DAPL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of protein sumoylation (GO:0033235)9.43426122
2protein K11-linked deubiquitination (GO:0035871)9.16547249
3negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)8.86550953
4negative regulation of T-helper cell differentiation (GO:0045623)8.86550953
5seminiferous tubule development (GO:0072520)8.44119319
6sphingoid metabolic process (GO:0046519)7.97519814
7regulation of T-helper 1 cell differentiation (GO:0045625)7.83098251
8keratinocyte proliferation (GO:0043616)7.79030829
9righting reflex (GO:0060013)7.70039065
10negative regulation of type 2 immune response (GO:0002829)7.55843502
11activation of protein kinase A activity (GO:0034199)7.48010380
12detection of chemical stimulus involved in sensory perception (GO:0050907)7.46442846
13keratinization (GO:0031424)7.37875146
14positive regulation of RNA splicing (GO:0033120)7.18372128
15multicellular organismal water homeostasis (GO:0050891)7.11629111
16regulation of T-helper 2 cell differentiation (GO:0045628)6.96732044
17negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)6.93292766
18cAMP biosynthetic process (GO:0006171)6.77589511
19negative regulation of alpha-beta T cell differentiation (GO:0046639)6.67052565
20enteric nervous system development (GO:0048484)6.57445401
21glucosamine-containing compound catabolic process (GO:1901072)6.53621339
22dendritic spine morphogenesis (GO:0060997)6.53129410
23regulation of cell proliferation involved in kidney development (GO:1901722)6.42140755
24positive regulation of mitochondrial fission (GO:0090141)6.41682180
25sphingosine metabolic process (GO:0006670)6.39373080
26keratinocyte differentiation (GO:0030216)6.35733113
27regulation of phospholipase A2 activity (GO:0032429)6.25450062
28long-chain fatty acid biosynthetic process (GO:0042759)6.21183470
29positive regulation of interleukin-8 secretion (GO:2000484)6.02168383
30water homeostasis (GO:0030104)5.92171995
31viral transcription (GO:0019083)5.88514782
32regulation of protein sumoylation (GO:0033233)5.88065366
33diol metabolic process (GO:0034311)5.87487148
34arachidonic acid secretion (GO:0050482)5.87049821
35icosanoid secretion (GO:0032309)5.87049821
36heterotypic cell-cell adhesion (GO:0034113)5.85637628
37synaptic transmission, dopaminergic (GO:0001963)5.76106198
38regulation of ruffle assembly (GO:1900027)5.58185432
39translational termination (GO:0006415)5.53386378
40positive regulation of T-helper 1 type immune response (GO:0002827)5.40156691
41detection of chemical stimulus (GO:0009593)5.38184654
42interferon-gamma secretion (GO:0072643)5.30684342
43regulation of chemokine secretion (GO:0090196)5.30379550
44regulation of transforming growth factor beta1 production (GO:0032908)5.26270804
45ribosomal small subunit biogenesis (GO:0042274)5.17530774
46epidermal cell differentiation (GO:0009913)5.10039706
47neurofilament cytoskeleton organization (GO:0060052)4.99794405
48bundle of His cell to Purkinje myocyte communication (GO:0086069)4.91347529
49cilium or flagellum-dependent cell motility (GO:0001539)4.90067876
50positive regulation of glomerulus development (GO:0090193)4.83624014
51endothelial cell differentiation (GO:0045446)4.83461243
52nephron epithelium morphogenesis (GO:0072088)4.80212130
53nephron tubule morphogenesis (GO:0072078)4.80212130
54drug transmembrane transport (GO:0006855)4.75383990
55icosanoid transport (GO:0071715)4.74078385
56fatty acid derivative transport (GO:1901571)4.74078385
57regulation of interleukin-8 secretion (GO:2000482)4.70465437
58SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.70400572
59keratinocyte development (GO:0003334)4.67642536
60neuronal ion channel clustering (GO:0045161)4.64836717
61protein targeting to ER (GO:0045047)4.62949650
62G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.62616721
63cotranslational protein targeting to membrane (GO:0006613)4.60881005
64regulation of mitochondrial fission (GO:0090140)4.58891468
65cyclooxygenase pathway (GO:0019371)4.54745714
66positive regulation of chemokine secretion (GO:0090197)4.53032564
67linoleic acid metabolic process (GO:0043651)4.52900235
68epidermis development (GO:0008544)4.52320325
69fatty acid elongation (GO:0030497)4.52099329
70retina layer formation (GO:0010842)4.51260351
71establishment of protein localization to endoplasmic reticulum (GO:0072599)4.49987369
72regulation of hypersensitivity (GO:0002883)4.42051547
73viral life cycle (GO:0019058)4.41705948
74translational elongation (GO:0006414)4.37129623
75energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)4.36697842
76ATP hydrolysis coupled proton transport (GO:0015991)4.36697842
77protein localization to endoplasmic reticulum (GO:0070972)4.34582547
78reflex (GO:0060004)4.32292634
79neural tube formation (GO:0001841)4.28419714
80intermediate filament organization (GO:0045109)4.23739263
81prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060524.22006396
82lipoxygenase pathway (GO:0019372)4.21580736
83positive regulation of T-helper cell differentiation (GO:0045624)4.17867482
84cellular protein complex disassembly (GO:0043624)4.17584937
85negative regulation of cytosolic calcium ion concentration (GO:0051481)4.14996554
86peptide cross-linking (GO:0018149)4.08361510
87detection of bacterium (GO:0016045)4.08028868
88hepatocyte apoptotic process (GO:0097284)4.04824192
89ribosomal small subunit assembly (GO:0000028)4.03131747
90hair cycle (GO:0042633)3.94854357
91molting cycle (GO:0042303)3.94854357
92nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.94611030
93dendritic spine organization (GO:0097061)3.91672972
94embryonic digestive tract morphogenesis (GO:0048557)3.90980103
95regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.87775243
96maturation of SSU-rRNA (GO:0030490)3.84301571
97gland morphogenesis (GO:0022612)3.84280106
98regulation of T-helper 1 type immune response (GO:0002825)3.84105543
99positive regulation of membrane potential (GO:0045838)3.75011477
100negative regulation of actin filament bundle assembly (GO:0032232)3.74425463
101chemical homeostasis within a tissue (GO:0048875)3.73090995
102cellular response to ATP (GO:0071318)3.73078061
103cyclic purine nucleotide metabolic process (GO:0052652)3.71666099
