DAPK3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Death-associated protein kinase 3 (DAPK3) induces morphological changes in apoptosis when overexpressed in mammalian cells. These results suggest that DAPK3 may play a role in the induction of apoptosis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.77711431
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.77711431
3maternal placenta development (GO:0001893)4.70311799
4protein localization to endosome (GO:0036010)4.67620376
5pentose-phosphate shunt (GO:0006098)4.16813879
6skin morphogenesis (GO:0043589)4.14184318
7negative regulation of cell size (GO:0045792)4.11860607
8planar cell polarity pathway involved in neural tube closure (GO:0090179)4.06090880
9folic acid-containing compound biosynthetic process (GO:0009396)4.00794379
10antigen processing and presentation of endogenous antigen (GO:0019883)4.00685504
11cell-substrate junction assembly (GO:0007044)3.97005093
12regulation of cholesterol homeostasis (GO:2000188)3.93221872
13regulation of fatty acid beta-oxidation (GO:0031998)3.84560039
14antigen processing and presentation via MHC class Ib (GO:0002475)3.82785938
15stress fiber assembly (GO:0043149)3.77229567
16positive regulation of histone deacetylation (GO:0031065)3.74020913
17barbed-end actin filament capping (GO:0051016)3.73889385
18regulation of translational fidelity (GO:0006450)3.73374557
19endodermal cell differentiation (GO:0035987)3.70515463
20regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.67687048
21glycine metabolic process (GO:0006544)3.64815232
22epithelial cell-cell adhesion (GO:0090136)3.57135292
23positive regulation of triglyceride biosynthetic process (GO:0010867)3.55746561
24NADPH regeneration (GO:0006740)3.53422183
25vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.49068133
26lysine catabolic process (GO:0006554)3.48526427
27lysine metabolic process (GO:0006553)3.48526427
28semaphorin-plexin signaling pathway (GO:0071526)3.47076965
29cytoskeletal anchoring at plasma membrane (GO:0007016)3.44189704
30hemidesmosome assembly (GO:0031581)3.41439158
31retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.38366594
32vascular endothelial growth factor signaling pathway (GO:0038084)3.35581918
33positive regulation of blood vessel endothelial cell migration (GO:0043536)3.31275245
34protein heterotrimerization (GO:0070208)3.30293323
35activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.22926378
36regulation of translational termination (GO:0006449)3.20857167
374-hydroxyproline metabolic process (GO:0019471)3.19324554
38atrioventricular valve morphogenesis (GO:0003181)3.16014075
39positive regulation of nuclease activity (GO:0032075)3.15750825
40sulfur amino acid catabolic process (GO:0000098)3.10789399
41negative regulation of sterol transport (GO:0032372)3.10558639
42negative regulation of cholesterol transport (GO:0032375)3.10558639
43alpha-linolenic acid metabolic process (GO:0036109)3.10494431
44DNA deamination (GO:0045006)3.06858157
45activation of MAPKKK activity (GO:0000185)3.06848300
46cell adhesion mediated by integrin (GO:0033627)3.04079324
47positive regulation of triglyceride metabolic process (GO:0090208)3.03801440
48apoptotic process involved in morphogenesis (GO:0060561)3.02266001
49positive regulation of fatty acid beta-oxidation (GO:0032000)3.02049959
50negative regulation of fibrinolysis (GO:0051918)3.00463873
51galactose catabolic process (GO:0019388)2.96891599
52positive regulation of receptor recycling (GO:0001921)2.96110321
53triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.94602383
54peptidyl-lysine dimethylation (GO:0018027)2.90767982
55COPI coating of Golgi vesicle (GO:0048205)2.90136878
56Golgi transport vesicle coating (GO:0048200)2.90136878
57cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.89850171
58erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.88566601
59L-phenylalanine metabolic process (GO:0006558)2.88566601
60positive regulation of protein deacetylation (GO:0090312)2.88102575
61adhesion of symbiont to host (GO:0044406)2.85136710
62adhesion of symbiont to host cell (GO:0044650)2.84854930
63virion attachment to host cell (GO:0019062)2.84854930
64glucose catabolic process (GO:0006007)2.84680223
65regulation of early endosome to late endosome transport (GO:2000641)2.84243128
66negative regulation of fatty acid transport (GO:2000192)2.84118178
67dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.83484797
68regulation of nuclease activity (GO:0032069)2.82694513
69cell migration involved in heart development (GO:0060973)2.82627645
70apoptotic cell clearance (GO:0043277)2.82261089
71urea cycle (GO:0000050)2.82251734
72urea metabolic process (GO:0019627)2.82251734
73regulation of posttranscriptional gene silencing (GO:0060147)2.81426200
74regulation of gene silencing by miRNA (GO:0060964)2.81426200
75regulation of gene silencing by RNA (GO:0060966)2.81426200
76positive thymic T cell selection (GO:0045059)2.79352268
77regulation of mammary gland epithelial cell proliferation (GO:0033599)2.77425438
78serine family amino acid biosynthetic process (GO:0009070)2.76613588
79negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.76524790
80endothelial cell chemotaxis (GO:0035767)2.76269742
81regulation of fatty acid oxidation (GO:0046320)2.75930483
822-oxoglutarate metabolic process (GO:0006103)2.75754243
83serine family amino acid metabolic process (GO:0009069)2.75099954
84serine family amino acid catabolic process (GO:0009071)2.75093990
85regulation of cholesterol storage (GO:0010885)2.74768536
86peptidyl-proline hydroxylation (GO:0019511)2.74707836
87substrate-dependent cell migration (GO:0006929)2.73738381
88low-density lipoprotein particle clearance (GO:0034383)2.72494826
