ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	signal peptide processing (GO:0006465)	6.50268241
2	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	6.10855670
3	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.81358417
4	ATP synthesis coupled proton transport (GO:0015986)	5.81358417
5	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	5.70612168
6	ribosomal small subunit assembly (GO:0000028)	5.25011812
7	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	5.16323668
8	cotranslational protein targeting to membrane (GO:0006613)	5.15366704
9	respiratory electron transport chain (GO:0022904)	5.11670108
10	protein targeting to ER (GO:0045047)	5.08158015
11	electron transport chain (GO:0022900)	5.02776220
12	protein localization to endoplasmic reticulum (GO:0070972)	4.90925741
13	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.80914377
14	protein complex biogenesis (GO:0070271)	4.70795240
15	DNA deamination (GO:0045006)	4.61123392
16	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.41273014
17	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.41273014
18	NADH dehydrogenase complex assembly (GO:0010257)	4.41273014
19	GDP-mannose metabolic process (GO:0019673)	4.39971438
20	respiratory chain complex IV assembly (GO:0008535)	4.34784290
21	protein neddylation (GO:0045116)	4.25284274
22	ribosomal small subunit biogenesis (GO:0042274)	4.23006530
23	mitochondrial respiratory chain complex assembly (GO:0033108)	4.22775065
24	viral transcription (GO:0019083)	4.21492635
25	proteasome assembly (GO:0043248)	4.10501600
26	GTP biosynthetic process (GO:0006183)	4.09560930
27	translational termination (GO:0006415)	4.08670575
28	chaperone-mediated protein transport (GO:0072321)	4.01529036
29	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	3.96151849
30	platelet dense granule organization (GO:0060155)	3.92738450
31	translation (GO:0006412)	3.87175516
32	cullin deneddylation (GO:0010388)	3.86197109
33	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	3.85451099
34	COPI coating of Golgi vesicle (GO:0048205)	3.84264008
35	Golgi transport vesicle coating (GO:0048200)	3.84264008
36	protein deneddylation (GO:0000338)	3.81691166
37	cytochrome complex assembly (GO:0017004)	3.79853016
38	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	3.74895263
39	regulation of mitochondrial translation (GO:0070129)	3.70381115
40	regulation of cellular amino acid metabolic process (GO:0006521)	3.67168484
41	rRNA modification (GO:0000154)	3.66148459
42	protein maturation by protein folding (GO:0022417)	3.65777786
43	peptidyl-histidine modification (GO:0018202)	3.63987531
44	antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)	3.62746982
45	guanosine-containing compound biosynthetic process (GO:1901070)	3.62283661
46	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.61405795
47	positive regulation of ligase activity (GO:0051351)	3.60572261
48	mannosylation (GO:0097502)	3.56595867
49	translational elongation (GO:0006414)	3.55527256
50	sequestering of actin monomers (GO:0042989)	3.54385942
51	hydrogen transport (GO:0006818)	3.52049013
52	maintenance of protein localization in endoplasmic reticulum (GO:0035437)	3.51102826
53	UTP biosynthetic process (GO:0006228)	3.48486072
54	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.44729683
55	termination of RNA polymerase III transcription (GO:0006386)	3.44007412
56	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.44007412
57	establishment of integrated proviral latency (GO:0075713)	3.43358609
58	maturation of SSU-rRNA (GO:0030490)	3.42415559
59	viral life cycle (GO:0019058)	3.39364327
60	protein retention in ER lumen (GO:0006621)	3.38749983
61	protein targeting to membrane (GO:0006612)	3.33804863
62	dolichol-linked oligosaccharide biosynthetic process (GO:0006488)	3.31645721
63	establishment of viral latency (GO:0019043)	3.31341067
64	CTP metabolic process (GO:0046036)	3.29863330
65	CTP biosynthetic process (GO:0006241)	3.29863330
66	antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)	3.27757990
67	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.26145156
68	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.25953772
69	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.25332396
70	mitochondrial transport (GO:0006839)	3.24030506
71	regulation of ubiquitin-protein transferase activity (GO:0051438)	3.22682172
72	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	3.22114497
73	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	3.21932478
74	negative regulation of ligase activity (GO:0051352)	3.21932478
75	protein targeting to mitochondrion (GO:0006626)	3.17669707
76	cellular protein complex disassembly (GO:0043624)	3.15396756
77	positive regulation of cell cycle arrest (GO:0071158)	3.14517538
78	regulation of ligase activity (GO:0051340)	3.12940791
79	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	3.12569151
80	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	3.12569151
81	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	3.12289290
82	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	3.12289290
83	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	3.12289290
