DAP3P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)5.19348716
2regulation of interleukin-6 biosynthetic process (GO:0045408)5.18393825
3positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)5.14697901
4regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)5.14697901
5regulation of cytokine production involved in inflammatory response (GO:1900015)4.90022971
6regulation of interleukin-8 biosynthetic process (GO:0045414)4.60602582
7lactate metabolic process (GO:0006089)4.44873880
8signal peptide processing (GO:0006465)4.30136903
9positive regulation of mitochondrial fission (GO:0090141)4.01236865
10pseudouridine synthesis (GO:0001522)3.98340700
11DNA damage response, detection of DNA damage (GO:0042769)3.95085729
12fucose catabolic process (GO:0019317)3.94056941
13L-fucose metabolic process (GO:0042354)3.94056941
14L-fucose catabolic process (GO:0042355)3.94056941
15regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033393.86912074
16respiratory chain complex IV assembly (GO:0008535)3.82316845
17regulation of cellular amino acid metabolic process (GO:0006521)3.79405617
18alpha-beta T cell differentiation involved in immune response (GO:0002293)3.73288723
19alpha-beta T cell activation involved in immune response (GO:0002287)3.73288723
20T cell differentiation involved in immune response (GO:0002292)3.73288723
21negative regulation of thymocyte apoptotic process (GO:0070244)3.69197820
22regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.65438084
23regulation of vitamin D biosynthetic process (GO:0060556)3.65384858
24RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.63963804
25tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.63963804
26protein complex biogenesis (GO:0070271)3.62998953
27proteasome assembly (GO:0043248)3.57077865
28DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.56694082
29branched-chain amino acid catabolic process (GO:0009083)3.56236415
30cytokine biosynthetic process (GO:0042089)3.55236244
31maturation of 5.8S rRNA (GO:0000460)3.54797614
32cytochrome complex assembly (GO:0017004)3.47857560
33mitochondrial respiratory chain complex I assembly (GO:0032981)3.43803962
34NADH dehydrogenase complex assembly (GO:0010257)3.43803962
35mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.43803962
36intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.43393176
37signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.43393176
38signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.43096402
39signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.43096402
40signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.43096402
41mitochondrial respiratory chain complex assembly (GO:0033108)3.37898365
42regulation of interleukin-2 biosynthetic process (GO:0045076)3.37646302
43alpha-beta T cell differentiation (GO:0046632)3.35569157
44regulation of isotype switching to IgG isotypes (GO:0048302)3.35417865
45tRNA methylation (GO:0030488)3.33853788
46negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.32806919
47signal transduction involved in DNA damage checkpoint (GO:0072422)3.25862694
48signal transduction involved in DNA integrity checkpoint (GO:0072401)3.25862694
49signal transduction involved in cell cycle checkpoint (GO:0072395)3.24314873
50negative regulation of glucose import (GO:0046325)3.24125187
51peptidyl-histidine modification (GO:0018202)3.18964191
52positive regulation of keratinocyte differentiation (GO:0045618)3.14241362
53positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.08337095
54negative regulation of T cell apoptotic process (GO:0070233)3.03591036
55positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.02439776
56ribosome assembly (GO:0042255)3.00219806
57CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.98010452
58valine metabolic process (GO:0006573)2.96764798
59regulation of vitamin metabolic process (GO:0030656)2.95892913
60GDP-mannose metabolic process (GO:0019673)2.93298034
61RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.88454802
62regulation of T cell receptor signaling pathway (GO:0050856)2.88121817
63cytokine metabolic process (GO:0042107)2.86624085
64preassembly of GPI anchor in ER membrane (GO:0016254)2.85147241
65negative regulation of ligase activity (GO:0051352)2.83464597
66negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.83464597
67regulation of mitochondrial fission (GO:0090140)2.82856411
68tRNA processing (GO:0008033)2.81828066
69alpha-beta T cell activation (GO:0046631)2.79430591
70DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.78949676
71interferon-gamma production (GO:0032609)2.77226237
72antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.76540360
73branched-chain amino acid metabolic process (GO:0009081)2.75490582
74regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.73917263
75regulation of interleukin-12 biosynthetic process (GO:0045075)2.71395597
76rRNA modification (GO:0000154)2.71204785
77regulation of cellular amine metabolic process (GO:0033238)2.69197898
78ubiquinone biosynthetic process (GO:0006744)2.68221651
79histamine secretion (GO:0001821)2.67357010
80water-soluble vitamin biosynthetic process (GO:0042364)2.67241087
81negative regulation of glucose transport (GO:0010829)2.66385123
82CD4-positive, alpha-beta T cell activation (GO:0035710)2.66246898
83nucleotide-sugar biosynthetic process (GO:0009226)2.64875709
84positive regulation of muscle cell apoptotic process (GO:0010661)2.63499847
85organelle disassembly (GO:1903008)2.62191719
86positive regulation of cell cycle arrest (GO:0071158)2.62142126
87DNA deamination (GO:0045006)2.61371461
88negative regulation of oligodendrocyte differentiation (GO:0048715)2.60364985
89ubiquinone metabolic process (GO:0006743)2.58077990
90behavioral response to nicotine (GO:0035095)2.56394621
91exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.56330686
92negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)2.55929491
93regulation of interleukin-17 production (GO:0032660)2.55895911
94negative regulation of interleukin-17 production (GO:0032700)2.54660636
95regulation of protein kinase A signaling (GO:0010738)2.54590746
96regulation of neurotransmitter uptake (GO:0051580)2.54162349
97protein deneddylation (GO:0000338)2.53745472
98regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.53153528
99nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.51826849
100T-helper cell differentiation (GO:0042093)2.51465431

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse7.44571452
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.28863728
3ELF1_17652178_ChIP-ChIP_JURKAT_Human3.98101627
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.76636546
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.67844492
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.37916137
7FLI1_27457419_Chip-Seq_LIVER_Mouse3.25953105
8BP1_19119308_ChIP-ChIP_Hs578T_Human3.19404459
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.95578794
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.93825694
11ZNF274_21170338_ChIP-Seq_K562_Hela2.86230643
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.57765686
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.57131191
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.50897435
15VDR_23849224_ChIP-Seq_CD4+_Human2.41132626
16PCGF2_27294783_Chip-Seq_ESCs_Mouse2.39940511
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.34385678
