DAP3P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1signal peptide processing (GO:0006465)8.83591786
2otic vesicle formation (GO:0030916)8.82000231
3positive regulation of uterine smooth muscle contraction (GO:0070474)7.94845567
4positive regulation of respiratory burst (GO:0060267)7.67731873
5negative regulation of norepinephrine secretion (GO:0010700)6.44113190
6regulation of uterine smooth muscle contraction (GO:0070472)6.07719444
7phospholipid scrambling (GO:0017121)5.53957975
8ribosomal small subunit assembly (GO:0000028)5.30787420
9maturation of SSU-rRNA (GO:0030490)5.26663110
10viral transcription (GO:0019083)5.11580427
11translational termination (GO:0006415)5.10025366
12negative regulation of transcription regulatory region DNA binding (GO:2000678)4.91528439
13nodal signaling pathway (GO:0038092)4.74474458
14ribosomal large subunit biogenesis (GO:0042273)4.42084806
15protein-cofactor linkage (GO:0018065)4.39093927
16regulation of respiratory burst (GO:0060263)4.37199103
17male meiosis (GO:0007140)4.33990087
18translational elongation (GO:0006414)4.26284286
19SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.25119708
20protein targeting to ER (GO:0045047)4.24446903
21cotranslational protein targeting to membrane (GO:0006613)4.22088145
22positive regulation of prostaglandin secretion (GO:0032308)4.21848969
23negative regulation of catecholamine secretion (GO:0033604)4.18428033
24forebrain morphogenesis (GO:0048853)4.11747764
25protein localization to endoplasmic reticulum (GO:0070972)4.09888700
26establishment of protein localization to endoplasmic reticulum (GO:0072599)4.05085951
27photoreceptor cell maintenance (GO:0045494)4.02327046
28positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)3.96964156
29viral life cycle (GO:0019058)3.79870025
30cellular protein complex disassembly (GO:0043624)3.76382681
31mitochondrial respiratory chain complex assembly (GO:0033108)3.71602565
32single strand break repair (GO:0000012)3.62350465
33nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.60319985
34protein complex biogenesis (GO:0070271)3.46356138
35translational initiation (GO:0006413)3.43391033
36tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.42671036
37RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.42671036
38regulation of prostaglandin secretion (GO:0032306)3.39228675
39neural tube formation (GO:0001841)3.36152788
40negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.36147152
41behavioral response to nicotine (GO:0035095)3.35973648
42regulation of norepinephrine secretion (GO:0014061)3.34819078
43positive regulation of cAMP-mediated signaling (GO:0043950)3.32482077
44auditory receptor cell stereocilium organization (GO:0060088)3.28913822
45positive regulation of vasculogenesis (GO:2001214)3.21036276
46regulation of mesenchymal cell apoptotic process (GO:2001053)3.20768154
47activation of protein kinase B activity (GO:0032148)3.20064448
48adrenergic receptor signaling pathway (GO:0071875)3.19144086
49protein complex disassembly (GO:0043241)3.18891403
50negative regulation of thymocyte apoptotic process (GO:0070244)3.15285432
51cytochrome complex assembly (GO:0017004)3.11097269
52macromolecular complex disassembly (GO:0032984)3.08947566
53inner mitochondrial membrane organization (GO:0007007)3.06554813
54phasic smooth muscle contraction (GO:0014821)3.05179844
55detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.03056119
56protein K6-linked ubiquitination (GO:0085020)3.00013802
57response to pheromone (GO:0019236)2.95637982
58regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.92297514
