DAOA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that may function as an activator of D-amino acid oxidase, which degrades the gliotransmitter D-serine, a potent activator of N-methyl-D-aspartate (NMDA) type glutamate receptors. Studies also suggest that one encoded isoform may play a role in mitochondrial function and dendritic arborization. Polymorphisms in this gene have been implicated in susceptibility to schizophrenia and bipolar affective disorder. Alternatively spliced transcript variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sphingosine metabolic process (GO:0006670)7.30178798
2sphingoid metabolic process (GO:0046519)6.86309160
3diol metabolic process (GO:0034311)6.52668101
4DNA double-strand break processing (GO:0000729)5.15266721
5regulation of meiosis I (GO:0060631)4.72154133
6serotonin receptor signaling pathway (GO:0007210)4.63843920
7DNA methylation involved in gamete generation (GO:0043046)3.85043833
8piRNA metabolic process (GO:0034587)3.84983780
9detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.82060835
10centriole replication (GO:0007099)3.72904465
11L-fucose metabolic process (GO:0042354)3.62027220
12L-fucose catabolic process (GO:0042355)3.62027220
13fucose catabolic process (GO:0019317)3.62027220
14protein K11-linked deubiquitination (GO:0035871)3.59948547
15positive regulation of meiosis (GO:0045836)3.53795139
16neural tube formation (GO:0001841)3.53645305
17tachykinin receptor signaling pathway (GO:0007217)3.50452513
18protein localization to cilium (GO:0061512)3.46088333
19positive regulation of meiotic cell cycle (GO:0051446)3.44839273
20indole-containing compound catabolic process (GO:0042436)3.44096008
21indolalkylamine catabolic process (GO:0046218)3.44096008
22tryptophan catabolic process (GO:0006569)3.44096008
23regulation of glucokinase activity (GO:0033131)3.37492311
24regulation of hexokinase activity (GO:1903299)3.37492311
25sulfate transmembrane transport (GO:1902358)3.33664857
26DNA deamination (GO:0045006)3.25112487
27sulfate transport (GO:0008272)3.24618070
28intraciliary transport (GO:0042073)3.19537673
29protein-chromophore linkage (GO:0018298)3.18773185
30response to pheromone (GO:0019236)3.17606192
31behavioral response to nicotine (GO:0035095)3.16575221
32heme transport (GO:0015886)3.10144683
33indolalkylamine metabolic process (GO:0006586)3.09871165
34lipopolysaccharide biosynthetic process (GO:0009103)3.07539555
35aromatic amino acid family catabolic process (GO:0009074)3.05778950
36mannosylation (GO:0097502)3.03819621
37glyoxylate metabolic process (GO:0046487)3.02904248
38negative regulation of transcription regulatory region DNA binding (GO:2000678)2.98552027
39peptidyl-histidine modification (GO:0018202)2.98068693
40platelet dense granule organization (GO:0060155)2.96680260
41pyrimidine nucleobase catabolic process (GO:0006208)2.95957668
42proline transport (GO:0015824)2.95061972
43protein complex biogenesis (GO:0070271)2.91126550
44detection of light stimulus involved in sensory perception (GO:0050962)2.88857521
45detection of light stimulus involved in visual perception (GO:0050908)2.88857521
46regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.86952145
47regulation of rhodopsin mediated signaling pathway (GO:0022400)2.80163161
48photoreceptor cell maintenance (GO:0045494)2.80008977
49cellular biogenic amine catabolic process (GO:0042402)2.79699494
50amine catabolic process (GO:0009310)2.79699494
51arginine catabolic process (GO:0006527)2.78198667
52mitochondrial respiratory chain complex I assembly (GO:0032981)2.76351760
53NADH dehydrogenase complex assembly (GO:0010257)2.76351760
54mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.76351760
