar cell polarity pathway involved in neural tube closure (GO:0090179)3.63134712
8presynaptic membrane organization (GO:0097090)3.61828202
9pyrimidine nucleobase catabolic process (GO:0006208)3.58239480
10positive regulation of cardiac muscle cell differentiation (GO:2000727)3.55293993
11dendritic spine morphogenesis (GO:0060997)3.54330671
12neuron recognition (GO:0008038)3.52069276
13central nervous system projection neuron axonogenesis (GO:0021952)3.45965172
14regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.45395673
15limb bud formation (GO:0060174)3.44255727
16* regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.43459123
17cardiac myofibril assembly (GO:0055003)3.40018667
18negative regulation of catenin import into nucleus (GO:0035414)3.40001078
19atrioventricular valve morphogenesis (GO:0003181)3.39487916
20layer formation in cerebral cortex (GO:0021819)3.31054091
21postsynaptic membrane organization (GO:0001941)3.30229165
22negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.29474492
23regulation of cardiac muscle cell differentiation (GO:2000725)3.27535250
24polarized epithelial cell differentiation (GO:0030859)3.26365486
25camera-type eye morphogenesis (GO:0048593)3.25682781
26negative regulation of axon extension involved in axon guidance (GO:0048843)3.25193363
27cardiac ventricle formation (GO:0003211)3.24529946
28* dendrite morphogenesis (GO:0048813)3.22137055
29cardiac chamber formation (GO:0003207)3.21888949
30gonadal mesoderm development (GO:0007506)3.20835867
31convergent extension (GO:0060026)3.17098769
32chondrocyte development (GO:0002063)3.14540822
33regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901213.13162279
34negative regulation of cytosolic calcium ion concentration (GO:0051481)3.12974225
35outer ear morphogenesis (GO:0042473)3.07954285
36atrial septum morphogenesis (GO:0060413)3.05749758
37regulation of cardioblast differentiation (GO:0051890)3.04459051
38regulation of axon extension involved in axon guidance (GO:0048841)3.04363314
39epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.01124425
40negative regulation of axon guidance (GO:1902668)2.97462569
41positive regulation of cardiac muscle cell proliferation (GO:0060045)2.96305525
42positive regulation of cardiac muscle tissue development (GO:0055025)2.96207048
43establishment of nucleus localization (GO:0040023)2.93585426
44cochlea morphogenesis (GO:0090103)2.92463692
45craniofacial suture morphogenesis (GO:0097094)2.91960555
46regulation of SMAD protein import into nucleus (GO:0060390)2.91720710
47cerebral cortex radially oriented cell migration (GO:0021799)2.90649821
48endodermal cell differentiation (GO:0035987)2.90547194
49dermatan sulfate metabolic process (GO:0030205)2.90541769
50Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.90071781
51neuron cell-cell adhesion (GO:0007158)2.89552106
52regulation of axon guidance (GO:1902667)2.88870453
53cell migration involved in sprouting angiogenesis (GO:0002042)2.88336661
54regulation of transforming growth factor beta2 production (GO:0032909)2.86732053
55hippo signaling (GO:0035329)2.86595112
56cardiac epithelial to mesenchymal transition (GO:0060317)2.86245129
57proximal/distal pattern formation (GO:0009954)2.86178618
58negative regulation of axon extension (GO:0030517)2.85659615
59metanephric mesenchyme development (GO:0072075)2.84122348
60positive regulation of cardiac muscle tissue growth (GO:0055023)2.83740169
61regulation of establishment of planar polarity (GO:0090175)2.82450754
62axon extension (GO:0048675)2.80606728
63* regulation of catenin import into nucleus (GO:0035412)2.79738608
64cartilage morphogenesis (GO:0060536)2.78949375
65cell surface receptor signaling pathway involved in heart development (GO:0061311)2.77786836
66central nervous system neuron axonogenesis (GO:0021955)2.77696507
67apical protein localization (GO:0045176)2.75150091
68collagen fibril organization (GO:0030199)2.73629945
69paraxial mesoderm development (GO:0048339)2.72924053
70glomerular filtration (GO:0003094)2.72771004
71heart valve morphogenesis (GO:0003179)2.71124073
72kidney mesenchyme development (GO:0072074)2.70690200
73peripheral nervous system axon ensheathment (GO:0032292)2.70378968
74myelination in peripheral nervous system (GO:0022011)2.70378968
75* gastrulation with mouth forming second (GO:0001702)2.70272315
76pericardium development (GO:0060039)2.69900633
77semaphorin-plexin signaling pathway (GO:0071526)2.69358649
78positive regulation of heart growth (GO:0060421)2.68455457
79regulation of synapse assembly (GO:0051963)2.68329213
80cell communication by electrical coupling (GO:0010644)2.66651136
81auditory behavior (GO:0031223)2.66200251
82mesenchymal cell differentiation (GO:0048762)2.66033757
83vocalization behavior (GO:0071625)2.65595253
84body morphogenesis (GO:0010171)2.64974680
85hindlimb morphogenesis (GO:0035137)2.64559355
86negative regulation of axonogenesis (GO:0050771)2.64556994
87regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.62863899
88protein heterotrimerization (GO:0070208)2.62800657
89myofibril assembly (GO:0030239)2.62161693
90insulin-like growth factor receptor signaling pathway (GO:0048009)2.61723078
91non-canonical Wnt signaling pathway (GO:0035567)2.59955288
92ventricular septum morphogenesis (GO:0060412)2.59846099
93somite development (GO:0061053)2.59056372
94regulation of cardiac muscle tissue development (GO:0055024)2.59015652
95neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.57887609
96embryonic hindlimb morphogenesis (GO:0035116)2.56991932
97mesenchymal cell development (GO:0014031)2.56772367
98secondary heart field specification (GO:0003139)2.56071894
99heart field specification (GO:0003128)2.56071894
100neurotransmitter-gated ion channel clustering (GO:0072578)2.55246244
101negative regulation of embryonic development (GO:0045992)2.53965732
102chondrocyte proliferation (GO:0035988)2.53753627
103axon ensheathment in central nervous system (GO:0032291)2.53739329
104central nervous system myelination (GO:0022010)2.53739329
105glomerulus development (GO:0032835)2.53295398
106sequestering of extracellular ligand from receptor (GO:0035581)2.52426161
107endocardial cushion morphogenesis (GO:0003203)2.52263490
108positive regulation of epithelial to mesenchymal transition (GO:0010718)2.51936132
109spinal cord development (GO:0021510)2.51912636
110urogenital system development (GO:0001655)2.51473736
111negative regulation of striated muscle cell apoptotic process (GO:0010664)2.51407230
112cranial nerve morphogenesis (GO:0021602)2.51331233
113regulation of NFAT protein import into nucleus (GO:0051532)2.51150027
114neuron projection extension involved in neuron projection guidance (GO:1902284)2.51081718
115axon extension involved in axon guidance (GO:0048846)2.51081718
116membrane assembly (GO:0071709)2.50599737
117neuronal ion channel clustering (GO:0045161)2.50566390
118nucleobase catabolic process (GO:0046113)2.49376520
119establishment of tissue polarity (GO:0007164)2.49134323
120establishment of planar polarity (GO:0001736)2.49134323
121dorsal/ventral axis specification (GO:0009950)2.48531005
122cardiac muscle hypertrophy (GO:0003300)2.47959825
123Notch signaling involved in heart development (GO:0061314)2.47498652
124positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862)2.47288463
125* regulation of non-canonical Wnt signaling pathway (GO:2000050)2.46797005
126mesenchyme morphogenesis (GO:0072132)2.46778935
127regulation of neuron migration (GO:2001222)2.46021754
128endocardial cushion development (GO:0003197)2.44860430
129myelination (GO:0042552)2.44426173
130retinal ganglion cell axon guidance (GO:0031290)2.44024806
131establishment of mitochondrion localization (GO:0051654)2.43846074
132axon ensheathment (GO:0008366)2.42900177
133ensheathment of neurons (GO:0007272)2.42900177
134dermatan sulfate biosynthetic process (GO:0030208)2.42717200
135glial cell migration (GO:0008347)2.42523591
136anatomical structure arrangement (GO:0048532)2.42497362
137embryonic cranial skeleton morphogenesis (GO:0048701)2.42415255
138mesenchyme development (GO:0060485)2.42394534
139negative regulation of cartilage development (GO:0061037)2.41282233
140negative regulation of microtubule polymerization (GO:0031115)2.39663260
141asymmetric protein localization (GO:0008105)2.39226746
142cardiac muscle hypertrophy in response to stress (GO:0014898)2.39049071
143muscle hypertrophy in response to stress (GO:0003299)2.39049071
144cardiac muscle adaptation (GO:0014887)2.39049071
145midgut development (GO:0007494)2.38920997
146cardiac septum morphogenesis (GO:0060411)2.38703816
147epithelial cell differentiation involved in kidney development (GO:0035850)2.38672170
148positive regulation of synapse assembly (GO:0051965)2.38552821
149response to pheromone (GO:0019236)2.37746799
150negative regulation of chondrocyte differentiation (GO:0032331)2.37709168
151presynaptic membrane assembly (GO:0097105)2.37303028
152transmission of nerve impulse (GO:0019226)2.37270969
153neural crest cell development (GO:0014032)2.35851003
154regulation of heart morphogenesis (GO:2000826)2.35590563
155mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.35314266
156cardiac muscle cell development (GO:0055013)2.34996101
157renal filtration (GO:0097205)2.34821470
158generation of neurons (GO:0048699)2.34679278
159regulation of cardiac muscle cell proliferation (GO:0060043)2.34579118
160heart morphogenesis (GO:0003007)2.33831061
161negative regulation of developmental growth (GO:0048640)2.33325744
162notochord development (GO:0030903)2.33286911
163striated muscle hypertrophy (GO:0014897)2.32595746
164cranial suture morphogenesis (GO:0060363)2.32514061
165cell migration involved in heart development (GO:0060973)2.32150342
166* positive regulation of catenin import into nucleus (GO:0035413)2.31316432
167nodal signaling pathway (GO:0038092)2.31245767
168cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.30880318