84	oxidative phosphorylation (GO:0006119)	3.11320259
85	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.10695637
86	nucleotide transmembrane transport (GO:1901679)	3.09991596
87	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.09236623
88	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	3.07979460
89	hydrogen ion transmembrane transport (GO:1902600)	3.07931837
90	nucleoside triphosphate biosynthetic process (GO:0009142)	3.06795549
91	7-methylguanosine mRNA capping (GO:0006370)	3.06758361
92	DNA damage response, signal transduction by p53 class mediator (GO:0030330)	3.05936318
93	UTP metabolic process (GO:0046051)	3.05050127
94	establishment of protein localization to mitochondrion (GO:0072655)	3.04450111
95	regulation of oxidative phosphorylation (GO:0002082)	3.02305186
96	ATP biosynthetic process (GO:0006754)	3.02066013
97	translational initiation (GO:0006413)	3.00996795
98	7-methylguanosine RNA capping (GO:0009452)	2.99801968
99	RNA capping (GO:0036260)	2.99801968
100	negative regulation of protein ubiquitination (GO:0031397)	2.99274214
101	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.98562691
102	cellular component biogenesis (GO:0044085)	2.97728560
103	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.97214696
104	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.95739139
105	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.95739139
106	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.94309245
107	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.94309245
108	intracellular protein transmembrane import (GO:0044743)	2.93713435
109	inner mitochondrial membrane organization (GO:0007007)	2.92411113
110	protein peptidyl-prolyl isomerization (GO:0000413)	2.91896818
111	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	2.90388274
112	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.90266607
113	spliceosomal snRNP assembly (GO:0000387)	2.90122684
114	purine ribonucleoside monophosphate biosynthetic process (GO:0009168)	2.89522778
115	purine nucleoside monophosphate biosynthetic process (GO:0009127)	2.89522778
116	regulation of cellular amine metabolic process (GO:0033238)	2.89398835
117	protein-cofactor linkage (GO:0018065)	2.87896636
118	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.87001752
119	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.86091523
120	ribosomal large subunit biogenesis (GO:0042273)	2.80301240
121	metallo-sulfur cluster assembly (GO:0031163)	2.80240797
122	iron-sulfur cluster assembly (GO:0016226)	2.80240797
123	deoxyribonucleoside diphosphate metabolic process (GO:0009186)	2.79729313
124	protein localization to mitochondrion (GO:0070585)	2.79324828
125	proton transport (GO:0015992)	2.78996951

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	5.11557199
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	5.09437999
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.81239988
4	* JARID1A_20064375_ChIP-Seq_MESCs_Mouse	4.28874643
5	* EST1_17652178_ChIP-ChIP_JURKAT_Human	4.03774688
6	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.76734450
7	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.53937085
8	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	3.53504863
9	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	3.30834996
10	CREB1_15753290_ChIP-ChIP_HEK293T_Human	3.30159547
11	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.18489437
12	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	3.18220422
13	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.09669779
14	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.03392272
15	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.99621443
16	* SRF_21415370_ChIP-Seq_HL-1_Mouse	2.94163189
17	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.75656053
18	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.63189750
19	VDR_23849224_ChIP-Seq_CD4+_Human	2.56997374
20	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	2.38449028
21	DCP1A_22483619_ChIP-Seq_HELA_Human	2.37503882
22	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.34466782
23	E2F1_18555785_ChIP-Seq_MESCs_Mouse	2.21619948
24	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	2.09043699
25	ELK1_19687146_ChIP-ChIP_HELA_Human	2.05907083
26	* THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.05733054
27	FOXP3_21729870_ChIP-Seq_TREG_Human	2.04354273
28	YY1_21170310_ChIP-Seq_MESCs_Mouse	2.01446966
29	* ELK1_22589737_ChIP-Seq_MCF10A_Human	1.99358166
30	* GABP_19822575_ChIP-Seq_HepG2_Human	1.98384005
31	* MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.96179952
32	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.93588271
33	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.91966334
34	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.89325984
35	XRN2_22483619_ChIP-Seq_HELA_Human	1.88366463
36	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.72766232
37	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.71442492
38	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.69898183
39	TTF2_22483619_ChIP-Seq_HELA_Human	1.64288567
40	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.63927903