104cardiolipin metabolic process (GO:0032048)3.68402069
105cyclic nucleotide biosynthetic process (GO:0009190)3.66046796
106negative regulation of T cell mediated immunity (GO:0002710)3.65370554
107negative regulation of interleukin-2 production (GO:0032703)3.63221145
108phospholipid scrambling (GO:0017121)3.60907437
109protein localization to synapse (GO:0035418)3.59770333
110energy coupled proton transport, down electrochemical gradient (GO:0015985)3.59288729
111ATP synthesis coupled proton transport (GO:0015986)3.59288729
112response to dietary excess (GO:0002021)3.58812032
113negative regulation of kidney development (GO:0090185)3.58708033
114negative regulation of stress fiber assembly (GO:0051497)3.57076598
115prostanoid biosynthetic process (GO:0046457)3.56960923
116prostaglandin biosynthetic process (GO:0001516)3.56960923
117negative regulation of alpha-beta T cell activation (GO:0046636)3.56027997
118regulation of glomerulus development (GO:0090192)3.55478264
119phosphatidylinositol acyl-chain remodeling (GO:0036149)3.54674698
120chaperone-mediated protein transport (GO:0072321)3.52662170
121phosphatidylcholine acyl-chain remodeling (GO:0036151)3.52263805
122vocalization behavior (GO:0071625)3.50570306
123hemidesmosome assembly (GO:0031581)3.47565122
124renal tubule morphogenesis (GO:0061333)3.46830780
125long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.45495055
126protein complex disassembly (GO:0043241)3.45245921
127negative regulation of acute inflammatory response (GO:0002674)3.44100109
128regulation of cAMP-mediated signaling (GO:0043949)3.40368192
129cAMP metabolic process (GO:0046058)3.40172520
130positive regulation of interleukin-4 production (GO:0032753)3.39086687
131detection of other organism (GO:0098543)3.36862141
132positive regulation of vesicle fusion (GO:0031340)3.35462169
133cardiac right ventricle morphogenesis (GO:0003215)3.34936286
134left/right axis specification (GO:0070986)3.33392170
135detection of light stimulus involved in visual perception (GO:0050908)3.31384285
136detection of light stimulus involved in sensory perception (GO:0050962)3.31384285
137positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)3.30915358
138negative regulation of keratinocyte proliferation (GO:0010839)3.29984102
139translational initiation (GO:0006413)3.27923272
140vitamin transmembrane transport (GO:0035461)3.27613622
141mitochondrial fusion (GO:0008053)3.27465458
142negative regulation of T cell differentiation (GO:0045581)3.27123461
143cellular response to glucagon stimulus (GO:0071377)3.25940614
144amino sugar catabolic process (GO:0046348)3.24976451
145protein targeting to membrane (GO:0006612)3.24296869
146monoamine transport (GO:0015844)3.24222831
147negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.23743823
148negative regulation of interferon-gamma production (GO:0032689)3.21847583
149negative regulation of astrocyte differentiation (GO:0048712)3.18952608
150macromolecular complex disassembly (GO:0032984)3.18094456
151positive regulation of steroid hormone secretion (GO:2000833)3.17473007
152positive regulation of protein targeting to membrane (GO:0090314)3.16517272
153leukotriene biosynthetic process (GO:0019370)3.14917616
154phosphatidylserine acyl-chain remodeling (GO:0036150)3.14342975
155drug transport (GO:0015893)3.13320583
156cellular zinc ion homeostasis (GO:0006882)3.12374071
157hyaluronan catabolic process (GO:0030214)3.10443318
158regulation of acute inflammatory response to antigenic stimulus (GO:0002864)3.10415853
159phosphatidylserine metabolic process (GO:0006658)3.08490346
160prostanoid metabolic process (GO:0006692)3.08291906
161prostaglandin metabolic process (GO:0006693)3.08291906
162T-helper cell differentiation (GO:0042093)3.03869890
163CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.03869890
164hindbrain development (GO:0030902)3.03843549
165water transport (GO:0006833)3.03049990
166regulation of T-helper cell differentiation (GO:0045622)3.02286921
167axonemal dynein complex assembly (GO:0070286)2.98483481
168negative regulation of lipase activity (GO:0060192)2.97935260
169potassium ion transmembrane transport (GO:0071805)2.96880352
170cellular potassium ion transport (GO:0071804)2.96880352
171sequestering of metal ion (GO:0051238)2.95195746
172ribosomal large subunit biogenesis (GO:0042273)2.94711844
173positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.94453866
174male meiosis (GO:0007140)2.91102582
175adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway (GO:0007193)2.91040514
176chemosensory behavior (GO:0007635)2.90697379
177phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.89667688
178unsaturated fatty acid biosynthetic process (GO:0006636)2.88074736
179positive regulation of hair cycle (GO:0042635)2.87357686
180positive regulation of hair follicle development (GO:0051798)2.87357686
181retinal metabolic process (GO:0042574)2.84502769
182positive regulation of mitochondrial membrane permeability (GO:0035794)2.84373633
183exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.82705244
184phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.82173599
185surfactant homeostasis (GO:0043129)2.80687335
186fatty-acyl-CoA metabolic process (GO:0035337)2.79959753
187sulfur amino acid catabolic process (GO:0000098)2.79510073
188inflammatory response to antigenic stimulus (GO:0002437)2.78304469
189sphingolipid biosynthetic process (GO:0030148)2.77711972
190desmosome organization (GO:0002934)13.0222943
191tooth mineralization (GO:0034505)11.8399686
192detection of chemical stimulus involved in sensory perception of smell (GO:0050911)11.6953606
193establishment of skin barrier (GO:0061436)11.0826381
194regulation of water loss via skin (GO:0033561)10.0561420

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse8.43566428
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse6.83143450
3IGF1R_20145208_ChIP-Seq_DFB_Human4.73440873
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.40825082
5P63_26484246_Chip-Seq_KERATINOCYTES_Human3.12188238
6SOX9_24532713_ChIP-Seq_HFSC_Mouse2.95094907
7SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.59653560
8ESR1_21235772_ChIP-Seq_MCF-7_Human2.48056674
9TRIM28_21343339_ChIP-Seq_HEK293_Human2.33123028
10PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.17818375
11STAT6_21828071_ChIP-Seq_BEAS2B_Human2.07810519
12ESR2_21235772_ChIP-Seq_MCF-7_Human2.07678148
13CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.06277759
14TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.03318535
15TP63_17297297_ChIP-ChIP_HaCaT_Human14.9919154
16PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.97085968
17TP53_16413492_ChIP-PET_HCT116_Human1.95959648
18ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.94702585
19EGR1_19374776_ChIP-ChIP_THP-1_Human1.92607646
20SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.90479855
21SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.90479855
22TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.90315942
23POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.90315942
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.84385951
25SRY_22984422_ChIP-ChIP_TESTIS_Rat1.73905124
26SOX2_20726797_ChIP-Seq_SW620_Human1.71074694
27* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.70815368
28* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.70401571
29CTBP1_25329375_ChIP-Seq_LNCAP_Human1.68774066
30* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.68652161
31FOXO3_23340844_ChIP-Seq_DLD1_Human1.68564819
32GBX2_23144817_ChIP-Seq_PC3_Human1.65743636
33TCF4_18268006_ChIP-ChIP_LS174T_Human1.64134059
34JARID2_20064375_ChIP-Seq_MESCs_Mouse1.56563042
35ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.54843978
36ZNF274_21170338_ChIP-Seq_K562_Hela1.52674882
37RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.52485742
38EGR1_23403033_ChIP-Seq_LIVER_Mouse1.47816665
39EZH2_22144423_ChIP-Seq_EOC_Human1.47738266
40FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.46657181
41BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.43442178
42STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.42006821
43* TP63_23658742_ChIP-Seq_EP156T_Human1.40222840
44SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.39854536
45TP53_18474530_ChIP-ChIP_U2OS_Human1.33666065
46CJUN_26792858_Chip-Seq_BT549_Human1.32170576
47CTBP2_25329375_ChIP-Seq_LNCAP_Human1.29328273
48RUNX1_27514584_Chip-Seq_MCF-7_Human1.27087164
49* SMAD3_21741376_ChIP-Seq_EPCs_Human1.25952953
50* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25859885
51* YY1_22570637_ChIP-Seq_MALME-3M_Human1.25535984
52GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.22050619
53* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.21120286
54MTF2_20144788_ChIP-Seq_MESCs_Mouse1.20121628
55UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20031438
56* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.19644903
57DROSHA_22980978_ChIP-Seq_HELA_Human1.18864128
58ER_23166858_ChIP-Seq_MCF-7_Human1.18202820
59* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.16516689
60* NANOG_18555785_Chip-Seq_ESCs_Mouse1.15068220
61REST_21632747_ChIP-Seq_MESCs_Mouse1.14178614
62STAT3_23295773_ChIP-Seq_U87_Human1.13924248
63TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.11245746
64TP63_22573176_ChIP-Seq_HFKS_Human1.10879214
65* AR_25329375_ChIP-Seq_VCAP_Human1.10841226
66BMI1_23680149_ChIP-Seq_NPCS_Mouse1.10048505
67EGR1_19032775_ChIP-ChIP_M12_Human1.09878380
68KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.09811837
69TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09708047
70KLF5_25053715_ChIP-Seq_YYC3_Human1.09554490
71PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.08066430
72SMAD4_21799915_ChIP-Seq_A2780_Human1.06934708
73GATA3_24758297_ChIP-Seq_MCF-7_Human1.06568090
74TBL1_22424771_ChIP-Seq_293T_Human1.06296020
75* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.06113186
76GATA1_19941826_ChIP-Seq_K562_Human1.05866659
77IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.05295335
78CBP_20019798_ChIP-Seq_JUKART_Human1.05295335
79FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04955469
80TP53_20018659_ChIP-ChIP_R1E_Mouse1.04685400
81GATA6_21074721_ChIP-Seq_CACO-2_Human1.04342460
82* GATA4_25053715_ChIP-Seq_YYC3_Human1.03318448
83KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.03174489
84EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.02459229
85SMAD4_21741376_ChIP-Seq_HESCs_Human1.02178031
86EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.01859392
87STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.01104316
88CDX2_20551321_ChIP-Seq_CACO-2_Human1.00344300
89BCAT_22108803_ChIP-Seq_LS180_Human0.99761045
90ZNF263_19887448_ChIP-Seq_K562_Human0.99326969
91ETV2_25802403_ChIP-Seq_MESCs_Mouse0.98743935
92CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.97495954
93EZH2_27294783_Chip-Seq_NPCs_Mouse0.96803503
94CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.96187587
95SUZ12_27294783_Chip-Seq_NPCs_Mouse0.96177042
96GATA1_22025678_ChIP-Seq_K562_Human0.95250287
97BP1_19119308_ChIP-ChIP_Hs578T_Human0.94444804
98FUS_26573619_Chip-Seq_HEK293_Human0.94244131
99NANOG_20526341_ChIP-Seq_ESCs_Human0.92526211
100ESR1_20079471_ChIP-ChIP_T-47D_Human0.91236938
101RING1B_27294783_Chip-Seq_ESCs_Mouse0.91040915
102RXR_22108803_ChIP-Seq_LS180_Human0.90842773
103ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.90442120
104* PRDM14_20953172_ChIP-Seq_ESCs_Human0.90431720
105HIF1A_21447827_ChIP-Seq_MCF-7_Human0.90228628
106CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89773084
107* TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.89422905
108EZH2_27304074_Chip-Seq_ESCs_Mouse0.89285731
109* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.89150474
110SUZ12_27294783_Chip-Seq_ESCs_Mouse0.89060240
111EZH2_18974828_ChIP-Seq_MESCs_Mouse0.88956163
112RNF2_18974828_ChIP-Seq_MESCs_Mouse0.88956163
113CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.88907622
114EED_16625203_ChIP-ChIP_MESCs_Mouse0.88502804
115REST_18959480_ChIP-ChIP_MESCs_Mouse0.88099703
116FOXM1_26456572_ChIP-Seq_MCF-7_Human0.87019096
117AHR_22903824_ChIP-Seq_MCF-7_Human0.86676154
118SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.85846401
119UBF1/2_26484160_Chip-Seq_HMECs_Human0.84076203
120VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.82931696
121* CEBPB_22108803_ChIP-Seq_LS180_Human0.82853861
122RBPJ_21746931_ChIP-Seq_IB4_Human0.82482655
123FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.82232042
