DAZAP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a proline-rich protein which interacts with the deleted in azoospermia (DAZ) and the deleted in azoospermia-like gene through the DAZ-like repeats. This protein also interacts with the transforming growth factor-beta signaling molecule SARA (Smad anchor for receptor activation), eukaryotic initiation factor 4G, and an E3 ubiquitinase that regulates its stability in splicing factor containing nuclear speckles. The encoded protein may function in various biological and pathological processes including spermatogenesis, cell signaling and transcription regulation, formation of stress granules during translation arrest, RNA splicing, and pathogenesis of multiple myeloma. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.64503645
2negative regulation of cell killing (GO:0031342)5.64503645
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.37219626
4antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.37219626
5antigen processing and presentation of endogenous antigen (GO:0019883)5.30251885
6antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.88641762
7positive regulation of gamma-delta T cell activation (GO:0046645)4.74468564
8regulation of B cell receptor signaling pathway (GO:0050855)4.26730782
9neutrophil activation involved in immune response (GO:0002283)4.26073668
10positive thymic T cell selection (GO:0045059)4.01686701
11cellular response to interleukin-15 (GO:0071350)3.93727366
12leukocyte aggregation (GO:0070486)3.93343778
13positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.88977446
14response to interleukin-15 (GO:0070672)3.82933195
15Arp2/3 complex-mediated actin nucleation (GO:0034314)3.79079234
16detection of bacterium (GO:0016045)3.79011760
17immunoglobulin mediated immune response (GO:0016064)3.77328286
18regulation of regulatory T cell differentiation (GO:0045589)3.70186607
19positive regulation of B cell differentiation (GO:0045579)3.68166871
20negative regulation of lymphocyte mediated immunity (GO:0002707)3.62877412
21positive T cell selection (GO:0043368)3.62617130
22positive regulation of T cell mediated cytotoxicity (GO:0001916)3.53465588
23regulation of T cell mediated cytotoxicity (GO:0001914)3.50621476
24regulation of B cell differentiation (GO:0045577)3.45828746
25positive regulation by symbiont of host defense response (GO:0052509)3.43229733
26modulation by symbiont of host defense response (GO:0052031)3.43229733
27modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.43229733
28modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.43229733
29positive regulation by organism of defense response of other organism involved in symbiotic interact3.43229733
30modulation by symbiont of host immune response (GO:0052553)3.43229733
31regulation of interferon-beta biosynthetic process (GO:0045357)3.42897217
32antigen processing and presentation via MHC class Ib (GO:0002475)3.39323289
33regulation of interleukin-12 biosynthetic process (GO:0045075)3.39097399
34negative regulation of interleukin-12 production (GO:0032695)3.39070389
35negative regulation of leukocyte mediated immunity (GO:0002704)3.38231396
36mast cell activation (GO:0045576)3.37060541
37production of molecular mediator involved in inflammatory response (GO:0002532)3.36337095
38T cell selection (GO:0045058)3.35891949
39myeloid dendritic cell activation (GO:0001773)3.33921006
40regulation of gamma-delta T cell differentiation (GO:0045586)3.31628475
41regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.30507230
42regulation of natural killer cell mediated immunity (GO:0002715)3.30507230
43regulation of tolerance induction (GO:0002643)3.30428646
44response to interferon-beta (GO:0035456)3.29410944
45negative regulation of phagocytosis (GO:0050765)3.27525799
46regulation of gamma-delta T cell activation (GO:0046643)3.27227881
47negative regulation of T cell mediated immunity (GO:0002710)3.27175061
48respiratory burst (GO:0045730)3.27015193
49thymic T cell selection (GO:0045061)3.25959451
50defense response to protozoan (GO:0042832)3.17773816
51positive regulation of tolerance induction (GO:0002645)3.17528973
52response to protozoan (GO:0001562)3.17072587
53response to peptidoglycan (GO:0032494)3.14938234
54regulation of mast cell degranulation (GO:0043304)3.14696588
55T cell migration (GO:0072678)3.14694993
56cytidine deamination (GO:0009972)3.14015964
57cytidine metabolic process (GO:0046087)3.14015964
58cytidine catabolic process (GO:0006216)3.14015964
59positive regulation of interferon-alpha production (GO:0032727)3.13921039
60regulation of leukocyte mediated cytotoxicity (GO:0001910)3.12573525
61neutrophil activation (GO:0042119)3.09240181
62positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.09058212
63cellular extravasation (GO:0045123)3.08658107
64response to type I interferon (GO:0034340)3.06400145
65detection of external biotic stimulus (GO:0098581)3.05959861
66cellular response to type I interferon (GO:0071357)3.05392635
67type I interferon signaling pathway (GO:0060337)3.05392635
