DAGLB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1microglial cell activation (GO:0001774)5.75767391
2sphingosine metabolic process (GO:0006670)5.51917083
3modulation by symbiont of host defense response (GO:0052031)5.21197895
4modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.21197895
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.21197895
6positive regulation by organism of defense response of other organism involved in symbiotic interact5.21197895
7modulation by symbiont of host immune response (GO:0052553)5.21197895
8positive regulation by symbiont of host defense response (GO:0052509)5.21197895
9regulation of interferon-beta biosynthetic process (GO:0045357)5.16063892
10cellular extravasation (GO:0045123)5.06677183
11diol metabolic process (GO:0034311)5.06129054
12antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.72086738
13sphingoid metabolic process (GO:0046519)4.71841303
14macrophage activation involved in immune response (GO:0002281)4.64733541
15respiratory burst (GO:0045730)4.59486216
16positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.43708786
17regulation of B cell receptor signaling pathway (GO:0050855)4.39754022
18lipopolysaccharide metabolic process (GO:0008653)4.17832890
19macrophage activation (GO:0042116)4.10241512
20chaperone mediated protein folding requiring cofactor (GO:0051085)4.08470624
21positive regulation of cellular amide metabolic process (GO:0034250)3.99910099
22lipopolysaccharide biosynthetic process (GO:0009103)3.98914656
23positive regulation of chemokine secretion (GO:0090197)3.92350650
24myeloid cell activation involved in immune response (GO:0002275)3.87755146
25G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.85734909
26regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.76377934
27mast cell degranulation (GO:0043303)3.68447336
28mast cell activation involved in immune response (GO:0002279)3.68447336
29neutrophil activation involved in immune response (GO:0002283)3.67185510
30positive regulation of antigen processing and presentation (GO:0002579)3.57963964
31response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.56592518
32response to host immune response (GO:0052572)3.56592518
33mast cell activation (GO:0045576)3.49861463
34glycosphingolipid catabolic process (GO:0046479)3.43854383
35positive regulation of gamma-delta T cell activation (GO:0046645)3.42543761
36negative regulation of interleukin-12 production (GO:0032695)3.38667179
37DNA methylation involved in gamete generation (GO:0043046)3.37742190
38intracellular pH reduction (GO:0051452)3.32759291
39response to host (GO:0075136)3.27210906
40response to host defenses (GO:0052200)3.27210906
41response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.27210906
42cell wall macromolecule catabolic process (GO:0016998)3.27131157
43positive regulation of interferon-alpha production (GO:0032727)3.26867800
44regulation of triglyceride catabolic process (GO:0010896)3.26421468
45amyloid precursor protein catabolic process (GO:0042987)3.25728245
46purine deoxyribonucleotide catabolic process (GO:0009155)3.24573588
47positive regulation of mast cell degranulation (GO:0043306)3.22548401
48positive regulation of mast cell activation involved in immune response (GO:0033008)3.22548401
49cellular response to thyroid hormone stimulus (GO:0097067)3.17935859
50neutrophil mediated immunity (GO:0002446)3.17899776
51L-fucose catabolic process (GO:0042355)3.17763587
52fucose catabolic process (GO:0019317)3.17763587
53L-fucose metabolic process (GO:0042354)3.17763587
54detection of molecule of bacterial origin (GO:0032490)3.17737720
55negative regulation of granulocyte differentiation (GO:0030853)3.16760080
56immunoglobulin mediated immune response (GO:0016064)3.12083506
57regulation of leukocyte degranulation (GO:0043300)3.11259833
58ceramide catabolic process (GO:0046514)3.09342380
59negative regulation of B cell apoptotic process (GO:0002903)3.09111047
60cellular response to exogenous dsRNA (GO:0071360)3.08531224
61negative regulation of glycoprotein biosynthetic process (GO:0010561)3.04071921
62regulation of interferon-alpha production (GO:0032647)3.02334018
63negative regulation of interleukin-6 production (GO:0032715)3.01926720
64glycolipid catabolic process (GO:0019377)3.00770164
65germinal center formation (GO:0002467)2.98926814
66regulation of gamma-delta T cell activation (GO:0046643)2.97404649
67lymphocyte chemotaxis (GO:0048247)2.97017468
68positive regulation of defense response to virus by host (GO:0002230)2.96418219
69pH reduction (GO:0045851)2.95625563
70purinergic nucleotide receptor signaling pathway (GO:0035590)2.94027478
71regulation of histone phosphorylation (GO:0033127)2.93080517
72regulation of interleukin-8 biosynthetic process (GO:0045414)2.92437101
73DNA deamination (GO:0045006)2.91650789
74phagosome maturation (GO:0090382)2.91608842
75positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.90814373
76regulation of mast cell degranulation (GO:0043304)2.90575835
77negative regulation of interleukin-17 production (GO:0032700)2.90195689
78response to muramyl dipeptide (GO:0032495)2.89293886
79negative regulation of mast cell activation (GO:0033004)2.89238439
80regulation of mast cell activation (GO:0033003)2.88288023
81G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.87011599
82daunorubicin metabolic process (GO:0044597)2.85394213
83polyketide metabolic process (GO:0030638)2.85394213
84doxorubicin metabolic process (GO:0044598)2.85394213
85mannose metabolic process (GO:0006013)2.84629126
86response to xenobiotic stimulus (GO:0009410)2.83856193
87leukocyte degranulation (GO:0043299)2.82629128
88positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.80913430