124AR_21572438_ChIP-Seq_LNCaP_Human0.80735540
125SOX2_27498859_Chip-Seq_STOMACH_Mouse0.79463206
126KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.79183265
127ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.77956831
128FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.77930827
129* TCF4_22108803_ChIP-Seq_LS180_Human0.76628289
130EZH2_27294783_Chip-Seq_ESCs_Mouse0.76173207
131SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.75307975
132SA1_27219007_Chip-Seq_ERYTHROID_Human0.75083754
133RNF2_27304074_Chip-Seq_NSC_Mouse0.71957066
134HNFA_21074721_ChIP-Seq_CACO-2_Human0.71650641
135VDR_22108803_ChIP-Seq_LS180_Human0.70871864
136SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.69612884
137PPAR_26484153_Chip-Seq_NCI-H1993_Human0.69450865
138IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.69248525
139CBX2_22325352_ChIP-Seq_293T-Rex_Human0.68290073
140SA1_27219007_Chip-Seq_Bcells_Human0.67916304
141AUTS2_25519132_ChIP-Seq_293T-REX_Human0.67530916
142PHF8_20622853_ChIP-Seq_HELA_Human0.67051083
143SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.66138189
144BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.65712887
145* GATA6_25053715_ChIP-Seq_YYC3_Human0.65383266
146CBX2_27304074_Chip-Seq_ESCs_Mouse0.65016954
147JARID2_20075857_ChIP-Seq_MESCs_Mouse0.64669751
148RARG_19884340_ChIP-ChIP_MEFs_Mouse0.64016387
149JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.63825261
150RNF2_27304074_Chip-Seq_ESCs_Mouse0.63418400
151* FOXA1_27270436_Chip-Seq_PROSTATE_Human0.62762648
152* FOXA1_25329375_ChIP-Seq_VCAP_Human0.62762648
153GATA3_21867929_ChIP-Seq_TH1_Mouse0.62655095
154CTCF_27219007_Chip-Seq_Bcells_Human0.62632771
155STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.61844460
156RACK7_27058665_Chip-Seq_MCF-7_Human0.61229643
157SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.61082497
158PIAS1_25552417_ChIP-Seq_VCAP_Human0.60135101
159ARNT_22903824_ChIP-Seq_MCF-7_Human0.59371334
160SMAD3_21741376_ChIP-Seq_HESCs_Human0.59281180
161SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.59229137
162* P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.58751854
163ATF3_27146783_Chip-Seq_COLON_Human0.57204589
164ETV1_20927104_ChIP-Seq_GIST48_Human0.56850217
165HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.55847982
166ELK1_22589737_ChIP-Seq_MCF10A_Human0.55206459

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005084_abnormal_gallbladder_morpholo9.64270830
2MP0002796_impaired_skin_barrier7.47804824
3MP0008961_abnormal_basal_metabolism7.04427446
4MP0003941_abnormal_skin_development6.21621367
5MP0010234_abnormal_vibrissa_follicle5.50458335
6MP0004381_abnormal_hair_follicle5.49571536
7MP0005501_abnormal_skin_physiology4.61353787
8MP0005275_abnormal_skin_tensile3.77085705
9MP0005451_abnormal_body_composition3.57176606
10MP0004130_abnormal_muscle_cell3.38538240
11MP0002098_abnormal_vibrissa_morphology3.35272099
12MP0001216_abnormal_epidermal_layer3.22962835
13MP0002060_abnormal_skin_morphology3.17329416
14MP0005377_hearing/vestibular/ear_phenot2.94173985
15MP0003878_abnormal_ear_physiology2.94173985
16MP0003453_abnormal_keratinocyte_physiol2.90772549
17MP0000566_synostosis2.84980933
18MP0002254_reproductive_system_inflammat2.83833496
19MP0010771_integument_phenotype2.83029967
20MP0010678_abnormal_skin_adnexa2.70685244
21MP0002009_preneoplasia2.62756721
22MP0000383_abnormal_hair_follicle2.59221460
23MP0000579_abnormal_nail_morphology2.58564894
24MP0009379_abnormal_foot_pigmentation2.56072855
25MP0004133_heterotaxia2.44220819
26MP0003252_abnormal_bile_duct2.38648711
27MP0004947_skin_inflammation2.34831316
28MP0000647_abnormal_sebaceous_gland2.31143448
29MP0002928_abnormal_bile_duct2.28031687
30MP0000377_abnormal_hair_follicle2.24118927
31MP0001346_abnormal_lacrimal_gland2.22695223
32MP0004043_abnormal_pH_regulation2.13164529
33MP0004885_abnormal_endolymph2.04217069
34MP0000467_abnormal_esophagus_morphology1.97406160
35MP0000427_abnormal_hair_cycle1.95192095
36MP0005220_abnormal_exocrine_pancreas1.89177301
37MP0002751_abnormal_autonomic_nervous1.85132456
38MP0005448_abnormal_energy_balance1.85040090
39MP0005253_abnormal_eye_physiology1.70849704
40MP0005075_abnormal_melanosome_morpholog1.61646464
41MP0009931_abnormal_skin_appearance1.54965661
42MP0001191_abnormal_skin_condition1.54805193
43MP0000762_abnormal_tongue_morphology1.53577674
44MP0001270_distended_abdomen1.51790672
45MP0002909_abnormal_adrenal_gland1.51632672
46MP0003136_yellow_coat_color1.50716675
47MP0002877_abnormal_melanocyte_morpholog1.49832016
48MP0003943_abnormal_hepatobiliary_system1.43950595
49MP0005646_abnormal_pituitary_gland1.42275978
50MP0008995_early_reproductive_senescence1.38097977
51MP0001984_abnormal_olfaction1.36308399
52MP0003566_abnormal_cell_adhesion1.34224783
53MP0000367_abnormal_coat/_hair1.32295164
54MP0002876_abnormal_thyroid_physiology1.31864246
55MP0005551_abnormal_eye_electrophysiolog1.30758316
56MP0002102_abnormal_ear_morphology1.27728729
57MP0005171_absent_coat_pigmentation1.25556678
58MP0004782_abnormal_surfactant_physiolog1.24642248
59MP0008004_abnormal_stomach_pH1.18830534
60MP0001944_abnormal_pancreas_morphology1.18768625
61MP0000371_diluted_coat_color1.17887220
62MP0001243_abnormal_dermal_layer1.16231058
63MP0001501_abnormal_sleep_pattern1.15608083
64MP0000465_gastrointestinal_hemorrhage1.14727019
65MP0004185_abnormal_adipocyte_glucose1.13801055
66MP0002638_abnormal_pupillary_reflex1.13513380
67MP0001851_eye_inflammation1.11590531
68MP0004272_abnormal_basement_membrane1.08503595
69MP0001905_abnormal_dopamine_level1.07801931
70MP0001485_abnormal_pinna_reflex1.07080487
71MP0003191_abnormal_cellular_cholesterol1.05828843
72MP0010352_gastrointestinal_tract_polyps1.05644204
73MP0001340_abnormal_eyelid_morphology1.05454182
74MP0008875_abnormal_xenobiotic_pharmacok1.04830321
75MP0005257_abnormal_intraocular_pressure1.03170663
76MP0001502_abnormal_circadian_rhythm1.00101244
77MP0002822_catalepsy0.99824839
78MP0002572_abnormal_emotion/affect_behav0.97743727
79MP0003763_abnormal_thymus_physiology0.97237785
80MP0010030_abnormal_orbit_morphology0.97062963
81MP0004742_abnormal_vestibular_system0.96196099
82MP0002277_abnormal_respiratory_mucosa0.96009856
