DACT2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1estrogen biosynthetic process (GO:0006703)9.55860834
2nodal signaling pathway (GO:0038092)5.99234281
3response to follicle-stimulating hormone (GO:0032354)5.86285274
4cell migration involved in gastrulation (GO:0042074)5.59776365
5positive regulation of SMAD protein import into nucleus (GO:0060391)5.18732301
6glucocorticoid biosynthetic process (GO:0006704)5.10643193
7synaptic vesicle maturation (GO:0016188)4.93882014
8negative regulation of androgen receptor signaling pathway (GO:0060766)4.90367352
9regulation of mesoderm development (GO:2000380)4.89562042
10digestive tract morphogenesis (GO:0048546)4.49970004
11regulation of posttranscriptional gene silencing (GO:0060147)4.44445762
12regulation of gene silencing by miRNA (GO:0060964)4.44445762
13regulation of gene silencing by RNA (GO:0060966)4.44445762
14paraxial mesoderm development (GO:0048339)4.32976138
15regulation of short-term neuronal synaptic plasticity (GO:0048172)4.31345625
16notochord development (GO:0030903)4.30175192
17primitive streak formation (GO:0090009)4.28209856
18SMAD protein signal transduction (GO:0060395)4.19197972
19locomotory exploration behavior (GO:0035641)4.17930301
20regulation of SMAD protein import into nucleus (GO:0060390)4.16071763
21estrogen metabolic process (GO:0008210)4.15935040
22regulation of Wnt signaling pathway involved in heart development (GO:0003307)4.14025544
23female pregnancy (GO:0007565)4.09474486
24synaptic vesicle docking involved in exocytosis (GO:0016081)4.05404618
25regulation of cardioblast differentiation (GO:0051890)4.04608159
26regulation of gonadotropin secretion (GO:0032276)4.01066796
27glutamate secretion (GO:0014047)4.00028505
28positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.97931636
29proline transport (GO:0015824)3.96219026
30vitamin transmembrane transport (GO:0035461)3.83188717
31embryonic process involved in female pregnancy (GO:0060136)3.83154385
32positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.74431892
33regulation of gastrulation (GO:0010470)3.71827653
34androgen biosynthetic process (GO:0006702)3.71065649
35somite rostral/caudal axis specification (GO:0032525)3.61556188
36cytoskeletal anchoring at plasma membrane (GO:0007016)3.59849923
37activin receptor signaling pathway (GO:0032924)3.58377258
38maternal placenta development (GO:0001893)3.57892075
39* regulation of activin receptor signaling pathway (GO:0032925)3.56576527
40response to gonadotropin (GO:0034698)3.53578743
41layer formation in cerebral cortex (GO:0021819)3.50254098
42polarized epithelial cell differentiation (GO:0030859)3.49712569
43synaptic vesicle exocytosis (GO:0016079)3.49551078
44erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.48274698
45L-phenylalanine metabolic process (GO:0006558)3.48274698
46alanine transport (GO:0032328)3.46686573
47mesenchymal cell proliferation (GO:0010463)3.46533463
48prostate gland growth (GO:0060736)3.45412052
49cardiac right ventricle morphogenesis (GO:0003215)3.44644985
50regulation of stem cell maintenance (GO:2000036)3.44394100
51sulfur amino acid catabolic process (GO:0000098)3.43369836
52apoptotic process involved in morphogenesis (GO:0060561)3.39689969
53erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.34660958
54L-phenylalanine catabolic process (GO:0006559)3.34660958
55branching involved in labyrinthine layer morphogenesis (GO:0060670)3.31820406
56glycine transport (GO:0015816)3.30174000
57neurotransmitter secretion (GO:0007269)3.29246804
58vocalization behavior (GO:0071625)3.27997336
59regulation of cholesterol homeostasis (GO:2000188)3.27687768
60L-ascorbic acid metabolic process (GO:0019852)3.26406452
61dorsal/ventral axis specification (GO:0009950)3.25262501
62anterior/posterior axis specification (GO:0009948)3.22632792
63embryonic axis specification (GO:0000578)3.21734118
64positive regulation of growth hormone secretion (GO:0060124)3.21578981
65* negative regulation of activin receptor signaling pathway (GO:0032926)3.21393042
66embryonic foregut morphogenesis (GO:0048617)3.20003582
67regulation of synaptic vesicle exocytosis (GO:2000300)3.19915680
68regulation of neuronal synaptic plasticity (GO:0048168)3.18337824
69neuromuscular process controlling balance (GO:0050885)3.16854328
70cranial suture morphogenesis (GO:0060363)3.14507919
71androgen metabolic process (GO:0008209)3.13184417
72dicarboxylic acid biosynthetic process (GO:0043650)3.13013628
73apical protein localization (GO:0045176)3.12957775
74signal transduction involved in regulation of gene expression (GO:0023019)3.09987842
75glutamate metabolic process (GO:0006536)3.07944430
76establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)3.06324358
77glucocorticoid metabolic process (GO:0008211)3.05836310
78regulation of timing of cell differentiation (GO:0048505)3.05428229
79lung epithelium development (GO:0060428)3.05205669
80regulation of long-term neuronal synaptic plasticity (GO:0048169)3.05042951
81regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.04910545
82regulation of glutamate receptor signaling pathway (GO:1900449)3.04831528
83peptidyl-glutamic acid carboxylation (GO:0017187)3.04081224
84protein carboxylation (GO:0018214)3.04081224
85embryonic retina morphogenesis in camera-type eye (GO:0060059)3.02346899
86sequestering of extracellular ligand from receptor (GO:0035581)2.98647982
87cellular modified amino acid catabolic process (GO:0042219)2.98214148
88lung morphogenesis (GO:0060425)2.98039479
89regulation of cell fate specification (GO:0042659)2.94078069
90embryonic pattern specification (GO:0009880)2.93635650
91female genitalia development (GO:0030540)2.93394886
92positive regulation of gastrulation (GO:2000543)2.92095669
93sodium ion export (GO:0071436)2.91893177
94cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.89094802
95triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.88214430
96planar cell polarity pathway involved in neural tube closure (GO:0090179)2.87974452
97multi-multicellular organism process (GO:0044706)2.87768559
98convergent extension (GO:0060026)2.87475244