169collagen catabolic process (GO:0030574)2.30790267
170cardiac cell development (GO:0055006)2.30021237

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.91738375
2EZH2_27304074_Chip-Seq_ESCs_Mouse3.15364814
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.10524270
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.72671528
5EZH2_18974828_ChIP-Seq_MESCs_Mouse2.69292935
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.69292935
7EED_16625203_ChIP-ChIP_MESCs_Mouse2.68574075
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.61543441
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.50526602
10ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.44541747
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.40933859
12SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.39354733
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.35648248
14* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.31435036
15PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.26682781
16CBX2_27304074_Chip-Seq_ESCs_Mouse2.26503945
17* RNF2_27304074_Chip-Seq_ESCs_Mouse2.21406692
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.15187059
19TRIM28_21343339_ChIP-Seq_HEK293_Human2.12466991
20* RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.11569315
21GBX2_23144817_ChIP-Seq_PC3_Human2.10227623
22* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.07061293
23* EZH2_27294783_Chip-Seq_ESCs_Mouse2.05058396
24NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.02673377
25CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.91928528
26RING1B_27294783_Chip-Seq_NPCs_Mouse1.90620473
27* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.89537263
28* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.89013705
29* WT1_19549856_ChIP-ChIP_CCG9911_Human1.87111801
30HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.86712237
31ZNF274_21170338_ChIP-Seq_K562_Hela1.86551777
32RBPJ_22232070_ChIP-Seq_NCS_Mouse1.84990511
33WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.81424543
34BMI1_23680149_ChIP-Seq_NPCS_Mouse1.79485155
35AR_21572438_ChIP-Seq_LNCaP_Human1.71891787
36* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.71325746
37STAT6_21828071_ChIP-Seq_BEAS2B_Human1.70191690
38* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.69595742
39CTBP2_25329375_ChIP-Seq_LNCAP_Human1.67644102
40SALL1_21062744_ChIP-ChIP_HESCs_Human1.65375268
41RING1B_27294783_Chip-Seq_ESCs_Mouse1.64952617
42* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.62039840
43ISL1_27105846_Chip-Seq_CPCs_Mouse1.61373327
44RNF2_27304074_Chip-Seq_NSC_Mouse1.57736161
45POU5F1_16153702_ChIP-ChIP_HESCs_Human1.53904657
46TP53_20018659_ChIP-ChIP_R1E_Mouse1.52245886
47EP300_21415370_ChIP-Seq_HL-1_Mouse1.50946477
48ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.49310640
49POU3F2_20337985_ChIP-ChIP_501MEL_Human1.47534448
50CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.46301365
51ZFP281_18757296_ChIP-ChIP_E14_Mouse1.43655529
52SMAD_19615063_ChIP-ChIP_OVARY_Human1.43408663
53KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.42142530
54KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.42142530
55KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.42142530
56SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.40386375
57DROSHA_22980978_ChIP-Seq_HELA_Human1.39670386
58CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.39157023
59NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.38335336
60NRF2_20460467_ChIP-Seq_MEFs_Mouse1.38335336
61CDX2_19796622_ChIP-Seq_MESCs_Mouse1.34751528
62* TBX3_20139965_ChIP-Seq_MESCs_Mouse1.34304143
63FUS_26573619_Chip-Seq_HEK293_Human1.33621549
64* TBX3_20139965_ChIP-Seq_ESCs_Mouse1.33496725
65PIAS1_25552417_ChIP-Seq_VCAP_Human1.33344893
66SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33205708
67OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32703113
68TP63_19390658_ChIP-ChIP_HaCaT_Human1.30922819
69* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30674991
70CTBP1_25329375_ChIP-Seq_LNCAP_Human1.27083242
71SMAD3_21741376_ChIP-Seq_HESCs_Human1.26803762
72ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.26715582
73BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.25784625
74SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.25391557
75TAF15_26573619_Chip-Seq_HEK293_Human1.24921856
76EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.24859453
77ERG_21242973_ChIP-ChIP_JURKAT_Human1.24616612
78OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.24360031
79ZFP281_27345836_Chip-Seq_ESCs_Mouse1.23739868
80* SMAD3_21741376_ChIP-Seq_EPCs_Human1.22508617
81STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.21522582
82ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.21472850
83SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.19884261
84WT1_25993318_ChIP-Seq_PODOCYTE_Human1.19750684
85POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.19636684
86TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19636684
87SOX9_26525672_Chip-Seq_HEART_Mouse1.19551051
88NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.18110137
89ZNF217_24962896_ChIP-Seq_MCF-7_Human1.17186302
90KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.15942427
91* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.14325318
92DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.14005406
93TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11806299
94* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.11456258
95TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10335342
96SOX2_16153702_ChIP-ChIP_HESCs_Human1.10033247
97SMAD4_21741376_ChIP-Seq_HESCs_Human1.09873221
98CJUN_26792858_Chip-Seq_BT549_Human1.08342399
99AHR_22903824_ChIP-Seq_MCF-7_Human1.08098403
100CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07454957
101ARNT_22903824_ChIP-Seq_MCF-7_Human1.06859913
102SOX2_21211035_ChIP-Seq_LN229_Gbm1.06597821
103REST_21632747_ChIP-Seq_MESCs_Mouse1.06543918
104NFIB_24661679_ChIP-Seq_LUNG_Mouse1.06460123
105* CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.05463231
106TP53_18474530_ChIP-ChIP_U2OS_Human1.04705808
107BRD4_25478319_ChIP-Seq_HGPS_Human1.03593120
108AR_19668381_ChIP-Seq_PC3_Human1.03151119
109YAP1_20516196_ChIP-Seq_MESCs_Mouse1.03126261
110P300_19829295_ChIP-Seq_ESCs_Human1.02802805
111* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.02802615
112* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.02495975
113GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02393866
114* SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.01400596
115KDM2B_26808549_Chip-Seq_K562_Human0.97095119
116SMAD4_21799915_ChIP-Seq_A2780_Human0.96681227
117PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.96646201
118NR3C1_23031785_ChIP-Seq_PC12_Mouse0.95821185
119* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93174855
120* ZFP57_27257070_Chip-Seq_ESCs_Mouse0.93058887
121LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92268992
122TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.92209283
123TP53_16413492_ChIP-PET_HCT116_Human0.91687220
124EWS_26573619_Chip-Seq_HEK293_Human0.91446698

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003122_maternal_imprinting3.70334511
2MP0008438_abnormal_cutaneous_collagen3.26854272
3MP0005503_abnormal_tendon_morphology2.74288316
4MP0003385_abnormal_body_wall2.61958473
5MP0002822_catalepsy2.48975606
6MP0003121_genomic_imprinting2.31518944
7MP0000778_abnormal_nervous_system2.31055523
8MP0004272_abnormal_basement_membrane2.30444081
9MP0010030_abnormal_orbit_morphology2.17846640
10MP0000049_abnormal_middle_ear2.14909927
11* MP0000537_abnormal_urethra_morphology2.11529511
12MP0002938_white_spotting2.07242946
13* MP0009250_abnormal_appendicular_skeleto2.04195345
14MP0003942_abnormal_urinary_system2.04068341
15* MP0003937_abnormal_limbs/digits/tail_de1.94483568
16MP0005623_abnormal_meninges_morphology1.93155425
17MP0005275_abnormal_skin_tensile1.87036384
18MP0002249_abnormal_larynx_morphology1.76394636
19MP0003123_paternal_imprinting1.76357994
20MP0001299_abnormal_eye_distance/1.75333570
21MP0003755_abnormal_palate_morphology1.74514260
22* MP0000534_abnormal_ureter_morphology1.70392220
23* MP0003119_abnormal_digestive_system1.62673491
24MP0003283_abnormal_digestive_organ1.59507566
25MP0003935_abnormal_craniofacial_develop1.57001467
26MP0002282_abnormal_trachea_morphology1.55718234
27MP0003938_abnormal_ear_development1.53680890
28MP0002932_abnormal_joint_morphology1.53645479
29MP0005248_abnormal_Harderian_gland1.52544027
30MP0000569_abnormal_digit_pigmentation1.52168705
31MP0004084_abnormal_cardiac_muscle1.52136484
32MP0002116_abnormal_craniofacial_bone1.51489430
33MP0004270_analgesia1.51107556
34MP0003941_abnormal_skin_development1.44214912
35MP0003890_abnormal_embryonic-extraembry1.44140936
36MP0002184_abnormal_innervation1.43720785
37MP0004134_abnormal_chest_morphology1.42734083
38MP0002102_abnormal_ear_morphology1.42192561
39MP0000767_abnormal_smooth_muscle1.41366014
40MP0000428_abnormal_craniofacial_morphol1.41064023
41MP0002233_abnormal_nose_morphology1.40018056
42* MP0003861_abnormal_nervous_system1.37857148
43MP0009384_cardiac_valve_regurgitation1.36935895
44MP0005187_abnormal_penis_morphology1.35134547
45MP0010368_abnormal_lymphatic_system1.33976135
46MP0001879_abnormal_lymphatic_vessel1.33390988
47MP0003115_abnormal_respiratory_system1.33099110
48MP0000762_abnormal_tongue_morphology1.32809061
49MP0004133_heterotaxia1.31910687
50MP0000566_synostosis1.31373961
51MP0005171_absent_coat_pigmentation1.31363676
52MP0001188_hyperpigmentation1.31245828
53MP0005508_abnormal_skeleton_morphology1.30471375
54MP0003705_abnormal_hypodermis_morpholog1.30468463
55MP0004859_abnormal_synaptic_plasticity1.28892084
56MP0001177_atelectasis1.28823258
57MP0003567_abnormal_fetal_cardiomyocyte1.24311561
58MP0002108_abnormal_muscle_morphology1.23127774
59MP0002735_abnormal_chemical_nociception1.20661462