68antigen receptor-mediated signaling pathway (GO:0050851)3.05074257
69B cell mediated immunity (GO:0019724)3.04297335
70cellular response to zinc ion (GO:0071294)3.03360531
71regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.01184914
72regulation of RIG-I signaling pathway (GO:0039535)3.00368312
73T cell receptor signaling pathway (GO:0050852)3.00054057
74positive regulation of mast cell activation (GO:0033005)2.99870615
75regulation of interferon-alpha production (GO:0032647)2.99414336
76hepatocyte apoptotic process (GO:0097284)2.98996416
77definitive hemopoiesis (GO:0060216)2.98118896
78B cell receptor signaling pathway (GO:0050853)2.97290265
79positive regulation of antigen processing and presentation (GO:0002579)2.96393287
80negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.95616234
81T-helper 1 type immune response (GO:0042088)2.94085303
82positive regulation of granulocyte differentiation (GO:0030854)2.93859154
83granulocyte activation (GO:0036230)2.91123450
84microglial cell activation (GO:0001774)2.90537253
85myeloid cell activation involved in immune response (GO:0002275)2.89960676
86megakaryocyte development (GO:0035855)2.88913541
87myeloid dendritic cell differentiation (GO:0043011)2.88155447
88pyrimidine ribonucleoside catabolic process (GO:0046133)2.87279401
89regulation of necroptotic process (GO:0060544)2.86674594
90regulation of mast cell activation involved in immune response (GO:0033006)2.86445733
91regulation of dendritic cell antigen processing and presentation (GO:0002604)2.85903662
92regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.84797718
93positive regulation of alpha-beta T cell proliferation (GO:0046641)2.84446038
94negative regulation of innate immune response (GO:0045824)2.84080156
95NIK/NF-kappaB signaling (GO:0038061)2.83823324
96regulation of cell killing (GO:0031341)2.83590704
97actin nucleation (GO:0045010)2.82593488
98positive regulation of macrophage differentiation (GO:0045651)2.81340682
99response to muramyl dipeptide (GO:0032495)2.80895510
100cellular response to exogenous dsRNA (GO:0071360)2.80466029
101regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.79343352
102negative thymic T cell selection (GO:0045060)2.79252513
103regulation of alpha-beta T cell proliferation (GO:0046640)2.79143306
104response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.78956206
105cellular response to interferon-beta (GO:0035458)2.78917493
106interferon-gamma-mediated signaling pathway (GO:0060333)2.78138044
107activated T cell proliferation (GO:0050798)2.77746881
108interferon-gamma production (GO:0032609)2.77181674
109positive regulation of cell killing (GO:0031343)2.76465512
110positive regulation of natural killer cell mediated immunity (GO:0002717)2.76015150
111ribosomal small subunit assembly (GO:0000028)2.72439453
112positive regulation of lamellipodium assembly (GO:0010592)2.72279019
113detection of other organism (GO:0098543)2.71451468
114pinocytosis (GO:0006907)2.70856512
115positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.70393170
116negative T cell selection (GO:0043383)2.69073411
117dendritic cell chemotaxis (GO:0002407)2.68911985
118necroptotic process (GO:0070266)2.66974618
119leukocyte cell-cell adhesion (GO:0007159)2.64791662
120lipopolysaccharide-mediated signaling pathway (GO:0031663)2.63090169
121chaperone mediated protein folding requiring cofactor (GO:0051085)2.60946875
122myeloid leukocyte activation (GO:0002274)2.59568856
123positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.59455400
124leukocyte degranulation (GO:0043299)2.58888246
125dendritic cell migration (GO:0036336)2.57612065
126negative regulation of erythrocyte differentiation (GO:0045647)2.52848332
127regulation of response to interferon-gamma (GO:0060330)2.52810407
128macrophage activation involved in immune response (GO:0002281)2.52601386
129dendritic cell differentiation (GO:0097028)2.51032338
130regulation of mast cell activation (GO:0033003)2.50298864
131positive regulation of natural killer cell differentiation (GO:0032825)2.48978292
132regulation of T cell tolerance induction (GO:0002664)2.48734673
133response to interferon-alpha (GO:0035455)2.46389914
134natural killer cell activation (GO:0030101)2.45845081
135positive regulation of interferon-beta production (GO:0032728)2.45831423
136signal peptide processing (GO:0006465)2.43958099
137regulation of antigen processing and presentation (GO:0002577)2.43780648
138tolerance induction (GO:0002507)2.43230815
139negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.43002420
140regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.42834383
141regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.41501259
142response to host immune response (GO:0052572)2.41482578

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.93108821
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.05238355
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.98225560
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.74794420