41	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.62772201
42	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.57777135
43	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.51852984
44	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.46800714
45	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.46389256
46	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.43542709
47	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.41078608
48	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.38620989
49	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.37084711
50	* NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.36303224
51	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.33954259
52	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.31512044
53	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.27726142
54	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.27026489
55	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.24897436
56	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.21753240
57	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.21459556
58	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.18674969
59	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.18278841
60	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.12225156
61	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.10129506
62	MEIS1_20887958_ChIP-Seq_HPC-7_Mouse	1.10036882
63	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.08602808
64	HTT_18923047_ChIP-ChIP_STHdh_Human	1.07988813
65	* HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.06069327
66	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.05066194
67	* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	1.03676984
68	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.03358663
69	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.02040570
70	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.00490894
71	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.00092904
72	SRY_22984422_ChIP-ChIP_TESTIS_Rat	0.99617663
73	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.98994988
74	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.98690440
75	* SPI1_23547873_ChIP-Seq_NB4_Human	0.98158689
76	STAT1_20625510_ChIP-Seq_HELA_Human	0.97162438
77	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.96458394
78	* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	0.95127809
79	VDR_22108803_ChIP-Seq_LS180_Human	0.93837114
80	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	0.93431907
81	MYC_18940864_ChIP-ChIP_HL60_Human	0.92793889
82	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	0.92714657
83	* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.92386606
84	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.92154611
85	ELF5_23300383_ChIP-Seq_T47D_Human	0.91607290
86	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	0.90620657
87	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.90567160
88	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	0.90350819
89	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	0.89890075
90	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.89761433
91	SOX17_20123909_ChIP-Seq_XEN_Mouse	0.88695344
92	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	0.88408364
93	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.86709017
94	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	0.85097759
95	* PU.1_20513432_ChIP-Seq_Bcells_Mouse	0.84886519
96	STAT4_19710469_ChIP-ChIP_TH1__Mouse	0.84763371
97	* TBX5_21415370_ChIP-Seq_HL-1_Mouse	0.83472506
98	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.82810240
99	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.82810240
100	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	0.82109395
101	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.82071806
102	TP53_22573176_ChIP-Seq_HFKS_Human	0.81921104
103	TFEB_21752829_ChIP-Seq_HELA_Human	0.81715319
104	CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse	0.81557363
105	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.81194473
106	ERG_20517297_ChIP-Seq_VCAP_Human	0.80562092
107	IRF1_19129219_ChIP-ChIP_H3396_Human	0.80355080
108	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.80100963
109	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.79846883
110	AR_20517297_ChIP-Seq_VCAP_Human	0.79632926
111	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	0.78961611
112	KDM5A_27292631_Chip-Seq_BREAST_Human	0.78948713
113	CTCF_26484167_Chip-Seq_Bcells_Mouse	0.78464275
114	EWS_26573619_Chip-Seq_HEK293_Human	0.77584852
115	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.76597546
116	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.76330713
117	* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	0.76114483
118	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	0.75969739
119	NANOG_20526341_ChIP-Seq_ESCs_Human	0.75538781
120	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	0.75219922
121	EOMES_21245162_ChIP-Seq_HESCs_Human	0.74200901
122	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.73588050
123	NANOG_18358816_ChIP-ChIP_MESCs_Mouse	0.72871280
