DAP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that also participates in apoptotic pathways which are initiated by tumor necrosis factor-alpha, Fas ligand, and gamma interferon. This protein potentially binds ATP/GTP and might be a functional partner of the mitoribosomal protein S27. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. Pseudogenes corresponding to this gene are found on chromosomes 1q and 2q. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1polyketide metabolic process (GO:0030638)9.16574014
2doxorubicin metabolic process (GO:0044598)9.16574014
3daunorubicin metabolic process (GO:0044597)9.16574014
4aminoglycoside antibiotic metabolic process (GO:0030647)5.99525930
5protein localization to kinetochore (GO:0034501)5.95283690
6regulation of nuclear cell cycle DNA replication (GO:0033262)5.62122258
7negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)5.44263195
8maintenance of protein location in nucleus (GO:0051457)5.40264510
9DNA replication-dependent nucleosome organization (GO:0034723)5.11460358
10DNA replication-dependent nucleosome assembly (GO:0006335)5.11460358
11mitotic sister chromatid segregation (GO:0000070)5.08849156
12cullin deneddylation (GO:0010388)5.06000732
13regulation of telomere maintenance via telomerase (GO:0032210)5.04419523
14negative regulation of telomerase activity (GO:0051974)4.97189811
15negative regulation of cell cycle G2/M phase transition (GO:1902750)4.96492299
16rRNA transcription (GO:0009303)4.95950301
17regulation of response to osmotic stress (GO:0047484)4.89920291
18regulation of mammary gland epithelial cell proliferation (GO:0033599)4.88367543
19negative regulation of epidermis development (GO:0045683)4.85489111
20DNA replication checkpoint (GO:0000076)4.84479259
21regulation of cilium movement (GO:0003352)4.80950112
22rRNA modification (GO:0000154)4.76117745
23rRNA methylation (GO:0031167)4.73730569
24protein localization to chromosome, centromeric region (GO:0071459)4.67891710
25protein deneddylation (GO:0000338)4.65691657
26histone H4-K8 acetylation (GO:0043982)4.63938010
27histone H4-K5 acetylation (GO:0043981)4.63938010
28histone H4-K12 acetylation (GO:0043983)4.62634523
29proteasome assembly (GO:0043248)4.58988232
30somite rostral/caudal axis specification (GO:0032525)4.57420390
31negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)4.55705428
32ribosomal large subunit biogenesis (GO:0042273)4.53337073
33negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.27582210
34formation of translation preinitiation complex (GO:0001731)4.24512401
35heterochromatin organization (GO:0070828)4.21554213
36mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.17561878
37regulation of translation in response to stress (GO:0043555)4.16430226
38sister chromatid segregation (GO:0000819)4.16076162
39ribosomal small subunit assembly (GO:0000028)4.15116568
40positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.14012637
41negative regulation of telomere maintenance (GO:0032205)4.13448019
42quinone metabolic process (GO:1901661)4.11592040
43ribosome assembly (GO:0042255)4.07800494
44regulation of MHC class I biosynthetic process (GO:0045343)4.07067742
45regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.05987939
46positive regulation of DNA-dependent DNA replication (GO:2000105)4.05334426
47nuclear pore complex assembly (GO:0051292)3.99168659
48ribosome biogenesis (GO:0042254)3.98211394
49anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.95807536
50pseudouridine synthesis (GO:0001522)3.94969681
51negative regulation of epidermal cell differentiation (GO:0045605)3.92365406
52negative regulation of ligase activity (GO:0051352)3.91846777
53negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.91846777
54muscle organ morphogenesis (GO:0048644)3.89001475
55nuclear pore organization (GO:0006999)3.87682956
56regulation of cellular amino acid metabolic process (GO:0006521)3.81539363
57notochord development (GO:0030903)3.78018759
58chromatin assembly (GO:0031497)3.77311918
59cytidine deamination (GO:0009972)3.73525035
60cytidine metabolic process (GO:0046087)3.73525035
61cytidine catabolic process (GO:0006216)3.73525035
62DNA damage response, detection of DNA damage (GO:0042769)3.73083953
63DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.72252025
64intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.71383557
65signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.71383557
66signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.71176907
67signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.71176907
68signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.71176907
69signal transduction involved in DNA integrity checkpoint (GO:0072401)3.67322709
70signal transduction involved in DNA damage checkpoint (GO:0072422)3.67322709
71positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.66892434
72ribosomal small subunit biogenesis (GO:0042274)3.64574328
73DNA replication initiation (GO:0006270)3.60983342
74nucleobase-containing small molecule interconversion (GO:0015949)3.59277448
75signal transduction involved in cell cycle checkpoint (GO:0072395)3.58943343
76SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.57701469
77purine nucleobase biosynthetic process (GO:0009113)3.57265757
78tRNA aminoacylation for protein translation (GO:0006418)3.54710776
79positive regulation of ligase activity (GO:0051351)3.54658830
80maturation of SSU-rRNA (GO:0030490)3.53976106
81DNA unwinding involved in DNA replication (GO:0006268)3.53241131
82folic acid-containing compound biosynthetic process (GO:0009396)3.52957538
83tRNA aminoacylation (GO:0043039)3.51356515
84amino acid activation (GO:0043038)3.51356515
85regulation of translational fidelity (GO:0006450)3.51020274
86cotranslational protein targeting to membrane (GO:0006613)3.50525983
87viral transcription (GO:0019083)3.49237522
88protein targeting to ER (GO:0045047)3.47401238
89ATP synthesis coupled proton transport (GO:0015986)3.45723412
