DAGLA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a diacylglycerol lipase. The encoded enzyme is involved in the biosynthesis of the endocannabinoid 2-arachidonoyl-glycerol. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.07739124
2locomotory exploration behavior (GO:0035641)5.98346156
3synaptic vesicle maturation (GO:0016188)5.96310141
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.57722672
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.53197588
6vocalization behavior (GO:0071625)5.26646840
7synaptic vesicle exocytosis (GO:0016079)5.14153160
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.07718078
9glutamate secretion (GO:0014047)5.04159158
10synaptic vesicle docking involved in exocytosis (GO:0016081)4.98963553
11regulation of glutamate receptor signaling pathway (GO:1900449)4.82961465
12ionotropic glutamate receptor signaling pathway (GO:0035235)4.75074083
13regulation of synaptic vesicle exocytosis (GO:2000300)4.74734887
14regulation of neuronal synaptic plasticity (GO:0048168)4.54789676
15neuronal action potential propagation (GO:0019227)4.47928196
16exploration behavior (GO:0035640)4.47235415
17regulation of long-term neuronal synaptic plasticity (GO:0048169)4.43400798
18regulation of synapse structural plasticity (GO:0051823)4.40836164
19synaptic transmission, glutamatergic (GO:0035249)4.29248477
20protein localization to synapse (GO:0035418)4.28099195
21regulation of synaptic vesicle transport (GO:1902803)4.26165467
22glutamate receptor signaling pathway (GO:0007215)4.19199146
23neurotransmitter secretion (GO:0007269)4.17514479
24dendritic spine morphogenesis (GO:0060997)4.09289140
25long-term memory (GO:0007616)4.03996462
26cellular potassium ion homeostasis (GO:0030007)4.01703701
27layer formation in cerebral cortex (GO:0021819)3.97411544
28regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.94106983
29membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.89751080
30neurotransmitter-gated ion channel clustering (GO:0072578)3.85785550
31sodium ion export (GO:0071436)3.85704801
32positive regulation of synapse maturation (GO:0090129)3.85227331
33neuron-neuron synaptic transmission (GO:0007270)3.82493073
34amino acid import (GO:0043090)3.80820908
35regulation of excitatory postsynaptic membrane potential (GO:0060079)3.79985670
36gamma-aminobutyric acid transport (GO:0015812)3.76912023
37proline transport (GO:0015824)3.74099467
38neuron cell-cell adhesion (GO:0007158)3.71346471
39positive regulation of membrane potential (GO:0045838)3.71196496
40regulation of synaptic plasticity (GO:0048167)3.65394757
41cytoskeletal anchoring at plasma membrane (GO:0007016)3.62733221
42regulation of postsynaptic membrane potential (GO:0060078)3.58861388
43cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.57753363
44activation of protein kinase A activity (GO:0034199)3.54951810
45regulation of dendritic spine morphogenesis (GO:0061001)3.54625011
46neuromuscular process controlling balance (GO:0050885)3.54507831
47positive regulation of neurotransmitter transport (GO:0051590)3.51630473
48cerebellar Purkinje cell differentiation (GO:0021702)3.46378928
49cell communication by electrical coupling (GO:0010644)3.41419332
50chemosensory behavior (GO:0007635)3.34496057
51dendritic spine organization (GO:0097061)3.34482613
52innervation (GO:0060384)3.33832424
53long-term synaptic potentiation (GO:0060291)3.31031647
54dendrite morphogenesis (GO:0048813)3.29661485
55neurotransmitter transport (GO:0006836)3.27928107
56glycine transport (GO:0015816)3.27820855
57synaptic vesicle endocytosis (GO:0048488)3.26761487
58regulation of vesicle fusion (GO:0031338)3.25867033
59regulation of ARF protein signal transduction (GO:0032012)3.25300584
60cell-cell junction maintenance (GO:0045217)3.25005428
61neuromuscular process controlling posture (GO:0050884)3.24728157
62positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.22239869
63regulation of neurotransmitter secretion (GO:0046928)3.21915420
64transmission of nerve impulse (GO:0019226)3.20929214
65G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.20158157
66neuron recognition (GO:0008038)3.19339557
67response to auditory stimulus (GO:0010996)3.19171042
68regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.16343356
69membrane depolarization during action potential (GO:0086010)3.15827737
70protein localization to endosome (GO:0036010)3.15309823
71negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.14268304
72auditory behavior (GO:0031223)3.13945006
73G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.13674886
74regulation of synaptic transmission, glutamatergic (GO:0051966)3.13271205
75positive regulation of synaptic transmission, GABAergic (GO:0032230)3.12994758
76membrane depolarization (GO:0051899)3.10814278
77gamma-aminobutyric acid signaling pathway (GO:0007214)3.07852475
78axonal fasciculation (GO:0007413)3.07233651
79acidic amino acid transport (GO:0015800)3.01935394
