DAO

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the peroxisomal enzyme D-amino acid oxidase. The enzyme is a flavoprotein which uses flavin adenine dinucleotide (FAD) as its prosthetic group. Its substrates include a wide variety of D-amino acids, but it is inactive on the naturally occurring L-amino acids. Its biological function is not known; it may act as a detoxifying agent which removes D-amino acids that accumulate during aging. In mice, it degrades D-serine, a co-agonist of the NMDA receptor. This gene may play a role in the pathophysiology of schizophrenia. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1drug transport (GO:0015893)9.04444782
2organic cation transport (GO:0015695)8.85608315
3phosphate ion transport (GO:0006817)8.39543915
4lysine metabolic process (GO:0006553)8.19490549
5lysine catabolic process (GO:0006554)8.19490549
6regulation of fibrinolysis (GO:0051917)7.77001566
7epoxygenase P450 pathway (GO:0019373)7.66882133
8negative regulation of fibrinolysis (GO:0051918)7.49381249
9omega-hydroxylase P450 pathway (GO:0097267)7.18451867
10exogenous drug catabolic process (GO:0042738)7.14097031
11quaternary ammonium group transport (GO:0015697)7.13482471
12drug catabolic process (GO:0042737)6.98901384
13phosphate ion transmembrane transport (GO:0035435)6.87714615
14complement activation, alternative pathway (GO:0006957)6.78336148
15regulation of protein activation cascade (GO:2000257)6.68238804
16cysteine metabolic process (GO:0006534)6.56366828
17urea metabolic process (GO:0019627)6.50328002
18nonribosomal peptide biosynthetic process (GO:0019184)6.47177462
19peptidyl-glutamic acid carboxylation (GO:0017187)6.22851620
20protein carboxylation (GO:0018214)6.22851620
21response to mercury ion (GO:0046689)6.20866479
22ethanol oxidation (GO:0006069)6.19671143
23regulation of complement activation (GO:0030449)6.18504652
24fibrinolysis (GO:0042730)6.16019851
25oxidative demethylation (GO:0070989)6.09097317
26tricarboxylic acid metabolic process (GO:0072350)6.07842429
27nitrogen cycle metabolic process (GO:0071941)5.95162094
28excretion (GO:0007588)5.90830411
29glutathione biosynthetic process (GO:0006750)5.83659002
30blood coagulation, intrinsic pathway (GO:0007597)5.77953267
31bile acid biosynthetic process (GO:0006699)5.76663665
32phenylpropanoid metabolic process (GO:0009698)5.68465574
33toxin transport (GO:1901998)5.64273052
34urea cycle (GO:0000050)5.60411415
35negative regulation of sterol transport (GO:0032372)5.57008603
36negative regulation of cholesterol transport (GO:0032375)5.57008603
37renal absorption (GO:0070293)5.55972812
38cellular glucuronidation (GO:0052695)5.55844240
39aspartate family amino acid catabolic process (GO:0009068)5.50288561
40short-chain fatty acid metabolic process (GO:0046459)5.40358567
41vitamin D metabolic process (GO:0042359)5.38283242
42trivalent inorganic anion homeostasis (GO:0072506)5.29679778
43phosphate ion homeostasis (GO:0055062)5.29679778
44glucuronate metabolic process (GO:0019585)5.28006182
45uronic acid metabolic process (GO:0006063)5.28006182
46* serine family amino acid catabolic process (GO:0009071)5.19310241
47amino-acid betaine transport (GO:0015838)5.14102605
48carnitine transport (GO:0015879)5.14102605
49regulation of triglyceride catabolic process (GO:0010896)5.13027444
50bile acid metabolic process (GO:0008206)5.13000699
51metanephric nephron tubule development (GO:0072234)5.07226790
52metanephric tubule development (GO:0072170)5.07226790
53glycine metabolic process (GO:0006544)5.05286484
54triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.99909138
55ethanol metabolic process (GO:0006067)4.94308881
56fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.86478334
57bile acid and bile salt transport (GO:0015721)4.77979879
58L-phenylalanine metabolic process (GO:0006558)4.76491599
59erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.76491599
60regulation of plasminogen activation (GO:0010755)4.76066249
61tryptophan catabolic process (GO:0006569)4.73415914
62indole-containing compound catabolic process (GO:0042436)4.73415914
63indolalkylamine catabolic process (GO:0046218)4.73415914
64valine metabolic process (GO:0006573)4.71624775
65cellular modified amino acid catabolic process (GO:0042219)4.70478881
66glycoside metabolic process (GO:0016137)4.67911391
67modified amino acid transport (GO:0072337)4.67173515
68aromatic amino acid family catabolic process (GO:0009074)4.65849366
69peptide biosynthetic process (GO:0043043)4.65665941
70alkaloid metabolic process (GO:0009820)4.65096435
71metanephric nephron epithelium development (GO:0072243)4.64101412
72homocysteine metabolic process (GO:0050667)4.62099405
73triglyceride homeostasis (GO:0070328)4.60273973
74acylglycerol homeostasis (GO:0055090)4.60273973
75negative regulation of blood coagulation (GO:0030195)4.55753748
76negative regulation of hemostasis (GO:1900047)4.55753748
77fructose metabolic process (GO:0006000)4.50998387
78erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.49240711
79L-phenylalanine catabolic process (GO:0006559)4.49240711
80protein activation cascade (GO:0072376)4.45671274
81tryptophan metabolic process (GO:0006568)4.44223874
82amino-acid betaine metabolic process (GO:0006577)4.39172758
832-oxoglutarate metabolic process (GO:0006103)4.38824670
84fatty acid beta-oxidation (GO:0006635)4.32460444
85metanephric epithelium development (GO:0072207)4.27374950
86phospholipid efflux (GO:0033700)4.26901354
87imidazole-containing compound metabolic process (GO:0052803)4.25491471
88S-adenosylmethionine metabolic process (GO:0046500)4.25041747
89oligosaccharide catabolic process (GO:0009313)4.24115620
90branched-chain amino acid catabolic process (GO:0009083)4.21753175
91peptide catabolic process (GO:0043171)4.20894319
92protein-lipid complex remodeling (GO:0034368)4.15192619
