

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645) | 5.19348716 |
| 2 | regulation of interleukin-6 biosynthetic process (GO:0045408) | 5.18393825 |
| 3 | positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141) | 5.14697901 |
| 4 | regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139) | 5.14697901 |
| 5 | regulation of cytokine production involved in inflammatory response (GO:1900015) | 4.90022971 |
| 6 | regulation of interleukin-8 biosynthetic process (GO:0045414) | 4.60602582 |
| 7 | lactate metabolic process (GO:0006089) | 4.44873880 |
| 8 | signal peptide processing (GO:0006465) | 4.30136903 |
| 9 | positive regulation of mitochondrial fission (GO:0090141) | 4.01236865 |
| 10 | pseudouridine synthesis (GO:0001522) | 3.98340700 |
| 11 | DNA damage response, detection of DNA damage (GO:0042769) | 3.95085729 |
| 12 | fucose catabolic process (GO:0019317) | 3.94056941 |
| 13 | L-fucose metabolic process (GO:0042354) | 3.94056941 |
| 14 | L-fucose catabolic process (GO:0042355) | 3.94056941 |
| 15 | regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003339 | 3.86912074 |
| 16 | respiratory chain complex IV assembly (GO:0008535) | 3.82316845 |
| 17 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.79405617 |
| 18 | alpha-beta T cell differentiation involved in immune response (GO:0002293) | 3.73288723 |
| 19 | alpha-beta T cell activation involved in immune response (GO:0002287) | 3.73288723 |
| 20 | T cell differentiation involved in immune response (GO:0002292) | 3.73288723 |
| 21 | negative regulation of thymocyte apoptotic process (GO:0070244) | 3.69197820 |
| 22 | regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:1902235 | 3.65438084 |
| 23 | regulation of vitamin D biosynthetic process (GO:0060556) | 3.65384858 |
| 24 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.63963804 |
| 25 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.63963804 |
| 26 | protein complex biogenesis (GO:0070271) | 3.62998953 |
| 27 | proteasome assembly (GO:0043248) | 3.57077865 |
| 28 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.56694082 |
| 29 | branched-chain amino acid catabolic process (GO:0009083) | 3.56236415 |
| 30 | cytokine biosynthetic process (GO:0042089) | 3.55236244 |
| 31 | maturation of 5.8S rRNA (GO:0000460) | 3.54797614 |
| 32 | cytochrome complex assembly (GO:0017004) | 3.47857560 |
| 33 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.43803962 |
| 34 | NADH dehydrogenase complex assembly (GO:0010257) | 3.43803962 |
| 35 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.43803962 |
| 36 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.43393176 |
| 37 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.43393176 |
| 38 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.43096402 |
| 39 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.43096402 |
| 40 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.43096402 |
| 41 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.37898365 |
| 42 | regulation of interleukin-2 biosynthetic process (GO:0045076) | 3.37646302 |
| 43 | alpha-beta T cell differentiation (GO:0046632) | 3.35569157 |
| 44 | regulation of isotype switching to IgG isotypes (GO:0048302) | 3.35417865 |
| 45 | tRNA methylation (GO:0030488) | 3.33853788 |
| 46 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.32806919 |
| 47 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.25862694 |
| 48 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.25862694 |
| 49 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.24314873 |
| 50 | negative regulation of glucose import (GO:0046325) | 3.24125187 |
| 51 | peptidyl-histidine modification (GO:0018202) | 3.18964191 |
| 52 | positive regulation of keratinocyte differentiation (GO:0045618) | 3.14241362 |
| 53 | positive regulation of antigen receptor-mediated signaling pathway (GO:0050857) | 3.08337095 |
| 54 | negative regulation of T cell apoptotic process (GO:0070233) | 3.03591036 |
| 55 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.02439776 |
| 56 | ribosome assembly (GO:0042255) | 3.00219806 |
| 57 | CD4-positive, alpha-beta T cell differentiation (GO:0043367) | 2.98010452 |
| 58 | valine metabolic process (GO:0006573) | 2.96764798 |
| 59 | regulation of vitamin metabolic process (GO:0030656) | 2.95892913 |
| 60 | GDP-mannose metabolic process (GO:0019673) | 2.93298034 |
| 61 | RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503) | 2.88454802 |