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.32899051
19IGF1R_20145208_ChIP-Seq_DFB_Human2.19092566
20IRF8_21731497_ChIP-ChIP_J774_Mouse2.00718954
21SRF_21415370_ChIP-Seq_HL-1_Mouse1.99017335
22NOTCH1_21737748_ChIP-Seq_TLL_Human1.94129866
23CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.84309608
24CREB1_15753290_ChIP-ChIP_HEK293T_Human1.81400108
25PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.79214970
26VDR_22108803_ChIP-Seq_LS180_Human1.78760793
27PADI4_21655091_ChIP-ChIP_MCF-7_Human1.77827186
28FOXP3_21729870_ChIP-Seq_TREG_Human1.73725755
29IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.70852781
30PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.68807202
31ELK1_19687146_ChIP-ChIP_HELA_Human1.66022396
32CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.61494055
33CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.61084658
34SMAD_19615063_ChIP-ChIP_OVARY_Human1.51302285
35IRF1_19129219_ChIP-ChIP_H3396_Human1.49976872
36FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.49636583
37IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.47208987
38GABP_19822575_ChIP-Seq_HepG2_Human1.45605399
39POU3F2_20337985_ChIP-ChIP_501MEL_Human1.39124393
40HOXB4_20404135_ChIP-ChIP_EML_Mouse1.37460610
41EWS_26573619_Chip-Seq_HEK293_Human1.35267975
42PCGF2_27294783_Chip-Seq_NPCs_Mouse1.35200431
43SUZ12_27294783_Chip-Seq_NPCs_Mouse1.35043669
44DCP1A_22483619_ChIP-Seq_HELA_Human1.30710880
45BCAT_22108803_ChIP-Seq_LS180_Human1.30211325
46NFE2_27457419_Chip-Seq_LIVER_Mouse1.27908374
47EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.24770019
48TP53_22573176_ChIP-Seq_HFKS_Human1.24160033
49GATA3_26560356_Chip-Seq_TH2_Human1.20893318
50PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.18553049
51ER_23166858_ChIP-Seq_MCF-7_Human1.18143108
52GATA3_27048872_Chip-Seq_THYMUS_Human1.14345450
53ZFP57_27257070_Chip-Seq_ESCs_Mouse1.14180185
54MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.12928458
55SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.12482527
56NCOR_22424771_ChIP-Seq_293T_Human1.11440660
57CBP_20019798_ChIP-Seq_JUKART_Human1.10802032
58IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.10802032
59PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.10332687
60SALL4_22934838_ChIP-ChIP_CD34+_Human1.09469417
61EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.08559099
62CRX_20693478_ChIP-Seq_RETINA_Mouse1.06448402
63UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.06124641
64CTBP2_25329375_ChIP-Seq_LNCAP_Human1.05169456
65MYB_26560356_Chip-Seq_TH2_Human1.03869147
66GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.01907377
67TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01251600
68KDM5A_27292631_Chip-Seq_BREAST_Human0.98290562
69MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.97489426
70P300_19829295_ChIP-Seq_ESCs_Human0.97024108
71AUTS2_25519132_ChIP-Seq_293T-REX_Human0.93139037
72EZH2_27294783_Chip-Seq_NPCs_Mouse0.92983589
73STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.92431452
74ELK1_22589737_ChIP-Seq_MCF10A_Human0.91965150
75AR_21572438_ChIP-Seq_LNCaP_Human0.91962707
76MYC_18358816_ChIP-ChIP_MESCs_Mouse0.90507764
77YY1_21170310_ChIP-Seq_MESCs_Mouse0.90190085
78CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.89026784
79NANOG_19829295_ChIP-Seq_ESCs_Human0.88017096
80SOX2_19829295_ChIP-Seq_ESCs_Human0.88017096
81CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.87970932
82TCF4_22108803_ChIP-Seq_LS180_Human0.87579627
83MYC_18940864_ChIP-ChIP_HL60_Human0.87528799
84FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.87440192
85KLF5_20875108_ChIP-Seq_MESCs_Mouse0.87303709
86AR_20517297_ChIP-Seq_VCAP_Human0.87110626
87FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86353760
88STAT4_19710469_ChIP-ChIP_TH1__Mouse0.86123495
89SPI1_23547873_ChIP-Seq_NB4_Human0.86021665
90RUNX1_27457419_Chip-Seq_LIVER_Mouse0.85626015
91FUS_26573619_Chip-Seq_HEK293_Human0.85139726
92TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.84693790
93ETV2_25802403_ChIP-Seq_MESCs_Mouse0.83696696
94ETV1_20927104_ChIP-Seq_GIST48_Human0.83692501
95SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.83586914
96STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.83268539
97ERG_20517297_ChIP-Seq_VCAP_Human0.82854891
98P300_18555785_Chip-Seq_ESCs_Mouse0.81751595
99FOXA1_25329375_ChIP-Seq_VCAP_Human0.81571302
100FOXA1_27270436_Chip-Seq_PROSTATE_Human0.81571302

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003950_abnormal_plasma_membrane4.21016307
2MP0001986_abnormal_taste_sensitivity3.91891615
3MP0005671_abnormal_response_to3.54395240
4MP0001984_abnormal_olfaction3.07728336
5MP0000372_irregular_coat_pigmentation3.02223765
6MP0001873_stomach_inflammation2.88732375
7MP0009785_altered_susceptibility_to2.58975696
8MP0008872_abnormal_physiological_respon2.58588450
9MP0005451_abnormal_body_composition2.53971924
10MP0003656_abnormal_erythrocyte_physiolo2.37376994
11MP0002653_abnormal_ependyma_morphology2.24159858
12MP0001529_abnormal_vocalization2.23622819
13MP0001835_abnormal_antigen_presentation2.19015210
14MP0002822_catalepsy2.14713833
15MP0002638_abnormal_pupillary_reflex2.10866179
16MP0002277_abnormal_respiratory_mucosa2.08113195
17MP0005387_immune_system_phenotype2.04972731
18MP0001790_abnormal_immune_system2.04972731
19MP0005000_abnormal_immune_tolerance1.96479266
20MP0005551_abnormal_eye_electrophysiolog1.87521528
21MP0010155_abnormal_intestine_physiology1.84162331
22MP0001849_ear_inflammation1.77445334
23MP0008875_abnormal_xenobiotic_pharmacok1.74763028
24MP0003806_abnormal_nucleotide_metabolis1.74156426
25MP0002933_joint_inflammation1.65784425
26MP0008789_abnormal_olfactory_epithelium1.59179915
27MP0005084_abnormal_gallbladder_morpholo1.57575815
28MP0001800_abnormal_humoral_immune1.56716895
29MP0009764_decreased_sensitivity_to1.50975456
30MP0004147_increased_porphyrin_level1.50399810
31MP0002735_abnormal_chemical_nociception1.47568940
32MP0009333_abnormal_splenocyte_physiolog1.44264197
33MP0006035_abnormal_mitochondrial_morpho1.43515473
34MP0002102_abnormal_ear_morphology1.41422144
35MP0006036_abnormal_mitochondrial_physio1.33361621
36MP0003787_abnormal_imprinting1.31787268
37MP0001764_abnormal_homeostasis1.31632008
38MP0003186_abnormal_redox_activity1.31629305
39MP0004084_abnormal_cardiac_muscle1.30753017
40MP0002234_abnormal_pharynx_morphology1.28187589
41MP0004142_abnormal_muscle_tone1.28179935
42MP0002148_abnormal_hypersensitivity_rea1.27774190
43MP0004782_abnormal_surfactant_physiolog1.27675059
44MP0002876_abnormal_thyroid_physiology1.27650097
45MP0002723_abnormal_immune_serum1.27497531
46MP0009697_abnormal_copulation1.21121218
47MP0005499_abnormal_olfactory_system1.20840159
48MP0005394_taste/olfaction_phenotype1.20840159
49MP0001666_abnormal_nutrient_absorption1.18524604
50MP0008877_abnormal_DNA_methylation1.16011264
51MP0003195_calcinosis1.12687882
52MP0000685_abnormal_immune_system1.11870449
53MP0002452_abnormal_antigen_presenting1.08592183
54MP0000490_abnormal_crypts_of1.07384053
55MP0004145_abnormal_muscle_electrophysio1.06776116
56MP0002282_abnormal_trachea_morphology1.03219984
57MP0001968_abnormal_touch/_nociception1.02402303
58MP0001881_abnormal_mammary_gland1.00284387
59MP0002420_abnormal_adaptive_immunity1.00105968
60MP0002693_abnormal_pancreas_physiology0.97891560
61MP0001905_abnormal_dopamine_level0.96987275