93macromolecular complex remodeling (GO:0034367)4.15192619
94plasma lipoprotein particle remodeling (GO:0034369)4.15192619
95nephron tubule development (GO:0072080)4.10390704
96negative regulation of coagulation (GO:0050819)4.09268735
97complement activation (GO:0006956)4.08873139
98tyrosine metabolic process (GO:0006570)4.07630284
99* branched-chain amino acid metabolic process (GO:0009081)4.07570501
100negative regulation of wound healing (GO:0061045)4.06858549
101carnitine metabolic process (GO:0009437)4.06541463
102high-density lipoprotein particle remodeling (GO:0034375)4.06330429
103steroid catabolic process (GO:0006706)4.06292460
104acetyl-CoA metabolic process (GO:0006084)4.00397039
105regulation of cholesterol esterification (GO:0010872)3.99671862
106complement activation, classical pathway (GO:0006958)3.96996628
107fatty acid oxidation (GO:0019395)3.96748660
108glutathione metabolic process (GO:0006749)3.94600276
109cholesterol efflux (GO:0033344)3.90792276
110response to phenylpropanoid (GO:0080184)3.90788051
111positive regulation of triglyceride lipase activity (GO:0061365)3.90444505
112positive regulation of lipoprotein lipase activity (GO:0051006)3.90444505
113lipid oxidation (GO:0034440)3.90357022
114negative regulation of lipase activity (GO:0060192)3.89645124
115sodium-independent organic anion transport (GO:0043252)3.88569722
116arginine metabolic process (GO:0006525)3.86718698
117hormone catabolic process (GO:0042447)3.86714978
118glutamate metabolic process (GO:0006536)3.84492330
119cellular ketone body metabolic process (GO:0046950)3.83841562
120regulation of humoral immune response (GO:0002920)3.83566630
121sulfur amino acid catabolic process (GO:0000098)3.82814259
122vitamin transport (GO:0051180)3.82347789
123NADH metabolic process (GO:0006734)3.79775637
124positive regulation of hemostasis (GO:1900048)3.78833411
125positive regulation of blood coagulation (GO:0030194)3.78833411
126negative regulation of protein activation cascade (GO:2000258)3.77937920
127acute-phase response (GO:0006953)3.77829782
128response to parathyroid hormone (GO:0071107)3.76909382
129reverse cholesterol transport (GO:0043691)3.74567035
130indole-containing compound metabolic process (GO:0042430)3.73980728
131serine family amino acid biosynthetic process (GO:0009070)3.66064952
132response to growth hormone (GO:0060416)3.63233594
133heme transport (GO:0015886)3.63164820
134renal tubule development (GO:0061326)3.61620408
135glutathione derivative biosynthetic process (GO:1901687)3.60294684
136glutathione derivative metabolic process (GO:1901685)3.60294684
137sulfur compound transport (GO:0072348)3.59130107
138* serine family amino acid metabolic process (GO:0009069)3.59040808
139fat-soluble vitamin biosynthetic process (GO:0042362)3.58999698
140beta-amyloid metabolic process (GO:0050435)3.56660965
141aldehyde catabolic process (GO:0046185)3.52460416
142* cellular amino acid catabolic process (GO:0009063)3.52100122
143fatty acid catabolic process (GO:0009062)3.50973960
144positive regulation of coagulation (GO:0050820)3.47667725
145aromatic amino acid family metabolic process (GO:0009072)3.47085074
146polyol transport (GO:0015791)3.44221647
147biotin metabolic process (GO:0006768)3.42919040
148regulation of lipoprotein particle clearance (GO:0010984)3.41606295
149* proline metabolic process (GO:0006560)3.39841471
150kynurenine metabolic process (GO:0070189)3.39170976
151flavonoid metabolic process (GO:0009812)3.38443507
152xenobiotic metabolic process (GO:0006805)3.35624812
153negative regulation of complement activation (GO:0045916)3.35145559
154nephron epithelium morphogenesis (GO:0072088)3.35087366
155nephron tubule morphogenesis (GO:0072078)3.35087366
156sodium ion transport (GO:0006814)3.34009376
157drug metabolic process (GO:0017144)3.32414409
158indolalkylamine metabolic process (GO:0006586)3.29333005
159monocarboxylic acid catabolic process (GO:0072329)3.27676654
160cytolysis (GO:0019835)3.27674416
161ketone body metabolic process (GO:1902224)3.27365068
162nephron epithelium development (GO:0072009)3.24536296
163* alpha-amino acid catabolic process (GO:1901606)3.24240848
164* organic acid catabolic process (GO:0016054)3.23588097
165* carboxylic acid catabolic process (GO:0046395)3.23588097
166opsonization (GO:0008228)3.23280441
167cofactor catabolic process (GO:0051187)3.22772625
168response to magnesium ion (GO:0032026)3.22302183
169L-ascorbic acid metabolic process (GO:0019852)3.22029836
170* glyoxylate metabolic process (GO:0046487)3.19847195
171very-low-density lipoprotein particle assembly (GO:0034379)3.19393166
172aminoglycoside antibiotic metabolic process (GO:0030647)10.9688013
173urate metabolic process (GO:0046415)10.6940644
174drug transmembrane transport (GO:0006855)10.6911779

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.75557653
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.73316296
3PPARA_22158963_ChIP-Seq_LIVER_Mouse3.89157711
4ESR1_21235772_ChIP-Seq_MCF-7_Human3.48717742
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.44898770
6LXR_22158963_ChIP-Seq_LIVER_Mouse3.33877214
7NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.24406743
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.05449801
9CDX2_20551321_ChIP-Seq_CACO-2_Human2.77154850
10ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.74850451
11TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.35698924
12ESR2_21235772_ChIP-Seq_MCF-7_Human2.31081409
13MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.24342452
14HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.20499257
15PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.13707165
16RARG_19884340_ChIP-ChIP_MEFs_Mouse2.12517260
17NR0B1_18358816_ChIP-ChIP_MESCs_Mouse2.12010712