59regulation of thymocyte apoptotic process (GO:0070243)2.91874424
60epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.91352280
61regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.90430773
62regulation of mitotic spindle checkpoint (GO:1903504)2.90430773
63cell wall macromolecule catabolic process (GO:0016998)2.89059419
64respiratory chain complex IV assembly (GO:0008535)2.85444575
65mitochondrial respiratory chain complex I assembly (GO:0032981)2.85053073
66NADH dehydrogenase complex assembly (GO:0010257)2.85053073
67mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.85053073
68protein targeting to membrane (GO:0006612)2.84974641
69protein import into peroxisome matrix (GO:0016558)2.84949920
70positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)2.84636202
71ribosomal small subunit biogenesis (GO:0042274)2.83555040
72regulation of mitochondrial translation (GO:0070129)2.82221095
73termination of RNA polymerase III transcription (GO:0006386)2.80971654
74transcription elongation from RNA polymerase III promoter (GO:0006385)2.80971654
75positive regulation of ERBB signaling pathway (GO:1901186)2.78337734
76autophagic vacuole fusion (GO:0000046)2.77859493
77oxidative demethylation (GO:0070989)2.77435075
78platelet dense granule organization (GO:0060155)2.76458951
79tryptophan catabolic process (GO:0006569)2.75590961
80indole-containing compound catabolic process (GO:0042436)2.75590961
81indolalkylamine catabolic process (GO:0046218)2.75590961
82serotonin receptor signaling pathway (GO:0007210)2.74520262
83coenzyme catabolic process (GO:0009109)2.74028177
84regulation of transcription regulatory region DNA binding (GO:2000677)2.72291182
85branched-chain amino acid catabolic process (GO:0009083)2.70138277
86rRNA methylation (GO:0031167)2.69186336
87relaxation of smooth muscle (GO:0044557)2.64020168
88regulation of non-canonical Wnt signaling pathway (GO:2000050)2.61635840
89tRNA processing (GO:0008033)2.60704888
90regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.60115609
91regulation of hexokinase activity (GO:1903299)2.60011510
92regulation of glucokinase activity (GO:0033131)2.60011510
93negative regulation of cytosolic calcium ion concentration (GO:0051481)2.58882162
94nuclear-transcribed mRNA catabolic process (GO:0000956)2.53752443
95Peyers patch development (GO:0048541)2.51926727
96mucosal-associated lymphoid tissue development (GO:0048537)2.51926727
97DNA demethylation (GO:0080111)2.51869551
98DNA dealkylation (GO:0035510)2.51693081
99positive regulation of glycolytic process (GO:0045821)2.51313524
100cardiac right ventricle morphogenesis (GO:0003215)2.50902591

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EST1_17652178_ChIP-ChIP_JURKAT_Human3.99151964
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.96140033
3ZNF274_21170338_ChIP-Seq_K562_Hela3.59820952
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.59337569
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.47820418
6FLI1_27457419_Chip-Seq_LIVER_Mouse3.09275676
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.83673262
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.63938027
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.58982824
10TAF15_26573619_Chip-Seq_HEK293_Human2.23369003
11VDR_23849224_ChIP-Seq_CD4+_Human2.17625783
12PCGF2_27294783_Chip-Seq_ESCs_Mouse2.16293080
13RBPJ_22232070_ChIP-Seq_NCS_Mouse2.13538299
14FOXA1_27270436_Chip-Seq_PROSTATE_Human2.07436802
15FOXA1_25329375_ChIP-Seq_VCAP_Human2.07436802
16ELK1_19687146_ChIP-ChIP_HELA_Human2.05103229
17MYC_18940864_ChIP-ChIP_HL60_Human2.04607766
18NOTCH1_21737748_ChIP-Seq_TLL_Human2.02031441
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.01971779