124	GATA1_22383799_ChIP-Seq_G1ME_Mouse	0.72735602
125	MYCN_18555785_ChIP-Seq_MESCs_Mouse	0.71600683
126	PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse	0.71275298
127	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.71071900
128	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.70314574
129	STAT3_1855785_ChIP-Seq_MESCs_Mouse	0.67028502
130	NANOG_19829295_ChIP-Seq_ESCs_Human	0.66912042

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	3.65756982
2	MP0010386_abnormal_urinary_bladder	3.17552259
3	MP0005379_endocrine/exocrine_gland_phen	3.00131942
4	MP0003186_abnormal_redox_activity	2.94591967
5	MP0003806_abnormal_nucleotide_metabolis	2.72424123
6	MP0002163_abnormal_gland_morphology	2.63374019
7	MP0004043_abnormal_pH_regulation	2.42652576
8	MP0003724_increased_susceptibility_to	2.39180110
9	MP0003786_premature_aging	2.35604509
10	MP0008875_abnormal_xenobiotic_pharmacok	2.32733131
11	MP0001529_abnormal_vocalization	2.32148267
12	MP0001986_abnormal_taste_sensitivity	2.30232030
13	MP0003195_calcinosis	2.26441751
14	MP0003693_abnormal_embryo_hatching	2.25055281
15	MP0008058_abnormal_DNA_repair	2.24607524
16	MP0002638_abnormal_pupillary_reflex	2.18119441
17	MP0002693_abnormal_pancreas_physiology	2.09059240
18	MP0001905_abnormal_dopamine_level	1.98184343
19	MP0006036_abnormal_mitochondrial_physio	1.96117005
20	MP0000372_irregular_coat_pigmentation	1.91802248
21	MP0005220_abnormal_exocrine_pancreas	1.86754381
22	MP0005671_abnormal_response_to	1.82536953
23	MP0003183_abnormal_peptide_metabolism	1.82322502
24	MP0005058_abnormal_lysosome_morphology	1.82162627
25	MP0002148_abnormal_hypersensitivity_rea	1.81750584
26	MP0002933_joint_inflammation	1.79847268
27	MP0005464_abnormal_platelet_physiology	1.79115370
28	MP0005408_hypopigmentation	1.77185271
29	MP0005636_abnormal_mineral_homeostasis	1.76188001
30	MP0006054_spinal_hemorrhage	1.75891801
31	MP0009333_abnormal_splenocyte_physiolog	1.74658494
32	MP0005084_abnormal_gallbladder_morpholo	1.72589752
33	MP0002876_abnormal_thyroid_physiology	1.72337512
34	MP0000358_abnormal_cell_content/	1.67407663
35	MP0001542_abnormal_bone_strength	1.66256952
36	MP0004147_increased_porphyrin_level	1.65336169
37	MP0001764_abnormal_homeostasis	1.64730473
38	MP0009785_altered_susceptibility_to	1.64388576
39	MP0002139_abnormal_hepatobiliary_system	1.60698270
40	MP0000013_abnormal_adipose_tissue	1.60147675
41	MP0002938_white_spotting	1.55626306
42	MP0005365_abnormal_bile_salt	1.53846404
43	MP0001944_abnormal_pancreas_morphology	1.53519891
44	MP0000678_abnormal_parathyroid_gland	1.52699328
45	MP0005410_abnormal_fertilization	1.47836982
46	MP0008438_abnormal_cutaneous_collagen	1.43956211
47	* MP0004957_abnormal_blastocyst_morpholog	1.43023334
48	MP0002132_abnormal_respiratory_system	1.42998323
49	MP0009697_abnormal_copulation	1.40208629
50	MP0000613_abnormal_salivary_gland	1.39062658
51	MP0006276_abnormal_autonomic_nervous	1.38079367
52	MP0010030_abnormal_orbit_morphology	1.37305576
53	MP0008007_abnormal_cellular_replicative	1.37222230
54	MP0009643_abnormal_urine_homeostasis	1.36319713
55	MP0001664_abnormal_digestion	1.35764782
56	MP0003866_abnormal_defecation	1.32511897
57	MP0001835_abnormal_antigen_presentation	1.29498307
58	MP0003950_abnormal_plasma_membrane	1.29034588
59	* MP0008932_abnormal_embryonic_tissue	1.28851018
60	MP0002282_abnormal_trachea_morphology	1.26658340
61	MP0008872_abnormal_physiological_respon	1.25754547
62	MP0005085_abnormal_gallbladder_physiolo	1.24810610
63	MP0000343_altered_response_to	1.24459740
64	MP0006072_abnormal_retinal_apoptosis	1.22186664
65	MP0003763_abnormal_thymus_physiology	1.21148965
66	MP0008995_early_reproductive_senescence	1.21127200
67	MP0005000_abnormal_immune_tolerance	1.21076405
68	MP0001984_abnormal_olfaction	1.19631766
69	MP0005025_abnormal_response_to	1.19592236
70	MP0005253_abnormal_eye_physiology	1.17184890
71	MP0001666_abnormal_nutrient_absorption	1.16116919
72	MP0003941_abnormal_skin_development	1.15915927
73	MP0008004_abnormal_stomach_pH	1.15265419
74	MP0000538_abnormal_urinary_bladder	1.13999597
75	MP0005075_abnormal_melanosome_morpholog	1.13495681
76	MP0002102_abnormal_ear_morphology	1.12269337
77	MP0005165_increased_susceptibility_to	1.11500907
78	MP0002090_abnormal_vision	1.11479511
79	MP0003718_maternal_effect	1.09773268
80	MP0001853_heart_inflammation	1.09616095
81	MP0003136_yellow_coat_color	1.09556642
82	MP0000462_abnormal_digestive_system	1.07467048
83	MP0004019_abnormal_vitamin_homeostasis	1.07350804
84	MP0000681_abnormal_thyroid_gland	1.06370532
85	MP0005360_urolithiasis	1.06200160
86	MP0005503_abnormal_tendon_morphology	1.05176116
87	MP0005645_abnormal_hypothalamus_physiol	1.04125777
88	MP0003656_abnormal_erythrocyte_physiolo	1.04090065
89	MP0002277_abnormal_respiratory_mucosa	1.04042698
90	MP0002234_abnormal_pharynx_morphology	1.03337299
91	MP0005083_abnormal_biliary_tract	1.02475035
92	MP0005387_immune_system_phenotype	1.01524794
93	MP0001790_abnormal_immune_system	1.01524794
94	MP0001533_abnormal_skeleton_physiology	0.98941164
95	MP0005409_darkened_coat_color	0.97333703
96	MP0000685_abnormal_immune_system	0.96741263