80positive regulation of dendritic spine development (GO:0060999)3.01287248
81positive regulation of dendritic spine morphogenesis (GO:0061003)2.99711479
82neuronal ion channel clustering (GO:0045161)2.99688532
83* regulation of neurotransmitter levels (GO:0001505)2.99228354
84cellular sodium ion homeostasis (GO:0006883)2.99203353
85cerebellar granule cell differentiation (GO:0021707)2.96446746
86long term synaptic depression (GO:0060292)2.95769623
87regulation of neurotransmitter transport (GO:0051588)2.95617112
88glycosphingolipid catabolic process (GO:0046479)2.95397357
89positive regulation of neurotransmitter secretion (GO:0001956)2.94861244
90establishment of nucleus localization (GO:0040023)2.94797467
91L-amino acid import (GO:0043092)2.94663477
92regulation of dendritic spine development (GO:0060998)2.93974913
93cerebellar Purkinje cell layer development (GO:0021680)2.93389338
94prepulse inhibition (GO:0060134)2.92660737
95learning (GO:0007612)2.92211006
96positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.91211304
97regulation of synapse maturation (GO:0090128)2.90990382
98neuromuscular process (GO:0050905)2.90915120
99behavioral defense response (GO:0002209)2.90844558
100behavioral fear response (GO:0001662)2.90844558
101regulation of synaptic transmission (GO:0050804)2.90481925
102postsynaptic membrane organization (GO:0001941)2.90245602
103regulation of calcium ion-dependent exocytosis (GO:0017158)2.88392093
104vesicle transport along microtubule (GO:0047496)2.87944495
105positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.87585282
106negative regulation of synaptic transmission, GABAergic (GO:0032229)2.86731503
107regulation of early endosome to late endosome transport (GO:2000641)2.85950216
108membrane hyperpolarization (GO:0060081)2.85199864
109positive regulation of synaptic transmission (GO:0050806)2.84836270
110negative regulation of amino acid transport (GO:0051956)2.84526011
111potassium ion homeostasis (GO:0055075)2.79892035
112L-glutamate transport (GO:0015813)2.79828045
113adenosine receptor signaling pathway (GO:0001973)2.74040341
114regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.70964544
115negative regulation of dendrite morphogenesis (GO:0050774)2.70315573
116cell junction maintenance (GO:0034331)2.65769219
117glycolipid catabolic process (GO:0019377)2.63831693
118positive regulation of heat generation (GO:0031652)2.58705315
119regulation of NFAT protein import into nucleus (GO:0051532)2.58615963
120dicarboxylic acid transport (GO:0006835)2.53692986
121positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.50559232
122regulation of fever generation (GO:0031620)2.46629134
123potassium ion import (GO:0010107)2.46194433
124response to manganese ion (GO:0010042)2.45780817
125ganglioside metabolic process (GO:0001573)2.44090181
126response to acidic pH (GO:0010447)2.44019915
127cell migration in hindbrain (GO:0021535)2.41873604
128cellular response to thyroid hormone stimulus (GO:0097067)2.38909277
129mating behavior (GO:0007617)2.38497020
130positive regulation of dendrite development (GO:1900006)2.38101585
131semaphorin-plexin signaling pathway (GO:0071526)2.36686645
132oligosaccharide catabolic process (GO:0009313)2.36428890

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.94470804
2GBX2_23144817_ChIP-Seq_PC3_Human3.05162215
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.03689898
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.01869664
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.92557915
6DROSHA_22980978_ChIP-Seq_HELA_Human2.82890779
7* RARB_27405468_Chip-Seq_BRAIN_Mouse2.73787787
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.73005931
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.73005931
10REST_21632747_ChIP-Seq_MESCs_Mouse2.67326515
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.64378647
12LXR_22292898_ChIP-Seq_THP-1_Human2.55416366
13* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.54664413
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.54296069
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.53304465
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.45932420
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.42098090
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.32898958
19EZH2_27294783_Chip-Seq_ESCs_Mouse2.27153089
20IKZF1_21737484_ChIP-ChIP_HCT116_Human2.25628888
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.25239562
22MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.24288055
23EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.22360750
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.20740762
25ESR2_21235772_ChIP-Seq_MCF-7_Human2.19648659
26REST_18959480_ChIP-ChIP_MESCs_Mouse2.19325909
27EED_16625203_ChIP-ChIP_MESCs_Mouse2.18119617
28TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.00470832
29NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.99501042