55tryptophan metabolic process (GO:0006568)2.75658634
56dopamine transport (GO:0015872)2.75574557
57nonmotile primary cilium assembly (GO:0035058)2.74706411
58axoneme assembly (GO:0035082)2.74620271
59flavonoid metabolic process (GO:0009812)2.73201527
60regulation of protein glycosylation (GO:0060049)2.71654568
61replication fork processing (GO:0031297)2.71496402
62adenosine metabolic process (GO:0046085)2.71202938
63ubiquinone biosynthetic process (GO:0006744)2.70022356
64iron coordination entity transport (GO:1901678)2.69298964
65cellular ketone body metabolic process (GO:0046950)2.67912967
66protein localization to Golgi apparatus (GO:0034067)2.66172988
67retinal cone cell development (GO:0046549)2.65428849
68positive regulation of mitochondrial fission (GO:0090141)2.65126285
69mitochondrial respiratory chain complex assembly (GO:0033108)2.64000356
70aspartate family amino acid catabolic process (GO:0009068)2.63547233
71negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.62812358
72L-phenylalanine catabolic process (GO:0006559)2.62672260
73erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.62672260
74adaptation of signaling pathway (GO:0023058)2.62067961
75epithelial cilium movement (GO:0003351)2.61136318
76rhodopsin mediated signaling pathway (GO:0016056)2.60900918
77C4-dicarboxylate transport (GO:0015740)2.60528305
78establishment of protein localization to Golgi (GO:0072600)2.60426952
79organic cation transport (GO:0015695)2.59456491
80pseudouridine synthesis (GO:0001522)2.57426722
81sulfation (GO:0051923)2.56718247
82regulation of nuclear cell cycle DNA replication (GO:0033262)2.56089119
83lipopolysaccharide metabolic process (GO:0008653)2.56038699
84xenobiotic catabolic process (GO:0042178)2.55529644
85detection of mechanical stimulus involved in sensory perception (GO:0050974)2.55371249
86thyroid hormone metabolic process (GO:0042403)2.54982025
87anterograde synaptic vesicle transport (GO:0048490)2.54430683
88aldehyde catabolic process (GO:0046185)2.53829521
89aromatic amino acid family metabolic process (GO:0009072)2.52468626
90glycine transport (GO:0015816)2.52202767
91NAD biosynthetic process (GO:0009435)2.50512121
92membrane lipid biosynthetic process (GO:0046467)2.49902696
93auditory receptor cell stereocilium organization (GO:0060088)2.48652797
94sphingolipid biosynthetic process (GO:0030148)2.47739652
95positive regulation of developmental pigmentation (GO:0048087)2.47604861
96glycolipid biosynthetic process (GO:0009247)2.47069018
97centriole assembly (GO:0098534)2.45217060
98negative regulation of DNA-dependent DNA replication (GO:2000104)2.44625373
99mitochondrial DNA replication (GO:0006264)2.44109658
100embryonic epithelial tube formation (GO:0001838)2.43371499

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela4.07653275
2IGF1R_20145208_ChIP-Seq_DFB_Human3.53445311
3GBX2_23144817_ChIP-Seq_PC3_Human3.43748434
4ZFP57_27257070_Chip-Seq_ESCs_Mouse2.85555981
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.74000627
6VDR_22108803_ChIP-Seq_LS180_Human2.57482198
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.51177711
8CTBP2_25329375_ChIP-Seq_LNCAP_Human2.31524783
9* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.29820472
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.25528197
11TAF15_26573619_Chip-Seq_HEK293_Human2.19967549
12* P300_19829295_ChIP-Seq_ESCs_Human2.11063196
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.02948539
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.99439089
15FUS_26573619_Chip-Seq_HEK293_Human1.96024538
16BCAT_22108803_ChIP-Seq_LS180_Human1.86771549
17CTBP1_25329375_ChIP-Seq_LNCAP_Human1.83490622
18CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.83057683
19ER_23166858_ChIP-Seq_MCF-7_Human1.82031546
20SALL1_21062744_ChIP-ChIP_HESCs_Human1.81582450
21PCGF2_27294783_Chip-Seq_ESCs_Mouse1.78650896
22EWS_26573619_Chip-Seq_HEK293_Human1.70390983
23KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.68362862
24* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.67925911
25EZH2_22144423_ChIP-Seq_EOC_Human1.66706008
26* AR_25329375_ChIP-Seq_VCAP_Human1.65253926
27* PIAS1_25552417_ChIP-Seq_VCAP_Human1.61260688
28HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.60624379
29SMAD4_21799915_ChIP-Seq_A2780_Human1.60605269
30PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.58191272
31MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.57571874
32CBP_20019798_ChIP-Seq_JUKART_Human1.55085895
33IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.55085895
34EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.54273588
35GABP_17652178_ChIP-ChIP_JURKAT_Human1.53973400
36* AR_21572438_ChIP-Seq_LNCaP_Human1.52996667
37NANOG_19829295_ChIP-Seq_ESCs_Human1.52107715
38SOX2_19829295_ChIP-Seq_ESCs_Human1.52107715
39EZH2_27294783_Chip-Seq_NPCs_Mouse1.51167234
40SUZ12_27294783_Chip-Seq_NPCs_Mouse1.50927643
41UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.50921137
42TP53_22573176_ChIP-Seq_HFKS_Human1.50667040
43NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.50279141
44* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.47290895
45NFE2_27457419_Chip-Seq_LIVER_Mouse1.46896090
46EST1_17652178_ChIP-ChIP_JURKAT_Human1.44454280
47EGR1_23403033_ChIP-Seq_LIVER_Mouse1.44436514
48TCF4_23295773_ChIP-Seq_U87_Human1.42026982
49STAT3_23295773_ChIP-Seq_U87_Human1.40814385
50SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.39592602
51MYC_18940864_ChIP-ChIP_HL60_Human1.37471693
52ELK1_19687146_ChIP-ChIP_HELA_Human1.35748729
53FOXA1_21572438_ChIP-Seq_LNCaP_Human1.35203191
54CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.33129832
55CRX_20693478_ChIP-Seq_RETINA_Mouse1.32420992
56TCF4_22108803_ChIP-Seq_LS180_Human1.29702353
57* SMAD3_21741376_ChIP-Seq_EPCs_Human1.29092540
58FLI1_21867929_ChIP-Seq_TH2_Mouse1.28166260
59SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27579303
60KLF5_20875108_ChIP-Seq_MESCs_Mouse1.27095913
61FOXA1_25329375_ChIP-Seq_VCAP_Human1.26328273
62FOXA1_27270436_Chip-Seq_PROSTATE_Human1.26328273
63EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.26186317
64PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.24459218
65* SMAD4_21741376_ChIP-Seq_EPCs_Human1.23051795
66TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22835770
67OCT4_21477851_ChIP-Seq_ESCs_Mouse1.22411526
68NCOR_22424771_ChIP-Seq_293T_Human1.21910278
69GATA3_21878914_ChIP-Seq_MCF-7_Human1.19400244
70* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.18469032
71NOTCH1_21737748_ChIP-Seq_TLL_Human1.15295430
72* RUNX2_22187159_ChIP-Seq_PCA_Human1.14646626
73GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.14346531
74MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.14227338
75CDX2_22108803_ChIP-Seq_LS180_Human1.12072514
76VDR_23849224_ChIP-Seq_CD4+_Human1.10187525
77HOXB7_26014856_ChIP-Seq_BT474_Human1.08382218
78SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.07537047
79PRDM14_20953172_ChIP-Seq_ESCs_Human1.07291651
80LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.07089004
81PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.07082575
82TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.06275274
83PCGF2_27294783_Chip-Seq_NPCs_Mouse1.05716543
84REST_21632747_ChIP-Seq_MESCs_Mouse1.03600219
85AR_20517297_ChIP-Seq_VCAP_Human1.02910622
86TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02468396
87POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.02468396
88OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02399082
89TOP2B_26459242_ChIP-Seq_MCF-7_Human1.02130458
90RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01221321
91NANOG_18555785_Chip-Seq_ESCs_Mouse0.96862557
92FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.96682682
93CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.96511946
94EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.96160683
95HTT_18923047_ChIP-ChIP_STHdh_Human0.95965353
96STAT3_18555785_Chip-Seq_ESCs_Mouse0.95772724
97ETV2_25802403_ChIP-Seq_MESCs_Mouse0.95373225
98RNF2_27304074_Chip-Seq_NSC_Mouse0.94856948
99SRF_21415370_ChIP-Seq_HL-1_Mouse0.94839510
100NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.94012320

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis4.87940688
2MP0003136_yellow_coat_color4.36357259
3MP0002138_abnormal_hepatobiliary_system3.50646157
4MP0002653_abnormal_ependyma_morphology3.40306404
5MP0005171_absent_coat_pigmentation3.27963372
6MP0003195_calcinosis2.84801024
7MP0001968_abnormal_touch/_nociception2.83474556
8MP0002736_abnormal_nociception_after2.46597012
9MP0003646_muscle_fatigue2.45764177
10MP0002876_abnormal_thyroid_physiology2.29149633
11MP0001986_abnormal_taste_sensitivity2.27656304
12MP0005084_abnormal_gallbladder_morpholo2.25723675
13MP0005551_abnormal_eye_electrophysiolog2.21242655
14MP0000569_abnormal_digit_pigmentation2.18815939
15MP0008057_abnormal_DNA_replication2.12758343
16MP0001984_abnormal_olfaction2.09600372
17MP0008877_abnormal_DNA_methylation2.03385710
18MP0009697_abnormal_copulation2.02865011
19MP0003252_abnormal_bile_duct1.94627347
20MP0006292_abnormal_olfactory_placode1.90420103
21MP0005365_abnormal_bile_salt1.86284281
22MP0005646_abnormal_pituitary_gland1.84790350
23MP0005085_abnormal_gallbladder_physiolo1.76876133
24MP0000372_irregular_coat_pigmentation1.76069144
25MP0008872_abnormal_physiological_respon1.75526137
26MP0002139_abnormal_hepatobiliary_system1.75417648
27MP0008875_abnormal_xenobiotic_pharmacok1.75143364
28MP0002254_reproductive_system_inflammat1.73251720
29MP0002735_abnormal_chemical_nociception1.68801802
30MP0000427_abnormal_hair_cycle1.64671769
31MP0009046_muscle_twitch1.61389390
32MP0002938_white_spotting1.55357071
33MP0005670_abnormal_white_adipose1.54373911
34MP0002234_abnormal_pharynx_morphology1.50338993
35MP0002928_abnormal_bile_duct1.46456547
36MP0001486_abnormal_startle_reflex1.46148187
37MP0009745_abnormal_behavioral_response1.44515208
38MP0003045_fibrosis1.41745267
39MP0001501_abnormal_sleep_pattern1.40883435
40MP0001764_abnormal_homeostasis1.40636636
41MP0002102_abnormal_ear_morphology1.38362666
42MP0002163_abnormal_gland_morphology1.37040442
43MP0004147_increased_porphyrin_level1.36805216
44MP0002272_abnormal_nervous_system1.34301930
45MP0003787_abnormal_imprinting1.33856539
46MP0005253_abnormal_eye_physiology1.32557891
47MP0005410_abnormal_fertilization1.31886483
48MP0006035_abnormal_mitochondrial_morpho1.26273748
49MP0005174_abnormal_tail_pigmentation1.25613328
50MP0003718_maternal_effect1.24976621
51MP0001970_abnormal_pain_threshold1.24672551
52MP0002733_abnormal_thermal_nociception1.21102883
53MP0004215_abnormal_myocardial_fiber1.20354102
54MP0002572_abnormal_emotion/affect_behav1.18894983
55MP0006276_abnormal_autonomic_nervous1.18631737
56MP0004142_abnormal_muscle_tone1.13366767
57MP0005360_urolithiasis1.11939661
58MP0005645_abnormal_hypothalamus_physiol1.11918332
59MP0003806_abnormal_nucleotide_metabolis1.09802838
60MP0005075_abnormal_melanosome_morpholog1.09013869
61MP0005167_abnormal_blood-brain_barrier1.08956996