99semaphorin-plexin signaling pathway (GO:0071526)2.87292801
100branching involved in salivary gland morphogenesis (GO:0060445)2.86578623
101dendritic spine morphogenesis (GO:0060997)2.84248140
102bone morphogenesis (GO:0060349)2.83642938
103lung-associated mesenchyme development (GO:0060484)2.83567879
104lymphangiogenesis (GO:0001946)2.80741865
105kidney morphogenesis (GO:0060993)2.79858133
106regulation of transforming growth factor beta2 production (GO:0032909)2.79633164
107regulation of hippo signaling (GO:0035330)2.77952982
108regulation of synaptic vesicle transport (GO:1902803)2.73718613
109neurotransmitter-gated ion channel clustering (GO:0072578)2.73196249
110regulation of development, heterochronic (GO:0040034)2.72471396
111urea metabolic process (GO:0019627)2.72313440
112urea cycle (GO:0000050)2.72313440
113lysine catabolic process (GO:0006554)2.71524644
114lysine metabolic process (GO:0006553)2.71524644
115hormone biosynthetic process (GO:0042446)2.71225292
116negative regulation of hormone biosynthetic process (GO:0032353)2.71016722
117negative regulation of hormone metabolic process (GO:0032351)2.71016722
118establishment of apical/basal cell polarity (GO:0035089)2.70791958
119cysteine metabolic process (GO:0006534)2.69805644
120activation of protein kinase A activity (GO:0034199)2.69492302
121neuromuscular process controlling posture (GO:0050884)2.68495996
122gamma-aminobutyric acid transport (GO:0015812)2.67624359
123aromatic amino acid family catabolic process (GO:0009074)2.66575342
124post-embryonic morphogenesis (GO:0009886)2.65751243
125negative regulation of cell fate specification (GO:0009996)2.65738061
126regulation of tight junction assembly (GO:2000810)2.64953981
127response to BMP (GO:0071772)2.64821349
128cellular response to BMP stimulus (GO:0071773)2.64821349
129cell communication involved in cardiac conduction (GO:0086065)2.64792061
130exploration behavior (GO:0035640)2.64714781
131bundle of His cell to Purkinje myocyte communication (GO:0086069)2.64640779
132G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.64072029
133cell-cell junction maintenance (GO:0045217)2.63998994
134glutamine family amino acid biosynthetic process (GO:0009084)2.63414730
135establishment or maintenance of bipolar cell polarity (GO:0061245)2.61673339
136establishment or maintenance of apical/basal cell polarity (GO:0035088)2.61673339
137negative regulation of intracellular steroid hormone receptor signaling pathway (GO:0033144)2.60333837
138atrioventricular valve morphogenesis (GO:0003181)2.60183334
139hippo signaling (GO:0035329)2.60050379
140female gonad development (GO:0008585)2.59623252
141positive regulation of synapse maturation (GO:0090129)2.59599030
142hemidesmosome assembly (GO:0031581)2.59106069
143multi-organism reproductive process (GO:0044703)2.58812163
144cellular potassium ion homeostasis (GO:0030007)2.57403024
145apoptotic process involved in development (GO:1902742)2.57136930
146L-serine metabolic process (GO:0006563)2.56817992
147regulation of growth hormone secretion (GO:0060123)2.56020726
148response to dietary excess (GO:0002021)2.55937316
149cell migration in hindbrain (GO:0021535)2.55401130
150cerebellar Purkinje cell layer development (GO:0021680)2.55372153
151negative regulation of sodium ion transport (GO:0010766)2.54886544
152negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.54362629
153positive regulation of cardiac muscle cell proliferation (GO:0060045)2.53720207
154short-term memory (GO:0007614)2.53567140
155regulation of clathrin-mediated endocytosis (GO:2000369)2.53173660
156kynurenine metabolic process (GO:0070189)2.53125958
157regulation of dendritic spine morphogenesis (GO:0061001)2.52698703
158bile acid biosynthetic process (GO:0006699)2.52527978
159alpha-linolenic acid metabolic process (GO:0036109)2.51407559
160intestinal cholesterol absorption (GO:0030299)2.50699103
161anterior/posterior axis specification, embryo (GO:0008595)2.49310102
162negative regulation of sterol transport (GO:0032372)2.47920035
163negative regulation of cholesterol transport (GO:0032375)2.47920035
164signal complex assembly (GO:0007172)2.47583823
165cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.44991473
166phosphate ion transmembrane transport (GO:0035435)2.44815518
167glyoxylate metabolic process (GO:0046487)2.43632621
168phosphate ion transport (GO:0006817)2.43031378
169serine family amino acid catabolic process (GO:0009071)2.42125302
170high-density lipoprotein particle remodeling (GO:0034375)2.41626231
171regulation of synapse structural plasticity (GO:0051823)2.41292755
172cell junction maintenance (GO:0034331)2.40828326
173nitrogen cycle metabolic process (GO:0071941)2.39650123
174proline biosynthetic process (GO:0006561)2.38312165
175homocysteine metabolic process (GO:0050667)2.37943169
176dicarboxylic acid catabolic process (GO:0043649)2.37508891
177regulation of synaptic plasticity (GO:0048167)2.37112540
178aspartate family amino acid catabolic process (GO:0009068)2.36908884
179neurotransmitter transport (GO:0006836)2.35743327
180positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.35429289
181virion attachment to host cell (GO:0019062)2.34158689
182adhesion of symbiont to host cell (GO:0044650)2.34158689
183macroautophagy (GO:0016236)2.31959929
184L-alpha-amino acid transmembrane transport (GO:1902475)2.29611266
185establishment of monopolar cell polarity (GO:0061162)2.29489474
186establishment or maintenance of monopolar cell polarity (GO:0061339)2.29489474
187dendritic spine organization (GO:0097061)2.28925278
188bile acid metabolic process (GO:0008206)2.28309705
189protein localization to synapse (GO:0035418)2.28278293
190positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.26651161
191regulation of neurotransmitter levels (GO:0001505)2.26402290

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.48960957
2* SMAD3_21741376_ChIP-Seq_HESCs_Human2.76543867
3* RXR_22158963_ChIP-Seq_LIVER_Mouse2.72145986
4SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.64815848
5EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.61962904
6ERG_21242973_ChIP-ChIP_JURKAT_Human2.41352941
7ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.39784304
8RARB_27405468_Chip-Seq_BRAIN_Mouse2.38997276
9ZFP281_18757296_ChIP-ChIP_E14_Mouse2.36961074
10ZNF263_19887448_ChIP-Seq_K562_Human2.33757788
11* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.32495566
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.28082593
13* LXR_22158963_ChIP-Seq_LIVER_Mouse2.20027389
14* SMAD4_21741376_ChIP-Seq_HESCs_Human2.15475522
15* NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.07206767
16MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.99388962
17ESR2_21235772_ChIP-Seq_MCF-7_Human1.91864411
18FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.90857120
19* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.88784946
20TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.86283861
21TP63_17297297_ChIP-ChIP_HaCaT_Human1.80487058
22ESR1_15608294_ChIP-ChIP_MCF-7_Human1.79710572
23DROSHA_22980978_ChIP-Seq_HELA_Human1.78585528
24KDM2B_26808549_Chip-Seq_K562_Human1.74977700
25EZH2_22144423_ChIP-Seq_EOC_Human1.74906282
26* LXR_22292898_ChIP-Seq_THP-1_Human1.74748486
27NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.73434485
28DNAJC2_21179169_ChIP-ChIP_NT2_Human1.72786975
29KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.68875674
30KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.68875674
31KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.68875674
32ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.68019110
33NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.59943239
34REST_21632747_ChIP-Seq_MESCs_Mouse1.59007323
35E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.58781312
36EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.55450861
37WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.54833277
38REST_18959480_ChIP-ChIP_MESCs_Mouse1.51009387
39* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.49883405
40POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.48590377
41SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.48586800
42SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.47855353
43ISL1_27105846_Chip-Seq_CPCs_Mouse1.47687950
44RACK7_27058665_Chip-Seq_MCF-7_Human1.47641751
45PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.46667551
46SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.46422115
47RNF2_18974828_ChIP-Seq_MESCs_Mouse1.45716098
48EZH2_18974828_ChIP-Seq_MESCs_Mouse1.45716098
49TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.45295102
50* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.43699611
51RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.43637580
52RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.42953583
53NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.41664918
54KDM2B_26808549_Chip-Seq_SUP-B15_Human1.41638474
55JARID2_20075857_ChIP-Seq_MESCs_Mouse1.39758012
56SALL1_21062744_ChIP-ChIP_HESCs_Human1.39370296
57* CREB1_26743006_Chip-Seq_LNCaP_Human1.39163968
58MTF2_20144788_ChIP-Seq_MESCs_Mouse1.34523290
59SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.34302812
60EOMES_21245162_ChIP-Seq_HESCs_Human1.34283155
61SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.33669579
62NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.32954613
63* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.32050941
64ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.32026959
65PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.30640645
66POU5F1_16518401_ChIP-PET_MESCs_Mouse1.30211429
67STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.29332137
68CTCF_27219007_Chip-Seq_Bcells_Human1.28342363
69SUZ12_27294783_Chip-Seq_ESCs_Mouse1.26552756
70* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.26416952
71RNF2_27304074_Chip-Seq_ESCs_Mouse1.26132327
72EED_16625203_ChIP-ChIP_MESCs_Mouse1.24000605
73TBX3_20139965_ChIP-Seq_ESCs_Mouse1.22941001
74ESR1_21235772_ChIP-Seq_MCF-7_Human1.22768442
75* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.22534728
76STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.22105357
77TBX3_20139965_ChIP-Seq_MESCs_Mouse1.21703136
78* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.21086799
79NANOG_16153702_ChIP-ChIP_HESCs_Human1.19401743
80* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.18097365
81DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.17623314
82* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.17028867
83TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.16884695
84PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.16278801
85CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.15876252
86SALL4_18804426_ChIP-ChIP_XEN_Mouse1.14683363
87KDM2B_26808549_Chip-Seq_DND41_Human1.14657798
88TCF3_18692474_ChIP-Seq_MESCs_Mouse1.14531107
89GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14018639
90HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.13278926
91RUNX1_27514584_Chip-Seq_MCF-7_Human1.13037034
92FOXA2_19822575_ChIP-Seq_HepG2_Human1.12095208
93AHR_22903824_ChIP-Seq_MCF-7_Human1.11081311
94ESR1_20079471_ChIP-ChIP_T-47D_Human1.10593851
95SMC4_20622854_ChIP-Seq_HELA_Human1.09656884
96KAP1_27257070_Chip-Seq_ESCs_Mouse1.09055756
97GATA1_26923725_Chip-Seq_HPCs_Mouse1.08856383
98RING1B_27294783_Chip-Seq_ESCs_Mouse1.08635535
99OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.08182580
100RING1B_27294783_Chip-Seq_NPCs_Mouse1.08066922
101EZH2_27294783_Chip-Seq_ESCs_Mouse1.07894863
102TCF3_18692474_ChIP-Seq_MEFs_Mouse1.07335640
103SOX2_18692474_ChIP-Seq_MEFs_Mouse1.06794856
104ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05441125
105STAT6_21828071_ChIP-Seq_BEAS2B_Human1.04686643
106PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.04236893
107JARID2_20064375_ChIP-Seq_MESCs_Mouse1.04035712
108NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.03465291
109TRIM28_21343339_ChIP-Seq_HEK293_Human1.03341399
110THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.03163255
111SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.02963956
112RARG_19884340_ChIP-ChIP_MEFs_Mouse1.02931217
113* PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.02924370
114TP53_20018659_ChIP-ChIP_R1E_Mouse1.02645549
115TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.01632330
116TET1_21490601_ChIP-Seq_MESCs_Mouse1.00944334
117* NANOG_16518401_ChIP-PET_MESCs_Mouse1.00887922
118SMAD3_21741376_ChIP-Seq_EPCs_Human1.00428510
119SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.99994224
120POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.99744400
121SOX2_16153702_ChIP-ChIP_HESCs_Human0.99125715
122KDM2B_26808549_Chip-Seq_JURKAT_Human0.99060161
123EP300_21415370_ChIP-Seq_HL-1_Mouse0.99029691
124GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.98973848
125TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.98545366
126* NANOG_18692474_ChIP-Seq_MESCs_Mouse0.98445626
127SOX2_18692474_ChIP-Seq_MESCs_Mouse0.98371555
128SOX2_27498859_Chip-Seq_STOMACH_Mouse0.96894423
129NANOG_18692474_ChIP-Seq_MEFs_Mouse0.96240094
130EZH2_27304074_Chip-Seq_ESCs_Mouse0.95191059
131CDX2_20551321_ChIP-Seq_CACO-2_Human0.93833125
132* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.93161660
133P300_27058665_Chip-Seq_ZR-75-30cells_Human0.93121155
134SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.91699872
135BMI1_23680149_ChIP-Seq_NPCS_Mouse0.91566292
136CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.91385341
137SOX3_22085726_ChIP-Seq_NPCs_Mouse0.89234825
138SMAD3_21741376_ChIP-Seq_ESCs_Human0.88832271
139RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.87914443
140SOX2_18555785_ChIP-Seq_MESCs_Mouse0.87762763

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.70518112
2MP0010234_abnormal_vibrissa_follicle4.02017200
3MP0002254_reproductive_system_inflammat3.91249441
4MP0005360_urolithiasis3.79572348
5MP0003283_abnormal_digestive_organ3.40083638
6MP0005085_abnormal_gallbladder_physiolo3.37165019
7MP0003941_abnormal_skin_development3.22943883
8MP0002139_abnormal_hepatobiliary_system3.20895932
9MP0002822_catalepsy3.14089045
10MP0002163_abnormal_gland_morphology2.77300986
11MP0005365_abnormal_bile_salt2.77158482
12MP0008004_abnormal_stomach_pH2.52218627
13MP0003635_abnormal_synaptic_transmissio2.45159827
14MP0002909_abnormal_adrenal_gland2.40683373
15MP0004270_analgesia2.37067339
16MP0000566_synostosis2.27736788
17MP0005379_endocrine/exocrine_gland_phen2.25448456
18MP0009697_abnormal_copulation2.22223169
19MP0004264_abnormal_extraembryonic_tissu2.12229304
20MP0004858_abnormal_nervous_system2.11767772
21MP0003705_abnormal_hypodermis_morpholog2.10241906
22MP0001849_ear_inflammation2.07837663
23MP0000516_abnormal_urinary_system2.05611207
24MP0005367_renal/urinary_system_phenotyp2.05611207
25MP0010368_abnormal_lymphatic_system2.03334915
26MP0002063_abnormal_learning/memory/cond2.00028020
27MP0009780_abnormal_chondrocyte_physiolo1.94682848
28MP0003385_abnormal_body_wall1.90969093
29MP0003252_abnormal_bile_duct1.90110459
30MP0010329_abnormal_lipoprotein_level1.81283262
31MP0003567_abnormal_fetal_cardiomyocyte1.79081152
32MP0004272_abnormal_basement_membrane1.72013295
33MP0003122_maternal_imprinting1.69426776
34MP0008875_abnormal_xenobiotic_pharmacok1.67988950
35MP0001666_abnormal_nutrient_absorption1.67380169
36MP0003136_yellow_coat_color1.64803986
37MP0009745_abnormal_behavioral_response1.64127055
38MP0003329_amyloid_beta_deposits1.63505333
39MP0008961_abnormal_basal_metabolism1.62691985
40MP0003075_altered_response_to1.55925712
41MP0002064_seizures1.52915985
42MP0003806_abnormal_nucleotide_metabolis1.52438813
43MP0002084_abnormal_developmental_patter1.51406168
44MP0005623_abnormal_meninges_morphology1.50202055
45MP0003119_abnormal_digestive_system1.49877345
46MP0006276_abnormal_autonomic_nervous1.48623607
47MP0004885_abnormal_endolymph1.48567940
48MP0002572_abnormal_emotion/affect_behav1.42078447
49MP0004019_abnormal_vitamin_homeostasis1.42063935
50MP0002653_abnormal_ependyma_morphology1.42022940
51MP0003879_abnormal_hair_cell1.38298892
52MP0005257_abnormal_intraocular_pressure1.35927014
53MP0002697_abnormal_eye_size1.35210237
54MP0002796_impaired_skin_barrier1.35090554
55MP0005647_abnormal_sex_gland1.32899928
56MP0002138_abnormal_hepatobiliary_system1.31349213
57MP0000647_abnormal_sebaceous_gland1.26702107
58MP0000428_abnormal_craniofacial_morphol1.26105727
59MP0005332_abnormal_amino_acid1.25095918
60MP0003195_calcinosis1.24197323
61MP0003937_abnormal_limbs/digits/tail_de1.23719699
62MP0001346_abnormal_lacrimal_gland1.21812979
63MP0002234_abnormal_pharynx_morphology1.18549425
64MP0000678_abnormal_parathyroid_gland1.16542464
65MP0009046_muscle_twitch1.14527317
66MP0009672_abnormal_birth_weight1.13670840
67MP0002085_abnormal_embryonic_tissue1.13262032
68MP0003880_abnormal_central_pattern1.12973296
69MP0002233_abnormal_nose_morphology1.12778297
70MP0001486_abnormal_startle_reflex1.12490586
71MP0005380_embryogenesis_phenotype1.11601722
72MP0001672_abnormal_embryogenesis/_devel1.11601722
73MP0001919_abnormal_reproductive_system1.10892117
74MP0001984_abnormal_olfaction1.10589434
75MP0008872_abnormal_physiological_respon1.08904431
76MP0004811_abnormal_neuron_physiology1.08542444
77MP0004043_abnormal_pH_regulation1.08371172
78MP0000467_abnormal_esophagus_morphology1.06259413
79MP0005167_abnormal_blood-brain_barrier1.05576107
80MP0001188_hyperpigmentation1.04582201
81MP0002086_abnormal_extraembryonic_tissu1.03706576
82MP0000462_abnormal_digestive_system1.03328260
83MP0009840_abnormal_foam_cell1.02411542
84MP0005670_abnormal_white_adipose1.01724835
85MP0003123_paternal_imprinting1.01151315
86MP0009703_decreased_birth_body1.00577977
87MP0002272_abnormal_nervous_system1.00128976
88MP0001730_embryonic_growth_arrest0.98814185
89MP0002118_abnormal_lipid_homeostasis0.98303269
90MP0002876_abnormal_thyroid_physiology0.97795203
91MP0003633_abnormal_nervous_system0.96802420
92MP0002111_abnormal_tail_morphology0.95558401
93MP0003936_abnormal_reproductive_system0.95066343
94MP0004782_abnormal_surfactant_physiolog0.94714592
95MP0006292_abnormal_olfactory_placode0.93976349
96MP0005083_abnormal_biliary_tract0.93157902
97MP0003115_abnormal_respiratory_system0.92580925
98MP0003984_embryonic_growth_retardation0.91724375
99MP0005076_abnormal_cell_differentiation0.91692482
100MP0003890_abnormal_embryonic-extraembry0.91463057
