DALRD3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The exact function of this gene is not known. It encodes a protein with a DALR anticodon binding domain similar to that of class Ia aminoacyl tRNA synthetases. This gene is located in a cluster of genes (with a complex sense-anti-sense genome architecture) on chromosome 3, and contains two micro RNA (miRNA) precursors (mir-425 and mir-191) in one of its introns. Preferential expression of this gene (the miRNAs and other genes in the cluster) in testis suggests a role of this gene in spermatogenesis (PMID:19906709). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.51251045
2epithelial cilium movement (GO:0003351)5.28311558
3ribosomal small subunit assembly (GO:0000028)5.10535323
4DNA deamination (GO:0045006)5.06680209
5behavioral response to nicotine (GO:0035095)4.96791642
6GTP biosynthetic process (GO:0006183)4.52190958
7viral transcription (GO:0019083)4.46547140
8pattern specification involved in kidney development (GO:0061004)4.40273759
9protein neddylation (GO:0045116)4.32726572
10translational termination (GO:0006415)4.25163979
11SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.08521667
12regulation of oxidative phosphorylation (GO:0002082)4.05276926
13establishment of protein localization to mitochondrial membrane (GO:0090151)4.03003801
14cotranslational protein targeting to membrane (GO:0006613)4.02478834
15CTP biosynthetic process (GO:0006241)4.00044205
16CTP metabolic process (GO:0046036)4.00044205
17guanosine-containing compound biosynthetic process (GO:1901070)3.97153442
18protein targeting to ER (GO:0045047)3.96695542
19UTP biosynthetic process (GO:0006228)3.89157620
20regulation of cilium movement (GO:0003352)3.83954470
21protein localization to endoplasmic reticulum (GO:0070972)3.82123976
22chaperone-mediated protein transport (GO:0072321)3.75357646
23nonmotile primary cilium assembly (GO:0035058)3.75110564
24establishment of protein localization to endoplasmic reticulum (GO:0072599)3.72853847
25translational elongation (GO:0006414)3.70953354
26respiratory chain complex IV assembly (GO:0008535)3.68581525
27cilium or flagellum-dependent cell motility (GO:0001539)3.68187664
28UTP metabolic process (GO:0046051)3.67989608
29ribosomal small subunit biogenesis (GO:0042274)3.64862593
30pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.57296207
31substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.56924520
32substrate-independent telencephalic tangential migration (GO:0021826)3.56924520
33pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.43411537
34protein maturation by protein folding (GO:0022417)3.41570907
35protein complex biogenesis (GO:0070271)3.38613675
36pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.37429414
37cell proliferation in forebrain (GO:0021846)3.37004067
38intraciliary transport (GO:0042073)3.36834880
39neuron fate determination (GO:0048664)3.29957760
40base-excision repair, AP site formation (GO:0006285)3.29866470
41viral life cycle (GO:0019058)3.28779122
42pyrimidine nucleobase catabolic process (GO:0006208)3.28228944
43segment specification (GO:0007379)3.27356915
44cellular protein complex disassembly (GO:0043624)3.23946746
45left/right pattern formation (GO:0060972)3.21542267
46RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.21219650
47tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.21219650
48cytochrome complex assembly (GO:0017004)3.19200059
49water-soluble vitamin biosynthetic process (GO:0042364)3.18494436
50polyketide metabolic process (GO:0030638)3.17118673
51doxorubicin metabolic process (GO:0044598)3.17118673
52daunorubicin metabolic process (GO:0044597)3.17118673
53mitochondrial respiratory chain complex assembly (GO:0033108)3.14016770
54motile cilium assembly (GO:0044458)3.13773257
55cornea development in camera-type eye (GO:0061303)3.13174360
56ATP synthesis coupled proton transport (GO:0015986)3.12805925
57energy coupled proton transport, down electrochemical gradient (GO:0015985)3.12805925
58protein-cofactor linkage (GO:0018065)3.12129546
59negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.11432028
60postsynaptic membrane organization (GO:0001941)3.09490096
61regulation of microtubule-based movement (GO:0060632)3.08170879
62pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.07823663
63catecholamine transport (GO:0051937)3.07427850
64cilium morphogenesis (GO:0060271)3.06614730
65maturation of SSU-rRNA (GO:0030490)3.05603826
66mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.02500611
67nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.99058280
68pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.98459360
69tRNA methylation (GO:0030488)2.97634812
70mitochondrial respiratory chain complex I assembly (GO:0032981)2.97322852
71NADH dehydrogenase complex assembly (GO:0010257)2.97322852
72mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.97322852
73protein polyglutamylation (GO:0018095)2.97001650
74neuron cell-cell adhesion (GO:0007158)2.96972187
75somite development (GO:0061053)2.96253044
76aminoglycoside antibiotic metabolic process (GO:0030647)2.96202986
77mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.93521570
78axoneme assembly (GO:0035082)2.93084828
79regulation of mitochondrial translation (GO:0070129)2.92817010
80cilium organization (GO:0044782)2.92746302
81nephron tubule morphogenesis (GO:0072078)2.89525517