97	MP0008469_abnormal_protein_level	0.95319881
98	MP0002295_abnormal_pulmonary_circulatio	0.95034437
99	MP0008789_abnormal_olfactory_epithelium	0.94547413
100	MP0001756_abnormal_urination	0.94473189
101	MP0000230_abnormal_systemic_arterial	0.93429326
102	MP0002419_abnormal_innate_immunity	0.93389725
103	MP0005551_abnormal_eye_electrophysiolog	0.92463300
104	MP0004142_abnormal_muscle_tone	0.92079391
105	MP0001881_abnormal_mammary_gland	0.90309918
106	MP0001845_abnormal_inflammatory_respons	0.90183255
107	MP0006035_abnormal_mitochondrial_morpho	0.89941414
108	MP0004272_abnormal_basement_membrane	0.89849301
109	MP0002723_abnormal_immune_serum	0.89787263
110	MP0005381_digestive/alimentary_phenotyp	0.89452077
111	MP0002837_dystrophic_cardiac_calcinosis	0.88720329
112	MP0002736_abnormal_nociception_after	0.87347490
113	MP0008873_increased_physiological_sensi	0.86876010
114	MP0005646_abnormal_pituitary_gland	0.86820153
115	MP0003436_decreased_susceptibility_to	0.85177122
116	MP0004782_abnormal_surfactant_physiolog	0.84529018
117	MP0000516_abnormal_urinary_system	0.84491803
118	MP0005367_renal/urinary_system_phenotyp	0.84491803
119	MP0005171_absent_coat_pigmentation	0.82671050
120	MP0002405_respiratory_system_inflammati	0.81508122
121	MP0003959_abnormal_lean_body	0.79556803
122	MP0003011_delayed_dark_adaptation	0.79028728
123	MP0010094_abnormal_chromosome_stability	0.78433916
124	MP0001765_abnormal_ion_homeostasis	0.78298859
125	MP0002095_abnormal_skin_pigmentation	0.77717364
126	MP0001879_abnormal_lymphatic_vessel	0.77622836
127	MP0001663_abnormal_digestive_system	0.76758420
128	MP0002420_abnormal_adaptive_immunity	0.76347392
129	MP0010329_abnormal_lipoprotein_level	0.76135914
130	MP0003868_abnormal_feces_composition	0.76088809
131	MP0005310_abnormal_salivary_gland	0.75924283
132	MP0005332_abnormal_amino_acid	0.75804195
133	MP0003795_abnormal_bone_structure	0.75565401
134	MP0003077_abnormal_cell_cycle	0.75537085
135	MP0001819_abnormal_immune_cell	0.75475994
136	MP0006082_CNS_inflammation	0.74823729
137	MP0002909_abnormal_adrenal_gland	0.74590687
138	MP0005319_abnormal_enzyme/_coenzyme	0.74469932
139	MP0005376_homeostasis/metabolism_phenot	0.72151961
140	MP0003075_altered_response_to	0.71750544
141	MP0009780_abnormal_chondrocyte_physiolo	0.70179742
142	MP0000639_abnormal_adrenal_gland	0.70079382
143	MP0004133_heterotaxia	0.70009246
144	MP0005390_skeleton_phenotype	0.69945160
145	MP0002160_abnormal_reproductive_system	0.69776946
146	MP0003122_maternal_imprinting	0.69002595
147	MP0000465_gastrointestinal_hemorrhage	0.68886305
148	MP0005389_reproductive_system_phenotype	0.68373783
149	MP0001293_anophthalmia	0.68329109
150	MP0000490_abnormal_crypts_of	0.67810041
151	MP0005395_other_phenotype	0.67067135
152	MP0004215_abnormal_myocardial_fiber	0.66455960
153	MP0003279_aneurysm	0.64031091
154	MP0009763_increased_sensitivity_to	0.63394123

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	5.49995478
2	Mitochondrial inheritance (HP:0001427)	5.18294196
3	Abnormal mitochondria in muscle tissue (HP:0008316)	5.01407137
4	Hepatocellular necrosis (HP:0001404)	4.73624980
5	Hepatic necrosis (HP:0002605)	4.60116274
6	Acute encephalopathy (HP:0006846)	4.55827915
7	Increased CSF lactate (HP:0002490)	4.31952222
8	Progressive macrocephaly (HP:0004481)	4.26139718
9	Renal Fanconi syndrome (HP:0001994)	3.96178261
10	Increased hepatocellular lipid droplets (HP:0006565)	3.93390087
11	Type I transferrin isoform profile (HP:0003642)	3.90830718
12	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.76247324
13	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.76247324
14	Lipid accumulation in hepatocytes (HP:0006561)	3.62566431
15	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	3.55630013
16	Abnormality of cells of the erythroid lineage (HP:0012130)	3.55215772
17	Abnormal protein glycosylation (HP:0012346)	3.46735683
18	Abnormal glycosylation (HP:0012345)	3.46735683
19	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	3.46735683
20	Abnormal protein N-linked glycosylation (HP:0012347)	3.46735683
21	Abnormal number of erythroid precursors (HP:0012131)	3.34730267
22	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	3.29555795
23	3-Methylglutaconic aciduria (HP:0003535)	3.18685844
24	Increased intramyocellular lipid droplets (HP:0012240)	3.18683195
25	Exertional dyspnea (HP:0002875)	3.15211522
26	Lactic acidosis (HP:0003128)	3.04298198
27	Respiratory failure (HP:0002878)	3.02575651
28	Aplastic anemia (HP:0001915)	3.01092785
29	Exercise intolerance (HP:0003546)	2.99535271
30	Increased serum lactate (HP:0002151)	2.97394040
31	Vacuolated lymphocytes (HP:0001922)	2.95169229
32	Abnormality of renal resorption (HP:0011038)	2.90291858
33	Cerebral edema (HP:0002181)	2.87932367
34	Irregular epiphyses (HP:0010582)	2.79203099
35	Increased muscle lipid content (HP:0009058)	2.77292854
36	Congenital, generalized hypertrichosis (HP:0004540)	2.74793254
37	Hypothermia (HP:0002045)	2.70789847
38	Generalized aminoaciduria (HP:0002909)	2.67668076
39	Glycosuria (HP:0003076)	2.67450873
40	Abnormality of urine glucose concentration (HP:0011016)	2.67450873
41	Reduced antithrombin III activity (HP:0001976)	2.65550674
