DAP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a basic, proline-rich, 15-kD protein. The protein acts as a positive mediator of programmed cell death that is induced by interferon-gamma. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)5.44465157
2COPI coating of Golgi vesicle (GO:0048205)5.44465157
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)5.02293768
4protein maturation by protein folding (GO:0022417)4.93591571
5skin morphogenesis (GO:0043589)4.88178795
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.85879829
7L-phenylalanine catabolic process (GO:0006559)4.85879829
8protein retention in ER lumen (GO:0006621)4.83972502
9erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.73165342
10L-phenylalanine metabolic process (GO:0006558)4.73165342
11aromatic amino acid family catabolic process (GO:0009074)4.18798965
12intestinal cholesterol absorption (GO:0030299)4.18432883
13protein carboxylation (GO:0018214)4.10626920
14peptidyl-glutamic acid carboxylation (GO:0017187)4.10626920
15COPII vesicle coating (GO:0048208)4.02270949
16signal peptide processing (GO:0006465)4.01355642
17barbed-end actin filament capping (GO:0051016)3.87362421
18regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.79983991
19triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.74853211
20regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.70831674
21protein localization to endosome (GO:0036010)3.69923418
22sulfur amino acid catabolic process (GO:0000098)3.69586972
23pinocytosis (GO:0006907)3.65876112
24extracellular fibril organization (GO:0043206)3.65849838
25negative regulation of fibrinolysis (GO:0051918)3.62802254
26basement membrane organization (GO:0071711)3.62490036
27cell adhesion mediated by integrin (GO:0033627)3.60066366
28tryptophan catabolic process (GO:0006569)3.59452895
29indole-containing compound catabolic process (GO:0042436)3.59452895
30indolalkylamine catabolic process (GO:0046218)3.59452895
31cysteine metabolic process (GO:0006534)3.59417482
32alpha-linolenic acid metabolic process (GO:0036109)3.57926254
33tryptophan metabolic process (GO:0006568)3.51242660
34valine metabolic process (GO:0006573)3.44980443
35type B pancreatic cell proliferation (GO:0044342)3.44478641
36fibril organization (GO:0097435)3.41467083
37exocrine pancreas development (GO:0031017)3.41053589
38kynurenine metabolic process (GO:0070189)3.39938750
39glyoxylate metabolic process (GO:0046487)3.39696344
40regulation of extracellular matrix disassembly (GO:0010715)3.39490654
41regulation of fibrinolysis (GO:0051917)3.38080031
42negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.37823207
43high-density lipoprotein particle remodeling (GO:0034375)3.36470766
44complement activation, alternative pathway (GO:0006957)3.34794027
45pentose-phosphate shunt (GO:0006098)3.30818412
46bile acid biosynthetic process (GO:0006699)3.27712027
47regulation of protein activation cascade (GO:2000257)3.26280750
48fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.23986947
49vesicle coating (GO:0006901)3.18435773
504-hydroxyproline metabolic process (GO:0019471)3.18069229
51urea metabolic process (GO:0019627)3.16802934
52urea cycle (GO:0000050)3.16802934
53hyaluronan catabolic process (GO:0030214)3.16761672
54homocysteine metabolic process (GO:0050667)3.16137581
55glucose catabolic process (GO:0006007)3.11105421
56actin filament depolymerization (GO:0030042)3.10620816
57regulation of early endosome to late endosome transport (GO:2000641)3.10484090
58regulation of complement activation (GO:0030449)3.08530559
59activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.06981830
60regulation of triglyceride catabolic process (GO:0010896)3.06634265
61stress fiber assembly (GO:0043149)3.06099976
62aromatic amino acid family metabolic process (GO:0009072)3.05696968
63regulation of metalloenzyme activity (GO:0048552)3.04296219
64adhesion of symbiont to host (GO:0044406)3.01408010
65regulation of plasminogen activation (GO:0010755)3.00978311
66plasma lipoprotein particle clearance (GO:0034381)3.00747152
67retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.00259976
68peptidyl-proline hydroxylation (GO:0019511)2.97399563
69positive regulation of extracellular matrix organization (GO:1903055)2.97298982
70regulation of cholesterol esterification (GO:0010872)2.97138167
71acylglycerol homeostasis (GO:0055090)2.96994969
72triglyceride homeostasis (GO:0070328)2.96994969
73positive regulation of nuclease activity (GO:0032075)2.96468956
74protein-lipid complex remodeling (GO:0034368)2.95523397
75macromolecular complex remodeling (GO:0034367)2.95523397
76plasma lipoprotein particle remodeling (GO:0034369)2.95523397
77reverse cholesterol transport (GO:0043691)2.94107210
78UDP-N-acetylglucosamine metabolic process (GO:0006047)2.93291124
79GDP-mannose metabolic process (GO:0019673)2.92510696
80nitrogen cycle metabolic process (GO:0071941)2.92411848
81aldehyde catabolic process (GO:0046185)2.89651333
82mesodermal cell differentiation (GO:0048333)2.89633242
83phospholipid efflux (GO:0033700)2.89265760
84fibrinolysis (GO:0042730)2.86739548
85endoplasmic reticulum unfolded protein response (GO:0030968)2.86476140
86cellular glucuronidation (GO:0052695)2.85455673
87protein hydroxylation (GO:0018126)2.84768482
88virion attachment to host cell (GO:0019062)2.84276693
89adhesion of symbiont to host cell (GO:0044650)2.84276693
90tyrosine metabolic process (GO:0006570)2.84225517
91acute-phase response (GO:0006953)2.83659026
92hypotonic response (GO:0006971)2.83502303
93cellular modified amino acid catabolic process (GO:0042219)2.83327565
94NADPH regeneration (GO:0006740)2.82949979
95bile acid metabolic process (GO:0008206)2.79632791
96endodermal cell differentiation (GO:0035987)2.79469396
97cellular response to unfolded protein (GO:0034620)2.78718403
98epithelial cell-cell adhesion (GO:0090136)2.77732901
99positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.77196074
100antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.76517235
101antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.76517235
102positive regulation of fatty acid biosynthetic process (GO:0045723)2.76086656
103coenzyme catabolic process (GO:0009109)2.74973923
104lysine catabolic process (GO:0006554)2.74407746
105lysine metabolic process (GO:0006553)2.74407746
106cofactor catabolic process (GO:0051187)2.74123440
107regulation of cholesterol homeostasis (GO:2000188)2.73168133
108positive regulation of triglyceride lipase activity (GO:0061365)2.72331462
109positive regulation of lipoprotein lipase activity (GO:0051006)2.72331462
110regulation of nuclease activity (GO:0032069)2.72042943
111proline biosynthetic process (GO:0006561)2.71734035
112positive regulation of osteoblast proliferation (GO:0033690)2.71364036
113amino-acid betaine metabolic process (GO:0006577)2.71266177
114regulation of apoptotic process involved in morphogenesis (GO:1902337)2.68705965
115muscle cell migration (GO:0014812)2.68131150
116glucuronate metabolic process (GO:0019585)2.67853785
117uronic acid metabolic process (GO:0006063)2.67853785
118platelet degranulation (GO:0002576)2.67209461
119cellular response to topologically incorrect protein (GO:0035967)2.66919007
120positive regulation of blood vessel endothelial cell migration (GO:0043536)2.66911056
121intestinal absorption (GO:0050892)2.66381841
122negative regulation of cholesterol transport (GO:0032375)2.66002636
123negative regulation of sterol transport (GO:0032372)2.66002636
124negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.65340673
125serine family amino acid biosynthetic process (GO:0009070)2.65175950
126membrane raft organization (GO:0031579)2.65168673
127ER-nucleus signaling pathway (GO:0006984)2.65060031
128lipoprotein metabolic process (GO:0042157)2.64239383
129indolalkylamine metabolic process (GO:0006586)2.63605087
130opsonization (GO:0008228)2.62058044
131xenobiotic catabolic process (GO:0042178)2.61685991
132positive regulation of endothelial cell apoptotic process (GO:2000353)2.61606333
133positive regulation of receptor recycling (GO:0001921)2.61444643
134benzene-containing compound metabolic process (GO:0042537)2.61428911
135positive regulation of Cdc42 GTPase activity (GO:0043089)2.59670063
136UV protection (GO:0009650)2.58648540
137alpha-amino acid catabolic process (GO:1901606)2.58616152
138endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.58560072
139membrane protein ectodomain proteolysis (GO:0006509)2.57699404
140serine family amino acid catabolic process (GO:0009071)2.57647017
141bile acid and bile salt transport (GO:0015721)2.57338165
142glycine metabolic process (GO:0006544)2.56620592
143disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.55644175
144killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.55644175
145protein heterotrimerization (GO:0070208)2.54817020
146endocrine pancreas development (GO:0031018)2.53300604
147positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.52380583
148ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.50173410
149cell-substrate junction assembly (GO:0007044)2.49946577
150positive regulation of triglyceride metabolic process (GO:0090208)2.48969865
151negative regulation of protein localization to plasma membrane (GO:1903077)2.47875167
152collagen fibril organization (GO:0030199)2.47617681
153nucleotide-sugar biosynthetic process (GO:0009226)2.47035500
154apoptotic cell clearance (GO:0043277)2.46233301
155mitotic nuclear envelope reassembly (GO:0007084)2.44913397
156nuclear envelope reassembly (GO:0031468)2.44913397
157maintenance of protein localization in organelle (GO:0072595)2.44776712
158regulation of collagen metabolic process (GO:0010712)2.44459888
159platelet aggregation (GO:0070527)2.43363744
160positive regulation of pseudopodium assembly (GO:0031274)2.42064489
161regulation of extracellular matrix organization (GO:1903053)2.41886810
162negative regulation of cell size (GO:0045792)2.40943232
163glucose 6-phosphate metabolic process (GO:0051156)2.39634310
164endocardial cushion development (GO:0003197)2.38176931
165desmosome organization (GO:0002934)2.36968146
166focal adhesion assembly (GO:0048041)2.36587676
167cell-substrate adherens junction assembly (GO:0007045)2.36587676
168positive regulation of substrate adhesion-dependent cell spreading (GO:1900026)2.36548103
169embryo implantation (GO:0007566)2.35589889
170substrate-dependent cell migration (GO:0006929)2.35086876
171adherens junction assembly (GO:0034333)2.34567401
172regulation of integrin-mediated signaling pathway (GO:2001044)2.32949661
173proline metabolic process (GO:0006560)2.30565645
174deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.28482039
175glycosphingolipid catabolic process (GO:0046479)2.28069224
176positive regulation of collagen biosynthetic process (GO:0032967)2.28047127
177collagen metabolic process (GO:0032963)2.27924248
178glycolipid catabolic process (GO:0019377)2.25649260
179positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.25462879
180branching involved in mammary gland duct morphogenesis (GO:0060444)2.24159819
181cellular copper ion homeostasis (GO:0006878)2.23675463
182vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.22775660

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.53881902
2* RXR_22158963_ChIP-Seq_LIVER_Mouse4.80241545
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.34014884
4EGR1_23403033_ChIP-Seq_LIVER_Mouse3.62698122
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.58011792
6* LXR_22158963_ChIP-Seq_LIVER_Mouse3.57551243
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.52861692
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.50218512
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.68914956
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.67025084