62MP0006036_abnormal_mitochondrial_physio1.08446755
63MP0003890_abnormal_embryonic-extraembry1.03583581
64MP0006072_abnormal_retinal_apoptosis1.00924319
65MP0003635_abnormal_synaptic_transmissio0.98961379
66MP0005379_endocrine/exocrine_gland_phen0.97804568
67MP0004043_abnormal_pH_regulation0.97115025
68MP0001905_abnormal_dopamine_level0.94089821
69MP0000631_abnormal_neuroendocrine_gland0.92462664
70MP0003183_abnormal_peptide_metabolism0.91246896
71MP0005395_other_phenotype0.90639097
72MP0003880_abnormal_central_pattern0.88287813
73MP0002168_other_aberrant_phenotype0.86375533
74MP0002064_seizures0.84680502
75MP0002734_abnormal_mechanical_nocicepti0.83632564
76MP0002132_abnormal_respiratory_system0.83507855
77MP0003137_abnormal_impulse_conducting0.83105050
78MP0003186_abnormal_redox_activity0.81582898
79MP0006054_spinal_hemorrhage0.81501541
80MP0000230_abnormal_systemic_arterial0.80142361
81MP0002229_neurodegeneration0.80047563
82MP0002067_abnormal_sensory_capabilities0.76378200
83MP0004270_analgesia0.75665089
84MP0005332_abnormal_amino_acid0.75465213
85MP0010386_abnormal_urinary_bladder0.74951144
86MP0005266_abnormal_metabolism0.74491770
87MP0001324_abnormal_eye_pigmentation0.73186840
88MP0008789_abnormal_olfactory_epithelium0.69034584
89MP0010329_abnormal_lipoprotein_level0.68669548
90MP0002063_abnormal_learning/memory/cond0.66627764
91MP0000778_abnormal_nervous_system0.66582349
92MP0002160_abnormal_reproductive_system0.66424358
93MP0002095_abnormal_skin_pigmentation0.66280630
94MP0000015_abnormal_ear_pigmentation0.65985558
95MP0003698_abnormal_male_reproductive0.65069172
96MP0001929_abnormal_gametogenesis0.64866458
97MP0005195_abnormal_posterior_eye0.64658131
98MP0003567_abnormal_fetal_cardiomyocyte0.64464886
99MP0000749_muscle_degeneration0.64091117
100MP0002557_abnormal_social/conspecific_i0.62879643

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.84739645
2Focal motor seizures (HP:0011153)4.40781654
3Abnormality of macular pigmentation (HP:0008002)3.74591450
4Amelogenesis imperfecta (HP:0000705)3.60028799
5Pancreatic fibrosis (HP:0100732)3.55535685
6Abnormality of midbrain morphology (HP:0002418)3.49011466
7Molar tooth sign on MRI (HP:0002419)3.49011466
8Nephronophthisis (HP:0000090)3.37817591
9Progressive inability to walk (HP:0002505)3.19787299
10Abnormality of the renal cortex (HP:0011035)3.18292840
11True hermaphroditism (HP:0010459)3.12967508
12Type II lissencephaly (HP:0007260)3.06226378
13Hyperventilation (HP:0002883)3.05599397
14Abnormality of the renal medulla (HP:0100957)3.05019496
15Stomach cancer (HP:0012126)3.00559715
16Pendular nystagmus (HP:0012043)2.93879659
173-Methylglutaconic aciduria (HP:0003535)2.92611796
18Abnormal drinking behavior (HP:0030082)2.92605371
19Polydipsia (HP:0001959)2.92605371
20Tubular atrophy (HP:0000092)2.92123982
21Type 2 muscle fiber atrophy (HP:0003554)2.69917120
22Cystic liver disease (HP:0006706)2.68555446
23Congenital stationary night blindness (HP:0007642)2.67500167
24Absent speech (HP:0001344)2.66112375
25Abnormal biliary tract physiology (HP:0012439)2.58704394
26Bile duct proliferation (HP:0001408)2.58704394
27Colon cancer (HP:0003003)2.57475874
28Parakeratosis (HP:0001036)2.46854346
29Cerebellar dysplasia (HP:0007033)2.39529701
30Abnormality of the labia minora (HP:0012880)2.39232631
31Abolished electroretinogram (ERG) (HP:0000550)2.37489261
32Aplasia/Hypoplasia of the uvula (HP:0010293)2.36124227
33Inability to walk (HP:0002540)2.34402861
34Attenuation of retinal blood vessels (HP:0007843)2.33048896
35Decreased circulating renin level (HP:0003351)2.29188217
36Dialeptic seizures (HP:0011146)2.28397719
37Hyperglycinuria (HP:0003108)2.27778703