101MP0001286_abnormal_eye_development0.91132851
102MP0003638_abnormal_response/metabolism_0.89799317
103MP0002734_abnormal_mechanical_nocicepti0.89691180
104MP0002089_abnormal_postnatal_growth/wei0.89477612
105MP0010678_abnormal_skin_adnexa0.88752408
106MP0000470_abnormal_stomach_morphology0.88686433
107MP0000955_abnormal_spinal_cord0.88214211
108MP0004133_heterotaxia0.87602591
109MP0001501_abnormal_sleep_pattern0.87561130
110MP0002733_abnormal_thermal_nociception0.86991308
111MP0003861_abnormal_nervous_system0.86444360
112MP0002088_abnormal_embryonic_growth/wei0.86279649
113MP0010030_abnormal_orbit_morphology0.86011782
114MP0001348_abnormal_lacrimal_gland0.85471529
115MP0000534_abnormal_ureter_morphology0.84345030
116MP0008874_decreased_physiological_sensi0.83239975
117MP0003935_abnormal_craniofacial_develop0.82113892
118MP0002925_abnormal_cardiovascular_devel0.81906523
119MP0000579_abnormal_nail_morphology0.80639241
120MP0004085_abnormal_heartbeat0.79042952
121MP0003011_delayed_dark_adaptation0.78882932
122MP0009384_cardiac_valve_regurgitation0.78652105
123MP0002098_abnormal_vibrissa_morphology0.78474633
124MP0003566_abnormal_cell_adhesion0.78451927
125MP0004957_abnormal_blastocyst_morpholog0.77772068
126MP0002078_abnormal_glucose_homeostasis0.77263689
127MP0000537_abnormal_urethra_morphology0.76537841
128MP0000049_abnormal_middle_ear0.75576906
129MP0008569_lethality_at_weaning0.75511161
130MP0000604_amyloidosis0.74749413
131MP0000609_abnormal_liver_physiology0.74533854
132MP0003943_abnormal_hepatobiliary_system0.74432014
133MP0005275_abnormal_skin_tensile0.73518564
134MP0001968_abnormal_touch/_nociception0.72560410
135MP0002069_abnormal_eating/drinking_beha0.72508304
136MP0001440_abnormal_grooming_behavior0.72123029
137MP0003121_genomic_imprinting0.71166070
138MP0008932_abnormal_embryonic_tissue0.71104477
139MP0001661_extended_life_span0.70519225
140MP0003942_abnormal_urinary_system0.70518854
141MP0004130_abnormal_muscle_cell0.69446384
142MP0005248_abnormal_Harderian_gland0.69356503
143MP0001177_atelectasis0.69090194
144MP0002249_abnormal_larynx_morphology0.68874610
145MP0003631_nervous_system_phenotype0.68308988
146MP0003878_abnormal_ear_physiology0.67580585
147MP0005377_hearing/vestibular/ear_phenot0.67580585
148MP0002066_abnormal_motor_capabilities/c0.67161650
149MP0003959_abnormal_lean_body0.66472027
150MP0004233_abnormal_muscle_weight0.65669192
151* MP0003453_abnormal_keratinocyte_physiol0.65599528
152MP0000639_abnormal_adrenal_gland0.65120317
153MP0002938_white_spotting0.64760825
154MP0005535_abnormal_body_temperature0.64343209
155MP0000266_abnormal_heart_morphology0.62779652
156MP0010352_gastrointestinal_tract_polyps0.62168375
157MP0005187_abnormal_penis_morphology0.62060408
158MP0002877_abnormal_melanocyte_morpholog0.61867441
159MP0002557_abnormal_social/conspecific_i0.61370109
160MP0005319_abnormal_enzyme/_coenzyme0.61003532
161MP0004185_abnormal_adipocyte_glucose0.60982787
162MP0001697_abnormal_embryo_size0.60952649
163MP0010630_abnormal_cardiac_muscle0.60660392
164MP0002152_abnormal_brain_morphology0.59526465
165MP0008995_early_reproductive_senescence0.58741245
166MP0002184_abnormal_innervation0.57973432
167MP0005499_abnormal_olfactory_system0.57850546
168MP0005394_taste/olfaction_phenotype0.57850546
169MP0009643_abnormal_urine_homeostasis0.57751259
170MP0000762_abnormal_tongue_morphology0.57361693
171MP0002081_perinatal_lethality0.55513701
172MP0002080_prenatal_lethality0.54662804

Predicted human phenotypes

RankGene SetZ-score
1Abnormal pancreas size (HP:0012094)4.86009855
2Abdominal situs inversus (HP:0003363)4.57005410
3Abnormality of abdominal situs (HP:0011620)4.57005410
4Double outlet right ventricle (HP:0001719)4.43509766
5Congenital malformation of the right heart (HP:0011723)4.43509766
6Myokymia (HP:0002411)4.26150923
7Abnormality of the lower motor neuron (HP:0002366)4.24885669
8Bilateral microphthalmos (HP:0007633)4.09126892
9Abnormal connection of the cardiac segments (HP:0011545)3.97319908
10Abnormal ventriculo-arterial connection (HP:0011563)3.97319908
11Transposition of the great arteries (HP:0001669)3.97319908
12Intrahepatic cholestasis (HP:0001406)3.49794279
13Right ventricular cardiomyopathy (HP:0011663)3.31146058
14Abnormality of monocarboxylic acid metabolism (HP:0010996)3.25566266
15Anal stenosis (HP:0002025)3.24707494
16Alacrima (HP:0000522)3.21350417
17Abnormality of aromatic amino acid family metabolism (HP:0004338)3.20976198
18Abnormality of the aortic arch (HP:0012303)3.10995038
19Deep venous thrombosis (HP:0002625)3.08421049
20Turricephaly (HP:0000262)3.08177533
21Focal motor seizures (HP:0011153)3.04727779
22Visual hallucinations (HP:0002367)2.99348993
23Absent eyebrow (HP:0002223)2.88864876
24Anophthalmia (HP:0000528)2.81082897
25Focal seizures (HP:0007359)2.79124561
26Bifid tongue (HP:0010297)2.74826243
27Xanthomatosis (HP:0000991)2.73829123
28Anosmia (HP:0000458)2.72640025
29Intestinal atresia (HP:0011100)2.70338415
30Esophageal atresia (HP:0002032)2.66843669
31Gout (HP:0001997)2.64228784
32Resting tremor (HP:0002322)2.64147876
33Ventricular fibrillation (HP:0001663)2.63120958
34Ankyloglossia (HP:0010296)2.62453094
35Hyperinsulinemic hypoglycemia (HP:0000825)2.61655854
36Labial hypoplasia (HP:0000066)2.60954906
37Oligodactyly (hands) (HP:0001180)2.57787294
38Ependymoma (HP:0002888)2.57290132
39Choanal stenosis (HP:0000452)2.57037531
40Bicornuate uterus (HP:0000813)2.54872415
41Ketoacidosis (HP:0001993)2.53605757
42Myelomeningocele (HP:0002475)2.52902009
43Annular pancreas (HP:0001734)2.51077552
44Chin dimple (HP:0010751)2.50965020
45Absent radius (HP:0003974)2.44881762
46Abnormality of the astrocytes (HP:0100707)2.44613419
47Astrocytoma (HP:0009592)2.44613419
48Ketosis (HP:0001946)2.44417538
49Hypoplastic female external genitalia (HP:0012815)2.44105873
50Fused cervical vertebrae (HP:0002949)2.41287496
51Milia (HP:0001056)2.38847348
52Hypobetalipoproteinemia (HP:0003563)2.38340367
53Status epilepticus (HP:0002133)2.37796207
54Abnormality of glutamine family amino acid metabolism (HP:0010902)2.36549256
55Horseshoe kidney (HP:0000085)2.35685928
56Decreased lacrimation (HP:0000633)2.35314569