11ZNF263_19887448_ChIP-Seq_K562_Human2.43054964
12RARG_19884340_ChIP-ChIP_MEFs_Mouse2.35102617
13* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.24619380
14RACK7_27058665_Chip-Seq_MCF-7_Human2.12582268
15GATA1_22025678_ChIP-Seq_K562_Human2.12245835
16TP63_17297297_ChIP-ChIP_HaCaT_Human2.11108624
17STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.01970269
18HIF1A_21447827_ChIP-Seq_MCF-7_Human1.94094346
19KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.91764146
20CLOCK_20551151_ChIP-Seq_293T_Human1.91434602
21NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.88298164
22TRIM28_21343339_ChIP-Seq_HEK293_Human1.86909860
23IRF8_21731497_ChIP-ChIP_J774_Mouse1.82163477
24ELF1_17652178_ChIP-ChIP_JURKAT_Human1.80590299
25NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.78896439
26HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.78481919
27IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.76128354
28RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.73910231
29DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.73415174
30EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.69783321
31ESR2_21235772_ChIP-Seq_MCF-7_Human1.67210669
32MYB_21317192_ChIP-Seq_ERMYB_Mouse1.67036272
33EGR1_19374776_ChIP-ChIP_THP-1_Human1.65790328
34STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.64167054
35NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.63550287
36KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.58176522
37MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.56977601
38* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.52600344
39CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.52391647
40MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.51762963
41KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.49897069
42TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.46093858
43P300_27058665_Chip-Seq_ZR-75-30cells_Human1.44420011
44* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.42687279
45BRD4_27068464_Chip-Seq_AML-cells_Mouse1.41619032
46TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.41523167
47SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.41425634
48KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.40725761
49SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.39732502
50UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.38538662
51KDM2B_26808549_Chip-Seq_SUP-B15_Human1.37994185
52IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.36629650
53FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.35543788
54TET1_21451524_ChIP-Seq_MESCs_Mouse1.34763447
55IRF8_27001747_Chip-Seq_BMDM_Mouse1.34237168
56TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.31985966
57ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.31610562
58SRY_22984422_ChIP-ChIP_TESTIS_Rat1.29141327
59NCOR1_26117541_ChIP-Seq_K562_Human1.28199905
60FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.27854204
61TP53_22127205_ChIP-Seq_IMR90_Human1.27437058
62CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.26855596
63SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.23751279
64SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.23320771
65SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.23320771
66TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23067062
67ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.22185133
68GATA2_21666600_ChIP-Seq_HMVEC_Human1.21773755
69POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.21105491
70* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.21064093
71TCF7_22412390_ChIP-Seq_EML_Mouse1.20260270
72CTCF_27219007_Chip-Seq_ERYTHROID_Human1.19473573
73NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.18817132
74SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.18702635
75PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.18054952
76ZFX_18555785_ChIP-Seq_MESCs_Mouse1.17105893
77PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.16570730
78SOX2_27498859_Chip-Seq_STOMACH_Mouse1.16150055
79TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.15694655
80TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.15289023
81ESR1_21235772_ChIP-Seq_MCF-7_Human1.14862227
82GATA4_25053715_ChIP-Seq_YYC3_Human1.13981871
83* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.13398792
84UBF1/2_26484160_Chip-Seq_HMECs_Human1.13213962
85GABP_17652178_ChIP-ChIP_JURKAT_Human1.13184186
86WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.12360739
87NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.10873174
88SPI1_23547873_ChIP-Seq_NB4_Human1.10245074
89TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.09510187
90ERG_20887958_ChIP-Seq_HPC-7_Mouse1.08798480
91HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.06728560
92PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.06533213
93KDM2B_26808549_Chip-Seq_DND41_Human1.06496784
94HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.06252886
95TFEB_21752829_ChIP-Seq_HELA_Human1.03794090
96CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.03709422
97* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.03334764
98* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.03021086
99GATA1_22383799_ChIP-Seq_G1ME_Mouse1.02807419
100SMC1_22415368_ChIP-Seq_MEFs_Mouse1.01945998
101CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01652461
102* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.01379948
103ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.00678778
104* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.00174091
105NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.99617829
106MYB_26560356_Chip-Seq_TH2_Human0.99558167
107SA1_27219007_Chip-Seq_ERYTHROID_Human0.99454795
108JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99268939
109GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.99261157
110* STAT4_19710469_ChIP-ChIP_TH1__Mouse0.98571859
111ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.98408957
112CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98384708
113SOX2_20726797_ChIP-Seq_SW620_Human0.98160888
114ELK3_25401928_ChIP-Seq_HUVEC_Human0.97481116
115PPAR_26484153_Chip-Seq_NCI-H1993_Human0.96144313
116CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96092294
117TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.95970989
118ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.95941223
119P68_20966046_ChIP-Seq_HELA_Human0.95801800
120VDR_24763502_ChIP-Seq_THP-1_Human0.95717211
121* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.95272922
122NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.95245844
123MYC_22102868_ChIP-Seq_BL_Human0.95221993
124MYC_18358816_ChIP-ChIP_MESCs_Mouse0.94938673
125SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.93923091
126* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.93462693
127SCL_19346495_ChIP-Seq_HPC-7_Human0.93089969
128* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.92993744
129KDM2B_26808549_Chip-Seq_K562_Human0.92811540
130SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.92778869
131ATF3_27146783_Chip-Seq_COLON_Human0.92404078
132MAF_26560356_Chip-Seq_TH1_Human0.92264442
133ELF1_20517297_ChIP-Seq_JURKAT_Human0.91546515
134MYB_26560356_Chip-Seq_TH1_Human0.91169273
135* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.91042480
136STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.90999350
137RUNX1_22412390_ChIP-Seq_EML_Mouse0.90794818
138KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.90719902
139AR_21909140_ChIP-Seq_LNCAP_Human0.90526413
140* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.90484438
141* LXR_22292898_ChIP-Seq_THP-1_Human0.89686970
142VDR_21846776_ChIP-Seq_THP-1_Human0.89533195
143ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.88269482
144THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.87939674
145FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.85609678
146FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.85507499
147JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.85040637
148* LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.84835265
149PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.83823666
150STAT3_1855785_ChIP-Seq_MESCs_Mouse0.83166976
151P63_26484246_Chip-Seq_KERATINOCYTES_Human0.83032965
152DCP1A_22483619_ChIP-Seq_HELA_Human0.82459337
153PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.81729235

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.82417759
2MP0005365_abnormal_bile_salt4.13625866
3MP0005360_urolithiasis3.79886058
4MP0005085_abnormal_gallbladder_physiolo3.48427896
5MP0005083_abnormal_biliary_tract2.90137585
6MP0004272_abnormal_basement_membrane2.82602792
7MP0003806_abnormal_nucleotide_metabolis2.69396331
8MP0003195_calcinosis2.68205831
9MP0008438_abnormal_cutaneous_collagen2.65635654
10MP0001666_abnormal_nutrient_absorption2.59699661
11MP0003252_abnormal_bile_duct2.49509873
12MP0009840_abnormal_foam_cell2.47594158
13MP0008875_abnormal_xenobiotic_pharmacok2.44980310
14MP0005220_abnormal_exocrine_pancreas2.24790770
15MP0003705_abnormal_hypodermis_morpholog2.10172752
16MP0010329_abnormal_lipoprotein_level2.04828512
17MP0002877_abnormal_melanocyte_morpholog2.03207290
18MP0003436_decreased_susceptibility_to1.93897890
19MP0005451_abnormal_body_composition1.90280408
20MP0002138_abnormal_hepatobiliary_system1.87375280
21MP0003091_abnormal_cell_migration1.80379549
22MP0003191_abnormal_cellular_cholesterol1.68596669
23MP0004858_abnormal_nervous_system1.67677237
24MP0005332_abnormal_amino_acid1.64854927
25MP0000609_abnormal_liver_physiology1.64191718
26MP0003186_abnormal_redox_activity1.60126227
27MP0006054_spinal_hemorrhage1.59227139
28MP0003868_abnormal_feces_composition1.59089271
29MP0005058_abnormal_lysosome_morphology1.55449182
30MP0010234_abnormal_vibrissa_follicle1.51429970
31MP0005503_abnormal_tendon_morphology1.50086901
32MP0003950_abnormal_plasma_membrane1.49831179
33MP0005084_abnormal_gallbladder_morpholo1.48509350
34MP0009643_abnormal_urine_homeostasis1.46831322
35MP0005623_abnormal_meninges_morphology1.46823225
36MP0005275_abnormal_skin_tensile1.46079455
37MP0003724_increased_susceptibility_to1.42321384
38MP0005319_abnormal_enzyme/_coenzyme1.42123980
39MP0001849_ear_inflammation1.41162814
40MP0002118_abnormal_lipid_homeostasis1.40811149
41MP0005165_increased_susceptibility_to1.38410955
42MP0001835_abnormal_antigen_presentation1.37247494
43MP0001533_abnormal_skeleton_physiology1.36946352
44MP0003300_gastrointestinal_ulcer1.30020253
45MP0002933_joint_inflammation1.29689571
46MP0002693_abnormal_pancreas_physiology1.29490406
47MP0001944_abnormal_pancreas_morphology1.26973344
48MP0010030_abnormal_orbit_morphology1.26586105
49MP0008260_abnormal_autophagy1.25097673
50MP0000685_abnormal_immune_system1.24050907
51MP0008469_abnormal_protein_level1.22829514
52MP0000003_abnormal_adipose_tissue1.22566600
53MP0009785_altered_susceptibility_to1.22062782
54MP0000767_abnormal_smooth_muscle1.15152964
55MP0003075_altered_response_to1.14971320
56MP0005508_abnormal_skeleton_morphology1.14352531
57MP0000598_abnormal_liver_morphology1.14053632
58MP0004019_abnormal_vitamin_homeostasis1.13910837
59MP0002419_abnormal_innate_immunity1.12513326
60MP0001764_abnormal_homeostasis1.11266404
61MP0002060_abnormal_skin_morphology1.09981283
62MP0005164_abnormal_response_to1.09957568
63MP0000343_altered_response_to1.09249012
64MP0009780_abnormal_chondrocyte_physiolo1.08548038
65MP0005023_abnormal_wound_healing1.08267036
66MP0001542_abnormal_bone_strength1.07896118
67MP0005076_abnormal_cell_differentiation1.07548429
68MP0001845_abnormal_inflammatory_respons1.07223743
69MP0003656_abnormal_erythrocyte_physiolo1.04855948
70MP0003279_aneurysm1.04708451
71MP0005464_abnormal_platelet_physiology1.04323283
72MP0009764_decreased_sensitivity_to1.02445109