60MP0000955_abnormal_spinal_cord1.18511327
61MP0001293_anophthalmia1.17653998
62MP0000751_myopathy1.17434816
63* MP0009053_abnormal_anal_canal1.17373672
64* MP0000462_abnormal_digestive_system1.14698967
65MP0002177_abnormal_outer_ear1.14427609
66MP0002896_abnormal_bone_mineralization1.13341994
67MP0000432_abnormal_head_morphology1.13107691
68MP0004145_abnormal_muscle_electrophysio1.08612117
69* MP0002114_abnormal_axial_skeleton1.08579063
70MP0000631_abnormal_neuroendocrine_gland1.07740419
71MP0005257_abnormal_intraocular_pressure1.06728533
72MP0003880_abnormal_central_pattern1.04944032
73MP0002751_abnormal_autonomic_nervous1.03969012
74MP0002152_abnormal_brain_morphology1.03766518
75* MP0003635_abnormal_synaptic_transmissio1.03544571
76MP0004885_abnormal_endolymph1.02741031
77MP0000733_abnormal_muscle_development1.02386356
78* MP0002081_perinatal_lethality1.01994890
79MP0003787_abnormal_imprinting1.01965603
80MP0006276_abnormal_autonomic_nervous1.00616359
81MP0006072_abnormal_retinal_apoptosis1.00383299
82MP0005409_darkened_coat_color1.00061227
83MP0003091_abnormal_cell_migration0.99960013
84MP0003137_abnormal_impulse_conducting0.99591545
85MP0010352_gastrointestinal_tract_polyps0.98823664
86MP0002109_abnormal_limb_morphology0.98127778
87MP0004215_abnormal_myocardial_fiber0.98046064
88MP0006054_spinal_hemorrhage0.97589014
89MP0005423_abnormal_somatic_nervous0.97148129
90MP0000163_abnormal_cartilage_morphology0.97079984
91MP0005620_abnormal_muscle_contractility0.96787206
92MP0003566_abnormal_cell_adhesion0.96125290
93* MP0002111_abnormal_tail_morphology0.95741242
94MP0004233_abnormal_muscle_weight0.94366514
95MP0003315_abnormal_perineum_morphology0.94287949
96MP0002734_abnormal_mechanical_nocicepti0.93699852
97MP0001340_abnormal_eyelid_morphology0.93281126
98* MP0002882_abnormal_neuron_morphology0.92784714
99MP0002697_abnormal_eye_size0.92544864
100MP0009780_abnormal_chondrocyte_physiolo0.92118361
101MP0002295_abnormal_pulmonary_circulatio0.91228627
102* MP0002084_abnormal_developmental_patter0.90367153
103MP0001542_abnormal_bone_strength0.89001724
104MP0001958_emphysema0.87766098
105MP0001529_abnormal_vocalization0.86972918
106MP0003279_aneurysm0.86884964
107MP0002127_abnormal_cardiovascular_syste0.86480750
108MP0002925_abnormal_cardiovascular_devel0.86325126
109* MP0002085_abnormal_embryonic_tissue0.85917352
110MP0001286_abnormal_eye_development0.84928185
111MP0004197_abnormal_fetal_growth/weight/0.84891583
112MP0001486_abnormal_startle_reflex0.84785609
113MP0002752_abnormal_somatic_nervous0.83055708
114MP0002092_abnormal_eye_morphology0.82889402
115MP0002115_abnormal_skeleton_extremities0.82466796
116MP0002234_abnormal_pharynx_morphology0.81889867
117MP0004085_abnormal_heartbeat0.81669487
118MP0002063_abnormal_learning/memory/cond0.80978054
119* MP0009703_decreased_birth_body0.80558488
120MP0002557_abnormal_social/conspecific_i0.80498023
121MP0005388_respiratory_system_phenotype0.78087681
122MP0002133_abnormal_respiratory_system0.78087681
123MP0008775_abnormal_heart_ventricle0.77621730
124MP0004811_abnormal_neuron_physiology0.77308318
125MP0009672_abnormal_birth_weight0.76414063
126MP0005197_abnormal_uvea_morphology0.74398369
127MP0010630_abnormal_cardiac_muscle0.74287407
128MP0002972_abnormal_cardiac_muscle0.72777735
129* MP0002128_abnormal_blood_circulation0.72018032

Predicted human phenotypes

RankGene SetZ-score
1Short 4th metacarpal (HP:0010044)3.97521888
2Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.97521888
3Shallow orbits (HP:0000586)3.58713854
4Abnormality of the 4th metacarpal (HP:0010012)3.29769764
5Vascular tortuosity (HP:0004948)3.27014389
6Arterial tortuosity (HP:0005116)3.26083021
7Aortic aneurysm (HP:0004942)3.22649053
8Protrusio acetabuli (HP:0003179)2.98604835
9Neonatal short-limb short stature (HP:0008921)2.98499481
10Broad metatarsal (HP:0001783)2.97056244
11Atrophic scars (HP:0001075)2.90075798
12Midline defect of the nose (HP:0004122)2.87072843
13Coronal craniosynostosis (HP:0004440)2.86189247
14Buphthalmos (HP:0000557)2.80005998
15Renal duplication (HP:0000075)2.75319955
16Mild short stature (HP:0003502)2.72177284
17Hepatoblastoma (HP:0002884)2.68320902
18Premature rupture of membranes (HP:0001788)2.61861042
19Bladder diverticulum (HP:0000015)2.41229431
20Fragile skin (HP:0001030)2.40992722
21Cutaneous finger syndactyly (HP:0010554)2.38642395
22Ectopia lentis (HP:0001083)2.34801470
23Abdominal situs inversus (HP:0003363)2.34600764
24Abnormality of abdominal situs (HP:0011620)2.34600764
25Morphological abnormality of the middle ear (HP:0008609)2.32981613
26Dilatation of the ascending aorta (HP:0005111)2.31847255
27Limited hip movement (HP:0008800)2.29416423
28Follicular hyperkeratosis (HP:0007502)2.29277266
29Hip contracture (HP:0003273)2.28266434
30Anteriorly placed anus (HP:0001545)2.27403980
31Abnormality of the parietal bone (HP:0002696)2.26237048
32Abnormality of dentin (HP:0010299)2.23860186
33Turricephaly (HP:0000262)2.23316219