57Abnormality of the dental pulp (HP:0006479)2.34437014
58Abnormality of the dental root (HP:0006486)2.33578002
59Taurodontia (HP:0000679)2.33578002
60Abnormality of permanent molar morphology (HP:0011071)2.33578002
61Amelogenesis imperfecta (HP:0000705)2.32305230
62Cutaneous finger syndactyly (HP:0010554)2.28912111
63Abnormality of the fetal cardiovascular system (HP:0010948)2.25720691
64Abnormal umbilical cord blood vessels (HP:0011403)2.25720691
65Single umbilical artery (HP:0001195)2.25720691
66Aplasia involving forearm bones (HP:0009822)2.25596719
67Absent forearm bone (HP:0003953)2.25596719
68Cutaneous syndactyly (HP:0012725)2.25092524
69Abnormality of molar (HP:0011077)2.24557667
70Abnormality of molar morphology (HP:0011070)2.24557667
71Aplasia/Hypoplasia of the sacrum (HP:0008517)2.23856767
72Spastic diplegia (HP:0001264)2.23347191
73Ectopic anus (HP:0004397)2.21170910
74Dysmetric saccades (HP:0000641)2.19046710
75Abnormal social behavior (HP:0012433)2.16364189
76Impaired social interactions (HP:0000735)2.16364189
77Abnormality of the Achilles tendon (HP:0005109)2.16024943
78Action tremor (HP:0002345)2.15546487
79Renal hypoplasia (HP:0000089)2.11818473
80Hyperglycinuria (HP:0003108)2.09004271
81Torticollis (HP:0000473)2.08613899
82Insomnia (HP:0100785)2.07415954
83Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.06481088
84Shawl scrotum (HP:0000049)2.06220458
85Hyperammonemia (HP:0001987)2.05977654
86Preauricular pit (HP:0004467)2.04764099
87Periauricular skin pits (HP:0100277)2.04764099
88Intention tremor (HP:0002080)2.04619200
89Postural instability (HP:0002172)2.04607336
90Distal upper limb amyotrophy (HP:0007149)2.04101298
91Upper limb amyotrophy (HP:0009129)2.04101298
92Epileptic encephalopathy (HP:0200134)2.04008781
93Bifid scrotum (HP:0000048)2.03209647
94Impaired vibration sensation in the lower limbs (HP:0002166)2.03085471
95Preaxial foot polydactyly (HP:0001841)2.02139423
96Short humerus (HP:0005792)2.01601314
97Aplasia/Hypoplasia of the spleen (HP:0010451)2.01310356
98Absence seizures (HP:0002121)2.01060235
99Cerebral inclusion bodies (HP:0100314)2.00844372
100Bronchomalacia (HP:0002780)2.00554186
101Hypoglycemic coma (HP:0001325)2.00522443
102Epidermoid cyst (HP:0200040)1.99807429
103Depression (HP:0000716)1.99435354
104Enlarged kidneys (HP:0000105)1.96799407
105Hypoglycemic seizures (HP:0002173)1.95918227
106Abnormality of the parathyroid morphology (HP:0011766)1.95383497
107Generalized tonic-clonic seizures (HP:0002069)1.95370278
108Aplasia/hypoplasia of the humerus (HP:0006507)1.95210159
109Dysdiadochokinesis (HP:0002075)1.94270334
110Onycholysis (HP:0001806)1.94130660
111Shallow orbits (HP:0000586)1.93971329
112Abnormality of sulfur amino acid metabolism (HP:0004339)1.92884686
113Abnormality of the pubic bones (HP:0003172)1.92705800
114Abnormality of glycine metabolism (HP:0010895)1.90641233
115Abnormality of serine family amino acid metabolism (HP:0010894)1.90641233
116Atonic seizures (HP:0010819)1.89819146
117Complement deficiency (HP:0004431)1.89585289
118Hepatoblastoma (HP:0002884)1.89447966
119Vertebral clefting (HP:0008428)1.88956700
120Pseudobulbar signs (HP:0002200)1.88369104
121Cupped ear (HP:0000378)1.88038769
122Achilles tendon contracture (HP:0001771)1.87898202
123Abnormality of the lacrimal duct (HP:0011481)1.87814289
124Absent hair (HP:0002298)1.87709524
125Hemiplegia (HP:0002301)1.87507658
126Poor eye contact (HP:0000817)1.86923565
127Hyperglycinemia (HP:0002154)1.86740171
128Septo-optic dysplasia (HP:0100842)1.86668548
129Abnormality of the middle phalanges of the toes (HP:0010183)1.86433680
130Gynecomastia (HP:0000771)1.85830690
131Focal dystonia (HP:0004373)1.85431630
132Patent foramen ovale (HP:0001655)1.85195810
133Pili torti (HP:0003777)1.85151665
134Ankle clonus (HP:0011448)1.83982991
135Hand muscle atrophy (HP:0009130)1.83966448
136Abnormality of the periventricular white matter (HP:0002518)1.83827927
137Pointed chin (HP:0000307)1.83712123
138Partial duplication of thumb phalanx (HP:0009944)1.83457952
139Progressive inability to walk (HP:0002505)1.82521602
140Abnormality of oral frenula (HP:0000190)1.82108696
141Mixed hearing impairment (HP:0000410)1.81870979
142Deep palmar crease (HP:0006191)1.81250584
143Abnormality of endocrine pancreas physiology (HP:0012093)1.80586142
144Abnormality of the pancreatic islet cells (HP:0006476)1.80586142
145Aqueductal stenosis (HP:0002410)1.80396123
146Hypochromic microcytic anemia (HP:0004840)1.78245265
147Abnormality of the antihelix (HP:0009738)1.77856635
148Abnormal sex determination (HP:0012244)1.77307000
149Sex reversal (HP:0012245)1.77307000
150Abnormality of the ischium (HP:0003174)1.77049939
151Skin nodule (HP:0200036)1.76780297
152Hypolipoproteinemia (HP:0010981)1.76353347
153Polygenic inheritance (HP:0010982)1.76228038
154Down-sloping shoulders (HP:0200021)1.75916511
155Hypergonadotropic hypogonadism (HP:0000815)1.75754116
156Tracheal stenosis (HP:0002777)1.75407521
157Craniofacial dystonia (HP:0012179)1.75317181
158Ureteral duplication (HP:0000073)1.75139446
159Dialeptic seizures (HP:0011146)1.74927791
160Lymphangioma (HP:0100764)1.74516510
161Hypoplasia of the ulna (HP:0003022)1.74138110
162Delayed CNS myelination (HP:0002188)1.74054754
163Pancreatic islet-cell hyperplasia (HP:0004510)1.73739496
164Neonatal onset (HP:0003623)1.73634260
165Hypsarrhythmia (HP:0002521)1.72403051
166Hemivertebrae (HP:0002937)1.70317407
167Long palpebral fissure (HP:0000637)1.69359794
168EEG with generalized epileptiform discharges (HP:0011198)1.68626400
169Late onset (HP:0003584)1.68577275
170Malnutrition (HP:0004395)1.67347723
171Microretrognathia (HP:0000308)1.67313187
172Midline defect of the nose (HP:0004122)1.66516124
173Epileptiform EEG discharges (HP:0011182)1.66261652
174Abnormal vertebral ossification (HP:0100569)1.65500919
175Urinary bladder sphincter dysfunction (HP:0002839)1.65372397
176Irritability (HP:0000737)1.65300236
177Partial duplication of the phalanx of hand (HP:0009999)1.64268694
178Asplenia (HP:0001746)1.64222161
179Impaired smooth pursuit (HP:0007772)1.64022372
180Fragile nails (HP:0001808)1.63945241