90energy coupled proton transport, down electrochemical gradient (GO:0015985)3.45723412
91translational termination (GO:0006415)3.45200392
92DNA strand elongation involved in DNA replication (GO:0006271)3.44954469
93establishment of integrated proviral latency (GO:0075713)3.44501272
94ribonucleoprotein complex biogenesis (GO:0022613)3.43480315
95nucleoside transmembrane transport (GO:1901642)3.43454129
96translational initiation (GO:0006413)3.39547437
97oxidative phosphorylation (GO:0006119)3.39378725
98nucleobase biosynthetic process (GO:0046112)3.38827919
99establishment of protein localization to endoplasmic reticulum (GO:0072599)3.36889725
100translation (GO:0006412)3.35472533
101protein localization to endoplasmic reticulum (GO:0070972)3.34027008
102GDP-mannose metabolic process (GO:0019673)3.33621923
103DNA strand elongation (GO:0022616)3.33360905
104histone H4-K16 acetylation (GO:0043984)3.32898990
105mitotic chromosome condensation (GO:0007076)3.32769134
106histone arginine methylation (GO:0034969)3.29424965
107transcription from mitochondrial promoter (GO:0006390)3.28354345
108regulation of mitochondrial translation (GO:0070129)3.26413161
109regulation of telomerase activity (GO:0051972)3.24616954
110rRNA processing (GO:0006364)3.24496514
111regulation of apoptotic process involved in morphogenesis (GO:1902337)3.24104339
112DNA duplex unwinding (GO:0032508)3.23714985
113regulation of ubiquitin-protein transferase activity (GO:0051438)3.23674683
114DNA geometric change (GO:0032392)3.21349657
115telomere maintenance via semi-conservative replication (GO:0032201)3.21003286
116microtubule severing (GO:0051013)3.19899706
117cell fate commitment involved in formation of primary germ layer (GO:0060795)3.19642288
118translational elongation (GO:0006414)3.17154279
119regulation of ligase activity (GO:0051340)3.15289924
120protein polyglutamylation (GO:0018095)3.11502327
121regulation of telomere maintenance (GO:0032204)3.09854236
122coenzyme catabolic process (GO:0009109)3.09241492
123termination of RNA polymerase III transcription (GO:0006386)3.08784185
124transcription elongation from RNA polymerase III promoter (GO:0006385)3.08784185
125rRNA metabolic process (GO:0016072)3.08083016
126primitive streak formation (GO:0090009)3.04911268
127maturation of 5.8S rRNA (GO:0000460)3.01492028
128cell cycle G1/S phase transition (GO:0044843)3.00776234
129G1/S transition of mitotic cell cycle (GO:0000082)3.00776234
130phenol-containing compound catabolic process (GO:0019336)3.00284987
131nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.00282924
132regulation of microtubule-based movement (GO:0060632)3.00187735
133respiratory electron transport chain (GO:0022904)3.00072458
134pore complex assembly (GO:0046931)2.98984453
135regulation of posttranscriptional gene silencing (GO:0060147)2.98898052
136regulation of gene silencing by miRNA (GO:0060964)2.98898052
137regulation of gene silencing by RNA (GO:0060966)2.98898052
138tricarboxylic acid cycle (GO:0006099)2.98724366
139protein targeting to mitochondrion (GO:0006626)2.98322940
140spliceosomal snRNP assembly (GO:0000387)2.96696307
141response to dietary excess (GO:0002021)2.96298396
142regulation of double-strand break repair (GO:2000779)2.95510981
143mitochondrial RNA metabolic process (GO:0000959)2.95262094
144electron transport chain (GO:0022900)2.94218009
145cellular component biogenesis (GO:0044085)2.94086766
146antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.94065453
147pteridine-containing compound biosynthetic process (GO:0042559)2.93628518
148positive regulation of cell cycle arrest (GO:0071158)2.92139069
149interferon-gamma production (GO:0032609)2.91459305
150maintenance of protein localization in organelle (GO:0072595)2.90426145
151Golgi transport vesicle coating (GO:0048200)2.86855274
152COPI coating of Golgi vesicle (GO:0048205)2.86855274
153cardiovascular system development (GO:0072358)2.86562994
154viral life cycle (GO:0019058)2.85707299
155negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.84593260
156regulation of cellular amine metabolic process (GO:0033238)2.84265070
157mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.83753431
158regulation of DNA-dependent DNA replication (GO:0090329)2.83306462
159histone H2A acetylation (GO:0043968)2.82681576
160mitotic metaphase plate congression (GO:0007080)2.82162187
161mitotic nuclear envelope disassembly (GO:0007077)2.81895271
162regulation of double-strand break repair via homologous recombination (GO:0010569)2.81137316
163antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.79386854
164DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.79317686
165tetrahydrofolate metabolic process (GO:0046653)2.79265505
166establishment of viral latency (GO:0019043)2.78390473
167folic acid metabolic process (GO:0046655)2.77162672
168telomere maintenance via recombination (GO:0000722)2.76999324
169mRNA stabilization (GO:0048255)2.76345853
170RNA stabilization (GO:0043489)2.76345853
171intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)2.76173335
172establishment of protein localization to mitochondrial membrane (GO:0090151)2.75636576
173regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.75502987
174apoptotic DNA fragmentation (GO:0006309)2.74932860
175hormone catabolic process (GO:0042447)2.74847741
176branching involved in mammary gland duct morphogenesis (GO:0060444)2.73317668
177negative regulation of protein ubiquitination (GO:0031397)2.72175868
178chromosome condensation (GO:0030261)2.71551962
179somatic diversification of immune receptors via somatic mutation (GO:0002566)2.71458386
180somatic hypermutation of immunoglobulin genes (GO:0016446)2.71458386
181maternal placenta development (GO:0001893)2.71155180
182nuclear envelope disassembly (GO:0051081)2.70677119
183DNA conformation change (GO:0071103)2.69059498
184pre-miRNA processing (GO:0031054)2.68432533