38Chronic hepatic failure (HP:0100626)2.24750624
39Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.23601328
40Medial flaring of the eyebrow (HP:0010747)2.20589024
41Muscle fiber atrophy (HP:0100295)2.14699039
42Erythroderma (HP:0001019)2.13698089
43Acute encephalopathy (HP:0006846)2.11377733
44Focal seizures (HP:0007359)2.10698252
45Mesangial abnormality (HP:0001966)2.09762221
46Congenital sensorineural hearing impairment (HP:0008527)2.07547231
47Keratoconus (HP:0000563)2.05831981
48Increased corneal curvature (HP:0100692)2.05831981
49Polyuria (HP:0000103)2.05149685
50Increased CSF lactate (HP:0002490)2.04623835
51Albinism (HP:0001022)2.01249469
52Neonatal respiratory distress (HP:0002643)2.01038525
53Hemiparesis (HP:0001269)1.99958814
54Acute necrotizing encephalopathy (HP:0006965)1.99886447
55Lissencephaly (HP:0001339)1.97956021
56Gait imbalance (HP:0002141)1.97213827
57Decreased central vision (HP:0007663)1.96954104
58Progressive macrocephaly (HP:0004481)1.93475162
59Limb dystonia (HP:0002451)1.93430194
60Type I transferrin isoform profile (HP:0003642)1.92759200
61Aplasia/Hypoplasia of the tongue (HP:0010295)1.92282280
62Nephrogenic diabetes insipidus (HP:0009806)1.91691235
63Congenital hepatic fibrosis (HP:0002612)1.90695609
64Thyroiditis (HP:0100646)1.90632885
65Ectopic kidney (HP:0000086)1.90517430
66Ketoacidosis (HP:0001993)1.89955747
67Panhypogammaglobulinemia (HP:0003139)1.89370025
68Decreased electroretinogram (ERG) amplitude (HP:0000654)1.89030431
69Mitochondrial inheritance (HP:0001427)1.88831566
70Central scotoma (HP:0000603)1.88068790
71Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.86950796
72Abnormal protein N-linked glycosylation (HP:0012347)1.86950796
73Abnormal protein glycosylation (HP:0012346)1.86950796
74Abnormal glycosylation (HP:0012345)1.86950796
75Small hand (HP:0200055)1.86625287
76Sensory axonal neuropathy (HP:0003390)1.84547675
77Abnormality of serine family amino acid metabolism (HP:0010894)1.83111963
78Abnormality of glycine metabolism (HP:0010895)1.83111963
79Congenital primary aphakia (HP:0007707)1.82172989
80Severe visual impairment (HP:0001141)1.79245622
81Aplasia/Hypoplasia involving the musculature (HP:0001460)1.78816740
82Potter facies (HP:0002009)1.78051735
83Facial shape deformation (HP:0011334)1.78051735
84Aplasia/Hypoplasia of the tibia (HP:0005772)1.77133372
85Furrowed tongue (HP:0000221)1.76217711
86Renal cortical cysts (HP:0000803)1.74377894
87Large for gestational age (HP:0001520)1.73143219
88Retinitis pigmentosa (HP:0000510)1.72177666
89Abnormal mitochondria in muscle tissue (HP:0008316)1.71590132
90Abnormality of the fovea (HP:0000493)1.71333416
91Aplasia/Hypoplasia of the spleen (HP:0010451)1.71205025
92Abnormality of B cell number (HP:0010975)1.71077080
93Abnormality of dental color (HP:0011073)1.69368556
94Carpal bone hypoplasia (HP:0001498)1.68293235
95Difficulty walking (HP:0002355)1.68175656
96Drooling (HP:0002307)1.68040798
97Generalized myoclonic seizures (HP:0002123)1.68023672
98Abnormal urine output (HP:0012590)1.67995391
99Abnormality of aromatic amino acid family metabolism (HP:0004338)1.66853535
100Ulnar claw (HP:0001178)1.65809138

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.73186629
2LATS14.37410504
3STK38L4.09317829
4INSRR3.61716550
5BMPR1B3.09218998
6ZAK2.78739869
7PINK12.73979617
8PRKD32.48664965
9MUSK2.31056932
10NUAK12.07117264
11TNIK1.79882227
12MAPK131.78926250
13WNK31.78406018
14ACVR1B1.72395930
15TRIM281.66147858
16ADRBK21.64760793
17EPHA41.62876021
18MAPKAPK31.57086859
19ERBB31.52073124
20CASK1.38726138
21STK31.35503323
22TAOK31.33745288
23STK391.33399845
24PLK21.33363429
25PIK3CG1.30287523
26MARK11.28577723