62MP0001819_abnormal_immune_cell0.96872583
63MP0005319_abnormal_enzyme/_coenzyme0.96014749
64MP0005332_abnormal_amino_acid0.95464026
65MP0004924_abnormal_behavior0.94142927
66MP0005386_behavior/neurological_phenoty0.94142927
67MP0005253_abnormal_eye_physiology0.92867376
68MP0000689_abnormal_spleen_morphology0.91936409
69MP0005410_abnormal_fertilization0.90284890
70MP0003252_abnormal_bile_duct0.89978725
71MP0004215_abnormal_myocardial_fiber0.89291189
72MP0001845_abnormal_inflammatory_respons0.89270589
73MP0001756_abnormal_urination0.88596709
74MP0000371_diluted_coat_color0.88078075
75MP0002009_preneoplasia0.87637070
76MP0000427_abnormal_hair_cycle0.86120777
77MP0001502_abnormal_circadian_rhythm0.84497764
78MP0005075_abnormal_melanosome_morpholog0.82807474
79MP0002736_abnormal_nociception_after0.82247764
80MP0004036_abnormal_muscle_relaxation0.82220825
81MP0005025_abnormal_response_to0.81876614
82MP0002166_altered_tumor_susceptibility0.81473947
83MP0002090_abnormal_vision0.79383372
84MP0008961_abnormal_basal_metabolism0.77118832
85MP0005365_abnormal_bile_salt0.75864475
86MP0008873_increased_physiological_sensi0.75652863
87MP0005083_abnormal_biliary_tract0.75538166
88MP0001243_abnormal_dermal_layer0.74509988
89MP0008007_abnormal_cellular_replicative0.73110419
90MP0002398_abnormal_bone_marrow0.72813744
91MP0003646_muscle_fatigue0.72214756
92MP0000015_abnormal_ear_pigmentation0.71995429
93MP0001663_abnormal_digestive_system0.71935491
94MP0001919_abnormal_reproductive_system0.70953533
95MP0002722_abnormal_immune_system0.68888154
96MP0005310_abnormal_salivary_gland0.68843892
97MP0005584_abnormal_enzyme/coenzyme_acti0.68834229
98MP0003011_delayed_dark_adaptation0.67663006
99MP0008058_abnormal_DNA_repair0.66773342
100MP0005377_hearing/vestibular/ear_phenot0.66647669

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the pons (HP:0007361)5.45975042
2Recurrent cutaneous fungal infections (HP:0011370)4.74973256
3Chronic mucocutaneous candidiasis (HP:0002728)4.74973256
43-Methylglutaconic aciduria (HP:0003535)4.27987320
5Abnormality of B cell number (HP:0010975)3.60033220
6B lymphocytopenia (HP:0010976)3.58647299
7Hypoplasia of the pons (HP:0012110)3.50977541
8Microvesicular hepatic steatosis (HP:0001414)3.22537546
9Cheilitis (HP:0100825)3.22350912
10Stomatitis (HP:0010280)3.20956739
11Hypoproteinemia (HP:0003075)2.99020412
12Spastic paraparesis (HP:0002313)2.88479242
13Parakeratosis (HP:0001036)2.87945853
14Type I transferrin isoform profile (HP:0003642)2.86455102
15Severe combined immunodeficiency (HP:0004430)2.80202868
16Hepatocellular necrosis (HP:0001404)2.79980991
17Increased CSF lactate (HP:0002490)2.77108195
18Agammaglobulinemia (HP:0004432)2.75540767
19Hyperglycinuria (HP:0003108)2.74991769
20Duplicated collecting system (HP:0000081)2.74862708
21Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.73379799
22Mitochondrial inheritance (HP:0001427)2.72196133
23Recurrent fungal infections (HP:0002841)2.72007106
24Acute necrotizing encephalopathy (HP:0006965)2.69259594
25Megaloblastic anemia (HP:0001889)2.62412332
26Abnormality of T cell physiology (HP:0011840)2.61650240
27Increased serum pyruvate (HP:0003542)2.61463691
28IgG deficiency (HP:0004315)2.61298684
29Abnormality of the renal collecting system (HP:0004742)2.60725928
30Oral leukoplakia (HP:0002745)2.60711977
31Acute encephalopathy (HP:0006846)2.56650964
32Chronic sinusitis (HP:0011109)2.54997689
33Hypothermia (HP:0002045)2.51052945
34Testicular atrophy (HP:0000029)2.49738693
35Hyperglycinemia (HP:0002154)2.49450559
36Increased serum lactate (HP:0002151)2.45245237
37Hemoptysis (HP:0002105)2.42047986
38Nonimmune hydrops fetalis (HP:0001790)2.40792022
39Abnormal mitochondria in muscle tissue (HP:0008316)2.37644966