42	Respiratory difficulties (HP:0002880)	2.47610151
43	Leukodystrophy (HP:0002415)	2.45284264
44	Methylmalonic acidemia (HP:0002912)	2.44566049
45	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.43697375
46	Optic disc pallor (HP:0000543)	2.42865851
47	Hyperphosphaturia (HP:0003109)	2.41588125
48	Beaking of vertebral bodies (HP:0004568)	2.39358817
49	Abnormality of placental membranes (HP:0011409)	2.37389788
50	Amniotic constriction ring (HP:0009775)	2.37389788
51	Aplasia/hypoplasia of the uterus (HP:0008684)	2.35298145
52	Oral leukoplakia (HP:0002745)	2.32867622
53	Macrocytic anemia (HP:0001972)	2.27620463
54	Poor head control (HP:0002421)	2.27235565
55	Nausea (HP:0002018)	2.25733614
56	Reticulocytopenia (HP:0001896)	2.23688570
57	X-linked dominant inheritance (HP:0001423)	2.17228236
58	Abnormality of methionine metabolism (HP:0010901)	2.17038884
59	Abnormality of the anterior horn cell (HP:0006802)	2.16832626
60	Degeneration of anterior horn cells (HP:0002398)	2.16832626
61	Microvesicular hepatic steatosis (HP:0001414)	2.16815013
62	Abnormal pupillary function (HP:0007686)	2.15343700
63	Progressive neurologic deterioration (HP:0002344)	2.06557054
64	Flat capital femoral epiphysis (HP:0003370)	2.06385528
65	Hypoplasia of the uterus (HP:0000013)	2.06279125
66	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	2.05767169
67	Purpura (HP:0000979)	2.02230092
68	Sparse eyelashes (HP:0000653)	2.01863899
69	Irregular vertebral endplates (HP:0003301)	2.01293049
70	Neuroendocrine neoplasm (HP:0100634)	2.00834540
71	CNS demyelination (HP:0007305)	2.00799738
72	Pancytopenia (HP:0001876)	1.97386272
73	Abnormal tarsal ossification (HP:0008369)	1.95108528
74	Abnormality of aromatic amino acid family metabolism (HP:0004338)	1.93040204
75	Abnormality of glycolysis (HP:0004366)	1.92770059
76	Increased serum pyruvate (HP:0003542)	1.92770059
77	Blindness (HP:0000618)	1.91431992
78	Pallor (HP:0000980)	1.91111460
79	Hypoglycemic coma (HP:0001325)	1.88652791
80	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.88347737
81	Hyperglycinemia (HP:0002154)	1.88022023
82	Renal tubular dysfunction (HP:0000124)	1.86354927
83	Emotional lability (HP:0000712)	1.85112735
84	Abnormal urine phosphate concentration (HP:0012599)	1.83613740
85	Epiphyseal dysplasia (HP:0002656)	1.82921725
86	Lethargy (HP:0001254)	1.82756768
87	Pheochromocytoma (HP:0002666)	1.78145961
88	Methylmalonic aciduria (HP:0012120)	1.78050833
89	Abnormality of midbrain morphology (HP:0002418)	1.77735151
90	Molar tooth sign on MRI (HP:0002419)	1.77735151
91	Delayed epiphyseal ossification (HP:0002663)	1.76316064
92	Abnormality of magnesium homeostasis (HP:0004921)	1.75267195
93	Symptomatic seizures (HP:0011145)	1.74017559
94	Dysostosis multiplex (HP:0000943)	1.71538575
95	Abnormality of serum amino acid levels (HP:0003112)	1.69541248
96	Parakeratosis (HP:0001036)	1.68875304
97	True hermaphroditism (HP:0010459)	1.67514693
98	Abnormality of the vertebral endplates (HP:0005106)	1.66514666
99	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.65827412
100	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.65732617
101	Abnormality of alanine metabolism (HP:0010916)	1.65732617
102	Hyperalaninemia (HP:0003348)	1.65732617
103	Vomiting (HP:0002013)	1.65489860
104	Menorrhagia (HP:0000132)	1.65476670
105	Cerebral hypomyelination (HP:0006808)	1.65464355
106	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.65365203
107	Dicarboxylic aciduria (HP:0003215)	1.65365203
108	Large for gestational age (HP:0001520)	1.65187445
109	Disproportionate short-trunk short stature (HP:0003521)	1.64164819
110	Rough bone trabeculation (HP:0100670)	1.63176313
111	Abnormality of the femoral head (HP:0003368)	1.63068651
112	Opisthotonus (HP:0002179)	1.62704520
113	Congenital ichthyosiform erythroderma (HP:0007431)	1.62696211
114	Pancreatic cysts (HP:0001737)	1.62170665
115	Hepatosplenomegaly (HP:0001433)	1.61897793
116	Elevated erythrocyte sedimentation rate (HP:0003565)	1.61822103
117	Megaloblastic anemia (HP:0001889)	1.57821607
118	Carpal bone hypoplasia (HP:0001498)	1.57362960
119	Testicular atrophy (HP:0000029)	1.56964592
120	Pancreatic fibrosis (HP:0100732)	1.54441168
121	Renal cortical cysts (HP:0000803)	1.54064483
122	Metaphyseal irregularity (HP:0003025)	1.53968499
123	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.53579982
124	Small epiphyses (HP:0010585)	1.53556829
125	11 pairs of ribs (HP:0000878)	1.53356807
126	Redundant skin (HP:0001582)	1.53182348
127	Hypokinesia (HP:0002375)	1.53013520
128	Medial flaring of the eyebrow (HP:0010747)	1.52697939
129	Petechiae (HP:0000967)	1.52409327
130	Proximal tubulopathy (HP:0000114)	1.52221446
131	IgM deficiency (HP:0002850)	1.50535277
132	Abnormality of the intrinsic pathway (HP:0010989)	1.50242500

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	VRK2	5.72147865
2	NME2	4.27618379
3	STK16	4.19438279
4	EIF2AK3	3.00535437
5	PIM2	2.92767101
6	NME1	2.72059215
7	MAPK15	2.60590549
8	VRK1	2.39806116
9	IRAK3	2.27181384
10	MYLK	2.11715364
11	MAP3K12	2.01887413
12	MST4	1.91890190
13	EIF2AK1	1.87879079
14	BCKDK	1.86608444
15	ARAF	1.84516178
16	TESK1	1.83223917
17	KDR	1.79624372
18	NUAK1	1.78824850
19	MAP4K2	1.75794440
20	BUB1	1.74894139
21	BMPR1B	1.72727296
22	LIMK1	1.70249302
23	TESK2	1.69659266
24	PASK	1.64866209
25	NEK1	1.58345255
26	MUSK	1.56127682
27	IRAK4	1.50257449
28	TRIM28	1.48266691
29	PLK3	1.40707515
30	IRAK1	1.38024227
31	BRAF	1.35442898
32	WNK4	1.33172891
33	TAF1	1.30645376
34	TEC	1.30545526
35	PBK	1.30244630
36	TXK	1.30038618
37	ADRBK2	1.28967571
38	ERN1	1.28609939
39	CDK8	1.24029924
40	PDK2	1.22426166
41	TAOK3	1.20184622
42	PIK3CG	1.16698416
43	DAPK1	1.15652924
44	PLK4	1.09247898
45	STK39	1.07212026
46	MAP3K3	1.05336044
47	MAP2K7	1.04105394
48	CSNK1G1	1.03069832
49	MAPKAPK3	1.02700173
50	DAPK3	1.02536975
51	PAK4	1.00646770
52	TLK1	0.99668449
53	TNIK	0.99337376
54	MAP3K11	0.97798387
55	GRK7	0.97526315
56	CSNK1G2	0.96315707
57	DYRK2	0.95046913
58	MAP2K2	0.93432036
59	ZAK	0.91387945
60	FLT3	0.91359669
61	PRKG2	0.90301366
62	PLK2	0.86556082
63	MAPKAPK5	0.85352510
64	ZAP70	0.85340370
65	NLK	0.85274773
66	TBK1	0.82187404
67	SRPK1	0.80967578
68	SCYL2	0.79335269
69	SIK3	0.78223638
70	BCR	0.77026566
71	CSNK1A1L	0.76291029
72	TSSK6	0.73541926
73	NEK6	0.73377559
74	IRAK2	0.73257801
75	CAMKK2	0.71435070
76	INSRR	0.71422862
77	BTK	0.69902447
78	WNK3	0.69025044
79	CDC7	0.68432371
80	ABL2	0.67479211
81	IKBKE	0.62420421
82	IKBKB	0.62185899
83	LRRK2	0.61921857
84	CDK19	0.60768442
85	GRK1	0.59508576
86	TIE1	0.59470712
87	OBSCN	0.58872083
88	OXSR1	0.58218274
89	CSNK1G3	0.58161412
90	EIF2AK2	0.58073572
91	GRK5	0.57638680
92	STK24	0.56140357
93	BMPR2	0.56041500
94	CAMK2D	0.55163841
95	JAK3	0.54919323
96	STK38L	0.53994887
97	AURKA	0.53839917
98	CSNK2A1	0.53739761
99	ERBB4	0.53340849
100	MAP4K1	0.53301332
101	WEE1	0.52891236
102	LYN	0.52509309
103	HIPK2	0.52508036
104	PRKCI	0.52290416
105	ERBB3	0.50964553
106	BRSK2	0.50780907
107	RPS6KA5	0.50397688
108	ILK	0.50074804
109	PLK1	0.49745935
110	EPHB2	0.49368609
111	PAK1	0.47747489
112	AKT3	0.47555035
113	BRSK1	0.47309965
114	STK4	0.46085113
115	ACVR1B	0.45537179
116	LMTK2	0.44426133
117	TTK	0.44320251
118	CDK3	0.43720947
119	CAMK2G	0.43608757
120	MET	0.43080342
121	KIT	0.41842241
122	SYK	0.41647403
123	PRKCD	0.41113792
124	AURKB	0.40060749
125	PRKCG	0.39505120
126	EPHA2	0.38530438
127	ADRBK1	0.38209949
128	PRKCE	0.38124262
129	PAK3	0.36452555
130	CSNK2A2	0.36053597
131	FER	0.35749071
132	CCNB1	0.35612634
133	PTK2B	0.35567307
134	MAP3K14	0.35504504
135	BLK	0.34233589
136	DYRK3	0.33814483
137	MAP3K5	0.31977712
138	CSNK1A1	0.29320796
139	PINK1	0.28803605

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Protein export_Homo sapiens_hsa03060	5.79801610
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.55695447
3	Ribosome_Homo sapiens_hsa03010	4.12076137
4	Proteasome_Homo sapiens_hsa03050	3.89104772
5	Parkinsons disease_Homo sapiens_hsa05012	3.84907773
6	Alzheimers disease_Homo sapiens_hsa05010	2.76104563
7	Huntingtons disease_Homo sapiens_hsa05016	2.73395389
8	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.69474862
9	RNA polymerase_Homo sapiens_hsa03020	2.65911394
10	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.60270953
11	Sulfur metabolism_Homo sapiens_hsa00920	2.23068658
12	Pyrimidine metabolism_Homo sapiens_hsa00240	1.82857487
13	Folate biosynthesis_Homo sapiens_hsa00790	1.82057363
14	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.64722303
15	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.64190592
16	Other glycan degradation_Homo sapiens_hsa00511	1.59595660
17	Vibrio cholerae infection_Homo sapiens_hsa05110	1.56291536
18	Fatty acid elongation_Homo sapiens_hsa00062	1.50595644
19	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.49853892
20	* Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.47062906
21	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.45808099
22	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.43069513
23	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.27576399
24	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.24709423
25	Propanoate metabolism_Homo sapiens_hsa00640	1.21964209
26	Cardiac muscle contraction_Homo sapiens_hsa04260	1.20998544
27	DNA replication_Homo sapiens_hsa03030	1.12184300
28	* N-Glycan biosynthesis_Homo sapiens_hsa00510	1.11776616
29	One carbon pool by folate_Homo sapiens_hsa00670	1.10803214
30	Basal transcription factors_Homo sapiens_hsa03022	1.09130912
31	Steroid biosynthesis_Homo sapiens_hsa00100	1.08634345
32	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.07782123
33	Purine metabolism_Homo sapiens_hsa00230	1.06165140
34	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.01552101
35	Mismatch repair_Homo sapiens_hsa03430	1.01294088
36	Glutathione metabolism_Homo sapiens_hsa00480	1.01059005
37	Sulfur relay system_Homo sapiens_hsa04122	1.00622446
38	Sphingolipid metabolism_Homo sapiens_hsa00600	0.97876272
39	Homologous recombination_Homo sapiens_hsa03440	0.95649966
40	Nucleotide excision repair_Homo sapiens_hsa03420	0.93978096
41	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.93602416
42	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.93544792
43	Collecting duct acid secretion_Homo sapiens_hsa04966	0.92873775
44	Spliceosome_Homo sapiens_hsa03040	0.91261087