20ETS1_20019798_ChIP-Seq_JURKAT_Human1.97479346
21FOXP3_21729870_ChIP-Seq_TREG_Human1.94336344
22BCAT_22108803_ChIP-Seq_LS180_Human1.91889050
23JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.87819967
24FUS_26573619_Chip-Seq_HEK293_Human1.79914551
25TP53_22573176_ChIP-Seq_HFKS_Human1.72087080
26SRF_21415370_ChIP-Seq_HL-1_Mouse1.70055216
27ELF1_17652178_ChIP-ChIP_JURKAT_Human1.65992930
28AR_20517297_ChIP-Seq_VCAP_Human1.61631596
29IRF8_22096565_ChIP-ChIP_GC-B_Human1.60552071
30E2F7_22180533_ChIP-Seq_HELA_Human1.59157551
31E2F4_17652178_ChIP-ChIP_JURKAT_Human1.57849919
32P300_19829295_ChIP-Seq_ESCs_Human1.51259931
33TP63_19390658_ChIP-ChIP_HaCaT_Human1.49102619
34CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.46500515
35HOXB4_20404135_ChIP-ChIP_EML_Mouse1.41758482
36EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.38000887
37FOXA1_21572438_ChIP-Seq_LNCaP_Human1.34777036
38EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.34775783
39EZH2_27294783_Chip-Seq_NPCs_Mouse1.32099200
40TTF2_22483619_ChIP-Seq_HELA_Human1.30401052
41IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.29351963
42GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.28006919
43STAT1_20625510_ChIP-Seq_HELA_Human1.27479638
44EWS_26573619_Chip-Seq_HEK293_Human1.26307056
45MYC_18555785_ChIP-Seq_MESCs_Mouse1.24176831
46POU3F2_20337985_ChIP-ChIP_501MEL_Human1.23964275
47RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.23669495
48DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.23231934
49HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.21316045
50HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.21130684
51HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.20216624
52NELFA_20434984_ChIP-Seq_ESCs_Mouse1.19661565
53CTBP1_25329375_ChIP-Seq_LNCAP_Human1.19297097
54IGF1R_20145208_ChIP-Seq_DFB_Human1.18838734
55FOXH1_21741376_ChIP-Seq_EPCs_Human1.18416812
56IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.18391395
57MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.18147723
58GATA3_26560356_Chip-Seq_TH2_Human1.16024579
59UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.14379225
60NCOR_22424771_ChIP-Seq_293T_Human1.14259223
61FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.12546777
62GATA3_21878914_ChIP-Seq_MCF-7_Human1.11196442
63ELK1_22589737_ChIP-Seq_MCF10A_Human1.10919992
64LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.09698760
65MYC_19079543_ChIP-ChIP_MESCs_Mouse1.08282019
66BMI1_23680149_ChIP-Seq_NPCS_Mouse1.07506010
67TCF4_22108803_ChIP-Seq_LS180_Human1.06914624
68ERG_20517297_ChIP-Seq_VCAP_Human1.06086489
69PADI4_21655091_ChIP-ChIP_MCF-7_Human1.05816618
70POU5F1_16153702_ChIP-ChIP_HESCs_Human1.03255073
71CREB1_15753290_ChIP-ChIP_HEK293T_Human1.01357691
72SALL4_22934838_ChIP-ChIP_CD34+_Human1.01356933
73PCGF2_27294783_Chip-Seq_NPCs_Mouse1.01071830
74SUZ12_18555785_Chip-Seq_ESCs_Mouse0.98090342
75NANOG_20526341_ChIP-Seq_ESCs_Human0.96017850
76NR3C1_21868756_ChIP-Seq_MCF10A_Human0.94909959
77SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.94605806
78CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.94518549
79NFE2_27457419_Chip-Seq_LIVER_Mouse0.94365319
80E2F1_18555785_Chip-Seq_ESCs_Mouse0.93162413
81SMAD1_18555785_Chip-Seq_ESCs_Mouse0.92417251
82CBP_21632823_ChIP-Seq_H3396_Human0.92051306
83CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.92040502
84CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.91837431
85MYC_19829295_ChIP-Seq_ESCs_Human0.91668658
86CRX_20693478_ChIP-Seq_RETINA_Mouse0.91527793
87ER_23166858_ChIP-Seq_MCF-7_Human0.90898337
88ETV2_25802403_ChIP-Seq_MESCs_Mouse0.90269084