| 62 | regulation of T cell receptor signaling pathway (GO:0050856) | 2.88121817 |
| 63 | cytokine metabolic process (GO:0042107) | 2.86624085 |
| 64 | preassembly of GPI anchor in ER membrane (GO:0016254) | 2.85147241 |
| 65 | negative regulation of ligase activity (GO:0051352) | 2.83464597 |
| 66 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 2.83464597 |
| 67 | regulation of mitochondrial fission (GO:0090140) | 2.82856411 |
| 68 | tRNA processing (GO:0008033) | 2.81828066 |
| 69 | alpha-beta T cell activation (GO:0046631) | 2.79430591 |
| 70 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 2.78949676 |
| 71 | interferon-gamma production (GO:0032609) | 2.77226237 |
| 72 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 2.76540360 |
| 73 | branched-chain amino acid metabolic process (GO:0009081) | 2.75490582 |
| 74 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 2.73917263 |
| 75 | regulation of interleukin-12 biosynthetic process (GO:0045075) | 2.71395597 |
| 76 | rRNA modification (GO:0000154) | 2.71204785 |
| 77 | regulation of cellular amine metabolic process (GO:0033238) | 2.69197898 |
| 78 | ubiquinone biosynthetic process (GO:0006744) | 2.68221651 |
| 79 | histamine secretion (GO:0001821) | 2.67357010 |
| 80 | water-soluble vitamin biosynthetic process (GO:0042364) | 2.67241087 |
| 81 | negative regulation of glucose transport (GO:0010829) | 2.66385123 |
| 82 | CD4-positive, alpha-beta T cell activation (GO:0035710) | 2.66246898 |
| 83 | nucleotide-sugar biosynthetic process (GO:0009226) | 2.64875709 |
| 84 | positive regulation of muscle cell apoptotic process (GO:0010661) | 2.63499847 |
| 85 | organelle disassembly (GO:1903008) | 2.62191719 |
| 86 | positive regulation of cell cycle arrest (GO:0071158) | 2.62142126 |
| 87 | DNA deamination (GO:0045006) | 2.61371461 |
| 88 | negative regulation of oligodendrocyte differentiation (GO:0048715) | 2.60364985 |
| 89 | ubiquinone metabolic process (GO:0006743) | 2.58077990 |
| 90 | behavioral response to nicotine (GO:0035095) | 2.56394621 |
| 91 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 2.56330686 |
| 92 | negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254) | 2.55929491 |
| 93 | regulation of interleukin-17 production (GO:0032660) | 2.55895911 |
| 94 | negative regulation of interleukin-17 production (GO:0032700) | 2.54660636 |
| 95 | regulation of protein kinase A signaling (GO:0010738) | 2.54590746 |
| 96 | regulation of neurotransmitter uptake (GO:0051580) | 2.54162349 |
| 97 | protein deneddylation (GO:0000338) | 2.53745472 |
| 98 | regulation of interferon-gamma-mediated signaling pathway (GO:0060334) | 2.53153528 |
| 99 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 2.51826849 |
| 100 | T-helper cell differentiation (GO:0042093) | 2.51465431 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 7.44571452 |
| 2 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 4.28863728 |
| 3 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 3.98101627 |
| 4 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 3.76636546 |
| 5 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.67844492 |
| 6 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.37916137 |
| 7 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 3.25953105 |
| 8 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 3.19404459 |
| 9 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 2.95578794 |
| 10 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 2.93825694 |
| 11 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.86230643 |
| 12 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.57765686 |
| 13 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 2.57131191 |
| 14 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.50897435 |
| 15 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.41132626 |
| 16 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 2.39940511 |
| 17 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.34385678 |
| 18 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 2.32899051 |
| 19 | IGF1R_20145208_ChIP-Seq_DFB_Human | 2.19092566 |
| 20 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 2.00718954 |
| 21 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.99017335 |
| 22 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.94129866 |
| 23 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.84309608 |