82nephron epithelium morphogenesis (GO:0072088)2.89525517
83cilium assembly (GO:0042384)2.88140828
84sequestering of actin monomers (GO:0042989)2.85448736
85protein complex disassembly (GO:0043241)2.85222760
86dopamine transport (GO:0015872)2.83735347
87tongue development (GO:0043586)2.80259710
88hydrogen ion transmembrane transport (GO:1902600)2.79344449
89positive regulation of synaptic transmission, GABAergic (GO:0032230)2.79036615
90ATP biosynthetic process (GO:0006754)2.78507516
91deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.78257636
92retinal rod cell development (GO:0046548)2.77453390
93pyrimidine nucleotide catabolic process (GO:0006244)2.76982017
94retinal ganglion cell axon guidance (GO:0031290)2.74145804
95positive regulation of mitochondrial fission (GO:0090141)2.73013780
96protein localization to cilium (GO:0061512)2.71424408
97positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.70802573
98electron transport chain (GO:0022900)2.70227034
99macromolecular complex disassembly (GO:0032984)2.68565202
100regulation of autophagic vacuole assembly (GO:2000785)2.68326830
101positive regulation of gastrulation (GO:2000543)2.68009041
102regulation of short-term neuronal synaptic plasticity (GO:0048172)2.66094551
103nucleobase catabolic process (GO:0046113)2.65970011
104cerebral cortex radially oriented cell migration (GO:0021799)2.65731442
105protein localization to synapse (GO:0035418)2.65630066
106respiratory electron transport chain (GO:0022904)2.64590012
107proton transport (GO:0015992)2.64404642
108translational initiation (GO:0006413)2.64166770
109glycoside metabolic process (GO:0016137)2.63850385
110fucose catabolic process (GO:0019317)2.62801634
111L-fucose metabolic process (GO:0042354)2.62801634
112L-fucose catabolic process (GO:0042355)2.62801634
113microtubule bundle formation (GO:0001578)2.62568645
114nucleoside diphosphate phosphorylation (GO:0006165)2.62179779
115axonemal dynein complex assembly (GO:0070286)2.61228995
116response to misfolded protein (GO:0051788)2.60618934
117pyrimidine ribonucleoside biosynthetic process (GO:0046132)2.60353953
118GMP metabolic process (GO:0046037)2.60195647
119axonal fasciculation (GO:0007413)2.59282428
120phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.59157360
121intracellular protein transmembrane import (GO:0044743)2.58999294
122S-adenosylmethionine metabolic process (GO:0046500)2.58961094
123dendritic spine morphogenesis (GO:0060997)2.58788340
124folic acid metabolic process (GO:0046655)2.58636514
125hydrogen transport (GO:0006818)2.57865243
126translation (GO:0006412)2.55696987
127protein targeting to membrane (GO:0006612)2.54908871
128pyrimidine ribonucleotide biosynthetic process (GO:0009220)2.54393045
129cilium movement (GO:0003341)2.53896020
130synaptic vesicle exocytosis (GO:0016079)2.53594639
131response to ischemia (GO:0002931)2.53431166
132central nervous system myelination (GO:0022010)2.53262663
133axon ensheathment in central nervous system (GO:0032291)2.53262663
134neurotransmitter secretion (GO:0007269)2.51950717
135negative regulation of cAMP-mediated signaling (GO:0043951)2.51870669
136response to parathyroid hormone (GO:0071107)2.50516153
137purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.50097601
138regulation of synaptic vesicle transport (GO:1902803)2.49938993
139regulation of cellular respiration (GO:0043457)2.49631041
140regulation of synaptic vesicle exocytosis (GO:2000300)2.48900739
141pyrimidine ribonucleotide metabolic process (GO:0009218)2.48884032
142sensory perception of smell (GO:0007608)2.48436622
143ribosomal large subunit biogenesis (GO:0042273)2.48373056
144pseudouridine synthesis (GO:0001522)2.47872466
145pyrimidine nucleoside biosynthetic process (GO:0046134)2.47825948
146purine nucleoside triphosphate biosynthetic process (GO:0009145)2.44191561
147quinone biosynthetic process (GO:1901663)2.43177589
148ubiquinone biosynthetic process (GO:0006744)2.43177589
149GDP-mannose metabolic process (GO:0019673)2.43054015
150response to pheromone (GO:0019236)2.42819577
151ribonucleoside triphosphate biosynthetic process (GO:0009201)2.41838512
152positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.40011500
153regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.36608610

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.57310557
2EZH2_22144423_ChIP-Seq_EOC_Human5.54609810
3CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons3.17973405
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.17541344
5HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.06193803
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.70608675
7* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.59060653
8CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.38609917
9SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.31906497
10* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.22858973
11IKZF1_21737484_ChIP-ChIP_HCT116_Human2.11697038
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.07342130
13REST_21632747_ChIP-Seq_MESCs_Mouse1.95318345
14CBX2_27304074_Chip-Seq_ESCs_Mouse1.95002627
15* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.93523062
16SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.93290325
17ELF1_17652178_ChIP-ChIP_JURKAT_Human1.92049023
18LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.91581486