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.93058658
31CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.85996057
32ERG_21242973_ChIP-ChIP_JURKAT_Human1.68515984
33* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.66735886
34ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.64226869
35RARG_19884340_ChIP-ChIP_MEFs_Mouse1.62584609
36NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.61929012
37KDM2B_26808549_Chip-Seq_DND41_Human1.60025732
38GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.56583344
39AR_21572438_ChIP-Seq_LNCaP_Human1.55671928
40SRY_22984422_ChIP-ChIP_TESTIS_Rat1.53805020
41SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.49045464
42RACK7_27058665_Chip-Seq_MCF-7_Human1.47530139
43SMAD4_21799915_ChIP-Seq_A2780_Human1.43403776
44KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.39809158
45* SMC4_20622854_ChIP-Seq_HELA_Human1.38244920
46* KDM2B_26808549_Chip-Seq_K562_Human1.38191729
47* ELK3_25401928_ChIP-Seq_HUVEC_Human1.37523592
48* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.36307222
49ZNF274_21170338_ChIP-Seq_K562_Hela1.35290111
50CTBP2_25329375_ChIP-Seq_LNCAP_Human1.35153275
51NR3C1_23031785_ChIP-Seq_PC12_Mouse1.32872575
52RING1B_27294783_Chip-Seq_ESCs_Mouse1.32647404
53* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.32134086
54RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.31464564
55WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.30831160
56NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.30712652
57* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.30152985
58* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.28806021
59AR_19668381_ChIP-Seq_PC3_Human1.27755287
60CTBP1_25329375_ChIP-Seq_LNCAP_Human1.27267964
61SOX2_21211035_ChIP-Seq_LN229_Gbm1.26596005
62EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.25475336
63PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.24030135
64ZFP281_18757296_ChIP-ChIP_E14_Mouse1.23961097
65PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.22503247
66SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.22146715
67TCF7_22412390_ChIP-Seq_EML_Mouse1.21751297
68P68_20966046_ChIP-Seq_HELA_Human1.20489902
69* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.19627747
70SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17441033
71VDR_21846776_ChIP-Seq_THP-1_Human1.16972163
72GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16880435
73CREB1_26743006_Chip-Seq_LNCaP_Human1.16083692
74* KDM2B_26808549_Chip-Seq_JURKAT_Human1.14947890
75RING1B_27294783_Chip-Seq_NPCs_Mouse1.11829508
76* STAT3_23295773_ChIP-Seq_U87_Human1.11715858
77RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.11434873
78ZNF263_19887448_ChIP-Seq_K562_Human1.11359813
79VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.11158064
80TET1_21451524_ChIP-Seq_MESCs_Mouse1.10653376
81THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.10121560
82AR_25329375_ChIP-Seq_VCAP_Human1.09944599
83* TP53_20018659_ChIP-ChIP_R1E_Mouse1.08863482
84SMAD_19615063_ChIP-ChIP_OVARY_Human1.08738558
85SMAD3_21741376_ChIP-Seq_EPCs_Human1.08226161
86NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.07862839
87NFIB_24661679_ChIP-Seq_LUNG_Mouse1.07656155
88ESR1_21235772_ChIP-Seq_MCF-7_Human1.07622897
89CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.05446936
90CTCF_27219007_Chip-Seq_ERYTHROID_Human1.04754261
91YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04615970
92AHR_22903824_ChIP-Seq_MCF-7_Human1.04608852
93TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.04571157
94SA1_27219007_Chip-Seq_ERYTHROID_Human1.03441647
95ARNT_22903824_ChIP-Seq_MCF-7_Human1.03211660
96PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.01857179
97TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01268225
98RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.00574322
99CDX2_19796622_ChIP-Seq_MESCs_Mouse1.00367478
100EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.99985640
101P300_27058665_Chip-Seq_ZR-75-30cells_Human0.99726941
102TP53_16413492_ChIP-PET_HCT116_Human0.98250345
103PIAS1_25552417_ChIP-Seq_VCAP_Human0.97970432
104SMAD3_21741376_ChIP-Seq_HESCs_Human0.97779104
105P300_19829295_ChIP-Seq_ESCs_Human0.97706254
106ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.97650268
107* OCT4_19829295_ChIP-Seq_ESCs_Human0.97282842
108GATA1_19941827_ChIP-Seq_MEL_Mouse0.97277414
109TOP2B_26459242_ChIP-Seq_MCF-7_Human0.96775932
110ZFP281_27345836_Chip-Seq_ESCs_Mouse0.96406891
111TET1_21490601_ChIP-Seq_MESCs_Mouse0.96333774
112P53_22127205_ChIP-Seq_FIBROBLAST_Human0.96264212
113SMAD3_21741376_ChIP-Seq_ESCs_Human0.95605585
114SMAD4_21741376_ChIP-Seq_HESCs_Human0.95560324
115TCF4_23295773_ChIP-Seq_U87_Human0.95248774
116RXR_22108803_ChIP-Seq_LS180_Human0.94384459
117SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.94159038
118OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93382457
119GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.92662845