| 24 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 1.81400108 |
| 25 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 1.79214970 |
| 26 | VDR_22108803_ChIP-Seq_LS180_Human | 1.78760793 |
| 27 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.77827186 |
| 28 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.73725755 |
| 29 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.70852781 |
| 30 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.68807202 |
| 31 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.66022396 |
| 32 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 1.61494055 |
| 33 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.61084658 |
| 34 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.51302285 |
| 35 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.49976872 |
| 36 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.49636583 |
| 37 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 1.47208987 |
| 38 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.45605399 |
| 39 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.39124393 |
| 40 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.37460610 |
| 41 | EWS_26573619_Chip-Seq_HEK293_Human | 1.35267975 |
| 42 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.35200431 |
| 43 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.35043669 |
| 44 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.30710880 |
| 45 | BCAT_22108803_ChIP-Seq_LS180_Human | 1.30211325 |
| 46 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.27908374 |
| 47 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.24770019 |
| 48 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.24160033 |
| 49 | GATA3_26560356_Chip-Seq_TH2_Human | 1.20893318 |
| 50 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 1.18553049 |
| 51 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.18143108 |
| 52 | GATA3_27048872_Chip-Seq_THYMUS_Human | 1.14345450 |
| 53 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.14180185 |
| 54 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.12928458 |
| 55 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.12482527 |
| 56 | NCOR_22424771_ChIP-Seq_293T_Human | 1.11440660 |
| 57 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.10802032 |
| 58 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.10802032 |
| 59 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 1.10332687 |
| 60 | SALL4_22934838_ChIP-ChIP_CD34+_Human | 1.09469417 |
| 61 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 1.08559099 |
| 62 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 1.06448402 |
| 63 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.06124641 |
| 64 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.05169456 |
| 65 | MYB_26560356_Chip-Seq_TH2_Human | 1.03869147 |
| 66 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.01907377 |
| 67 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.01251600 |
| 68 | KDM5A_27292631_Chip-Seq_BREAST_Human | 0.98290562 |
| 69 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 0.97489426 |
| 70 | P300_19829295_ChIP-Seq_ESCs_Human | 0.97024108 |
| 71 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 0.93139037 |
| 72 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 0.92983589 |
| 73 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 0.92431452 |
| 74 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 0.91965150 |
| 75 | AR_21572438_ChIP-Seq_LNCaP_Human | 0.91962707 |
| 76 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 0.90507764 |
| 77 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 0.90190085 |
| 78 | CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse | 0.89026784 |
| 79 | NANOG_19829295_ChIP-Seq_ESCs_Human | 0.88017096 |
| 80 | SOX2_19829295_ChIP-Seq_ESCs_Human | 0.88017096 |
| 81 | CEBPA_26348894_ChIP-Seq_LIVER_Mouse | 0.87970932 |
| 82 | TCF4_22108803_ChIP-Seq_LS180_Human | 0.87579627 |
| 83 | MYC_18940864_ChIP-ChIP_HL60_Human | 0.87528799 |
| 84 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.87440192 |
| 85 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 0.87303709 |
| 86 | AR_20517297_ChIP-Seq_VCAP_Human | 0.87110626 |
| 87 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.86353760 |
| 88 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 0.86123495 |
| 89 | SPI1_23547873_ChIP-Seq_NB4_Human | 0.86021665 |