19MYC_18555785_ChIP-Seq_MESCs_Mouse1.90777553
20RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.89289389
21SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.88674100
22HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.88550053
23THAP11_20581084_ChIP-Seq_MESCs_Mouse1.85266863
24* GABP_17652178_ChIP-ChIP_JURKAT_Human1.84944188
25* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.84572796
26SCL_19346495_ChIP-Seq_HPC-7_Human1.84305280
27PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.84074696
28MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.78973558
29* REST_18959480_ChIP-ChIP_MESCs_Mouse1.74317143
30IGF1R_20145208_ChIP-Seq_DFB_Human1.73804820
31CTCF_18555785_ChIP-Seq_MESCs_Mouse1.72983919
32TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.67941802
33EST1_17652178_ChIP-ChIP_JURKAT_Human1.66362198
34BMI1_23680149_ChIP-Seq_NPCS_Mouse1.64696485
35SRF_21415370_ChIP-Seq_HL-1_Mouse1.64516257
36NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.62407008
37CIITA_25753668_ChIP-Seq_RAJI_Human1.62178262
38CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.61984117
39NOTCH1_21737748_ChIP-Seq_TLL_Human1.59834662
40YY1_21170310_ChIP-Seq_MESCs_Mouse1.56081812
41JARID2_20064375_ChIP-Seq_MESCs_Mouse1.54710540
42TET1_21451524_ChIP-Seq_MESCs_Mouse1.51907952
43SRY_22984422_ChIP-ChIP_TESTIS_Rat1.51059591
44FOXP3_21729870_ChIP-Seq_TREG_Human1.50552486
45SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.48437295
46EZH2_27294783_Chip-Seq_ESCs_Mouse1.46978701
47GATA1_22025678_ChIP-Seq_K562_Human1.45944714
48SUZ12_27294783_Chip-Seq_ESCs_Mouse1.45898945
49SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.42773419
50EED_16625203_ChIP-ChIP_MESCs_Mouse1.42629234
51* LXR_22292898_ChIP-Seq_THP-1_Human1.42323820
52MYC_18940864_ChIP-ChIP_HL60_Human1.41992823
53JARID2_20075857_ChIP-Seq_MESCs_Mouse1.41883631
54ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.41491827
55KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.40512586
56YY1_22570637_ChIP-Seq_MALME-3M_Human1.38292683
57HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.36745244
58DNAJC2_21179169_ChIP-ChIP_NT2_Human1.32725800
59ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.32369644
60PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.32134251
61SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.32049215
62RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.30506424
63* XRN2_22483619_ChIP-Seq_HELA_Human1.30354777
64* GABP_19822575_ChIP-Seq_HepG2_Human1.30027467
65VDR_22108803_ChIP-Seq_LS180_Human1.29269028
66RNF2_27304074_Chip-Seq_ESCs_Mouse1.27947923
67VDR_23849224_ChIP-Seq_CD4+_Human1.27480640
68* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.27058157
69* SA1_27219007_Chip-Seq_ERYTHROID_Human1.26818897
70LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.26815760
71CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.24636716
72ERG_20887958_ChIP-Seq_HPC-7_Mouse1.24409041
73SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.23994152
74ERA_21632823_ChIP-Seq_H3396_Human1.23356255
75KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.22835682
76* VDR_21846776_ChIP-Seq_THP-1_Human1.22617188
77TP63_19390658_ChIP-ChIP_HaCaT_Human1.22557693
78TP53_22573176_ChIP-Seq_HFKS_Human1.21600863
79EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.21034339
80CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.20859992
81MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.19851649
82RARB_27405468_Chip-Seq_BRAIN_Mouse1.19178602
83EZH2_27304074_Chip-Seq_ESCs_Mouse1.18299611
84CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.18098883
85SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.17645660
86TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17301671
87RNF2_27304074_Chip-Seq_NSC_Mouse1.16697521
88ERG_21242973_ChIP-ChIP_JURKAT_Human1.15472210
89CTCF_20526341_ChIP-Seq_ESCs_Human1.15062401
90ZNF274_21170338_ChIP-Seq_K562_Hela1.14836314
91MTF2_20144788_ChIP-Seq_MESCs_Mouse1.14371911
92TAF2_19829295_ChIP-Seq_ESCs_Human1.13915370
93TP53_20018659_ChIP-ChIP_R1E_Mouse1.12978274
94FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.12960114
95EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.11538880
96P68_20966046_ChIP-Seq_HELA_Human1.11261137
97MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.10716255
98E2F1_20622854_ChIP-Seq_HELA_Human1.10610223
99RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.10186519
100* TTF2_22483619_ChIP-Seq_HELA_Human1.09613307
101ETV2_25802403_ChIP-Seq_MESCs_Mouse1.09173784
102CREB1_15753290_ChIP-ChIP_HEK293T_Human1.08665393
103CTBP1_25329375_ChIP-Seq_LNCAP_Human1.08475766
104CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08382836
105PHF8_20622854_ChIP-Seq_HELA_Human1.07656209
106ELF1_20517297_ChIP-Seq_JURKAT_Human1.07267874
107ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.06399211
108E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.06108320
109SA1_27219007_Chip-Seq_Bcells_Human1.05611499
110SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.04359565
111DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.04156344
112DROSHA_22980978_ChIP-Seq_HELA_Human1.03352412
113RNF2_18974828_ChIP-Seq_MESCs_Mouse1.03183612
114EZH2_18974828_ChIP-Seq_MESCs_Mouse1.03183612
115GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.02925435
116NANOG_20526341_ChIP-Seq_ESCs_Human1.02621493
117GBX2_23144817_ChIP-Seq_PC3_Human1.02191736