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.88549642
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.62595397
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.62595397
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.62595397
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.59065565
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.90155017
7ELF1_17652178_ChIP-ChIP_JURKAT_Human3.35361860
8MYC_18555785_ChIP-Seq_MESCs_Mouse3.31900628
9E2F4_17652178_ChIP-ChIP_JURKAT_Human3.13188102
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.82162598
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.81487536
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.73760986
13NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.67449186
14MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.66045618
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.53376134
16POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.51089397
17ELK1_19687146_ChIP-ChIP_HELA_Human2.44751711
18SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.42203638
19MYC_19030024_ChIP-ChIP_MESCs_Mouse2.42023576
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.41744294
21FOXM1_23109430_ChIP-Seq_U2OS_Human2.39428212
22FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.39117783
23TP63_19390658_ChIP-ChIP_HaCaT_Human2.37272046
24EST1_17652178_ChIP-ChIP_JURKAT_Human2.36826567
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.36599592
26CREB1_15753290_ChIP-ChIP_HEK293T_Human2.36254309
27JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.23561289
28YY1_21170310_ChIP-Seq_MESCs_Mouse2.15401940
29SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.12567063
30TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.12217622
31ETS1_20019798_ChIP-Seq_JURKAT_Human2.04229635
32GABP_17652178_ChIP-ChIP_JURKAT_Human1.98312825
33FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.93512026
34POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.92516723
35POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.88315844
36NANOG_18555785_ChIP-Seq_MESCs_Mouse1.87298225
37* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.85873141
38MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.85339785
39TCF3_18692474_ChIP-Seq_MEFs_Mouse1.82771248
40TCF3_18692474_ChIP-Seq_MESCs_Mouse1.82581504
41NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.82270454
42STAT3_1855785_ChIP-Seq_MESCs_Mouse1.81243907
43NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.78042756
44PADI4_21655091_ChIP-ChIP_MCF-7_Human1.74868329
45HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.72056348
46XRN2_22483619_ChIP-Seq_HELA_Human1.64445986
47* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.64314841
48ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.63401639
49KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.62173891
50CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.60431115
51SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.59849417
52SOX2_18555785_ChIP-Seq_MESCs_Mouse1.58768455
53NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.58742396
54* FOXP3_21729870_ChIP-Seq_TREG_Human1.56239899
55SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.51614354
56IRF1_19129219_ChIP-ChIP_H3396_Human1.51301862
57CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.50309173
58* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.49128733
59ZNF263_19887448_ChIP-Seq_K562_Human1.48367891
60HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.44395895
61THAP11_20581084_ChIP-Seq_MESCs_Mouse1.41065809
62NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.40925740
63VDR_23849224_ChIP-Seq_CD4+_Human1.40166794
64* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.39992495
65GABP_19822575_ChIP-Seq_HepG2_Human1.39408676
66TFEB_21752829_ChIP-Seq_HELA_Human1.39362572
67HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.38892663
68PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.36696727
69TTF2_22483619_ChIP-Seq_HELA_Human1.35284756
70GATA1_22025678_ChIP-Seq_K562_Human1.35067054
71DCP1A_22483619_ChIP-Seq_HELA_Human1.33341887
72MYCN_18555785_ChIP-Seq_MESCs_Mouse1.32630701
73ERG_20887958_ChIP-Seq_HPC-7_Mouse1.31861383
74TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.31366336
75POU5F1_16518401_ChIP-PET_MESCs_Mouse1.29975701
76* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.29968142
77FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.28204172
78NANOG_18692474_ChIP-Seq_MEFs_Mouse1.25729831
79RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24627850
80KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.23538510
81* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.23205332
82DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.22691066
83* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21826014
84ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.18289074
85SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.17262727
86E2F1_17053090_ChIP-ChIP_MCF-7_Human1.17211018
87SOX2_18692474_ChIP-Seq_MEFs_Mouse1.17069536
88KDM5A_27292631_Chip-Seq_BREAST_Human1.16520312
89PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.15608363
90SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.15283263
91CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.14784602
92ZFX_18555785_ChIP-Seq_MESCs_Mouse1.14330949
93TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12229720
94MYC_22102868_ChIP-Seq_BL_Human1.10991900
95PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.10920300
96AR_21909140_ChIP-Seq_LNCAP_Human1.10462903
97NANOG_18692474_ChIP-Seq_MESCs_Mouse1.09837308
98SOX2_18692474_ChIP-Seq_MESCs_Mouse1.09717610
99NANOG_21062744_ChIP-ChIP_HESCs_Human1.09125202
100TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.09104349
101YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.08767267
102CIITA_25753668_ChIP-Seq_RAJI_Human1.08233087
103ESR1_15608294_ChIP-ChIP_MCF-7_Human1.07353420
104* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.07070088
105KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.05570002
106MYC_18940864_ChIP-ChIP_HL60_Human1.05414796
107ELK1_22589737_ChIP-Seq_MCF10A_Human1.05129113
108HIF1A_21447827_ChIP-Seq_MCF-7_Human1.04967905
109NOTCH1_21737748_ChIP-Seq_TLL_Human1.04259773
110HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.00263647
111ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.99819228
112NANOG_16153702_ChIP-ChIP_HESCs_Human0.99534134
113CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.98170126
114SRF_21415370_ChIP-Seq_HL-1_Mouse0.96711531
115MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.96193776
116* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.95963613
117ELF5_23300383_ChIP-Seq_T47D_Human0.95539931
118ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.91255821
119SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.90916657
120YY1_22570637_ChIP-Seq_MALME-3M_Human0.90630256
121SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.90362761
122DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.89918979
123ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.89811053
124* CHD1_26751641_Chip-Seq_LNCaP_Human0.89342397
125SOX17_20123909_ChIP-Seq_XEN_Mouse0.89154143
126* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.89065649
127* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.87164557
128TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.87029083
129TBX5_21415370_ChIP-Seq_HL-1_Mouse0.86987734
130SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.85881613
131CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.85492203
132NANOG_16518401_ChIP-PET_MESCs_Mouse0.85174978
133GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.83987818
134SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.83636415
135CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.83222248
136PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.83074093
137CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.82717740
138* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.82561529
139SRY_22984422_ChIP-ChIP_TESTIS_Rat0.82344394
140EGR1_19374776_ChIP-ChIP_THP-1_Human0.82274022
141E2F1_21310950_ChIP-Seq_MCF-7_Human0.81597047
142CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.78818842
143SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.77576204
144CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.76088143

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003011_delayed_dark_adaptation4.05652089
2MP0006292_abnormal_olfactory_placode4.05551332
3MP0004957_abnormal_blastocyst_morpholog3.94577369
4MP0008057_abnormal_DNA_replication3.67523166
5MP0004264_abnormal_extraembryonic_tissu3.37031113
6MP0005499_abnormal_olfactory_system3.19615237
7MP0005394_taste/olfaction_phenotype3.19615237
8MP0003890_abnormal_embryonic-extraembry3.08810399
9MP0002254_reproductive_system_inflammat2.87075792
10MP0005075_abnormal_melanosome_morpholog2.84815122
11MP0003122_maternal_imprinting2.79433597
12MP0009697_abnormal_copulation2.57176408
13MP0003121_genomic_imprinting2.50609448
14MP0010094_abnormal_chromosome_stability2.49402267
15MP0004858_abnormal_nervous_system2.47448704
16MP0002653_abnormal_ependyma_morphology2.42114667
17MP0003077_abnormal_cell_cycle2.39866733
18MP0002332_abnormal_exercise_endurance2.39634861
19MP0003111_abnormal_nucleus_morphology2.35963038
20MP0003718_maternal_effect2.25470779
21MP0003123_paternal_imprinting2.21173930
22MP0005408_hypopigmentation2.16463863
23MP0003693_abnormal_embryo_hatching2.12303052
24* MP0006035_abnormal_mitochondrial_morpho2.05863035
25MP0001661_extended_life_span2.01512241
26MP0001672_abnormal_embryogenesis/_devel2.00537198
27MP0005380_embryogenesis_phenotype2.00537198
28MP0004147_increased_porphyrin_level1.96612486
29MP0003984_embryonic_growth_retardation1.84159019
30MP0002088_abnormal_embryonic_growth/wei1.84047157
31MP0000372_irregular_coat_pigmentation1.79191345
32MP0008932_abnormal_embryonic_tissue1.79115870
33MP0005451_abnormal_body_composition1.75426795
34MP0000350_abnormal_cell_proliferation1.74962844
35MP0000678_abnormal_parathyroid_gland1.72740418
36MP0008995_early_reproductive_senescence1.67130523
37MP0008058_abnormal_DNA_repair1.66960044
38MP0002127_abnormal_cardiovascular_syste1.65354310
39MP0010352_gastrointestinal_tract_polyps1.63090809
40MP0008789_abnormal_olfactory_epithelium1.58935476
41MP0009333_abnormal_splenocyte_physiolog1.57361186
42MP0005257_abnormal_intraocular_pressure1.57082608
43MP0001730_embryonic_growth_arrest1.56769708
44MP0001293_anophthalmia1.55389040
45MP0005266_abnormal_metabolism1.52949871
46MP0003938_abnormal_ear_development1.52219728
47MP0004133_heterotaxia1.50559162
48MP0001727_abnormal_embryo_implantation1.49605564
49MP0006036_abnormal_mitochondrial_physio1.49353451
50MP0001764_abnormal_homeostasis1.47795019
51MP0002085_abnormal_embryonic_tissue1.47639193
52MP0004233_abnormal_muscle_weight1.46962960
53MP0010234_abnormal_vibrissa_follicle1.45451235
54MP0003705_abnormal_hypodermis_morpholog1.41354566
55MP0002166_altered_tumor_susceptibility1.39113919
56MP0005410_abnormal_fertilization1.38341434
57MP0001849_ear_inflammation1.35802069
58MP0001881_abnormal_mammary_gland1.34725199
59MP0010307_abnormal_tumor_latency1.31869457
60MP0000049_abnormal_middle_ear1.28102591
61MP0008007_abnormal_cellular_replicative1.27958841
62MP0003315_abnormal_perineum_morphology1.27420503
63MP0004808_abnormal_hematopoietic_stem1.25969616
64MP0010030_abnormal_orbit_morphology1.25875682
65* MP0002086_abnormal_extraembryonic_tissu1.24840641
66MP0001873_stomach_inflammation1.24062270
67MP0002396_abnormal_hematopoietic_system1.23927825
68MP0003787_abnormal_imprinting1.23472765
69* MP0002084_abnormal_developmental_patter1.22869052
70MP0003806_abnormal_nucleotide_metabolis1.21276193
71MP0003941_abnormal_skin_development1.21002726
72MP0002932_abnormal_joint_morphology1.16795492
73MP0002277_abnormal_respiratory_mucosa1.16592703
74* MP0002080_prenatal_lethality1.16442500