| 90 | RUNX1_27457419_Chip-Seq_LIVER_Mouse | 0.85626015 |
| 91 | FUS_26573619_Chip-Seq_HEK293_Human | 0.85139726 |
| 92 | TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.84693790 |
| 93 | ETV2_25802403_ChIP-Seq_MESCs_Mouse | 0.83696696 |
| 94 | ETV1_20927104_ChIP-Seq_GIST48_Human | 0.83692501 |
| 95 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 0.83586914 |
| 96 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 0.83268539 |
| 97 | ERG_20517297_ChIP-Seq_VCAP_Human | 0.82854891 |
| 98 | P300_18555785_Chip-Seq_ESCs_Mouse | 0.81751595 |
| 99 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 0.81571302 |
| 100 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 0.81571302 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003950_abnormal_plasma_membrane | 4.21016307 |
| 2 | MP0001986_abnormal_taste_sensitivity | 3.91891615 |
| 3 | MP0005671_abnormal_response_to | 3.54395240 |
| 4 | MP0001984_abnormal_olfaction | 3.07728336 |
| 5 | MP0000372_irregular_coat_pigmentation | 3.02223765 |
| 6 | MP0001873_stomach_inflammation | 2.88732375 |
| 7 | MP0009785_altered_susceptibility_to | 2.58975696 |
| 8 | MP0008872_abnormal_physiological_respon | 2.58588450 |
| 9 | MP0005451_abnormal_body_composition | 2.53971924 |
| 10 | MP0003656_abnormal_erythrocyte_physiolo | 2.37376994 |
| 11 | MP0002653_abnormal_ependyma_morphology | 2.24159858 |
| 12 | MP0001529_abnormal_vocalization | 2.23622819 |
| 13 | MP0001835_abnormal_antigen_presentation | 2.19015210 |
| 14 | MP0002822_catalepsy | 2.14713833 |
| 15 | MP0002638_abnormal_pupillary_reflex | 2.10866179 |
| 16 | MP0002277_abnormal_respiratory_mucosa | 2.08113195 |
| 17 | MP0005387_immune_system_phenotype | 2.04972731 |
| 18 | MP0001790_abnormal_immune_system | 2.04972731 |
| 19 | MP0005000_abnormal_immune_tolerance | 1.96479266 |
| 20 | MP0005551_abnormal_eye_electrophysiolog | 1.87521528 |
| 21 | MP0010155_abnormal_intestine_physiology | 1.84162331 |
| 22 | MP0001849_ear_inflammation | 1.77445334 |
| 23 | MP0008875_abnormal_xenobiotic_pharmacok | 1.74763028 |
| 24 | MP0003806_abnormal_nucleotide_metabolis | 1.74156426 |
| 25 | MP0002933_joint_inflammation | 1.65784425 |
| 26 | MP0008789_abnormal_olfactory_epithelium | 1.59179915 |
| 27 | MP0005084_abnormal_gallbladder_morpholo | 1.57575815 |
| 28 | MP0001800_abnormal_humoral_immune | 1.56716895 |
| 29 | MP0009764_decreased_sensitivity_to | 1.50975456 |
| 30 | MP0004147_increased_porphyrin_level | 1.50399810 |
| 31 | MP0002735_abnormal_chemical_nociception | 1.47568940 |
| 32 | MP0009333_abnormal_splenocyte_physiolog | 1.44264197 |
| 33 | MP0006035_abnormal_mitochondrial_morpho | 1.43515473 |
| 34 | MP0002102_abnormal_ear_morphology | 1.41422144 |
| 35 | MP0006036_abnormal_mitochondrial_physio | 1.33361621 |
| 36 | MP0003787_abnormal_imprinting | 1.31787268 |
| 37 | MP0001764_abnormal_homeostasis | 1.31632008 |
| 38 | MP0003186_abnormal_redox_activity | 1.31629305 |
| 39 | MP0004084_abnormal_cardiac_muscle | 1.30753017 |
| 40 | MP0002234_abnormal_pharynx_morphology | 1.28187589 |
| 41 | MP0004142_abnormal_muscle_tone | 1.28179935 |
| 42 | MP0002148_abnormal_hypersensitivity_rea | 1.27774190 |
| 43 | MP0004782_abnormal_surfactant_physiolog | 1.27675059 |
| 44 | MP0002876_abnormal_thyroid_physiology | 1.27650097 |
| 45 | MP0002723_abnormal_immune_serum | 1.27497531 |
| 46 | MP0009697_abnormal_copulation | 1.21121218 |
| 47 | MP0005499_abnormal_olfactory_system | 1.20840159 |
| 48 | MP0005394_taste/olfaction_phenotype | 1.20840159 |
| 49 | MP0001666_abnormal_nutrient_absorption | 1.18524604 |
| 50 | MP0008877_abnormal_DNA_methylation | 1.16011264 |
| 51 | MP0003195_calcinosis | 1.12687882 |
| 52 | MP0000685_abnormal_immune_system | 1.11870449 |
| 53 | MP0002452_abnormal_antigen_presenting | 1.08592183 |
| 54 | MP0000490_abnormal_crypts_of | 1.07384053 |
| 55 | MP0004145_abnormal_muscle_electrophysio | 1.06776116 |
| 56 | MP0002282_abnormal_trachea_morphology | 1.03219984 |
| 57 | MP0001968_abnormal_touch/_nociception | 1.02402303 |
| 58 | MP0001881_abnormal_mammary_gland | 1.00284387 |
| 59 | MP0002420_abnormal_adaptive_immunity | 1.00105968 |
| 60 | MP0002693_abnormal_pancreas_physiology | 0.97891560 |
| 61 | MP0001905_abnormal_dopamine_level | 0.96987275 |
| 62 | MP0001819_abnormal_immune_cell | 0.96872583 |
| 63 | MP0005319_abnormal_enzyme/_coenzyme | 0.96014749 |
| 64 | MP0005332_abnormal_amino_acid | 0.95464026 |
| 65 | MP0004924_abnormal_behavior | 0.94142927 |