73MP0003453_abnormal_keratinocyte_physiol1.02404978
74MP0005025_abnormal_response_to1.01962760
75MP0005501_abnormal_skin_physiology1.01285711
76MP0009053_abnormal_anal_canal1.00501114
77MP0010368_abnormal_lymphatic_system0.99269895
78MP0000678_abnormal_parathyroid_gland0.98626904
79MP0008004_abnormal_stomach_pH0.98443416
80MP0001243_abnormal_dermal_layer0.98015287
81MP0002148_abnormal_hypersensitivity_rea0.97278357
82MP0009763_increased_sensitivity_to0.96816970
83MP0000858_altered_metastatic_potential0.95994730
84MP0009384_cardiac_valve_regurgitation0.95390390
85MP0000751_myopathy0.95114205
86MP0005636_abnormal_mineral_homeostasis0.93709875
87MP0005584_abnormal_enzyme/coenzyme_acti0.93556138
88MP0003795_abnormal_bone_structure0.93164129
89MP0004233_abnormal_muscle_weight0.92313382
90MP0005408_hypopigmentation0.91933712
91MP0002796_impaired_skin_barrier0.91799675
92MP0001790_abnormal_immune_system0.91463678
93MP0005387_immune_system_phenotype0.91463678
94MP0005000_abnormal_immune_tolerance0.91217148
95MP0004947_skin_inflammation0.90062970
96MP0004510_myositis0.90035920
97MP0002078_abnormal_glucose_homeostasis0.89669427
98MP0005390_skeleton_phenotype0.89448063
99MP0002896_abnormal_bone_mineralization0.88934202
100MP0003566_abnormal_cell_adhesion0.88073594
101MP0000681_abnormal_thyroid_gland0.87971035
102MP0003448_altered_tumor_morphology0.86493181
103MP0006082_CNS_inflammation0.86446352
104MP0002166_altered_tumor_susceptibility0.86423188
105MP0000534_abnormal_ureter_morphology0.84544289
106MP0001756_abnormal_urination0.82576588
107MP0005621_abnormal_cell_physiology0.82436051
108MP0002998_abnormal_bone_remodeling0.82249145
109MP0010155_abnormal_intestine_physiology0.82199104
110MP0002928_abnormal_bile_duct0.81564454
111MP0000013_abnormal_adipose_tissue0.80770197
112MP0010352_gastrointestinal_tract_polyps0.80686416
113MP0001853_heart_inflammation0.79800841
114MP0004264_abnormal_extraembryonic_tissu0.79712974
115MP0009333_abnormal_splenocyte_physiolog0.78746287
116MP0001915_intracranial_hemorrhage0.78638945
117MP0009642_abnormal_blood_homeostasis0.78502480
118MP0009278_abnormal_bone_marrow0.78215428
119MP0003959_abnormal_lean_body0.78062125
120MP0000490_abnormal_crypts_of0.76340119
121MP0000249_abnormal_blood_vessel0.75926456
122MP0004782_abnormal_surfactant_physiolog0.75017933
123MP0005670_abnormal_white_adipose0.74211756
124MP0002405_respiratory_system_inflammati0.72825564
125MP0002452_abnormal_antigen_presenting0.72551863
126MP0003123_paternal_imprinting0.72307270
127MP0002723_abnormal_immune_serum0.72235458
128MP0000462_abnormal_digestive_system0.71153663
129MP0003172_abnormal_lysosome_physiology0.70862550
130MP0000733_abnormal_muscle_development0.70402925
131MP0001216_abnormal_epidermal_layer0.70376614
132MP0003942_abnormal_urinary_system0.69818200
133MP0000627_abnormal_mammary_gland0.68650034
134MP0001800_abnormal_humoral_immune0.68574595
135MP0005671_abnormal_response_to0.68346324
136MP0002136_abnormal_kidney_physiology0.67780495
137MP0002295_abnormal_pulmonary_circulatio0.67701308
138MP0009697_abnormal_copulation0.66641279
139MP0001881_abnormal_mammary_gland0.66570016
140MP0001614_abnormal_blood_vessel0.66435798
141MP0005375_adipose_tissue_phenotype0.66414124
142MP0002113_abnormal_skeleton_development0.65952470
143MP0002876_abnormal_thyroid_physiology0.65116342
144MP0005257_abnormal_intraocular_pressure0.64920337
145MP0001348_abnormal_lacrimal_gland0.64558848
146MP0001958_emphysema0.64109101
147MP0005197_abnormal_uvea_morphology0.64087883
148MP0002089_abnormal_postnatal_growth/wei0.63095653
149MP0009931_abnormal_skin_appearance0.62462542

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)4.99491626
2Hypoglycemic coma (HP:0001325)4.25785161
3Abnormality of the intrinsic pathway (HP:0010989)3.96934732
4Deep venous thrombosis (HP:0002625)3.95333475
5Prolonged partial thromboplastin time (HP:0003645)3.92312911
6Abnormality of monocarboxylic acid metabolism (HP:0010996)3.88390887
7Intrahepatic cholestasis (HP:0001406)3.83835379
8Abnormality of the common coagulation pathway (HP:0010990)3.83747301
9Xanthomatosis (HP:0000991)3.78796674
10Hypobetalipoproteinemia (HP:0003563)3.21733221
11Aortic dissection (HP:0002647)3.21324884
12Ankle contracture (HP:0006466)3.15689924
13Beaking of vertebral bodies (HP:0004568)3.15174877
14Hypoglycemic seizures (HP:0002173)3.11165593
15Fat malabsorption (HP:0002630)3.08427256
16Vacuolated lymphocytes (HP:0001922)3.07528411
17Protrusio acetabuli (HP:0003179)3.06607152
18Joint hemorrhage (HP:0005261)2.97365195
19Achilles tendon contracture (HP:0001771)2.94710042
20Spinal rigidity (HP:0003306)2.94424791
21Complement deficiency (HP:0004431)2.91754282
22Abnormality of the Achilles tendon (HP:0005109)2.89516886
23Generalized aminoaciduria (HP:0002909)2.84145500
24Vascular tortuosity (HP:0004948)2.81883859
25Hyperlipoproteinemia (HP:0010980)2.81255838
26Fragile skin (HP:0001030)2.79069785
27Blue sclerae (HP:0000592)2.77863330
28Ketosis (HP:0001946)2.76812178
29Wormian bones (HP:0002645)2.76350823
30Short nail (HP:0001799)2.76202339
31Osteolytic defects of the hand bones (HP:0009699)2.74747765
32Osteolytic defects of the phalanges of the hand (HP:0009771)2.74747765
33Atrophic scars (HP:0001075)2.73323140
34Hyperinsulinemic hypoglycemia (HP:0000825)2.72888504
35Myocardial infarction (HP:0001658)2.72513681
36Abnormality of dentin (HP:0010299)2.72385592
37Cervical subluxation (HP:0003308)2.72179685
38Bladder diverticulum (HP:0000015)2.71855879
39Mucopolysacchariduria (HP:0008155)2.68766009
40Urinary glycosaminoglycan excretion (HP:0003541)2.68766009
41Distal upper limb amyotrophy (HP:0007149)2.68540243
42Upper limb amyotrophy (HP:0009129)2.68540243
43Steatorrhea (HP:0002570)2.67547779
44Arterial tortuosity (HP:0005116)2.66971742
45Vertebral compression fractures (HP:0002953)2.64013427
46Aortic aneurysm (HP:0004942)2.63823863
