DAZAP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: In mammals, the Y chromosome directs the development of the testes and plays an important role in spermatogenesis. A high percentage of infertile men have deletions that map to regions of the Y chromosome. The DAZ (deleted in azoospermia) gene cluster maps to the AZFc region of the Y chromosome and is deleted in many azoospermic and severely oligospermic men. It is thought that the DAZ gene cluster arose from the transposition, amplification, and pruning of the ancestral autosomal gene DAZL also involved in germ cell development and gametogenesis. This gene encodes a RNA-binding protein with two RNP motifs that was originally identified by its interaction with the infertility factors DAZ and DAZL. Two isoforms are encoded by transcript variants of this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)4.70613158
2heterochromatin organization (GO:0070828)4.60089872
3protein localization to kinetochore (GO:0034501)4.15719242
4regulation of translational fidelity (GO:0006450)4.14177962
5viral transcription (GO:0019083)4.09579109
6nuclear pore complex assembly (GO:0051292)3.99266693
7translational termination (GO:0006415)3.92892406
8nuclear pore organization (GO:0006999)3.91699640
9negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.89266808
10folic acid-containing compound biosynthetic process (GO:0009396)3.87326576
11pre-miRNA processing (GO:0031054)3.78803629
12chromatin assembly (GO:0031497)3.76132102
13negative regulation of erythrocyte differentiation (GO:0045647)3.75393226
14regulation of posttranscriptional gene silencing (GO:0060147)3.74549187
15regulation of gene silencing by miRNA (GO:0060964)3.74549187
16regulation of gene silencing by RNA (GO:0060966)3.74549187
17proline biosynthetic process (GO:0006561)3.74243429
18dosage compensation (GO:0007549)3.73762807
19RNA stabilization (GO:0043489)3.73200156
20mRNA stabilization (GO:0048255)3.73200156
21mitotic sister chromatid segregation (GO:0000070)3.70771832
22sister chromatid segregation (GO:0000819)3.69855751
23regulation of mammary gland epithelial cell proliferation (GO:0033599)3.67543507
24protein complex localization (GO:0031503)3.64777329
25negative regulation of RNA splicing (GO:0033119)3.62648296
26nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.57903930
27protein localization to chromosome, centromeric region (GO:0071459)3.55732362
28negative regulation of mRNA processing (GO:0050686)3.49406225
29translational elongation (GO:0006414)3.47964639
30mitotic nuclear envelope disassembly (GO:0007077)3.44903827
313-UTR-mediated mRNA stabilization (GO:0070935)3.42077419
32DNA replication-dependent nucleosome assembly (GO:0006335)3.38755789
33DNA replication-dependent nucleosome organization (GO:0034723)3.38755789
34regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.38545685
35cellular protein complex localization (GO:0034629)3.34268312
36DNA duplex unwinding (GO:0032508)3.33644078
37ribosomal small subunit biogenesis (GO:0042274)3.32268549
38translational initiation (GO:0006413)3.30585778
39negative regulation of mRNA metabolic process (GO:1903312)3.29751563
40DNA geometric change (GO:0032392)3.29173881
41spliceosomal tri-snRNP complex assembly (GO:0000244)3.28050835
42regulation of histone H3-K27 methylation (GO:0061085)3.26971045
43regulation of histone H3-K9 methylation (GO:0051570)3.24184290
44nuclear envelope disassembly (GO:0051081)3.21638539
45membrane disassembly (GO:0030397)3.21638539
46regulation of nucleobase-containing compound transport (GO:0032239)3.19584197
47apoptotic process involved in morphogenesis (GO:0060561)3.18833796
48trophectodermal cell differentiation (GO:0001829)3.16926543
49negative regulation of histone methylation (GO:0031061)3.13344730
50intracellular estrogen receptor signaling pathway (GO:0030520)3.13328673
51pentose-phosphate shunt (GO:0006098)3.12122410
52protein complex disassembly (GO:0043241)3.11523160
53viral life cycle (GO:0019058)3.10025184
54cellular protein complex disassembly (GO:0043624)3.09421994
55positive regulation of chromosome segregation (GO:0051984)3.08411446
56mitotic sister chromatid cohesion (GO:0007064)3.08218298
57adherens junction assembly (GO:0034333)3.02729061
58nucleosome disassembly (GO:0006337)3.01476626
59protein-DNA complex disassembly (GO:0032986)3.01476626
60cell-substrate adherens junction assembly (GO:0007045)3.00858149
61focal adhesion assembly (GO:0048041)3.00858149
62establishment of apical/basal cell polarity (GO:0035089)3.00207972
63regulation of hippo signaling (GO:0035330)2.99360251
64mitotic chromosome condensation (GO:0007076)2.98863924
65formation of translation preinitiation complex (GO:0001731)2.98394193
66pore complex assembly (GO:0046931)2.98173449
67DNA strand elongation involved in DNA replication (GO:0006271)2.97666879
68protein export from nucleus (GO:0006611)2.97159973
69ncRNA 3-end processing (GO:0043628)2.95214864
70establishment of integrated proviral latency (GO:0075713)2.93876561
71peptidyl-arginine omega-N-methylation (GO:0035247)2.92708551
72regulation of RNA export from nucleus (GO:0046831)2.92368994