| 66 | MP0005386_behavior/neurological_phenoty | 0.94142927 |
| 67 | MP0005253_abnormal_eye_physiology | 0.92867376 |
| 68 | MP0000689_abnormal_spleen_morphology | 0.91936409 |
| 69 | MP0005410_abnormal_fertilization | 0.90284890 |
| 70 | MP0003252_abnormal_bile_duct | 0.89978725 |
| 71 | MP0004215_abnormal_myocardial_fiber | 0.89291189 |
| 72 | MP0001845_abnormal_inflammatory_respons | 0.89270589 |
| 73 | MP0001756_abnormal_urination | 0.88596709 |
| 74 | MP0000371_diluted_coat_color | 0.88078075 |
| 75 | MP0002009_preneoplasia | 0.87637070 |
| 76 | MP0000427_abnormal_hair_cycle | 0.86120777 |
| 77 | MP0001502_abnormal_circadian_rhythm | 0.84497764 |
| 78 | MP0005075_abnormal_melanosome_morpholog | 0.82807474 |
| 79 | MP0002736_abnormal_nociception_after | 0.82247764 |
| 80 | MP0004036_abnormal_muscle_relaxation | 0.82220825 |
| 81 | MP0005025_abnormal_response_to | 0.81876614 |
| 82 | MP0002166_altered_tumor_susceptibility | 0.81473947 |
| 83 | MP0002090_abnormal_vision | 0.79383372 |
| 84 | MP0008961_abnormal_basal_metabolism | 0.77118832 |
| 85 | MP0005365_abnormal_bile_salt | 0.75864475 |
| 86 | MP0008873_increased_physiological_sensi | 0.75652863 |
| 87 | MP0005083_abnormal_biliary_tract | 0.75538166 |
| 88 | MP0001243_abnormal_dermal_layer | 0.74509988 |
| 89 | MP0008007_abnormal_cellular_replicative | 0.73110419 |
| 90 | MP0002398_abnormal_bone_marrow | 0.72813744 |
| 91 | MP0003646_muscle_fatigue | 0.72214756 |
| 92 | MP0000015_abnormal_ear_pigmentation | 0.71995429 |
| 93 | MP0001663_abnormal_digestive_system | 0.71935491 |
| 94 | MP0001919_abnormal_reproductive_system | 0.70953533 |
| 95 | MP0002722_abnormal_immune_system | 0.68888154 |
| 96 | MP0005310_abnormal_salivary_gland | 0.68843892 |
| 97 | MP0005584_abnormal_enzyme/coenzyme_acti | 0.68834229 |
| 98 | MP0003011_delayed_dark_adaptation | 0.67663006 |
| 99 | MP0008058_abnormal_DNA_repair | 0.66773342 |
| 100 | MP0005377_hearing/vestibular/ear_phenot | 0.66647669 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Abnormality of the pons (HP:0007361) | 5.45975042 |
| 2 | Recurrent cutaneous fungal infections (HP:0011370) | 4.74973256 |
| 3 | Chronic mucocutaneous candidiasis (HP:0002728) | 4.74973256 |
| 4 | 3-Methylglutaconic aciduria (HP:0003535) | 4.27987320 |
| 5 | Abnormality of B cell number (HP:0010975) | 3.60033220 |
| 6 | B lymphocytopenia (HP:0010976) | 3.58647299 |
| 7 | Hypoplasia of the pons (HP:0012110) | 3.50977541 |
| 8 | Microvesicular hepatic steatosis (HP:0001414) | 3.22537546 |
| 9 | Cheilitis (HP:0100825) | 3.22350912 |
| 10 | Stomatitis (HP:0010280) | 3.20956739 |
| 11 | Hypoproteinemia (HP:0003075) | 2.99020412 |
| 12 | Spastic paraparesis (HP:0002313) | 2.88479242 |
| 13 | Parakeratosis (HP:0001036) | 2.87945853 |
| 14 | Type I transferrin isoform profile (HP:0003642) | 2.86455102 |
| 15 | Severe combined immunodeficiency (HP:0004430) | 2.80202868 |
| 16 | Hepatocellular necrosis (HP:0001404) | 2.79980991 |
| 17 | Increased CSF lactate (HP:0002490) | 2.77108195 |
| 18 | Agammaglobulinemia (HP:0004432) | 2.75540767 |
| 19 | Hyperglycinuria (HP:0003108) | 2.74991769 |
| 20 | Duplicated collecting system (HP:0000081) | 2.74862708 |
| 21 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.73379799 |
| 22 | Mitochondrial inheritance (HP:0001427) | 2.72196133 |
| 23 | Recurrent fungal infections (HP:0002841) | 2.72007106 |
| 24 | Acute necrotizing encephalopathy (HP:0006965) | 2.69259594 |
| 25 | Megaloblastic anemia (HP:0001889) | 2.62412332 |
| 26 | Abnormality of T cell physiology (HP:0011840) | 2.61650240 |
| 27 | Increased serum pyruvate (HP:0003542) | 2.61463691 |
| 28 | IgG deficiency (HP:0004315) | 2.61298684 |
| 29 | Abnormality of the renal collecting system (HP:0004742) | 2.60725928 |
| 30 | Oral leukoplakia (HP:0002745) | 2.60711977 |
| 31 | Acute encephalopathy (HP:0006846) | 2.56650964 |
| 32 | Chronic sinusitis (HP:0011109) | 2.54997689 |
| 33 | Hypothermia (HP:0002045) | 2.51052945 |
| 34 | Testicular atrophy (HP:0000029) | 2.49738693 |
| 35 | Hyperglycinemia (HP:0002154) | 2.49450559 |
| 36 | Increased serum lactate (HP:0002151) | 2.45245237 |
| 37 | Hemoptysis (HP:0002105) | 2.42047986 |
| 38 | Nonimmune hydrops fetalis (HP:0001790) | 2.40792022 |
| 39 | Abnormal mitochondria in muscle tissue (HP:0008316) | 2.37644966 |
| 40 | Elevated erythrocyte sedimentation rate (HP:0003565) | 2.36197523 |
| 41 | Hepatic necrosis (HP:0002605) | 2.34606201 |