45	* Metabolic pathways_Homo sapiens_hsa01100	0.90896612
46	Linoleic acid metabolism_Homo sapiens_hsa00591	0.88311981
47	Fanconi anemia pathway_Homo sapiens_hsa03460	0.82743382
48	Rheumatoid arthritis_Homo sapiens_hsa05323	0.80465521
49	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.76310130
50	Regulation of autophagy_Homo sapiens_hsa04140	0.75605525
51	Butanoate metabolism_Homo sapiens_hsa00650	0.73527164
52	Lysosome_Homo sapiens_hsa04142	0.72954049
53	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.71868369
54	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.69458651
55	Base excision repair_Homo sapiens_hsa03410	0.68770064
56	Galactose metabolism_Homo sapiens_hsa00052	0.67450210
57	Nitrogen metabolism_Homo sapiens_hsa00910	0.65835087
58	Carbon metabolism_Homo sapiens_hsa01200	0.65092368
59	RNA degradation_Homo sapiens_hsa03018	0.64363721
60	Ether lipid metabolism_Homo sapiens_hsa00565	0.63701558
61	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.63623758
62	Arginine and proline metabolism_Homo sapiens_hsa00330	0.63463153
63	Histidine metabolism_Homo sapiens_hsa00340	0.62434619
64	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.61662331
65	Tryptophan metabolism_Homo sapiens_hsa00380	0.59594134
66	Fatty acid metabolism_Homo sapiens_hsa01212	0.58918783
67	Type I diabetes mellitus_Homo sapiens_hsa04940	0.58683734
68	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.56986357
69	Tyrosine metabolism_Homo sapiens_hsa00350	0.56649483
70	Fatty acid degradation_Homo sapiens_hsa00071	0.56229569
71	Antigen processing and presentation_Homo sapiens_hsa04612	0.55517201
72	Caffeine metabolism_Homo sapiens_hsa00232	0.54339174
73	Mineral absorption_Homo sapiens_hsa04978	0.54317765
74	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.53224303
75	Allograft rejection_Homo sapiens_hsa05330	0.52140700
76	Phagosome_Homo sapiens_hsa04145	0.52019121
77	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.51824751
78	beta-Alanine metabolism_Homo sapiens_hsa00410	0.51018339
79	Asthma_Homo sapiens_hsa05310	0.50457840
80	Peroxisome_Homo sapiens_hsa04146	0.49566231
81	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.49545773
82	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.49539635
83	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.49074598
84	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.48718238
85	Graft-versus-host disease_Homo sapiens_hsa05332	0.48125192
86	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.48075411
87	Primary immunodeficiency_Homo sapiens_hsa05340	0.47878889
88	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.47875375
89	Pentose phosphate pathway_Homo sapiens_hsa00030	0.46270756
90	Phenylalanine metabolism_Homo sapiens_hsa00360	0.46255603
91	Non-homologous end-joining_Homo sapiens_hsa03450	0.45741700
92	Retinol metabolism_Homo sapiens_hsa00830	0.44881782
93	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.44569570
94	Legionellosis_Homo sapiens_hsa05134	0.44484320
95	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.44196855
96	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.43994079
97	Selenocompound metabolism_Homo sapiens_hsa00450	0.43559593
98	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.43271526
99	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.42518320
100	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.38780897
101	Pyruvate metabolism_Homo sapiens_hsa00620	0.38205904
102	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.37261594
103	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.37184523
104	Phototransduction_Homo sapiens_hsa04744	0.36772925
105	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.35119714
106	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.33739126
107	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.31671544
108	RNA transport_Homo sapiens_hsa03013	0.31293556
109	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.30777011
110	Malaria_Homo sapiens_hsa05144	0.30463272
111	Protein digestion and absorption_Homo sapiens_hsa04974	0.28971494
112	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.28193002
113	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.28017905
114	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.27635993
115	Fat digestion and absorption_Homo sapiens_hsa04975	0.27061608
116	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.26220827
117	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.25117659
118	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.24995387
119	Complement and coagulation cascades_Homo sapiens_hsa04610	0.24890278
120	Chemical carcinogenesis_Homo sapiens_hsa05204	0.24534165
121	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.24016929
122	Pancreatic secretion_Homo sapiens_hsa04972	0.23483916
123	Renin-angiotensin system_Homo sapiens_hsa04614	0.23285114
124	p53 signaling pathway_Homo sapiens_hsa04115	0.19852128
125	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.16363523
126	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.16044313

DAD1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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