47Abnormal tarsal ossification (HP:0008369)2.60441614
48Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.59280505
49Hypolipoproteinemia (HP:0010981)2.56005567
50Abnormality of glutamine family amino acid metabolism (HP:0010902)2.54500046
51Symptomatic seizures (HP:0011145)2.53997314
52Abnormality of complement system (HP:0005339)2.52733742
53Follicular hyperkeratosis (HP:0007502)2.50137257
54Ketoacidosis (HP:0001993)2.49559164
55Elbow flexion contracture (HP:0002987)2.45366724
56Abnormality of fatty-acid metabolism (HP:0004359)2.44079608
57Dysostosis multiplex (HP:0000943)2.43154328
58Peritonitis (HP:0002586)2.40880290
59Abnormality of mucopolysaccharide metabolism (HP:0011020)2.40874192
60Abnormality of polysaccharide metabolism (HP:0011012)2.40874192
61Abnormality of glycosaminoglycan metabolism (HP:0004371)2.40874192
62Dilatation of the ascending aorta (HP:0005111)2.40800896
63Abnormality of the distal phalanges of the toes (HP:0010182)2.39790453
64Late onset (HP:0003584)2.39715856
65Abnormality of sulfur amino acid metabolism (HP:0004339)2.38382781
66Premature rupture of membranes (HP:0001788)2.37573637
67Protuberant abdomen (HP:0001538)2.36629164
68Hyperglycemia (HP:0003074)2.36104396
69Abnormality of the acetabulum (HP:0003170)2.35120268
70Hypoalphalipoproteinemia (HP:0003233)2.34871254
71Recurrent gram-negative bacterial infections (HP:0005420)2.33649266
72Mildly elevated creatine phosphokinase (HP:0008180)2.32831810
73Biconcave vertebral bodies (HP:0004586)2.32322606
74Systemic lupus erythematosus (HP:0002725)2.32181794
75Hyperammonemia (HP:0001987)2.31604185
76Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.31536572
77Conjugated hyperbilirubinemia (HP:0002908)2.30597710
78Increased connective tissue (HP:0009025)2.29686006
79Nonimmune hydrops fetalis (HP:0001790)2.28413434
80Abnormal foot bone ossification (HP:0010675)2.27141835
81Distal lower limb amyotrophy (HP:0008944)2.26194676
82Hyperacusis (HP:0010780)2.26160760
83Spondylolisthesis (HP:0003302)2.25598466
84Distal lower limb muscle weakness (HP:0009053)2.25541400
85Hand muscle atrophy (HP:0009130)2.25103981
86Hyperbilirubinemia (HP:0002904)2.24683048
87Soft skin (HP:0000977)2.24322545
88Abnormal delivery (HP:0001787)2.23338794
89Generalized amyotrophy (HP:0003700)2.22806619
90Abnormality of purine metabolism (HP:0004352)2.21761591
91Reduced antithrombin III activity (HP:0001976)2.21521971
92J-shaped sella turcica (HP:0002680)2.21350692
93Abnormal cartilage morphology (HP:0002763)2.20706558
94Cerebral aneurysm (HP:0004944)2.19481546
95Abnormality of nucleobase metabolism (HP:0010932)2.15903489
96Abnormality of methionine metabolism (HP:0010901)2.14810587
97Abnormality of liposaccharide metabolism (HP:0010968)2.14320314
98Abnormality of glycosphingolipid metabolism (HP:0004343)2.14320314
99Abnormality of glycolipid metabolism (HP:0010969)2.14320314
100Pancreatitis (HP:0001733)2.13629464
101Epiphyseal dysplasia (HP:0002656)2.12122844
102Cholecystitis (HP:0001082)2.11752607
103Abnormal gallbladder physiology (HP:0012438)2.11752607
104Slender build (HP:0001533)2.11459125
105Broad face (HP:0000283)2.09304981
106Amyloidosis (HP:0011034)2.08535965
107Epidermoid cyst (HP:0200040)2.08383669
108Genu recurvatum (HP:0002816)2.07390637
109Joint stiffness (HP:0001387)2.07306365
110Reduced subcutaneous adipose tissue (HP:0003758)2.06919989
111Purpura (HP:0000979)2.06351989
112Gingival bleeding (HP:0000225)2.06313840
113Ulnar bowing (HP:0003031)2.05833725
114Disproportionate tall stature (HP:0001519)2.04451552
115Abnormality of aspartate family amino acid metabolism (HP:0010899)2.04277664
116Abnormality of pyrimidine metabolism (HP:0004353)2.04187285
117Aneurysm (HP:0002617)2.02126772
118Thrombocytosis (HP:0001894)2.01313050
119Thoracolumbar scoliosis (HP:0002944)2.00427875
120Mitral stenosis (HP:0001718)2.00095517
121Hemorrhage of the eye (HP:0011885)1.99943545
122Joint laxity (HP:0001388)1.99869394
123Coxa vara (HP:0002812)1.99764285
124Skin nodule (HP:0200036)1.99001972
125Increased mean platelet volume (HP:0011877)1.96668277
126Petechiae (HP:0000967)1.95697703
127Abnormality of carpal bone ossification (HP:0006257)1.95368665
128Increased variability in muscle fiber diameter (HP:0003557)1.94711456
129Menorrhagia (HP:0000132)1.94130612
130Trismus (HP:0000211)1.93322757
131Hypercholesterolemia (HP:0003124)1.92334889
132Hyperparathyroidism (HP:0000843)1.92224730
133Mitral regurgitation (HP:0001653)1.91434830
134Hepatocellular carcinoma (HP:0001402)1.90844462
135Abnormal enzyme/coenzyme activity (HP:0012379)1.90640221
136Glomerulonephritis (HP:0000099)1.90077496
137Hyperextensible skin (HP:0000974)1.89656108
138Cupped ribs (HP:0000887)1.89299837
139Cardiovascular calcification (HP:0011915)1.88265844
140Gout (HP:0001997)1.87745633
141Insulin resistance (HP:0000855)1.87221297
142Elevated alkaline phosphatase (HP:0003155)1.87073461
143Ovoid vertebral bodies (HP:0003300)1.86050648
144Abdominal distention (HP:0003270)1.85471390
145Vascular calcification (HP:0004934)1.85069259
146Entropion (HP:0000621)1.84502598
147Impaired platelet aggregation (HP:0003540)1.83678836
148Abnormal platelet function (HP:0011869)1.83678836
149Abnormality of dicarboxylic acid metabolism (HP:0010995)1.83599351
150Dicarboxylic aciduria (HP:0003215)1.83599351
151Shallow orbits (HP:0000586)1.82494840
152Ectopia lentis (HP:0001083)1.81681863
153Abnormal platelet volume (HP:0011876)1.81140784
154Hyperglycinemia (HP:0002154)1.80932320
155Venous abnormality (HP:0002624)1.80798547
156Flat acetabular roof (HP:0003180)1.80709101
157Abnormality of alkaline phosphatase activity (HP:0004379)1.80657945
158Abnormality of skeletal muscle fiber size (HP:0012084)1.80569723
159Platyspondyly (HP:0000926)1.80353456
160Hydroxyprolinuria (HP:0003080)1.79879341
161Abnormality of proline metabolism (HP:0010907)1.79879341
162Eczematoid dermatitis (HP:0000976)1.78661795
163Thin bony cortex (HP:0002753)1.78302617