| 42 | Congenital stationary night blindness (HP:0007642) | 2.34344394 |
| 43 | Abnormality of the anterior horn cell (HP:0006802) | 2.33533368 |
| 44 | Degeneration of anterior horn cells (HP:0002398) | 2.33533368 |
| 45 | Abnormality of glycolysis (HP:0004366) | 2.32962677 |
| 46 | Combined immunodeficiency (HP:0005387) | 2.28867307 |
| 47 | Abnormality of serum amino acid levels (HP:0003112) | 2.28337181 |
| 48 | Optic neuritis (HP:0100653) | 2.28102426 |
| 49 | Retrobulbar optic neuritis (HP:0100654) | 2.28102426 |
| 50 | Abnormality of T cells (HP:0002843) | 2.26436955 |
| 51 | Autoimmune thrombocytopenia (HP:0001973) | 2.25908995 |
| 52 | Pancreatic cysts (HP:0001737) | 2.21015358 |
| 53 | Autoimmune hemolytic anemia (HP:0001890) | 2.20842832 |
| 54 | Abnormality of glycine metabolism (HP:0010895) | 2.20532167 |
| 55 | Abnormality of serine family amino acid metabolism (HP:0010894) | 2.20532167 |
| 56 | Lipid accumulation in hepatocytes (HP:0006561) | 2.17632039 |
| 57 | Reduced antithrombin III activity (HP:0001976) | 2.16301075 |
| 58 | Thyroiditis (HP:0100646) | 2.11940875 |
| 59 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.11739728 |
| 60 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.11739728 |
| 61 | Atrophy/Degeneration involving motor neurons (HP:0007373) | 2.10351721 |
| 62 | Cortical visual impairment (HP:0100704) | 2.09997494 |
| 63 | Progressive macrocephaly (HP:0004481) | 2.09033133 |
| 64 | Amyotrophic lateral sclerosis (HP:0007354) | 2.08962922 |
| 65 | Mesangial abnormality (HP:0001966) | 2.06789242 |
| 66 | Cerebral edema (HP:0002181) | 2.05412252 |
| 67 | Exercise intolerance (HP:0003546) | 2.04072610 |
| 68 | Abnormality of transition element cation homeostasis (HP:0011030) | 2.03959509 |
| 69 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.02551213 |
| 70 | Attenuation of retinal blood vessels (HP:0007843) | 2.00835373 |
| 71 | Aplastic anemia (HP:0001915) | 2.00330711 |
| 72 | Molar tooth sign on MRI (HP:0002419) | 1.98799131 |
| 73 | Abnormality of midbrain morphology (HP:0002418) | 1.98799131 |
| 74 | Concave nail (HP:0001598) | 1.98299838 |
| 75 | Large for gestational age (HP:0001520) | 1.98202439 |
| 76 | Lactic acidosis (HP:0003128) | 1.98140500 |
| 77 | Abolished electroretinogram (ERG) (HP:0000550) | 1.94187854 |
| 78 | Abnormal rod and cone electroretinograms (HP:0008323) | 1.89352522 |
| 79 | Spontaneous abortion (HP:0005268) | 1.89274174 |
| 80 | Increased hepatocellular lipid droplets (HP:0006565) | 1.89073638 |
| 81 | IgA deficiency (HP:0002720) | 1.88082765 |
| 82 | Abnormal protein N-linked glycosylation (HP:0012347) | 1.87929101 |
| 83 | Abnormal protein glycosylation (HP:0012346) | 1.87929101 |
| 84 | Abnormal glycosylation (HP:0012345) | 1.87929101 |
| 85 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 1.87929101 |
| 86 | Aplasia/Hypoplasia involving the musculature (HP:0001460) | 1.86313082 |
| 87 | Acute hepatic failure (HP:0006554) | 1.85623676 |
| 88 | Skin rash (HP:0000988) | 1.85363164 |
| 89 | Abnormality of placental membranes (HP:0011409) | 1.85088718 |
| 90 | Amniotic constriction ring (HP:0009775) | 1.85088718 |
| 91 | Ependymoma (HP:0002888) | 1.84542946 |
| 92 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 1.83934261 |
| 93 | Bile duct proliferation (HP:0001408) | 1.83017251 |
| 94 | Abnormal biliary tract physiology (HP:0012439) | 1.83017251 |
| 95 | Optic disc pallor (HP:0000543) | 1.78254643 |
| 96 | Pancytopenia (HP:0001876) | 1.78055249 |
| 97 | Pulmonary infiltrates (HP:0002113) | 1.77277322 |
| 98 | Widely spaced teeth (HP:0000687) | 1.73943012 |
| 99 | Thrombocytosis (HP:0001894) | 1.73793225 |
| 100 | Aplasia of the musculature (HP:0100854) | 1.73768963 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TRIM28 | 4.00839150 |
| 2 | EIF2AK3 | 3.55642788 |
| 3 | TXK | 3.30950348 |
| 4 | FLT3 | 3.14253982 |
| 5 | SIK3 | 3.04335974 |
| 6 | BRSK2 | 3.03783686 |
| 7 | CAMKK2 | 3.02875398 |
| 8 | PIM2 | 2.90445085 |
| 9 | TSSK6 | 2.54093376 |
| 10 | STK24 | 2.37924002 |
| 11 | NEK1 | 2.32203027 |
| 12 | STK38L | 2.15199041 |
| 13 | EIF2AK1 | 2.13572388 |
| 14 | PKN2 | 2.00508145 |
| 15 | BCR | 1.85646379 |
| 16 | NUAK1 | 1.75472215 |
| 17 | TEC | 1.74633304 |
| 18 | BCKDK | 1.54751894 |
| 19 | PINK1 | 1.52260823 |
| 20 | MAP4K1 | 1.49615929 |
| 21 | MST4 | 1.47870677 |
| 22 | VRK2 | 1.47223680 |
| 23 | ITK | 1.34437518 |
| 24 | MAP2K6 | 1.34098632 |
| 25 | TAOK3 | 1.32703047 |