89ZFP57_27257070_Chip-Seq_ESCs_Mouse0.89726959
90AR_21572438_ChIP-Seq_LNCaP_Human0.89178935
91EGR1_23403033_ChIP-Seq_LIVER_Mouse0.89155259
92IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.88834511
93CBP_20019798_ChIP-Seq_JUKART_Human0.88834511
94CDX2_22108803_ChIP-Seq_LS180_Human0.88397835
95STAT3_18555785_Chip-Seq_ESCs_Mouse0.87330924
96BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.86987611
97AUTS2_25519132_ChIP-Seq_293T-REX_Human0.86539465
98P300_18555785_Chip-Seq_ESCs_Mouse0.85331256
99ZFX_18555785_Chip-Seq_ESCs_Mouse0.84628596
100OCT4_18555785_Chip-Seq_ESCs_Mouse0.84349197

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode6.35907403
2MP0009379_abnormal_foot_pigmentation5.96480972
3MP0002277_abnormal_respiratory_mucosa3.97262724
4MP0008877_abnormal_DNA_methylation3.67573565
5MP0004885_abnormal_endolymph3.66326837
6MP0005084_abnormal_gallbladder_morpholo3.30550231
7MP0005377_hearing/vestibular/ear_phenot3.11541712
8MP0003878_abnormal_ear_physiology3.11541712
9MP0009780_abnormal_chondrocyte_physiolo2.80621527
10MP0003938_abnormal_ear_development2.58162433
11MP0003136_yellow_coat_color2.35984821
12MP0006072_abnormal_retinal_apoptosis2.02975946
13MP0000383_abnormal_hair_follicle2.00163438
14MP0003252_abnormal_bile_duct1.98833106
15MP0002254_reproductive_system_inflammat1.97545636
16MP0005075_abnormal_melanosome_morpholog1.90395121
17MP0005551_abnormal_eye_electrophysiolog1.88847268
18MP0000372_irregular_coat_pigmentation1.86720586
19MP0005174_abnormal_tail_pigmentation1.82894542
20MP0001756_abnormal_urination1.82268021
21MP0010678_abnormal_skin_adnexa1.75275870
22MP0008058_abnormal_DNA_repair1.70576436
23MP0002938_white_spotting1.66538776
24MP0005645_abnormal_hypothalamus_physiol1.57524666
25MP0001984_abnormal_olfaction1.55352986
26MP0001873_stomach_inflammation1.54064177
27MP0003693_abnormal_embryo_hatching1.53088279
28MP0001324_abnormal_eye_pigmentation1.48299057
29MP0001485_abnormal_pinna_reflex1.44185055
30MP0000647_abnormal_sebaceous_gland1.44074689
31MP0002095_abnormal_skin_pigmentation1.43229270
32MP0001346_abnormal_lacrimal_gland1.42391615
33MP0002233_abnormal_nose_morphology1.36492926
34MP0005410_abnormal_fertilization1.35173738
35MP0004133_heterotaxia1.33468607
36MP0001529_abnormal_vocalization1.32351740
37MP0004742_abnormal_vestibular_system1.31421713
38MP0000427_abnormal_hair_cycle1.30287577
39MP0003646_muscle_fatigue1.30088807
40MP0005365_abnormal_bile_salt1.28202101
41MP0003787_abnormal_imprinting1.26676876
42MP0000566_synostosis1.25905373
43MP0001299_abnormal_eye_distance/1.23817991
44MP0008872_abnormal_physiological_respon1.22984729
45MP0005595_abnormal_vascular_smooth1.21542122
46MP0000631_abnormal_neuroendocrine_gland1.17344851
47MP0008875_abnormal_xenobiotic_pharmacok1.16780937
48MP0008789_abnormal_olfactory_epithelium1.16572124
49MP0005187_abnormal_penis_morphology1.14835702
50MP0002638_abnormal_pupillary_reflex1.13265974
51MP0002132_abnormal_respiratory_system1.12668548
52MP0000371_diluted_coat_color1.12257277
53MP0002282_abnormal_trachea_morphology1.10352406
54MP0008007_abnormal_cellular_replicative1.09339999
55MP0002098_abnormal_vibrissa_morphology1.08578918
56MP0003195_calcinosis1.07278120
57MP0001849_ear_inflammation1.05322964
58MP0000462_abnormal_digestive_system1.03544947
59MP0000015_abnormal_ear_pigmentation0.99710427
60MP0002163_abnormal_gland_morphology0.95824308
61MP0003638_abnormal_response/metabolism_0.94068317
62MP0004381_abnormal_hair_follicle0.91970582
63MP0003011_delayed_dark_adaptation0.91766433
64MP0002102_abnormal_ear_morphology0.90445464
65MP0002396_abnormal_hematopoietic_system0.85487570