75MP0000749_muscle_degeneration1.15711368
76MP0008875_abnormal_xenobiotic_pharmacok1.15626969
77MP0002006_tumorigenesis1.14749772
78MP0003137_abnormal_impulse_conducting1.13954433
79* MP0001697_abnormal_embryo_size1.13730148
80MP0003119_abnormal_digestive_system1.13466725
81MP0002092_abnormal_eye_morphology1.12517707
82MP0001853_heart_inflammation1.11705681
83* MP0000313_abnormal_cell_death1.11682330
84MP0003786_premature_aging1.11052816
85MP0005501_abnormal_skin_physiology1.10982166
86MP0004197_abnormal_fetal_growth/weight/1.08462273
87MP0000490_abnormal_crypts_of1.07654815
88MP0002269_muscular_atrophy1.07034232
89MP0002114_abnormal_axial_skeleton1.06980502
90MP0004043_abnormal_pH_regulation1.06309173
91MP0005083_abnormal_biliary_tract1.03243903
92MP0005332_abnormal_amino_acid1.02311069
93MP0003656_abnormal_erythrocyte_physiolo1.01961815
94MP0002751_abnormal_autonomic_nervous1.01561186
95MP0002233_abnormal_nose_morphology1.01493391
96MP0000762_abnormal_tongue_morphology1.01196362
97MP0002163_abnormal_gland_morphology1.00398166
98MP0001348_abnormal_lacrimal_gland1.00183064
99MP0005319_abnormal_enzyme/_coenzyme0.98831101
100MP0001145_abnormal_male_reproductive0.98813831
101MP0008961_abnormal_basal_metabolism0.98257426
102MP0002970_abnormal_white_adipose0.95626186
103MP0000609_abnormal_liver_physiology0.94572572
104MP0004782_abnormal_surfactant_physiolog0.92930204
105MP0002132_abnormal_respiratory_system0.92718625
106MP0002796_impaired_skin_barrier0.92613194
107MP0001545_abnormal_hematopoietic_system0.92167001
108MP0005397_hematopoietic_system_phenotyp0.92167001
109MP0009672_abnormal_birth_weight0.92012268
110MP0001929_abnormal_gametogenesis0.91666706
111MP0008770_decreased_survivor_rate0.89679973
112MP0000428_abnormal_craniofacial_morphol0.89493024
113MP0002210_abnormal_sex_determination0.88706249
114MP0000750_abnormal_muscle_regeneration0.88643655
115MP0000627_abnormal_mammary_gland0.87633949
116* MP0000358_abnormal_cell_content/0.86637783
117MP0008877_abnormal_DNA_methylation0.86283251
118MP0005379_endocrine/exocrine_gland_phen0.86098417
119MP0009840_abnormal_foam_cell0.85613832
120MP0005395_other_phenotype0.84187032
121MP0005670_abnormal_white_adipose0.83658723
122MP0003183_abnormal_peptide_metabolism0.83043711
123MP0003136_yellow_coat_color0.83031434
124MP0001529_abnormal_vocalization0.82226682
125MP0003698_abnormal_male_reproductive0.81908767
126MP0002877_abnormal_melanocyte_morpholog0.81667914
127MP0000432_abnormal_head_morphology0.80974057
128MP0001216_abnormal_epidermal_layer0.80735268
129MP0003186_abnormal_redox_activity0.79781997
130MP0000647_abnormal_sebaceous_gland0.78283065
131MP0003950_abnormal_plasma_membrane0.77946869
132MP0003755_abnormal_palate_morphology0.77783652
133MP0000598_abnormal_liver_morphology0.77762047
134MP0003763_abnormal_thymus_physiology0.77377524
135MP0003935_abnormal_craniofacial_develop0.76404446
136MP0003943_abnormal_hepatobiliary_system0.76355003
137MP0005636_abnormal_mineral_homeostasis0.75470975
138MP0005391_vision/eye_phenotype0.74794283
139MP0003221_abnormal_cardiomyocyte_apopto0.73548338
140MP0005389_reproductive_system_phenotype0.72875850
141MP0005058_abnormal_lysosome_morphology0.70451632
142MP0000427_abnormal_hair_cycle0.67101953
143MP0002019_abnormal_tumor_incidence0.66764495
144MP0003283_abnormal_digestive_organ0.65891176
145MP0005220_abnormal_exocrine_pancreas0.64882922
146MP0003861_abnormal_nervous_system0.64812776
147MP0003646_muscle_fatigue0.64764050
148MP0000653_abnormal_sex_gland0.63161101
149MP0002116_abnormal_craniofacial_bone0.63149852
150MP0000703_abnormal_thymus_morphology0.63082710
151MP0009703_decreased_birth_body0.63047904
152MP0002160_abnormal_reproductive_system0.62796357
153MP0005330_cardiomyopathy0.62768215
154MP0002060_abnormal_skin_morphology0.62277771
155* MP0005384_cellular_phenotype0.61810571
156MP0001919_abnormal_reproductive_system0.61465807
157MP0003937_abnormal_limbs/digits/tail_de0.60135422

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)6.53975443
2Multiple enchondromatosis (HP:0005701)5.26030579
3Hypochromic microcytic anemia (HP:0004840)5.11737030
4Abnormality of the lower motor neuron (HP:0002366)4.60375039
5Hepatoblastoma (HP:0002884)4.43683900
6Ependymoma (HP:0002888)4.32647407
7Acute encephalopathy (HP:0006846)4.25110201
8Acute necrotizing encephalopathy (HP:0006965)4.14875179
9Abnormal mitochondria in muscle tissue (HP:0008316)4.11851849
10Rib fusion (HP:0000902)3.91741415
11Increased CSF lactate (HP:0002490)3.89073897
12Hepatic necrosis (HP:0002605)3.77996811
13Chromosomal breakage induced by crosslinking agents (HP:0003221)3.75343579
14Rhabdomyosarcoma (HP:0002859)3.67578781
15Mitochondrial inheritance (HP:0001427)3.67183078
16Hepatocellular necrosis (HP:0001404)3.66788320
17Nephroblastoma (Wilms tumor) (HP:0002667)3.64281983
18Neoplasm of striated muscle (HP:0009728)3.63519078
19Ragged-red muscle fibers (HP:0003200)3.62879429
20Abnormality of cells of the erythroid lineage (HP:0012130)3.53450992
21Testicular atrophy (HP:0000029)3.51421295
22Embryonal renal neoplasm (HP:0011794)3.46322573
23Reticulocytopenia (HP:0001896)3.38481033
24Abnormal number of erythroid precursors (HP:0012131)3.34795976
25Abnormality of glycolysis (HP:0004366)3.34594749
26Increased serum pyruvate (HP:0003542)3.34594749
27Increased serum lactate (HP:0002151)3.34216569
28Progressive macrocephaly (HP:0004481)3.33243595
29Abnormality of methionine metabolism (HP:0010901)3.33003290
30Chromsome breakage (HP:0040012)3.28390341
31Cerebral edema (HP:0002181)3.27059682
32Generalized aminoaciduria (HP:0002909)3.19308347
33Abnormal lung lobation (HP:0002101)3.14754722
34Increased hepatocellular lipid droplets (HP:0006565)3.09627831
35Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.03919344
36Decreased activity of mitochondrial respiratory chain (HP:0008972)3.03919344
37Rectal fistula (HP:0100590)3.03850328
38Rectovaginal fistula (HP:0000143)3.03850328
39Lactic acidosis (HP:0003128)3.02478773