27NLK1.25946532
28OXSR11.25922214
29TXK1.25697583
30MAP4K21.21852274
31GRK11.20514893
32BCKDK1.16763783
33EIF2AK31.14021362
34TEC1.08275514
35PLK41.08167450
36DYRK21.07116059
37WNK41.02646558
38CSNK1A1L1.00852364
39STK380.99587211
40SRPK10.96885906
41EIF2AK10.95264941
42PRKCE0.90033191
43DAPK20.88867640
44FER0.88007536
45PAK30.86612161
46NME10.83822580
47MAP3K120.82277322
48NTRK30.82071482
49GRK70.82003398
50LATS20.79188744
51ADRBK10.78710626
52TLK10.76277423
53PRKG20.74380081
54PRKCG0.74137145
55PTK2B0.73786506
56MAP3K40.66626481
57CSNK1G20.66604722
58CSNK1G30.65069305
59MAP2K60.64720067
60VRK10.63854284
61PHKG10.63461062
62PHKG20.63461062
63TNK20.62157124
64MAPKAPK50.60121065
65TGFBR10.59209383
66RPS6KA40.56568580
67DAPK10.55814182
68MST40.55160866
69PLK30.50459048
70CSNK1G10.50308796
71CAMK2A0.49593698
72GRK50.49267555
73MAP2K20.45980926
74CSNK1D0.45199410
75DYRK30.42590112
76NTRK20.41214330
77PRKACA0.40583314
78BCR0.40179010
79ITK0.39805014
80CCNB10.39239055
81CSNK1A10.38353656
82EPHA30.37875449
83TIE10.37682954
84ABL10.35907563
85PRKAA20.35822633
86CAMK10.35277598
87ATR0.34494202
88CHEK20.33555177
89PRKCQ0.32779098
90ATM0.32743994
91IKBKB0.31875241
92PRKCZ0.31391520
93MINK10.31114944
94PRKCA0.29796789
95PLK10.29502832
96CAMK2D0.28979320
97EIF2AK20.27639230
98MKNK10.26732036
99RPS6KA50.26374758
100PKN10.25822172

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047442.89808529
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.81048696
3Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.80339869
4Butanoate metabolism_Homo sapiens_hsa006502.62762519
5Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.43810507
6Protein export_Homo sapiens_hsa030602.16421199
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.09355234
8Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.05350824
9Homologous recombination_Homo sapiens_hsa034401.97378794
10Sphingolipid metabolism_Homo sapiens_hsa006001.96995535
11Nicotine addiction_Homo sapiens_hsa050331.89183060
12Propanoate metabolism_Homo sapiens_hsa006401.87293095
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.84500381
14Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.80600662
15Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.79135868
16Linoleic acid metabolism_Homo sapiens_hsa005911.78997970
17Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.78252963
18Oxidative phosphorylation_Homo sapiens_hsa001901.74530254
19Maturity onset diabetes of the young_Homo sapiens_hsa049501.72076018
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.69605284
21Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.69192770
22Selenocompound metabolism_Homo sapiens_hsa004501.63632474
23Tryptophan metabolism_Homo sapiens_hsa003801.53235331
24Fanconi anemia pathway_Homo sapiens_hsa034601.53066173
25Non-homologous end-joining_Homo sapiens_hsa034501.49864389
26Peroxisome_Homo sapiens_hsa041461.44839306
27One carbon pool by folate_Homo sapiens_hsa006701.44663393
28Ether lipid metabolism_Homo sapiens_hsa005651.44319805
29Steroid hormone biosynthesis_Homo sapiens_hsa001401.40209265
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.39673467
31Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.37335773
32Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.36330158
33Parkinsons disease_Homo sapiens_hsa050121.35839596
34Olfactory transduction_Homo sapiens_hsa047401.33972952
35RNA polymerase_Homo sapiens_hsa030201.28020306
36Morphine addiction_Homo sapiens_hsa050321.24614678
37Basal transcription factors_Homo sapiens_hsa030221.15528935
38Chemical carcinogenesis_Homo sapiens_hsa052041.14397895
39Taste transduction_Homo sapiens_hsa047421.12822246