89positive regulation of mast cell activation (GO:0033005)2.80493233
90myeloid leukocyte activation (GO:0002274)2.80432118
91basic amino acid transport (GO:0015802)2.80122890
92regulation of antigen processing and presentation (GO:0002577)2.79376242
93production of molecular mediator involved in inflammatory response (GO:0002532)2.79163306
94regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.78413824
95Arp2/3 complex-mediated actin nucleation (GO:0034314)2.77559023
96regulation of mast cell activation involved in immune response (GO:0033006)2.74455306
97regulation of regulated secretory pathway (GO:1903305)2.74058950
98negative regulation of cell cycle G2/M phase transition (GO:1902750)2.73942690
99T cell migration (GO:0072678)2.73286185
100negative regulation of innate immune response (GO:0045824)2.69700210
101positive regulation of histone deacetylation (GO:0031065)2.69272226
102regulation of gamma-delta T cell differentiation (GO:0045586)2.69166317
103regulation of defense response to virus by host (GO:0050691)2.68959654
104regulation of macrophage chemotaxis (GO:0010758)2.67096205
105regulation of mononuclear cell migration (GO:0071675)2.66391206
106positive regulation of B cell differentiation (GO:0045579)2.65557554
107regulation of B cell apoptotic process (GO:0002902)2.65073774
108response to peptidoglycan (GO:0032494)2.64599091
109oligosaccharide catabolic process (GO:0009313)2.64191578
110B cell receptor signaling pathway (GO:0050853)2.63657976
111phosphatidylglycerol biosynthetic process (GO:0006655)2.59791659
112deoxyribonucleotide catabolic process (GO:0009264)2.59625289
113regulation of hypersensitivity (GO:0002883)2.58976488
114RNA destabilization (GO:0050779)2.58757651
115neutrophil activation (GO:0042119)2.58082837
116positive regulation of toll-like receptor signaling pathway (GO:0034123)2.57669654
117pyrimidine nucleotide catabolic process (GO:0006244)2.57085869
118negative regulation of macroautophagy (GO:0016242)2.57036762
119pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.56740244
120regulation of chemokine secretion (GO:0090196)2.54880827
121regulation of interleukin-17 production (GO:0032660)2.53909981
122negative regulation of interleukin-8 production (GO:0032717)2.53854502
123tRNA modification (GO:0006400)2.53525600
124positive regulation of acute inflammatory response (GO:0002675)2.53049898
125I-kappaB phosphorylation (GO:0007252)2.52355445
126tRNA methylation (GO:0030488)2.51927227
127purinergic receptor signaling pathway (GO:0035587)2.51727248
128positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.51017042
129positive regulation of interleukin-17 production (GO:0032740)2.50593828
130cell wall macromolecule metabolic process (GO:0044036)2.50028599
131lytic vacuole organization (GO:0080171)2.50005184
132lysosome organization (GO:0007040)2.50005184
133neutrophil chemotaxis (GO:0030593)2.49650672
134positive regulation of developmental pigmentation (GO:0048087)2.48434254
135response to thyroid hormone (GO:0097066)2.48433442
136piRNA metabolic process (GO:0034587)2.46466950
137L-amino acid import (GO:0043092)2.45333602
138negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.44631210
139granulocyte activation (GO:0036230)2.43767044
140positive regulation of macrophage cytokine production (GO:0060907)2.43479420
141low-density lipoprotein particle remodeling (GO:0034374)2.41718917
142dendritic cell chemotaxis (GO:0002407)2.41664501
143neutrophil migration (GO:1990266)2.40380622
144response to lipoprotein particle (GO:0055094)2.39918681
145hepatocyte apoptotic process (GO:0097284)2.39840712
146negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.39381275
147negative regulation of cell killing (GO:0031342)2.39381275
148hyaluronan catabolic process (GO:0030214)2.39067875
149leukocyte migration involved in inflammatory response (GO:0002523)2.38466237
150myeloid leukocyte mediated immunity (GO:0002444)2.36863599
151regulation of myeloid leukocyte mediated immunity (GO:0002886)2.36364650
152regulation of cholesterol storage (GO:0010885)2.33911420
153keratan sulfate catabolic process (GO:0042340)2.32531246
154glycosylceramide metabolic process (GO:0006677)2.32495127
155disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.31899508

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse4.51358681
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.95829787
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.85876692
4IRF8_27001747_Chip-Seq_BMDM_Mouse3.58638270
5SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.40434399
6Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.29355805
7VDR_21846776_ChIP-Seq_THP-1_Human3.20918856
8CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.91433914
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.78295267
10* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.47833201
11* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.46258928
12GBX2_23144817_ChIP-Seq_PC3_Human2.31246696
13* VDR_24763502_ChIP-Seq_THP-1_Human2.29437166
14GATA1_22025678_ChIP-Seq_K562_Human2.25181762
15FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.18350470
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.08141312
17* BCL6_27268052_Chip-Seq_Bcells_Human2.06215887
18P68_20966046_ChIP-Seq_HELA_Human1.98390329
19VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.97121658
20* BCOR_27268052_Chip-Seq_Bcells_Human1.94415943
21TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.93159065
22NOTCH1_21737748_ChIP-Seq_TLL_Human1.89434204
23FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.89137006
24ELF1_20517297_ChIP-Seq_JURKAT_Human1.87364444
25SCL_19346495_ChIP-Seq_HPC-7_Human1.87303174
26TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.86465099
27JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.85257226
28RUNX_20019798_ChIP-Seq_JUKART_Human1.84836413
29* PHF8_20622854_ChIP-Seq_HELA_Human1.84196472
30THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.82624687
31CIITA_25753668_ChIP-Seq_RAJI_Human1.81844259
32TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.79444355
33STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.78246731
34UTX_26944678_Chip-Seq_JUKART_Human1.77729250
35EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.75927440
36LXR_22292898_ChIP-Seq_THP-1_Human1.75754555
37LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.75254730
38IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.74772719
39GATA2_21666600_ChIP-Seq_HMVEC_Human1.74585029
40MYC_22102868_ChIP-Seq_BL_Human1.74291518
41* E2F1_20622854_ChIP-Seq_HELA_Human1.72865641
42MAF_26560356_Chip-Seq_TH2_Human1.72104678
43RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.65263758
44SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.63904534
45NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.63781072
46SPI1_23127762_ChIP-Seq_K562_Human1.63588454
47ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.59327714
48IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.58435899
49EGR1_23403033_ChIP-Seq_LIVER_Mouse1.57278414
50RXR_22158963_ChIP-Seq_LIVER_Mouse1.55470015
51TET1_21451524_ChIP-Seq_MESCs_Mouse1.55243280
52* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.55185589
53PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.54809864
54LXR_22158963_ChIP-Seq_LIVER_Mouse1.53811259
55* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.53612866
56* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.53296157
57STAT6_21828071_ChIP-Seq_BEAS2B_Human1.51494878
58FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.50259175
59CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.49609469
60MAF_26560356_Chip-Seq_TH1_Human1.48589510
61SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.47916378
62VDR_24787735_ChIP-Seq_THP-1_Human1.46169435
63ZNF274_21170338_ChIP-Seq_K562_Hela1.44262687
64ETS1_20019798_ChIP-Seq_JURKAT_Human1.43234420
65P300_27268052_Chip-Seq_Bcells_Human1.38763932
66ELF1_17652178_ChIP-ChIP_JURKAT_Human1.37910821
67ELK3_25401928_ChIP-Seq_HUVEC_Human1.37120749
68DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.36629076
69AR_21572438_ChIP-Seq_LNCaP_Human1.36526693
70STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.36343334
71RAC3_21632823_ChIP-Seq_H3396_Human1.36046033
72PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.35699720
73KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.35476353
74* GABP_19822575_ChIP-Seq_HepG2_Human1.34934788
75RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.33889619
76* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.33422672
77* OCT4_19829295_ChIP-Seq_ESCs_Human1.32470153
78IKZF1_21737484_ChIP-ChIP_HCT116_Human1.31404720
79* RARB_24833708_ChIP-Seq_LIVER_Mouse1.31071185
80PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.30752479
81SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.30253571
82ZFP57_27257070_Chip-Seq_ESCs_Mouse1.29988586
83* SPI1_20517297_ChIP-Seq_HL60_Human1.28254663
84SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.26716949
85TP53_22127205_ChIP-Seq_IMR90_Human1.26499716
86VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.25397459
87NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.25319578
88CTCF_26484167_Chip-Seq_Bcells_Mouse1.24082821
89PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.23589039
90BRD4_27068464_Chip-Seq_AML-cells_Mouse1.23245548
91KDM2B_26808549_Chip-Seq_DND41_Human1.22820003
92* SMC4_20622854_ChIP-Seq_HELA_Human1.22411985
93PU_27001747_Chip-Seq_BMDM_Mouse1.22128422
94MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.22082362
95ERA_21632823_ChIP-Seq_H3396_Human1.20078211
96SA1_27219007_Chip-Seq_ERYTHROID_Human1.19957878
97PU.1_20513432_ChIP-Seq_Bcells_Mouse1.19777627
98TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.18905514
99TAF15_26573619_Chip-Seq_HEK293_Human1.18376657
100CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.18106618
101TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.17796132
102* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.17241224
103CTCF_27219007_Chip-Seq_ERYTHROID_Human1.16441938
104EZH2_22144423_ChIP-Seq_EOC_Human1.16266098
105FOXP3_21729870_ChIP-Seq_TREG_Human1.15976864
106PPARA_22158963_ChIP-Seq_LIVER_Mouse1.15638109
107DROSHA_22980978_ChIP-Seq_HELA_Human1.15462281
108CTCF_20526341_ChIP-Seq_ESCs_Human1.15330684
109GATA1_19941827_ChIP-Seq_MEL_Mouse1.12872329
110KDM5A_27292631_Chip-Seq_BREAST_Human1.12383417
111* TCF7_22412390_ChIP-Seq_EML_Mouse1.11488130
112* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.11435056
113* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.11435056
114SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.11366495
115* GATA2_19941826_ChIP-Seq_K562_Human1.11261471
116* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11255105
117PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.10690707
118FOXP1_21924763_ChIP-Seq_HESCs_Human1.10679728
119RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10613606
120STAT4_19710469_ChIP-ChIP_TH1__Mouse1.10586523
121STAT1_20625510_ChIP-Seq_HELA_Human1.10393407
122* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.10195639
123RARA_24833708_ChIP-Seq_LIVER_Mouse1.09253995
124CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.09197501
125SPI1_23547873_ChIP-Seq_NB4_Human1.08242855
126SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.08112904
127SRF_21415370_ChIP-Seq_HL-1_Mouse1.07414369
128SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06815033
129SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.06808948
130CTCF_21964334_ChIP-Seq_BJAB-B_Human1.06179081
131SA1_27219007_Chip-Seq_Bcells_Human1.05639933
132MYB_26560356_Chip-Seq_TH2_Human1.05539614
133RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.05292747
134SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.05218123
135SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.04230668
136SMAD_19615063_ChIP-ChIP_OVARY_Human1.02262073
137P300_19829295_ChIP-Seq_ESCs_Human1.02146256
138GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.01350314
139* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00424914
140NR3C1_23031785_ChIP-Seq_PC12_Mouse0.98886832
141NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.98554684
142BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.96296529
143PU1_27457419_Chip-Seq_LIVER_Mouse0.96144438
144RUNX1_22412390_ChIP-Seq_EML_Mouse0.95114623
145RXR_22108803_ChIP-Seq_LS180_Human0.93977289
146CDX2_19796622_ChIP-Seq_MESCs_Mouse0.93972898
147CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.93000467
148FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.91707369
149* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.91657592
150POU3F2_20337985_ChIP-ChIP_501MEL_Human0.90869354
151CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90399197
152* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.90053883
153SMAD4_21799915_ChIP-Seq_A2780_Human0.89986559
154MTF2_20144788_ChIP-Seq_MESCs_Mouse0.88439490
155STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.88216316
156KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.87735149
157NANOG_18555785_Chip-Seq_ESCs_Mouse0.87574906
158GATA3_26560356_Chip-Seq_TH2_Human0.87369249
159AR_25329375_ChIP-Seq_VCAP_Human0.86105067
160SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.85218596
161TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.84746905
162* PRDM14_20953172_ChIP-Seq_ESCs_Human0.84124423
163ER_23166858_ChIP-Seq_MCF-7_Human0.83934374
164EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.83930727
165* GATA1_19941826_ChIP-Seq_K562_Human0.83888847
166AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.83623515
167SMAD3_21741376_ChIP-Seq_EPCs_Human0.83589858
168P53_22387025_ChIP-Seq_ESCs_Mouse0.83413747
169PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.82991023
170CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.82472807
171CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.82116546
172SUZ12_18555785_Chip-Seq_ESCs_Mouse0.82033432
173GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81503234
174PIAS1_25552417_ChIP-Seq_VCAP_Human0.81490076

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology4.61659172
2MP0005058_abnormal_lysosome_morphology4.26972690
3MP0003191_abnormal_cellular_cholesterol3.93123989
4MP0003172_abnormal_lysosome_physiology3.88651365
5MP0006082_CNS_inflammation3.46588904
6MP0001835_abnormal_antigen_presentation3.29837297
7MP0003183_abnormal_peptide_metabolism3.21009976
8MP0002837_dystrophic_cardiac_calcinosis3.00360318
9MP0003646_muscle_fatigue2.81867757
10MP0003436_decreased_susceptibility_to2.78017120
11MP0003690_abnormal_glial_cell2.74905950
12MP0002419_abnormal_innate_immunity2.71791080
13MP0005171_absent_coat_pigmentation2.71423601
14MP0009840_abnormal_foam_cell2.57055769
15MP0005464_abnormal_platelet_physiology2.52957336
16MP0009278_abnormal_bone_marrow2.42155515
17MP0003303_peritoneal_inflammation2.23691031
18MP0003724_increased_susceptibility_to2.17415694
19MP0001986_abnormal_taste_sensitivity2.13017061
20MP0005000_abnormal_immune_tolerance2.01826311
21MP0003136_yellow_coat_color2.01666701
22MP0002148_abnormal_hypersensitivity_rea2.00966675
23MP0005671_abnormal_response_to1.96095517
24MP0003075_altered_response_to1.95750030
25MP0002138_abnormal_hepatobiliary_system1.93371766
26MP0005075_abnormal_melanosome_morpholog1.91724784
27MP0008260_abnormal_autophagy1.89679632
28MP0000604_amyloidosis1.87677350
29MP0002452_abnormal_antigen_presenting1.85196245
30MP0005025_abnormal_response_to1.85122255
31MP0003656_abnormal_erythrocyte_physiolo1.84572872
32MP0004381_abnormal_hair_follicle1.77860637
33MP0004510_myositis1.77580160
34MP0002139_abnormal_hepatobiliary_system1.67062670
35MP0009785_altered_susceptibility_to1.66881090
36MP0001800_abnormal_humoral_immune1.66058534
37MP0002723_abnormal_immune_serum1.64088536
38MP0001533_abnormal_skeleton_physiology1.59682474
39MP0002736_abnormal_nociception_after1.54969001
40MP0010329_abnormal_lipoprotein_level1.53700351
41MP0001819_abnormal_immune_cell1.51009098
42MP0002420_abnormal_adaptive_immunity1.50101312
43MP0005085_abnormal_gallbladder_physiolo1.48576520
44MP0008004_abnormal_stomach_pH1.48325501
45MP0004859_abnormal_synaptic_plasticity1.47415003
46MP0004147_increased_porphyrin_level1.46982874
47MP0001790_abnormal_immune_system1.45561413
48MP0005387_immune_system_phenotype1.45561413
49MP0004130_abnormal_muscle_cell1.44251052
50MP0001851_eye_inflammation1.42704932
51MP0005360_urolithiasis1.41453914
52MP0005310_abnormal_salivary_gland1.40461798
53MP0002102_abnormal_ear_morphology1.37922530
54MP0000920_abnormal_myelination1.37166716
55MP0002090_abnormal_vision1.33886345
56MP0008875_abnormal_xenobiotic_pharmacok1.32685768
57MP0010386_abnormal_urinary_bladder1.32326211
58MP0005166_decreased_susceptibility_to1.31497456
59MP0000465_gastrointestinal_hemorrhage1.30293364
60MP0001845_abnormal_inflammatory_respons1.28691596
61MP0008469_abnormal_protein_level1.27785657
62MP0000343_altered_response_to1.25899343
63MP0003828_pulmonary_edema1.25832638
64MP0001545_abnormal_hematopoietic_system1.22470794
65MP0005397_hematopoietic_system_phenotyp1.22470794
66MP0002064_seizures1.18682742
67MP0001873_stomach_inflammation1.16728813