40Lipid accumulation in hepatocytes (HP:0006561)3.01736469
41Supernumerary spleens (HP:0009799)2.97119188
42Aplasia/Hypoplasia of the fovea (HP:0008060)2.97103804
43Hypoplasia of the fovea (HP:0007750)2.97103804
44Abnormality of the astrocytes (HP:0100707)2.95849961
45Astrocytoma (HP:0009592)2.95849961
46Trismus (HP:0000211)2.91233772
47Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.89367656
48Abnormal protein N-linked glycosylation (HP:0012347)2.89367656
49Abnormal protein glycosylation (HP:0012346)2.89367656
50Abnormal glycosylation (HP:0012345)2.89367656
513-Methylglutaconic aciduria (HP:0003535)2.85294957
52Bifid tongue (HP:0010297)2.83044680
53Meckel diverticulum (HP:0002245)2.82369330
54Microvesicular hepatic steatosis (HP:0001414)2.81294427
55Amyotrophic lateral sclerosis (HP:0007354)2.77264130
56Macrocytic anemia (HP:0001972)2.72538441
57Aplasia/hypoplasia of the humerus (HP:0006507)2.71984070
58Fused cervical vertebrae (HP:0002949)2.71057596
59Abnormality of the anterior horn cell (HP:0006802)2.68178042
60Degeneration of anterior horn cells (HP:0002398)2.68178042
61Hyperinsulinemic hypoglycemia (HP:0000825)2.67764241
62Progressive muscle weakness (HP:0003323)2.67702569
63Respiratory failure (HP:0002878)2.66518517
64Abnormality of the ileum (HP:0001549)2.65055578
65Cholecystitis (HP:0001082)2.63226483
66Abnormal gallbladder physiology (HP:0012438)2.63226483
67Increased intramyocellular lipid droplets (HP:0012240)2.59859325
68Hyperalaninemia (HP:0003348)2.59697054
69Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.59697054
70Abnormality of alanine metabolism (HP:0010916)2.59697054
71Aplasia/Hypoplasia of the uvula (HP:0010293)2.59490247
72Partial duplication of thumb phalanx (HP:0009944)2.59236613
73Premature ovarian failure (HP:0008209)2.58095115
74Tongue fasciculations (HP:0001308)2.57174403
75Abnormality of the salivary glands (HP:0010286)2.56316147
76Intestinal fistula (HP:0100819)2.55766683
77Birth length less than 3rd percentile (HP:0003561)2.53576431
78Anomalous pulmonary venous return (HP:0010772)2.52393361
79Horizontal nystagmus (HP:0000666)2.51847890
80Vaginal fistula (HP:0004320)2.51698440
81Reduced antithrombin III activity (HP:0001976)2.51408897
82Microretrognathia (HP:0000308)2.50501782
83Short humerus (HP:0005792)2.50304513
84Sparse eyelashes (HP:0000653)2.49915644
85Impulsivity (HP:0100710)2.49158067
86Exercise intolerance (HP:0003546)2.48728787
87Aplastic anemia (HP:0001915)2.46133357
88Abnormal cartilage morphology (HP:0002763)2.44993486
89Renal Fanconi syndrome (HP:0001994)2.42632092
90Progressive external ophthalmoplegia (HP:0000590)2.41699228
91Abnormality of aspartate family amino acid metabolism (HP:0010899)2.40650270
92CNS demyelination (HP:0007305)2.39841352
93Lethargy (HP:0001254)2.38216337
94Respiratory difficulties (HP:0002880)2.36831309
95Facial cleft (HP:0002006)2.36638924
96Pancytopenia (HP:0001876)2.33211898
97Muscle fibrillation (HP:0010546)2.32896872
98Hyperammonemia (HP:0001987)2.32786440
99Aplasia/Hypoplasia of the sternum (HP:0006714)2.32546541
100Partial duplication of the phalanx of hand (HP:0009999)2.30583437
101Hyperventilation (HP:0002883)2.29364351
102Glossoptosis (HP:0000162)2.28508122
103Increased muscle lipid content (HP:0009058)2.27171719
104Generalized hypotonia (HP:0001290)2.26216642
105Glioma (HP:0009733)2.25163462
106Abnormality of the fovea (HP:0000493)2.24756444
107Sensory axonal neuropathy (HP:0003390)2.23605324
108Preauricular skin tag (HP:0000384)2.23097994
109Medulloblastoma (HP:0002885)2.22964777
110Duodenal stenosis (HP:0100867)2.21692169
111Small intestinal stenosis (HP:0012848)2.21692169
112Cerebral hypomyelination (HP:0006808)2.21126589
113Atrophy/Degeneration involving motor neurons (HP:0007373)2.20912371
114Angiofibromas (HP:0010615)2.20550482
115Adenoma sebaceum (HP:0009720)2.20550482
116Type I transferrin isoform profile (HP:0003642)2.19871044
117Hypokinesia (HP:0002375)2.19759207
118Neoplasm of head and neck (HP:0012288)2.17584030
119Esophageal neoplasm (HP:0100751)2.17584030
120Shawl scrotum (HP:0000049)2.17014272
121Abnormality of sulfur amino acid metabolism (HP:0004339)2.16687529
122Nausea (HP:0002018)2.14764331
123Hypobetalipoproteinemia (HP:0003563)2.13503906
124Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.10692151
125Abnormality of the pulmonary veins (HP:0011718)2.09687342
126Missing ribs (HP:0000921)2.09253583
127Spastic paraparesis (HP:0002313)2.08915230
128Aplasia/Hypoplasia of the sacrum (HP:0008517)2.08806793
129Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.06385409
130Overlapping toe (HP:0001845)2.06272378
131Abnormality of serum amino acid levels (HP:0003112)2.06254906
132Abnormality of the phalanges of the hallux (HP:0010057)2.06154282
133Malignant neoplasm of the central nervous system (HP:0100836)2.06130388
134Pallor (HP:0000980)2.05680302
135Hypochromic anemia (HP:0001931)2.05517379
136Abnormality of chromosome segregation (HP:0002916)2.04413567
137Leukodystrophy (HP:0002415)2.04275935
138Pendular nystagmus (HP:0012043)2.03124759
139Rough bone trabeculation (HP:0100670)2.02973761
140Abnormality of the preputium (HP:0100587)2.01605683
141Tetraplegia (HP:0002445)2.00322401
142Squamous cell carcinoma (HP:0002860)1.99601878
143Palpitations (HP:0001962)1.96904742
144Secondary amenorrhea (HP:0000869)1.95416489
145Abnormality of reticulocytes (HP:0004312)1.94846546
146Sloping forehead (HP:0000340)1.94220258
147Abnormality of placental membranes (HP:0011409)1.93519762
148Amniotic constriction ring (HP:0009775)1.93519762
149Abnormality of chromosome stability (HP:0003220)1.93140170
150Aplasia/Hypoplasia of the macula (HP:0008059)1.92387559
151Nasolacrimal duct obstruction (HP:0000579)1.89880888
152Skin tags (HP:0010609)1.89851189
153Preauricular pit (HP:0004467)1.89603076
154Periauricular skin pits (HP:0100277)1.89603076
155Abnormality of urine glucose concentration (HP:0011016)1.88976739
156Glycosuria (HP:0003076)1.88976739