40Serotonergic synapse_Homo sapiens_hsa047261.11456997
41Steroid biosynthesis_Homo sapiens_hsa001001.08720054
42GABAergic synapse_Homo sapiens_hsa047271.07614454
43Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.07192393
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.06211514
45Nitrogen metabolism_Homo sapiens_hsa009101.03093928
46Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.01707492
47Glycerolipid metabolism_Homo sapiens_hsa005611.01213028
48Collecting duct acid secretion_Homo sapiens_hsa049661.00714539
49Dorso-ventral axis formation_Homo sapiens_hsa043200.98683612
50Retinol metabolism_Homo sapiens_hsa008300.98647051
51Fatty acid elongation_Homo sapiens_hsa000620.97819937
52Arachidonic acid metabolism_Homo sapiens_hsa005900.97714778
53Primary bile acid biosynthesis_Homo sapiens_hsa001200.96205880
54Proteasome_Homo sapiens_hsa030500.94312983
55Glutathione metabolism_Homo sapiens_hsa004800.91956256
56Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.85636839
57Metabolic pathways_Homo sapiens_hsa011000.85151984
58Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.83068305
59Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.82794182
60Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.82365289
61Pyruvate metabolism_Homo sapiens_hsa006200.81078758
62Primary immunodeficiency_Homo sapiens_hsa053400.79778979
63Huntingtons disease_Homo sapiens_hsa050160.78672664
64RNA degradation_Homo sapiens_hsa030180.76632813
65Ovarian steroidogenesis_Homo sapiens_hsa049130.75596684
66Fatty acid metabolism_Homo sapiens_hsa012120.75308917
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.74919864
68Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.73410988
69SNARE interactions in vesicular transport_Homo sapiens_hsa041300.72757603
70Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.71849575
71Base excision repair_Homo sapiens_hsa034100.71526408
72Caffeine metabolism_Homo sapiens_hsa002320.71481732
73Circadian entrainment_Homo sapiens_hsa047130.71149058
74beta-Alanine metabolism_Homo sapiens_hsa004100.71117789
75Fatty acid degradation_Homo sapiens_hsa000710.68205008
76ABC transporters_Homo sapiens_hsa020100.67986385
77Mismatch repair_Homo sapiens_hsa034300.67965407
78Alzheimers disease_Homo sapiens_hsa050100.67289768
79Glycerophospholipid metabolism_Homo sapiens_hsa005640.66572986
80Pyrimidine metabolism_Homo sapiens_hsa002400.65041012
81Pentose and glucuronate interconversions_Homo sapiens_hsa000400.63520546
82Arginine and proline metabolism_Homo sapiens_hsa003300.62879286
83Purine metabolism_Homo sapiens_hsa002300.61870312
84Salivary secretion_Homo sapiens_hsa049700.59304049
85Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.58839214
86Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.57224885
87Histidine metabolism_Homo sapiens_hsa003400.56943578
88Calcium signaling pathway_Homo sapiens_hsa040200.56124095
89Sulfur metabolism_Homo sapiens_hsa009200.53015584
90DNA replication_Homo sapiens_hsa030300.51616314
91Glutamatergic synapse_Homo sapiens_hsa047240.50953944
92N-Glycan biosynthesis_Homo sapiens_hsa005100.48817760
93Drug metabolism - other enzymes_Homo sapiens_hsa009830.47843906
94Folate biosynthesis_Homo sapiens_hsa007900.47023240
95Intestinal immune network for IgA production_Homo sapiens_hsa046720.44488255
96Phenylalanine metabolism_Homo sapiens_hsa003600.43590570
97Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.42929993
98Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.41154636
99Fat digestion and absorption_Homo sapiens_hsa049750.40618132
100Regulation of autophagy_Homo sapiens_hsa041400.40246084

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