73positive regulation of histone deacetylation (GO:0031065)2.90824456
74DNA replication initiation (GO:0006270)2.90363148
75histone arginine methylation (GO:0034969)2.89186879
76SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.89048602
77ribosomal small subunit assembly (GO:0000028)2.88732275
78regulation of mRNA stability (GO:0043488)2.87747734
79regulation of NFAT protein import into nucleus (GO:0051532)2.85853668
80maturation of SSU-rRNA (GO:0030490)2.85531212
81regulation of translational termination (GO:0006449)2.83616730
82protein targeting to ER (GO:0045047)2.83088299
83COPI coating of Golgi vesicle (GO:0048205)2.82707474
84Golgi transport vesicle coating (GO:0048200)2.82707474
85macromolecular complex disassembly (GO:0032984)2.80887159
86peptidyl-lysine dimethylation (GO:0018027)2.80218721
87DNA strand elongation (GO:0022616)2.77526527
88cotranslational protein targeting to membrane (GO:0006613)2.77232569
89positive regulation of SMAD protein import into nucleus (GO:0060391)2.77195255
90alternative mRNA splicing, via spliceosome (GO:0000380)2.73613012
91embryonic process involved in female pregnancy (GO:0060136)2.71360325
92regulation of protein heterodimerization activity (GO:0043497)2.71277133
93nuclear-transcribed mRNA catabolic process (GO:0000956)2.71194306
94positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.71183252
95mannose metabolic process (GO:0006013)2.70294741
96establishment of protein localization to endoplasmic reticulum (GO:0072599)2.70277967
97nuclear envelope organization (GO:0006998)2.69974378
98positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.69565746
99regulation of RNA stability (GO:0043487)2.68686692
100regulation of glucose import in response to insulin stimulus (GO:2001273)2.68677984
101peptidyl-arginine methylation (GO:0018216)2.68642564
102peptidyl-arginine N-methylation (GO:0035246)2.68642564
103DNA conformation change (GO:0071103)2.68007707
104telomere maintenance via semi-conservative replication (GO:0032201)2.67724326
105NADPH regeneration (GO:0006740)2.66922340
106termination of RNA polymerase II transcription (GO:0006369)2.66749478
107planar cell polarity pathway involved in neural tube closure (GO:0090179)2.66611217
108activation of Rac GTPase activity (GO:0032863)2.66561450
109regulation of stem cell maintenance (GO:2000036)2.66526902
110cellular hyperosmotic response (GO:0071474)2.66045867
111RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.65222763
112mRNA splicing, via spliceosome (GO:0000398)2.65222763
113RNA catabolic process (GO:0006401)2.64791257
114regulation of early endosome to late endosome transport (GO:2000641)2.64731600
115regulation of sister chromatid cohesion (GO:0007063)2.64534332
116ribonucleoprotein complex biogenesis (GO:0022613)2.64372803
117positive regulation of RNA splicing (GO:0033120)2.64190059
118chromosome condensation (GO:0030261)2.63821433
119RNA splicing, via transesterification reactions (GO:0000375)2.63653489
120glucocorticoid receptor signaling pathway (GO:0042921)2.63435271
121chromatin silencing (GO:0006342)2.62046807
122negative regulation of gene expression, epigenetic (GO:0045814)2.61750914
123DNA packaging (GO:0006323)2.59536851
124mRNA catabolic process (GO:0006402)2.59029256
125modulation by virus of host process (GO:0019054)2.57816270
126regulation of chromatin binding (GO:0035561)2.57557706
127negative regulation of cell size (GO:0045792)2.57243135
128histone H3-K36 demethylation (GO:0070544)2.56663915
129mitotic G1 DNA damage checkpoint (GO:0031571)2.55971268
130viral mRNA export from host cell nucleus (GO:0046784)2.55657349
131regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.55437304
132cellular response to epidermal growth factor stimulus (GO:0071364)2.54602032
133glucose catabolic process (GO:0006007)2.54268269
134gene silencing (GO:0016458)2.53130031
135protein localization to endoplasmic reticulum (GO:0070972)2.53014826
136chromatin assembly or disassembly (GO:0006333)2.52914384
137nucleobase-containing small molecule interconversion (GO:0015949)2.52212494
138DNA topological change (GO:0006265)2.51909883
139maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.51651806
140regulation of gene silencing (GO:0060968)2.50700713
141folic acid metabolic process (GO:0046655)2.50642993
142pinocytosis (GO:0006907)2.50179292
143IMP biosynthetic process (GO:0006188)2.49936119
144modulation by symbiont of host cellular process (GO:0044068)2.49827965
145protein localization to chromosome (GO:0034502)2.48485895

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.84891870
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.66767798
3* MYC_22102868_ChIP-Seq_BL_Human3.25892863
4* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.11843498
5MYC_18555785_ChIP-Seq_MESCs_Mouse2.84503246
6E2F4_17652178_ChIP-ChIP_JURKAT_Human2.81513517
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.70609133
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.70267070
9VDR_21846776_ChIP-Seq_THP-1_Human2.54557014
10MYC_19079543_ChIP-ChIP_MESCs_Mouse2.42837842
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.25317013
12TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.18037351
13SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.07133746
14MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.91017808
15STAT6_21828071_ChIP-Seq_BEAS2B_Human1.86961306
16XRN2_22483619_ChIP-Seq_HELA_Human1.85266946
17* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.84424000
18TP63_17297297_ChIP-ChIP_HaCaT_Human1.81057996
19TCF7_22412390_ChIP-Seq_EML_Mouse1.80729663
20NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.78691806
21KDM2B_26808549_Chip-Seq_DND41_Human1.73688918
22* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.67136459
23* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.66991439
24ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.66351906
25ELK3_25401928_ChIP-Seq_HUVEC_Human1.65514886
26PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.59610320
27E2F1_21310950_ChIP-Seq_MCF-7_Human1.59255676
28STAT3_1855785_ChIP-Seq_MESCs_Mouse1.57389497
29* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.57025905
30* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.50929128
31* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.49937203
32KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.48849511
33UTX_26944678_Chip-Seq_JUKART_Human1.48191076
34KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.47041971
35KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.47041971
36KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.47041971
37NELFA_20434984_ChIP-Seq_ESCs_Mouse1.46789095
38MAF_26560356_Chip-Seq_TH1_Human1.45618426
39EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.43805591
40CIITA_25753668_ChIP-Seq_RAJI_Human1.43277346
41* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.40845869
42* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.39767485
43RARG_19884340_ChIP-ChIP_MEFs_Mouse1.39126982
44MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.37245711
45POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.35904472
46* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.35784200
47* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.34819806
48AR_21909140_ChIP-Seq_LNCAP_Human1.31293378
49NANOG_18555785_ChIP-Seq_MESCs_Mouse1.30840779
50TP63_19390658_ChIP-ChIP_HaCaT_Human1.29966898
51KDM5A_27292631_Chip-Seq_BREAST_Human1.29887532
52POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.29514552
53CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.28425906
54CLOCK_20551151_ChIP-Seq_293T_Human1.28223834
55ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.28167373
56THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.26828241
57* LXR_22292898_ChIP-Seq_THP-1_Human1.26487306
58ZNF263_19887448_ChIP-Seq_K562_Human1.25902877
59* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.25770672
60* P68_20966046_ChIP-Seq_HELA_Human1.25553516
61ZFP281_18757296_ChIP-ChIP_E14_Mouse1.24542609
62* TET1_21451524_ChIP-Seq_MESCs_Mouse1.23847576
63KDM2B_26808549_Chip-Seq_K562_Human1.23703302
64KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.21907929
65RACK7_27058665_Chip-Seq_MCF-7_Human1.21274414
66KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.20267643
67STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.17606265
68ZFP281_27345836_Chip-Seq_ESCs_Mouse1.17072250
69SOX2_18555785_ChIP-Seq_MESCs_Mouse1.16898205
70ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.16832846
71* NCOR1_26117541_ChIP-Seq_K562_Human1.16827003
72VDR_24763502_ChIP-Seq_THP-1_Human1.16757161
73* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.16508271
74ATF3_27146783_Chip-Seq_COLON_Human1.14756072
75HIF1A_21447827_ChIP-Seq_MCF-7_Human1.14627638
76NANOG_21062744_ChIP-ChIP_HESCs_Human1.14422897
77* MAF_26560356_Chip-Seq_TH2_Human1.14031961
78SA1_27219007_Chip-Seq_ERYTHROID_Human1.13256754
79* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.12744410
80* TTF2_22483619_ChIP-Seq_HELA_Human1.11470034
81SRY_22984422_ChIP-ChIP_TESTIS_Rat1.11441230
82UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.11145264
83* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.11125583
84* ETS1_20019798_ChIP-Seq_JURKAT_Human1.10221252
85TCF3_18692474_ChIP-Seq_MEFs_Mouse1.08655990
86SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.08279449
87HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.07760909
88CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.07194026
89CREB1_26743006_Chip-Seq_LNCaP_Human1.06800518
90P300_27058665_Chip-Seq_ZR-75-30cells_Human1.05909760
91* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.05628583
92KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.05438011
93RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.04559427
94BRD4_27068464_Chip-Seq_AML-cells_Mouse1.03355229
95* KDM2B_26808549_Chip-Seq_JURKAT_Human1.02796694
96CREB1_15753290_ChIP-ChIP_HEK293T_Human1.02328771
97DCP1A_22483619_ChIP-Seq_HELA_Human1.01717796
98* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.01690134
99HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.00449782
100ESR1_15608294_ChIP-ChIP_MCF-7_Human1.00349617
101SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.99865082
102CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.99847092
103FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.99595164
104TP53_22127205_ChIP-Seq_IMR90_Human0.99469377
105* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.99391235
106CHD1_26751641_Chip-Seq_LNCaP_Human0.98750353
107FOXP3_21729870_ChIP-Seq_TREG_Human0.97723821
108TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.97146914
109GABP_19822575_ChIP-Seq_HepG2_Human0.96548921
110NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.95198616
111TFEB_21752829_ChIP-Seq_HELA_Human0.94936798
112CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.94625385
113SMC4_20622854_ChIP-Seq_HELA_Human0.94571241
114* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.94517427
115CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.94261038
116SCL_19346495_ChIP-Seq_HPC-7_Human0.94088955
117WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.93900340
118MYB_26560356_Chip-Seq_TH1_Human0.93819658
119JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.93759551
120ELF1_20517297_ChIP-Seq_JURKAT_Human0.93670425
121TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.93637875
122* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.92629449
123TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.92191049
124* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.92160276
125RUNX1_22412390_ChIP-Seq_EML_Mouse0.91525216
126SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.91479658
127EST1_17652178_ChIP-ChIP_JURKAT_Human0.91451260

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.41873822
2MP0010352_gastrointestinal_tract_polyps3.10005435
3MP0003111_abnormal_nucleus_morphology2.93442280
4MP0004957_abnormal_blastocyst_morpholog2.71342521
5MP0003693_abnormal_embryo_hatching2.62577040
6MP0008057_abnormal_DNA_replication2.59450740
7MP0005451_abnormal_body_composition2.59321970
8MP0005076_abnormal_cell_differentiation2.58492639
9MP0010094_abnormal_chromosome_stability2.53548609
10MP0003077_abnormal_cell_cycle2.47168159
11MP0001730_embryonic_growth_arrest2.16544450
12MP0009278_abnormal_bone_marrow2.11251514
13MP0010030_abnormal_orbit_morphology2.06734233
14MP0010307_abnormal_tumor_latency2.01046050
15MP0004197_abnormal_fetal_growth/weight/1.97954154
16MP0000350_abnormal_cell_proliferation1.94796970
17MP0000678_abnormal_parathyroid_gland1.81845952
18MP0009053_abnormal_anal_canal1.81370318
19MP0005380_embryogenesis_phenotype1.74699822
20MP0001672_abnormal_embryogenesis/_devel1.74699822
21MP0002085_abnormal_embryonic_tissue1.70601635
22MP0002084_abnormal_developmental_patter1.69164672
23MP0000537_abnormal_urethra_morphology1.67908132
24MP0001697_abnormal_embryo_size1.67467493
25MP0003984_embryonic_growth_retardation1.65784148
26MP0002088_abnormal_embryonic_growth/wei1.65233207
27MP0002086_abnormal_extraembryonic_tissu1.64699076
28MP0003566_abnormal_cell_adhesion1.64353174
29MP0005666_abnormal_adipose_tissue1.61911618
30MP0010234_abnormal_vibrissa_follicle1.61607215
31MP0001849_ear_inflammation1.60920365
32MP0002396_abnormal_hematopoietic_system1.58926869
33MP0002653_abnormal_ependyma_morphology1.58787231
34MP0000733_abnormal_muscle_development1.54943978
35MP0008932_abnormal_embryonic_tissue1.54264269
36MP0002080_prenatal_lethality1.50730313
37MP0008007_abnormal_cellular_replicative1.49059482
38MP0008260_abnormal_autophagy1.47882396
39MP0003300_gastrointestinal_ulcer1.47356781
40MP0000490_abnormal_crypts_of1.45818581
41MP0004185_abnormal_adipocyte_glucose1.40740340
42MP0004858_abnormal_nervous_system1.37261069
43MP0003567_abnormal_fetal_cardiomyocyte1.36453629
44MP0003123_paternal_imprinting1.33968803
45MP0005023_abnormal_wound_healing1.33769838
46MP0003119_abnormal_digestive_system1.31779909
47MP0005058_abnormal_lysosome_morphology1.30515799
48MP0005623_abnormal_meninges_morphology1.29694785
49MP0002089_abnormal_postnatal_growth/wei1.29005571
50MP0004808_abnormal_hematopoietic_stem1.28465968
51MP0005375_adipose_tissue_phenotype1.26576396
52MP0001545_abnormal_hematopoietic_system1.24697366
53MP0005397_hematopoietic_system_phenotyp1.24697366
54MP0009333_abnormal_splenocyte_physiolog1.20433302
55MP0001661_extended_life_span1.19856115
56MP0000703_abnormal_thymus_morphology1.19796753
57MP0004947_skin_inflammation1.18460862
58MP0002009_preneoplasia1.18333267
59MP0001915_intracranial_hemorrhage1.17455627
60MP0000313_abnormal_cell_death1.16555336
61MP0008438_abnormal_cutaneous_collagen1.16174740
62MP0003303_peritoneal_inflammation1.16098178
63MP0002019_abnormal_tumor_incidence1.15879312
64MP0001293_anophthalmia1.15659493
65MP0009672_abnormal_birth_weight1.12915524
66MP0002254_reproductive_system_inflammat1.12771524
67MP0002877_abnormal_melanocyte_morpholog1.12469491
68MP0000003_abnormal_adipose_tissue1.11046477
69MP0009379_abnormal_foot_pigmentation1.10881067
70MP0005621_abnormal_cell_physiology1.09868413
71MP0005409_darkened_coat_color1.09522263
72MP0001873_stomach_inflammation1.08230203
73MP0002697_abnormal_eye_size1.07845585
74MP0003115_abnormal_respiratory_system1.07789738
75MP0003453_abnormal_keratinocyte_physiol1.07162209