18TRIM28_21343339_ChIP-Seq_HEK293_Human2.06113773
19NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.02139210
20* LXR_22292898_ChIP-Seq_THP-1_Human1.95148457
21TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.92775173
22GBX2_23144817_ChIP-Seq_PC3_Human1.87916600
23ERG_21242973_ChIP-ChIP_JURKAT_Human1.82417962
24HTT_18923047_ChIP-ChIP_STHdh_Human1.80656228
25TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.75648957
26CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.75597712
27VDR_22108803_ChIP-Seq_LS180_Human1.72976849
28AR_21909140_ChIP-Seq_LNCAP_Human1.69159076
29FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.69137601
30RACK7_27058665_Chip-Seq_MCF-7_Human1.63454707
31SOX2_27498859_Chip-Seq_STOMACH_Mouse1.56556251
32DROSHA_22980978_ChIP-Seq_HELA_Human1.55585567
33STAT3_1855785_ChIP-Seq_MESCs_Mouse1.51773082
34* HNF4A_19822575_ChIP-Seq_HepG2_Human1.49916980
35SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.44396342
36* REST_21632747_ChIP-Seq_MESCs_Mouse1.39976044
37EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.39119542
38BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.34997428
39ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.34212110
40SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.34031490
41GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.32975142
42SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.31921296
43NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.30465946
44REST_18959480_ChIP-ChIP_MESCs_Mouse1.27388222
45CLOCK_20551151_ChIP-Seq_293T_Human1.26377064
46FOXA2_19822575_ChIP-Seq_HepG2_Human1.24619069
47HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.23508184
48GATA4_25053715_ChIP-Seq_YYC3_Human1.22227515
49CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.22069487
50TET1_21451524_ChIP-Seq_MESCs_Mouse1.19619227
51ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.19452126
52RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.19155076
53ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.18728551
54E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.17181309
55SMAD3_21741376_ChIP-Seq_HESCs_Human1.16316747
56SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.15812199
57EGR1_19032775_ChIP-ChIP_M12_Human1.14451936
58CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.13633862
59PIAS1_25552417_ChIP-Seq_VCAP_Human1.12075948
60BCAT_22108803_ChIP-Seq_LS180_Human1.11015555
61SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.08805300
62GATA6_25053715_ChIP-Seq_YYC3_Human1.07992645
63ESR1_20079471_ChIP-ChIP_T-47D_Human1.07697949
64TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.05529926
65EZH2_27294783_Chip-Seq_ESCs_Mouse1.05239088
66STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.04671866
67SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.04146816
68IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.02294597
69TCF3_18692474_ChIP-Seq_MEFs_Mouse1.01121023
70RAC3_21632823_ChIP-Seq_H3396_Human1.00789005
71SMC4_20622854_ChIP-Seq_HELA_Human1.00258169
72PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.99003106
73CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.98808960
74DNAJC2_21179169_ChIP-ChIP_NT2_Human0.98718733
75NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.98366458
76EZH2_22144423_ChIP-Seq_EOC_Human0.96717667
77SUZ12_27294783_Chip-Seq_ESCs_Mouse0.96598076
78TBX20_22328084_ChIP-Seq_HEART_Mouse0.96426656
79TBX20_22080862_ChIP-Seq_HEART_Mouse0.96426656
80NANOG_18692474_ChIP-Seq_MEFs_Mouse0.96215057
81NANOG_16518401_ChIP-PET_MESCs_Mouse0.95510059
82AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.94773661
83ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.94706268
84RXR_22108803_ChIP-Seq_LS180_Human0.94343998
85EGR1_23403033_ChIP-Seq_LIVER_Mouse0.93423287
86RAD21_21589869_ChIP-Seq_MESCs_Mouse0.93338691
87TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.92379978
88ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.90333051
89CDX2_19796622_ChIP-Seq_MESCs_Mouse0.89964744
90* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.89537405
91EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.88842091
92SOX2_18692474_ChIP-Seq_MEFs_Mouse0.88618442
93POU5F1_16518401_ChIP-PET_MESCs_Mouse0.87573749
94P300_27058665_Chip-Seq_ZR-75-30cells_Human0.85462312
95RNF2_18974828_ChIP-Seq_MESCs_Mouse0.84489736
96EZH2_18974828_ChIP-Seq_MESCs_Mouse0.84489736
97CTCF_27219007_Chip-Seq_Bcells_Human0.83864812
98IGF1R_20145208_ChIP-Seq_DFB_Human0.83562217
99IRF1_19129219_ChIP-ChIP_H3396_Human0.83309130
100TP53_18474530_ChIP-ChIP_U2OS_Human0.82878290
101SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.82692163
102KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.82579838
103CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.82424662
104PPAR_26484153_Chip-Seq_NCI-H1993_Human0.82308937
105FOXO3_23340844_ChIP-Seq_DLD1_Human0.82246937
106POU3F2_20337985_ChIP-ChIP_501MEL_Human0.81587472
107CREB1_26743006_Chip-Seq_LNCaP_Human0.81540945
108RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.81320217
109RXRA_24833708_ChIP-Seq_LIVER_Mouse0.81176586
110TP63_22573176_ChIP-Seq_HFKS_Human0.81084944
111* P68_20966046_ChIP-Seq_HELA_Human0.80372360
112ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.80085201
113SOX2_21211035_ChIP-Seq_LN229_Human0.80024157
114WDR5_24793694_ChIP-Seq_LNCAP_Human0.79567738
115CTCF_21964334_ChIP-Seq_BJAB-B_Human0.79523034
116PHF8_20622853_ChIP-Seq_HELA_Human0.79244803
117FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.79155124
118* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.78976017
119NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.78946301
120GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.78446355
121MTF2_20144788_ChIP-Seq_MESCs_Mouse0.78373930
122SA1_27219007_Chip-Seq_Bcells_Human0.78289476
123CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.78130092
124SMAD4_21741376_ChIP-Seq_HESCs_Human0.77930431
125NANOG_18692474_ChIP-Seq_MESCs_Mouse0.77860594
126TAF15_26573619_Chip-Seq_HEK293_Human0.77806165
127PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.77625132
128RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.77517540
129NFE2_27457419_Chip-Seq_LIVER_Mouse0.76848450
130JARID2_20075857_ChIP-Seq_MESCs_Mouse0.76654932
131* ETV2_25802403_ChIP-Seq_MESCs_Mouse0.75896763
132CBP_21632823_ChIP-Seq_H3396_Human0.75765217
133NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.75491163
134TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.75272832
135BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.75238843
136SOX2_20726797_ChIP-Seq_SW620_Human0.74840432
137CTCF_27219007_Chip-Seq_ERYTHROID_Human0.74718022
138SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.74564993
139SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.74391197
140SMAD4_21799915_ChIP-Seq_A2780_Human0.74375271
141* KLF5_20875108_ChIP-Seq_MESCs_Mouse0.73986876
142EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.73885709
143SRY_22984422_ChIP-ChIP_TESTIS_Rat0.73861970
144THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.73503648
145CDX2_22108803_ChIP-Seq_LS180_Human0.73004671
146MYC_19915707_ChIP-ChIP_AK7_Human0.72992662
147GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.72277551
148SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.71714137
149STAT3_23295773_ChIP-Seq_U87_Human0.71606669
150HNFA_21074721_ChIP-Seq_CACO-2_Human0.71196428
151RARB_27405468_Chip-Seq_BRAIN_Mouse0.71102848
152* NFYA_21822215_ChIP-Seq_K562_Human0.71003690
153CTBP1_25329375_ChIP-Seq_LNCAP_Human0.70569682
154ESR1_15608294_ChIP-ChIP_MCF-7_Human0.70526790
155TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.70449507
156ER_23166858_ChIP-Seq_MCF-7_Human0.70224829
157SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.69518298
158AR_19668381_ChIP-Seq_PC3_Human0.67807779
159AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.67693217
160GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.67567050
161MYC_19829295_ChIP-Seq_ESCs_Human0.67363281
162JARID2_20064375_ChIP-Seq_MESCs_Mouse0.66770546
163CTCF_20526341_ChIP-Seq_ESCs_Human0.66630056
164EZH2_27294783_Chip-Seq_NPCs_Mouse0.66274691
165SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.66147539
166GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.65743232
167SUZ12_27294783_Chip-Seq_NPCs_Mouse0.65347232
168* NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.64902883
169TCF4_23295773_ChIP-Seq_U87_Human0.64794444
170KAP1_22055183_ChIP-Seq_ESCs_Mouse0.64583604

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis7.82304040
2MP0004043_abnormal_pH_regulation6.47061598
3MP0004019_abnormal_vitamin_homeostasis5.34517930
4MP0002139_abnormal_hepatobiliary_system4.82334234
5* MP0005332_abnormal_amino_acid4.71812610
6MP0009643_abnormal_urine_homeostasis3.89568738
7MP0002138_abnormal_hepatobiliary_system3.88178457
8MP0001765_abnormal_ion_homeostasis3.76733718
9MP0003868_abnormal_feces_composition3.64898954
10MP0003195_calcinosis3.58755595
11MP0005377_hearing/vestibular/ear_phenot3.11868357
12MP0003878_abnormal_ear_physiology3.11868357
13MP0005636_abnormal_mineral_homeostasis3.05995203
14MP0001756_abnormal_urination2.98395322
15MP0002136_abnormal_kidney_physiology2.90991590
16MP0009697_abnormal_copulation2.90601097
17MP0008875_abnormal_xenobiotic_pharmacok2.71884270
18MP0001958_emphysema2.56429950
19MP0005058_abnormal_lysosome_morphology2.40351446
20MP0003252_abnormal_bile_duct2.19245397
21MP0005365_abnormal_bile_salt2.18733003
22MP0005085_abnormal_gallbladder_physiolo2.12316899
23MP0004885_abnormal_endolymph2.03466995
24MP0009840_abnormal_foam_cell1.83758671
25MP0000538_abnormal_urinary_bladder1.82873707
26MP0003186_abnormal_redox_activity1.78907932
27MP0005423_abnormal_somatic_nervous1.64830465
28MP0005584_abnormal_enzyme/coenzyme_acti1.61174043
29MP0003880_abnormal_central_pattern1.57865826
30MP0003283_abnormal_digestive_organ1.49917143
31MP0008961_abnormal_basal_metabolism1.45479288
32MP0005084_abnormal_gallbladder_morpholo1.33208493
33MP0002876_abnormal_thyroid_physiology1.32851077
34MP0005319_abnormal_enzyme/_coenzyme1.32494643
35MP0004147_increased_porphyrin_level1.31765160
36MP0005670_abnormal_white_adipose1.30349449
37MP0002089_abnormal_postnatal_growth/wei1.27035723
38MP0005451_abnormal_body_composition1.26292704
39MP0003690_abnormal_glial_cell1.24426003
40MP0003172_abnormal_lysosome_physiology1.23240142
41MP0002928_abnormal_bile_duct1.22949656
42MP0002168_other_aberrant_phenotype1.22675994
43MP0006036_abnormal_mitochondrial_physio1.21173797
44MP0002064_seizures1.20515426
45MP0004859_abnormal_synaptic_plasticity1.13633064
46* MP0009745_abnormal_behavioral_response1.12385536
47MP0003300_gastrointestinal_ulcer1.08954484
48MP0002272_abnormal_nervous_system1.05621305
49MP0000604_amyloidosis1.03793087
50MP0001440_abnormal_grooming_behavior1.03707464
51MP0010368_abnormal_lymphatic_system1.03507224
52MP0002135_abnormal_kidney_morphology1.00417962
53MP0005535_abnormal_body_temperature0.99867210
54MP0000230_abnormal_systemic_arterial0.98036676
55MP0000371_diluted_coat_color0.96492025
56MP0005187_abnormal_penis_morphology0.95796352
57* MP0003635_abnormal_synaptic_transmissio0.94504603
58MP0008874_decreased_physiological_sensi0.93523464
59MP0003806_abnormal_nucleotide_metabolis0.92850651
60MP0004270_analgesia0.92536404
61MP0002735_abnormal_chemical_nociception0.92227396
62MP0002896_abnormal_bone_mineralization0.91874959
63MP0001666_abnormal_nutrient_absorption0.91813682
64MP0001764_abnormal_homeostasis0.91409547
65MP0004264_abnormal_extraembryonic_tissu0.90995275
66MP0003638_abnormal_response/metabolism_0.90020038
67MP0002063_abnormal_learning/memory/cond0.89619181