83MP0006276_abnormal_autonomic_nervous0.95070437
84MP0005248_abnormal_Harderian_gland0.92495653
85MP0002006_tumorigenesis0.90803557
86MP0003329_amyloid_beta_deposits0.88458446
87MP0002166_altered_tumor_susceptibility0.86073508
88MP0005165_increased_susceptibility_to0.86000461
89MP0009764_decreased_sensitivity_to0.85272607
90MP0005195_abnormal_posterior_eye0.81324388
91MP0002693_abnormal_pancreas_physiology0.80844205
92MP0001324_abnormal_eye_pigmentation0.80365989
93MP0001968_abnormal_touch/_nociception0.79552409
94MP0002160_abnormal_reproductive_system0.77220110
95MP0010386_abnormal_urinary_bladder0.76692384
96MP0001986_abnormal_taste_sensitivity0.76104617
97MP0003953_abnormal_hormone_level0.75230334
98MP0003283_abnormal_digestive_organ0.74611056
99MP0003436_decreased_susceptibility_to0.74123178
100MP0002837_dystrophic_cardiac_calcinosis0.73788338
101MP0003718_maternal_effect0.71813785
102MP0003879_abnormal_hair_cell0.71068429
103MP0002090_abnormal_vision0.69936387
104MP0000678_abnormal_parathyroid_gland0.69530363
105MP0003866_abnormal_defecation0.69506178
106MP0008569_lethality_at_weaning0.69065902
107MP0002148_abnormal_hypersensitivity_rea0.68849649
108MP0002177_abnormal_outer_ear0.68678880
109MP0005085_abnormal_gallbladder_physiolo0.68674327
110MP0004019_abnormal_vitamin_homeostasis0.67155161
111MP0002557_abnormal_social/conspecific_i0.66931788
112MP0002249_abnormal_larynx_morphology0.66646737
113MP0005391_vision/eye_phenotype0.66433385
114MP0002229_neurodegeneration0.65903002
115MP0000372_irregular_coat_pigmentation0.65374943
116MP0003011_delayed_dark_adaptation0.65263062
117MP0003315_abnormal_perineum_morphology0.64398371
118MP0008789_abnormal_olfactory_epithelium0.64079280
119MP0005023_abnormal_wound_healing0.62262513
120MP0005367_renal/urinary_system_phenotyp0.59746328
121MP0000516_abnormal_urinary_system0.59746328
122MP0002132_abnormal_respiratory_system0.59462659
123MP0001440_abnormal_grooming_behavior0.59273411
124MP0003121_genomic_imprinting0.57544940
125MP0005174_abnormal_tail_pigmentation0.56844315
126MP0000613_abnormal_salivary_gland0.56727515
127MP0000627_abnormal_mammary_gland0.56543705
128MP0002882_abnormal_neuron_morphology0.56542957
129MP0002078_abnormal_glucose_homeostasis0.55122458
130MP0005423_abnormal_somatic_nervous0.54269274
131MP0003195_calcinosis0.53955519
132MP0003638_abnormal_response/metabolism_0.53928138
133MP0005389_reproductive_system_phenotype0.53375262
134MP0002136_abnormal_kidney_physiology0.52747292
135MP0002752_abnormal_somatic_nervous0.52470307
136MP0003938_abnormal_ear_development0.52054428
137MP0002095_abnormal_skin_pigmentation0.51994918
138MP0000639_abnormal_adrenal_gland0.50865500
139MP0002736_abnormal_nociception_after0.50622101
140MP0003880_abnormal_central_pattern0.49218442
141MP0002234_abnormal_pharynx_morphology0.48997253
142MP0004264_abnormal_extraembryonic_tissu0.48918620
143MP0005076_abnormal_cell_differentiation0.48530348
144MP0008872_abnormal_physiological_respon0.48429718
145MP0001188_hyperpigmentation0.47047228
146MP0002233_abnormal_nose_morphology0.46985599
147MP0005394_taste/olfaction_phenotype0.46694764
148MP0005499_abnormal_olfactory_system0.46694764
149MP0002735_abnormal_chemical_nociception0.46230986
150MP0001784_abnormal_fluid_regulation0.45296435
151MP0003705_abnormal_hypodermis_morpholog0.42209105
152MP0009053_abnormal_anal_canal0.41967716
153MP0000470_abnormal_stomach_morphology0.40278997
154MP0006072_abnormal_retinal_apoptosis0.39635565
155MP0005409_darkened_coat_color0.39595464
156MP0005187_abnormal_penis_morphology0.39540496
157MP0005647_abnormal_sex_gland0.38453179
158MP0005408_hypopigmentation0.37131784
159MP0003755_abnormal_palate_morphology0.36308412
160MP0005508_abnormal_skeleton_morphology0.35051278
161MP0003724_increased_susceptibility_to0.33562431
162MP0009384_cardiac_valve_regurgitation0.33362087
163MP0001765_abnormal_ion_homeostasis0.32004060
164MP0002163_abnormal_gland_morphology0.31405642
165MP0000538_abnormal_urinary_bladder0.30549210
166MP0009250_abnormal_appendicular_skeleto0.30098612
167MP0001177_atelectasis0.30052553
168MP0005379_endocrine/exocrine_gland_phen0.29994478
169MP0001666_abnormal_nutrient_absorption0.29728492
170MP0001919_abnormal_reproductive_system0.28732106
171MP0003828_pulmonary_edema0.26890627
172MP0001873_stomach_inflammation0.26850182

Predicted human phenotypes

RankGene SetZ-score
1Congenital nonbullous ichthyosiform erythroderma (HP:0007479)8.69988682
2Amelogenesis imperfecta (HP:0000705)8.22200354
3Lip pit (HP:0100267)7.90376714
4Congenital ichthyosiform erythroderma (HP:0007431)7.75143931
5Overgrowth (HP:0001548)7.69018410
6Parakeratosis (HP:0001036)6.77192816
7Abnormality of calcium-phosphate metabolism (HP:0100530)6.69216907
8Hypotrichosis (HP:0001006)6.48580515
9Polyuria (HP:0000103)6.21398998
10Woolly hair (HP:0002224)6.08863628
11Abnormality of the dental pulp (HP:0006479)6.00336201
12Abnormality of renal resorption (HP:0011038)5.83048816
13Abnormality of dental color (HP:0011073)5.75194610
14Increased IgE level (HP:0003212)5.26169495
15Abnormal urine output (HP:0012590)5.14755291
16Right ventricular cardiomyopathy (HP:0011663)4.98496031
17Erythema (HP:0010783)4.88650489
18Osteomalacia (HP:0002749)4.71136434
19Natal tooth (HP:0000695)4.66252202
20Plantar hyperkeratosis (HP:0007556)4.63277467
21Abnormality of renal excretion (HP:0011036)4.59064886
22Popliteal pterygium (HP:0009756)4.58580464
23Palmoplantar hyperkeratosis (HP:0000972)4.56946660
24Abnormality of nail color (HP:0100643)4.56534262
25Abnormality of secondary sexual hair (HP:0009888)4.53481980
26Abnormality of the axillary hair (HP:0100134)4.53481980
27Sparse scalp hair (HP:0002209)4.41934177
28Palmar hyperkeratosis (HP:0010765)4.32390242
29Ectropion (HP:0000656)4.14756060
30Erythroderma (HP:0001019)4.09662152
31Molar tooth sign on MRI (HP:0002419)4.09579575
32Abnormality of midbrain morphology (HP:0002418)4.09579575
33Corneal erosion (HP:0200020)3.94920721
34Hypohidrosis (HP:0000966)3.87917006
35Abnormality of cells of the erythroid lineage (HP:0012130)3.85313579
36Gangrene (HP:0100758)3.77800941
37Abnormal hemoglobin (HP:0011902)3.68660354
38Pruritus (HP:0000989)3.66768089
39Fragile nails (HP:0001808)3.61932730
40Sparse eyelashes (HP:0000653)3.57490044
41Onycholysis (HP:0001806)3.55522135
42Congenital, generalized hypertrichosis (HP:0004540)3.48605263
43Oral leukoplakia (HP:0002745)3.46099971
44Advanced eruption of teeth (HP:0006288)3.45484436
45Decreased circulating renin level (HP:0003351)3.43450700
46Reticulocytopenia (HP:0001896)3.31689403
47Autoimmune thrombocytopenia (HP:0001973)3.30311174
48Tachypnea (HP:0002789)3.29811403
49Nephronophthisis (HP:0000090)3.28041215
50Hypoplastic labia majora (HP:0000059)3.21942578
51Abnormal number of erythroid precursors (HP:0012131)3.18655078
52Abnormality of the fovea (HP:0000493)3.17742973
53Abnormal blistering of the skin (HP:0008066)3.02312205
54Stenosis of the external auditory canal (HP:0000402)2.93137314
55Abnormality of the labia majora (HP:0012881)2.92051057
56Abnormality of the salivary glands (HP:0010286)2.89691262
57Dry hair (HP:0011359)2.88534118
58Duplicated collecting system (HP:0000081)2.87307694
59Anhidrosis (HP:0000970)2.84131652
60Hyporeflexia of lower limbs (HP:0002600)2.82274373
61Curly hair (HP:0002212)2.82123240
62Distal lower limb muscle weakness (HP:0009053)2.81774819
63Abnormality of the renal medulla (HP:0100957)2.80633036
64Rhinitis (HP:0012384)2.80600572
65Macrocytic anemia (HP:0001972)2.80535675
66Dry skin (HP:0000958)2.77929751
67IgM deficiency (HP:0002850)2.77502851
68Acanthosis nigricans (HP:0000956)2.75769280
69Pili torti (HP:0003777)2.74283247
70Concave nail (HP:0001598)2.72663190
71Palmoplantar keratoderma (HP:0000982)2.70479384
72Hyperactive renin-angiotensin system (HP:0000841)2.66015989
73Depressed nasal tip (HP:0000437)2.65758598
74Nail dystrophy (HP:0008404)2.63665297
75Round ear (HP:0100830)2.61483269
76Abnormal respiratory motile cilium physiology (HP:0012261)2.61328003
77Abnormality of the renal collecting system (HP:0004742)2.60020508
78Renal salt wasting (HP:0000127)2.54106796
79Ventricular tachycardia (HP:0004756)2.52420540
80Oligodontia (HP:0000677)2.50192513
81Hyperphosphaturia (HP:0003109)2.44100407
82Dehydration (HP:0001944)2.42924895
83Septate vagina (HP:0001153)2.40806713
84Brittle hair (HP:0002299)2.38325036
85Pallor (HP:0000980)2.35916689
86Areflexia of lower limbs (HP:0002522)2.32484557
87Nephrocalcinosis (HP:0000121)2.31408207
88Abnormality of renin-angiotensin system (HP:0000847)2.30523824
89Epidermoid cyst (HP:0200040)2.29749969
90Volvulus (HP:0002580)2.29258484
91Inability to walk (HP:0002540)2.28307607
92Nephropathy (HP:0000112)2.27226237
93Drooling (HP:0002307)2.26861288
94Absent eyebrow (HP:0002223)2.25967019
95Abnormal rod and cone electroretinograms (HP:0008323)2.25043630
96Abnormality of the gastric mucosa (HP:0004295)2.22289143
97Ectopic kidney (HP:0000086)2.22078169
98Glycosuria (HP:0003076)2.21214526
99Abnormality of urine glucose concentration (HP:0011016)2.21214526
100Conical tooth (HP:0000698)2.19347140
101Aplasia/Hypoplasia of the fovea (HP:0008060)2.18632536
102Hypoplasia of the fovea (HP:0007750)2.18632536
103Congenital stationary night blindness (HP:0007642)2.17855377
104Milia (HP:0001056)2.17254516
105Toxemia of pregnancy (HP:0100603)2.15525288
106Aplasia/hypoplasia of the uterus (HP:0008684)2.13298263
107Excessive salivation (HP:0003781)2.11239356
108Bronchitis (HP:0012387)2.10924069
109Pterygium (HP:0001059)2.07947606
110Skin pits (HP:0100276)2.07567754
111Hypoplasia of the uterus (HP:0000013)2.07383270
112Hypokalemic alkalosis (HP:0001949)2.05607243
113Ulnar claw (HP:0001178)2.04992902
114Labial hypoplasia (HP:0000066)2.04773524
115Abnormal urine phosphate concentration (HP:0012599)2.01481347
116Stage 5 chronic kidney disease (HP:0003774)1.99699421
117Nasolacrimal duct obstruction (HP:0000579)1.98916540
118Bifid scrotum (HP:0000048)1.98048785
119Type I diabetes mellitus (HP:0100651)1.97597469
120Lack of skin elasticity (HP:0100679)1.96710071
121Severe Myopia (HP:0011003)1.96615358
122Abnormal hair laboratory examination (HP:0003328)1.96235207
123Renal tubular dysfunction (HP:0000124)1.96101600
124Ketoacidosis (HP:0001993)1.96043164
125Abnormality of sodium homeostasis (HP:0010931)1.94275411
126Premature ovarian failure (HP:0008209)1.93431274
127Down-sloping shoulders (HP:0200021)1.92827507
128Hyperaldosteronism (HP:0000859)1.91976476
129Bony spicule pigmentary retinopathy (HP:0007737)1.91575948
130Polydipsia (HP:0001959)1.89273567
131Abnormal drinking behavior (HP:0030082)1.89273567
132True hermaphroditism (HP:0010459)1.87748086
133Chronic bronchitis (HP:0004469)1.86901564
134Abnormality of small intestinal villus morphology (HP:0011472)1.85441866
135Villous atrophy (HP:0011473)1.85441866
136Hypoglycemic seizures (HP:0002173)1.85424426
137Hypodontia (HP:0000668)1.83523059
138Hypoplastic female external genitalia (HP:0012815)1.83049796
139Abnormality of transition element cation homeostasis (HP:0011030)1.82604628
140Abnormality of the renal cortex (HP:0011035)1.81950111
141Hypomagnesemia (HP:0002917)1.81695211
142Thyroid-stimulating hormone excess (HP:0002925)1.81203642
143Cutaneous finger syndactyly (HP:0010554)1.78816010
144Aplasia/Hypoplasia of the macula (HP:0008059)1.78790674
145Hypergammaglobulinemia (HP:0010702)1.76752241
146Cupped ear (HP:0000378)1.76353472
147Paralysis (HP:0003470)1.75842732
148Sepsis (HP:0100806)1.74803039
149Choroideremia (HP:0001139)1.74599804
150Alopecia of scalp (HP:0002293)1.74452478
151Pustule (HP:0200039)1.74275284
152Thick eyebrow (HP:0000574)1.72900756
153Aplasia/Hypoplasia affecting the retina (HP:0008061)1.72323828
154Conjunctival hamartoma (HP:0100780)1.72195214
155Sex reversal (HP:0012245)1.71346811
156Abnormal sex determination (HP:0012244)1.71346811
157Ventricular fibrillation (HP:0001663)1.69706931
158Malignant hyperthermia (HP:0002047)1.69216071
159Hypoplasia of dental enamel (HP:0006297)1.69077095
160Hyperinsulinemic hypoglycemia (HP:0000825)1.68813225
161Hepatitis (HP:0012115)1.68077895
162Pendular nystagmus (HP:0012043)1.66588740
163Chorioretinal coloboma (HP:0000567)1.66201681
164Hoarse voice (HP:0001609)1.66087652
165Congenital sensorineural hearing impairment (HP:0008527)1.65624373
166Abnormality of the lacrimal duct (HP:0011481)1.65560137
167Pancreatic cysts (HP:0001737)1.64997032
168Depressed nasal ridge (HP:0000457)1.64243290
169Attenuation of retinal blood vessels (HP:0007843)1.63885261
170Esophageal varix (HP:0002040)1.63249763
171Corneal dystrophy (HP:0001131)1.61345174
172Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.60153704
173Hypoparathyroidism (HP:0000829)1.59839824
174Abnormal delayed hypersensitivity skin test (HP:0002963)1.59556085
175Abnormality of the distal phalanges of the toes (HP:0010182)1.59297917
176Bronchiectasis (HP:0002110)1.57281049
177Abnormality of macular pigmentation (HP:0008002)1.55287008
178Aplasia involving bones of the extremities (HP:0009825)1.53667905
179Aplasia of the phalanges of the hand (HP:0009802)1.53667905
180Tubular atrophy (HP:0000092)1.52651808
181Pancreatic fibrosis (HP:0100732)1.52445023

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST45.48690535
2MAP4K15.42145341
3MAPKAPK34.60699160
4MAP3K34.26467681
5STK33.58400253
6TAOK33.57921542
7MST1R3.25213828
8MAP3K23.12364584
9RPS6KB22.69307490
10FER2.46241670
11PIM22.45142076
12MAPK152.27932009
13ERBB31.99668567
14TRPM71.97489674
15TESK11.94337515
16MAP3K141.82615164
17EPHB21.74277461
18BMPR1B1.72674644
19STK391.72070590
20STK101.66666924
21MAPKAPK51.65042954
22STK241.58466474
23IRAK31.58413754
24WNK41.55081063
25LRRK21.39403054
26CDK31.39364974
27GRK11.37502521
28GRK71.35965546
29ITK1.35915637
30PIK3CG1.30800464
31BLK1.24162029
32BMPR21.17403067
33EPHA31.15738990
34TLK11.15666325
35HIPK21.14200705
36NME21.12275877
37TNK21.11500469
38WNK31.10142333
39DYRK1B1.09075021
40IKBKE1.06799821
41FGFR41.05151418
42MAP2K61.04730972
43CDC42BPA1.03488744
44NLK1.03462408
45PHKG10.99587196
46PHKG20.99587196
47ERN10.99200114
48IKBKB0.97547755
49LIMK10.95643428
50TGFBR20.95068416
51PTK60.94667055
52BCR0.91466955
53FGFR10.91212357
54BCKDK0.89797639
55INSRR0.89684545
56FRK0.89478990
57TYK20.89432692
58EIF2AK20.86046572
59MAP4K20.83158119
60CASK0.83004252
61AKT30.81839083
62PRKCQ0.81823489
63MAP2K20.81821951
64MAPKAPK20.80538485
65TEC0.80518997
66MUSK0.79729063
67OXSR10.79493712
68LATS10.79000598
69TGFBR10.75943754
70TNIK0.74935240
71MET0.73647921
72CDK60.73354667
73FGFR20.73028182
74PRKAA10.71172804
75MAP3K10.68998149
76ADRBK10.67732675
77FES0.66522039
78CDK190.65886233
79SYK0.65142706
80PASK0.64806999
81GRK50.64628875
82TXK0.61945317
83CHUK0.61413184
84RIPK40.59050213
85PINK10.57363369
86PAK30.56595128
87PRKCE0.55001292
88PRKACA0.54029037
89MAP3K70.53990089
90MAP3K120.53872095
91NTRK20.52768945
92BTK0.52753569
93DAPK20.51979771
94STK160.49110098
95SRPK10.47814513
96FGFR30.47770696
97TIE10.45865729
98MAP2K30.45150808
99TAOK10.44157644
100MAPK130.43625074
101RPS6KA10.42742777
102FLT30.42640088
103MAP3K110.42618008
104PRKCG0.41799799
105KIT0.41011099
106PKN10.40262473
107CSNK1A10.39835284
108MAPK120.39734875
109PRKACG0.39475708
110SRC0.39306719
111STK38L0.39139235
112ZAK0.37665735
113IRAK20.37217483
114PRKD10.36912567
115ROCK20.36290844
116SGK10.36195276
117RPS6KA40.36023003
118JAK20.35634137
119OBSCN0.35508509
120NUAK10.35248593
121CAMK2A0.35153699
122ILK0.34785847
123PNCK0.34347551
124YES10.34171994
125CSNK1G10.33520082
126GRK60.33235613
127EPHA20.32867770
128ROCK10.32733982
129JAK10.32410681
130PRKCA0.31919748
131VRK10.31587356
132ADRBK20.31533679
133ABL10.31350856
134RIPK10.31192934
135PRKAA20.30681437
136PRKACB0.30315460
137CSNK1D0.29661153
138RPS6KA50.29356443
139ACVR1B0.28439922
140TBK10.27959925
141RPS6KL10.27851620
142RPS6KC10.27851620
143MAP3K50.27782614
144CAMK10.27701742
145MOS0.27470876
146DYRK1A0.27053536
147SGK2230.25748787
148SGK4940.25748787
149DDR20.25552679
150CAMKK20.25359314
151ERBB40.24257369
152LYN0.22947362
153IGF1R0.22271810
154MAPK70.21015973
155NTRK30.20291794
156ZAP700.18544137
157PLK10.17980339

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004605.23409602
2Ribosome_Homo sapiens_hsa030105.07189080
3Sphingolipid metabolism_Homo sapiens_hsa006003.93241976
4Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.56663339
5Arachidonic acid metabolism_Homo sapiens_hsa005903.12242138
6Linoleic acid metabolism_Homo sapiens_hsa005912.95477234
7Sulfur relay system_Homo sapiens_hsa041222.94345569
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.90747654
9Fatty acid elongation_Homo sapiens_hsa000622.47279734
10Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.12828374
11Retinol metabolism_Homo sapiens_hsa008302.12649864
12Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.09521778
13Histidine metabolism_Homo sapiens_hsa003402.06042055
14Salivary secretion_Homo sapiens_hsa049702.03347796
15Thyroid hormone synthesis_Homo sapiens_hsa049182.01051802
16Insulin secretion_Homo sapiens_hsa049111.90111345
17Synaptic vesicle cycle_Homo sapiens_hsa047211.89603815
18Bile secretion_Homo sapiens_hsa049761.89292813
19Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.87690059
20Chemical carcinogenesis_Homo sapiens_hsa052041.83535416
21Phenylalanine metabolism_Homo sapiens_hsa003601.79129568
22Circadian entrainment_Homo sapiens_hsa047131.75341002
23Ether lipid metabolism_Homo sapiens_hsa005651.73898569
24Glutamatergic synapse_Homo sapiens_hsa047241.66808999
25Cocaine addiction_Homo sapiens_hsa050301.63039114
26GABAergic synapse_Homo sapiens_hsa047271.56588943
27Morphine addiction_Homo sapiens_hsa050321.50385341
28Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.44916913
29Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.42865850
30Aldosterone synthesis and secretion_Homo sapiens_hsa049251.42434793
31SNARE interactions in vesicular transport_Homo sapiens_hsa041301.41833698
32Steroid hormone biosynthesis_Homo sapiens_hsa001401.33309727
33ABC transporters_Homo sapiens_hsa020101.29289908
34Maturity onset diabetes of the young_Homo sapiens_hsa049501.27075692
35Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.26420244
36Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.23134552
37Collecting duct acid secretion_Homo sapiens_hsa049661.17951214
38Amphetamine addiction_Homo sapiens_hsa050311.15656377
39Pyruvate metabolism_Homo sapiens_hsa006201.13290060
40Phototransduction_Homo sapiens_hsa047441.10738840
41Longevity regulating pathway - mammal_Homo sapiens_hsa042111.09358545
42Serotonergic synapse_Homo sapiens_hsa047261.08137685
43Dilated cardiomyopathy_Homo sapiens_hsa054141.06163267
44Parkinsons disease_Homo sapiens_hsa050121.04015135
45Gap junction_Homo sapiens_hsa045401.03299511
46Glutathione metabolism_Homo sapiens_hsa004801.00302426
47Basal cell carcinoma_Homo sapiens_hsa052171.00015070
48p53 signaling pathway_Homo sapiens_hsa041150.99746039
49Tyrosine metabolism_Homo sapiens_hsa003500.96815933
50Sphingolipid signaling pathway_Homo sapiens_hsa040710.94467960
51Oxytocin signaling pathway_Homo sapiens_hsa049210.93095520
52Calcium signaling pathway_Homo sapiens_hsa040200.90108125
53Caffeine metabolism_Homo sapiens_hsa002320.90036756
54Pancreatic secretion_Homo sapiens_hsa049720.86160464
55Renin secretion_Homo sapiens_hsa049240.86067414
56Dorso-ventral axis formation_Homo sapiens_hsa043200.84189718
57Adherens junction_Homo sapiens_hsa045200.81704610
58Cholinergic synapse_Homo sapiens_hsa047250.81436101
59Folate biosynthesis_Homo sapiens_hsa007900.79796221
60Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.77972636
61Tight junction_Homo sapiens_hsa045300.76286863
62Graft-versus-host disease_Homo sapiens_hsa053320.76216091
63Jak-STAT signaling pathway_Homo sapiens_hsa046300.76050308
64Butanoate metabolism_Homo sapiens_hsa006500.75812969
65Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.74592000
66Axon guidance_Homo sapiens_hsa043600.71586116
67Pentose and glucuronate interconversions_Homo sapiens_hsa000400.71410703
68Circadian rhythm_Homo sapiens_hsa047100.67658765
69Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.67545319
70Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.67306938
71Nitrogen metabolism_Homo sapiens_hsa009100.66927197
72Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.66772152
73Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.65405462
74Pertussis_Homo sapiens_hsa051330.65345986
75RNA degradation_Homo sapiens_hsa030180.65140895
76Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.64095596
77NOD-like receptor signaling pathway_Homo sapiens_hsa046210.63966507
78Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.63407886
79Sulfur metabolism_Homo sapiens_hsa009200.62838470
80Melanogenesis_Homo sapiens_hsa049160.62733472
81Mineral absorption_Homo sapiens_hsa049780.62673136
82VEGF signaling pathway_Homo sapiens_hsa043700.62074853
83Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.60464528
84Vibrio cholerae infection_Homo sapiens_hsa051100.59860041
85Estrogen signaling pathway_Homo sapiens_hsa049150.58957256
86beta-Alanine metabolism_Homo sapiens_hsa004100.58915402
87Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.57361068
88Oxidative phosphorylation_Homo sapiens_hsa001900.57350814
89Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.56925464
90Hepatitis C_Homo sapiens_hsa051600.54325083
91Olfactory transduction_Homo sapiens_hsa047400.54281449
92T cell receptor signaling pathway_Homo sapiens_hsa046600.53992299
93Protein export_Homo sapiens_hsa030600.53150835
94Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.53027974
95Hematopoietic cell lineage_Homo sapiens_hsa046400.52515824
96Leukocyte transendothelial migration_Homo sapiens_hsa046700.52315068
97Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.51701748
98Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.50329274
99Fat digestion and absorption_Homo sapiens_hsa049750.49574134
100Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.49181754
101Rheumatoid arthritis_Homo sapiens_hsa053230.49131466
102Ras signaling pathway_Homo sapiens_hsa040140.47798092
103Taste transduction_Homo sapiens_hsa047420.45476389
104Hippo signaling pathway_Homo sapiens_hsa043900.44847309
105Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.43924488
106Primary immunodeficiency_Homo sapiens_hsa053400.43119491
107Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.43009837
108Glycerophospholipid metabolism_Homo sapiens_hsa005640.42906227
109Dopaminergic synapse_Homo sapiens_hsa047280.42783026
110GnRH signaling pathway_Homo sapiens_hsa049120.42295584
111Platelet activation_Homo sapiens_hsa046110.42014687
112Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.41037856
113cAMP signaling pathway_Homo sapiens_hsa040240.40411806
114Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.38738852
115Ovarian steroidogenesis_Homo sapiens_hsa049130.38225463
116Other glycan degradation_Homo sapiens_hsa005110.37210267
117Vitamin digestion and absorption_Homo sapiens_hsa049770.36216004
118Staphylococcus aureus infection_Homo sapiens_hsa051500.34756561
119Tryptophan metabolism_Homo sapiens_hsa003800.34048501
120Transcriptional misregulation in cancer_Homo sapiens_hsa052020.33846037
121TGF-beta signaling pathway_Homo sapiens_hsa043500.33709886
122Wnt signaling pathway_Homo sapiens_hsa043100.33706185
123Thyroid cancer_Homo sapiens_hsa052160.33526388
124Vascular smooth muscle contraction_Homo sapiens_hsa042700.33428659
125Purine metabolism_Homo sapiens_hsa002300.33404842
126Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.32182163
127Proteoglycans in cancer_Homo sapiens_hsa052050.30464929
128Legionellosis_Homo sapiens_hsa051340.30123541
129Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.30008422
130cGMP-PKG signaling pathway_Homo sapiens_hsa040220.29696379
131Toxoplasmosis_Homo sapiens_hsa051450.29120327
132Alcoholism_Homo sapiens_hsa050340.28350544
133Primary bile acid biosynthesis_Homo sapiens_hsa001200.27255891
134NF-kappa B signaling pathway_Homo sapiens_hsa040640.27082100
135Oocyte meiosis_Homo sapiens_hsa041140.26702792
136Gastric acid secretion_Homo sapiens_hsa049710.26445132
137Hedgehog signaling pathway_Homo sapiens_hsa043400.26350682
138ECM-receptor interaction_Homo sapiens_hsa045120.25490039
139Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.25242360
140Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.25132504
141TNF signaling pathway_Homo sapiens_hsa046680.24013345
142Alzheimers disease_Homo sapiens_hsa050100.23646945
143Type I diabetes mellitus_Homo sapiens_hsa049400.23574593
144Bladder cancer_Homo sapiens_hsa052190.23442019
145Nicotine addiction_Homo sapiens_hsa050330.23013889
146MicroRNAs in cancer_Homo sapiens_hsa052060.22888478
147Cysteine and methionine metabolism_Homo sapiens_hsa002700.22116343
148Amoebiasis_Homo sapiens_hsa051460.21628279
149Huntingtons disease_Homo sapiens_hsa050160.20761340

Most similar genes based on co-expression Upload to Enrichr

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