164Abnormal ossification of hand bones (HP:0005921)1.77977423
165Long toe (HP:0010511)1.77736374
166Nuclear cataract (HP:0100018)1.77166120
167Abnormality of the pancreatic islet cells (HP:0006476)1.76928627
168Abnormality of endocrine pancreas physiology (HP:0012093)1.76928627
169Natal tooth (HP:0000695)1.76170486
170Back pain (HP:0003418)1.76141333
171Polycythemia (HP:0001901)1.75504072
172Abnormality of transition element cation homeostasis (HP:0011030)1.75414267
173Elevated erythrocyte sedimentation rate (HP:0003565)1.75097959
174Opisthotonus (HP:0002179)1.73291949
175Hyperglycinuria (HP:0003108)1.72491300

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN15.29283726
2BCKDK3.72573936
3FLT32.94390220
4TRIB32.90144537
5TAOK32.62923271
6NME22.36339949
7PIM22.22110382
8IRAK32.21017264
9ICK2.17904012
10INSRR2.13753697
11SIK12.13323400
12MYLK2.11519737
13SMG12.09636927
14PIK3CG2.08872932
15LMTK22.03032022
16LIMK12.02892197
17PKN21.98623350
18PRPF4B1.96717245
19TBK11.92912629
20MAP3K31.89184194
21FGFR41.86205578
22ARAF1.85083356
23PASK1.79662878
24ZAP701.70973531
25MAP3K141.67413169
26EIF2AK31.61411090
27IRAK41.48820408
28JAK31.48326094
29TESK11.45794137
30TYK21.45326904
31RPS6KA41.44505615
32MAPK151.40159547
33PTK61.39098488
34FRK1.32421894
35MAP2K31.29659814
36NEK91.28758784
37EPHA31.26855621
38KDR1.24427633
39KIT1.18753926
40EPHB21.17743829
41SCYL21.13759559
42LRRK21.13399910
43PRKD21.12057898
44MAP4K11.10642479
45EPHA21.07128060
46MAPKAPK31.05031759
47MST1R1.02524149
48ILK1.02271060
49NTRK11.01460042
50MOS0.99655713
51TGFBR20.99611607
52IKBKB0.99192317
53JAK10.97693956
54VRK20.95969906
55MAP2K20.94574298
56BTK0.92874357
57TEC0.91176137
58IKBKE0.91027770
59TRPM70.87707110
60DYRK1B0.86767366
61PTK20.86727883
62DDR20.86332072
63BLK0.86098595
64ABL20.85995356
65STK380.85961003
66BRSK20.84660398
67EIF2AK10.83567491
68MAP3K100.83500561
69MAP3K80.83216246
70NLK0.82123716
71CHUK0.81928354
72PDGFRA0.80812216
73CDC42BPA0.79640288
74IRAK10.78643792
75CDK120.77940564
76ERBB40.77062754
77MAP3K110.76616416
78CSK0.76544288
79EEF2K0.74266718
80CDK80.73106963
81MAP3K120.73006143
82PRKG20.72832995
83STK38L0.71885762
84EPHB10.71638162
85CSF1R0.69788352
86PDPK10.68467747
87LATS10.68121539
88HIPK20.68119930
89RIPK10.67969203
90PTK2B0.67423943
91MET0.65665060
92JAK20.63383978
93TESK20.63377032
94KSR20.62766651
95STK30.61279465
96PIM10.61176165
97LATS20.61167587
98CDK70.60205206
99BRAF0.60202865
100PAK10.60050170
101* MTOR0.58639697
102MAPK110.58459464
103STK160.57714187
104PAK20.55413868
105TGFBR10.53691844
106NUAK10.52433070
107TAOK20.51590243
108RPS6KA20.50877098
109DAPK10.50718011
110ITK0.48189180
111BRSK10.48044418
112STK100.47938049
113DAPK30.47776850
114ROCK20.47430277
115ACVR1B0.45582971
116CDK60.45528821
117PAK40.45500516
118MAP3K10.45183045
119TAOK10.44853358
120CLK10.44375093
121SIK30.42481505
122CAMKK20.41532086
123LYN0.40647509
124DMPK0.39139899
125SYK0.38084842
126IGF1R0.37914941
127MAP3K130.37363308
128MAPKAPK20.36430003
129BMX0.36193681
130ERBB30.36099082
131TTN0.35825053
132GSK3A0.34832369
133STK240.33574714
134MAP3K20.33421552
135CDK90.33280827
136RPS6KB20.33209871
137FGFR30.32748370
138MAP2K10.32678760
139PIK3CA0.32165577
140ABL10.30758602
141TXK0.29412737
142IRAK20.29043550
143RET0.28200543
144SRC0.26979137

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.49343822
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.22199496
3Protein export_Homo sapiens_hsa030602.96186733
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.87709439
5Pentose and glucuronate interconversions_Homo sapiens_hsa000402.29205654
6Tryptophan metabolism_Homo sapiens_hsa003802.28534458
7Complement and coagulation cascades_Homo sapiens_hsa046102.21900859
8Sulfur metabolism_Homo sapiens_hsa009202.18370426
9Folate biosynthesis_Homo sapiens_hsa007902.14598189
10Selenocompound metabolism_Homo sapiens_hsa004502.10759224
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.00630390
12Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.99980588
13Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.97027632
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.95206228
15Fatty acid degradation_Homo sapiens_hsa000711.89589657
16Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.80907452
17Caffeine metabolism_Homo sapiens_hsa002321.79808355
18Drug metabolism - other enzymes_Homo sapiens_hsa009831.73975382
19Peroxisome_Homo sapiens_hsa041461.72778516
20Staphylococcus aureus infection_Homo sapiens_hsa051501.70308418
21Arginine biosynthesis_Homo sapiens_hsa002201.70063514
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.66007092
23Fat digestion and absorption_Homo sapiens_hsa049751.64065263
24Focal adhesion_Homo sapiens_hsa045101.62399570
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.61829132
26Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.61740183
27Chronic myeloid leukemia_Homo sapiens_hsa052201.55865697
28Histidine metabolism_Homo sapiens_hsa003401.55643109
29Vibrio cholerae infection_Homo sapiens_hsa051101.53632266
30Chemical carcinogenesis_Homo sapiens_hsa052041.51805656
31Starch and sucrose metabolism_Homo sapiens_hsa005001.49747110
32Central carbon metabolism in cancer_Homo sapiens_hsa052301.45340784
33Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.44633261
34Nitrogen metabolism_Homo sapiens_hsa009101.43408224
35Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.42678853
36Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.40398274
37Thyroid cancer_Homo sapiens_hsa052161.34382632
38Pancreatic cancer_Homo sapiens_hsa052121.33478767
39Shigellosis_Homo sapiens_hsa051311.29201221
40PPAR signaling pathway_Homo sapiens_hsa033201.28504441
41Other glycan degradation_Homo sapiens_hsa005111.27727172
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.25520933
43Steroid hormone biosynthesis_Homo sapiens_hsa001401.22258601
44beta-Alanine metabolism_Homo sapiens_hsa004101.19792288