76MP0008058_abnormal_DNA_repair1.06969120
77MP0002925_abnormal_cardiovascular_devel1.06702200
78MP0002092_abnormal_eye_morphology1.05005061
79MP0009703_decreased_birth_body1.04845634
80MP0000428_abnormal_craniofacial_morphol1.04654739
81MP0002111_abnormal_tail_morphology1.04268154
82MP0004264_abnormal_extraembryonic_tissu1.02068988
83MP0005501_abnormal_skin_physiology0.99132852
84MP0003763_abnormal_thymus_physiology0.98827288
85MP0002398_abnormal_bone_marrow0.97459353
86MP0003436_decreased_susceptibility_to0.97081514
87MP0008770_decreased_survivor_rate0.96909283
88MP0001348_abnormal_lacrimal_gland0.94435182
89MP0003385_abnormal_body_wall0.93800489
90MP0010630_abnormal_cardiac_muscle0.93092203
91MP0002722_abnormal_immune_system0.92972164
92MP0002932_abnormal_joint_morphology0.91750408
93MP0000467_abnormal_esophagus_morphology0.91202121
94MP0003786_premature_aging0.90577067
95MP0003935_abnormal_craniofacial_develop0.89703910
96MP0000685_abnormal_immune_system0.89400418
97MP0004233_abnormal_muscle_weight0.88727493
98MP0009840_abnormal_foam_cell0.86770321
99MP0000477_abnormal_intestine_morphology0.85934689
100MP0002282_abnormal_trachea_morphology0.85505443
101MP0000432_abnormal_head_morphology0.85263904
102MP0005384_cellular_phenotype0.83382861
103MP0000750_abnormal_muscle_regeneration0.83131726
104MP0000689_abnormal_spleen_morphology0.82743746
105MP0000858_altered_metastatic_potential0.82469819
106MP0000747_muscle_weakness0.82258111
107MP0000266_abnormal_heart_morphology0.82020444
108MP0003121_genomic_imprinting0.81821366
109MP0001216_abnormal_epidermal_layer0.80106315
110MP0003091_abnormal_cell_migration0.79724934
111MP0004087_abnormal_muscle_fiber0.79201876
112MP0003890_abnormal_embryonic-extraembry0.79047768
113MP0009931_abnormal_skin_appearance0.77056096
114MP0001784_abnormal_fluid_regulation0.76825508
115MP0006054_spinal_hemorrhage0.76775249
116MP0001243_abnormal_dermal_layer0.75721743
117MP0003221_abnormal_cardiomyocyte_apopto0.74500588
118MP0001346_abnormal_lacrimal_gland0.74102751
119MP0002249_abnormal_larynx_morphology0.73482870
120MP0003937_abnormal_limbs/digits/tail_de0.73007680
121MP0003315_abnormal_perineum_morphology0.72280842
122MP0002166_altered_tumor_susceptibility0.72180657
123MP0001853_heart_inflammation0.72140319
124MP0000759_abnormal_skeletal_muscle0.72061886
125MP0002163_abnormal_gland_morphology0.71758693
126MP0003448_altered_tumor_morphology0.71127529
127MP0002060_abnormal_skin_morphology0.70289164
128MP0002429_abnormal_blood_cell0.67770067
129MP0002405_respiratory_system_inflammati0.66835388
130MP0003861_abnormal_nervous_system0.66068692
131MP0002796_impaired_skin_barrier0.65563367
132MP0001286_abnormal_eye_development0.65260411

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)3.49225236
2Selective tooth agenesis (HP:0001592)3.07868157
3Ulnar bowing (HP:0003031)3.04754738
4Hyperacusis (HP:0010780)3.04695767
5Disproportionate tall stature (HP:0001519)2.85522785
6Increased density of long bones (HP:0006392)2.78984135
7Abnormality of the astrocytes (HP:0100707)2.75255705
8Astrocytoma (HP:0009592)2.75255705
9Reticulocytopenia (HP:0001896)2.75049502
10Progressive muscle weakness (HP:0003323)2.70275284
11Pseudobulbar signs (HP:0002200)2.68993207
12Broad distal phalanx of finger (HP:0009836)2.67869907
13Shallow orbits (HP:0000586)2.67316345
14Renal duplication (HP:0000075)2.67194396
15Basal cell carcinoma (HP:0002671)2.66193469
16Dysmetric saccades (HP:0000641)2.64386158
17Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.62428080
18Short 4th metacarpal (HP:0010044)2.62428080
19Cerebral aneurysm (HP:0004944)2.54000109
20Protrusio acetabuli (HP:0003179)2.49075466
21Ankyloglossia (HP:0010296)2.46461724
22Centrally nucleated skeletal muscle fibers (HP:0003687)2.46084400
23Deep palmar crease (HP:0006191)2.43936735
24Increased nuchal translucency (HP:0010880)2.43134922
25Long palpebral fissure (HP:0000637)2.41446197
26Neoplasm of striated muscle (HP:0009728)2.39326854
27Distal lower limb amyotrophy (HP:0008944)2.37885388
28Abnormality of reticulocytes (HP:0004312)2.35968809
29Abnormality of cells of the erythroid lineage (HP:0012130)2.34003807
30Rib fusion (HP:0000902)2.32028106
31Genu recurvatum (HP:0002816)2.30232140
32Progressive external ophthalmoplegia (HP:0000590)2.28791547
33Rhabdomyosarcoma (HP:0002859)2.27640602
34Deviation of the thumb (HP:0009603)2.26487507
35Multiple enchondromatosis (HP:0005701)2.25347164
36Proximal placement of thumb (HP:0009623)2.23477592
37Abnormality of oral frenula (HP:0000190)2.15306815
38Trismus (HP:0000211)2.15078754
39Reticulocytosis (HP:0001923)2.13985920
40Missing ribs (HP:0000921)2.12343696
41Abnormality of the 4th metacarpal (HP:0010012)2.11966835
42Renovascular hypertension (HP:0100817)2.10819773
43Medulloblastoma (HP:0002885)2.10742593
44Skin tags (HP:0010609)2.09090332
45Adenoma sebaceum (HP:0009720)2.08772824
46Angiofibromas (HP:0010615)2.08772824
47Abnormal number of erythroid precursors (HP:0012131)2.07717499
48Premature rupture of membranes (HP:0001788)2.07350470
49Abnormal gallbladder physiology (HP:0012438)2.07010506