68MP0001485_abnormal_pinna_reflex0.88388662
69MP0005666_abnormal_adipose_tissue0.88201799
70MP0001501_abnormal_sleep_pattern0.87016427
71MP0002118_abnormal_lipid_homeostasis0.81178178
72MP0003191_abnormal_cellular_cholesterol0.78938300
73MP0005408_hypopigmentation0.78084044
74MP0004233_abnormal_muscle_weight0.77793908
75MP0003011_delayed_dark_adaptation0.76786446
76MP0002796_impaired_skin_barrier0.76369210
77MP0001486_abnormal_startle_reflex0.75913083
78MP0009046_muscle_twitch0.75428959
79MP0003646_muscle_fatigue0.75003069
80MP0004742_abnormal_vestibular_system0.73178665
81MP0001968_abnormal_touch/_nociception0.72358942
82MP0009764_decreased_sensitivity_to0.70202283
83MP0002572_abnormal_emotion/affect_behav0.69732713
84MP0005376_homeostasis/metabolism_phenot0.68720455
85MP0009053_abnormal_anal_canal0.67822552
86MP0001986_abnormal_taste_sensitivity0.67504287
87MP0001915_intracranial_hemorrhage0.66764399
88MP0005266_abnormal_metabolism0.66150677
89* MP0009642_abnormal_blood_homeostasis0.65807003
90MP0000747_muscle_weakness0.65516115
91MP0005395_other_phenotype0.65474243
92MP0000920_abnormal_myelination0.64219877
93MP0002736_abnormal_nociception_after0.63855887
94MP0002734_abnormal_mechanical_nocicepti0.62811517
95MP0003631_nervous_system_phenotype0.62370615
96MP0003656_abnormal_erythrocyte_physiolo0.61823005
97MP0001502_abnormal_circadian_rhythm0.61207300
98MP0002249_abnormal_larynx_morphology0.60769616
99MP0004130_abnormal_muscle_cell0.60400345
100MP0008569_lethality_at_weaning0.59641233
101MP0002282_abnormal_trachea_morphology0.59609884
102MP0001661_extended_life_span0.58339502
103MP0003879_abnormal_hair_cell0.57819635
104MP0005501_abnormal_skin_physiology0.56249541
105MP0003959_abnormal_lean_body0.55528506
106MP0003632_abnormal_nervous_system0.55142709
107MP0004142_abnormal_muscle_tone0.54719142
108MP0009763_increased_sensitivity_to0.54495918
109MP0002132_abnormal_respiratory_system0.54426464
110MP0002090_abnormal_vision0.53728804
111MP0002115_abnormal_skeleton_extremities0.51920961
112MP0000609_abnormal_liver_physiology0.51903697
113MP0005386_behavior/neurological_phenoty0.51253610
114MP0004924_abnormal_behavior0.51253610
115MP0001984_abnormal_olfaction0.50984884
116MP0000566_synostosis0.50860126
117MP0005220_abnormal_exocrine_pancreas0.49726602
118MP0003953_abnormal_hormone_level0.49464192
119MP0005551_abnormal_eye_electrophysiolog0.48534829
120MP0010329_abnormal_lipoprotein_level0.48268978
121MP0005448_abnormal_energy_balance0.47661757
122MP0002069_abnormal_eating/drinking_beha0.46646669
123MP0002998_abnormal_bone_remodeling0.46008229
124MP0005646_abnormal_pituitary_gland0.45814427
125MP0002332_abnormal_exercise_endurance0.45418633
126* MP0002066_abnormal_motor_capabilities/c0.45227218
127MP0002822_catalepsy0.44481609
128MP0000598_abnormal_liver_morphology0.44374628
129MP0001963_abnormal_hearing_physiology0.43635210
130MP0006035_abnormal_mitochondrial_morpho0.43006195
131MP0010386_abnormal_urinary_bladder0.42291315
132MP0000678_abnormal_parathyroid_gland0.41838817
133MP0002078_abnormal_glucose_homeostasis0.40858872
134MP0001731_abnormal_postnatal_growth0.40520631
135MP0008469_abnormal_protein_level0.39293139
136MP0005165_increased_susceptibility_to0.38591944
137MP0002098_abnormal_vibrissa_morphology0.38061885
138MP0003795_abnormal_bone_structure0.37990434
139MP0000163_abnormal_cartilage_morphology0.36943825
140MP0002067_abnormal_sensory_capabilities0.36418663
141MP0003329_amyloid_beta_deposits0.36160838
142MP0003633_abnormal_nervous_system0.35756459
143MP0001663_abnormal_digestive_system0.35621159
144MP0001293_anophthalmia0.35056742
145MP0002971_abnormal_brown_adipose0.32103736
146MP0009278_abnormal_bone_marrow0.31955929
147MP0005167_abnormal_blood-brain_barrier0.31816999
148MP0005375_adipose_tissue_phenotype0.30133261
149MP0004484_altered_response_of0.29003406
150MP0003075_altered_response_to0.28930608
151MP0000367_abnormal_coat/_hair0.28788656
152MP0008872_abnormal_physiological_respon0.26967362
153MP0005381_digestive/alimentary_phenotyp0.26559619
154MP0002075_abnormal_coat/hair_pigmentati0.26089918
155MP0004858_abnormal_nervous_system0.26005906

Predicted human phenotypes

RankGene SetZ-score
1Prolonged partial thromboplastin time (HP:0003645)8.66032820
2Complement deficiency (HP:0004431)7.94181817
3Increased circulating renin level (HP:0000848)7.54666785
4Hypobetalipoproteinemia (HP:0003563)7.35595179
5Metabolic alkalosis (HP:0200114)7.26059301
6Hypokalemic alkalosis (HP:0001949)7.09753593
7Gout (HP:0001997)6.91910506
8Hypomagnesemia (HP:0002917)6.82118842
9Polyuria (HP:0000103)6.64844106
10Hyperactive renin-angiotensin system (HP:0000841)6.59424278
11Abnormality of complement system (HP:0005339)6.24461354
12Abnormal urine output (HP:0012590)6.24391289
13Abnormality of chloride homeostasis (HP:0011422)6.14572103
14Abnormality of renal excretion (HP:0011036)6.00003950
15Hyperlipoproteinemia (HP:0010980)5.90927657
16Joint hemorrhage (HP:0005261)5.84132910
17Abnormality of magnesium homeostasis (HP:0004921)5.77171086
18Systemic lupus erythematosus (HP:0002725)5.55309721
19Abnormal drinking behavior (HP:0030082)5.40126163
20Polydipsia (HP:0001959)5.40126163
21Proximal tubulopathy (HP:0000114)5.38591127
22Conjugated hyperbilirubinemia (HP:0002908)5.33735239
23Increased purine levels (HP:0004368)5.10736800
24Hyperuricemia (HP:0002149)5.10736800
25Intrahepatic cholestasis (HP:0001406)5.01327613
26Abnormality of pyrimidine metabolism (HP:0004353)4.83410342
27Hyperglycinuria (HP:0003108)4.79456444
28Abnormality of glutamine family amino acid metabolism (HP:0010902)4.79268596
29Xanthomatosis (HP:0000991)4.76898264
30Renal salt wasting (HP:0000127)4.71222979
31Alkalosis (HP:0001948)4.68994306
32Abnormality of renin-angiotensin system (HP:0000847)4.67989577
33Tetany (HP:0001281)4.60239958