| 26 | PAK3 | 1.29743482 |
| 27 | IRAK4 | 1.27519257 |
| 28 | EIF2AK2 | 1.21769117 |
| 29 | ADRBK2 | 1.20897795 |
| 30 | KDR | 1.15697096 |
| 31 | GRK1 | 1.14562816 |
| 32 | BMPR1B | 1.12400749 |
| 33 | BTK | 1.12331871 |
| 34 | TBK1 | 1.11483153 |
| 35 | PLK3 | 1.09924307 |
| 36 | PIK3CG | 1.07601501 |
| 37 | PRKCQ | 1.05629743 |
| 38 | FRK | 1.01729996 |
| 39 | MAP3K5 | 0.99129720 |
| 40 | MAP2K7 | 0.98223251 |
| 41 | DYRK1B | 0.94060651 |
| 42 | BRSK1 | 0.93887643 |
| 43 | KIT | 0.91327005 |
| 44 | ZAK | 0.86149007 |
| 45 | CAMKK1 | 0.85260654 |
| 46 | WNK3 | 0.85166027 |
| 47 | SRPK1 | 0.85137897 |
| 48 | MAP4K2 | 0.84729593 |
| 49 | SYK | 0.82425818 |
| 50 | VRK1 | 0.81480776 |
| 51 | NME1 | 0.80476947 |
| 52 | TLK1 | 0.73716734 |
| 53 | STK3 | 0.73047784 |
| 54 | MAP3K14 | 0.71545443 |
| 55 | IRAK2 | 0.70514346 |
| 56 | PAK6 | 0.67051749 |
| 57 | CSF1R | 0.66423000 |
| 58 | KSR1 | 0.66127549 |
| 59 | NME2 | 0.65260759 |
| 60 | AKT3 | 0.61941075 |
| 61 | IRAK1 | 0.60118503 |
| 62 | STK39 | 0.59200859 |
| 63 | PKN1 | 0.56750434 |
| 64 | OXSR1 | 0.56090760 |
| 65 | LATS1 | 0.56005192 |
| 66 | DYRK2 | 0.55922358 |
| 67 | ADRBK1 | 0.54059025 |
| 68 | MAPK13 | 0.53738971 |
| 69 | DAPK1 | 0.52399683 |
| 70 | PASK | 0.52204919 |
| 71 | IKBKE | 0.51917394 |
| 72 | INSRR | 0.51764081 |
| 73 | PIM1 | 0.48734596 |
| 74 | FGFR1 | 0.48344913 |
| 75 | GRK5 | 0.48201785 |
| 76 | HCK | 0.47186032 |
| 77 | CCNB1 | 0.47092395 |
| 78 | MAPKAPK3 | 0.46795782 |
| 79 | LYN | 0.46503105 |
| 80 | ERBB3 | 0.46483577 |
| 81 | PRKAA1 | 0.45906353 |
| 82 | CSNK1A1 | 0.43881205 |
| 83 | TESK2 | 0.43833157 |
| 84 | CSNK1G1 | 0.43248845 |
| 85 | ABL1 | 0.43027223 |
| 86 | IGF1R | 0.42751992 |
| 87 | MAP3K4 | 0.42325606 |
| 88 | CAMK2D | 0.41369982 |
| 89 | BMPR2 | 0.40506805 |
| 90 | ACVR1B | 0.40491525 |
| 91 | TNK2 | 0.38993735 |
| 92 | CSNK1G3 | 0.38924127 |
| 93 | CAMK2A | 0.38032933 |
| 94 | MINK1 | 0.36129228 |
| 95 | ABL2 | 0.36112671 |
| 96 | LCK | 0.35453567 |
| 97 | CSNK1A1L | 0.33833469 |
| 98 | PRKCE | 0.33176047 |
| 99 | RAF1 | 0.31805359 |
| 100 | MET | 0.30893149 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 5.43708448 |
| 2 | Protein export_Homo sapiens_hsa03060 | 4.62652273 |
| 3 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 3.02624098 |
| 4 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 2.84818020 |
| 5 | Primary immunodeficiency_Homo sapiens_hsa05340 | 2.79214054 |
| 6 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.24026541 |
| 7 | Regulation of autophagy_Homo sapiens_hsa04140 | 2.17532464 |
| 8 | Phototransduction_Homo sapiens_hsa04744 | 2.10828208 |
| 9 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 2.05384850 |
| 10 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 2.03533275 |
| 11 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 2.00735810 |
| 12 | Basal transcription factors_Homo sapiens_hsa03022 | 1.98271579 |
| 13 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.97959931 |
| 14 | Parkinsons disease_Homo sapiens_hsa05012 | 1.95854849 |
| 15 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.92033812 |
| 16 | RNA polymerase_Homo sapiens_hsa03020 | 1.82012379 |
| 17 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.75107359 |
| 18 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.71051309 |
| 19 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.70496964 |
| 20 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.69410040 |
| 21 | RNA degradation_Homo sapiens_hsa03018 | 1.58891588 |
| 22 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.57737368 |
| 23 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.55284549 |
| 24 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 1.50118869 |
| 25 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.49729825 |
| 26 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 1.45704411 |
| 27 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.44677072 |
| 28 | Allograft rejection_Homo sapiens_hsa05330 | 1.33554415 |
| 29 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.32883918 |
| 30 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.30358503 |
| 31 | Circadian rhythm_Homo sapiens_hsa04710 | 1.29873836 |
| 32 | Huntingtons disease_Homo sapiens_hsa05016 | 1.27174133 |
| 33 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.26941917 |
| 34 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.17360479 |
| 35 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 1.16989806 |