181Coronal craniosynostosis (HP:0004440)1.63638443
182Back pain (HP:0003418)1.63537357
183Vitreoretinal degeneration (HP:0000655)1.63444826
184Aplasia involving bones of the upper limbs (HP:0009823)1.63221216
185Aplasia of the phalanges of the hand (HP:0009802)1.63221216
186Aplasia involving bones of the extremities (HP:0009825)1.63221216
187Omphalocele (HP:0001539)1.63087362
188Hypogonadotrophic hypogonadism (HP:0000044)1.62419852
189Hyperglycemia (HP:0003074)1.61772026
190Impaired vibratory sensation (HP:0002495)1.61517006

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA43.96073832
2PBK3.95827120
3MAP3K93.70357266
4ERBB43.33348284
5TESK23.26382803
6DAPK23.26173645
7PRKD33.01042176
8MAPK152.52302754
9KSR22.46057597
10TNIK2.45933394
11NTRK32.42828837
12GRK12.41066689
13KDR2.36571116
14TYRO32.32142298
15PDK22.21485977
16SMG12.13634410
17PHKG22.09655916
18PHKG12.09655916
19NTRK12.05049111
20PAK62.04617699
21RIPK12.00423145
22ICK1.99774740
23DAPK11.92809669
24MAP3K21.89476342
25DDR21.69121019
26LATS21.66472834
27TRIB31.65502236
28STK381.65095213
29EPHA21.64722691
30CAMKK11.60921382
31MAP3K41.55397555
32TAOK11.52527310
33NEK11.44660504
34ACVR1B1.44428653
35PDGFRA1.41606629
36SIK11.37453441
37MINK11.29988990
38ALK1.29726619
39LATS11.28860141
40PKN21.28501942
41MAP2K41.27925187
42STK38L1.26430126
43ERN11.25705076
44FER1.22059308
45CDK121.21898473
46NLK1.21382810
47UHMK11.20657428
48PAK41.19116382
49STK161.15173481
50TTK1.14374467
51SCYL21.12238757
52BMX1.10806460
53STK41.10235226
54RPS6KA21.08869153
55PTK21.08537561
56MST41.08320913
57GRK51.07361212
58KSR11.03606653
59RET1.01058496
60NTRK20.99752907
61CDK50.99049638
62NME10.98866086
63LMTK20.98494672
64MAP3K10.95950636
65CASK0.95864824
66TRIM280.95369673
67MATK0.92198396
68CDC42BPA0.90888389
69PINK10.90055334
70DYRK20.89018505
71FGFR40.88313832
72PTK60.87640927
73STK30.82004572
74FGFR10.81831002
75AKT30.81132828
76ERBB20.80030598
77BCKDK0.78429618
78MAP3K100.75381635
79STK110.74605724
80WNK40.74305976
81ZAK0.74176380
82EEF2K0.73966690
83PDGFRB0.71961623
84MAP2K10.70253217
85SIK20.69629686
86MAP3K70.69200694
87ARAF0.68538772
88PAK30.67396143
89MAP3K130.66467668
90PRKCH0.66250909
91CAMK40.63049074
92PRKD20.62909738
93PLK40.60950524
94PRKCG0.58627165
95MKNK20.58483001
96RAF10.57211261
97MTOR0.57126569
98SGK2230.55814849
99SGK4940.55814849
100GRK60.54898829
101STK390.54372161
102DAPK30.53373689
103DYRK1B0.52910482
104OXSR10.52679603
105FGFR20.52446177
106PRKCI0.52340052
107CDK150.51594003
108MARK20.51579493
109SGK30.51320781
110PASK0.50506703
111INSRR0.50475975
112RPS6KL10.50087867
113RPS6KC10.50087867
114CAMK10.49779452
115RPS6KA30.48576636
116WNK30.48211639
117MET0.47645674
118TAF10.47606790
119CDK180.46765317
120JAK20.46118662
121HIPK20.45602899
122PDPK10.45526317
123MARK10.43977642
124PDK10.43514882
125FRK0.42819139
126SRC0.42208614
127CSNK1E0.42183181
128CDK11A0.42028942
129PRKCZ0.41823621
130CAMK2G0.41416842
131PAK20.41305290
132MAP2K20.41122029
133MAPK100.41102127
134CDK140.40934819
135ROCK20.40477487
136YES10.39769778
137RPS6KA60.39468294
138MAPK110.39003411
139RPS6KA10.38981855
140MAP3K60.38565553
141FGR0.38148542
142SGK10.38120785
143BMPR1B0.37756643
144MST1R0.37425461
145CDK70.35354074
146DMPK0.34856548
147CAMK1D0.33857027
148PRKG20.33030012
149MAPK90.32893902
150TGFBR10.31223835
151EPHB20.30180215
152GSK3B0.29913343
153PRKCE0.29863058
154AKT20.27243433
155PRKAA10.26532791
156CAMK1G0.25246995

Predicted pathways (KEGG)

RankGene SetZ-score
1Folate biosynthesis_Homo sapiens_hsa007904.57735317
2Nitrogen metabolism_Homo sapiens_hsa009104.51068939
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.86750986
4Ovarian steroidogenesis_Homo sapiens_hsa049132.86564144
5Arginine biosynthesis_Homo sapiens_hsa002202.56391289
6Primary bile acid biosynthesis_Homo sapiens_hsa001202.40349967
7Steroid hormone biosynthesis_Homo sapiens_hsa001402.28261929
8Basal cell carcinoma_Homo sapiens_hsa052172.25257258
9Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.07972849
10Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002502.02846925
11Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.02024511
12Synaptic vesicle cycle_Homo sapiens_hsa047211.99727859
13Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.87531118
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.84720778
15alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.78512987
16Vitamin digestion and absorption_Homo sapiens_hsa049771.78364151
17Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.73297891
18Bile secretion_Homo sapiens_hsa049761.71874209
19TGF-beta signaling pathway_Homo sapiens_hsa043501.67870720
20Insulin secretion_Homo sapiens_hsa049111.65540505
21Maturity onset diabetes of the young_Homo sapiens_hsa049501.64846782
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.54005163
23Amphetamine addiction_Homo sapiens_hsa050311.50563867
24Wnt signaling pathway_Homo sapiens_hsa043101.47558044
25Long-term potentiation_Homo sapiens_hsa047201.43603591
26Hedgehog signaling pathway_Homo sapiens_hsa043401.42845409
27Tryptophan metabolism_Homo sapiens_hsa003801.40885285
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.39677800
29ECM-receptor interaction_Homo sapiens_hsa045121.34689887
30GABAergic synapse_Homo sapiens_hsa047271.33905121
31Olfactory transduction_Homo sapiens_hsa047401.32881038
32Butanoate metabolism_Homo sapiens_hsa006501.32784733
33Cyanoamino acid metabolism_Homo sapiens_hsa004601.32553790
34Mineral absorption_Homo sapiens_hsa049781.26970008
35Salivary secretion_Homo sapiens_hsa049701.17719266
36Circadian entrainment_Homo sapiens_hsa047131.17536010
37Type II diabetes mellitus_Homo sapiens_hsa049301.17005195
38Axon guidance_Homo sapiens_hsa043601.16770589
39Biosynthesis of amino acids_Homo sapiens_hsa012301.16095948
40Gastric acid secretion_Homo sapiens_hsa049711.12375867
41Retinol metabolism_Homo sapiens_hsa008301.12217379
42Fatty acid degradation_Homo sapiens_hsa000711.11355720
43Aldosterone synthesis and secretion_Homo sapiens_hsa049251.09481021
44Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.09230833
45Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.09168428