118CTCF_27219007_Chip-Seq_Bcells_Human1.02054813
119MYC_19079543_ChIP-ChIP_MESCs_Mouse1.01599630
120MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.01356420
121BCL6_27268052_Chip-Seq_Bcells_Human1.01293241
122IRF1_19129219_ChIP-ChIP_H3396_Human0.98718393
123GATA3_21878914_ChIP-Seq_MCF-7_Human0.98551921
124* FOXP1_21924763_ChIP-Seq_HESCs_Human0.97559177
125SOX2_16153702_ChIP-ChIP_HESCs_Human0.97318495
126* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.97315342
127CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.97219536
128SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.97167178
129CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.97140891
130SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.96745916
131EWS_26573619_Chip-Seq_HEK293_Human0.96671642
132GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.96428814
133CTBP2_25329375_ChIP-Seq_LNCAP_Human0.95754013
134MYC_19829295_ChIP-Seq_ESCs_Human0.95748083
135GATA1_19941827_ChIP-Seq_MEL_Mouse0.95090463
136BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.95014144
137FUS_26573619_Chip-Seq_HEK293_Human0.94052586
138GATA1_22383799_ChIP-Seq_G1ME_Mouse0.93453741
139* MYC_19030024_ChIP-ChIP_MESCs_Mouse0.92561036
140PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.91924506
141P53_21459846_ChIP-Seq_SAOS-2_Human0.91882469
142RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.89676116
143RING1B_27294783_Chip-Seq_ESCs_Mouse0.89597363
144POU5F1_16153702_ChIP-ChIP_HESCs_Human0.87104611
145OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.86274278
146MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.86202398

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.23328547
2MP0003787_abnormal_imprinting2.83263169
3MP0001984_abnormal_olfaction2.81229696
4MP0003136_yellow_coat_color2.80326564
5MP0008789_abnormal_olfactory_epithelium2.70221848
6MP0004859_abnormal_synaptic_plasticity2.62941773
7MP0009379_abnormal_foot_pigmentation2.60641746
8MP0006292_abnormal_olfactory_placode2.49146231
9MP0002638_abnormal_pupillary_reflex2.43602007
10MP0006276_abnormal_autonomic_nervous2.38391967
11MP0001968_abnormal_touch/_nociception2.27919718
12MP0003635_abnormal_synaptic_transmissio2.27038358
13MP0003123_paternal_imprinting2.21450699
14MP0005646_abnormal_pituitary_gland2.19076038
15MP0005645_abnormal_hypothalamus_physiol2.16274568
16MP0002909_abnormal_adrenal_gland2.14468577
17MP0000778_abnormal_nervous_system2.14246796
18MP0000566_synostosis2.05491276
19MP0003121_genomic_imprinting2.04343947
20MP0008877_abnormal_DNA_methylation2.02049784
21MP0002736_abnormal_nociception_after2.01658770
22MP0009745_abnormal_behavioral_response2.01116865
23MP0005379_endocrine/exocrine_gland_phen1.91136142
24MP0005551_abnormal_eye_electrophysiolog1.82859434
25MP0002735_abnormal_chemical_nociception1.82495062
26MP0001502_abnormal_circadian_rhythm1.76564444
27MP0002572_abnormal_emotion/affect_behav1.76013240
28MP0010030_abnormal_orbit_morphology1.74754601
29MP0001501_abnormal_sleep_pattern1.71571549
30MP0005365_abnormal_bile_salt1.69447040
31MP0002064_seizures1.67988428
32MP0010386_abnormal_urinary_bladder1.66627335
33MP0001485_abnormal_pinna_reflex1.65947547
34MP0005423_abnormal_somatic_nervous1.63977342
35MP0001986_abnormal_taste_sensitivity1.63333313
36MP0001188_hyperpigmentation1.63318634
37MP0002063_abnormal_learning/memory/cond1.62880713
38MP0002272_abnormal_nervous_system1.60656617
39MP0002822_catalepsy1.59569534
40MP0000049_abnormal_middle_ear1.58293978
41MP0003122_maternal_imprinting1.57685730
42MP0001293_anophthalmia1.55166215
43MP0004142_abnormal_muscle_tone1.54749468
44MP0002837_dystrophic_cardiac_calcinosis1.51084934
45MP0002557_abnormal_social/conspecific_i1.49193024
46MP0000026_abnormal_inner_ear1.46114201
47MP0005332_abnormal_amino_acid1.45463244
48MP0003879_abnormal_hair_cell1.45146401
49MP0001944_abnormal_pancreas_morphology1.43383485
50MP0004133_heterotaxia1.42834900
51MP0008875_abnormal_xenobiotic_pharmacok1.42113219
52MP0002938_white_spotting1.40547265
53MP0005377_hearing/vestibular/ear_phenot1.40328975
54MP0003878_abnormal_ear_physiology1.40328975
55MP0002733_abnormal_thermal_nociception1.40185392
56MP0005174_abnormal_tail_pigmentation1.39207261
57MP0002139_abnormal_hepatobiliary_system1.38016596
58MP0001486_abnormal_startle_reflex1.37188775
59MP0005220_abnormal_exocrine_pancreas1.35132660
60MP0002067_abnormal_sensory_capabilities1.33370058
61MP0001970_abnormal_pain_threshold1.31330033
62MP0002102_abnormal_ear_morphology1.29542498
63MP0006072_abnormal_retinal_apoptosis1.27912489
64MP0001440_abnormal_grooming_behavior1.27018462
65MP0009046_muscle_twitch1.25290884
66MP0003938_abnormal_ear_development1.25058432
67MP0006036_abnormal_mitochondrial_physio1.25025200
68MP0002163_abnormal_gland_morphology1.24636886
69MP0003183_abnormal_peptide_metabolism1.23553015
70MP0000678_abnormal_parathyroid_gland1.22679431
71MP0002752_abnormal_somatic_nervous1.21361078
72MP0005636_abnormal_mineral_homeostasis1.21274389
73MP0002693_abnormal_pancreas_physiology1.20844318
74MP0005195_abnormal_posterior_eye1.20417426
75MP0002653_abnormal_ependyma_morphology1.20229993
76MP0003866_abnormal_defecation1.20102533
77MP0002734_abnormal_mechanical_nocicepti1.19378589
78MP0008872_abnormal_physiological_respon1.19120146
79MP0001765_abnormal_ion_homeostasis1.18857852
80MP0002876_abnormal_thyroid_physiology1.16997930