| 36 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.14642131 |
| 37 | Peroxisome_Homo sapiens_hsa04146 | 1.14325912 |
| 38 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.06003418 |
| 39 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.03999354 |
| 40 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.01552323 |
| 41 | Alzheimers disease_Homo sapiens_hsa05010 | 0.97354037 |
| 42 | Carbon metabolism_Homo sapiens_hsa01200 | 0.96224390 |
| 43 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.93456655 |
| 44 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.93180327 |
| 45 | RNA transport_Homo sapiens_hsa03013 | 0.92614668 |
| 46 | Purine metabolism_Homo sapiens_hsa00230 | 0.91831248 |
| 47 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 0.91347340 |
| 48 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.90222530 |
| 49 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.88035731 |
| 50 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.87099375 |
| 51 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.86051505 |
| 52 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.82930000 |
| 53 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.82732706 |
| 54 | Olfactory transduction_Homo sapiens_hsa04740 | 0.82710641 |
| 55 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.81313479 |
| 56 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.80589538 |
| 57 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.78167796 |
| 58 | Homologous recombination_Homo sapiens_hsa03440 | 0.74609444 |
| 59 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.73076150 |
| 60 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.72693968 |
| 61 | Metabolic pathways_Homo sapiens_hsa01100 | 0.71527328 |
| 62 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.68767364 |
| 63 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.68458123 |
| 64 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.68143097 |
| 65 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.67849086 |
| 66 | Measles_Homo sapiens_hsa05162 | 0.67773760 |
| 67 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.66667161 |
| 68 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.60992925 |
| 69 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.60072556 |
| 70 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.58450449 |
| 71 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.58152681 |
| 72 | Asthma_Homo sapiens_hsa05310 | 0.57600450 |
| 73 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.56506375 |
| 74 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.55139295 |
| 75 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.53890751 |
| 76 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.53726267 |
| 77 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.51551418 |
| 78 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.51224368 |
| 79 | Spliceosome_Homo sapiens_hsa03040 | 0.51187788 |
| 80 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.50726097 |
| 81 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.44755384 |
| 82 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.43564372 |
| 83 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.41454941 |
| 84 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.41330573 |
| 85 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.38728166 |
| 86 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.37270849 |
| 87 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.35693176 |
| 88 | Nucleotide excision repair_Homo sapiens_hsa03420 | 0.33916499 |
| 89 | Nicotine addiction_Homo sapiens_hsa05033 | 0.33908804 |
| 90 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.33730638 |
| 91 | Base excision repair_Homo sapiens_hsa03410 | 0.33097136 |
| 92 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.31455196 |
| 93 | Malaria_Homo sapiens_hsa05144 | 0.28196456 |
| 94 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.26655726 |
| 95 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.26499626 |
| 96 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.25264429 |
| 97 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.23908307 |
| 98 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.23483804 |
| 99 | Retinol metabolism_Homo sapiens_hsa00830 | 0.22439396 |
| 100 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.22290822 |