120CTCF_27219007_Chip-Seq_Bcells_Human0.92561660
121JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.92545346
122NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92488617
123* TP53_23651856_ChIP-Seq_MEFs_Mouse0.92065370
124KDM2B_26808549_Chip-Seq_SUP-B15_Human0.91747802
125* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.91474804
126MITF_21258399_ChIP-Seq_MELANOMA_Human0.91377290
127ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.90958876
128SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90882984
129MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.88886975
130SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.88721830
131CBX2_27304074_Chip-Seq_ESCs_Mouse0.86546110
132SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.85935697
133Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.85680814
134PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.85613952
135CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.85585901
136OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.85491217
137* SA1_27219007_Chip-Seq_Bcells_Human0.84644283
138SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.84582830
139* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.84059635
140ZFP57_27257070_Chip-Seq_ESCs_Mouse0.83841595
141* FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.83840022
142STAT6_21828071_ChIP-Seq_BEAS2B_Human0.83835986
143* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.83689709
144CTNNB1_20460455_ChIP-Seq_HCT116_Human0.83400376
145TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.82594412
146KLF4_19829295_ChIP-Seq_ESCs_Human0.82406881

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.41897272
2* MP0003635_abnormal_synaptic_transmissio4.26150084
3MP0003880_abnormal_central_pattern4.21209827
4MP0004270_analgesia3.79783110
5MP0005058_abnormal_lysosome_morphology3.64698704
6MP0002063_abnormal_learning/memory/cond3.37994656
7MP0009745_abnormal_behavioral_response3.34067621
8MP0002064_seizures3.12828036
9MP0009046_muscle_twitch3.06557662
10MP0003303_peritoneal_inflammation2.76210092
11MP0002572_abnormal_emotion/affect_behav2.75880295
12MP0001968_abnormal_touch/_nociception2.74927366
13MP0002734_abnormal_mechanical_nocicepti2.52571721
14MP0002822_catalepsy2.52234392
15MP0005423_abnormal_somatic_nervous2.51007707
16MP0009780_abnormal_chondrocyte_physiolo2.49384628
17MP0002272_abnormal_nervous_system2.49242879
18MP0001486_abnormal_startle_reflex2.46470651
19MP0009840_abnormal_foam_cell2.26818651
20MP0001501_abnormal_sleep_pattern2.25632380
21MP0002736_abnormal_nociception_after2.08639590
22MP0002909_abnormal_adrenal_gland2.07956865
23MP0002735_abnormal_chemical_nociception2.07852988
24MP0004858_abnormal_nervous_system2.07605088
25MP0008569_lethality_at_weaning2.03712483
26MP0001440_abnormal_grooming_behavior1.99084558
27MP0002733_abnormal_thermal_nociception1.89966178
28MP0001970_abnormal_pain_threshold1.85233846
29MP0002067_abnormal_sensory_capabilities1.84584444
30MP0003329_amyloid_beta_deposits1.82396049
31* MP0004811_abnormal_neuron_physiology1.78043356
32MP0003879_abnormal_hair_cell1.72417290
33MP0002184_abnormal_innervation1.72292838
34MP0002557_abnormal_social/conspecific_i1.71543018
35MP0003123_paternal_imprinting1.60881971
36MP0005386_behavior/neurological_phenoty1.59438521
37MP0004924_abnormal_behavior1.59438521
38MP0000778_abnormal_nervous_system1.58697098
39MP0000955_abnormal_spinal_cord1.55557127
40MP0005646_abnormal_pituitary_gland1.55105788
41MP0003283_abnormal_digestive_organ1.53523407
42MP0003633_abnormal_nervous_system1.43582464
43MP0003705_abnormal_hypodermis_morpholog1.42571845
44MP0004885_abnormal_endolymph1.41780730
45MP0005451_abnormal_body_composition1.41602090
46MP0000569_abnormal_digit_pigmentation1.39628321
47MP0002066_abnormal_motor_capabilities/c1.37996860
48* MP0002882_abnormal_neuron_morphology1.35781898
49MP0000343_altered_response_to1.32598284
50MP0006082_CNS_inflammation1.29007122
51MP0003191_abnormal_cellular_cholesterol1.28344370
52MP0008961_abnormal_basal_metabolism1.27730677
53MP0003787_abnormal_imprinting1.27400040
54MP0001849_ear_inflammation1.26538322
55MP0002139_abnormal_hepatobiliary_system1.26162498
56MP0000013_abnormal_adipose_tissue1.22281951
57MP0001984_abnormal_olfaction1.20911355
58MP0001502_abnormal_circadian_rhythm1.20237275
59MP0004145_abnormal_muscle_electrophysio1.19852641
60MP0005166_decreased_susceptibility_to1.19712087
61MP0003075_altered_response_to1.19252820
62MP0005645_abnormal_hypothalamus_physiol1.17764954
63MP0003631_nervous_system_phenotype1.16408401
64MP0009278_abnormal_bone_marrow1.13952797
65MP0000751_myopathy1.11851202
66MP0002152_abnormal_brain_morphology1.07766513
67MP0002998_abnormal_bone_remodeling1.03541613
68MP0006276_abnormal_autonomic_nervous1.01291032
69MP0010386_abnormal_urinary_bladder1.00069284
70MP0003122_maternal_imprinting0.95929703
71MP0002069_abnormal_eating/drinking_beha0.95776688