45Proteoglycans in cancer_Homo sapiens_hsa052051.19640948
46Amoebiasis_Homo sapiens_hsa051461.19076900
47Phenylalanine metabolism_Homo sapiens_hsa003601.18898337
48Acute myeloid leukemia_Homo sapiens_hsa052211.18513008
49Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.16603157
50Small cell lung cancer_Homo sapiens_hsa052221.14894475
51Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.13121774
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.12941445
53Propanoate metabolism_Homo sapiens_hsa006401.11900317
54Glycosaminoglycan degradation_Homo sapiens_hsa005311.09371315
55Fatty acid metabolism_Homo sapiens_hsa012121.08041303
56AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.05180208
57Retinol metabolism_Homo sapiens_hsa008301.04851510
58N-Glycan biosynthesis_Homo sapiens_hsa005101.04621814
59Lysosome_Homo sapiens_hsa041421.00720178
60Leukocyte transendothelial migration_Homo sapiens_hsa046701.00007097
61Galactose metabolism_Homo sapiens_hsa000520.99762626
62Protein digestion and absorption_Homo sapiens_hsa049740.97927374
63One carbon pool by folate_Homo sapiens_hsa006700.97825933
64Glutathione metabolism_Homo sapiens_hsa004800.97206895
65Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.97120392
66Hepatitis C_Homo sapiens_hsa051600.95596231
67Legionellosis_Homo sapiens_hsa051340.95542806
68Butanoate metabolism_Homo sapiens_hsa006500.94634547
69Tyrosine metabolism_Homo sapiens_hsa003500.93796439
70Steroid biosynthesis_Homo sapiens_hsa001000.93148779
71Non-small cell lung cancer_Homo sapiens_hsa052230.92461204
72ABC transporters_Homo sapiens_hsa020100.91958530
73Regulation of actin cytoskeleton_Homo sapiens_hsa048100.88630458
74Vitamin digestion and absorption_Homo sapiens_hsa049770.88536757
75Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.87796145
76Sulfur relay system_Homo sapiens_hsa041220.87318591
77Arginine and proline metabolism_Homo sapiens_hsa003300.86768886
782-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.83873002
79SNARE interactions in vesicular transport_Homo sapiens_hsa041300.82031858
80Endocytosis_Homo sapiens_hsa041440.81137105
81Pentose phosphate pathway_Homo sapiens_hsa000300.79059954
82Cysteine and methionine metabolism_Homo sapiens_hsa002700.78712656
83Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.78707694
84Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.77997777
85Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.76177219
86Biosynthesis of amino acids_Homo sapiens_hsa012300.75385649
87Salmonella infection_Homo sapiens_hsa051320.75094611
88Endometrial cancer_Homo sapiens_hsa052130.73827159
89Sphingolipid metabolism_Homo sapiens_hsa006000.72597941
90Carbon metabolism_Homo sapiens_hsa012000.72153951
91Renal cell carcinoma_Homo sapiens_hsa052110.71009077
92Cyanoamino acid metabolism_Homo sapiens_hsa004600.70538382
93Pyruvate metabolism_Homo sapiens_hsa006200.69641465
94VEGF signaling pathway_Homo sapiens_hsa043700.68555373
95Hepatitis B_Homo sapiens_hsa051610.67485087
96Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.65996542
97Antigen processing and presentation_Homo sapiens_hsa046120.64035288
98Notch signaling pathway_Homo sapiens_hsa043300.63721044
99Prostate cancer_Homo sapiens_hsa052150.62080948
100Bile secretion_Homo sapiens_hsa049760.59103640
101Leishmaniasis_Homo sapiens_hsa051400.57552155
102Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.57148709
103Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.56480610
104Adherens junction_Homo sapiens_hsa045200.56081442
105Fatty acid elongation_Homo sapiens_hsa000620.54346815
106Malaria_Homo sapiens_hsa051440.53025832
107Glycerolipid metabolism_Homo sapiens_hsa005610.51130931
108NF-kappa B signaling pathway_Homo sapiens_hsa040640.49941735
109Insulin resistance_Homo sapiens_hsa049310.49701131
110PI3K-Akt signaling pathway_Homo sapiens_hsa041510.49126241
111Insulin signaling pathway_Homo sapiens_hsa049100.48492103
112Renin-angiotensin system_Homo sapiens_hsa046140.47004588
113Toll-like receptor signaling pathway_Homo sapiens_hsa046200.46878352
114Pertussis_Homo sapiens_hsa051330.45553555
115Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.44914606
116Phagosome_Homo sapiens_hsa041450.44726511
117Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.44231884
118RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.43949102
119Lysine degradation_Homo sapiens_hsa003100.42505454
120Platelet activation_Homo sapiens_hsa046110.42088604
121Pyrimidine metabolism_Homo sapiens_hsa002400.42048667
122Melanoma_Homo sapiens_hsa052180.41508924
123Glioma_Homo sapiens_hsa052140.40411644
124Thyroid hormone signaling pathway_Homo sapiens_hsa049190.40303506
125Neurotrophin signaling pathway_Homo sapiens_hsa047220.40112389
126Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.39762092
127Metabolic pathways_Homo sapiens_hsa011000.39160238
128Fructose and mannose metabolism_Homo sapiens_hsa000510.37901279
129Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.37215310
130AMPK signaling pathway_Homo sapiens_hsa041520.37116487
131Pancreatic secretion_Homo sapiens_hsa049720.36825318
132Measles_Homo sapiens_hsa051620.34361559
133Intestinal immune network for IgA production_Homo sapiens_hsa046720.34043338
134Apoptosis_Homo sapiens_hsa042100.32592991
135TNF signaling pathway_Homo sapiens_hsa046680.31941967
136ECM-receptor interaction_Homo sapiens_hsa045120.31843264
137Proteasome_Homo sapiens_hsa030500.31174862
138Influenza A_Homo sapiens_hsa051640.26808586
139Bladder cancer_Homo sapiens_hsa052190.25526367
140Toxoplasmosis_Homo sapiens_hsa051450.25503524
141Regulation of autophagy_Homo sapiens_hsa041400.24699824
142Prion diseases_Homo sapiens_hsa050200.23759835
143Adipocytokine signaling pathway_Homo sapiens_hsa049200.23568208
144Arachidonic acid metabolism_Homo sapiens_hsa005900.23018584

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