157Absent thumb (HP:0009777)1.87974141
158Myelodysplasia (HP:0002863)1.87628226
159Hypoglycemic coma (HP:0001325)1.86802002
160Neoplasm of the adrenal gland (HP:0100631)1.84733388
161Fasciculations (HP:0002380)1.84193317
162Abnormality of aromatic amino acid family metabolism (HP:0004338)1.84083115
163Atresia of the external auditory canal (HP:0000413)1.83882095
164Oral leukoplakia (HP:0002745)1.83866407
165CNS hypomyelination (HP:0003429)1.82920216
166Homocystinuria (HP:0002156)1.82667909
167Abnormality of homocysteine metabolism (HP:0010919)1.82667909
168Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.82227047
169Increased connective tissue (HP:0009025)1.82188022
170Large earlobe (HP:0009748)1.81999452
171Entropion (HP:0000621)1.81680771
172Abnormality of small intestinal villus morphology (HP:0011472)1.81267471
173Villous atrophy (HP:0011473)1.81267471
174Optic disc pallor (HP:0000543)1.80767725
175Posterior subcapsular cataract (HP:0007787)1.80433364
176Rhabdomyolysis (HP:0003201)1.79850007
177Renal cortical cysts (HP:0000803)1.79435903
178Difficulty running (HP:0009046)1.79420113
179Abnormality of the duodenum (HP:0002246)1.78936596
180Abnormality of the labia minora (HP:0012880)1.78409505

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK127.69571618
2GRK54.70486163
3PBK4.06984767
4GRK63.94760141
5ERN13.63015062
6TTK3.18163423
7VRK23.12127261
8ADRBK22.76776457
9GRK12.65914926
10CSF1R2.40320191
11GRK72.25686656
12SCYL22.25683667
13BUB12.25342535
14TYRO32.17991458
15MST1R2.04558472
16TRIM281.96785166
17MAPK71.93333853
18STK101.92115762
19MAP3K121.90362128
20TGFBR21.89992732
21WEE11.89062748
22CDC71.86982343
23MATK1.83930885
24MOS1.80827105
25IRAK31.76360709
26CDK71.76151912
27PDK31.73128648
28PDK41.73128648
29SIK31.71655827
30AKT31.71143594
31PLK11.67087458
32ZAK1.66721613
33WNK11.60768672
34CHEK21.57329281
35PAK41.38779232
36NEK11.31300285
37EPHA21.26194395
38NEK21.22018809
39CAMK41.20311028
40SRPK11.17101191
41PRKG21.16486086
42MAP2K41.12633056
43CHEK11.05112995
44AURKA1.04983976
45ADRBK11.03527916
46BMPR1B1.02891706
47EIF2AK11.01355565
48TESK21.00345679
49TLK10.98153264
50SMG10.94250482
51DAPK10.93475380
52TAF10.91366721
53NTRK10.91288957
54MET0.91158832
55STK40.88152480
56MARK20.85892363
57CLK10.85238464
58ILK0.84853511
59AKT20.82792894
60NME20.81876365
61MKNK10.80518026
62NUAK10.79716795
63PIM20.79497598
64MAP2K60.79465125
65AURKB0.79364914
66PDK20.77407424
67RPS6KB20.75815357
68ACVR1B0.75294853
69FLT30.73712597
70VRK10.72229461
71TESK10.71938661
72BMPR20.71300813
73DYRK30.69606742
74EIF2AK20.69391102
75STK160.67943296
76PRKCI0.67018988
77BCR0.65171919
78CDK20.64201131
79HIPK20.63750465
80MAP3K100.62624454
81LRRK20.62265133
82NME10.61591660
83ALK0.60508211
84PAK10.60232003
85CDK80.59771206
86CDK40.57862356
87TGFBR10.53131956
88RAF10.52724962
89ATM0.51410134
90MAP3K30.48949070
91DYRK20.47946469
92BRAF0.47308484
93MAPK120.46790071
94LATS20.46379081
95MAPKAPK30.45107227
96MKNK20.44462293
97STK30.44376603
98EIF2AK30.44278880
99ERBB40.41748596
100BCKDK0.41541853
101ERBB30.41424361
102MAP3K140.40764740
103ATR0.40746614
104RPS6KA40.39270022
105MYLK0.39176710
106CSNK1E0.38961128
107CDK10.38702061
108BRSK20.34345595
109KSR10.33923607
110MTOR0.33689756
111LMTK20.33190892
112BRSK10.30947137
113TSSK60.30877153
114CDK190.30094118
115IKBKB0.29463143
116CDK150.28214537
117CDK180.27613383
118CSNK1G30.27085823
119CDK11A0.26660846
120CSNK2A10.25979496
121PASK0.25950342
122CSNK2A20.25092711
123MAP2K20.24269519
124MST40.23985605
125CDK90.23686697
126MARK30.23396014
127MAP3K70.22942041
128PRKCG0.22936712
129MUSK0.22552158
130DAPK30.22313407
131EEF2K0.22224240
132MAPKAPK20.21583898
133FGFR30.20921429
134MAP4K20.20608614
135PAK20.20474769
136MAPK100.20380699
137TAOK20.20131279
138CCNB10.19787208
139CSK0.19778476
140GSK3B0.19120463
141CDK140.18579056
142PLK40.17073096
143PLK30.15138502
144MAP3K80.14400588
145PRKACB0.14204440
146MAP3K90.13971292
147MAPK140.13789316
148ICK0.12556677

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.60894782
2Vitamin B6 metabolism_Homo sapiens_hsa007504.54101855
3Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.44500517
4DNA replication_Homo sapiens_hsa030303.34687152
5Ribosome_Homo sapiens_hsa030103.32150210
6Fructose and mannose metabolism_Homo sapiens_hsa000512.99131875
7RNA transport_Homo sapiens_hsa030132.84850308
8Mismatch repair_Homo sapiens_hsa034302.78586169
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.48439608
10Proteasome_Homo sapiens_hsa030502.35643412
11RNA polymerase_Homo sapiens_hsa030202.27479734
12Homologous recombination_Homo sapiens_hsa034402.21821010
13Spliceosome_Homo sapiens_hsa030402.21807618
14Protein export_Homo sapiens_hsa030602.07267003
15Base excision repair_Homo sapiens_hsa034102.05348211
16Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.98962715
17Fanconi anemia pathway_Homo sapiens_hsa034601.97871122
18One carbon pool by folate_Homo sapiens_hsa006701.96854580
19Galactose metabolism_Homo sapiens_hsa000521.93155122
20Arachidonic acid metabolism_Homo sapiens_hsa005901.83350028
21Cell cycle_Homo sapiens_hsa041101.81409325
22mRNA surveillance pathway_Homo sapiens_hsa030151.72261201
23Nucleotide excision repair_Homo sapiens_hsa034201.69825016
24RNA degradation_Homo sapiens_hsa030181.69356879
25Pyrimidine metabolism_Homo sapiens_hsa002401.67829738
26Fatty acid elongation_Homo sapiens_hsa000621.64776487
27Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.64573552
28Basal transcription factors_Homo sapiens_hsa030221.62007482
29Linoleic acid metabolism_Homo sapiens_hsa005911.61948401
30Oxidative phosphorylation_Homo sapiens_hsa001901.53733598
31Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.47433047
32Parkinsons disease_Homo sapiens_hsa050121.47388054
33Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.46828755
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.44638594
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.41957229
36Huntingtons disease_Homo sapiens_hsa050161.41483787