72MP0003453_abnormal_keratinocyte_physiol0.95747946
73MP0004142_abnormal_muscle_tone0.94281473
74MP0003690_abnormal_glial_cell0.93434007
75MP0003172_abnormal_lysosome_physiology0.91452561
76MP0005257_abnormal_intraocular_pressure0.91425065
77MP0001177_atelectasis0.90742152
78MP0005535_abnormal_body_temperature0.90403187
79MP0004233_abnormal_muscle_weight0.90377113
80MP0008872_abnormal_physiological_respon0.90114704
81MP0003634_abnormal_glial_cell0.89399065
82MP0001529_abnormal_vocalization0.88102981
83MP0002229_neurodegeneration0.87752838
84MP0005076_abnormal_cell_differentiation0.86638403
85MP0004510_myositis0.85440600
86MP0003436_decreased_susceptibility_to0.84742589
87MP0004085_abnormal_heartbeat0.84670873
88MP0002148_abnormal_hypersensitivity_rea0.84380640
89MP0005409_darkened_coat_color0.83620467
90MP0008874_decreased_physiological_sensi0.83304083
91MP0001905_abnormal_dopamine_level0.82000547
92MP0003632_abnormal_nervous_system0.81401649
93MP0003091_abnormal_cell_migration0.80706831
94MP0002837_dystrophic_cardiac_calcinosis0.80468528
95MP0002090_abnormal_vision0.79602855
96MP0004043_abnormal_pH_regulation0.78971579
97MP0000604_amyloidosis0.77824035
98MP0008260_abnormal_autophagy0.77767790
99MP0003300_gastrointestinal_ulcer0.75097310
100MP0005623_abnormal_meninges_morphology0.74062881
101MP0001299_abnormal_eye_distance/0.73408973
102MP0008004_abnormal_stomach_pH0.72130810
103MP0003045_fibrosis0.72083532
104MP0000920_abnormal_myelination0.71780402
105MP0004215_abnormal_myocardial_fiber0.68741456
106MP0005167_abnormal_blood-brain_barrier0.68547843
107MP0005595_abnormal_vascular_smooth0.67362153
108MP0003137_abnormal_impulse_conducting0.66651365
109MP0001963_abnormal_hearing_physiology0.66251115
110MP0001664_abnormal_digestion0.66103356
111MP0002896_abnormal_bone_mineralization0.65820162
112MP0003183_abnormal_peptide_metabolism0.65179850
113MP0004742_abnormal_vestibular_system0.65104634
114MP0005551_abnormal_eye_electrophysiolog0.63074955
115MP0005394_taste/olfaction_phenotype0.62934006
116MP0005499_abnormal_olfactory_system0.62934006
117MP0002234_abnormal_pharynx_morphology0.61760701
118MP0001188_hyperpigmentation0.61383663
119MP0002332_abnormal_exercise_endurance0.60870077
120MP0004484_altered_response_of0.59748608
121MP0004130_abnormal_muscle_cell0.59449743
122MP0010234_abnormal_vibrissa_follicle0.59294668
123MP0000631_abnormal_neuroendocrine_gland0.58692394
124MP0001348_abnormal_lacrimal_gland0.58117805
125MP0002419_abnormal_innate_immunity0.57955457
126MP0000747_muscle_weakness0.57099674
127MP0002752_abnormal_somatic_nervous0.56922119
128MP0001533_abnormal_skeleton_physiology0.56232149
129MP0002089_abnormal_postnatal_growth/wei0.55702762
130MP0000681_abnormal_thyroid_gland0.55070966
131MP0001485_abnormal_pinna_reflex0.54930833

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.16120052
2Myokymia (HP:0002411)6.79717874
3Focal seizures (HP:0007359)5.56302525
4Visual hallucinations (HP:0002367)5.45446870
5Abnormality of glycolipid metabolism (HP:0010969)4.85593419
6Abnormality of liposaccharide metabolism (HP:0010968)4.85593419
7Abnormality of glycosphingolipid metabolism (HP:0004343)4.85593419
8Action tremor (HP:0002345)4.57208450
9Epileptic encephalopathy (HP:0200134)4.47754186
10Progressive cerebellar ataxia (HP:0002073)4.47295469
11Atonic seizures (HP:0010819)4.12715937
12Increased cerebral lipofuscin (HP:0011813)4.01295644
13Febrile seizures (HP:0002373)3.89494246
14Absence seizures (HP:0002121)3.79076688
15Generalized tonic-clonic seizures (HP:0002069)3.66856790
16Dysostosis multiplex (HP:0000943)3.66705682
17Diminished motivation (HP:0000745)3.62165138
18Supranuclear gaze palsy (HP:0000605)3.51505446
19Dialeptic seizures (HP:0011146)3.49881377
20Nuclear cataract (HP:0100018)3.47019610
21Vacuolated lymphocytes (HP:0001922)3.40469137
22Depression (HP:0000716)3.35650873
23Gaze-evoked nystagmus (HP:0000640)3.34336843
24Poor eye contact (HP:0000817)3.29644666
25Genetic anticipation (HP:0003743)3.27251687
26Loss of speech (HP:0002371)3.27194127
27Broad-based gait (HP:0002136)3.25102497
28Increased neuronal autofluorescent lipopigment (HP:0002074)3.24890189
29Impaired vibration sensation in the lower limbs (HP:0002166)3.23615666
30Ankle clonus (HP:0011448)3.17159213
31Dysdiadochokinesis (HP:0002075)3.13901925
32Abnormality of the lower motor neuron (HP:0002366)3.10612392
33Dysmetria (HP:0001310)3.06732214
34Disinhibition (HP:0000734)3.04831823
35Postural instability (HP:0002172)3.03168233
36Impaired smooth pursuit (HP:0007772)3.02299400
37Axonal loss (HP:0003447)3.01898414
38Abnormal social behavior (HP:0012433)3.01329377
39Impaired social interactions (HP:0000735)3.01329377
40Abnormality of mucopolysaccharide metabolism (HP:0011020)3.00234465
41Abnormality of polysaccharide metabolism (HP:0011012)3.00234465
42Abnormality of glycosaminoglycan metabolism (HP:0004371)3.00234465
43Urinary glycosaminoglycan excretion (HP:0003541)2.93731820