89protein maturation by protein folding (GO:0022417)2.72494408
90regulation of hippo signaling (GO:0035330)2.72366351
91endocytic recycling (GO:0032456)2.72261187
92negative regulation of lipid transport (GO:0032369)2.71779480
93cysteine metabolic process (GO:0006534)2.71763187
94mannose metabolic process (GO:0006013)2.71531716
95endoplasmic reticulum unfolded protein response (GO:0030968)2.70749111
96peptidyl-arginine omega-N-methylation (GO:0035247)2.69696104
97collagen fibril organization (GO:0030199)2.69017419
98maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.68853554
99protein retention in ER lumen (GO:0006621)2.68778140
100positive regulation of lamellipodium assembly (GO:0010592)2.66939929
101tetrahydrofolate metabolic process (GO:0046653)2.66806653
102L-alpha-amino acid transmembrane transport (GO:1902475)2.66185139
103actin filament bundle assembly (GO:0051017)2.65917831
104actin filament bundle organization (GO:0061572)2.65917831
105protein targeting to plasma membrane (GO:0072661)2.64988254
106collagen metabolic process (GO:0032963)2.64643249
107regulation of gamma-delta T cell differentiation (GO:0045586)2.63769334
108cell-cell junction maintenance (GO:0045217)2.63381946
109endothelial cell morphogenesis (GO:0001886)2.63014136
110mitotic G1 DNA damage checkpoint (GO:0031571)2.62066398
111endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.61987505
112actin filament depolymerization (GO:0030042)2.59609398
113nitrogen cycle metabolic process (GO:0071941)2.59560241
114extracellular fibril organization (GO:0043206)2.59070152
115one-carbon metabolic process (GO:0006730)2.58972013
116regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.58950354
117venous blood vessel morphogenesis (GO:0048845)2.58850318
118blood vessel endothelial cell migration (GO:0043534)2.56964147
119T cell apoptotic process (GO:0070231)2.56854637
120adherens junction assembly (GO:0034333)2.56205031
121negative regulation of catenin import into nucleus (GO:0035414)2.54483699
122wound healing, spreading of epidermal cells (GO:0035313)2.53276776
123regulation of extracellular matrix disassembly (GO:0010715)2.52777295
124cellular response to unfolded protein (GO:0034620)2.52703992
125heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.52143567
126negative regulation of chondrocyte differentiation (GO:0032331)2.51790121
127glyoxylate metabolic process (GO:0046487)2.51778461
128collagen catabolic process (GO:0030574)2.51441336
129glial cell migration (GO:0008347)2.51422821
130positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.50743020
131Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.50709889
132tooth mineralization (GO:0034505)2.50375253
133intracellular estrogen receptor signaling pathway (GO:0030520)2.49827522
134cortical actin cytoskeleton organization (GO:0030866)2.49779934
135negative regulation of erythrocyte differentiation (GO:0045647)2.49486743
136L-serine metabolic process (GO:0006563)2.49292909
137pinocytosis (GO:0006907)2.49237183
138heterochromatin organization (GO:0070828)2.49135590
139establishment of apical/basal cell polarity (GO:0035089)2.48553408
140positive regulation of fatty acid oxidation (GO:0046321)2.48409691
141regulation of glucose import in response to insulin stimulus (GO:2001273)2.48334055
142fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.47513558
143Arp2/3 complex-mediated actin nucleation (GO:0034314)2.47414047
144viral transcription (GO:0019083)2.47199661
145regulation of triglyceride biosynthetic process (GO:0010866)2.47162614
146response to laminar fluid shear stress (GO:0034616)2.46511657
147tricarboxylic acid metabolic process (GO:0072350)2.46105881
148protein hydroxylation (GO:0018126)2.44476954
149embryo implantation (GO:0007566)2.43646626
150aspartate family amino acid catabolic process (GO:0009068)2.43497825
151cochlea morphogenesis (GO:0090103)2.43394198
152multicellular organismal macromolecule metabolic process (GO:0044259)2.43107376
153fibril organization (GO:0097435)2.42186878
154ER-nucleus signaling pathway (GO:0006984)2.42123031
155regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.42066254
156cell-substrate adherens junction assembly (GO:0007045)2.41914309
157focal adhesion assembly (GO:0048041)2.41914309
158regulation of apoptotic process involved in morphogenesis (GO:1902337)2.41855716
159valine metabolic process (GO:0006573)2.41621808
160extracellular matrix disassembly (GO:0022617)2.41416354
161pteridine-containing compound biosynthetic process (GO:0042559)2.41323615
162convergent extension (GO:0060026)2.41237754
163activation of Rac GTPase activity (GO:0032863)2.41133297
164adherens junction organization (GO:0034332)2.41061138
165wound healing, spreading of cells (GO:0044319)2.40842970
166basement membrane organization (GO:0071711)2.40794824
167negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.40553318
168oxaloacetate metabolic process (GO:0006107)2.40035908
169kynurenine metabolic process (GO:0070189)2.39885669
170translational termination (GO:0006415)2.39802568
171positive regulation of endothelial cell apoptotic process (GO:2000353)2.38964045
172hyaluronan catabolic process (GO:0030214)2.35578706
173positive regulation of osteoblast proliferation (GO:0033690)2.35361746
174positive regulation of axon extension (GO:0045773)2.34333793
175regulation of establishment of planar polarity (GO:0090175)2.34089339
176bone trabecula formation (GO:0060346)2.32909734
177cellular response to nutrient (GO:0031670)2.30550955
178positive regulation of transforming growth factor beta receptor signaling pathway (GO:0030511)2.30270242
179chondrocyte proliferation (GO:0035988)2.29948293
180regulation of NFAT protein import into nucleus (GO:0051532)2.28615179
181multicellular organismal catabolic process (GO:0044243)2.27967612