34Glomerulonephritis (HP:0000099)4.57776163
35Hyperaldosteronism (HP:0000859)4.57610493
36Abnormality of purine metabolism (HP:0004352)4.48532204
37Hypolipoproteinemia (HP:0010981)4.26859649
38Generalized aminoaciduria (HP:0002909)4.20671487
39Hypercalciuria (HP:0002150)4.18804911
40Abnormality of glycine metabolism (HP:0010895)3.83484009
41Abnormality of serine family amino acid metabolism (HP:0010894)3.83484009
42Abnormality of the common coagulation pathway (HP:0010990)3.79555282
43Ketoacidosis (HP:0001993)3.79108487
44Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.72631670
45Renal tubular acidosis (HP:0001947)3.65489498
46Abnormality of urine glucose concentration (HP:0011016)3.64634728
47Glycosuria (HP:0003076)3.64634728
48Hypokalemia (HP:0002900)3.59870332
49Recurrent gram-negative bacterial infections (HP:0005420)3.57268537
50Abnormality of the intrinsic pathway (HP:0010989)3.43576660
51Abnormality of nucleobase metabolism (HP:0010932)3.28843929
52Abnormality of proline metabolism (HP:0010907)3.21933524
53Hydroxyprolinuria (HP:0003080)3.21933524
54Ketosis (HP:0001946)3.21878439
55Hyperphosphaturia (HP:0003109)3.18101641
56Nephritis (HP:0000123)3.14929165
57Delayed epiphyseal ossification (HP:0002663)3.14487497
58Spontaneous abortion (HP:0005268)3.12264365
59Nephrocalcinosis (HP:0000121)3.06895320
60Fat malabsorption (HP:0002630)3.05289791
61Hypoalphalipoproteinemia (HP:0003233)3.04992356
62Abnormal urine phosphate concentration (HP:0012599)3.04968626
63Abnormality of potassium homeostasis (HP:0011042)3.01191287
64Osteomalacia (HP:0002749)2.97595454
65Cholecystitis (HP:0001082)2.84722548
66Abnormal gallbladder physiology (HP:0012438)2.84722548
67Nephrolithiasis (HP:0000787)2.82079676
68Vascular calcification (HP:0004934)2.78033156
69Metaphyseal cupping (HP:0003021)2.73261124
70Delayed CNS myelination (HP:0002188)2.72500261
71Hypophosphatemia (HP:0002148)2.72401949
72Reduced antithrombin III activity (HP:0001976)2.72377541
73Epidermoid cyst (HP:0200040)2.67984233
74Abnormality of aspartate family amino acid metabolism (HP:0010899)2.65701755
75Widely patent fontanelles and sutures (HP:0004492)2.62430796
76Hyperglycinemia (HP:0002154)2.62068281
77Rickets (HP:0002748)2.61897425
78Steatorrhea (HP:0002570)2.61079362
79Abnormality of methionine metabolism (HP:0010901)2.60547036
80Abnormality of fatty-acid metabolism (HP:0004359)2.58883371
81Hypercholesterolemia (HP:0003124)2.56710983
82Abnormality of serum amino acid levels (HP:0003112)2.53072080
83Fair hair (HP:0002286)2.52510815
84Vacuolated lymphocytes (HP:0001922)2.48936436
85Dehydration (HP:0001944)2.46917396
86Cardiovascular calcification (HP:0011915)2.44590082
87Abnormality of the Achilles tendon (HP:0005109)2.42371226
88Abnormality of sodium homeostasis (HP:0010931)2.40917415
89Menorrhagia (HP:0000132)2.37981669
90Purpura (HP:0000979)2.37053262
91Confusion (HP:0001289)2.36588519
92Pulmonary embolism (HP:0002204)2.36199912
93Hyponatremia (HP:0002902)2.36038758
94Abnormal enzyme/coenzyme activity (HP:0012379)2.35817792
95Hyperammonemia (HP:0001987)2.35632557
96Hemorrhage of the eye (HP:0011885)2.33237939
97Abnormality of alkaline phosphatase activity (HP:0004379)2.30627702
98Bilateral sensorineural hearing impairment (HP:0008619)2.30427849
99Mitral stenosis (HP:0001718)2.30350043
100Myokymia (HP:0002411)2.27412036
101Abnormality of dicarboxylic acid metabolism (HP:0010995)2.27176876
102Dicarboxylic aciduria (HP:0003215)2.27176876
103Malnutrition (HP:0004395)2.26835925
104Neonatal hypoglycemia (HP:0001998)2.24474857
105Vomiting (HP:0002013)2.20533504
106Metabolic acidosis (HP:0001942)2.20521875
107Abnormality of renal resorption (HP:0011038)2.20466652
108Gingival bleeding (HP:0000225)2.19107111
109Adrenal overactivity (HP:0002717)2.18063195
110Renal tubular dysfunction (HP:0000124)2.15908370
111Hyperbilirubinemia (HP:0002904)2.15553082
112Enlarged kidneys (HP:0000105)2.14273217
113Arthropathy (HP:0003040)2.09159646
114Cholelithiasis (HP:0001081)2.08403567
115Bile duct proliferation (HP:0001408)2.07635662
116Abnormal biliary tract physiology (HP:0012439)2.07635662
117Abnormal tarsal ossification (HP:0008369)2.06416329
118Thin bony cortex (HP:0002753)2.05816678
119Atrioventricular block (HP:0001678)2.03777710
120Methylmalonic aciduria (HP:0012120)2.02779259
121Abnormality of monocarboxylic acid metabolism (HP:0010996)10.2976122
122Deep venous thrombosis (HP:0002625)10.2556755
123Abnormality of sulfur amino acid metabolism (HP:0004339)1.99694146
124Thrombophlebitis (HP:0004418)1.99463139
125Abnormality of vitamin metabolism (HP:0100508)1.99333232
126Abnormality of aromatic amino acid family metabolism (HP:0004338)1.97958017
127Lethargy (HP:0001254)1.96996358
128Abnormal gallbladder morphology (HP:0012437)1.94922073
129Abnormality of the costochondral junction (HP:0000919)1.93067047
130Tubular atrophy (HP:0000092)1.90420966
131Status epilepticus (HP:0002133)1.90137263
132Morphological abnormality of the pyramidal tract (HP:0002062)1.87242864
133Dysostosis multiplex (HP:0000943)1.84407238
134Hepatocellular carcinoma (HP:0001402)1.83083148
135Mucopolysacchariduria (HP:0008155)1.81744079
136Urinary glycosaminoglycan excretion (HP:0003541)1.81744079
137Torticollis (HP:0000473)1.81562790
138Chondrocalcinosis (HP:0000934)1.80975289
139Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.79750064
140Potter facies (HP:0002009)1.78607893
141Facial shape deformation (HP:0011334)1.78607893
142Action tremor (HP:0002345)1.78201592
143Irritability (HP:0000737)1.77709176
144Decreased circulating renin level (HP:0003351)1.77159743
145Generalized hypopigmentation of hair (HP:0011358)1.75985173
146Tubulointerstitial fibrosis (HP:0005576)1.75464454
147Bicornuate uterus (HP:0000813)1.75017798
148Focal motor seizures (HP:0011153)1.74977520
149Metaphyseal irregularity (HP:0003025)1.74273110