66MP0002295_abnormal_pulmonary_circulatio0.85220360
67MP0008775_abnormal_heart_ventricle0.83529816
68MP0002928_abnormal_bile_duct0.83108607
69MP0002876_abnormal_thyroid_physiology0.82555679
70MP0003718_maternal_effect0.82336789
71MP0005319_abnormal_enzyme/_coenzyme0.81564728
72MP0002138_abnormal_hepatobiliary_system0.81088480
73MP0005253_abnormal_eye_physiology0.80504222
74MP0001293_anophthalmia0.79836430
75MP0004043_abnormal_pH_regulation0.73472535
76MP0003866_abnormal_defecation0.72801609
77MP0009785_altered_susceptibility_to0.72148713
78MP0003724_increased_susceptibility_to0.69740146
79MP0004134_abnormal_chest_morphology0.69730544
80MP0006276_abnormal_autonomic_nervous0.69097201
81MP0010030_abnormal_orbit_morphology0.68222843
82MP0005379_endocrine/exocrine_gland_phen0.66324720
83MP0004019_abnormal_vitamin_homeostasis0.66176872
84MP0006035_abnormal_mitochondrial_morpho0.66058268
85MP0004147_increased_porphyrin_level0.64966725
86MP0001764_abnormal_homeostasis0.64934897
87MP0001963_abnormal_hearing_physiology0.63859106
88MP0005671_abnormal_response_to0.63664189
89MP0001881_abnormal_mammary_gland0.63231075
90MP0000627_abnormal_mammary_gland0.61402074
91MP0001765_abnormal_ion_homeostasis0.61328348
92MP0003936_abnormal_reproductive_system0.59013599
93MP0005195_abnormal_posterior_eye0.57662797
94MP0009643_abnormal_urine_homeostasis0.56608105
95MP0000026_abnormal_inner_ear0.54821496
96MP0002736_abnormal_nociception_after0.54011937
97MP0001986_abnormal_taste_sensitivity0.52260949
98MP0005448_abnormal_energy_balance0.52174084
99MP0002136_abnormal_kidney_physiology0.51856000
100MP0000230_abnormal_systemic_arterial0.49990439

Predicted human phenotypes

RankGene SetZ-score
1Septo-optic dysplasia (HP:0100842)5.61991159
2Pancreatic islet-cell hyperplasia (HP:0004510)4.69227476
3Abnormality of the renal medulla (HP:0100957)3.86604311
4Abnormality of the renal cortex (HP:0011035)3.81334220
5Volvulus (HP:0002580)3.79066038
6Hypoglycemic seizures (HP:0002173)3.74041994
7Tubular atrophy (HP:0000092)3.73160787
8Nephronophthisis (HP:0000090)3.62396386
9Partial duplication of thumb phalanx (HP:0009944)3.32484737
10Hyperinsulinemic hypoglycemia (HP:0000825)3.27687091
11Congenital, generalized hypertrichosis (HP:0004540)3.20990690
12Maternal diabetes (HP:0009800)3.15231033
13Amaurosis fugax (HP:0100576)3.13536423
14Pancreatic cysts (HP:0001737)3.10032295
15Birth length less than 3rd percentile (HP:0003561)3.01188372
16Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.96190958
17Facial shape deformation (HP:0011334)2.94718905
18Potter facies (HP:0002009)2.94718905
19Reticulocytopenia (HP:0001896)2.93438400
20Morphological abnormality of the inner ear (HP:0011390)2.88064745
21Absent septum pellucidum (HP:0001331)2.84328401
22Optic nerve hypoplasia (HP:0000609)2.82961298
23Attenuation of retinal blood vessels (HP:0007843)2.82080272
24Hypoglycemic coma (HP:0001325)2.80192375
25Abnormality of endocrine pancreas physiology (HP:0012093)2.72371696
26Abnormality of the pancreatic islet cells (HP:0006476)2.72371696
27Symptomatic seizures (HP:0011145)2.71585930
28Partial duplication of the phalanx of hand (HP:0009999)2.71287774
29Intestinal atresia (HP:0011100)2.67748850
30Triphalangeal thumb (HP:0001199)2.61492753
31Colon cancer (HP:0003003)2.60461412
32Gastrointestinal atresia (HP:0002589)2.58234411
33Urethral obstruction (HP:0000796)2.56507752
34Hemiparesis (HP:0001269)2.55761190
35Abnormal drinking behavior (HP:0030082)2.54473570
36Polydipsia (HP:0001959)2.54473570
37Molar tooth sign on MRI (HP:0002419)2.50427041
38Abnormality of midbrain morphology (HP:0002418)2.50427041