50Cholecystitis (HP:0001082)2.07010506
51Broad face (HP:0000283)2.05630170
52Heterotopia (HP:0002282)2.05458524
53Abnormality of the peritoneum (HP:0002585)2.02364244
54Asymmetry of the thorax (HP:0001555)2.00780541
55Broad palm (HP:0001169)1.99948288
56Large earlobe (HP:0009748)1.99692959
57High pitched voice (HP:0001620)1.99649173
58Increased connective tissue (HP:0009025)1.98573169
59Abnormality of the thoracic spine (HP:0100711)1.97521012
60Breast hypoplasia (HP:0003187)1.97043081
61Abnormality of the distal phalanx of the thumb (HP:0009617)1.96261788
62Flared metaphyses (HP:0003015)1.96039586
63Atresia of the external auditory canal (HP:0000413)1.95978860
64Short 5th finger (HP:0009237)1.95765432
65Supernumerary ribs (HP:0005815)1.94676740
66Abnormal number of incisors (HP:0011064)1.94331815
67Ankle contracture (HP:0006466)1.93844975
68Preauricular skin tag (HP:0000384)1.93327949
69Chromosomal breakage induced by crosslinking agents (HP:0003221)1.93226556
70Sparse lateral eyebrow (HP:0005338)1.93089310
71Dislocated radial head (HP:0003083)1.90693365
72Short humerus (HP:0005792)1.90468732
73Glioma (HP:0009733)1.90354686
74Overriding aorta (HP:0002623)1.90133534
75Aplasia/hypoplasia of the humerus (HP:0006507)1.89986540
7611 pairs of ribs (HP:0000878)1.89826539
77Microvesicular hepatic steatosis (HP:0001414)1.89682993
78Mitral valve prolapse (HP:0001634)1.88926278
79Abnormality of the fingertips (HP:0001211)1.88523582
80Flat acetabular roof (HP:0003180)1.87647871
81Elfin facies (HP:0004428)1.87374391
82Achilles tendon contracture (HP:0001771)1.87133014
83Pointed chin (HP:0000307)1.87090185
84Neoplasm of the oral cavity (HP:0100649)1.85189917
85Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.85059263
86Bowel diverticulosis (HP:0005222)1.85001770
87Insomnia (HP:0100785)1.83521837
88Hallux valgus (HP:0001822)1.83218238
89Obstructive sleep apnea (HP:0002870)1.82143558
90Fibroma (HP:0010614)1.81975523
91Ragged-red muscle fibers (HP:0003200)1.81701423
92Bladder diverticulum (HP:0000015)1.81156688
93Squamous cell carcinoma (HP:0002860)1.79992867
94Colitis (HP:0002583)1.79485091
95Syringomyelia (HP:0003396)1.79316151
96Spinal cord lesions (HP:0100561)1.79316151
97Long eyelashes (HP:0000527)1.78941514
98Deviation of the hallux (HP:0010051)1.78629378
99Turricephaly (HP:0000262)1.78577883
100Cafe-au-lait spot (HP:0000957)1.77947876
101Rectal prolapse (HP:0002035)1.77100091
102Patellar aplasia (HP:0006443)1.76862030
103Truncus arteriosus (HP:0001660)1.76685356
104High anterior hairline (HP:0009890)1.76443075
105Fibrous tissue neoplasm (HP:0012316)1.76328983
106Pallor (HP:0000980)1.76225835
107Vertebral fusion (HP:0002948)1.75875658
108Abnormal platelet volume (HP:0011876)1.74804194
109Persistence of primary teeth (HP:0006335)1.74466940
110Overlapping toe (HP:0001845)1.74444790
111Abnormality of the salivary glands (HP:0010286)1.74414095
112Gastrointestinal carcinoma (HP:0002672)1.74148863
113Malignant gastrointestinal tract tumors (HP:0006749)1.74148863
114Biconcave vertebral bodies (HP:0004586)1.73551354
115Patellar dislocation (HP:0002999)1.73107047
116Bowed forearm bones (HP:0003956)1.72776236
117Bowing of the arm (HP:0006488)1.72776236
118Aplasia/Hypoplasia of the sacrum (HP:0008517)1.72738989
119Premature skin wrinkling (HP:0100678)1.72207060
120Hypertensive crisis (HP:0100735)1.72187870
121Nonimmune hydrops fetalis (HP:0001790)1.71883588
122Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.71713332
123Aplasia/Hypoplasia of the patella (HP:0006498)1.71559396
124Metaphyseal cupping (HP:0003021)1.71538323
125Slender build (HP:0001533)1.71109225
126Papilloma (HP:0012740)1.71104264
127Verrucae (HP:0200043)1.71104264
128Increased mean platelet volume (HP:0011877)1.70505158
129Abnormality of the lower motor neuron (HP:0002366)1.70419356
130Esophageal atresia (HP:0002032)1.70237131
131Abnormality of the radial head (HP:0003995)1.69903315
132Abnormality of the Achilles tendon (HP:0005109)1.69867135
133Vertebral compression fractures (HP:0002953)1.69665715
134Chromsome breakage (HP:0040012)1.69497689
135Segmental peripheral demyelination/remyelination (HP:0003481)1.69153715
136Abnormality of the calcaneus (HP:0008364)1.68963701
137Upper limb amyotrophy (HP:0009129)1.68744071
138Distal upper limb amyotrophy (HP:0007149)1.68744071
139Short phalanx of the thumb (HP:0009660)1.67807962
140Lower limb amyotrophy (HP:0007210)1.67566774
141Supernumerary bones of the axial skeleton (HP:0009144)1.66984693
142Myopathic facies (HP:0002058)1.66337164
143Absent thumb (HP:0009777)1.65787276
144Hypochromic anemia (HP:0001931)1.65450923
145Hand muscle atrophy (HP:0009130)1.65429226
146Thin ribs (HP:0000883)1.65376709
147Seborrheic dermatitis (HP:0001051)1.65303274
148Cellulitis (HP:0100658)1.64735056
149Lymphangioma (HP:0100764)1.63985736
150Urethral obstruction (HP:0000796)1.63963883
151Facial hemangioma (HP:0000329)1.63552369
152Polygenic inheritance (HP:0010982)1.63347705
153Difficulty climbing stairs (HP:0003551)1.63306771
154Vertebral clefting (HP:0008428)1.63236416
155Bowel incontinence (HP:0002607)1.61759931
156Spina bifida occulta (HP:0003298)1.61608513