81MP0002277_abnormal_respiratory_mucosa1.15808266
82MP0000013_abnormal_adipose_tissue1.15677909
83MP0005535_abnormal_body_temperature1.13657804
84MP0001529_abnormal_vocalization1.11689487
85MP0008569_lethality_at_weaning1.10315787
86MP0002234_abnormal_pharynx_morphology1.09728708
87MP0003763_abnormal_thymus_physiology1.08274210
88MP0004742_abnormal_vestibular_system1.07135798
89MP0003329_amyloid_beta_deposits1.03984513
90MP0002184_abnormal_innervation1.03171291
91MP0004019_abnormal_vitamin_homeostasis1.01241713
92MP0001963_abnormal_hearing_physiology1.01130599
93MP0001664_abnormal_digestion1.00005684
94MP0003011_delayed_dark_adaptation0.99785203
95MP0001905_abnormal_dopamine_level0.98721096
96MP0001764_abnormal_homeostasis0.98559671
97MP0005389_reproductive_system_phenotype0.98510270
98MP0000631_abnormal_neuroendocrine_gland0.98398384
99MP0005409_darkened_coat_color0.98390508
100MP0002928_abnormal_bile_duct0.98360309
101MP0005075_abnormal_melanosome_morpholog0.98306870
102MP0004270_analgesia0.98012349
103MP0002249_abnormal_larynx_morphology0.97501797
104MP0003638_abnormal_response/metabolism_0.96037871
105MP0004885_abnormal_endolymph0.95820316
106MP0002152_abnormal_brain_morphology0.94975553
107MP0008961_abnormal_basal_metabolism0.93760706
108MP0003186_abnormal_redox_activity0.93239656
109MP0003942_abnormal_urinary_system0.92881107
110MP0000681_abnormal_thyroid_gland0.92204458
111MP0005253_abnormal_eye_physiology0.91157416
112MP0008058_abnormal_DNA_repair0.89859798
113MP0005084_abnormal_gallbladder_morpholo0.89611842
114MP0005499_abnormal_olfactory_system0.89296586
115MP0005394_taste/olfaction_phenotype0.89296586
116MP0002229_neurodegeneration0.89181779
117MP0004043_abnormal_pH_regulation0.88968883
118MP0003755_abnormal_palate_morphology0.88395523
119MP0001324_abnormal_eye_pigmentation0.86952637
120MP0002233_abnormal_nose_morphology0.86642039
121MP0002069_abnormal_eating/drinking_beha0.86625677
122MP0001270_distended_abdomen0.85600632
123MP0009643_abnormal_urine_homeostasis0.84362001
124MP0005391_vision/eye_phenotype0.83885002
125MP0003861_abnormal_nervous_system0.83673430
126MP0005085_abnormal_gallbladder_physiolo0.83523993
127MP0002078_abnormal_glucose_homeostasis0.82800887
128MP0002210_abnormal_sex_determination0.82531707
129MP0003953_abnormal_hormone_level0.81900959
130MP0001919_abnormal_reproductive_system0.81879866
131MP0002282_abnormal_trachea_morphology0.81625401
132MP0003315_abnormal_perineum_morphology0.80506246
133MP0002882_abnormal_neuron_morphology0.79433883
134MP0005248_abnormal_Harderian_gland0.79023543
135MP0004811_abnormal_neuron_physiology0.76517616
136MP0003937_abnormal_limbs/digits/tail_de0.74260765
137MP0006035_abnormal_mitochondrial_morpho0.73689596
138MP0003693_abnormal_embryo_hatching0.73597353
139MP0005584_abnormal_enzyme/coenzyme_acti0.72800607
140MP0002066_abnormal_motor_capabilities/c0.72337527
141MP0002160_abnormal_reproductive_system0.72190562
142MP0000955_abnormal_spinal_cord0.71139394
143MP0000538_abnormal_urinary_bladder0.69837489

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)3.91789433
2Abnormal number of erythroid precursors (HP:0012131)3.84176236
3Nephronophthisis (HP:0000090)3.79468874
4Rib fusion (HP:0000902)3.56797682
5Type I transferrin isoform profile (HP:0003642)3.29340424
6Chronic hepatic failure (HP:0100626)3.18924569
7Thyroid-stimulating hormone excess (HP:0002925)3.14199833
8Septo-optic dysplasia (HP:0100842)2.98415821
9Abnormality of the renal medulla (HP:0100957)2.97519657
10Severe visual impairment (HP:0001141)2.96647157
11Sclerocornea (HP:0000647)2.89456868
12Absent rod-and cone-mediated responses on ERG (HP:0007688)2.88120495
13Decreased activity of mitochondrial respiratory chain (HP:0008972)2.85630459
14Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.85630459
15Focal motor seizures (HP:0011153)2.81375283
16Polyphagia (HP:0002591)2.80008909
17Aplastic anemia (HP:0001915)2.77686708
18Abnormal glycosylation (HP:0012345)2.75625895
19Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.75625895
20Abnormal protein N-linked glycosylation (HP:0012347)2.75625895
21Abnormal protein glycosylation (HP:0012346)2.75625895
22Abnormal respiratory motile cilium morphology (HP:0005938)2.75458141
23Abnormal respiratory epithelium morphology (HP:0012253)2.75458141
24Visual hallucinations (HP:0002367)2.73531941
25Hypothermia (HP:0002045)2.70237510
26Pancreatic fibrosis (HP:0100732)2.68026131
27Abnormal rod and cone electroretinograms (HP:0008323)2.63115759
28Hepatocellular necrosis (HP:0001404)2.62918201
29Mitochondrial inheritance (HP:0001427)2.62182271
30Abnormal ciliary motility (HP:0012262)2.60958095
31True hermaphroditism (HP:0010459)2.59826105
32Abnormality of aromatic amino acid family metabolism (HP:0004338)2.56403931
33Abnormal respiratory motile cilium physiology (HP:0012261)2.51156964
34Microvesicular hepatic steatosis (HP:0001414)2.50436336
35Anencephaly (HP:0002323)2.50127368
36Rhinitis (HP:0012384)2.48583660
37Chronic bronchitis (HP:0004469)2.48113875
383-Methylglutaconic aciduria (HP:0003535)2.47587139
39Postaxial foot polydactyly (HP:0001830)2.46492275
40Type II lissencephaly (HP:0007260)2.45490021
41Split foot (HP:0001839)2.43780708
42Late onset (HP:0003584)2.43199027
43Reduced antithrombin III activity (HP:0001976)2.41843794
44Decreased circulating renin level (HP:0003351)2.39168025
45Poor suck (HP:0002033)2.37901092