39Abolished electroretinogram (ERG) (HP:0000550)2.50028561
40Pancreatic fibrosis (HP:0100732)2.45971383
41Renal cortical cysts (HP:0000803)2.43553280
42Medial flaring of the eyebrow (HP:0010747)2.40552853
43Stomach cancer (HP:0012126)2.39940829
44Macrocytic anemia (HP:0001972)2.39362950
45Inability to walk (HP:0002540)2.34535948
46Increased hepatocellular lipid droplets (HP:0006565)2.33915577
47Respiratory difficulties (HP:0002880)2.30904811
48Lipid accumulation in hepatocytes (HP:0006561)2.29342206
49Conical tooth (HP:0000698)2.28209807
50Long foot (HP:0001833)2.27328903
51Hyperglycemia (HP:0003074)2.25148890
52Esophageal atresia (HP:0002032)2.21239860
53Enlarged kidneys (HP:0000105)2.20430430
54Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.19056157
55Abnormality of the septum pellucidum (HP:0007375)2.17265484
56Abnormality of the ileum (HP:0001549)2.17028040
57Abnormality of macular pigmentation (HP:0008002)2.16169522
58Stenosis of the external auditory canal (HP:0000402)2.14154728
59Congenital stationary night blindness (HP:0007642)2.13603806
60Bile duct proliferation (HP:0001408)2.13410669
61Abnormal biliary tract physiology (HP:0012439)2.13410669
62Increased neuronal autofluorescent lipopigment (HP:0002074)2.06912359
63Tubulointerstitial fibrosis (HP:0005576)2.04918691
64Tubulointerstitial abnormality (HP:0001969)2.01523194
65Hypomagnesemia (HP:0002917)2.00964932
66Abnormality of the labia minora (HP:0012880)1.99270849
67Renal Fanconi syndrome (HP:0001994)1.97640586
68Polyuria (HP:0000103)1.97519949
69Breast aplasia (HP:0100783)1.97302884
70Progressive inability to walk (HP:0002505)1.96858466
71Decreased central vision (HP:0007663)1.93639550
72Abnormality of the parietal bone (HP:0002696)1.93542548
73Congenital hepatic fibrosis (HP:0002612)1.93253373
74Growth hormone deficiency (HP:0000824)1.90162141
75Vaginal atresia (HP:0000148)1.88906783
76Increased CSF lactate (HP:0002490)1.88438054
77Cystic liver disease (HP:0006706)1.87522409
78Enlarged penis (HP:0000040)1.87053419
79Congenital sensorineural hearing impairment (HP:0008527)1.86421019
80Clitoromegaly (HP:0000057)1.85738883
81Congenital primary aphakia (HP:0007707)1.84992425
82Cerebellar dysplasia (HP:0007033)1.84516373
83Median cleft lip (HP:0000161)1.82898070
84Tubulointerstitial nephritis (HP:0001970)1.82805525
85Aplasia/Hypoplasia of the uvula (HP:0010293)1.78538280
86Pallor (HP:0000980)1.78071571
87Genital tract atresia (HP:0001827)1.77823365
88Breech presentation (HP:0001623)1.77415882
89Hypokalemic alkalosis (HP:0001949)1.73843773
90Abnormal number of erythroid precursors (HP:0012131)1.73343966
91Gait imbalance (HP:0002141)1.73121229
92Albinism (HP:0001022)1.72111035
93Abnormal delayed hypersensitivity skin test (HP:0002963)1.71804051
94Abnormality of urine glucose concentration (HP:0011016)1.69265346
95Glycosuria (HP:0003076)1.69265346
96Renal dysplasia (HP:0000110)1.69047545
97Meckel diverticulum (HP:0002245)1.68709855
98Retinal dysplasia (HP:0007973)1.64230199
99Aplasia/Hypoplasia of the breasts (HP:0010311)1.63621733
100Neonatal short-limb short stature (HP:0008921)1.62935043

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR8.52193021
2BCKDK2.72730736
3BMPR1B2.62148224
4MAP3K142.62022088
5STK392.50315644
6WNK42.50229189
7FRK2.49508312
8STK38L2.26957671
9MST42.14787988
10PASK2.07229046
11TEC1.91130701
12BUB11.90511218
13PBK1.70833924
14RPS6KA41.57260492
15ADRBK21.55741302
16TXK1.48063029
17DYRK1B1.39223307
18STK241.33758706
19FGFR21.33538445
20BCR1.31032852
21PRKD31.28329051
22MAP3K121.19058752
23FES1.18930021
24CSNK1G31.18591878
25PRKCQ1.17321742
26BTK1.16125733
27CDK191.13661923
28TAOK31.12617747