44Mucopolysacchariduria (HP:0008155)2.93731820
45Truncal ataxia (HP:0002078)2.92838996
46Papilledema (HP:0001085)2.92309713
47Anxiety (HP:0000739)2.91916066
48Urinary bladder sphincter dysfunction (HP:0002839)2.91128430
49Hemiplegia (HP:0002301)2.87157726
50Mutism (HP:0002300)2.86578019
51Amblyopia (HP:0000646)2.71233613
52Hyperacusis (HP:0010780)2.63610692
53Abnormal eating behavior (HP:0100738)2.63486947
54Hemiparesis (HP:0001269)2.63456728
55Dysmetric saccades (HP:0000641)2.59806193
56Epileptiform EEG discharges (HP:0011182)2.59477228
57Dementia (HP:0000726)2.58592252
58Abnormality of ocular smooth pursuit (HP:0000617)2.56922766
59Hyperventilation (HP:0002883)2.56316170
60Ventricular fibrillation (HP:0001663)2.56248016
61Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.55742285
62Scanning speech (HP:0002168)2.55251639
63Torticollis (HP:0000473)2.54165592
64Intention tremor (HP:0002080)2.53012424
65Stereotypic behavior (HP:0000733)2.50106120
66Distal upper limb amyotrophy (HP:0007149)2.48518154
67Upper limb amyotrophy (HP:0009129)2.48518154
68Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.46215255
69EEG with generalized epileptiform discharges (HP:0011198)2.45577276
70Systemic lupus erythematosus (HP:0002725)2.44856288
71Diplopia (HP:0000651)2.43814571
72Abnormality of binocular vision (HP:0011514)2.43814571
73Focal dystonia (HP:0004373)2.42434828
74Drooling (HP:0002307)2.40661661
75Excessive salivation (HP:0003781)2.40661661
76Bundle branch block (HP:0011710)2.39282926
77Megalencephaly (HP:0001355)2.37654225
78Bradykinesia (HP:0002067)2.37429504
79Urinary urgency (HP:0000012)2.36131020
80Cerebral inclusion bodies (HP:0100314)2.35702908
81Hypsarrhythmia (HP:0002521)2.35429903
82Upper motor neuron abnormality (HP:0002127)2.33393157
83Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.32940537
84Annular pancreas (HP:0001734)2.32838996
85Spastic gait (HP:0002064)2.31171949
86Akinesia (HP:0002304)2.28667983
87Neurofibrillary tangles (HP:0002185)2.28383771
88Agitation (HP:0000713)2.26903748
89Status epilepticus (HP:0002133)2.26814253
90Peripheral hypomyelination (HP:0007182)2.24341360
91Pointed chin (HP:0000307)2.23164786
92Hand muscle atrophy (HP:0009130)2.20987519
93Impaired vibratory sensation (HP:0002495)2.17402987
94Personality changes (HP:0000751)2.14954252
95Cerebral aneurysm (HP:0004944)2.08966838
96Turricephaly (HP:0000262)2.08076882
97Insomnia (HP:0100785)2.08041778
98Insidious onset (HP:0003587)2.05959328
99Termporal pattern (HP:0011008)2.05959328
100Retinal atrophy (HP:0001105)2.04407545
101Obstructive sleep apnea (HP:0002870)2.04000140
102Craniofacial dystonia (HP:0012179)2.03429490
103Absent speech (HP:0001344)1.98985093
104Lower limb muscle weakness (HP:0007340)1.97546692
105Tetraplegia (HP:0002445)1.96960260
106Rapidly progressive (HP:0003678)1.95114839
107Lower limb asymmetry (HP:0100559)1.94298326
108Polyphagia (HP:0002591)1.93759631
109Hyperparathyroidism (HP:0000843)1.93069272
110Amyloidosis (HP:0011034)1.92476796
111Urinary incontinence (HP:0000020)1.91245008
112Neuronal loss in central nervous system (HP:0002529)1.91164763
113Gait ataxia (HP:0002066)1.90006461
114Spastic tetraparesis (HP:0001285)1.89390907
115Ankyloglossia (HP:0010296)1.88723582
116Abnormal EKG (HP:0003115)1.88457624
117Increased circulating renin level (HP:0000848)1.86551743
118Abnormality of macrophages (HP:0004311)1.86537686
119Generalized myoclonic seizures (HP:0002123)1.86171565
120Lower limb amyotrophy (HP:0007210)1.86083508
121Fetal akinesia sequence (HP:0001989)1.85418795
122Decreased circulating renin level (HP:0003351)1.81878005
123Incomplete penetrance (HP:0003829)1.81252995
124Hypoventilation (HP:0002791)1.79970851
125J-shaped sella turcica (HP:0002680)1.79799166
126Limb ataxia (HP:0002070)1.79400746
127Abnormality of saccadic eye movements (HP:0000570)1.78584581
128Clonus (HP:0002169)1.78557362
129Memory impairment (HP:0002354)1.77930457
130Thin bony cortex (HP:0002753)1.77637767
131Hammertoe (HP:0001765)1.77141450
132Delusions (HP:0000746)1.76723917
133Progressive inability to walk (HP:0002505)1.76447084
134Apathy (HP:0000741)1.75533133
135Rigidity (HP:0002063)1.75408868
136Postural tremor (HP:0002174)1.75360625
137Spinal canal stenosis (HP:0003416)1.74158441
138Pathologic fracture (HP:0002756)1.73216945
139Abnormality of the periventricular white matter (HP:0002518)1.71298382
140Agnosia (HP:0010524)1.70657791
141Pheochromocytoma (HP:0002666)1.70572994
142Psychosis (HP:0000709)1.70567503
143Prolonged QT interval (HP:0001657)1.69876473
144Resting tremor (HP:0002322)1.69780272
145Athetosis (HP:0002305)1.67547120
146Abnormality of the corticospinal tract (HP:0002492)1.66728967
147Macroorchidism (HP:0000053)1.66271102
148Myocardial infarction (HP:0001658)1.65624469
149Inappropriate behavior (HP:0000719)1.62778928

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.71519986
2EPHA44.64078466
3MAP3K93.79960372
4IRAK33.15080213
5PRKD32.76619826
6DAPK22.66043530