46Glutamatergic synapse_Homo sapiens_hsa047241.08559319
47Cocaine addiction_Homo sapiens_hsa050301.08241591
48Nicotine addiction_Homo sapiens_hsa050331.05599496
49Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.05360397
50Dopaminergic synapse_Homo sapiens_hsa047281.02671440
51Fatty acid biosynthesis_Homo sapiens_hsa000611.00378332
52PPAR signaling pathway_Homo sapiens_hsa033201.00361240
53Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.00345708
54Linoleic acid metabolism_Homo sapiens_hsa005910.99936001
55Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.99207875
56Steroid biosynthesis_Homo sapiens_hsa001000.99095660
57Fat digestion and absorption_Homo sapiens_hsa049750.96481890
58mTOR signaling pathway_Homo sapiens_hsa041500.95700982
59Estrogen signaling pathway_Homo sapiens_hsa049150.94580252
60Protein digestion and absorption_Homo sapiens_hsa049740.92614269
61Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.91954856
62Adherens junction_Homo sapiens_hsa045200.88497096
63Fatty acid metabolism_Homo sapiens_hsa012120.87576549
64Selenocompound metabolism_Homo sapiens_hsa004500.87322119
65Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.87034875
66N-Glycan biosynthesis_Homo sapiens_hsa005100.86992120
67Glucagon signaling pathway_Homo sapiens_hsa049220.86942524
68Cholinergic synapse_Homo sapiens_hsa047250.86842994
69Morphine addiction_Homo sapiens_hsa050320.86819353
70Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.85847091
71Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.85794472
72GnRH signaling pathway_Homo sapiens_hsa049120.85664130
73Sulfur relay system_Homo sapiens_hsa041220.85536634
74Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.85249391
75Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.84333543
76Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.84203258
77PI3K-Akt signaling pathway_Homo sapiens_hsa041510.82438710
78Pentose and glucuronate interconversions_Homo sapiens_hsa000400.82366328
79Gap junction_Homo sapiens_hsa045400.79563017
80Carbohydrate digestion and absorption_Homo sapiens_hsa049730.78870385
81Bladder cancer_Homo sapiens_hsa052190.78632815
82Phototransduction_Homo sapiens_hsa047440.78263653
83Prion diseases_Homo sapiens_hsa050200.77485565
84Oxytocin signaling pathway_Homo sapiens_hsa049210.76825430
85Phenylalanine metabolism_Homo sapiens_hsa003600.75448921
86Thyroid hormone synthesis_Homo sapiens_hsa049180.75264308
87Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.74501055
88Glioma_Homo sapiens_hsa052140.74451735
89Renin secretion_Homo sapiens_hsa049240.73736846
90Ether lipid metabolism_Homo sapiens_hsa005650.73671822
91Melanogenesis_Homo sapiens_hsa049160.72590342
92Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.72519418
93Dorso-ventral axis formation_Homo sapiens_hsa043200.72447558
94Complement and coagulation cascades_Homo sapiens_hsa046100.72233805
95Lysine degradation_Homo sapiens_hsa003100.70465367
96Hippo signaling pathway_Homo sapiens_hsa043900.68975045
97beta-Alanine metabolism_Homo sapiens_hsa004100.65849032
98ErbB signaling pathway_Homo sapiens_hsa040120.64342245
99Sulfur metabolism_Homo sapiens_hsa009200.63892188
100Starch and sucrose metabolism_Homo sapiens_hsa005000.63693049
101Rap1 signaling pathway_Homo sapiens_hsa040150.62672162
102Insulin resistance_Homo sapiens_hsa049310.62166753
103Carbon metabolism_Homo sapiens_hsa012000.62011127
104Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.61847250
105Longevity regulating pathway - mammal_Homo sapiens_hsa042110.61083483
106Fructose and mannose metabolism_Homo sapiens_hsa000510.60863673
107Central carbon metabolism in cancer_Homo sapiens_hsa052300.60831493
108Vitamin B6 metabolism_Homo sapiens_hsa007500.60649287
109Histidine metabolism_Homo sapiens_hsa003400.60528342
110Pyruvate metabolism_Homo sapiens_hsa006200.58311021
111Melanoma_Homo sapiens_hsa052180.57195267
112Cysteine and methionine metabolism_Homo sapiens_hsa002700.56752169
113Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.56449718
114Ras signaling pathway_Homo sapiens_hsa040140.56173101
115Phosphatidylinositol signaling system_Homo sapiens_hsa040700.55345109
116Insulin signaling pathway_Homo sapiens_hsa049100.54741653
117Pancreatic secretion_Homo sapiens_hsa049720.54552479
118Galactose metabolism_Homo sapiens_hsa000520.54547563
119Tight junction_Homo sapiens_hsa045300.54296918
120Thyroid hormone signaling pathway_Homo sapiens_hsa049190.54253906
121Glycerolipid metabolism_Homo sapiens_hsa005610.54105874
122Endometrial cancer_Homo sapiens_hsa052130.52792064
123Fatty acid elongation_Homo sapiens_hsa000620.52703223
124Calcium signaling pathway_Homo sapiens_hsa040200.51571804
125Proteoglycans in cancer_Homo sapiens_hsa052050.51557739
126Long-term depression_Homo sapiens_hsa047300.51426147
127Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.51411164
128cAMP signaling pathway_Homo sapiens_hsa040240.50409623
129Caffeine metabolism_Homo sapiens_hsa002320.50339638
130AMPK signaling pathway_Homo sapiens_hsa041520.50289972
131Taste transduction_Homo sapiens_hsa047420.49945656
132Propanoate metabolism_Homo sapiens_hsa006400.49440732
133Tyrosine metabolism_Homo sapiens_hsa003500.48489079
134Protein export_Homo sapiens_hsa030600.47205358
135Pathways in cancer_Homo sapiens_hsa052000.46378283
136Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45250143
137Arginine and proline metabolism_Homo sapiens_hsa003300.44516187
138Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.44300362
139Thyroid cancer_Homo sapiens_hsa052160.43586733
140Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.43201949
141Focal adhesion_Homo sapiens_hsa045100.41623204
142Metabolic pathways_Homo sapiens_hsa011000.40755252
143ABC transporters_Homo sapiens_hsa020100.40190718
144Arachidonic acid metabolism_Homo sapiens_hsa005900.39404261
145Sphingolipid metabolism_Homo sapiens_hsa006000.39316478
146Glutathione metabolism_Homo sapiens_hsa004800.37441964
147Notch signaling pathway_Homo sapiens_hsa043300.36049569
148Chemical carcinogenesis_Homo sapiens_hsa052040.33943736

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