40Elevated erythrocyte sedimentation rate (HP:0003565)2.36197523
41Hepatic necrosis (HP:0002605)2.34606201
42Congenital stationary night blindness (HP:0007642)2.34344394
43Abnormality of the anterior horn cell (HP:0006802)2.33533368
44Degeneration of anterior horn cells (HP:0002398)2.33533368
45Abnormality of glycolysis (HP:0004366)2.32962677
46Combined immunodeficiency (HP:0005387)2.28867307
47Abnormality of serum amino acid levels (HP:0003112)2.28337181
48Optic neuritis (HP:0100653)2.28102426
49Retrobulbar optic neuritis (HP:0100654)2.28102426
50Abnormality of T cells (HP:0002843)2.26436955
51Autoimmune thrombocytopenia (HP:0001973)2.25908995
52Pancreatic cysts (HP:0001737)2.21015358
53Autoimmune hemolytic anemia (HP:0001890)2.20842832
54Abnormality of glycine metabolism (HP:0010895)2.20532167
55Abnormality of serine family amino acid metabolism (HP:0010894)2.20532167
56Lipid accumulation in hepatocytes (HP:0006561)2.17632039
57Reduced antithrombin III activity (HP:0001976)2.16301075
58Thyroiditis (HP:0100646)2.11940875
59Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.11739728
60Decreased activity of mitochondrial respiratory chain (HP:0008972)2.11739728
61Atrophy/Degeneration involving motor neurons (HP:0007373)2.10351721
62Cortical visual impairment (HP:0100704)2.09997494
63Progressive macrocephaly (HP:0004481)2.09033133
64Amyotrophic lateral sclerosis (HP:0007354)2.08962922
65Mesangial abnormality (HP:0001966)2.06789242
66Cerebral edema (HP:0002181)2.05412252
67Exercise intolerance (HP:0003546)2.04072610
68Abnormality of transition element cation homeostasis (HP:0011030)2.03959509
69Abnormality of aspartate family amino acid metabolism (HP:0010899)2.02551213
70Attenuation of retinal blood vessels (HP:0007843)2.00835373
71Aplastic anemia (HP:0001915)2.00330711
72Molar tooth sign on MRI (HP:0002419)1.98799131
73Abnormality of midbrain morphology (HP:0002418)1.98799131
74Concave nail (HP:0001598)1.98299838
75Large for gestational age (HP:0001520)1.98202439
76Lactic acidosis (HP:0003128)1.98140500
77Abolished electroretinogram (ERG) (HP:0000550)1.94187854
78Abnormal rod and cone electroretinograms (HP:0008323)1.89352522
79Spontaneous abortion (HP:0005268)1.89274174
80Increased hepatocellular lipid droplets (HP:0006565)1.89073638
81IgA deficiency (HP:0002720)1.88082765
82Abnormal protein N-linked glycosylation (HP:0012347)1.87929101
83Abnormal protein glycosylation (HP:0012346)1.87929101
84Abnormal glycosylation (HP:0012345)1.87929101
85Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.87929101
86Aplasia/Hypoplasia involving the musculature (HP:0001460)1.86313082
87Acute hepatic failure (HP:0006554)1.85623676
88Skin rash (HP:0000988)1.85363164
89Abnormality of placental membranes (HP:0011409)1.85088718
90Amniotic constriction ring (HP:0009775)1.85088718
91Ependymoma (HP:0002888)1.84542946
92Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.83934261
93Bile duct proliferation (HP:0001408)1.83017251
94Abnormal biliary tract physiology (HP:0012439)1.83017251
95Optic disc pallor (HP:0000543)1.78254643
96Pancytopenia (HP:0001876)1.78055249
97Pulmonary infiltrates (HP:0002113)1.77277322
98Widely spaced teeth (HP:0000687)1.73943012
99Thrombocytosis (HP:0001894)1.73793225
100Aplasia of the musculature (HP:0100854)1.73768963

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM284.00839150
2EIF2AK33.55642788
3TXK3.30950348
4FLT33.14253982
5SIK33.04335974
6BRSK23.03783686
7CAMKK23.02875398
8PIM22.90445085
9TSSK62.54093376
10STK242.37924002
11NEK12.32203027
12STK38L2.15199041
13EIF2AK12.13572388
14PKN22.00508145
15BCR1.85646379
16NUAK11.75472215
17TEC1.74633304
18BCKDK1.54751894
19PINK11.52260823
20MAP4K11.49615929