46Abnormal mitochondria in muscle tissue (HP:0008316)2.37565750
47Retinal dysplasia (HP:0007973)2.36680307
48Abnormality of renal resorption (HP:0011038)2.36308339
49Nephrogenic diabetes insipidus (HP:0009806)2.35586565
50Medial flaring of the eyebrow (HP:0010747)2.34090504
51Chronic sinusitis (HP:0011109)2.32842331
52Agitation (HP:0000713)2.32465226
53Tubular atrophy (HP:0000092)2.31780541
54Pancreatic cysts (HP:0001737)2.30861268
55Hepatic necrosis (HP:0002605)2.30499271
56Anophthalmia (HP:0000528)2.29257599
57Aplasia/Hypoplasia of the sacrum (HP:0008517)2.29157209
58Acute necrotizing encephalopathy (HP:0006965)2.28909723
59Occipital encephalocele (HP:0002085)2.28390810
60Genital tract atresia (HP:0001827)2.25543310
61Vaginal atresia (HP:0000148)2.24510483
62Aplasia/Hypoplasia of the tongue (HP:0010295)2.23528127
63Gait imbalance (HP:0002141)2.23025034
64Congenital hepatic fibrosis (HP:0002612)2.20881370
65Ketoacidosis (HP:0001993)2.19562546
66Congenital stationary night blindness (HP:0007642)2.19197598
67Cerebral edema (HP:0002181)2.18356888
68Increased CSF lactate (HP:0002490)2.18349100
69Congenital primary aphakia (HP:0007707)2.17292053
70Polydipsia (HP:0001959)2.17085420
71Abnormal drinking behavior (HP:0030082)2.17085420
72Acute encephalopathy (HP:0006846)2.17002425
73Preaxial hand polydactyly (HP:0001177)2.16906311
74Male pseudohermaphroditism (HP:0000037)2.16828221
75Abnormality of magnesium homeostasis (HP:0004921)2.15558141
76Postaxial hand polydactyly (HP:0001162)2.14629523
77Ragged-red muscle fibers (HP:0003200)2.14100987
78Macrocytic anemia (HP:0001972)2.13804947
79Abnormality of the heme biosynthetic pathway (HP:0010472)2.10083171
80Lactic acidosis (HP:0003128)2.09601536
81Adrenal hypoplasia (HP:0000835)2.08816600
82Renal Fanconi syndrome (HP:0001994)2.08801458
83Large eyes (HP:0001090)2.08195969
84Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.08091693
85Aplasia/Hypoplasia of the spleen (HP:0010451)2.07196025
86Hyperglycinuria (HP:0003108)2.06879104
87Abnormality of the labia minora (HP:0012880)2.01634164
88Pallor (HP:0000980)2.01585274
89Cystic liver disease (HP:0006706)2.01250675
90Increased intramyocellular lipid droplets (HP:0012240)2.00154394
91Protruding tongue (HP:0010808)1.99711510
92Abnormality of macular pigmentation (HP:0008002)1.99702755
93Poikiloderma (HP:0001029)1.98979129
94Reticulocytopenia (HP:0001896)1.97910057
95Asplenia (HP:0001746)1.96272536
96Nasal polyposis (HP:0100582)1.92702484
97Optic nerve hypoplasia (HP:0000609)1.92622770
98Maternal diabetes (HP:0009800)1.92304298
99Pendular nystagmus (HP:0012043)1.91830243
100Poor coordination (HP:0002370)1.90743223
101Pachygyria (HP:0001302)1.90395584
102Increased muscle lipid content (HP:0009058)1.89283732
103Thrombocytosis (HP:0001894)1.88454143
104Limb dystonia (HP:0002451)1.87639049
105Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.87592420
106Abnormality of the renal cortex (HP:0011035)1.87567154
107Gout (HP:0001997)1.85720197
108Optic nerve coloboma (HP:0000588)1.85094974
109Hyperglycinemia (HP:0002154)1.85009474
110Median cleft lip (HP:0000161)1.84964879
111Dynein arm defect of respiratory motile cilia (HP:0012255)1.84292465
112Absent/shortened dynein arms (HP:0200106)1.84292465
113Exercise intolerance (HP:0003546)1.82454131
114Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.82453082
115Abnormality of urine glucose concentration (HP:0011016)1.82104563
116Glycosuria (HP:0003076)1.82104563
117Bony spicule pigmentary retinopathy (HP:0007737)1.81814622
118Psychosis (HP:0000709)1.81607346
119Abnormal biliary tract physiology (HP:0012439)1.81330992
120Bile duct proliferation (HP:0001408)1.81330992
121Ketosis (HP:0001946)1.80854789
122Abolished electroretinogram (ERG) (HP:0000550)1.80828844
123Retinitis pigmentosa (HP:0000510)1.80703151
124Optic disc pallor (HP:0000543)1.80490302
125Cerebral palsy (HP:0100021)1.79796063
126Hyperactive renin-angiotensin system (HP:0000841)1.79641343
127Anxiety (HP:0000739)1.79561793
128Oral leukoplakia (HP:0002745)1.79507064
129Narrow forehead (HP:0000341)1.79010327
130Exertional dyspnea (HP:0002875)1.78280380
131Progressive macrocephaly (HP:0004481)1.78004175
132Molar tooth sign on MRI (HP:0002419)1.77405206
133Abnormality of midbrain morphology (HP:0002418)1.77405206
134Increased serum lactate (HP:0002151)1.76177049
135Lipid accumulation in hepatocytes (HP:0006561)1.74778049
136Increased hepatocellular lipid droplets (HP:0006565)1.73352784
137Bronchiectasis (HP:0002110)1.73035782
138IgM deficiency (HP:0002850)1.72670242
139Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.72658436
140Abnormality of the aortic arch (HP:0012303)1.72418103
141Lissencephaly (HP:0001339)1.72416264
142Panhypogammaglobulinemia (HP:0003139)1.71638261
143Tubulointerstitial nephritis (HP:0001970)1.71152445
144Holoprosencephaly (HP:0001360)1.70782486
145Status epilepticus (HP:0002133)1.70641878
146Prolonged bleeding time (HP:0003010)1.70347924
147Aganglionic megacolon (HP:0002251)1.70325995
148Decreased central vision (HP:0007663)1.68747232
149Multicystic kidney dysplasia (HP:0000003)1.68457960
150Hyperphosphaturia (HP:0003109)1.68023701
151Abnormality of secondary sexual hair (HP:0009888)1.67419396
152Abnormality of the axillary hair (HP:0100134)1.67419396
153Myokymia (HP:0002411)1.66315492

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK4.58553865
2PINK13.92843825