68MP0005365_abnormal_bile_salt1.16624294
69MP0000015_abnormal_ear_pigmentation1.15583509
70MP0003633_abnormal_nervous_system1.15071127
71MP0009764_decreased_sensitivity_to1.12768154
72MP0002332_abnormal_exercise_endurance1.10636909
73MP0009763_increased_sensitivity_to1.10594619
74MP0005670_abnormal_white_adipose1.10335117
75MP0001968_abnormal_touch/_nociception1.08796396
76MP0000685_abnormal_immune_system1.08373873
77MP0002254_reproductive_system_inflammat1.05973512
78MP0005083_abnormal_biliary_tract1.04374308
79MP0001501_abnormal_sleep_pattern1.03976066
80MP0002405_respiratory_system_inflammati1.01995710
81MP0004233_abnormal_muscle_weight1.01563794
82MP0001853_heart_inflammation0.99551524
83MP0005167_abnormal_blood-brain_barrier0.98420165
84MP0008874_decreased_physiological_sensi0.97540480
85MP0002822_catalepsy0.96727532
86MP0002638_abnormal_pupillary_reflex0.96660417
87MP0003011_delayed_dark_adaptation0.96591270
88MP0005451_abnormal_body_composition0.96097149
89MP0003763_abnormal_thymus_physiology0.95032946
90MP0005076_abnormal_cell_differentiation0.94436138
91MP0002998_abnormal_bone_remodeling0.94226757
92MP0000716_abnormal_immune_system0.94201793
93MP0002095_abnormal_skin_pigmentation0.92659530
94MP0005174_abnormal_tail_pigmentation0.91795991
95MP0003879_abnormal_hair_cell0.89506404
96MP0000689_abnormal_spleen_morphology0.88939011
97MP0003878_abnormal_ear_physiology0.88799003
98MP0005377_hearing/vestibular/ear_phenot0.88799003
99MP0009745_abnormal_behavioral_response0.88746253
100MP0003880_abnormal_central_pattern0.87852440
101MP0003631_nervous_system_phenotype0.87698112
102MP0003252_abnormal_bile_duct0.86903903
103* MP0002118_abnormal_lipid_homeostasis0.85851907
104MP0004782_abnormal_surfactant_physiolog0.85704408
105MP0000569_abnormal_digit_pigmentation0.85134175
106MP0002876_abnormal_thyroid_physiology0.84294532
107MP0003632_abnormal_nervous_system0.81486775
108MP0002396_abnormal_hematopoietic_system0.81450500
109MP0000427_abnormal_hair_cycle0.80519398
110MP0001764_abnormal_homeostasis0.80214891
111MP0000358_abnormal_cell_content/0.78820816
112MP0001529_abnormal_vocalization0.78279560
113MP0009333_abnormal_splenocyte_physiolog0.77931244
114MP0000609_abnormal_liver_physiology0.77886210
115MP0002398_abnormal_bone_marrow0.76908710
116MP0005584_abnormal_enzyme/coenzyme_acti0.76532064
117MP0003634_abnormal_glial_cell0.76370331
118MP0003329_amyloid_beta_deposits0.76044977
119MP0001502_abnormal_circadian_rhythm0.75597302
120MP0003635_abnormal_synaptic_transmissio0.75382448
121MP0000249_abnormal_blood_vessel0.75272060
122MP0002429_abnormal_blood_cell0.73301779
123MP0010155_abnormal_intestine_physiology0.73151408
124MP0002229_neurodegeneration0.72774558
125MP0000750_abnormal_muscle_regeneration0.72615538
126MP0003045_fibrosis0.72366790
127MP0004883_abnormal_blood_vessel0.71396093
128MP0004133_heterotaxia0.70883713
129MP0009046_muscle_twitch0.70487876
130MP0004947_skin_inflammation0.70002164
131MP0005319_abnormal_enzyme/_coenzyme0.69618962
132MP0002075_abnormal_coat/hair_pigmentati0.69084879
133MP0006035_abnormal_mitochondrial_morpho0.66949169
134MP0002722_abnormal_immune_system0.65558901
135MP0001663_abnormal_digestive_system0.65361365
136MP0002572_abnormal_emotion/affect_behav0.65175895
137MP0005535_abnormal_body_temperature0.64883340
138MP0003806_abnormal_nucleotide_metabolis0.63191027
139MP0006054_spinal_hemorrhage0.61583651
140MP0000703_abnormal_thymus_morphology0.58687817
141MP0001486_abnormal_startle_reflex0.56736096
142MP0000371_diluted_coat_color0.55073562
143MP0002168_other_aberrant_phenotype0.54892686

Predicted human phenotypes

RankGene SetZ-score
1Increased cerebral lipofuscin (HP:0011813)6.57527570
2Systemic lupus erythematosus (HP:0002725)6.57060898
3Increased neuronal autofluorescent lipopigment (HP:0002074)6.02170207
4Abnormality of glycosphingolipid metabolism (HP:0004343)5.74930636
5Abnormality of glycolipid metabolism (HP:0010969)5.74930636
6Abnormality of liposaccharide metabolism (HP:0010968)5.74930636
7Vacuolated lymphocytes (HP:0001922)5.42236398
8Glomerulonephritis (HP:0000099)5.33385619
9Recurrent abscess formation (HP:0002722)5.06359675
10Complement deficiency (HP:0004431)4.79369079
11Recurrent bacterial skin infections (HP:0005406)4.63185484
12Dysostosis multiplex (HP:0000943)4.56399520
13Agnosia (HP:0010524)4.27021586
14Recurrent gram-negative bacterial infections (HP:0005420)4.27002185
15Abnormality of complement system (HP:0005339)3.87748457
16Abnormality of mucopolysaccharide metabolism (HP:0011020)3.85858934
17Abnormality of polysaccharide metabolism (HP:0011012)3.85858934
18Abnormality of glycosaminoglycan metabolism (HP:0004371)3.85858934
19Prostate neoplasm (HP:0100787)3.79367529
20Mucopolysacchariduria (HP:0008155)3.77281591
21Urinary glycosaminoglycan excretion (HP:0003541)3.77281591
22Amelogenesis imperfecta (HP:0000705)3.66619621
23Eczematoid dermatitis (HP:0000976)3.53552097
24Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.53338697
25Axonal loss (HP:0003447)3.44542472
26Retinal atrophy (HP:0001105)3.15798891
27Panhypogammaglobulinemia (HP:0003139)3.11185336
28Abnormality of macrophages (HP:0004311)3.05100844
29Recurrent skin infections (HP:0001581)2.95721825
30Albinism (HP:0001022)2.92950816
31Nephritis (HP:0000123)2.88947161
32Joint hemorrhage (HP:0005261)2.87475848
33Upper motor neuron abnormality (HP:0002127)2.80253516
34Elevated erythrocyte sedimentation rate (HP:0003565)2.73644693
35Agammaglobulinemia (HP:0004432)2.72213583
36Loss of speech (HP:0002371)2.69687571
37Stomatitis (HP:0010280)2.69051990
38Congenital stationary night blindness (HP:0007642)2.67758592
39Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.66966998
40Myositis (HP:0100614)2.65360059
41Amyloidosis (HP:0011034)2.60336093
42Hepatosplenomegaly (HP:0001433)2.59802896
43Abnormal delayed hypersensitivity skin test (HP:0002963)2.57236034
44Petechiae (HP:0000967)2.54132792
45Myocardial infarction (HP:0001658)2.48520823
46Disinhibition (HP:0000734)2.47659489
47Abnormality of the prostate (HP:0008775)2.47584721
48Focal motor seizures (HP:0011153)2.40689296
49Decreased electroretinogram (ERG) amplitude (HP:0000654)2.39744017
50Gingivitis (HP:0000230)2.39223764
51Pustule (HP:0200039)2.38911115
52Parakeratosis (HP:0001036)2.36904366
53Molar tooth sign on MRI (HP:0002419)2.36562954
54Abnormality of midbrain morphology (HP:0002418)2.36562954
55Neuronal loss in central nervous system (HP:0002529)2.35437012
56Progressive neurologic deterioration (HP:0002344)2.33918800
57Chronic obstructive pulmonary disease (HP:0006510)2.31558413
58Obstructive lung disease (HP:0006536)2.31558413
59Progressive visual loss (HP:0000529)2.30100874
60Arterial tortuosity (HP:0005116)2.28156000
61Deformed sella turcica (HP:0002681)2.27030366
62Mutism (HP:0002300)2.26873879
63Severe combined immunodeficiency (HP:0004430)2.25636487
64Neurofibrillary tangles (HP:0002185)2.24327532
65Microvesicular hepatic steatosis (HP:0001414)2.24118309
66Orchitis (HP:0100796)2.23983178
67J-shaped sella turcica (HP:0002680)2.22014872
68Global brain atrophy (HP:0002283)2.20087988
69Anterior segment dysgenesis (HP:0007700)2.18509622
70Severe visual impairment (HP:0001141)2.17686391
71Thrombocytosis (HP:0001894)2.16086558
72Granulocytopenia (HP:0001913)2.15945714
73Spontaneous hematomas (HP:0007420)2.14113126
74Mediastinal lymphadenopathy (HP:0100721)2.13981210
75Abnormality of B cell number (HP:0010975)2.12110851
76Gastrointestinal stroma tumor (HP:0100723)2.10465836
77Periodontitis (HP:0000704)2.08894459
78Thoracic kyphosis (HP:0002942)2.06751895
79Partial agenesis of the corpus callosum (HP:0001338)2.05091472
80Retrobulbar optic neuritis (HP:0100654)2.02114517
81Optic neuritis (HP:0100653)2.02114517
82Hemoptysis (HP:0002105)2.01675527
83Basal ganglia calcification (HP:0002135)2.01518513
84Prolonged bleeding time (HP:0003010)1.99933788
85Progressive microcephaly (HP:0000253)1.99388816
86Autoimmune thrombocytopenia (HP:0001973)1.99044665
87Asymmetric septal hypertrophy (HP:0001670)1.98115486
88Pancreatic cysts (HP:0001737)1.97996269
89Gastrointestinal inflammation (HP:0004386)1.97689388
90Epistaxis (HP:0000421)1.97398230
91Hypoplasia of the thymus (HP:0000778)1.97057537
92Absent rod-and cone-mediated responses on ERG (HP:0007688)1.96081099
93Leukocytosis (HP:0001974)1.95587349
94Hypercholesterolemia (HP:0003124)1.95138035
95Xanthomatosis (HP:0000991)1.94560994
96Sepsis (HP:0100806)1.94382319
97Visual hallucinations (HP:0002367)1.92707644
98Cerebellar dysplasia (HP:0007033)1.91798105
99Hyperlipoproteinemia (HP:0010980)1.91409787
100Spastic tetraparesis (HP:0001285)1.90782153
101Nephronophthisis (HP:0000090)1.90672750
102Vasculitis (HP:0002633)1.90188042
103Pathologic fracture (HP:0002756)1.90062318
104Cellulitis (HP:0100658)1.89631986
105Peripheral demyelination (HP:0011096)1.89573332
106Clumsiness (HP:0002312)1.88224086
107Lissencephaly (HP:0001339)1.88153300
108Abnormality of eosinophils (HP:0001879)1.88084323
109Deep venous thrombosis (HP:0002625)1.88054979
110Increased serum ferritin (HP:0003281)1.87200542
111Progressive inability to walk (HP:0002505)1.86532804
112Vascular tortuosity (HP:0004948)1.86405541
113Difficulty walking (HP:0002355)1.86340582
114Lower limb hyperreflexia (HP:0002395)1.85976223
115Recurrent viral infections (HP:0004429)1.85958609
116Abnormality of transition element cation homeostasis (HP:0011030)1.85939672
117Prolonged partial thromboplastin time (HP:0003645)1.84736225
118Chest pain (HP:0100749)1.84645625
119Inability to walk (HP:0002540)1.84249758
120Chronic diarrhea (HP:0002028)1.84056197
121Chronic mucocutaneous candidiasis (HP:0002728)1.83893325
122Recurrent cutaneous fungal infections (HP:0011370)1.83893325
123Retinal dysplasia (HP:0007973)1.83756316
124Colitis (HP:0002583)1.83492050
125Opisthotonus (HP:0002179)1.83264174
126Abnormality of the periventricular white matter (HP:0002518)1.82113010
127Chronic hepatic failure (HP:0100626)1.80126938
128B lymphocytopenia (HP:0010976)1.79015199
129Cheilitis (HP:0100825)1.78343601
130Pendular nystagmus (HP:0012043)1.78155714
131Osteomyelitis (HP:0002754)1.76815733
132Hematochezia (HP:0002573)1.76814275
133Eosinophilia (HP:0001880)1.76805052
134Pulmonary infiltrates (HP:0002113)1.76570685
135Combined immunodeficiency (HP:0005387)1.75847319
136Meningitis (HP:0001287)1.75512213
137Abnormality of the vasculature of the conjunctiva (HP:0008054)1.75320558
138Inflammation of the large intestine (HP:0002037)1.74373567
139Type II lissencephaly (HP:0007260)1.74335278
140Hypoplasia of the brainstem (HP:0002365)1.73268386
141Aplasia/Hypoplasia of the brainstem (HP:0007362)1.73268386
142Abnormality of iron homeostasis (HP:0011031)1.71904830
143Gingival bleeding (HP:0000225)1.71758545
144Polyphagia (HP:0002591)1.71488992
145Impaired platelet aggregation (HP:0003540)1.71213607
146Abnormal platelet function (HP:0011869)1.71213607
147Inappropriate behavior (HP:0000719)1.71147472
148Recurrent fungal infections (HP:0002841)1.70988140
149Abnormal rod and cone electroretinograms (HP:0008323)1.70851465
150Keratoconjunctivitis sicca (HP:0001097)1.69255566
151Bundle branch block (HP:0011710)1.68276070
152Dementia (HP:0000726)1.67775350
153Cardiomegaly (HP:0001640)1.67656102
154Urticaria (HP:0001025)1.67114534
155Sensorimotor neuropathy (HP:0007141)1.66051235
156Failure to thrive in infancy (HP:0001531)1.65601019
157Urethral obstruction (HP:0000796)1.65099390
158Spondylolisthesis (HP:0003302)1.64777640