7MINK12.55740423
8MAP3K42.54665945
9MARK12.46130283
10PAK62.41013707
11KSR22.28887108
12CAMKK12.22011966
13NTRK22.10705940
14MAP3K112.00201006
15NTRK11.95623011
16MAP2K71.91838484
17RIPK41.83851517
18KSR11.69941049
19TAOK21.61680668
20SIK11.61091877
21CDK51.57583196
22DAPK11.57384873
23MAP2K41.56299333
24CAMK1D1.54825406
25STK381.54227706
26CAMKK21.43494610
27PRPF4B1.42027442
28TESK11.40994807
29MAP3K21.39845550
30TYRO31.30929671
31SIK21.28152870
32PRKCG1.20893630
33TNIK1.19924995
34PLK21.19154556
35MAP3K131.19131454
36ARAF1.18641103
37FES1.18628038
38GRK51.16904853
39UHMK11.15402927
40RIPK11.13836098
41CAMK11.12341708
42TAOK11.11387492
43MAP3K121.11241261
44LIMK11.10660201
45NME21.07790283
46PRKCH1.05414984
47FGR1.01764302
48MAPK131.00216249
49MOS0.99132941
50PTK2B0.98677990
51RET0.96358754
52CDK190.94392082
53GRK70.93690593
54IRAK20.92782340
55PHKG10.92349731
56PHKG20.92349731
57STK110.91041720
58CAMK2A0.90689410
59CAMK1G0.89541227
60MARK20.88831256
61CDK180.87814560
62CDK150.86641059
63CAMK2B0.86475266
64PAK30.85238265
65PNCK0.83714546
66CDC42BPA0.83648820
67PIM20.82512338
68SGK2230.81012645
69SGK4940.81012645
70MATK0.79817752
71CDK140.79615180
72ALK0.76569821
73LATS20.75736690
74ABL20.75630681
75MAP3K10.75608144
76PDK10.74300987
77CDK11A0.74232989
78SGK30.74041188
79PRKG20.73614638
80RAF10.73271659
81SGK10.71377224
82DMPK0.71349042
83TRIB30.71253717
84CASK0.71098640
85PDPK10.71023083
86LMTK20.70610588
87SGK20.70523452
88MAP3K70.65484735
89BRAF0.65332082
90DYRK1A0.63535089
91PDGFRA0.62472166
92PINK10.59469121
93CAMK40.59227437
94FER0.58909207
95MAP3K30.56271252
96SMG10.56117495
97SCYL20.55125638
98DAPK30.54646194
99RPS6KA30.54219882
100INSRR0.53908068
101BRSK10.52630844
102MAPK120.52409669
103MAP2K10.51467650
104ERN10.50573389
105WNK10.50220460
106PRKCZ0.49832066
107CSNK1G20.49313452
108TTN0.49225149
109FYN0.49155322
110DDR20.49093415
111NEK60.46589510
112CAMK2D0.46269175
113MAP2K60.46121032
114BMPR20.45857602
115PRKCE0.44910651
116PKN10.44209083
117MAPK100.43987587
118PTK20.42997665
119FGFR40.42654528
120DYRK1B0.42122588
121PAK40.41114394
122EPHB20.40610497
123WNK30.39729144
124RPS6KA20.39010202
125CAMK2G0.38474412
126TBK10.38176462
127PRKD20.37837118
128NME10.37601225
129TNK20.37524917
130BLK0.36621793
131RPS6KC10.36543016
132RPS6KL10.36543016
133ICK0.36270431

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.24670130
2Synaptic vesicle cycle_Homo sapiens_hsa047212.92188723
3Circadian entrainment_Homo sapiens_hsa047132.71262638
4Long-term potentiation_Homo sapiens_hsa047202.69179972
5Olfactory transduction_Homo sapiens_hsa047402.56119285
6Glutamatergic synapse_Homo sapiens_hsa047242.51794739
7Amphetamine addiction_Homo sapiens_hsa050312.46013215
8GABAergic synapse_Homo sapiens_hsa047272.45602763
9Other glycan degradation_Homo sapiens_hsa005112.44646464
10* Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.36542296
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.28857354
12Morphine addiction_Homo sapiens_hsa050322.27725457
13Insulin secretion_Homo sapiens_hsa049112.27373625
14Salivary secretion_Homo sapiens_hsa049702.14879351
15Lysosome_Homo sapiens_hsa041422.09445853
16Dopaminergic synapse_Homo sapiens_hsa047282.05220884
17Cholinergic synapse_Homo sapiens_hsa047251.91112899
18Gastric acid secretion_Homo sapiens_hsa049711.90805746
19Glycosaminoglycan degradation_Homo sapiens_hsa005311.89871894
20* Aldosterone synthesis and secretion_Homo sapiens_hsa049251.88388527
21Cocaine addiction_Homo sapiens_hsa050301.68147720
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.67347948
23Oxytocin signaling pathway_Homo sapiens_hsa049211.64202532
24Long-term depression_Homo sapiens_hsa047301.63421411
25Taste transduction_Homo sapiens_hsa047421.60387040
26Calcium signaling pathway_Homo sapiens_hsa040201.55906206
27Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.55717607
28Renin secretion_Homo sapiens_hsa049241.54927506
29GnRH signaling pathway_Homo sapiens_hsa049121.48611618
30Type II diabetes mellitus_Homo sapiens_hsa049301.48205482
31Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.45498421
32Serotonergic synapse_Homo sapiens_hsa047261.41129249
33Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.40045730
34cAMP signaling pathway_Homo sapiens_hsa040241.31869948
35Gap junction_Homo sapiens_hsa045401.27486350
36Estrogen signaling pathway_Homo sapiens_hsa049151.25729206
37Glioma_Homo sapiens_hsa052141.23679928
38Phosphatidylinositol signaling system_Homo sapiens_hsa040701.23524533
39Pancreatic secretion_Homo sapiens_hsa049721.23316351
40Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.22253000
41Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.19158546
42Salmonella infection_Homo sapiens_hsa051321.17389781
43Vitamin B6 metabolism_Homo sapiens_hsa007501.16011204
44Nitrogen metabolism_Homo sapiens_hsa009101.14311440
45Toll-like receptor signaling pathway_Homo sapiens_hsa046201.12397587
46cGMP-PKG signaling pathway_Homo sapiens_hsa040221.12034231
47Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.11447522
48Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.08525722
49Rheumatoid arthritis_Homo sapiens_hsa053231.07915101
50Osteoclast differentiation_Homo sapiens_hsa043801.07734838
51Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.07714835
52Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.07600399
53Melanogenesis_Homo sapiens_hsa049161.03621127
54Axon guidance_Homo sapiens_hsa043601.01944007
55ErbB signaling pathway_Homo sapiens_hsa040121.01298404
56Collecting duct acid secretion_Homo sapiens_hsa049660.99960485
57Vascular smooth muscle contraction_Homo sapiens_hsa042700.97578545
58Tuberculosis_Homo sapiens_hsa051520.97035896
59Thyroid hormone synthesis_Homo sapiens_hsa049180.91998941
60Carbohydrate digestion and absorption_Homo sapiens_hsa049730.91710658
61Phospholipase D signaling pathway_Homo sapiens_hsa040720.91698685
62Dorso-ventral axis formation_Homo sapiens_hsa043200.89603678
63Pertussis_Homo sapiens_hsa051330.89110997
64Dilated cardiomyopathy_Homo sapiens_hsa054140.86379523
65Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.84040223
66Vibrio cholerae infection_Homo sapiens_hsa051100.83352585
67TNF signaling pathway_Homo sapiens_hsa046680.81725561
68Phagosome_Homo sapiens_hsa041450.81310989
69Amoebiasis_Homo sapiens_hsa051460.77257000
70Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.76491083
71Choline metabolism in cancer_Homo sapiens_hsa052310.76109878
72Neurotrophin signaling pathway_Homo sapiens_hsa047220.75889089
73Oocyte meiosis_Homo sapiens_hsa041140.74718575
74Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.74432748
75Bladder cancer_Homo sapiens_hsa052190.73021197
76VEGF signaling pathway_Homo sapiens_hsa043700.72120048
77Cardiac muscle contraction_Homo sapiens_hsa042600.71571213
78Glucagon signaling pathway_Homo sapiens_hsa049220.71089751
79Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.69062792
80Notch signaling pathway_Homo sapiens_hsa043300.68857073
81Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68696881
82MAPK signaling pathway_Homo sapiens_hsa040100.68465668
83mTOR signaling pathway_Homo sapiens_hsa041500.67815665
84Rap1 signaling pathway_Homo sapiens_hsa040150.61686926
85Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.60446953
86Mineral absorption_Homo sapiens_hsa049780.60370702
87Sphingolipid metabolism_Homo sapiens_hsa006000.60228216
88Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.58352377
89Inositol phosphate metabolism_Homo sapiens_hsa005620.57712229
90Bile secretion_Homo sapiens_hsa049760.56115890
91Circadian rhythm_Homo sapiens_hsa047100.55994920
92Ras signaling pathway_Homo sapiens_hsa040140.55941963
93Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55858967
94Adipocytokine signaling pathway_Homo sapiens_hsa049200.55625187
95AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.55290359
96Endocytosis_Homo sapiens_hsa041440.55101124
97Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54021125
98Non-small cell lung cancer_Homo sapiens_hsa052230.52844052
99Prion diseases_Homo sapiens_hsa050200.52839995
100Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.52044426
101Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.51361355
102Sphingolipid signaling pathway_Homo sapiens_hsa040710.51139696
103Fatty acid biosynthesis_Homo sapiens_hsa000610.50800181
104Leishmaniasis_Homo sapiens_hsa051400.50758774
105Type I diabetes mellitus_Homo sapiens_hsa049400.50419874
106Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50326585
107Endometrial cancer_Homo sapiens_hsa052130.48792154
108Malaria_Homo sapiens_hsa051440.48038675
109Insulin signaling pathway_Homo sapiens_hsa049100.47336689
110Fructose and mannose metabolism_Homo sapiens_hsa000510.46207785
111Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.44572317
112Renal cell carcinoma_Homo sapiens_hsa052110.41667748
113Alcoholism_Homo sapiens_hsa050340.40299513
114Wnt signaling pathway_Homo sapiens_hsa043100.40124966
115Phototransduction_Homo sapiens_hsa047440.39406628
116Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.37444449
117Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.36594660
118Chemokine signaling pathway_Homo sapiens_hsa040620.36345231
119Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.35586075
120Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.34645400
121African trypanosomiasis_Homo sapiens_hsa051430.31320730
122Ovarian steroidogenesis_Homo sapiens_hsa049130.31081532
123Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.29697387
124Prolactin signaling pathway_Homo sapiens_hsa049170.27405625
125Platelet activation_Homo sapiens_hsa046110.27084055
126Regulation of actin cytoskeleton_Homo sapiens_hsa048100.26662064
127Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.26305219
128Colorectal cancer_Homo sapiens_hsa052100.25193725

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