29KDR1.10833596
30MAP2K61.10095935
31OXSR11.09554555
32GRK61.08245150
33CDC71.06986521
34ITK1.06277245
35TGFBR11.05374866
36WNK31.04732761
37VRK21.03263152
38CSNK1G11.01961888
39KIT1.00185538
40MAP4K20.97121646
41CAMKK10.89822117
42ZAK0.89121231
43TNK20.88315148
44MAP3K130.83886790
45NUAK10.83469874
46CSNK1A1L0.82107819
47FGR0.81978147
48MAP2K70.80284784
49GRK10.80017983
50STK30.79093915
51MAP3K70.78077322
52CSNK1G20.77743996
53NEK20.76453441
54IKBKB0.74510568
55PINK10.72375833
56TLK10.67516084
57SYK0.65618675
58TIE10.65614133
59BRSK20.65589886
60PRKCE0.65348153
61ADRBK10.64549578
62WNK10.64463852
63FGFR10.64246713
64ZAP700.63604043
65TYRO30.59001644
66MAPK130.57102898
67PTK2B0.56155806
68FLT30.56111269
69PLK10.53720419
70BMX0.52839518
71PLK30.52829428
72IGF1R0.52317650
73PIK3CA0.50610510
74CDK40.50107082
75TAF10.49898022
76LRRK20.48914029
77EGFR0.48258887
78CASK0.48093797
79VRK10.45452404
80CSNK1D0.45342280
81PRKD20.43462487
82CAMK10.42713553
83RPS6KA50.41986155
84PDK20.41827027
85MAP2K40.41505891
86DAPK30.41228967
87LYN0.40123271
88WEE10.39934450
89PKN10.39340331
90ATR0.38945642
91CSNK1A10.38833294
92RPS6KB20.36391386
93CSNK2A20.36137586
94TSSK60.35640340
95CDK30.35406250
96NLK0.31728261
97CAMK2G0.31456650
98PRKCH0.31362130
99CSNK2A10.30992979
100ATM0.30936683

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.35076415
2One carbon pool by folate_Homo sapiens_hsa006703.59661435
3RNA polymerase_Homo sapiens_hsa030203.45193493
4Proteasome_Homo sapiens_hsa030503.28987963
5Homologous recombination_Homo sapiens_hsa034402.53536727
6Oxidative phosphorylation_Homo sapiens_hsa001902.19114818
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.00379918
8Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.93355622
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.91035234
10Tryptophan metabolism_Homo sapiens_hsa003801.90880310
11Phototransduction_Homo sapiens_hsa047441.89986147
12Propanoate metabolism_Homo sapiens_hsa006401.83905676
13Folate biosynthesis_Homo sapiens_hsa007901.82787998
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.78484469
15Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.68348763
16Retinol metabolism_Homo sapiens_hsa008301.64707886
17Fanconi anemia pathway_Homo sapiens_hsa034601.59327569
18Parkinsons disease_Homo sapiens_hsa050121.59231792
19Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.58772645
20Peroxisome_Homo sapiens_hsa041461.54832168
21Pyrimidine metabolism_Homo sapiens_hsa002401.49481658
22Protein export_Homo sapiens_hsa030601.45813663
23Maturity onset diabetes of the young_Homo sapiens_hsa049501.43402172
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.43146684
25Pentose and glucuronate interconversions_Homo sapiens_hsa000401.40556617
26Huntingtons disease_Homo sapiens_hsa050161.39578706
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.39095208
28Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.32711896
29Cyanoamino acid metabolism_Homo sapiens_hsa004601.31708049
30Purine metabolism_Homo sapiens_hsa002301.29727178
31Chemical carcinogenesis_Homo sapiens_hsa052041.26472733
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.24295445
33Steroid hormone biosynthesis_Homo sapiens_hsa001401.22313494
34Pyruvate metabolism_Homo sapiens_hsa006201.22143382
35Mismatch repair_Homo sapiens_hsa034301.21740294
36Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.21161057
37Alzheimers disease_Homo sapiens_hsa050101.19223292
38Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.11540823
39Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.10525431
40Basal transcription factors_Homo sapiens_hsa030221.10274740
41Nucleotide excision repair_Homo sapiens_hsa034201.09014882
42DNA replication_Homo sapiens_hsa030301.08763470
43RNA degradation_Homo sapiens_hsa030181.08753533
44Olfactory transduction_Homo sapiens_hsa047401.07215615
45Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.07066292
46Butanoate metabolism_Homo sapiens_hsa006501.06153827
47Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.01457040
48beta-Alanine metabolism_Homo sapiens_hsa004100.96566371
49Fatty acid elongation_Homo sapiens_hsa000620.96542958
50Selenocompound metabolism_Homo sapiens_hsa004500.96149916
51Drug metabolism - other enzymes_Homo sapiens_hsa009830.95549311
52Spliceosome_Homo sapiens_hsa030400.91662495
53Insulin secretion_Homo sapiens_hsa049110.90343530
54Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.89996002
55Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.89650785
56Glycerolipid metabolism_Homo sapiens_hsa005610.88743022
57Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.83064258
58Primary immunodeficiency_Homo sapiens_hsa053400.82986928
59Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.80151551
60Cysteine and methionine metabolism_Homo sapiens_hsa002700.79054583
61Ovarian steroidogenesis_Homo sapiens_hsa049130.78241706
62Arachidonic acid metabolism_Homo sapiens_hsa005900.77196315
63Nitrogen metabolism_Homo sapiens_hsa009100.76926845
64Taste transduction_Homo sapiens_hsa047420.76259167
65Fatty acid degradation_Homo sapiens_hsa000710.75174378
66Caffeine metabolism_Homo sapiens_hsa002320.74066457
67Base excision repair_Homo sapiens_hsa034100.73838371
68Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.72866666
69Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.70382326
70Metabolic pathways_Homo sapiens_hsa011000.68826483
71RNA transport_Homo sapiens_hsa030130.66043239
72Cardiac muscle contraction_Homo sapiens_hsa042600.64670396
73Glutathione metabolism_Homo sapiens_hsa004800.62771303
74Aldosterone synthesis and secretion_Homo sapiens_hsa049250.62393406
75Intestinal immune network for IgA production_Homo sapiens_hsa046720.61379562
76p53 signaling pathway_Homo sapiens_hsa041150.60453433
77Regulation of autophagy_Homo sapiens_hsa041400.58130122
78Circadian rhythm_Homo sapiens_hsa047100.57143125
79Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.56674744
80Thyroid hormone synthesis_Homo sapiens_hsa049180.56525242
81alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.54981096
82NOD-like receptor signaling pathway_Homo sapiens_hsa046210.54788917
83Vitamin digestion and absorption_Homo sapiens_hsa049770.54316183
84Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51905501
85NF-kappa B signaling pathway_Homo sapiens_hsa040640.47529031
86Arginine and proline metabolism_Homo sapiens_hsa003300.46716136
87Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.45355769
88TGF-beta signaling pathway_Homo sapiens_hsa043500.43892453
89Linoleic acid metabolism_Homo sapiens_hsa005910.43556579
90Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.42144588
91Salivary secretion_Homo sapiens_hsa049700.39219002
92Histidine metabolism_Homo sapiens_hsa003400.37665633
93Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.36577388
94Allograft rejection_Homo sapiens_hsa053300.31695225
95Starch and sucrose metabolism_Homo sapiens_hsa005000.30431926
96Primary bile acid biosynthesis_Homo sapiens_hsa001200.28979568
97ABC transporters_Homo sapiens_hsa020100.28714977
98Type I diabetes mellitus_Homo sapiens_hsa049400.27684085
99Cell cycle_Homo sapiens_hsa041100.27275558
100Epstein-Barr virus infection_Homo sapiens_hsa051690.26751190

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