34Spondylolisthesis (HP:0003302)2.23182642
35Narrow nasal bridge (HP:0000446)2.22112688
36Trigonocephaly (HP:0000243)2.18312702
37Peritonitis (HP:0002586)2.17795688
38Abnormality of the labia minora (HP:0012880)2.17587832
39Type 1 muscle fiber predominance (HP:0003803)2.16467345
40Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.15839731
41Alacrima (HP:0000522)2.15025514
42Macroorchidism (HP:0000053)2.14336503
43Broad ribs (HP:0000885)2.12441502
44Blue sclerae (HP:0000592)2.09392417
45Wide anterior fontanel (HP:0000260)2.07104264
46Joint laxity (HP:0001388)2.06579136
47Asymmetry of the thorax (HP:0001555)2.03549068
48Lymphangioma (HP:0100764)2.01422875
49Bell-shaped thorax (HP:0001591)2.00676498
50Calcaneovalgus deformity (HP:0001848)2.00426009
51Cutaneous syndactyly (HP:0012725)1.99986396
52Insidious onset (HP:0003587)1.98723069
53Termporal pattern (HP:0011008)1.98723069
54Infantile muscular hypotonia (HP:0008947)1.97036935
55Microglossia (HP:0000171)1.94999025
56Vertebral arch anomaly (HP:0008438)1.94856307
57Myelomeningocele (HP:0002475)1.93046008
58Abnormality of the corticospinal tract (HP:0002492)1.92903473
59Aplasia/Hypoplasia of the hallux (HP:0008362)1.92398843
60Ankle contracture (HP:0006466)1.92295332
61Pulmonic stenosis (HP:0001642)1.92147298
62Sacral dimple (HP:0000960)1.90838776
63Preaxial foot polydactyly (HP:0001841)1.90153445
64Hypoplasia of the iris (HP:0007676)1.89855638
65Deviation of the hallux (HP:0010051)1.89573701
66Soft skin (HP:0000977)1.89558777
67Deformed tarsal bones (HP:0008119)1.88831943
68Wrist flexion contracture (HP:0001239)1.87331164
69Congenital glaucoma (HP:0001087)1.86864119
70Vitreoretinal degeneration (HP:0000655)1.86387689
71Hypoventilation (HP:0002791)1.85574566
72Abnormality of the phalanges of the 2nd finger (HP:0009541)1.85234536
73Aqueductal stenosis (HP:0002410)1.84999679
74Abnormality of the middle phalanges of the toes (HP:0010183)1.84919823
75Mitral regurgitation (HP:0001653)1.83061178
76Drooling (HP:0002307)1.82901423
77Hallux valgus (HP:0001822)1.82712157
78Broad toe (HP:0001837)1.82200288
79Flat cornea (HP:0007720)1.81904775
80Chin dimple (HP:0010751)1.81088730
81Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.79635860
82Hyperextensible skin (HP:0000974)1.79027742
83Overriding aorta (HP:0002623)1.79001726
84Hypoplastic ischia (HP:0003175)1.78816646
85Abnormality of the diencephalon (HP:0010662)1.77929886
86Mitral valve prolapse (HP:0001634)1.77754751
87Neoplasm of the heart (HP:0100544)1.76218174
88Partial agenesis of the corpus callosum (HP:0001338)1.75390969
89Overgrowth (HP:0001548)1.74782248
90Venous insufficiency (HP:0005293)1.74588107
91Short hallux (HP:0010109)1.72868378
92Broad thumb (HP:0011304)1.71583575
93Hypoplasia of the maxilla (HP:0000327)1.71582834
94Abnormal delivery (HP:0001787)1.70959708
95Aortic regurgitation (HP:0001659)1.70933568
96Broad finger (HP:0001500)1.70156463
97Thin ribs (HP:0000883)1.69915294
98Mesomelia (HP:0003027)1.69666893
99Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.69375160
100Degeneration of the lateral corticospinal tracts (HP:0002314)1.69375160
101Retinal dysplasia (HP:0007973)1.68742560
102Pulmonary artery stenosis (HP:0004415)1.68720219
103Broad long bones (HP:0005622)1.68640056
104Protruding ear (HP:0000411)1.68414752
105Renovascular hypertension (HP:0100817)1.68299326
106Abnormality of the calf musculature (HP:0001430)1.67878358
107Spinal rigidity (HP:0003306)1.67270487
108Wormian bones (HP:0002645)1.66286261
109Severe Myopia (HP:0011003)1.63965270
110Hammertoe (HP:0001765)1.63889360
111Anophthalmia (HP:0000528)1.63874752
112Excessive salivation (HP:0003781)1.63817266
113Short 1st metacarpal (HP:0010034)1.63654584
114Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.63654584
115Decreased lacrimation (HP:0000633)1.63652521
116Aortic valve stenosis (HP:0001650)1.63596142
117Persistence of primary teeth (HP:0006335)1.63258627
118Short phalanx of the thumb (HP:0009660)1.62654433
119Labial hypoplasia (HP:0000066)1.62396772
120Genu recurvatum (HP:0002816)1.62143812
121Bowel diverticulosis (HP:0005222)1.61724653
122Exostoses (HP:0100777)1.61720572
123Knee flexion contracture (HP:0006380)1.61620167
124Aortic dissection (HP:0002647)1.61090039
125Broad phalanx (HP:0006009)1.60917773
126Biconcave vertebral bodies (HP:0004586)1.60817047
127Relative macrocephaly (HP:0004482)1.60734996
128Round face (HP:0000311)1.59870310
129Slender build (HP:0001533)1.59711530
130Disproportionate tall stature (HP:0001519)1.59381760
131Abnormality of the pubic bones (HP:0003172)1.59115762
132Bifid tongue (HP:0010297)1.59058772
133Osteoarthritis (HP:0002758)1.58966739
134Breech presentation (HP:0001623)1.58658114
135Ankyloglossia (HP:0010296)1.58074190
136Intellectual disability, moderate (HP:0002342)1.56996204
137Supernumerary ribs (HP:0005815)1.56954502
138Choanal stenosis (HP:0000452)1.56577452
139Inguinal hernia (HP:0000023)1.56508817
140Abnormality of the ischium (HP:0003174)1.56235864
141Broad phalanges of the hand (HP:0009768)1.56157144
142Keratoconus (HP:0000563)1.56067626
143Increased corneal curvature (HP:0100692)1.56067626
144Round ear (HP:0100830)1.55990316
145Cerebral aneurysm (HP:0004944)1.55809477
146Abnormality of the phalanges of the hallux (HP:0010057)1.55447383
147Aplasia/Hypoplasia of the brainstem (HP:0007362)1.55278850
148Hypoplasia of the brainstem (HP:0002365)1.55278850
149Abnormality of the aortic arch (HP:0012303)1.55023241
150Absent frontal sinuses (HP:0002688)1.54950839
151Abnormality of the nasolacrimal system (HP:0000614)1.54671515
152Bronchomalacia (HP:0002780)1.54612898
153Epileptic encephalopathy (HP:0200134)1.54029368
154Delayed gross motor development (HP:0002194)1.53407059
155Shawl scrotum (HP:0000049)1.52223956

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.61288231
2DDR22.90252854
3STK38L2.75092647
4EPHB22.70780712
5STK392.54213751
6ICK2.37770845
7MAPK132.27227744
8DYRK22.19170977
9FGFR22.09990119
10BCR2.07958810
11UHMK12.04555121
12LATS22.02396131
13CSNK1A1L1.97050952
14PDGFRA1.85756036
15PKN21.83773340
16TYRO31.78492471
17PHKG21.70800302
18PHKG11.70800302
19NTRK21.69804442
20PAK61.69663592
21EPHA31.67503495
22ERBB31.64185762
23CSNK1G31.56331671
24PNCK1.54541927
25KSR11.52846487
26CCNB11.51949915
27LATS11.51285517
28CSNK1G21.39633703
29CSNK1G11.37815101
30PAK31.33259920
31WNK41.32697556
32LIMK11.31874744
33MKNK11.31305275
34STK31.29345256
35MAP3K41.28606100
36WNK11.28006386
37WEE11.27838776
38PKN11.27828850
39STK241.25289345
40CAMK1G1.19262338
41MYLK1.15987234
42OBSCN1.14517305
43SIK21.12597407
44DMPK1.11407361
45FLT31.11091015
46OXSR11.08276315
47MARK21.04880468
48NTRK11.02684848
49MAPK71.01399484
50MKNK20.96465844
51BRSK20.95664804
52ERBB20.95308776
53FGFR10.94568214
54MET0.92963327
55NTRK30.92173756
56MINK10.91911004
57BRD40.90948579
58NLK0.87748781
59DYRK30.87682057
60PDGFRB0.87305181
61MAP2K70.86754186
62PTK20.84173028
63PAK20.83747644
64CDK140.83742904
65TAF10.83580972
66RIPK10.82960592
67CDK120.82591656
68MUSK0.81781164
69MAPK150.78559564
70CDK50.77541011
71BMPR1B0.77492272
72MTOR0.75003158
73ROCK10.73826919
74CDC42BPA0.73445859
75ROCK20.72177633
76CDK150.69324560
77PLK40.68537276
78WNK30.67225677
79CDK180.66858901
80PTK60.66308144
81PRPF4B0.65969384
82ILK0.65721325
83DYRK1B0.63585350
84STK110.63072863
85STK380.62805566
86ERBB40.62569867
87CAMK2B0.61772484
88DYRK1A0.61239144
89NUAK10.59894767
90CDK11A0.59500739
91RET0.59442161
92TTN0.58926074
93ADRBK10.58862067
94MELK0.58571186
95PRKD30.58556821
96TNIK0.58417747
97PLK20.57592771
98SIK10.57506918
99MAP3K90.57377270
100GSK3A0.55467646
101MAP2K40.54087716
102SGK20.53733941
103CSNK1D0.53472609
104CSNK1E0.53459216
105MAPK90.52588769
106CASK0.51536025
107PRKCE0.51093263
108EPHA40.51070591
109MAP3K100.49540519
110AKT30.49106376
111CAMK1D0.49100738
112ALK0.48477183
113FGR0.48061661
114MAP3K20.47524649
115MAPK120.46991289
116CAMK10.46553613
117SGK4940.46425684
118SGK2230.46425684
119CAMK2A0.45426938
120FYN0.45180148
121NEK90.44661507
122MAP3K60.44081858
123YES10.43006083
124PRKCH0.42697216
125NEK20.42295197
126TRIB30.41825660
127CDK30.41084691
128INSRR0.40973627
129INSR0.40945113
130CAMK2D0.40621687
131CDK10.40607753
132CDK190.40566682
133PRKCG0.40442163
134TSSK60.39901530
135MAPK100.39323994
136PRKD20.39199612
137RPS6KA40.34294558
138PRKG10.34293691
139MAP3K70.33743802

Predicted pathways (KEGG)

RankGene SetZ-score
1Axon guidance_Homo sapiens_hsa043603.16754146
2Hedgehog signaling pathway_Homo sapiens_hsa043402.97147031
3Basal cell carcinoma_Homo sapiens_hsa052172.93967314
4Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.26932145
5ECM-receptor interaction_Homo sapiens_hsa045122.15624660
6Hippo signaling pathway_Homo sapiens_hsa043902.13467556
7Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.01060344
8Wnt signaling pathway_Homo sapiens_hsa043101.95056574
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.78662284
10TGF-beta signaling pathway_Homo sapiens_hsa043501.74688843
11Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.64913462
12Focal adhesion_Homo sapiens_hsa045101.61424181
13Melanogenesis_Homo sapiens_hsa049161.60651298
14Gap junction_Homo sapiens_hsa045401.59999949
15Dilated cardiomyopathy_Homo sapiens_hsa054141.56595829
16AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.53404750
17Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.51833014
18Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.49668753
19Renal cell carcinoma_Homo sapiens_hsa052111.47625456
20Glutamatergic synapse_Homo sapiens_hsa047241.45585423
21Long-term depression_Homo sapiens_hsa047301.45001739
22Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.40561473
23Circadian entrainment_Homo sapiens_hsa047131.39555879
24Colorectal cancer_Homo sapiens_hsa052101.38651275
25Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.34991831
26Protein digestion and absorption_Homo sapiens_hsa049741.32816983
27Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.32795205
28MicroRNAs in cancer_Homo sapiens_hsa052061.31722385
29Dopaminergic synapse_Homo sapiens_hsa047281.30836642
30Cocaine addiction_Homo sapiens_hsa050301.30832307
31Tight junction_Homo sapiens_hsa045301.27589059
32Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.27140857
33Cholinergic synapse_Homo sapiens_hsa047251.25585240
34Nicotine addiction_Homo sapiens_hsa050331.24646005
35Proteoglycans in cancer_Homo sapiens_hsa052051.24384037
36Small cell lung cancer_Homo sapiens_hsa052221.23470159
37Adherens junction_Homo sapiens_hsa045201.22115040
38Endometrial cancer_Homo sapiens_hsa052131.19192481
39Renin secretion_Homo sapiens_hsa049241.18308675
40GABAergic synapse_Homo sapiens_hsa047271.14740601
41Estrogen signaling pathway_Homo sapiens_hsa049151.13155761
42mRNA surveillance pathway_Homo sapiens_hsa030151.12697714
43Long-term potentiation_Homo sapiens_hsa047201.11718670
44ErbB signaling pathway_Homo sapiens_hsa040121.10993681
45Serotonergic synapse_Homo sapiens_hsa047261.10990046
46Amphetamine addiction_Homo sapiens_hsa050311.09009002
47Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.06617040
48Cardiac muscle contraction_Homo sapiens_hsa042601.06483269
49PI3K-Akt signaling pathway_Homo sapiens_hsa041511.04899100
50Oocyte meiosis_Homo sapiens_hsa041141.04382801
51Insulin secretion_Homo sapiens_hsa049111.04022511
52Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.99488605
53cGMP-PKG signaling pathway_Homo sapiens_hsa040220.98414678
54Oxytocin signaling pathway_Homo sapiens_hsa049210.98268291
55Melanoma_Homo sapiens_hsa052180.97223523
56Aldosterone synthesis and secretion_Homo sapiens_hsa049250.96009811
57Pathways in cancer_Homo sapiens_hsa052000.95572061
58Steroid biosynthesis_Homo sapiens_hsa001000.93933088
59GnRH signaling pathway_Homo sapiens_hsa049120.91737982
60Regulation of actin cytoskeleton_Homo sapiens_hsa048100.91673030
61Viral myocarditis_Homo sapiens_hsa054160.90973471
62Glioma_Homo sapiens_hsa052140.90316600
63Morphine addiction_Homo sapiens_hsa050320.89075247
64Prostate cancer_Homo sapiens_hsa052150.89045417
65Type II diabetes mellitus_Homo sapiens_hsa049300.88914464
66Vascular smooth muscle contraction_Homo sapiens_hsa042700.88510097
67Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.87991677
68Dorso-ventral axis formation_Homo sapiens_hsa043200.87724665
69MAPK signaling pathway_Homo sapiens_hsa040100.87383574
70Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.83926338
71Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.83145888
72mTOR signaling pathway_Homo sapiens_hsa041500.82872784
73Alcoholism_Homo sapiens_hsa050340.82815048
74Ras signaling pathway_Homo sapiens_hsa040140.82610117
75Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.82571100
76Notch signaling pathway_Homo sapiens_hsa043300.81832298
77Rap1 signaling pathway_Homo sapiens_hsa040150.81737791
78cAMP signaling pathway_Homo sapiens_hsa040240.79836732
79Phospholipase D signaling pathway_Homo sapiens_hsa040720.76925911
80Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.76315676
81p53 signaling pathway_Homo sapiens_hsa041150.74768729
82Lysine degradation_Homo sapiens_hsa003100.73648524
83Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.73453613
84Circadian rhythm_Homo sapiens_hsa047100.72877853
85Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.72177696
86Prion diseases_Homo sapiens_hsa050200.71866030
87FoxO signaling pathway_Homo sapiens_hsa040680.70249715
88Amoebiasis_Homo sapiens_hsa051460.69770409
89AMPK signaling pathway_Homo sapiens_hsa041520.69262374
90Taste transduction_Homo sapiens_hsa047420.67918658
91Selenocompound metabolism_Homo sapiens_hsa004500.61588582
92Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.61505457
93Salivary secretion_Homo sapiens_hsa049700.58985192
94Calcium signaling pathway_Homo sapiens_hsa040200.58504622
95Choline metabolism in cancer_Homo sapiens_hsa052310.58432162
96Neurotrophin signaling pathway_Homo sapiens_hsa047220.57651386
97Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56765414
98Endocytosis_Homo sapiens_hsa041440.56739737
99Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55414025
100Olfactory transduction_Homo sapiens_hsa047400.54298525
101Ovarian steroidogenesis_Homo sapiens_hsa049130.53990917
102Longevity regulating pathway - mammal_Homo sapiens_hsa042110.53704196
103Chronic myeloid leukemia_Homo sapiens_hsa052200.53061191
104Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.50880399
105Gastric acid secretion_Homo sapiens_hsa049710.50132986
106Thyroid hormone synthesis_Homo sapiens_hsa049180.49059058
107Central carbon metabolism in cancer_Homo sapiens_hsa052300.48422540
108Vibrio cholerae infection_Homo sapiens_hsa051100.48235892
109Platelet activation_Homo sapiens_hsa046110.47025254
110Pancreatic cancer_Homo sapiens_hsa052120.45833258
111Prolactin signaling pathway_Homo sapiens_hsa049170.41317975
112Cell cycle_Homo sapiens_hsa041100.37162213

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