159Abolished electroretinogram (ERG) (HP:0000550)1.64635583
160Myoclonus (HP:0001336)1.63964719

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PIK3CG5.45417678
2RIPK44.13881914
3TGFBR23.62399627
4MAPK153.51278509
5TESK23.35891252
6KIT3.01609282
7MAP3K142.93261177
8BLK2.92912573
9CSF1R2.44087291
10LATS12.16181780
11GRK72.09877267
12PRKD22.08802522
13MAP3K132.05584377
14ZAK2.04979590
15TYK22.03915060
16IRAK42.01221724
17CASK1.98907938
18MAP3K111.95393206
19PRKD31.82875589
20PRPF4B1.80722622
21GRK61.72680377
22MAP2K21.67458320
23PIM21.60551032
24IRAK31.57625296
25MAP4K11.52831195
26BCKDK1.49949478
27TAOK31.48001295
28CDK91.47890966
29MAP4K21.44152307
30TNK21.43955468
31CLK11.43621917
32FES1.41527612
33BMPR21.38944529
34JAK11.37249293
35NEK91.36213601
36CAMKK21.34259751
37MATK1.31930014
38VRK21.29395621
39MARK31.29207294
40MAP3K61.25969072
41TBK11.24279725
42MARK21.23838693
43MAP2K31.20651181
44MAP3K121.17431180
45SYK1.17276287
46FGR1.13394090
47PAK61.13026553
48SGK21.11885179
49HCK1.06633942
50MAP2K71.06387224
51STK381.05084011
52TAOK11.04878425
53ERN11.04544704
54DAPK21.03282201
55SIK31.01632499
56SIK20.99952069
57EPHA40.98612405
58TXK0.97930063
59SMG10.97315322
60TLK10.96708011
61KSR20.94705344
62ZAP700.93117617
63JAK30.92390189
64NTRK30.91970585
65STK38L0.91890178
66LYN0.89998031
67CAMK1D0.89454937
68MAPK120.88540307
69STK110.87783188
70CSNK1A1L0.87565265
71MAP2K40.87489759
72SGK30.85370129
73LCK0.84347132
74MOS0.84343755
75PINK10.83692888
76CAMKK10.83248308
77FLT30.83121542
78JAK20.81169287
79FRK0.80466042
80IKBKB0.80299739
81CCNB10.79113970
82TEC0.77757996
83TRPM70.76749312
84SGK2230.75559738
85SGK4940.75559738
86LATS20.75479407
87ICK0.74778925
88ADRBK20.74578290
89BTK0.73407445
90CSK0.72307746
91PRKCH0.70872964
92MAPK130.69858561
93BRAF0.69773274
94RAF10.69652381
95PLK20.68622332
96MAPK70.67370024
97ITK0.67214413
98PRKCI0.67185229
99PIK3CA0.66493634
100MAPKAPK50.66250833
101TNIK0.63533059
102ADRBK10.63230385
103MAP3K70.63152050
104EPHA30.62732719
105PRKD10.61434963
106INSRR0.61407272
107MAP2K60.60826419
108CAMK1G0.60143670
109MELK0.59126785
110GRK50.55905730
111RPS6KA60.52513710
112PDK10.50773800
113PTK2B0.50679328
114CDK30.50358631
115CDK190.50067411
116IKBKE0.49904333
117MAP3K40.49753910
118CDK80.49702512
119MAP3K30.49670847
120AKT30.49660954
121YES10.48893026
122PIM10.48863879
123KDR0.48421368
124VRK10.48284357
125PDPK10.47931463
126CHUK0.46854042
127ACVR1B0.45481972
128PRKAA20.45099373
129IGF1R0.44742255
130GRK10.44169349
131PRKCQ0.44025020
132DAPK10.43767346
133MAP3K90.42854358
134MAP3K10.42499829
135ABL20.41452194
136MUSK0.41124634
137SIK10.39299726
138CAMK40.39197311
139PRKG10.37895065
140RPS6KA20.37880529
141EIF2AK20.36152367
142NUAK10.35558596
143EPHB10.34910795
144MAPK40.34198758
145PRKCD0.32998926
146PKN10.32765837
147ARAF0.32557488
148NTRK20.32201786
149STK100.31350259

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051504.22544846
2Glycosaminoglycan degradation_Homo sapiens_hsa005313.82389756
3Other glycan degradation_Homo sapiens_hsa005113.81003347
4Lysosome_Homo sapiens_hsa041423.40151283
5Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.63917663
6Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.42183609
7Complement and coagulation cascades_Homo sapiens_hsa046102.41114249
8Primary immunodeficiency_Homo sapiens_hsa053402.14550777
9Osteoclast differentiation_Homo sapiens_hsa043802.07433128
10Sulfur relay system_Homo sapiens_hsa041221.94428322
11Intestinal immune network for IgA production_Homo sapiens_hsa046721.82392009
12Acute myeloid leukemia_Homo sapiens_hsa052211.75155267
13Leishmaniasis_Homo sapiens_hsa051401.72536597
14Pertussis_Homo sapiens_hsa051331.69955518
15Phagosome_Homo sapiens_hsa041451.68027315
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.67921968
17B cell receptor signaling pathway_Homo sapiens_hsa046621.61103698
18Toll-like receptor signaling pathway_Homo sapiens_hsa046201.60882177
19Phototransduction_Homo sapiens_hsa047441.59220708
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.58834461
21Rheumatoid arthritis_Homo sapiens_hsa053231.56047411
22Tuberculosis_Homo sapiens_hsa051521.55420167
23Collecting duct acid secretion_Homo sapiens_hsa049661.55222117
24Primary bile acid biosynthesis_Homo sapiens_hsa001201.51881451
25Asthma_Homo sapiens_hsa053101.42246274
26Caffeine metabolism_Homo sapiens_hsa002321.38449409
27Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.38089657
28ABC transporters_Homo sapiens_hsa020101.34273138
29Synaptic vesicle cycle_Homo sapiens_hsa047211.31715982
30NOD-like receptor signaling pathway_Homo sapiens_hsa046211.22787967
31Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.21793329
32Regulation of autophagy_Homo sapiens_hsa041401.21687653
33Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.17465811
34Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.14765148
35Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.13305409
36Pentose and glucuronate interconversions_Homo sapiens_hsa000401.09929132
37Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.06671283
38Prion diseases_Homo sapiens_hsa050201.06471140
39Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.04295751
40alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.03374001
41Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.01452325
42Carbohydrate digestion and absorption_Homo sapiens_hsa049731.00142154
43Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.98704095
44Malaria_Homo sapiens_hsa051440.96232553
45Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.95154756
46PPAR signaling pathway_Homo sapiens_hsa033200.95006331
47Nitrogen metabolism_Homo sapiens_hsa009100.94762414
48Type II diabetes mellitus_Homo sapiens_hsa049300.93909414
49Sphingolipid metabolism_Homo sapiens_hsa006000.91770360
50Allograft rejection_Homo sapiens_hsa053300.91439264
51Graft-versus-host disease_Homo sapiens_hsa053320.91344009
52Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.90146697
53Nicotine addiction_Homo sapiens_hsa050330.85360527
54N-Glycan biosynthesis_Homo sapiens_hsa005100.83482393
55Dorso-ventral axis formation_Homo sapiens_hsa043200.81444406
56Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.81435940
57Histidine metabolism_Homo sapiens_hsa003400.80642170
58Chemokine signaling pathway_Homo sapiens_hsa040620.80347629
59Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.79955631
60Morphine addiction_Homo sapiens_hsa050320.78929321
61VEGF signaling pathway_Homo sapiens_hsa043700.78923742
62Viral myocarditis_Homo sapiens_hsa054160.78670584
63Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.77947536
64Notch signaling pathway_Homo sapiens_hsa043300.76766949
65Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.75444304
66Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.74143218
67Taste transduction_Homo sapiens_hsa047420.73669926
68Autoimmune thyroid disease_Homo sapiens_hsa053200.72971248
69Hematopoietic cell lineage_Homo sapiens_hsa046400.72752775
70Endocytosis_Homo sapiens_hsa041440.72517114
71Shigellosis_Homo sapiens_hsa051310.72385563
72Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.70939620
73Platelet activation_Homo sapiens_hsa046110.68467362
74Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.68465952
75Toxoplasmosis_Homo sapiens_hsa051450.68013312
76Ovarian steroidogenesis_Homo sapiens_hsa049130.66377824
77Phosphatidylinositol signaling system_Homo sapiens_hsa040700.66377494
78* Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.66217149
79Arginine biosynthesis_Homo sapiens_hsa002200.64990164
80Renin secretion_Homo sapiens_hsa049240.63643232
81Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.62670353
82Vibrio cholerae infection_Homo sapiens_hsa051100.62228124
83Ether lipid metabolism_Homo sapiens_hsa005650.62088811
84Legionellosis_Homo sapiens_hsa051340.61191805
85Olfactory transduction_Homo sapiens_hsa047400.60961837
86Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.60492866
87Peroxisome_Homo sapiens_hsa041460.60411135
88SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60091000
89Influenza A_Homo sapiens_hsa051640.59973672
90Bladder cancer_Homo sapiens_hsa052190.57848835
91Herpes simplex infection_Homo sapiens_hsa051680.57667359
92beta-Alanine metabolism_Homo sapiens_hsa004100.57377584
93Fatty acid elongation_Homo sapiens_hsa000620.56972047
94Retinol metabolism_Homo sapiens_hsa008300.56857683
95NF-kappa B signaling pathway_Homo sapiens_hsa040640.56669469
96Systemic lupus erythematosus_Homo sapiens_hsa053220.56502997
97Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55604514
98Pancreatic cancer_Homo sapiens_hsa052120.55147477
99Non-homologous end-joining_Homo sapiens_hsa034500.54443103
100Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.54306409
101Circadian entrainment_Homo sapiens_hsa047130.54241679
102Inositol phosphate metabolism_Homo sapiens_hsa005620.54155579
103Glutamatergic synapse_Homo sapiens_hsa047240.53940506
104Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.53207148
105Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.52538323
106African trypanosomiasis_Homo sapiens_hsa051430.52363531
107Sphingolipid signaling pathway_Homo sapiens_hsa040710.52224496
108Base excision repair_Homo sapiens_hsa034100.51925539
109Hepatitis C_Homo sapiens_hsa051600.51502524
110Measles_Homo sapiens_hsa051620.51355234
111Starch and sucrose metabolism_Homo sapiens_hsa005000.50287052
112Hepatitis B_Homo sapiens_hsa051610.50235536
113Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50134543
114Fatty acid degradation_Homo sapiens_hsa000710.48202470
115Viral carcinogenesis_Homo sapiens_hsa052030.48199937
116Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.47618285
117Salivary secretion_Homo sapiens_hsa049700.47156883
118GABAergic synapse_Homo sapiens_hsa047270.46760031
119Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.46375525
120Transcriptional misregulation in cancer_Homo sapiens_hsa052020.45794048
121Cholinergic synapse_Homo sapiens_hsa047250.44767860
122Apoptosis_Homo sapiens_hsa042100.44361209
123Fanconi anemia pathway_Homo sapiens_hsa034600.44309020
124Sulfur metabolism_Homo sapiens_hsa009200.42023788
125cAMP signaling pathway_Homo sapiens_hsa040240.41767033
126Lysine degradation_Homo sapiens_hsa003100.41267164
127Calcium signaling pathway_Homo sapiens_hsa040200.39904543
128Glycerophospholipid metabolism_Homo sapiens_hsa005640.39852846
129Choline metabolism in cancer_Homo sapiens_hsa052310.39748169
130Colorectal cancer_Homo sapiens_hsa052100.39072548
131Chemical carcinogenesis_Homo sapiens_hsa052040.38982795
132TNF signaling pathway_Homo sapiens_hsa046680.38863758
133Serotonergic synapse_Homo sapiens_hsa047260.38825291
134Oxytocin signaling pathway_Homo sapiens_hsa049210.37616986
135Salmonella infection_Homo sapiens_hsa051320.36972082
136Neurotrophin signaling pathway_Homo sapiens_hsa047220.36734189
137RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.36294975
138* Aldosterone synthesis and secretion_Homo sapiens_hsa049250.35759576
139Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.34623145
140Arachidonic acid metabolism_Homo sapiens_hsa005900.33496611
141Phospholipase D signaling pathway_Homo sapiens_hsa040720.33261477
142Antigen processing and presentation_Homo sapiens_hsa046120.32950130
143GnRH signaling pathway_Homo sapiens_hsa049120.32618178
144Jak-STAT signaling pathway_Homo sapiens_hsa046300.31738709
145Amoebiasis_Homo sapiens_hsa051460.30949719

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