21MST41.47870677
22VRK21.47223680
23ITK1.34437518
24MAP2K61.34098632
25TAOK31.32703047
26PAK31.29743482
27IRAK41.27519257
28EIF2AK21.21769117
29ADRBK21.20897795
30KDR1.15697096
31GRK11.14562816
32BMPR1B1.12400749
33BTK1.12331871
34TBK11.11483153
35PLK31.09924307
36PIK3CG1.07601501
37PRKCQ1.05629743
38FRK1.01729996
39MAP3K50.99129720
40MAP2K70.98223251
41DYRK1B0.94060651
42BRSK10.93887643
43KIT0.91327005
44ZAK0.86149007
45CAMKK10.85260654
46WNK30.85166027
47SRPK10.85137897
48MAP4K20.84729593
49SYK0.82425818
50VRK10.81480776
51NME10.80476947
52TLK10.73716734
53STK30.73047784
54MAP3K140.71545443
55IRAK20.70514346
56PAK60.67051749
57CSF1R0.66423000
58KSR10.66127549
59NME20.65260759
60AKT30.61941075
61IRAK10.60118503
62STK390.59200859
63PKN10.56750434
64OXSR10.56090760
65LATS10.56005192
66DYRK20.55922358
67ADRBK10.54059025
68MAPK130.53738971
69DAPK10.52399683
70PASK0.52204919
71IKBKE0.51917394
72INSRR0.51764081
73PIM10.48734596
74FGFR10.48344913
75GRK50.48201785
76HCK0.47186032
77CCNB10.47092395
78MAPKAPK30.46795782
79LYN0.46503105
80ERBB30.46483577
81PRKAA10.45906353
82CSNK1A10.43881205
83TESK20.43833157
84CSNK1G10.43248845
85ABL10.43027223
86IGF1R0.42751992
87MAP3K40.42325606
88CAMK2D0.41369982
89BMPR20.40506805
90ACVR1B0.40491525
91TNK20.38993735
92CSNK1G30.38924127
93CAMK2A0.38032933
94MINK10.36129228
95ABL20.36112671
96LCK0.35453567
97CSNK1A1L0.33833469
98PRKCE0.33176047
99RAF10.31805359
100MET0.30893149

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.43708448
2Protein export_Homo sapiens_hsa030604.62652273
3Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.02624098
4Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.84818020
5Primary immunodeficiency_Homo sapiens_hsa053402.79214054
6Oxidative phosphorylation_Homo sapiens_hsa001902.24026541
7Regulation of autophagy_Homo sapiens_hsa041402.17532464
8Phototransduction_Homo sapiens_hsa047442.10828208
9Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.05384850
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.03533275
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.00735810
12Basal transcription factors_Homo sapiens_hsa030221.98271579
13Propanoate metabolism_Homo sapiens_hsa006401.97959931
14Parkinsons disease_Homo sapiens_hsa050121.95854849
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.92033812
16RNA polymerase_Homo sapiens_hsa030201.82012379
17Butanoate metabolism_Homo sapiens_hsa006501.75107359
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.71051309
19Caffeine metabolism_Homo sapiens_hsa002321.70496964
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.69410040
21RNA degradation_Homo sapiens_hsa030181.58891588
22Intestinal immune network for IgA production_Homo sapiens_hsa046721.57737368
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.55284549
24Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.50118869
25Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.49729825
26Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.45704411
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.44677072
28Allograft rejection_Homo sapiens_hsa053301.33554415
29One carbon pool by folate_Homo sapiens_hsa006701.32883918
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.30358503
31Circadian rhythm_Homo sapiens_hsa047101.29873836
32Huntingtons disease_Homo sapiens_hsa050161.27174133
33Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.26941917
34Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.17360479
35Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.16989806
36Type I diabetes mellitus_Homo sapiens_hsa049401.14642131
37Peroxisome_Homo sapiens_hsa041461.14325912
38Antigen processing and presentation_Homo sapiens_hsa046121.06003418