3STK163.15255261
4MAPK152.78216410
5TAOK22.49000045
6DYRK22.45176079
7DAPK22.43648725
8CDK192.39923644
9MAP3K122.34514949
10DAPK12.31853331
11EPHB22.08127235
12MAP2K71.97230060
13BCKDK1.97076899
14MAP4K21.90759078
15NTRK31.90057411
16STK391.80699684
17MUSK1.80473150
18VRK21.80438539
19MAP2K61.71473882
20EPHA41.69561432
21PNCK1.63780651
22CAMK11.63288206
23ZAK1.56159335
24FES1.55710276
25NME21.46301092
26ARAF1.45100738
27DYRK31.35702817
28INSRR1.34568877
29MAPK71.33411397
30NME11.30517139
31NTRK21.30496765
32CDK31.29671113
33NUAK11.28882833
34BTK1.27656558
35LIMK11.25693800
36MAPKAPK31.24800552
37FLT31.17777851
38MINK11.16935848
39KIT1.16555379
40TNK21.15930803
41MAP3K111.13682841
42SIK21.12354570
43ERN11.12018310
44MAPK131.10791961
45PASK1.08149107
46BCR1.08104366
47DYRK1B1.06781234
48VRK11.05066195
49CSNK1G11.03394396
50MAP2K41.02654396
51CAMKK21.01418674
52FRK1.00012109
53MAP3K60.98493278
54MAPKAPK50.98058418
55CASK0.94363591
56RPS6KC10.92976577
57RPS6KL10.92976577
58PAK30.90672530
59MAP4K10.90639709
60WEE10.90522160
61RPS6KA60.89897161
62PRPF4B0.85996530
63HIPK20.85982286
64CSNK1A1L0.85611184
65IRAK20.83919173
66EIF2AK30.81093604
67ADRBK10.79678745
68CCNB10.78793126
69ABL20.77436847
70GRK10.77417386
71PHKG20.77276916
72PHKG10.77276916
73STK110.77246889
74BRAF0.76785553
75SYK0.73862449
76GRK60.72290172
77TAOK30.71957356
78SRPK10.71435345
79RIPK40.70901906
80PRKCG0.70818929
81ADRBK20.70418447
82MAP3K40.70288177
83NLK0.69497081
84TRIM280.67952536
85LRRK20.65981088
86TSSK60.65913779
87WNK30.62490011
88EEF2K0.62422291
89PRKCZ0.60144450
90BMPR1B0.59882280
91CDK80.59454813
92FGFR20.59375557
93ZAP700.59363088
94SGK2230.58617676
95SGK4940.58617676
96PLK10.58084716
97PRKACA0.57693156
98PRKCQ0.57145738
99PIK3CA0.56694865
100TYRO30.56656905
101WNK10.56344254
102TLK10.56128964
103MAP3K70.56090469
104OXSR10.55736442
105MARK10.54781629
106TGFBR10.54604915
107DYRK1A0.53877964
108DAPK30.53083871
109CSNK1A10.52963959
110RPS6KA50.52085110
111MYLK0.52064414
112PRKD30.51937970
113MARK20.50874131
114TEC0.50448924
115CDK50.49161373
116CAMK2B0.49073327
117PRKD20.48855845
118CAMK2D0.48179063
119RPS6KA20.48151708
120AURKA0.47822454
121YES10.47388255
122PRKCE0.46799400
123CSNK1E0.46528848
124CDC70.45351972
125PRKCI0.45061464
126PIM20.44861480
127RPS6KA40.43929874
128IRAK10.43312028
129PKN10.42987518
130SIK30.42199030
131CAMK40.41752937
132CSNK1G20.41434236
133CAMK2G0.40769116
134NEK20.40714108
135CSNK2A20.40689179
136CAMK2A0.40387708
137MAP3K130.39563055
138MATK0.39477144
139LYN0.39240764
140CDK140.38996504
141TIE10.38043363
142DMPK0.37493646
143CSNK1G30.35921581
144WNK40.34226633

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.13724653
2Maturity onset diabetes of the young_Homo sapiens_hsa049502.77472402
3Nicotine addiction_Homo sapiens_hsa050332.74840824
4Oxidative phosphorylation_Homo sapiens_hsa001902.62333373
5Protein export_Homo sapiens_hsa030602.40498129
6Parkinsons disease_Homo sapiens_hsa050122.34279911
7Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.03964431
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.02198816
9DNA replication_Homo sapiens_hsa030302.00752827
10N-Glycan biosynthesis_Homo sapiens_hsa005101.99607426
11Olfactory transduction_Homo sapiens_hsa047401.98065445
12Synaptic vesicle cycle_Homo sapiens_hsa047211.95685632
13Pyrimidine metabolism_Homo sapiens_hsa002401.82139460
14Huntingtons disease_Homo sapiens_hsa050161.80138288
15Sulfur relay system_Homo sapiens_hsa041221.79800622
16Insulin secretion_Homo sapiens_hsa049111.72364275
17Alzheimers disease_Homo sapiens_hsa050101.70082140
18Phototransduction_Homo sapiens_hsa047441.68533274
19Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.67482379
20Mismatch repair_Homo sapiens_hsa034301.66920510
21Taste transduction_Homo sapiens_hsa047421.66605292
22RNA polymerase_Homo sapiens_hsa030201.63886630
23GABAergic synapse_Homo sapiens_hsa047271.63093722
24Amphetamine addiction_Homo sapiens_hsa050311.61891347
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.60955070
26Steroid biosynthesis_Homo sapiens_hsa001001.59453987
27Cocaine addiction_Homo sapiens_hsa050301.58016994
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.57238958
29Circadian entrainment_Homo sapiens_hsa047131.56148980
30Morphine addiction_Homo sapiens_hsa050321.47065880
31Basal cell carcinoma_Homo sapiens_hsa052171.38080390
32Cyanoamino acid metabolism_Homo sapiens_hsa004601.37022111
33Glutamatergic synapse_Homo sapiens_hsa047241.32320018
34Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.31312337
35Collecting duct acid secretion_Homo sapiens_hsa049661.29110273
36Basal transcription factors_Homo sapiens_hsa030221.28021309
37Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.26005786
38Long-term potentiation_Homo sapiens_hsa047201.25363942
39Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.25296428
40Fanconi anemia pathway_Homo sapiens_hsa034601.23312026
41Hedgehog signaling pathway_Homo sapiens_hsa043401.22493790
42Drug metabolism - other enzymes_Homo sapiens_hsa009831.22478688
43Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.19511119
44Folate biosynthesis_Homo sapiens_hsa007901.18510892
45Pentose and glucuronate interconversions_Homo sapiens_hsa000401.17164832
46Linoleic acid metabolism_Homo sapiens_hsa005911.16878494
47Purine metabolism_Homo sapiens_hsa002301.14397022
48Dopaminergic synapse_Homo sapiens_hsa047281.13239654
49Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.12952230
50Aldosterone synthesis and secretion_Homo sapiens_hsa049251.11113186
51Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.10783716
52alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.08808833
53SNARE interactions in vesicular transport_Homo sapiens_hsa041301.08685530
54Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.08470175
55Other glycan degradation_Homo sapiens_hsa005111.06513702
56Homologous recombination_Homo sapiens_hsa034401.05816509
57Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.04691920
58Sulfur metabolism_Homo sapiens_hsa009201.01942864
59Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.99077537
60Base excision repair_Homo sapiens_hsa034100.98583586
61RNA degradation_Homo sapiens_hsa030180.96155487
62Nucleotide excision repair_Homo sapiens_hsa034200.95933733
63Calcium signaling pathway_Homo sapiens_hsa040200.95498753
64Serotonergic synapse_Homo sapiens_hsa047260.93732510
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.93127077
66Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.93051991
67Peroxisome_Homo sapiens_hsa041460.92506701
68Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.91418858
69ABC transporters_Homo sapiens_hsa020100.89673384
70Chemical carcinogenesis_Homo sapiens_hsa052040.87830648
71Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.87499778
72Cysteine and methionine metabolism_Homo sapiens_hsa002700.85805143
73Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.85712065
74Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.85398709
75Axon guidance_Homo sapiens_hsa043600.84337978
76Cardiac muscle contraction_Homo sapiens_hsa042600.83200271
77Primary bile acid biosynthesis_Homo sapiens_hsa001200.83006235
78Propanoate metabolism_Homo sapiens_hsa006400.82874259
79Cholinergic synapse_Homo sapiens_hsa047250.81983247
80Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.81600589
81Metabolic pathways_Homo sapiens_hsa011000.79200273
82Vibrio cholerae infection_Homo sapiens_hsa051100.78598027
83One carbon pool by folate_Homo sapiens_hsa006700.72726152
84Non-homologous end-joining_Homo sapiens_hsa034500.71797334
85Pyruvate metabolism_Homo sapiens_hsa006200.71583730
86Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.71507219
87Galactose metabolism_Homo sapiens_hsa000520.70968026
88Spliceosome_Homo sapiens_hsa030400.68795344
89Selenocompound metabolism_Homo sapiens_hsa004500.68715473
90Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.68479502
91Hippo signaling pathway_Homo sapiens_hsa043900.68171029
92Notch signaling pathway_Homo sapiens_hsa043300.67715727
93Salivary secretion_Homo sapiens_hsa049700.67495930
94Ether lipid metabolism_Homo sapiens_hsa005650.65450424
95Gastric acid secretion_Homo sapiens_hsa049710.61637464
96Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.60727839
97Glutathione metabolism_Homo sapiens_hsa004800.60165706
98Proteasome_Homo sapiens_hsa030500.59991639
99Nitrogen metabolism_Homo sapiens_hsa009100.58165397
100Tyrosine metabolism_Homo sapiens_hsa003500.58149218
101Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.57703640
102Fructose and mannose metabolism_Homo sapiens_hsa000510.54419567
103Primary immunodeficiency_Homo sapiens_hsa053400.54081414
104Circadian rhythm_Homo sapiens_hsa047100.54050776
105Glycosaminoglycan degradation_Homo sapiens_hsa005310.53807167
106Thyroid hormone synthesis_Homo sapiens_hsa049180.51244383
107Steroid hormone biosynthesis_Homo sapiens_hsa001400.50490292
108Oxytocin signaling pathway_Homo sapiens_hsa049210.50141224
109Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.48328985
110Retinol metabolism_Homo sapiens_hsa008300.47204445
111Alcoholism_Homo sapiens_hsa050340.46762984
112GnRH signaling pathway_Homo sapiens_hsa049120.45391536
113cAMP signaling pathway_Homo sapiens_hsa040240.44508108
114Renin secretion_Homo sapiens_hsa049240.44343500
115Tryptophan metabolism_Homo sapiens_hsa003800.44028778
116Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.43946859
117Fatty acid elongation_Homo sapiens_hsa000620.43904826
118Long-term depression_Homo sapiens_hsa047300.43648317
119Fatty acid degradation_Homo sapiens_hsa000710.43307023
120Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.42070068
121Regulation of autophagy_Homo sapiens_hsa041400.40761038
122Type I diabetes mellitus_Homo sapiens_hsa049400.38748429
123Arachidonic acid metabolism_Homo sapiens_hsa005900.38650666
124Pancreatic secretion_Homo sapiens_hsa049720.38613457
125Carbohydrate digestion and absorption_Homo sapiens_hsa049730.36869525
126Fat digestion and absorption_Homo sapiens_hsa049750.35056195
127Butanoate metabolism_Homo sapiens_hsa006500.34675800
128Glycerophospholipid metabolism_Homo sapiens_hsa005640.34544928
129Glucagon signaling pathway_Homo sapiens_hsa049220.34437909
130Arginine and proline metabolism_Homo sapiens_hsa003300.34294983
131beta-Alanine metabolism_Homo sapiens_hsa004100.34016818
132Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.33617277
133Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.32603944
134Wnt signaling pathway_Homo sapiens_hsa043100.30794591
135Ovarian steroidogenesis_Homo sapiens_hsa049130.30071843
136Phenylalanine metabolism_Homo sapiens_hsa003600.26565874
137Caffeine metabolism_Homo sapiens_hsa002320.25972434

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