157Thoracic kyphosis (HP:0002942)1.60577043
158Thin bony cortex (HP:0002753)1.59069686
159Septate vagina (HP:0001153)1.55515725
160Skull defect (HP:0001362)1.54830486
161Arnold-Chiari malformation (HP:0002308)1.54382510
162Abnormal large intestine physiology (HP:0012700)1.54213559
163Birth length less than 3rd percentile (HP:0003561)1.53608578
164Gastrointestinal stroma tumor (HP:0100723)1.53268338
165Abnormal vertebral ossification (HP:0100569)1.52412904
166Thrombocytosis (HP:0001894)1.52141948
167Slow saccadic eye movements (HP:0000514)1.50586622

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K104.39401809
2SMG14.33655946
3EEF2K4.02628545
4CDK123.71554040
5TRIB33.41830571
6PKN23.32999850
7PRPF4B3.18757086
8ICK2.99923600
9CDC72.61014913
10IRAK32.47972889
11NEK22.39020978
12TLK12.21129856
13RPS6KB21.86703951
14STK101.82268545
15MAP4K11.81284095
16ERN11.76985990
17BMX1.73975888
18TTN1.47721103
19ALK1.44673932
20CDK41.44531337
21CDK71.42023053
22GRK61.41791960
23LRRK21.41710020
24PTK61.38215793
25PDGFRA1.33307787
26MTOR1.31406495
27TYRO31.28947575
28TTK1.24975318
29PASK1.23129945
30PAK41.21978504
31MAP3K81.21581181
32TAOK21.21016384
33DDR21.19638593
34MAP3K131.19130478
35TESK21.16208706
36SIK11.14420424
37BUB11.13917797
38CDK61.13761174
39PAK21.08686965
40NEK11.00330394
41STK40.99496723
42BRAF0.98603614
43PIM10.95228701
44CHEK10.95066127
45VRK20.95013141
46EPHA20.94362479
47KSR20.92779694
48BRD40.91468565
49EPHB10.90759204
50WEE10.90196401
51ATR0.89165944
52FLT30.86886132
53ILK0.83743366
54CAMK1D0.83683435
55PLK10.83048513
56DYRK1B0.82655467
57TAF10.81635041
58CSK0.81321435
59AURKB0.80474489
60SIK20.78497334
61NME20.77727080
62CHEK20.76707263
63MST1R0.76605352
64CDC42BPA0.76451541
65CDK20.76068556
66MAP3K110.75836260
67DYRK30.74738477
68ARAF0.73070466
69CLK10.72996575
70RPS6KA40.72470222
71MAP3K140.72373440
72UHMK10.71486323
73SRPK10.70150034
74STK30.69711917
75MKNK10.69645426
76MARK20.69588831
77RIPK40.68692050
78EPHB20.68379121
79AKT20.67619778
80IRAK40.67404091
81SCYL20.67246361
82TESK10.66161059
83IRAK20.63228092
84ATM0.62953387
85PAK10.62702983
86AURKA0.61810802
87RIPK10.61681478
88MAPK110.61344913
89RPS6KA10.59994786
90MAP3K10.59600612
91TAOK10.58695052
92LATS10.58539742
93RPS6KC10.58000512
94RPS6KL10.58000512
95KDR0.57830762
96PDPK10.54914043
97MKNK20.54350614
98MAP3K90.52772706
99BTK0.52714091
100TGFBR10.52540086
101CSF1R0.52160977
102RPS6KA60.51625699
103RPS6KA20.51056165
104PDGFRB0.50858905
105PRKD20.50543904
106FGFR40.49790538
107DMPK0.49307253
108PTK20.48073069
109CAMK1G0.47942246
110ZAP700.47917965
111CDK80.47671543
112CDK10.47437483
113CHUK0.47355466
114MAP2K20.45963496
115MAP2K30.45048494
116LATS20.43376765
117CSNK1D0.43031915
118MET0.42454702
119CDK90.41935348
120FGR0.41407721
121FGFR10.40983420
122BLK0.40742477
123HIPK20.38909255
124MAPKAPK20.38398776
125RAF10.37898118
126JAK30.37066973
127AKT10.35359464
128MELK0.35327474
129TSSK60.29840342
130BRSK10.29007442

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.27639048
2Spliceosome_Homo sapiens_hsa030402.90577110
3Mismatch repair_Homo sapiens_hsa034302.72736460
4One carbon pool by folate_Homo sapiens_hsa006702.68932726
5Ribosome_Homo sapiens_hsa030102.64037967
6RNA transport_Homo sapiens_hsa030132.38116276
7Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.31753034
8Base excision repair_Homo sapiens_hsa034102.30332383
9* mRNA surveillance pathway_Homo sapiens_hsa030152.14914469
10Cell cycle_Homo sapiens_hsa041102.13281601
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.97794046
12Chronic myeloid leukemia_Homo sapiens_hsa052201.80349120
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.70845780
14Lysine degradation_Homo sapiens_hsa003101.69460509
15Systemic lupus erythematosus_Homo sapiens_hsa053221.60836296
16Nucleotide excision repair_Homo sapiens_hsa034201.60307747
17Bladder cancer_Homo sapiens_hsa052191.59204604
18Notch signaling pathway_Homo sapiens_hsa043301.57968474
19Fructose and mannose metabolism_Homo sapiens_hsa000511.54104624
20MicroRNAs in cancer_Homo sapiens_hsa052061.53744194
21Viral carcinogenesis_Homo sapiens_hsa052031.52142388
22Homologous recombination_Homo sapiens_hsa034401.45717080
23Small cell lung cancer_Homo sapiens_hsa052221.44931308
24Basal cell carcinoma_Homo sapiens_hsa052171.44729331
25p53 signaling pathway_Homo sapiens_hsa041151.40772768
26Other glycan degradation_Homo sapiens_hsa005111.35723780
27Acute myeloid leukemia_Homo sapiens_hsa052211.35010835
28Sulfur relay system_Homo sapiens_hsa041221.32661979
29Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.31059135
30Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.28990797
31HTLV-I infection_Homo sapiens_hsa051661.28579263
32mTOR signaling pathway_Homo sapiens_hsa041501.22115939
33Hippo signaling pathway_Homo sapiens_hsa043901.18822255
34Transcriptional misregulation in cancer_Homo sapiens_hsa052021.18605713
35Central carbon metabolism in cancer_Homo sapiens_hsa052301.17052462
36Fanconi anemia pathway_Homo sapiens_hsa034601.17008278
37Cyanoamino acid metabolism_Homo sapiens_hsa004601.13972213
38Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.12980783