39Graft-versus-host disease_Homo sapiens_hsa053321.03999354
40Steroid biosynthesis_Homo sapiens_hsa001001.01552323
41Alzheimers disease_Homo sapiens_hsa050100.97354037
42Carbon metabolism_Homo sapiens_hsa012000.96224390
43Primary bile acid biosynthesis_Homo sapiens_hsa001200.93456655
44Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.93180327
45RNA transport_Homo sapiens_hsa030130.92614668
46Purine metabolism_Homo sapiens_hsa002300.91831248
47Pyrimidine metabolism_Homo sapiens_hsa002400.91347340
48Fatty acid elongation_Homo sapiens_hsa000620.90222530
49Jak-STAT signaling pathway_Homo sapiens_hsa046300.88035731
50Biosynthesis of amino acids_Homo sapiens_hsa012300.87099375
51SNARE interactions in vesicular transport_Homo sapiens_hsa041300.86051505
52Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.82930000
53Vitamin B6 metabolism_Homo sapiens_hsa007500.82732706
54Olfactory transduction_Homo sapiens_hsa047400.82710641
55Autoimmune thyroid disease_Homo sapiens_hsa053200.81313479
56Cysteine and methionine metabolism_Homo sapiens_hsa002700.80589538
57Collecting duct acid secretion_Homo sapiens_hsa049660.78167796
58Homologous recombination_Homo sapiens_hsa034400.74609444
59Fatty acid degradation_Homo sapiens_hsa000710.73076150
60T cell receptor signaling pathway_Homo sapiens_hsa046600.72693968
61Metabolic pathways_Homo sapiens_hsa011000.71527328
62Tryptophan metabolism_Homo sapiens_hsa003800.68767364
63Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.68458123
64Fatty acid metabolism_Homo sapiens_hsa012120.68143097
65Pyruvate metabolism_Homo sapiens_hsa006200.67849086
66Measles_Homo sapiens_hsa051620.67773760
67Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.66667161
68Hematopoietic cell lineage_Homo sapiens_hsa046400.60992925
69RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.60072556
70beta-Alanine metabolism_Homo sapiens_hsa004100.58450449
71Rheumatoid arthritis_Homo sapiens_hsa053230.58152681
72Asthma_Homo sapiens_hsa053100.57600450
73Epstein-Barr virus infection_Homo sapiens_hsa051690.56506375
74Cardiac muscle contraction_Homo sapiens_hsa042600.55139295
75Nitrogen metabolism_Homo sapiens_hsa009100.53890751
76Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.53726267
77Fructose and mannose metabolism_Homo sapiens_hsa000510.51551418
78Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.51224368
79Spliceosome_Homo sapiens_hsa030400.51187788
80Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.50726097
81Glycerolipid metabolism_Homo sapiens_hsa005610.44755384
82NF-kappa B signaling pathway_Homo sapiens_hsa040640.43564372
83Linoleic acid metabolism_Homo sapiens_hsa005910.41454941
84Sulfur metabolism_Homo sapiens_hsa009200.41330573
85Ether lipid metabolism_Homo sapiens_hsa005650.38728166
86Non-homologous end-joining_Homo sapiens_hsa034500.37270849
87Cyanoamino acid metabolism_Homo sapiens_hsa004600.35693176
88Nucleotide excision repair_Homo sapiens_hsa034200.33916499
89Nicotine addiction_Homo sapiens_hsa050330.33908804
90Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.33730638
91Base excision repair_Homo sapiens_hsa034100.33097136
92Steroid hormone biosynthesis_Homo sapiens_hsa001400.31455196
93Malaria_Homo sapiens_hsa051440.28196456
94N-Glycan biosynthesis_Homo sapiens_hsa005100.26655726
95Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.26499626
96Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.25264429
97mRNA surveillance pathway_Homo sapiens_hsa030150.23908307
98Fanconi anemia pathway_Homo sapiens_hsa034600.23483804
99Retinol metabolism_Homo sapiens_hsa008300.22439396
100Chemical carcinogenesis_Homo sapiens_hsa052040.22290822

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »