DAPK1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Death-associated protein kinase 1 is a positive mediator of gamma-interferon induced programmed cell death. DAPK1 encodes a structurally unique 160-kD calmodulin dependent serine-threonine kinase that carries 8 ankyrin repeats and 2 putative P-loop consensus sites. It is a tumor suppressor candidate. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to peptidoglycan (GO:0032494)4.88218450
2negative regulation of erythrocyte differentiation (GO:0045647)4.26572278
3complement activation, alternative pathway (GO:0006957)4.25520950
4negative regulation of interleukin-12 production (GO:0032695)4.19404144
5alpha-linolenic acid metabolic process (GO:0036109)4.08078855
6cellular response to thyroid hormone stimulus (GO:0097067)4.00948013
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.00572153
8L-phenylalanine catabolic process (GO:0006559)4.00572153
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.96773965
10L-phenylalanine metabolic process (GO:0006558)3.83472387
11erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.83472387
12peptidyl-glutamic acid carboxylation (GO:0017187)3.76487454
13protein carboxylation (GO:0018214)3.76487454
14T-helper 1 type immune response (GO:0042088)3.72587368
15urea metabolic process (GO:0019627)3.68854944
16urea cycle (GO:0000050)3.68854944
17positive regulation of gamma-delta T cell activation (GO:0046645)3.67579015
18regulation of protein activation cascade (GO:2000257)3.63563617
19oligosaccharide catabolic process (GO:0009313)3.56510562
20aromatic amino acid family catabolic process (GO:0009074)3.53577598
21dicarboxylic acid biosynthetic process (GO:0043650)3.51839377
22neutrophil activation involved in immune response (GO:0002283)3.48279183
23regulation of complement activation (GO:0030449)3.45898728
24kynurenine metabolic process (GO:0070189)3.43966583
25positive regulation of cellular amide metabolic process (GO:0034250)3.41866506
26bile acid biosynthetic process (GO:0006699)3.39889931
27nucleobase catabolic process (GO:0046113)3.39192504
28response to muramyl dipeptide (GO:0032495)3.39178708
29negative regulation of fibrinolysis (GO:0051918)3.37749914
30immunoglobulin mediated immune response (GO:0016064)3.37638881
31macrophage activation involved in immune response (GO:0002281)3.36523010
32high-density lipoprotein particle remodeling (GO:0034375)3.36169438
33nerve growth factor signaling pathway (GO:0038180)3.36050960
34glycosphingolipid catabolic process (GO:0046479)3.33064596
35nitrogen cycle metabolic process (GO:0071941)3.28607310
36pyrimidine nucleobase catabolic process (GO:0006208)3.25733892
37plasma lipoprotein particle clearance (GO:0034381)3.21382357
38locomotory exploration behavior (GO:0035641)3.18450426
39positive regulation of lipid catabolic process (GO:0050996)3.16611625
40regulation of mononuclear cell migration (GO:0071675)3.15788732
41germinal center formation (GO:0002467)3.15760951
42glutamate metabolic process (GO:0006536)3.15520163
43regulation of fibrinolysis (GO:0051917)3.15349875
44modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.13361149
45positive regulation by organism of defense response of other organism involved in symbiotic interact3.13361149
46modulation by symbiont of host immune response (GO:0052553)3.13361149
47positive regulation by symbiont of host defense response (GO:0052509)3.13361149
48modulation by symbiont of host defense response (GO:0052031)3.13361149
49modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.13361149
50indolalkylamine catabolic process (GO:0046218)3.13256855
51tryptophan catabolic process (GO:0006569)3.13256855
52indole-containing compound catabolic process (GO:0042436)3.13256855
53positive regulation of fatty acid beta-oxidation (GO:0032000)3.11399467
54homocysteine metabolic process (GO:0050667)3.11331771
55phospholipid homeostasis (GO:0055091)3.10326795
56lysine catabolic process (GO:0006554)3.10121003
57lysine metabolic process (GO:0006553)3.10121003
58cysteine metabolic process (GO:0006534)3.09931400
59lipopolysaccharide-mediated signaling pathway (GO:0031663)3.08486624
60glyoxylate metabolic process (GO:0046487)3.08206773
61reverse cholesterol transport (GO:0043691)3.07727295
62sulfur amino acid catabolic process (GO:0000098)3.06580980
63synaptic vesicle maturation (GO:0016188)3.06237511
64cellular response to ethanol (GO:0071361)3.03256981
65regulation of short-term neuronal synaptic plasticity (GO:0048172)3.02812875
66pinocytosis (GO:0006907)3.02102050
67regulation of T-helper 1 cell differentiation (GO:0045625)3.01806684
68glycolipid catabolic process (GO:0019377)3.01174855
69regulation of macrophage chemotaxis (GO:0010758)2.99531086
70positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.99451232
71fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.97346948
72regulation of leukocyte degranulation (GO:0043300)2.97157439
73regulation of synapse structural plasticity (GO:0051823)2.96160831
74toxin transport (GO:1901998)2.95886441
75tryptophan metabolic process (GO:0006568)2.95464323
76regulation of mast cell degranulation (GO:0043304)2.95063521
77vocalization behavior (GO:0071625)2.93888950
78positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.93752414
79positive regulation of type 2 immune response (GO:0002830)2.92979639
80response to thyroid hormone (GO:0097066)2.92834525
81alanine transport (GO:0032328)2.91814567
82bile acid metabolic process (GO:0008206)2.91729904
83regulation of fatty acid beta-oxidation (GO:0031998)2.89842019
84negative regulation of sterol transport (GO:0032372)2.89169474
85negative regulation of cholesterol transport (GO:0032375)2.89169474
86neurotransmitter-gated ion channel clustering (GO:0072578)2.88170260
87positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.87608415
88plasma lipoprotein particle remodeling (GO:0034369)2.86928721
89protein-lipid complex remodeling (GO:0034368)2.86928721
90macromolecular complex remodeling (GO:0034367)2.86928721
91regulation of podosome assembly (GO:0071801)2.86800509
92positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.86780995
93layer formation in cerebral cortex (GO:0021819)2.86606521
94positive regulation of leukocyte degranulation (GO:0043302)2.85955923
95detection of molecule of bacterial origin (GO:0032490)2.82817958
96regulation of cytokine secretion involved in immune response (GO:0002739)2.82189285
97regulation of triglyceride catabolic process (GO:0010896)2.80567353
98regulation of mast cell activation involved in immune response (GO:0033006)2.80073133
99branching involved in labyrinthine layer morphogenesis (GO:0060670)2.77374759
100positive regulation of heat generation (GO:0031652)2.77165436
101regulation of cholesterol homeostasis (GO:2000188)2.76827252
102interferon-gamma-mediated signaling pathway (GO:0060333)2.76551005
103positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.76363142
104regulation of fever generation (GO:0031620)2.75764712
105regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.75230716
106definitive hemopoiesis (GO:0060216)2.74892821
107cholesterol efflux (GO:0033344)2.74775033
108positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.74079895
109serine family amino acid catabolic process (GO:0009071)2.73847401
110macroautophagy (GO:0016236)2.73179127
111phospholipid efflux (GO:0033700)2.73179027
112regulation of myeloid leukocyte mediated immunity (GO:0002886)2.72082713
113cellular modified amino acid catabolic process (GO:0042219)2.71302693
114regulation of interferon-alpha production (GO:0032647)2.70892078
115acylglycerol homeostasis (GO:0055090)2.69789902
116triglyceride homeostasis (GO:0070328)2.69789902
117cellular ketone body metabolic process (GO:0046950)2.69763449
118regulation of dendritic cell antigen processing and presentation (GO:0002604)2.69514088
119positive regulation of cholesterol efflux (GO:0010875)2.67702698
120positive regulation of B cell differentiation (GO:0045579)2.66571277
121regulation of cholesterol esterification (GO:0010872)2.65642042
122negative regulation of nitric oxide biosynthetic process (GO:0045019)2.64693229
123low-density lipoprotein particle clearance (GO:0034383)2.63128703
124positive regulation of mast cell activation (GO:0033005)2.62248229
125positive regulation of vasculogenesis (GO:2001214)2.61566542
126positive regulation of mast cell activation involved in immune response (GO:0033008)2.61206505
127positive regulation of mast cell degranulation (GO:0043306)2.61206505
128glutamate secretion (GO:0014047)2.61102526
129alpha-amino acid catabolic process (GO:1901606)2.60368926
130N-acetylneuraminate metabolic process (GO:0006054)2.60298698
131fatty acid transmembrane transport (GO:1902001)2.60079437
132macrophage activation (GO:0042116)2.59914486
133proline transport (GO:0015824)2.59019092
134detection of other organism (GO:0098543)2.58679082
135* regulation of glutamate receptor signaling pathway (GO:1900449)2.57797755
136cellular extravasation (GO:0045123)2.57781562
137L-alpha-amino acid transmembrane transport (GO:1902475)2.56969742
138regulation of gamma-delta T cell activation (GO:0046643)2.56619464
139ceramide catabolic process (GO:0046514)2.55885412
140tyrosine metabolic process (GO:0006570)2.55208068
141positive regulation of fatty acid oxidation (GO:0046321)2.54580195
142synaptic vesicle docking involved in exocytosis (GO:0016081)2.54265885
143JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.54264041
144Rap protein signal transduction (GO:0032486)2.54144328
1452-oxoglutarate metabolic process (GO:0006103)2.53625628
146amino-acid betaine metabolic process (GO:0006577)2.53577393
147positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.52321867
148positive regulation of T-helper cell differentiation (GO:0045624)2.51190420
149regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.51046257
150negative regulation of lipase activity (GO:0060192)2.50950094
151regulation of T-helper 2 cell differentiation (GO:0045628)2.49498199
152drug catabolic process (GO:0042737)2.49135499
153positive regulation of chemokine biosynthetic process (GO:0045080)2.48341013
154response to lipoprotein particle (GO:0055094)2.48328281
155B cell mediated immunity (GO:0019724)2.48308806
156neutral lipid catabolic process (GO:0046461)2.48034498
157acylglycerol catabolic process (GO:0046464)2.48034498
158negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.47780048
159amino sugar catabolic process (GO:0046348)2.47519473
160negative regulation of cytokine production involved in immune response (GO:0002719)2.47429098
161apoptotic cell clearance (GO:0043277)2.47393229
162regulation of cholesterol storage (GO:0010885)2.46136957
163regulation of lipid catabolic process (GO:0050994)2.44770281
164cellular amino acid catabolic process (GO:0009063)2.44091241
165regulation of mast cell activation (GO:0033003)2.44035789
166aromatic amino acid family metabolic process (GO:0009072)2.43883302
167acetyl-CoA metabolic process (GO:0006084)2.43246049
168complement activation (GO:0006956)2.43118931
169regulation of antigen processing and presentation (GO:0002577)2.42803524
170phagocytosis, engulfment (GO:0006911)2.42267327
171response to nerve growth factor (GO:1990089)2.42021091
172cellular response to nerve growth factor stimulus (GO:1990090)2.42021091
173regulation of membrane protein ectodomain proteolysis (GO:0051043)2.41627073
174gamma-aminobutyric acid transport (GO:0015812)2.41397713
175activation of protein kinase A activity (GO:0034199)2.40708373
176regulation of regulated secretory pathway (GO:1903305)2.40618684
177arginine metabolic process (GO:0006525)2.39586741
178cellular hyperosmotic response (GO:0071474)2.39429388
179response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.39337846
180response to host immune response (GO:0052572)2.39337846
181positive regulation of interferon-alpha production (GO:0032727)2.37617298
182estrogen biosynthetic process (GO:0006703)2.37280093
183lipoprotein transport (GO:0042953)2.37094866
184mannose metabolic process (GO:0006013)2.36994325
185positive regulation of antigen processing and presentation (GO:0002579)2.36911829
186dendritic spine morphogenesis (GO:0060997)2.36367848
187neurotransmitter secretion (GO:0007269)2.36071017
188exploration behavior (GO:0035640)2.35799230
189detection of external biotic stimulus (GO:0098581)2.35226280
190regulation of neuronal synaptic plasticity (GO:0048168)2.34819831
191endothelium development (GO:0003158)2.34784455
192surfactant homeostasis (GO:0043129)2.34779335
193barbed-end actin filament capping (GO:0051016)2.34314007
194positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.33716910
195negative regulation of granulocyte differentiation (GO:0030853)2.33465130
196regulation of interferon-beta biosynthetic process (GO:0045357)2.32305619
197negative regulation of sodium ion transport (GO:0010766)2.31783871
198lysosome organization (GO:0007040)2.30899413

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.91640914
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.04334899
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.64563628
4* RXR_22158963_ChIP-Seq_LIVER_Mouse3.63399612
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.43652129
6GATA1_22025678_ChIP-Seq_K562_Human3.28998719
7IRF8_27001747_Chip-Seq_BMDM_Mouse3.27540632
8* EGR1_19374776_ChIP-ChIP_THP-1_Human3.13659464
9* LXR_22158963_ChIP-Seq_LIVER_Mouse3.09568779
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.00225138
11* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.98543930
12SCL_19346495_ChIP-Seq_HPC-7_Human2.90328814
13FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.66522199
14PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.64721329
15NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.62121844
16NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.57770490
17VDR_24787735_ChIP-Seq_THP-1_Human2.53731509
18EZH2_22144423_ChIP-Seq_EOC_Human2.41868266
19NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.40708244
20MYB_21317192_ChIP-Seq_ERMYB_Mouse2.34888308
21MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.19936532
22RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.12895997
23IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.06269933
24DROSHA_22980978_ChIP-Seq_HELA_Human2.02934630
25KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.86542802
26KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.86542802
27KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.86542802
28EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.86012703
29SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.85838055
30RARB_27405468_Chip-Seq_BRAIN_Mouse1.84406257
31SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.80630803
32ERG_21242973_ChIP-ChIP_JURKAT_Human1.77034839
33STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.75489090
34MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.75398000
35GATA2_21666600_ChIP-Seq_HMVEC_Human1.73561593
36EGR1_23403033_ChIP-Seq_LIVER_Mouse1.73031393
37EZH2_18974828_ChIP-Seq_MESCs_Mouse1.72551843
38RNF2_18974828_ChIP-Seq_MESCs_Mouse1.72551843
39* SPI1_23127762_ChIP-Seq_K562_Human1.72071240
40THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.70728036
41VDR_24763502_ChIP-Seq_THP-1_Human1.69239275
42JARID2_20075857_ChIP-Seq_MESCs_Mouse1.68375683
43SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.68361207
44GBX2_23144817_ChIP-Seq_PC3_Human1.68153796
45FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.67153459
46GATA1_19941826_ChIP-Seq_K562_Human1.65475532
47* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.65176379
48NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.64742913
49TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.64646687
50STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.58708893
51SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.58698513
52JARID2_20064375_ChIP-Seq_MESCs_Mouse1.57583324
53SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.54676270
54* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.52622137
55* REST_21632747_ChIP-Seq_MESCs_Mouse1.49866222
56SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.48645157
57ESR2_21235772_ChIP-Seq_MCF-7_Human1.48452480
58ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.48040651
59KDM2B_26808549_Chip-Seq_K562_Human1.43584359
60* FOXA2_19822575_ChIP-Seq_HepG2_Human1.41962252
61* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.39129449
62ZFP281_18757296_ChIP-ChIP_E14_Mouse1.38731214
63EZH2_27294783_Chip-Seq_ESCs_Mouse1.35812077
64* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.35654182
65* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.34640281
66SUZ12_27294783_Chip-Seq_ESCs_Mouse1.34192051
67BRD4_27068464_Chip-Seq_AML-cells_Mouse1.32916931
68* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.32390429
69GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.31206551
70GATA1_19941827_ChIP-Seq_MEL_Mouse1.31205332
71BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.31034719
72IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.30526200
73CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.30046616
74RNF2_27304074_Chip-Seq_ESCs_Mouse1.28722921
75PU_27001747_Chip-Seq_BMDM_Mouse1.27641923
76* REST_18959480_ChIP-ChIP_MESCs_Mouse1.27557880
77TCF7_22412390_ChIP-Seq_EML_Mouse1.27270197
78EED_16625203_ChIP-ChIP_MESCs_Mouse1.27269881
79* CLOCK_20551151_ChIP-Seq_293T_Human1.27227042
80TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.27095139
81FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.26211219
82SALL4_18804426_ChIP-ChIP_XEN_Mouse1.26137165
83* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.24994471
84DNAJC2_21179169_ChIP-ChIP_NT2_Human1.24422500
85* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.23673041
86* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.23518615
87WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.22618355
88AHR_22903824_ChIP-Seq_MCF-7_Human1.20150311
89EZH2_27304074_Chip-Seq_ESCs_Mouse1.19438629
90* GATA2_19941826_ChIP-Seq_K562_Human1.19106818
91LXR_22292898_ChIP-Seq_THP-1_Human1.16525333
92NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.15097066
93SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.14152511
94GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13901917
95* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.13801732
96NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.11928381
97* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.11768459
98* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.11768459
99ZNF263_19887448_ChIP-Seq_K562_Human1.09256426
100RUNX_20019798_ChIP-Seq_JUKART_Human1.08684348
101CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.08560383
102KDM2B_26808549_Chip-Seq_SUP-B15_Human1.07637280
103ARNT_22903824_ChIP-Seq_MCF-7_Human1.06317377
104SPI1_23547873_ChIP-Seq_NB4_Human1.05390041
105WT1_19549856_ChIP-ChIP_CCG9911_Human1.04490564
106ESR1_20079471_ChIP-ChIP_T-47D_Human1.04237411
107SMAD_19615063_ChIP-ChIP_OVARY_Human1.03305396
108* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.03280037
109ZFP281_27345836_Chip-Seq_ESCs_Mouse1.02245604
110NR3C1_23031785_ChIP-Seq_PC12_Mouse1.02140798
111RARG_19884340_ChIP-ChIP_MEFs_Mouse1.01999497
112AR_21572438_ChIP-Seq_LNCaP_Human1.01996252
113STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.01037621
114ESR1_15608294_ChIP-ChIP_MCF-7_Human1.00288608
115CDX2_19796622_ChIP-Seq_MESCs_Mouse0.99619458
116* NFIB_24661679_ChIP-Seq_LUNG_Mouse0.99464470
117* AR_19668381_ChIP-Seq_PC3_Human0.99226029
118* SOX2_21211035_ChIP-Seq_LN229_Gbm0.99012937
119* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.97904898
120RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.97823210
121VDR_21846776_ChIP-Seq_THP-1_Human0.97667872
122IKZF1_21737484_ChIP-ChIP_HCT116_Human0.97627550
123LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.96339474
124STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.96307375
125PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.95850986
126KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.95067487
127* SMAD4_21741376_ChIP-Seq_HESCs_Human0.94988102
128ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.94891525
129CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.94714512
130ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.94464002
131CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.92970591
132ESR1_21235772_ChIP-Seq_MCF-7_Human0.92413207
133* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.91683259
134* RING1B_27294783_Chip-Seq_ESCs_Mouse0.91486926
135RUNX1_22412390_ChIP-Seq_EML_Mouse0.91352287
136* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.90228482
137* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89816716
138SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.89295388
139GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88844203
140* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.88668176
141PIAS1_25552417_ChIP-Seq_VCAP_Human0.88655732
142CREB1_26743006_Chip-Seq_LNCaP_Human0.87972364
143CTCF_27219007_Chip-Seq_Bcells_Human0.86912509
144TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.86794250
145* SOX2_20726797_ChIP-Seq_SW620_Human0.86230529
146* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.86212222
147SMAD3_21741376_ChIP-Seq_HESCs_Human0.85969716
148* SMAD4_21799915_ChIP-Seq_A2780_Human0.85554214
149CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.84938073
150VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.83808925
151LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.83134994
152ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.83087768
153EGR1_19032775_ChIP-ChIP_M12_Human0.82832906
154TP53_16413492_ChIP-PET_HCT116_Human0.82250521
155GATA1_19941827_ChIP-Seq_MEL86_Mouse0.82021433
156KDM2B_26808549_Chip-Seq_DND41_Human0.81657717
157TRIM28_21343339_ChIP-Seq_HEK293_Human0.81038136
158EP300_21415370_ChIP-Seq_HL-1_Mouse0.80142830
159RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.79901032
160RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.79553774
161TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.79458716
162RING1B_27294783_Chip-Seq_NPCs_Mouse0.79327478
163KDM2B_26808549_Chip-Seq_JURKAT_Human0.79186536
164KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.78490526
165* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.78142626
166PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.76891257
167FOXO3_23340844_ChIP-Seq_DLD1_Human0.75619486
168HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.74878740
169NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.74698130

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.43555057
2MP0005360_urolithiasis4.49909616
3MP0004859_abnormal_synaptic_plasticity4.15084173
4MP0005085_abnormal_gallbladder_physiolo4.11146019
5MP0005365_abnormal_bile_salt4.08634316
6MP0003300_gastrointestinal_ulcer3.60907949
7MP0010329_abnormal_lipoprotein_level2.94446131
8MP0003724_increased_susceptibility_to2.90103596
9MP0008875_abnormal_xenobiotic_pharmacok2.88514167
10MP0003252_abnormal_bile_duct2.63707533
11MP0005397_hematopoietic_system_phenotyp2.57988427
12MP0001545_abnormal_hematopoietic_system2.57988427
13MP0009278_abnormal_bone_marrow2.55096455
14MP0005083_abnormal_biliary_tract2.54599051
15MP0002148_abnormal_hypersensitivity_rea2.47121779
16MP0003436_decreased_susceptibility_to2.44193325
17MP0002822_catalepsy2.41989754
18MP0006082_CNS_inflammation2.38751308
19MP0002419_abnormal_innate_immunity2.35267582
20MP0004858_abnormal_nervous_system2.28155962
21MP0001835_abnormal_antigen_presentation2.22809563
22* MP0003635_abnormal_synaptic_transmissio2.14156356
23MP0008004_abnormal_stomach_pH2.13079991
24MP0003705_abnormal_hypodermis_morpholog2.06373829
25MP0005387_immune_system_phenotype2.04101057
26MP0001790_abnormal_immune_system2.04101057
27MP0003191_abnormal_cellular_cholesterol2.01318399
28MP0009840_abnormal_foam_cell2.00053718
29MP0004130_abnormal_muscle_cell1.98851978
30MP0002998_abnormal_bone_remodeling1.96335124
31MP0002909_abnormal_adrenal_gland1.92585268
32MP0009780_abnormal_chondrocyte_physiolo1.92136017
33MP0009785_altered_susceptibility_to1.90687680
34MP0002063_abnormal_learning/memory/cond1.87678511
35MP0005464_abnormal_platelet_physiology1.87454595
36MP0000569_abnormal_digit_pigmentation1.84651436
37MP0003329_amyloid_beta_deposits1.84006445
38MP0004270_analgesia1.82735354
39MP0000604_amyloidosis1.81357149
40MP0005025_abnormal_response_to1.75830635
41MP0002118_abnormal_lipid_homeostasis1.74098695
42MP0006054_spinal_hemorrhage1.71651847
43MP0005000_abnormal_immune_tolerance1.70764343
44MP0005332_abnormal_amino_acid1.69184168
45MP0008961_abnormal_basal_metabolism1.65595392
46MP0002138_abnormal_hepatobiliary_system1.65500347
47MP0009745_abnormal_behavioral_response1.62462765
48MP0003195_calcinosis1.61006843
49MP0003656_abnormal_erythrocyte_physiolo1.55928612
50MP0004808_abnormal_hematopoietic_stem1.54937321
51MP0000685_abnormal_immune_system1.54743401
52MP0005647_abnormal_sex_gland1.52844027
53MP0002452_abnormal_antigen_presenting1.52023611
54MP0004947_skin_inflammation1.48843051
55MP0010234_abnormal_vibrissa_follicle1.46572235
56MP0001666_abnormal_nutrient_absorption1.44808329
57MP0001533_abnormal_skeleton_physiology1.44197996
58MP0003828_pulmonary_edema1.44166334
59MP0009764_decreased_sensitivity_to1.42855837
60MP0000343_altered_response_to1.42537413
61MP0003453_abnormal_keratinocyte_physiol1.42306524
62MP0002064_seizures1.42115136
63MP0005167_abnormal_blood-brain_barrier1.41644813
64* MP0003075_altered_response_to1.39926262
65MP0000609_abnormal_liver_physiology1.37544518
66MP0002723_abnormal_immune_serum1.35230911
67MP0003880_abnormal_central_pattern1.33765733
68MP0001853_heart_inflammation1.32727250
69MP0003690_abnormal_glial_cell1.30017785
70MP0005671_abnormal_response_to1.29455752
71MP0010352_gastrointestinal_tract_polyps1.29347667
72MP0003091_abnormal_cell_migration1.29195607
73MP0003172_abnormal_lysosome_physiology1.28174954
74MP0002405_respiratory_system_inflammati1.26829399
75MP0005535_abnormal_body_temperature1.26422200
76MP0004019_abnormal_vitamin_homeostasis1.26344477
77MP0002572_abnormal_emotion/affect_behav1.25809134
78MP0001845_abnormal_inflammatory_respons1.20795526
79MP0001501_abnormal_sleep_pattern1.19925223
80MP0005319_abnormal_enzyme/_coenzyme1.17542413
81MP0000465_gastrointestinal_hemorrhage1.17326975
82MP0008469_abnormal_protein_level1.16568932
83MP0001819_abnormal_immune_cell1.16295846
84MP0000920_abnormal_myelination1.15608315
85MP0001800_abnormal_humoral_immune1.15146929
86MP0001968_abnormal_touch/_nociception1.14600452
87MP0002420_abnormal_adaptive_immunity1.14027584
88MP0004510_myositis1.13816301
89MP0005584_abnormal_enzyme/coenzyme_acti1.13268516
90MP0003448_altered_tumor_morphology1.08621754
91MP0003868_abnormal_feces_composition1.08078017
92MP0002254_reproductive_system_inflammat1.07150566
93MP0005248_abnormal_Harderian_gland1.03772547
94MP0003183_abnormal_peptide_metabolism1.03354418
95MP0002733_abnormal_thermal_nociception1.03268716
96MP0005058_abnormal_lysosome_morphology1.01234835
97MP0005670_abnormal_white_adipose1.01042692
98MP0003303_peritoneal_inflammation1.00361381
99MP0010155_abnormal_intestine_physiology0.99658917
100MP0001177_atelectasis0.99159531
101MP0010368_abnormal_lymphatic_system0.99065869
102MP0002078_abnormal_glucose_homeostasis0.98838458
103MP0003633_abnormal_nervous_system0.98512066
104MP0005595_abnormal_vascular_smooth0.98390638
105* MP0004811_abnormal_neuron_physiology0.98019842
106MP0005451_abnormal_body_composition0.97818601
107MP0002837_dystrophic_cardiac_calcinosis0.97030164
108MP0005310_abnormal_salivary_gland0.92392534
109MP0003806_abnormal_nucleotide_metabolis0.92184574
110MP0003879_abnormal_hair_cell0.90844129
111MP0002734_abnormal_mechanical_nocicepti0.89813222
112MP0004885_abnormal_endolymph0.89434829
113MP0005334_abnormal_fat_pad0.88835838
114MP0000383_abnormal_hair_follicle0.88561972
115MP0008874_decreased_physiological_sensi0.88554023
116MP0002735_abnormal_chemical_nociception0.88378347
117MP0001915_intracranial_hemorrhage0.86973186
118MP0001486_abnormal_startle_reflex0.86897199
119MP0002332_abnormal_exercise_endurance0.86520265
120MP0000778_abnormal_nervous_system0.85551611
121MP0010386_abnormal_urinary_bladder0.84859285
122MP0009046_muscle_twitch0.84497501
123MP0005448_abnormal_energy_balance0.84372021
124MP0000716_abnormal_immune_system0.84266499
125MP0010307_abnormal_tumor_latency0.83913787
126MP0003283_abnormal_digestive_organ0.82429318
127MP0004264_abnormal_extraembryonic_tissu0.82275927
128MP0003632_abnormal_nervous_system0.81993916
129MP0003634_abnormal_glial_cell0.81916428
130MP0005187_abnormal_penis_morphology0.81441666
131MP0001756_abnormal_urination0.79675030
132MP0002069_abnormal_eating/drinking_beha0.79628088
133MP0005646_abnormal_pituitary_gland0.79134465
134MP0001440_abnormal_grooming_behavior0.78186237
135MP0002090_abnormal_vision0.76216680
136MP0004782_abnormal_surfactant_physiolog0.75588956
137MP0005666_abnormal_adipose_tissue0.75153767
138MP0010678_abnormal_skin_adnexa0.74726223
139MP0005386_behavior/neurological_phenoty0.74329567
140MP0004924_abnormal_behavior0.74329567
141MP0005076_abnormal_cell_differentiation0.73942193
142MP0002876_abnormal_thyroid_physiology0.73054710
143MP0002736_abnormal_nociception_after0.73043496
144MP0002557_abnormal_social/conspecific_i0.72909365
145MP0000689_abnormal_spleen_morphology0.72365554
146MP0003631_nervous_system_phenotype0.71429623
147MP0002971_abnormal_brown_adipose0.70011230
148MP0009643_abnormal_urine_homeostasis0.69575005
149MP0000955_abnormal_spinal_cord0.69408528
150MP0009763_increased_sensitivity_to0.68928351
151MP0002272_abnormal_nervous_system0.68842490
152MP0000371_diluted_coat_color0.67906140
153MP0002398_abnormal_bone_marrow0.67531880
154MP0002133_abnormal_respiratory_system0.67405239
155MP0005388_respiratory_system_phenotype0.67405239
156* MP0005166_decreased_susceptibility_to0.67366883
157MP0002184_abnormal_innervation0.67005668
158MP0001970_abnormal_pain_threshold0.66929672
159MP0005164_abnormal_response_to0.66012221
160MP0003953_abnormal_hormone_level0.64949720
161MP0001881_abnormal_mammary_gland0.64309968
162MP0003795_abnormal_bone_structure0.64151785
163MP0004883_abnormal_blood_vessel0.63828420
164MP0009765_abnormal_xenobiotic_induced0.63580081
165MP0005423_abnormal_somatic_nervous0.63337603
166MP0006276_abnormal_autonomic_nervous0.61983983
167MP0001984_abnormal_olfaction0.61616552
168MP0002429_abnormal_blood_cell0.61066725
169MP0004185_abnormal_adipocyte_glucose0.60966209
170MP0003941_abnormal_skin_development0.60802433
171MP0005375_adipose_tissue_phenotype0.60687095
172MP0001851_eye_inflammation0.60376006
173MP0009115_abnormal_fat_cell0.60118431
174MP0005409_darkened_coat_color0.59460690
175MP0005390_skeleton_phenotype0.59330939
176MP0005165_increased_susceptibility_to0.57551780

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of liposaccharide metabolism (HP:0010968)6.05521584
2Abnormality of glycosphingolipid metabolism (HP:0004343)6.05521584
3Abnormality of glycolipid metabolism (HP:0010969)6.05521584
4Deep venous thrombosis (HP:0002625)5.18578632
5Complement deficiency (HP:0004431)4.51039744
6Increased cerebral lipofuscin (HP:0011813)4.42297179
7Vacuolated lymphocytes (HP:0001922)4.28550337
8Disinhibition (HP:0000734)4.20884734
9Intrahepatic cholestasis (HP:0001406)3.88083507
10Xanthomatosis (HP:0000991)3.84300055
11Abnormality of macrophages (HP:0004311)3.80236756
12Dysostosis multiplex (HP:0000943)3.78716344
13Loss of speech (HP:0002371)3.75642101
14Abnormality of monocarboxylic acid metabolism (HP:0010996)3.69465628
15Abnormality of aromatic amino acid family metabolism (HP:0004338)3.69199091
16Prolonged partial thromboplastin time (HP:0003645)3.52275765
17Eczematoid dermatitis (HP:0000976)3.51554343
18Increased neuronal autofluorescent lipopigment (HP:0002074)3.41053080
19Recurrent abscess formation (HP:0002722)3.40439786
20Abnormality of complement system (HP:0005339)3.35525376
21Hematochezia (HP:0002573)3.34331226
22Recurrent bacterial skin infections (HP:0005406)3.29525105
23Mutism (HP:0002300)3.28986548
24Epidermoid cyst (HP:0200040)3.27113086
25Hyperlipoproteinemia (HP:0010980)3.26792699
26Myokymia (HP:0002411)3.21030056
27Interstitial pulmonary disease (HP:0006530)3.02039893
28Joint hemorrhage (HP:0005261)2.98709735
29Systemic lupus erythematosus (HP:0002725)2.96350014
30Abnormality of the common coagulation pathway (HP:0010990)2.93796201
31Abnormality of the lower motor neuron (HP:0002366)2.91451955
32Ketosis (HP:0001946)2.89999883
33Turricephaly (HP:0000262)2.89549595
34Inappropriate behavior (HP:0000719)2.84799345
35Hypobetalipoproteinemia (HP:0003563)2.84626329
36Apathy (HP:0000741)2.80478922
37Abnormality of glutamine family amino acid metabolism (HP:0010902)2.66164720
38Diminished motivation (HP:0000745)2.65844045
39Autoimmune thrombocytopenia (HP:0001973)2.65574572
40Cerebral inclusion bodies (HP:0100314)2.61497240
41Abnormality of the periventricular white matter (HP:0002518)2.60438435
42Abnormality of the lumbar spine (HP:0100712)2.59267843
43Ketoacidosis (HP:0001993)2.58590678
44Focal motor seizures (HP:0011153)2.56643920
45Hypercholesterolemia (HP:0003124)2.56414663
46Thoracic kyphosis (HP:0002942)2.56150723
47Abnormality of the vasculature of the conjunctiva (HP:0008054)2.55702890
48Skin nodule (HP:0200036)2.55369321
49Hypoalphalipoproteinemia (HP:0003233)2.54883592
50Focal seizures (HP:0007359)2.54322343
51Torticollis (HP:0000473)2.53116280
52Hyperglycinemia (HP:0002154)2.50198159
53Spontaneous hematomas (HP:0007420)2.48958852
54Gout (HP:0001997)2.48653477
55Mediastinal lymphadenopathy (HP:0100721)2.48212255
56Hyperammonemia (HP:0001987)2.47531058
57Glomerulonephritis (HP:0000099)2.44783241
58Hypolipoproteinemia (HP:0010981)2.42949686
59Neurofibrillary tangles (HP:0002185)2.41484247
60Hyperglycinuria (HP:0003108)2.37973671
61Recurrent gram-negative bacterial infections (HP:0005420)2.36216322
62Orchitis (HP:0100796)2.35953499
63Neuronal loss in central nervous system (HP:0002529)2.35403692
64Supranuclear gaze palsy (HP:0000605)2.35173432
65Nuclear cataract (HP:0100018)2.32810421
66Agnosia (HP:0010524)2.32506216
67Esophageal varix (HP:0002040)2.29483777
68Increased CSF protein (HP:0002922)2.28156928
69Amyloidosis (HP:0011034)2.27607451
70Myositis (HP:0100614)2.26063555
71Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.25179502
72Focal dystonia (HP:0004373)2.24928752
73Action tremor (HP:0002345)2.24391401
74Retrobulbar optic neuritis (HP:0100654)2.23067163
75Optic neuritis (HP:0100653)2.23067163
76Thoracolumbar scoliosis (HP:0002944)2.21449598
77Abnormality of sulfur amino acid metabolism (HP:0004339)2.21142452
78Craniofacial dystonia (HP:0012179)2.20585485
79Status epilepticus (HP:0002133)2.20381331
80Mitral stenosis (HP:0001718)2.19741825
81Hypoglycemic coma (HP:0001325)2.19221122
82Retinal atrophy (HP:0001105)2.18493675
83Abnormality of glycine metabolism (HP:0010895)2.13970810
84Abnormality of serine family amino acid metabolism (HP:0010894)2.13970810
85Gingivitis (HP:0000230)2.13942873
86Lymphangioma (HP:0100764)2.12758094
87Visual hallucinations (HP:0002367)2.10546285
88Impaired social interactions (HP:0000735)2.09880493
89Abnormal social behavior (HP:0012433)2.09880493
90Progressive visual loss (HP:0000529)2.08152069
91Long toe (HP:0010511)2.06614811
92Recurrent skin infections (HP:0001581)2.06520327
93Delayed CNS myelination (HP:0002188)2.04751805
94Neonatal onset (HP:0003623)2.04544586
95Abnormality of the intrinsic pathway (HP:0010989)2.03314348
96Abnormality of the Achilles tendon (HP:0005109)2.02956587
97Nephritis (HP:0000123)2.02774666
98Spontaneous abortion (HP:0005268)2.02258698
99Stroke (HP:0001297)2.00050338
100Peripheral demyelination (HP:0011096)1.99027250
101Hepatocellular carcinoma (HP:0001402)1.97667296
102Postural instability (HP:0002172)1.97601420
103Abnormality of purine metabolism (HP:0004352)1.97600592
104Spastic diplegia (HP:0001264)1.96629819
105Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.96534602
106Sensorimotor neuropathy (HP:0007141)1.96475816
107Abnormality of the fingertips (HP:0001211)1.96283274
108Myocardial infarction (HP:0001658)1.88213376
109Bronchomalacia (HP:0002780)1.87419211
110Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.85780337
111Hemorrhage of the eye (HP:0011885)1.84445828
112Global brain atrophy (HP:0002283)1.83929135
113Hypoglycemic seizures (HP:0002173)1.83899557
114Upper motor neuron abnormality (HP:0002127)1.83305008
115Depression (HP:0000716)1.83249301
116Poor eye contact (HP:0000817)1.82828394
117Purpura (HP:0000979)1.82654149
118Keratoconjunctivitis sicca (HP:0001097)1.82431201
119Generalized tonic-clonic seizures (HP:0002069)1.81238373
120Fat malabsorption (HP:0002630)1.80178091
121Resting tremor (HP:0002322)1.79039472
122Gingival bleeding (HP:0000225)1.78891897
123Acute lymphatic leukemia (HP:0006721)1.78666772
124Excessive salivation (HP:0003781)1.77857032
125Drooling (HP:0002307)1.77857032
126Protruding tongue (HP:0010808)1.77343132
127Impaired vibration sensation in the lower limbs (HP:0002166)1.77025390
128Recurrent fungal infections (HP:0002841)1.76109597
129Conjugated hyperbilirubinemia (HP:0002908)1.75625411
130Cortical dysplasia (HP:0002539)1.74986600
131Hepatoblastoma (HP:0002884)1.74723926
132Death in childhood (HP:0003819)1.74297953
133Stomatitis (HP:0010280)1.73712098
134Xerostomia (HP:0000217)1.73120863
135Shallow orbits (HP:0000586)1.72806389
136Pulmonary infiltrates (HP:0002113)1.72693995
137Abnormality of nucleobase metabolism (HP:0010932)1.72651438
138Striae distensae (HP:0001065)1.72578379
139Personality changes (HP:0000751)1.72544464
140Thickened calvaria (HP:0002684)1.72094311
141Urinary incontinence (HP:0000020)1.71045697
142Basal ganglia calcification (HP:0002135)1.70998689
143Hemoptysis (HP:0002105)1.70877732
144Hepatosplenomegaly (HP:0001433)1.70566857
145Neoplasm of the tracheobronchial system (HP:0100552)1.69995028
146Dementia (HP:0000726)1.69740068
147Hyperventilation (HP:0002883)1.69588010
148Mucopolysacchariduria (HP:0008155)1.68849465
149Urinary glycosaminoglycan excretion (HP:0003541)1.68849465
150Amaurosis fugax (HP:0100576)1.68615921
151Cerebral aneurysm (HP:0004944)1.67994124
152Abnormality of the thoracic spine (HP:0100711)1.67148509
153Absence seizures (HP:0002121)1.66363868
154Pathologic fracture (HP:0002756)1.65797867
155Hydroxyprolinuria (HP:0003080)1.65457521
156Abnormality of proline metabolism (HP:0010907)1.65457521
157Polygenic inheritance (HP:0010982)1.64892471
158Cellulitis (HP:0100658)1.64636048
159Upper limb amyotrophy (HP:0009129)1.64460383
160Distal upper limb amyotrophy (HP:0007149)1.64460383
161Keratoconjunctivitis (HP:0001096)1.63913746
162Abnormality of mucopolysaccharide metabolism (HP:0011020)1.63780778
163Abnormality of polysaccharide metabolism (HP:0011012)1.63780778
164Abnormality of glycosaminoglycan metabolism (HP:0004371)1.63780778
165Hypsarrhythmia (HP:0002521)1.61573593
166EEG with generalized epileptiform discharges (HP:0011198)1.61293538
167Epileptiform EEG discharges (HP:0011182)1.61012213
168Epistaxis (HP:0000421)1.60851829
169Increased serum ferritin (HP:0003281)1.60520028
170Abnormality of iron homeostasis (HP:0011031)1.59800929
171Asymmetric septal hypertrophy (HP:0001670)1.59003106
172Portal hypertension (HP:0001409)1.58800165
173Premature loss of primary teeth (HP:0006323)1.58083379
174Recurrent viral infections (HP:0004429)1.57343542
175Acrocyanosis (HP:0001063)1.56289843
176Vertigo (HP:0002321)1.56266094
177Progressive neurologic deterioration (HP:0002344)1.55844285
178Papillary thyroid carcinoma (HP:0002895)1.54752809
179Thrombocytosis (HP:0001894)1.52403914
180Vasculitis (HP:0002633)1.50875570
181Thrombophlebitis (HP:0004418)1.50509225

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA43.51362000
2MATK3.26394706
3NTRK33.04352908
4MAP3K92.87990398
5MARK12.72925145
6TRIB32.62654282
7MAP3K142.58344965
8BLK2.40555453
9KSR22.35849451
10RIPK12.31215385
11SIK12.26298015
12RIPK42.04847983
13PKN22.04198870
14MAP3K42.01392989
15TBK11.96966417
16MAP2K41.87597776
17PRKD31.86174638
18IRAK31.84597899
19CAMKK11.82734781
20NTRK11.81610853
21MINK11.79808978
22TYK21.79479501
23MAP3K21.78134542
24* DAPK21.76005973
25CAMK1D1.75130136
26CAMK1G1.72971055
27TGFBR21.71235563
28PAK61.69985984
29SIK21.55831343
30KIT1.55774505
31CSF1R1.55014943
32GRK71.54777974
33INSRR1.52507545
34BCKDK1.49828920
35ERN11.48480459
36KSR11.47741210
37CSK1.47460963
38BRD41.46783566
39MAP3K61.45457017
40RET1.43932231
41ACVR1B1.43343233
42LATS21.42819380
43CDC42BPA1.39171713
44STK381.37029135
45JAK31.34552716
46NTRK21.29874549
47MAP4K11.29766910
48MAP2K31.27222526
49SGK31.26252377
50FGFR41.25228063
51TNIK1.24600189
52PDGFRA1.23634631
53TIE11.23061239
54YES11.19114600
55EPHA31.18756955
56IRAK41.16670390
57IKBKE1.15795375
58PTK61.08853627
59CDK51.08694851
60SGK21.07656654
61MAP3K51.06944842
62TAOK11.06561103
63MAP3K31.06283802
64MAP3K71.05837893
65MAP2K71.05041773
66IKBKB1.04596605
67MKNK11.04059053
68FER1.02001374
69FGFR20.97504425
70LMTK20.96845744
71PRKCH0.94769750
72ERBB20.93998329
73MST1R0.92673989
74PRKCZ0.90713404
75TAOK20.90638082
76SGK2230.88602528
77SGK4940.88602528
78STK38L0.88494369
79SYK0.87437674
80MAPK70.87408196
81IRAK20.87331694
82LYN0.86769024
83HIPK20.85853428
84CDK120.85591524
85PRKG20.85204782
86MAP3K10.85074980
87MAP3K130.84473216
88PTK20.83002916
89IRAK10.82763736
90ZAP700.82133007
91TAF10.81604510
92PTK2B0.79211000
93TAOK30.79183899
94JAK20.78825776
95FES0.78610716
96HCK0.78469834
97PDPK10.78435230
98EPHB20.77147305
99PRKCG0.76514175
100ERBB40.76033842
101PHKG20.74859630
102PHKG10.74859630
103TYRO30.74443908
104GRK50.74412592
105DDR20.72937911
106BMPR20.70312036
107TEC0.70190121
108MAP2K10.70185197
109CAMK40.69669603
110BMX0.68902893
111PRKD20.68776797
112SCYL20.67091684
113PDGFRB0.67046177
114PAK30.65112538
115LATS10.65106968
116ICK0.64780382
117CHUK0.64086894
118STK110.63102677
119SGK10.62311698
120PDK10.61466149
121JAK10.60238922
122FGFR30.59968822
123NME20.58025424
124LCK0.56525800
125CAMK10.55029046
126ALK0.54668589
127FGR0.53033977
128WNK30.52655873
129BTK0.52341469
130CDK60.51687084
131NEK10.51375233
132PIM10.50345592
133FYN0.49738149
134PRKACG0.49412983
135PINK10.49072369
136MARK20.48474958
137* RPS6KA30.47610599
138FGFR10.47196031
139CAMK2A0.46941695
140ABL10.46851376
141MAP3K110.45944372
142MTOR0.45650764
143PRKAA10.45068477
144TTN0.44267663
145INSR0.42781836
146DYRK1B0.40525655
147* DAPK10.40266932
148MAP3K100.39932037
149IGF1R0.39623977
150ABL20.39518913
151STK100.38846253
152EGFR0.38844738
153SRC0.37984433
154PRPF4B0.37833567
155GSK3A0.36358966
156MAPK30.36197090
157NEK90.35127330

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.77316205
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.19424687
3Other glycan degradation_Homo sapiens_hsa005113.00638562
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.96430600
5Arginine biosynthesis_Homo sapiens_hsa002202.67447215
6Lysosome_Homo sapiens_hsa041422.46123073
7Leishmaniasis_Homo sapiens_hsa051402.38468363
8Asthma_Homo sapiens_hsa053102.35680435
9Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.22036940
10Complement and coagulation cascades_Homo sapiens_hsa046102.21511148
11Allograft rejection_Homo sapiens_hsa053302.09247329
12Osteoclast differentiation_Homo sapiens_hsa043802.06627447
13Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.03253005
14Rheumatoid arthritis_Homo sapiens_hsa053232.01845295
15Glycosaminoglycan degradation_Homo sapiens_hsa005311.87110039
16Toll-like receptor signaling pathway_Homo sapiens_hsa046201.86505340
17Tuberculosis_Homo sapiens_hsa051521.85407261
18Staphylococcus aureus infection_Homo sapiens_hsa051501.83027750
19Type I diabetes mellitus_Homo sapiens_hsa049401.77884917
20Tryptophan metabolism_Homo sapiens_hsa003801.76391397
21Intestinal immune network for IgA production_Homo sapiens_hsa046721.72928946
22Graft-versus-host disease_Homo sapiens_hsa053321.69200654
23Pertussis_Homo sapiens_hsa051331.66910118
24Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.66611506
25Bile secretion_Homo sapiens_hsa049761.65724116
26Fatty acid degradation_Homo sapiens_hsa000711.64324497
27PPAR signaling pathway_Homo sapiens_hsa033201.61544534
28Autoimmune thyroid disease_Homo sapiens_hsa053201.61526135
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.60154609
30Butanoate metabolism_Homo sapiens_hsa006501.59270556
31Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.50087183
32Toxoplasmosis_Homo sapiens_hsa051451.45374192
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.44626366
34Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.43618416
35Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.43481984
36Synaptic vesicle cycle_Homo sapiens_hsa047211.42384845
37NOD-like receptor signaling pathway_Homo sapiens_hsa046211.39874702
38Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.39584518
392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.38742655
40TNF signaling pathway_Homo sapiens_hsa046681.33892340
41Phagosome_Homo sapiens_hsa041451.32837261
42NF-kappa B signaling pathway_Homo sapiens_hsa040641.32781375
43African trypanosomiasis_Homo sapiens_hsa051431.31451665
44Influenza A_Homo sapiens_hsa051641.29784303
45Caffeine metabolism_Homo sapiens_hsa002321.28815215
46Malaria_Homo sapiens_hsa051441.28563367
47Fatty acid metabolism_Homo sapiens_hsa012121.27950787
48B cell receptor signaling pathway_Homo sapiens_hsa046621.24067135
49Type II diabetes mellitus_Homo sapiens_hsa049301.20874668
50Legionellosis_Homo sapiens_hsa051341.17941155
51Propanoate metabolism_Homo sapiens_hsa006401.15214588
52Olfactory transduction_Homo sapiens_hsa047401.14403535
53GABAergic synapse_Homo sapiens_hsa047271.13402955
54Salmonella infection_Homo sapiens_hsa051321.12746522
55Peroxisome_Homo sapiens_hsa041461.11669973
56Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.11608253
57Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.10667028
58Acute myeloid leukemia_Homo sapiens_hsa052211.09480427
59Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.09112397
60Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.08602724
61Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.07558182
62RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.05692863
63Circadian entrainment_Homo sapiens_hsa047131.04490942
64AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.03550498
65Nicotine addiction_Homo sapiens_hsa050331.03385526
66beta-Alanine metabolism_Homo sapiens_hsa004101.03132559
67Viral myocarditis_Homo sapiens_hsa054161.02764148
68Phenylalanine metabolism_Homo sapiens_hsa003601.01274043
69Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.01045616
70Pentose and glucuronate interconversions_Homo sapiens_hsa000401.00437939
71Hepatitis C_Homo sapiens_hsa051601.00338835
72Prolactin signaling pathway_Homo sapiens_hsa049170.99106678
73Prion diseases_Homo sapiens_hsa050200.98403062
74Jak-STAT signaling pathway_Homo sapiens_hsa046300.95841175
75Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.93866535
76Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.93240373
77Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.93182684
78Herpes simplex infection_Homo sapiens_hsa051680.92414966
79Fatty acid biosynthesis_Homo sapiens_hsa000610.91860030
80Long-term potentiation_Homo sapiens_hsa047200.90712519
81Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.90681535
82Lysine degradation_Homo sapiens_hsa003100.89666861
83Glutamatergic synapse_Homo sapiens_hsa047240.89202899
84Chemokine signaling pathway_Homo sapiens_hsa040620.89118253
85Antigen processing and presentation_Homo sapiens_hsa046120.89012948
86Morphine addiction_Homo sapiens_hsa050320.88941283
87Aldosterone synthesis and secretion_Homo sapiens_hsa049250.88849625
88Renin-angiotensin system_Homo sapiens_hsa046140.88205151
89Insulin secretion_Homo sapiens_hsa049110.88197238
90Histidine metabolism_Homo sapiens_hsa003400.85161644
91Hematopoietic cell lineage_Homo sapiens_hsa046400.83251420
92Salivary secretion_Homo sapiens_hsa049700.83125661
93ABC transporters_Homo sapiens_hsa020100.82729478
94Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.82354391
95Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.82002753
96Sphingolipid signaling pathway_Homo sapiens_hsa040710.80115241
97Amphetamine addiction_Homo sapiens_hsa050310.79788104
98Insulin resistance_Homo sapiens_hsa049310.79446916
99Cholinergic synapse_Homo sapiens_hsa047250.79168719
100Platelet activation_Homo sapiens_hsa046110.78775674
101Dopaminergic synapse_Homo sapiens_hsa047280.78722364
102Chronic myeloid leukemia_Homo sapiens_hsa052200.77579193
103Hepatitis B_Homo sapiens_hsa051610.75941058
104Sphingolipid metabolism_Homo sapiens_hsa006000.74290132
105Leukocyte transendothelial migration_Homo sapiens_hsa046700.74215663
106Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.73314986
107Renin secretion_Homo sapiens_hsa049240.72653713
108Transcriptional misregulation in cancer_Homo sapiens_hsa052020.72463091
109Chemical carcinogenesis_Homo sapiens_hsa052040.71287486
110Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.70499170
111Starch and sucrose metabolism_Homo sapiens_hsa005000.70278061
112Cocaine addiction_Homo sapiens_hsa050300.70253890
113Adipocytokine signaling pathway_Homo sapiens_hsa049200.68485754
114Tyrosine metabolism_Homo sapiens_hsa003500.68475491
115Gastric acid secretion_Homo sapiens_hsa049710.68178004
116Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.67753256
117Pyruvate metabolism_Homo sapiens_hsa006200.67055785
118Glycerolipid metabolism_Homo sapiens_hsa005610.66465791
119Glioma_Homo sapiens_hsa052140.66352407
120Neurotrophin signaling pathway_Homo sapiens_hsa047220.66281127
121Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.65993290
122Ovarian steroidogenesis_Homo sapiens_hsa049130.64521746
123Measles_Homo sapiens_hsa051620.63495890
124Glucagon signaling pathway_Homo sapiens_hsa049220.63423300
125Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.63005425
126Fat digestion and absorption_Homo sapiens_hsa049750.62959664
127Insulin signaling pathway_Homo sapiens_hsa049100.62826028
128Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.61852029
129Shigellosis_Homo sapiens_hsa051310.60896729
130Long-term depression_Homo sapiens_hsa047300.59275329
131GnRH signaling pathway_Homo sapiens_hsa049120.58307163
132Renal cell carcinoma_Homo sapiens_hsa052110.58188568
133Steroid hormone biosynthesis_Homo sapiens_hsa001400.56908486
134Estrogen signaling pathway_Homo sapiens_hsa049150.56901197
135Oxytocin signaling pathway_Homo sapiens_hsa049210.56564752
136Selenocompound metabolism_Homo sapiens_hsa004500.56435491
137Pancreatic cancer_Homo sapiens_hsa052120.55917256
138mTOR signaling pathway_Homo sapiens_hsa041500.55809634
139Phospholipase D signaling pathway_Homo sapiens_hsa040720.54307557
140Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.53055455
141Carbon metabolism_Homo sapiens_hsa012000.52461290
142Biosynthesis of amino acids_Homo sapiens_hsa012300.52314762
143Dorso-ventral axis formation_Homo sapiens_hsa043200.51779439
144Retinol metabolism_Homo sapiens_hsa008300.51771774
145Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.51741786
146Drug metabolism - other enzymes_Homo sapiens_hsa009830.49618408
147Thyroid hormone synthesis_Homo sapiens_hsa049180.48246777
148AMPK signaling pathway_Homo sapiens_hsa041520.48197965
149Carbohydrate digestion and absorption_Homo sapiens_hsa049730.47843731
150Endometrial cancer_Homo sapiens_hsa052130.47359463
151Ether lipid metabolism_Homo sapiens_hsa005650.47341326
152Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47318219
153Adherens junction_Homo sapiens_hsa045200.47221183
154cAMP signaling pathway_Homo sapiens_hsa040240.46814549
155Melanogenesis_Homo sapiens_hsa049160.46348035
156Apoptosis_Homo sapiens_hsa042100.45104965
157Gap junction_Homo sapiens_hsa045400.44812190
158Amoebiasis_Homo sapiens_hsa051460.44521852
159Central carbon metabolism in cancer_Homo sapiens_hsa052300.44482208
160Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.44087204
161Calcium signaling pathway_Homo sapiens_hsa040200.42835640
162Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.41975604
163Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.41016358
164Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.40670641
165HIF-1 signaling pathway_Homo sapiens_hsa040660.40650894
166ErbB signaling pathway_Homo sapiens_hsa040120.39811756
167Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.39769485
168Collecting duct acid secretion_Homo sapiens_hsa049660.39651033
169Maturity onset diabetes of the young_Homo sapiens_hsa049500.39413202
170Phosphatidylinositol signaling system_Homo sapiens_hsa040700.39171280
171Choline metabolism in cancer_Homo sapiens_hsa052310.37561582
172Rap1 signaling pathway_Homo sapiens_hsa040150.36977698
173Notch signaling pathway_Homo sapiens_hsa043300.36726058
174Non-small cell lung cancer_Homo sapiens_hsa052230.36465917
175MAPK signaling pathway_Homo sapiens_hsa040100.36343765
176* Bladder cancer_Homo sapiens_hsa052190.34694686
177VEGF signaling pathway_Homo sapiens_hsa043700.34233935
178Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.33774043
179Proteoglycans in cancer_Homo sapiens_hsa052050.33374139
180Inositol phosphate metabolism_Homo sapiens_hsa005620.31007856

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