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.52702455
2MYC_22102868_ChIP-Seq_BL_Human3.16902061
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.95317879
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.81504971
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.61114106
6VDR_21846776_ChIP-Seq_THP-1_Human2.53194003
7PPARA_22158963_ChIP-Seq_LIVER_Mouse2.47192642
8TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.43772970
9RXR_22158963_ChIP-Seq_LIVER_Mouse2.32838063
10TRIM28_21343339_ChIP-Seq_HEK293_Human2.30013324
11LXR_22292898_ChIP-Seq_THP-1_Human2.27647902
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.20347252
13* ELK3_25401928_ChIP-Seq_HUVEC_Human2.15269060
14ZNF263_19887448_ChIP-Seq_K562_Human1.97031710
15* KDM2B_26808549_Chip-Seq_DND41_Human1.96536934
16* TCF7_22412390_ChIP-Seq_EML_Mouse1.96000812
17KDM2B_26808549_Chip-Seq_SUP-B15_Human1.91683099
18FOXM1_23109430_ChIP-Seq_U2OS_Human1.89114599
19ESR2_21235772_ChIP-Seq_MCF-7_Human1.87954622
20* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.87131388
21RARG_19884340_ChIP-ChIP_MEFs_Mouse1.85035591
22E2F7_22180533_ChIP-Seq_HELA_Human1.83770641
23PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.82947859
24WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.74961419
25KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.74487796
26ERG_21242973_ChIP-ChIP_JURKAT_Human1.73155119
27RACK7_27058665_Chip-Seq_MCF-7_Human1.71762297
28MAF_26560356_Chip-Seq_TH1_Human1.70112424
29TP63_17297297_ChIP-ChIP_HaCaT_Human1.66815900
30* UTX_26944678_Chip-Seq_JUKART_Human1.59291132
31NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.56967711
32STAT3_1855785_ChIP-Seq_MESCs_Mouse1.54742216
33* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.53235469
34MYC_18555785_ChIP-Seq_MESCs_Mouse1.51993741
35ZFP281_18757296_ChIP-ChIP_E14_Mouse1.51391121
36LXR_22158963_ChIP-Seq_LIVER_Mouse1.50434065
37* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.49536614
38CLOCK_20551151_ChIP-Seq_293T_Human1.48990532
39* ATF3_27146783_Chip-Seq_COLON_Human1.48493897
40SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.47656927
41THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.41602428
42TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40695138
43STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.40385464
44P68_20966046_ChIP-Seq_HELA_Human1.39403159
45* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.38770295
46KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.38462010
47KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.35929031
48VDR_24763502_ChIP-Seq_THP-1_Human1.34559321
49STAT6_21828071_ChIP-Seq_BEAS2B_Human1.34340248
50ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.34140867
51POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.33274889
52MAF_26560356_Chip-Seq_TH2_Human1.32960606
53MYC_19079543_ChIP-ChIP_MESCs_Mouse1.31321941
54ELF1_20517297_ChIP-Seq_JURKAT_Human1.29704192
55RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.29325840
56BRD4_27068464_Chip-Seq_AML-cells_Mouse1.29072949
57UBF1/2_26484160_Chip-Seq_HMECs_Human1.26711477
58XRN2_22483619_ChIP-Seq_HELA_Human1.25950164
59NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.25711366
60SMC4_20622854_ChIP-Seq_HELA_Human1.24675618
61BCL6_27268052_Chip-Seq_Bcells_Human1.23827916
62EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.23821416
63SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.23717036
64TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.23676275
65RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.22522128
66KLF4_18555785_ChIP-Seq_MESCs_Mouse1.22300139
67DNAJC2_21179169_ChIP-ChIP_NT2_Human1.21580452
68EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.21135670
69CTCF_27219007_Chip-Seq_Bcells_Human1.19676424
70* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.19628014
71KDM2B_26808549_Chip-Seq_JURKAT_Human1.19493135
72* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.19075490
73BCOR_27268052_Chip-Seq_Bcells_Human1.19038716
74TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.18926241
75CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.18110857
76SMC1_22415368_ChIP-Seq_MEFs_Mouse1.17877319
77SA1_27219007_Chip-Seq_ERYTHROID_Human1.17620437
78* SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.17425694
79SMC3_22415368_ChIP-Seq_MEFs_Mouse1.17129272
80NCOR1_26117541_ChIP-Seq_K562_Human1.17077684
81* TET1_21451524_ChIP-Seq_MESCs_Mouse1.16601770
82ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.16064156
83* CREB1_26743006_Chip-Seq_LNCaP_Human1.15006069
84CTCF_27219007_Chip-Seq_ERYTHROID_Human1.14514823
85UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.14443176
86TET1_21490601_ChIP-Seq_MESCs_Mouse1.14148774
87TP53_22127205_ChIP-Seq_IMR90_Human1.13058172
88TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.13038942
89* SRY_22984422_ChIP-ChIP_TESTIS_Rat1.12298580
90* RUNX1_22412390_ChIP-Seq_EML_Mouse1.10939342
91ZFP281_27345836_Chip-Seq_ESCs_Mouse1.10573468
92CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.10154288
93SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.09539738
94FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.09477761
95CTCF_21964334_Chip-Seq_Bcells_Human1.09302623
96CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.08860516
97TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.08860420
98CIITA_25753668_ChIP-Seq_RAJI_Human1.08615403
99TBX20_22080862_ChIP-Seq_HEART_Mouse1.08447137
100TBX20_22328084_ChIP-Seq_HEART_Mouse1.08447137
101* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.08421969
102* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.07623057
103* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.07547775
104GATA1_22383799_ChIP-Seq_G1ME_Mouse1.07539894
105CTCF_21964334_ChIP-Seq_BJAB-B_Human1.07410627
106HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.07013250
107TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05607221
108CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.03983728
109SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.02845408
110P63_26484246_Chip-Seq_KERATINOCYTES_Human1.02623233
111ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.01832029
112TP53_23651856_ChIP-Seq_MEFs_Mouse1.01398828
113* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.01284742
114PHF8_20622854_ChIP-Seq_HELA_Human1.00828389
115CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.00677371
116SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.98748945
117KDM2B_26808549_Chip-Seq_K562_Human0.98699322
118IRF8_22096565_ChIP-ChIP_GC-B_Human0.98254482
119NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.97769854
120* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.97343321
121HIF1A_21447827_ChIP-Seq_MCF-7_Human0.96840930
122OCT4_18692474_ChIP-Seq_MEFs_Mouse0.96331221
123ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.95457175
124TP53_20018659_ChIP-ChIP_R1E_Mouse0.95299034
125MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.95078176
126ZFX_18555785_ChIP-Seq_MESCs_Mouse0.94629497
127MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.94433937
128ESR1_15608294_ChIP-ChIP_MCF-7_Human0.94096970
129NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.93864674
130SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.93756684
131* FOXP1_21924763_ChIP-Seq_HESCs_Human0.93580557
132CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.93335593
133MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.93168652
134* NFIB_24661679_ChIP-Seq_LUNG_Mouse0.93015882
135TP63_22573176_ChIP-Seq_HFKS_Human0.92934358
136RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.92276226
137* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91421475
138SOX9_24532713_ChIP-Seq_HFSC_Mouse0.91312194

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.92876628
2MP0009840_abnormal_foam_cell3.53049528
3MP0004272_abnormal_basement_membrane3.22268866
4MP0005360_urolithiasis3.02522482
5MP0002139_abnormal_hepatobiliary_system2.99428663
6MP0000751_myopathy2.87742766
7MP0005083_abnormal_biliary_tract2.76173559
8MP0005257_abnormal_intraocular_pressure2.71960622
9MP0001958_emphysema2.49869474
10MP0005451_abnormal_body_composition2.40825539
11MP0005076_abnormal_cell_differentiation2.39180771
12MP0005365_abnormal_bile_salt2.33535891
13MP0010352_gastrointestinal_tract_polyps2.30313252
14MP0003806_abnormal_nucleotide_metabolis2.28829679
15MP0010368_abnormal_lymphatic_system2.22793813
16MP0003303_peritoneal_inflammation2.22679174
17MP0002877_abnormal_melanocyte_morpholog2.18468373
18MP0003191_abnormal_cellular_cholesterol2.18143600
19MP0005085_abnormal_gallbladder_physiolo2.15802591
20MP0010030_abnormal_orbit_morphology2.12326069
21MP0003300_gastrointestinal_ulcer2.11021984
22MP0010234_abnormal_vibrissa_follicle2.04738244
23MP0005275_abnormal_skin_tensile1.96712949
24MP0003566_abnormal_cell_adhesion1.95613723
25MP0003252_abnormal_bile_duct1.79096003
26MP0000767_abnormal_smooth_muscle1.76645032
27MP0000685_abnormal_immune_system1.75029843
28MP0009384_cardiac_valve_regurgitation1.68874551
29MP0008260_abnormal_autophagy1.68293253
30MP0008438_abnormal_cutaneous_collagen1.65086926
31MP0005023_abnormal_wound_healing1.62404898
32MP0000013_abnormal_adipose_tissue1.59128958
33MP0010329_abnormal_lipoprotein_level1.56372437
34MP0005503_abnormal_tendon_morphology1.56187775
35MP0002060_abnormal_skin_morphology1.52189477
36MP0000759_abnormal_skeletal_muscle1.50497522
37MP0000609_abnormal_liver_physiology1.48222968
38MP0000749_muscle_degeneration1.46252155
39MP0001542_abnormal_bone_strength1.41852289
40MP0008961_abnormal_basal_metabolism1.41723300
41MP0001849_ear_inflammation1.40260557
42MP0005409_darkened_coat_color1.36767619
43MP0009278_abnormal_bone_marrow1.35599015
44MP0000733_abnormal_muscle_development1.34124982
45MP0010307_abnormal_tumor_latency1.29319469
46MP0001666_abnormal_nutrient_absorption1.29214100
47MP0005508_abnormal_skeleton_morphology1.26754961
48MP0003283_abnormal_digestive_organ1.25872355
49MP0002254_reproductive_system_inflammat1.25414747
50MP0004947_skin_inflammation1.22599476
51MP0002269_muscular_atrophy1.22035192
52MP0003656_abnormal_erythrocyte_physiolo1.21470608
53MP0002653_abnormal_ependyma_morphology1.21117873
54MP0005058_abnormal_lysosome_morphology1.21055554
55MP0005319_abnormal_enzyme/_coenzyme1.19649403
56MP0001730_embryonic_growth_arrest1.19380312
57MP0002896_abnormal_bone_mineralization1.19313600
58MP0008875_abnormal_xenobiotic_pharmacok1.19029808
59MP0004185_abnormal_adipocyte_glucose1.18482581
60MP0004510_myositis1.17595800
61MP0000678_abnormal_parathyroid_gland1.16765015
62MP0002796_impaired_skin_barrier1.15403230
63MP0003941_abnormal_skin_development1.14868911
64MP0000750_abnormal_muscle_regeneration1.13877200
65MP0000858_altered_metastatic_potential1.13446784
66MP0000598_abnormal_liver_morphology1.12919722
67MP0003436_decreased_susceptibility_to1.10970817
68MP0001348_abnormal_lacrimal_gland1.10195581
69MP0005501_abnormal_skin_physiology1.10194129
70MP0009053_abnormal_anal_canal1.09775542
71MP0004130_abnormal_muscle_cell1.09770398
72MP0000762_abnormal_tongue_morphology1.09526823
73MP0000537_abnormal_urethra_morphology1.08366325
74MP0005332_abnormal_amino_acid1.06838027
75MP0006138_congestive_heart_failure1.05654086
76MP0003091_abnormal_cell_migration1.04601970
77MP0002249_abnormal_larynx_morphology1.04186938
78MP0009643_abnormal_urine_homeostasis1.01579481
79MP0005666_abnormal_adipose_tissue1.01544690
80MP0004087_abnormal_muscle_fiber1.01208511
81MP0005397_hematopoietic_system_phenotyp1.01127977
82MP0001545_abnormal_hematopoietic_system1.01127977
83MP0005595_abnormal_vascular_smooth0.99370734
84MP0003385_abnormal_body_wall0.99212968
85MP0004957_abnormal_blastocyst_morpholog0.98412358
86MP0003172_abnormal_lysosome_physiology0.97913219
87MP0005330_cardiomyopathy0.97689370
88MP0001915_intracranial_hemorrhage0.97027588
89MP0001879_abnormal_lymphatic_vessel0.96517606
90MP0001243_abnormal_dermal_layer0.95557585
91MP0004197_abnormal_fetal_growth/weight/0.95010730
92MP0003950_abnormal_plasma_membrane0.94390137
93MP0006054_spinal_hemorrhage0.93906751
94MP0003828_pulmonary_edema0.93887987
95MP0002089_abnormal_postnatal_growth/wei0.93494190
96MP0004233_abnormal_muscle_weight0.92852941
97MP0000604_amyloidosis0.92439674
98MP0005375_adipose_tissue_phenotype0.92283253
99MP0004858_abnormal_nervous_system0.91819617
100MP0000534_abnormal_ureter_morphology0.91753654
101MP0010155_abnormal_intestine_physiology0.91632898
102MP0000477_abnormal_intestine_morphology0.90756689
103MP0004036_abnormal_muscle_relaxation0.90618714
104MP0000747_muscle_weakness0.90499436
105MP0002080_prenatal_lethality0.90034603
106MP0000490_abnormal_crypts_of0.89688119
107MP0003329_amyloid_beta_deposits0.89512135
108MP0003693_abnormal_embryo_hatching0.88750014
109MP0002998_abnormal_bone_remodeling0.88579665
110MP0002118_abnormal_lipid_homeostasis0.87740132
111MP0010630_abnormal_cardiac_muscle0.87621979
112MP0003866_abnormal_defecation0.87359921
113MP0002108_abnormal_muscle_morphology0.87047879
114MP0004084_abnormal_cardiac_muscle0.86534320
115MP0002398_abnormal_bone_marrow0.86482857
116MP0005623_abnormal_meninges_morphology0.86381931
117MP0003453_abnormal_keratinocyte_physiol0.85068336
118MP0009333_abnormal_splenocyte_physiolog0.84375724
119MP0002722_abnormal_immune_system0.84174892
120MP0000343_altered_response_to0.83425905
121MP0005464_abnormal_platelet_physiology0.83205236
122MP0005390_skeleton_phenotype0.83012313
123MP0002086_abnormal_extraembryonic_tissu0.82961100
124MP0003763_abnormal_thymus_physiology0.82926781
125MP0000350_abnormal_cell_proliferation0.82611354
126MP0005165_increased_susceptibility_to0.82579796
127MP0002166_altered_tumor_susceptibility0.82416675
128MP0000689_abnormal_spleen_morphology0.82379077
129MP0001614_abnormal_blood_vessel0.82373885
130MP0002972_abnormal_cardiac_muscle0.82349506
131MP0002909_abnormal_adrenal_gland0.82028160
132MP0002295_abnormal_pulmonary_circulatio0.81722230
133MP0001299_abnormal_eye_distance/0.81490989
134MP0008770_decreased_survivor_rate0.80338639
135MP0002019_abnormal_tumor_incidence0.80117218
136MP0001873_stomach_inflammation0.79931798
137MP0002106_abnormal_muscle_physiology0.79025422
138MP0003221_abnormal_cardiomyocyte_apopto0.78915487
139MP0000703_abnormal_thymus_morphology0.78746312
140MP0000467_abnormal_esophagus_morphology0.78494359
141MP0002332_abnormal_exercise_endurance0.78316166
142MP0003111_abnormal_nucleus_morphology0.77975859
143MP0003279_aneurysm0.77123690
144MP0003634_abnormal_glial_cell0.76170973
145MP0003942_abnormal_urinary_system0.75958636
146MP0002088_abnormal_embryonic_growth/wei0.75749060
147MP0002138_abnormal_hepatobiliary_system0.75703811
148MP0003984_embryonic_growth_retardation0.75577164
149MP0005584_abnormal_enzyme/coenzyme_acti0.75106847
150MP0009672_abnormal_birth_weight0.74985250
151MP0005621_abnormal_cell_physiology0.74892722
152MP0005620_abnormal_muscle_contractility0.74404363
153MP0000579_abnormal_nail_morphology0.73105037
154MP0000358_abnormal_cell_content/0.71877665
155MP0005369_muscle_phenotype0.71604993
156MP0008469_abnormal_protein_level0.71553976
157MP0002429_abnormal_blood_cell0.71348208
158MP0000003_abnormal_adipose_tissue0.71215288
159MP0004859_abnormal_synaptic_plasticity0.69507803
160MP0002128_abnormal_blood_circulation0.68774826

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)3.58986682
2Spinal rigidity (HP:0003306)3.40310344
3Abnormality of the Achilles tendon (HP:0005109)3.37759748
4Achilles tendon contracture (HP:0001771)3.31588102
5Distal lower limb muscle weakness (HP:0009053)3.31190684
6Deep venous thrombosis (HP:0002625)3.26312171
7Atrophic scars (HP:0001075)3.25021400
8Distal lower limb amyotrophy (HP:0008944)3.23028845
9Cerebral aneurysm (HP:0004944)3.22731379
10Hyperacusis (HP:0010780)3.19736072
11Fragile skin (HP:0001030)3.15921736
12Increased variability in muscle fiber diameter (HP:0003557)3.15163051
13Vertebral compression fractures (HP:0002953)3.09747572
14Xanthomatosis (HP:0000991)3.00966337
15Abnormality of monocarboxylic acid metabolism (HP:0010996)2.94392527
16Abnormality of skeletal muscle fiber size (HP:0012084)2.92616975
17Upper limb amyotrophy (HP:0009129)2.86747808
18Distal upper limb amyotrophy (HP:0007149)2.86747808
19Aortic dissection (HP:0002647)2.83625671
20Hand muscle atrophy (HP:0009130)2.65166951
21Vascular tortuosity (HP:0004948)2.62211139
22Centrally nucleated skeletal muscle fibers (HP:0003687)2.56447178
23Mitral regurgitation (HP:0001653)2.55949653
24Blue sclerae (HP:0000592)2.55188667
25Arterial tortuosity (HP:0005116)2.49737249
26Wormian bones (HP:0002645)2.49689375
27Lower limb amyotrophy (HP:0007210)2.49223557
28Round ear (HP:0100830)2.49170396
29Shallow orbits (HP:0000586)2.47464812
30Spastic diplegia (HP:0001264)2.46046464
31Abnormality of aromatic amino acid family metabolism (HP:0004338)2.45104266
32Long toe (HP:0010511)2.41886956
33Genu recurvatum (HP:0002816)2.39697103
34Abnormality of dentin (HP:0010299)2.39160453
35Short nail (HP:0001799)2.32539586
36Soft skin (HP:0000977)2.29324054
37Abnormality of the nasal mucosa (HP:0000433)2.28829919
38Aneurysm (HP:0002617)2.28587223
39Disproportionate tall stature (HP:0001519)2.26760364
40Abnormality of the lower motor neuron (HP:0002366)2.25484466
41Slender build (HP:0001533)2.24974925
42Pseudobulbar signs (HP:0002200)2.23615426
43Increased connective tissue (HP:0009025)2.23393532
44Nasal polyposis (HP:0100582)2.22800766
45Neonatal short-limb short stature (HP:0008921)2.21582786
46Mitral valve prolapse (HP:0001634)2.21494034
47Ankle contracture (HP:0006466)2.20939687
48Difficulty climbing stairs (HP:0003551)2.20198275
49Broad face (HP:0000283)2.19492714
50Adenoma sebaceum (HP:0009720)2.17387545
51Angiofibromas (HP:0010615)2.17387545
52Insomnia (HP:0100785)2.16272120
53Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.16129212
54Biconcave vertebral bodies (HP:0004586)2.14763872
55Reticulocytosis (HP:0001923)2.14728738
56Hyperammonemia (HP:0001987)2.13991953
57Long palpebral fissure (HP:0000637)2.11708345
58Myopathic facies (HP:0002058)2.11391465
59Back pain (HP:0003418)2.11158823
60Elbow flexion contracture (HP:0002987)2.11123944
61Thin bony cortex (HP:0002753)2.08829262
62Asymmetric septal hypertrophy (HP:0001670)2.08407252
63Hypobetalipoproteinemia (HP:0003563)2.07855328
64Radial bowing (HP:0002986)2.07477200
65Natal tooth (HP:0000695)2.05691573
66Ketosis (HP:0001946)2.03794435
67Muscle fiber inclusion bodies (HP:0100299)2.03788108
68Increased density of long bones (HP:0006392)2.02471469
69Polycythemia (HP:0001901)2.02085628
70Intrahepatic cholestasis (HP:0001406)2.00376505
71Hyperextensible skin (HP:0000974)1.99753504
72Stridor (HP:0010307)1.99683164
73Abnormality of glutamine family amino acid metabolism (HP:0010902)1.99458348
74Frequent falls (HP:0002359)1.98579624
75Obstructive sleep apnea (HP:0002870)1.98371432
76Bowing of the arm (HP:0006488)1.96996838
77Bowed forearm bones (HP:0003956)1.96996838
78Global brain atrophy (HP:0002283)1.96357741
79Premature rupture of membranes (HP:0001788)1.95955401
80Dilatation of the ascending aorta (HP:0005111)1.95825343
81Lymphangioma (HP:0100764)1.95453173
82Flat acetabular roof (HP:0003180)1.95248908
83Hypercortisolism (HP:0001578)1.94423178
84Joint laxity (HP:0001388)1.93345480
85Hyperlipoproteinemia (HP:0010980)1.93039270
86Nemaline bodies (HP:0003798)1.92848237
87Trismus (HP:0000211)1.91336694
88Hyporeflexia of lower limbs (HP:0002600)1.91112380
89Renovascular hypertension (HP:0100817)1.90907985
90Myoglobinuria (HP:0002913)1.89690742
91Elfin facies (HP:0004428)1.88615336
92Progressive muscle weakness (HP:0003323)1.88492252
93Late onset (HP:0003584)1.88424049
94Ulnar bowing (HP:0003031)1.88185120
95Ulnar deviation of the wrist (HP:0003049)1.87766694
96Deep palmar crease (HP:0006191)1.87728495
97Complement deficiency (HP:0004431)1.87699530
98Ependymoma (HP:0002888)1.85914896
99Cervical subluxation (HP:0003308)1.85468265
100Peritonitis (HP:0002586)1.85129084
101Scapular winging (HP:0003691)1.83338872
102Myocardial infarction (HP:0001658)1.81848480
103Type 1 muscle fiber predominance (HP:0003803)1.79933915
104Hypolipoproteinemia (HP:0010981)1.78597308
105Multiple enchondromatosis (HP:0005701)1.78118646
106Joint stiffness (HP:0001387)1.78032969
107Exercise-induced myalgia (HP:0003738)1.77392825
108Abnormality of complement system (HP:0005339)1.77266969
109Hypoalphalipoproteinemia (HP:0003233)1.77078368
110Muscle fiber splitting (HP:0003555)1.76932940
111Rhabdomyolysis (HP:0003201)1.76798409
112Cerebral inclusion bodies (HP:0100314)1.76526237
113Hypoventilation (HP:0002791)1.76519409
114Increased serum ferritin (HP:0003281)1.76302080
115Mildly elevated creatine phosphokinase (HP:0008180)1.76116368
116Abnormality of the calcaneus (HP:0008364)1.75814343
117Bowel diverticulosis (HP:0005222)1.75792931
118Follicular hyperkeratosis (HP:0007502)1.75607758
119Thin ribs (HP:0000883)1.74959469
120Spondylolisthesis (HP:0003302)1.74171695
121Aortic regurgitation (HP:0001659)1.73423788
122Renal duplication (HP:0000075)1.72919209
123Neonatal onset (HP:0003623)1.72161006
124Nuclear cataract (HP:0100018)1.71874916
125Wrist flexion contracture (HP:0001239)1.71631404
126Osteolytic defects of the phalanges of the hand (HP:0009771)1.70829268
127Osteolytic defects of the hand bones (HP:0009699)1.70829268
128Abnormality of the acetabulum (HP:0003170)1.70208876
129Polygenic inheritance (HP:0010982)1.69904280
130Striae distensae (HP:0001065)1.69577598
131Bladder diverticulum (HP:0000015)1.69406536
132Ventricular tachycardia (HP:0004756)1.68738355
133Axonal loss (HP:0003447)1.68680101
134Interstitial pulmonary disease (HP:0006530)1.67900493
135Nonimmune hydrops fetalis (HP:0001790)1.67631727
136Abnormal platelet function (HP:0011869)1.67240360
137Impaired platelet aggregation (HP:0003540)1.67240360
138Limb-girdle muscle atrophy (HP:0003797)1.67114370
139Abnormal neuron morphology (HP:0012757)1.66744049
140Abnormality of the motor neurons (HP:0002450)1.66744049
141Hyperparathyroidism (HP:0000843)1.66653157
142Neurofibrillary tangles (HP:0002185)1.66141475
143Thrombocytosis (HP:0001894)1.65568284
144Abnormal cartilage morphology (HP:0002763)1.65493114
145Esophageal varix (HP:0002040)1.65060481
146Cholelithiasis (HP:0001081)1.64667555
147Papilloma (HP:0012740)1.64527395
148Verrucae (HP:0200043)1.64527395
149Gastrointestinal inflammation (HP:0004386)1.64383589
150Basal cell carcinoma (HP:0002671)1.63153512
151Turricephaly (HP:0000262)1.62773231
152Ectopia lentis (HP:0001083)1.62662092
153Fibroma (HP:0010614)1.60917682
154Selective tooth agenesis (HP:0001592)1.60687319
155Congenital glaucoma (HP:0001087)1.60294350
156Severe short stature (HP:0003510)1.60175657
157Abnormality of the tricuspid valve (HP:0001702)1.59593947
158Coxa vara (HP:0002812)1.59536975
159Broad metatarsal (HP:0001783)1.58886182
160Aortic aneurysm (HP:0004942)1.58759898
161Generalized amyotrophy (HP:0003700)1.58613937
162Abnormality of sulfur amino acid metabolism (HP:0004339)1.58441198
163Abnormality of iron homeostasis (HP:0011031)1.57572460
164Recurrent bronchitis (HP:0002837)1.55926630

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.89491572
2PKN24.00746212
3ERN13.96567096
4EEF2K3.36098366
5MAP3K103.12780769
6SMG12.66336875
7PRPF4B2.26644790
8IRAK32.22774700
9MAP4K12.21118438
10SIK12.13182736
11TESK22.04717682
12BCKDK2.03103694
13SCYL22.01563801
14TTN1.97401849
15ICK1.91709931
16LRRK21.89251492
17PTK61.83069724
18RIPK11.78070103
19NTRK11.77546392
20ARAF1.76849111
21MYLK1.74087534
22TAOK21.59871900
23FLT31.59157638
24FGFR41.58145353
25TLK11.56213002
26KDR1.52394423
27EPHA21.49583236
28CDK121.43250519
29TESK11.42023344
30PDGFRA1.41454313
31NEK11.38744698
32MOS1.27306137
33CDC42BPA1.26967817
34TBK11.26657070
35PAK41.26625802
36PRKD21.25503658
37ALK1.22064942
38KSR21.21856354
39NEK21.21464135
40MAP3K31.19435874
41MAP3K111.18470231
42NME21.17576440
43TAOK11.17278324
44ZAP701.14045433
45BMX1.13545934
46GRK61.12910481
47STK101.12008189
48MTOR1.06647282
49MAP3K81.02654253
50BRAF1.02188079
51MAP2K21.01774081
52MAPKAPK30.97415194
53MAP3K70.95563966
54BUB10.93402383
55ILK0.93301934
56TYK20.93141615
57RPS6KB20.92775744
58MAP3K60.92466523
59MAP2K30.89825461
60PTK20.89776645
61PAK20.88688482
62BLK0.85561024
63MAP3K130.85480466
64DYRK1B0.83662631
65MET0.83359792
66JAK30.78536534
67ABL20.77609205
68DDR20.77265979
69MAPK110.77258891
70CDK40.74318978
71STK380.73742103
72DMPK0.72307927
73TIE10.72023310
74LMTK20.70334732
75MST1R0.69551954
76PRKD30.68989331
77CAMKK10.68193751
78RET0.67839751
79EPHB10.67678489
80RPS6KA40.65531477
81ROCK20.65098635
82LATS20.64342065
83JAK20.62576746
84PRKG20.62558168
85NEK90.60348826
86CSF1R0.56640844
87LIMK10.56550859
88BTK0.55856722
89CSK0.55025515
90PAK60.54262085
91AKT20.53470206
92HCK0.52497930
93TYRO30.52476003
94MAPK120.49905614
95EPHB20.49439300
96TGFBR20.48346318
97MAP3K10.47629540
98PAK10.47015515
99CAMK2G0.46433731
100JAK10.46304628
101CAMK1D0.45147985
102PIM10.44553622
103HIPK20.43874399
104RPS6KA10.43010803
105TGFBR10.41192286
106MARK20.40500650
107ERBB40.39438175
108MAP2K10.39210606
109CDK11A0.38464975
110MAPK70.36872811
111CDK60.36639620
112CDK70.35834193
113* DAPK30.35786602
114* ROCK10.35683844
115PRKD10.35366324
116MAP3K90.34973424
117CDK150.34784227
118SIK20.34609074
119PDGFRB0.33689822
120MAPK40.33395523
121PIM20.32251193
122PDPK10.32183195
123TRPM70.32165942
124PDK10.29793196
125AURKA0.29331243
126MAPKAPK20.29197526
127RPS6KL10.28773031
128RPS6KC10.28773031
129CDK180.28101702
130CDK140.28027981
131RPS6KA60.27837957
132RPS6KA20.26584476
133PRKCI0.25877384
134IKBKE0.25854304
135FGFR10.25620053

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.23498074
2Sulfur relay system_Homo sapiens_hsa041223.22250165
3Nitrogen metabolism_Homo sapiens_hsa009103.15251964
4Arginine biosynthesis_Homo sapiens_hsa002202.36316298
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.35264956
6Other glycan degradation_Homo sapiens_hsa005112.18905442
7ECM-receptor interaction_Homo sapiens_hsa045122.13552199
8Primary bile acid biosynthesis_Homo sapiens_hsa001202.08648819
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.08381000
10Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.05495528
11Biosynthesis of amino acids_Homo sapiens_hsa012302.01972263
12Fatty acid degradation_Homo sapiens_hsa000711.87538678
13Dilated cardiomyopathy_Homo sapiens_hsa054141.86550720
14One carbon pool by folate_Homo sapiens_hsa006701.81334044
15Glycosaminoglycan degradation_Homo sapiens_hsa005311.79377200
16Carbon metabolism_Homo sapiens_hsa012001.74591910
17Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.69970066
18Pentose phosphate pathway_Homo sapiens_hsa000301.68948991
19Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.68832055
20Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.66409684
21Selenocompound metabolism_Homo sapiens_hsa004501.65933800
22Cyanoamino acid metabolism_Homo sapiens_hsa004601.65299696
23Chronic myeloid leukemia_Homo sapiens_hsa052201.41183997
24Tryptophan metabolism_Homo sapiens_hsa003801.40840973
25Central carbon metabolism in cancer_Homo sapiens_hsa052301.38124503
26Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.36009513
27Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.29871512
28Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.29434118
29* Bladder cancer_Homo sapiens_hsa052191.28981691
30Fat digestion and absorption_Homo sapiens_hsa049751.27020214
31Adherens junction_Homo sapiens_hsa045201.23779559
32Vibrio cholerae infection_Homo sapiens_hsa051101.20457633
33Bile secretion_Homo sapiens_hsa049761.19731528
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.19586681
35Acute myeloid leukemia_Homo sapiens_hsa052211.18613532
36Regulation of actin cytoskeleton_Homo sapiens_hsa048101.18197398
37PPAR signaling pathway_Homo sapiens_hsa033201.18035120
38Lysine degradation_Homo sapiens_hsa003101.16542726
39Caffeine metabolism_Homo sapiens_hsa002321.15632964
40Salmonella infection_Homo sapiens_hsa051321.14322454
41Renal cell carcinoma_Homo sapiens_hsa052111.12667749
42Thyroid hormone signaling pathway_Homo sapiens_hsa049191.12299299
43Galactose metabolism_Homo sapiens_hsa000521.11441714
44Folate biosynthesis_Homo sapiens_hsa007901.11273065
45Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.11105847
46Antigen processing and presentation_Homo sapiens_hsa046121.10755976
47Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.08364314
48Fatty acid metabolism_Homo sapiens_hsa012121.06576966
49Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.05187901
50Lysosome_Homo sapiens_hsa041421.05079861
51VEGF signaling pathway_Homo sapiens_hsa043701.04856643
52B cell receptor signaling pathway_Homo sapiens_hsa046621.03326885
53GnRH signaling pathway_Homo sapiens_hsa049121.03232839
54Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.03066690
55Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.02592635
56Thyroid cancer_Homo sapiens_hsa052161.01653607
57ErbB signaling pathway_Homo sapiens_hsa040121.00054192
58Insulin resistance_Homo sapiens_hsa049310.99928589
59Phospholipase D signaling pathway_Homo sapiens_hsa040720.99243738
60Non-small cell lung cancer_Homo sapiens_hsa052230.99236298
61Cysteine and methionine metabolism_Homo sapiens_hsa002700.98751691
62Endocytosis_Homo sapiens_hsa041440.98252473
63mTOR signaling pathway_Homo sapiens_hsa041500.97566825
64Pyruvate metabolism_Homo sapiens_hsa006200.97013936
65Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.96629305
66Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.94282547
67MicroRNAs in cancer_Homo sapiens_hsa052060.94085707
68Complement and coagulation cascades_Homo sapiens_hsa046100.93690260
69Fructose and mannose metabolism_Homo sapiens_hsa000510.92509919
70Adipocytokine signaling pathway_Homo sapiens_hsa049200.92304681
71Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.91730496
72Tight junction_Homo sapiens_hsa045300.90344113
73Notch signaling pathway_Homo sapiens_hsa043300.89621590
74Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.88630364
75Drug metabolism - other enzymes_Homo sapiens_hsa009830.88463660
76Axon guidance_Homo sapiens_hsa043600.88149516
77Hippo signaling pathway_Homo sapiens_hsa043900.85286633
78Insulin signaling pathway_Homo sapiens_hsa049100.83082131
79Pentose and glucuronate interconversions_Homo sapiens_hsa000400.81480175
80TNF signaling pathway_Homo sapiens_hsa046680.81390485
81Estrogen signaling pathway_Homo sapiens_hsa049150.81233185
82Melanogenesis_Homo sapiens_hsa049160.81098029
83Protein digestion and absorption_Homo sapiens_hsa049740.80642543
84Rap1 signaling pathway_Homo sapiens_hsa040150.78644583
85Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.78438617
86Primary immunodeficiency_Homo sapiens_hsa053400.77932836
87Gap junction_Homo sapiens_hsa045400.76011415
88Neurotrophin signaling pathway_Homo sapiens_hsa047220.75453528
89PI3K-Akt signaling pathway_Homo sapiens_hsa041510.74188087
90Small cell lung cancer_Homo sapiens_hsa052220.72651387
91Proteoglycans in cancer_Homo sapiens_hsa052050.72362349
92Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.72222505
93Viral carcinogenesis_Homo sapiens_hsa052030.71625304
94DNA replication_Homo sapiens_hsa030300.70869577
95Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.70716933
96Apoptosis_Homo sapiens_hsa042100.70680352
97Prion diseases_Homo sapiens_hsa050200.70417098
98Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.69612044
99Sphingolipid signaling pathway_Homo sapiens_hsa040710.68692359
100Hepatitis C_Homo sapiens_hsa051600.67988954
101Prostate cancer_Homo sapiens_hsa052150.67808255
102* Pathways in cancer_Homo sapiens_hsa052000.67444888
103Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.66527698
104MAPK signaling pathway_Homo sapiens_hsa040100.65976616
105Toll-like receptor signaling pathway_Homo sapiens_hsa046200.65917523
106AMPK signaling pathway_Homo sapiens_hsa041520.65805448
107Basal cell carcinoma_Homo sapiens_hsa052170.65774090
108Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.65610432
109Staphylococcus aureus infection_Homo sapiens_hsa051500.65578321
110Melanoma_Homo sapiens_hsa052180.64874919
111Viral myocarditis_Homo sapiens_hsa054160.64561914
112Malaria_Homo sapiens_hsa051440.63726743
113Hepatitis B_Homo sapiens_hsa051610.63702092
114Pancreatic cancer_Homo sapiens_hsa052120.63364104
115Focal adhesion_Homo sapiens_hsa045100.63325488
116Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.63322462
117Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.61762099
118Starch and sucrose metabolism_Homo sapiens_hsa005000.61326356
119Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.61078250
120Leukocyte transendothelial migration_Homo sapiens_hsa046700.60715782
121Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.60218657
122Glioma_Homo sapiens_hsa052140.59799055
123AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.58603349
124HTLV-I infection_Homo sapiens_hsa051660.58394306
125Shigellosis_Homo sapiens_hsa051310.56827597
126Colorectal cancer_Homo sapiens_hsa052100.56162220
127beta-Alanine metabolism_Homo sapiens_hsa004100.55968812
128Butanoate metabolism_Homo sapiens_hsa006500.55563132
129HIF-1 signaling pathway_Homo sapiens_hsa040660.54390690
130Synaptic vesicle cycle_Homo sapiens_hsa047210.54380769
131Endometrial cancer_Homo sapiens_hsa052130.53370195
132Longevity regulating pathway - mammal_Homo sapiens_hsa042110.52395594
133Choline metabolism in cancer_Homo sapiens_hsa052310.52166993
134Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.51935419
135Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.51805463
136Toxoplasmosis_Homo sapiens_hsa051450.51750282
137Amoebiasis_Homo sapiens_hsa051460.51680166
138Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.50951545
139Propanoate metabolism_Homo sapiens_hsa006400.48835717
140Osteoclast differentiation_Homo sapiens_hsa043800.45533399
141Glucagon signaling pathway_Homo sapiens_hsa049220.44680736
142Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.43223179
143Arginine and proline metabolism_Homo sapiens_hsa003300.42311277
144Systemic lupus erythematosus_Homo sapiens_hsa053220.40463412
145Carbohydrate digestion and absorption_Homo sapiens_hsa049730.40299627
146ABC transporters_Homo sapiens_hsa020100.39940926
147Phenylalanine metabolism_Homo sapiens_hsa003600.39684714
148Prolactin signaling pathway_Homo sapiens_hsa049170.39219617
149T cell receptor signaling pathway_Homo sapiens_hsa046600.38652689
150Leishmaniasis_Homo sapiens_hsa051400.38081235

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