37Carbon metabolism_Homo sapiens_hsa012001.41463088
38Non-homologous end-joining_Homo sapiens_hsa034501.39021085
39Sulfur metabolism_Homo sapiens_hsa009201.29642490
40N-Glycan biosynthesis_Homo sapiens_hsa005101.28387217
41Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.27711139
42Pentose phosphate pathway_Homo sapiens_hsa000301.20798400
43Biosynthesis of amino acids_Homo sapiens_hsa012301.16773749
44Thyroid cancer_Homo sapiens_hsa052161.11825597
45Sulfur relay system_Homo sapiens_hsa041221.11233060
46Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.01359456
47Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.96820319
48Cysteine and methionine metabolism_Homo sapiens_hsa002700.96646734
49Cardiac muscle contraction_Homo sapiens_hsa042600.96265759
50Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.95148994
51Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.88473853
52Folate biosynthesis_Homo sapiens_hsa007900.88219850
53Alzheimers disease_Homo sapiens_hsa050100.84771233
54p53 signaling pathway_Homo sapiens_hsa041150.84042865
55Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.82439335
56Pyruvate metabolism_Homo sapiens_hsa006200.79469205
57Purine metabolism_Homo sapiens_hsa002300.78918953
58Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.77281409
59Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.77119264
60Pentose and glucuronate interconversions_Homo sapiens_hsa000400.71168253
61mTOR signaling pathway_Homo sapiens_hsa041500.68471469
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.67605712
63Peroxisome_Homo sapiens_hsa041460.65703583
64Butanoate metabolism_Homo sapiens_hsa006500.64104254
65Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.62072463
66Fatty acid metabolism_Homo sapiens_hsa012120.60824371
67Metabolic pathways_Homo sapiens_hsa011000.59860128
68Oocyte meiosis_Homo sapiens_hsa041140.58977756
69Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.56970592
70Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.56951529
71Steroid biosynthesis_Homo sapiens_hsa001000.55558614
72Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.55502858
73Other glycan degradation_Homo sapiens_hsa005110.52093691
74Central carbon metabolism in cancer_Homo sapiens_hsa052300.52061141
75Arginine biosynthesis_Homo sapiens_hsa002200.49993842
76Selenocompound metabolism_Homo sapiens_hsa004500.49639520
77Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.49185966
78Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.47637530
79Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44518710
80Ether lipid metabolism_Homo sapiens_hsa005650.44326938
81Hedgehog signaling pathway_Homo sapiens_hsa043400.42969471
82Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.41848310
83Basal cell carcinoma_Homo sapiens_hsa052170.41795496
84Chemical carcinogenesis_Homo sapiens_hsa052040.40657700
85Tyrosine metabolism_Homo sapiens_hsa003500.40623393
86Steroid hormone biosynthesis_Homo sapiens_hsa001400.39532912
87Regulation of autophagy_Homo sapiens_hsa041400.35975786
88Arginine and proline metabolism_Homo sapiens_hsa003300.35409361
89Primary bile acid biosynthesis_Homo sapiens_hsa001200.35241032
90Cyanoamino acid metabolism_Homo sapiens_hsa004600.35130476
91Fatty acid degradation_Homo sapiens_hsa000710.34551220
92Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.34176767
93Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.32376836
94Inositol phosphate metabolism_Homo sapiens_hsa005620.31869086
95Vitamin digestion and absorption_Homo sapiens_hsa049770.30861684
96Phenylalanine metabolism_Homo sapiens_hsa003600.30501313
97Glutathione metabolism_Homo sapiens_hsa004800.29979493
98Caffeine metabolism_Homo sapiens_hsa002320.29569940
99Herpes simplex infection_Homo sapiens_hsa051680.29369148
100Sphingolipid metabolism_Homo sapiens_hsa006000.28953835
101SNARE interactions in vesicular transport_Homo sapiens_hsa041300.28917677
102Glycerophospholipid metabolism_Homo sapiens_hsa005640.28745091
103Drug metabolism - other enzymes_Homo sapiens_hsa009830.28482433
104Transcriptional misregulation in cancer_Homo sapiens_hsa052020.26011842
105Retinol metabolism_Homo sapiens_hsa008300.25616039
106Pathways in cancer_Homo sapiens_hsa052000.24948845
107Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.24805310
108Starch and sucrose metabolism_Homo sapiens_hsa005000.24771873
109Viral carcinogenesis_Homo sapiens_hsa052030.23021979
110Epstein-Barr virus infection_Homo sapiens_hsa051690.22748060
111Propanoate metabolism_Homo sapiens_hsa006400.21810154
112Thyroid hormone signaling pathway_Homo sapiens_hsa049190.21406671
113Legionellosis_Homo sapiens_hsa051340.19413223
114Vibrio cholerae infection_Homo sapiens_hsa051100.19197561
115beta-Alanine metabolism_Homo sapiens_hsa004100.17973794
116Bladder cancer_Homo sapiens_hsa052190.17622589
117Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.17580602
118RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.16777753
119Acute myeloid leukemia_Homo sapiens_hsa052210.15920451
120Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.15445309
121MicroRNAs in cancer_Homo sapiens_hsa052060.14436046
122Ovarian steroidogenesis_Homo sapiens_hsa049130.14218415
123HTLV-I infection_Homo sapiens_hsa051660.14151082
124Hippo signaling pathway_Homo sapiens_hsa043900.13153701
125AMPK signaling pathway_Homo sapiens_hsa041520.11664604
126Regulation of actin cytoskeleton_Homo sapiens_hsa048100.11003102
127Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.08929804
128Systemic lupus erythematosus_Homo sapiens_hsa053220.07777357
129Wnt signaling pathway_Homo sapiens_hsa043100.07772253
130Phospholipase D signaling pathway_Homo sapiens_hsa040720.06985949
131Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.06469540
132Non-small cell lung cancer_Homo sapiens_hsa052230.05578074
133Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.05328699

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