39Proteoglycans in cancer_Homo sapiens_hsa052051.12618924
40Non-small cell lung cancer_Homo sapiens_hsa052231.11460149
41Prion diseases_Homo sapiens_hsa050201.11443907
42Adherens junction_Homo sapiens_hsa045201.11206105
43Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.10775266
44Primary immunodeficiency_Homo sapiens_hsa053401.04759442
45Thyroid cancer_Homo sapiens_hsa052161.03197128
46Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.02908300
47Selenocompound metabolism_Homo sapiens_hsa004501.02794443
48Viral myocarditis_Homo sapiens_hsa054161.02636180
49Biosynthesis of amino acids_Homo sapiens_hsa012301.02562389
50RNA degradation_Homo sapiens_hsa030181.02289101
51B cell receptor signaling pathway_Homo sapiens_hsa046621.01749828
52Colorectal cancer_Homo sapiens_hsa052101.01645988
53Antigen processing and presentation_Homo sapiens_hsa046121.00796546
54Galactose metabolism_Homo sapiens_hsa000520.99309065
55Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.98357863
56Herpes simplex infection_Homo sapiens_hsa051680.97208376
57Hedgehog signaling pathway_Homo sapiens_hsa043400.93980394
58ErbB signaling pathway_Homo sapiens_hsa040120.92758781
59Apoptosis_Homo sapiens_hsa042100.91354964
60Epstein-Barr virus infection_Homo sapiens_hsa051690.88954104
61Pancreatic cancer_Homo sapiens_hsa052120.86780851
62Focal adhesion_Homo sapiens_hsa045100.86719568
63VEGF signaling pathway_Homo sapiens_hsa043700.85983335
64Endometrial cancer_Homo sapiens_hsa052130.85594500
65Prostate cancer_Homo sapiens_hsa052150.85026204
66Non-homologous end-joining_Homo sapiens_hsa034500.84955082
67Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.78926231
68Hepatitis B_Homo sapiens_hsa051610.77891683
69Pentose phosphate pathway_Homo sapiens_hsa000300.75688498
70Influenza A_Homo sapiens_hsa051640.74513371
71Shigellosis_Homo sapiens_hsa051310.74106960
72AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.73787010
73TGF-beta signaling pathway_Homo sapiens_hsa043500.71901270
74Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.71544167
75Hepatitis C_Homo sapiens_hsa051600.71342544
76Leukocyte transendothelial migration_Homo sapiens_hsa046700.70569628
77T cell receptor signaling pathway_Homo sapiens_hsa046600.69873295
78Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.69869905
79Pathways in cancer_Homo sapiens_hsa052000.69785765
80Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.69586128
81Renal cell carcinoma_Homo sapiens_hsa052110.69278243
82Pyrimidine metabolism_Homo sapiens_hsa002400.65807558
83AMPK signaling pathway_Homo sapiens_hsa041520.65653428
84Choline metabolism in cancer_Homo sapiens_hsa052310.65257400
85Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.64647906
86Tight junction_Homo sapiens_hsa045300.64353897
87HIF-1 signaling pathway_Homo sapiens_hsa040660.63279033
88Regulation of actin cytoskeleton_Homo sapiens_hsa048100.62777714
89Measles_Homo sapiens_hsa051620.60598047
90Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.60552539
91Toll-like receptor signaling pathway_Homo sapiens_hsa046200.60111764
92Prolactin signaling pathway_Homo sapiens_hsa049170.59374138
93Toxoplasmosis_Homo sapiens_hsa051450.57478753
94Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.56825819
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56286610
96Neurotrophin signaling pathway_Homo sapiens_hsa047220.56269843
97Adipocytokine signaling pathway_Homo sapiens_hsa049200.54379612
98Longevity regulating pathway - mammal_Homo sapiens_hsa042110.54343166
99Glioma_Homo sapiens_hsa052140.54215763
100Insulin resistance_Homo sapiens_hsa049310.53927991
101Alcoholism_Homo sapiens_hsa050340.53354971
102Basal transcription factors_Homo sapiens_hsa030220.52756266
103NF-kappa B signaling pathway_Homo sapiens_hsa040640.52508906
104Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.52366543
105Carbon metabolism_Homo sapiens_hsa012000.52270708
106ECM-receptor interaction_Homo sapiens_hsa045120.52115271
107Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.52042511
108Wnt signaling pathway_Homo sapiens_hsa043100.51375088
109Phospholipase D signaling pathway_Homo sapiens_hsa040720.50692851
110TNF signaling pathway_Homo sapiens_hsa046680.49794066
111Legionellosis_Homo sapiens_hsa051340.49777766
112Osteoclast differentiation_Homo sapiens_hsa043800.49593455
113Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.49466181
114RNA polymerase_Homo sapiens_hsa030200.47146619
115GnRH signaling pathway_Homo sapiens_hsa049120.47068457
116PI3K-Akt signaling pathway_Homo sapiens_hsa041510.46603665
117Estrogen signaling pathway_Homo sapiens_hsa049150.46501623
118Oocyte meiosis_Homo sapiens_hsa041140.44477402
119Inositol phosphate metabolism_Homo sapiens_hsa005620.43843949
120Cysteine and methionine metabolism_Homo sapiens_hsa002700.41579011
121Melanoma_Homo sapiens_hsa052180.41335694
122Insulin signaling pathway_Homo sapiens_hsa049100.40901100
1232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.39347148
124FoxO signaling pathway_Homo sapiens_hsa040680.38000856

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