150Lymphangioma (HP:0100764)1.74140533
151Elevated alkaline phosphatase (HP:0003155)1.70508229
152Abnormality of Sharpey fibers (HP:0100685)1.70465489
153Neonatal onset (HP:0003623)1.70057604
154Blue irides (HP:0000635)1.69707509
155Abnormality of mucopolysaccharide metabolism (HP:0011020)1.69391421
156Abnormality of polysaccharide metabolism (HP:0011012)1.69391421
157Abnormality of glycosaminoglycan metabolism (HP:0004371)1.69391421
158Nausea (HP:0002018)1.68963784
159Hypotension (HP:0002615)1.68606649
160Bifid scrotum (HP:0000048)1.68537148
161Abnormality of carpal bone ossification (HP:0006257)1.68069044
162Retinal atrophy (HP:0001105)1.64113054
163Abnormality of the lower motor neuron (HP:0002366)1.62961523
164Sensorimotor neuropathy (HP:0007141)1.62568026
165Skin nodule (HP:0200036)1.59360228
166Focal dystonia (HP:0004373)1.59187260
167Craniofacial dystonia (HP:0012179)1.56665351
168Febrile seizures (HP:0002373)1.56392542
169Cerebral edema (HP:0002181)1.52744130
170Myocardial infarction (HP:0001658)1.51737240
171Gangrene (HP:0100758)1.51634425

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK48.81857048
2WNK37.60062001
3OXSR17.11652779
4STK393.97080786
5NTRK33.82904193
6DAPK23.57709498
7MARK13.08867489
8BCKDK2.83837318
9EPHA42.70392741
10STK38L2.66128174
11WNK12.28039151
12CAMKK22.25212865
13PINK12.19381769
14PIK3CG1.99718181
15NTRK21.97795111
16NEK11.95768926
17SGK2231.93402441
18SGK4941.93402441
19CAMKK11.91337667
20MAP3K91.88294063
21PRPF4B1.84281346
22CASK1.74813589
23PDK31.67804756
24PDK41.67804756
25STK381.67514828
26PIK3CA1.61502250
27ARAF1.60849164
28PAK61.57655755
29MAP3K121.52474596
30MAPK151.41147727
31MAP3K41.40848920
32ERN11.28979471
33ICK1.22793722
34PDK21.21672439
35GRK51.17758828
36CAMK2B1.16968061
37SGK31.15711634
38DDR21.13923564
39MST1R1.12363423
40SGK21.09632193
41DYRK1B1.07136928
42GSK3A1.01526115
43MAP3K60.99321215
44DYRK1A0.94269990
45MST40.91995365
46MAP2K70.91941343
47MARK20.91223511
48FGFR20.88449432
49CDK50.87604912
50KSR20.87342042
51PRKD20.86877991
52MAP3K110.86414746
53RIPK10.85357138
54ERBB20.81215568
55CAMK2A0.81147413
56SGK10.81108512
57EPHB10.78770245
58FGFR40.73424589
59PRKG10.73106855
60LATS20.72629697
61PRKAA10.70313497
62CAMK2D0.69521929
63GRK60.68828324
64MAPK130.68765892
65MAPK110.67114547
66BMX0.65962862
67MATK0.65125650
68MUSK0.63290377
69CSNK1D0.60280509
70FRK0.60164801
71DAPK30.59129305
72PTK20.58869757
73LRRK20.58435022
74RET0.55617051
75RPS6KB10.55063601
76CSNK1A10.52817785
77CSNK1G20.52658900
78MAPK100.52658816
79SIK10.52019309
80CDK150.51579134
81PRKCB0.50180974
82CSK0.50171082
83IGF1R0.49602188
84PRKAA20.49049560
85TYRO30.48304618
86LMTK20.47877818
87PRKCE0.46964171
88CDK180.46301199
89DAPK10.45766600
90PIM10.45765921
91CAMK10.45276845
92MAP3K70.42527469
93PDGFRA0.41217022
94CDK140.40971760
95JAK10.40913828
96CDK11A0.38399197
97TAOK20.37747716
98PTK60.37688726
99FGFR30.37236534
100PKN10.36742430
101TIE10.36286720
102PAK40.36277282
103PRKCZ0.34316396
104PDPK10.33919034
105PRKCI0.30790606
106STK110.30403964
107MAP3K140.29530353
108FGR0.28173901
109PRKCD0.27129803
110UHMK10.25596245
111PRKACG0.25288572
112ABL20.24592284
113MAP3K30.24284940
114TGFBR20.23623556
115TRIB30.22371849
116PDK10.21634327
117PHKG20.21050179
118PHKG10.21050179
119YES10.20920855
120IRAK30.20730424
121IRAK20.18991075
122MINK10.18361103
123INSRR0.16310115
124CAMK2G0.15619947
125PRKCH0.15153737
126AKT20.15042613
127PRKCG0.14531381
128PRKACA0.14385472
129JAK20.14377958
130TRPM70.14146590
131PRKCA0.13621096
132CAMK40.13574521
133PIM20.11114388
134STK100.10933737
135PAK30.10398478
136MET0.09037524
137CDC42BPA0.08642063
138FER0.08418291
139RPS6KA30.07232280
140INSR0.07196213
141RPS6KA10.07048383
142ERBB40.06290712
143PTK2B0.06288893
144MAP2K40.06033402
145SIK30.05969627
146TNK20.05818664
147MTOR0.03277496
148NTRK10.03113688
149MAPK40.02745993
150CDK60.02603010
151MAPK120.02522428
152SRC0.02270452
153ERBB30.02210058
154SIK20.02206014

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004604.08887840
2Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.86351543
3Caffeine metabolism_Homo sapiens_hsa002323.82426581
4Butanoate metabolism_Homo sapiens_hsa006503.70913676
5Complement and coagulation cascades_Homo sapiens_hsa046103.56808962
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.43202414
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.36887015
8Pentose and glucuronate interconversions_Homo sapiens_hsa000403.12295850
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006303.11063736
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.05050806
11Propanoate metabolism_Homo sapiens_hsa006402.96874486
122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.89151396
13Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.62595546
14Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.44242431
15Pyruvate metabolism_Homo sapiens_hsa006202.30344615
16Fatty acid degradation_Homo sapiens_hsa000712.16368678
17Tryptophan metabolism_Homo sapiens_hsa003802.15522561
18Collecting duct acid secretion_Homo sapiens_hsa049662.15108228
19* Peroxisome_Homo sapiens_hsa041462.13573909
20Vitamin digestion and absorption_Homo sapiens_hsa049772.10766016
21Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.93026707
22Fatty acid metabolism_Homo sapiens_hsa012121.87917709
23beta-Alanine metabolism_Homo sapiens_hsa004101.86819257
24Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.71357517
25Bile secretion_Homo sapiens_hsa049761.69897470
26Sulfur metabolism_Homo sapiens_hsa009201.68714965
27Glutathione metabolism_Homo sapiens_hsa004801.66640494
28Linoleic acid metabolism_Homo sapiens_hsa005911.62433383
29Carbon metabolism_Homo sapiens_hsa012001.57107800
30Mineral absorption_Homo sapiens_hsa049781.50365041
31Lysine degradation_Homo sapiens_hsa003101.45160576
32Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.37040253
33Arginine biosynthesis_Homo sapiens_hsa002201.31168620
34Other glycan degradation_Homo sapiens_hsa005111.22875835
35Protein digestion and absorption_Homo sapiens_hsa049741.22629340
36Starch and sucrose metabolism_Homo sapiens_hsa005001.21988140
37* Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.20711586
38Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.19237809
39* Arginine and proline metabolism_Homo sapiens_hsa003301.18651420
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.14319273
41PPAR signaling pathway_Homo sapiens_hsa033201.10316537
42Fructose and mannose metabolism_Homo sapiens_hsa000511.08228340
43Biosynthesis of amino acids_Homo sapiens_hsa012301.06574287
44Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.04809457
45Vitamin B6 metabolism_Homo sapiens_hsa007501.04138844
46Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.02050245
47Prion diseases_Homo sapiens_hsa050201.01672531
48Folate biosynthesis_Homo sapiens_hsa007901.00205780
49Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.98971999
50Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.97048005
51Histidine metabolism_Homo sapiens_hsa003400.93884447
52Nitrogen metabolism_Homo sapiens_hsa009100.92965059
53Glycerolipid metabolism_Homo sapiens_hsa005610.92929087
54Selenocompound metabolism_Homo sapiens_hsa004500.92899570
55Staphylococcus aureus infection_Homo sapiens_hsa051500.92885674
56Phenylalanine metabolism_Homo sapiens_hsa003600.84606246
57Primary bile acid biosynthesis_Homo sapiens_hsa001200.83527899
58Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.81287369
59Carbohydrate digestion and absorption_Homo sapiens_hsa049730.76820820
60Maturity onset diabetes of the young_Homo sapiens_hsa049500.68586272
61Glycosaminoglycan degradation_Homo sapiens_hsa005310.67183180
62Lysosome_Homo sapiens_hsa041420.64176402
63Steroid hormone biosynthesis_Homo sapiens_hsa001400.63354427
64Cysteine and methionine metabolism_Homo sapiens_hsa002700.63103551
65Thyroid hormone synthesis_Homo sapiens_hsa049180.60479823
66Renin-angiotensin system_Homo sapiens_hsa046140.59610940
67Fat digestion and absorption_Homo sapiens_hsa049750.58815340
68Nicotine addiction_Homo sapiens_hsa050330.57058298
69Fatty acid elongation_Homo sapiens_hsa000620.56943150
70Gastric acid secretion_Homo sapiens_hsa049710.56540276
71Oxidative phosphorylation_Homo sapiens_hsa001900.55887508
72Pentose phosphate pathway_Homo sapiens_hsa000300.53293287
73Drug metabolism - other enzymes_Homo sapiens_hsa009830.50788829
74One carbon pool by folate_Homo sapiens_hsa006700.50079483
75* Metabolic pathways_Homo sapiens_hsa011000.48975872
76Chemical carcinogenesis_Homo sapiens_hsa052040.47538501
77GABAergic synapse_Homo sapiens_hsa047270.46632113
78Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.42582022
79Synaptic vesicle cycle_Homo sapiens_hsa047210.42498521
80Arachidonic acid metabolism_Homo sapiens_hsa005900.42028066
81Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.41311946
82Retinol metabolism_Homo sapiens_hsa008300.35077045
83Choline metabolism in cancer_Homo sapiens_hsa052310.33489039
84Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.32888012
85Sulfur relay system_Homo sapiens_hsa041220.32666348
86Serotonergic synapse_Homo sapiens_hsa047260.32002418
87Glutamatergic synapse_Homo sapiens_hsa047240.27067164
88Steroid biosynthesis_Homo sapiens_hsa001000.26400371
89Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.25304820
90Glucagon signaling pathway_Homo sapiens_hsa049220.23705597
91Parkinsons disease_Homo sapiens_hsa050120.23264254
92Vibrio cholerae infection_Homo sapiens_hsa051100.21791418
93Fatty acid biosynthesis_Homo sapiens_hsa000610.21646617
94ABC transporters_Homo sapiens_hsa020100.19704031
95Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.17167944
96Cardiac muscle contraction_Homo sapiens_hsa042600.16916994
97Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.16519714
98Pertussis_Homo sapiens_hsa051330.15186570
99Amphetamine addiction_Homo sapiens_hsa050310.14129433
100Tyrosine metabolism_Homo sapiens_hsa003500.14014959
101Cocaine addiction_Homo sapiens_hsa050300.12741318
102Hedgehog signaling pathway_Homo sapiens_hsa043400.12731297
103Sphingolipid metabolism_Homo sapiens_hsa006000.12003793
104Inositol phosphate metabolism_Homo sapiens_hsa005620.11468721
105Galactose metabolism_Homo sapiens_hsa000520.09841534
106Morphine addiction_Homo sapiens_hsa050320.09229982
107Insulin secretion_Homo sapiens_hsa049110.08175990
108Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.07278885
109Circadian entrainment_Homo sapiens_hsa047130.05733244
110AMPK signaling pathway_Homo sapiens_hsa041520.03266935
111Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.02931538
112Longevity regulating pathway - mammal_Homo sapiens_hsa042110.02404225
113Long-term potentiation_Homo sapiens_hsa047200.00933439
114Systemic lupus erythematosus_Homo sapiens_hsa05322-0.0806139
115Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.0676299
116Pancreatic secretion_Homo sapiens_hsa04972-0.0620390
117Aldosterone synthesis and secretion_Homo sapiens_hsa04925-0.0608187
118Circadian rhythm_Homo sapiens_hsa04710-0.0525374
119Taste transduction_Homo sapiens_hsa04742-0.0504041
120Rheumatoid arthritis_Homo sapiens_hsa05323-0.0443323
121alpha-Linolenic acid metabolism_Homo sapiens_hsa00592-0.0365273
122Dopaminergic synapse_Homo sapiens_hsa04728-0.0334240
123Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0209442
124Insulin resistance_Homo sapiens_hsa04931-0.0205050
125Alzheimers disease_Homo sapiens_hsa05010-0.0142898
126Adipocytokine signaling pathway_Homo sapiens_hsa04920-0.0046355
127Type II diabetes mellitus_Homo sapiens_hsa04930-0.0036105

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