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.72263556
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.53848374
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.52044412
8* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.97847174
9SCL_19346495_ChIP-Seq_HPC-7_Human2.91676284
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.81323814
11MYB_21317192_ChIP-Seq_ERMYB_Mouse2.80478887
12SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.74211176
13IRF8_27001747_Chip-Seq_BMDM_Mouse2.72383611
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.65244264
15RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.58622606
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.53973807
17SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.49934674
18STAT4_19710469_ChIP-ChIP_TH1__Mouse2.44856814
19SPI1_23547873_ChIP-Seq_NB4_Human2.36918104
20E2F7_22180533_ChIP-Seq_HELA_Human2.35536510
21MYB_26560356_Chip-Seq_TH2_Human2.24445891
22FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.21351914
23STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.19702275
24NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.12066630
25RUNX_20019798_ChIP-Seq_JUKART_Human2.10554856
26ELF1_17652178_ChIP-ChIP_JURKAT_Human2.08753118
27MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.90963172
28MAF_26560356_Chip-Seq_TH1_Human1.90800253
29RUNX1_22412390_ChIP-Seq_EML_Mouse1.89527819
30VDR_21846776_ChIP-Seq_THP-1_Human1.88020429
31ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.87643091
32* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.86637498
33* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.82385481
34RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.82021973
35EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.77702057
36VDR_24763502_ChIP-Seq_THP-1_Human1.77178997
37MYC_22102868_ChIP-Seq_BL_Human1.75956463
38MYB_26560356_Chip-Seq_TH1_Human1.75190133
39TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.74219924
40LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.74206069
41GATA1_22025678_ChIP-Seq_K562_Human1.74093727
42STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.71472206
43HOXB4_20404135_ChIP-ChIP_EML_Mouse1.70044508
44LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.68641638
45* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.59985408
46CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.55599014
47GATA1_22383799_ChIP-Seq_G1ME_Mouse1.53937449
48GATA2_22383799_ChIP-Seq_G1ME_Mouse1.53903045
49ERG_20887958_ChIP-Seq_HPC-7_Mouse1.53123574
50UTX_26944678_Chip-Seq_JUKART_Human1.52309964
51Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.51769298
52GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.47121124
53NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.43269784
54SMAD_19615063_ChIP-ChIP_OVARY_Human1.40290644
55E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.39305701
56GATA3_27048872_Chip-Seq_THYMUS_Human1.38867563
57* SPI1_23127762_ChIP-Seq_K562_Human1.37569087
58NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.37235849
59PU_27001747_Chip-Seq_BMDM_Mouse1.36093555
60CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.30980460
61CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.30238374
62BCL6_27268052_Chip-Seq_Bcells_Human1.25685862
63STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.25339409
64GATA2_21666600_ChIP-Seq_HMVEC_Human1.23202919
65VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.22868370
66TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.21917686
67SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21312113
68* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.20868692
69NOTCH1_21737748_ChIP-Seq_TLL_Human1.19460697
70* TCF7_22412390_ChIP-Seq_EML_Mouse1.18212371
71GATA1_19941827_ChIP-Seq_MEL_Mouse1.17694964
72TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.17434199
73CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14051002
74GATA3_26560356_Chip-Seq_TH2_Human1.13931295
75GABP_17652178_ChIP-ChIP_JURKAT_Human1.13383077
76SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.12841794
77GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12281279
78MAF_26560356_Chip-Seq_TH2_Human1.08627732
79CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07789134
80BCOR_27268052_Chip-Seq_Bcells_Human1.06774619
81PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06708296
82VDR_23849224_ChIP-Seq_CD4+_Human1.05839685
83SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05392716
84FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.05236001
85SRF_21415370_ChIP-Seq_HL-1_Mouse1.04566118
86PU.1_20513432_ChIP-Seq_Bcells_Mouse1.01590300
87VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.01500131
88STAT1_20625510_ChIP-Seq_HELA_Human0.99148394
89* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98491336
90ELF1_20517297_ChIP-Seq_JURKAT_Human0.98060152
91PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96819797
92EST1_17652178_ChIP-ChIP_JURKAT_Human0.96731453
93P300_27268052_Chip-Seq_Bcells_Human0.93583656
94KDM2B_26808549_Chip-Seq_SUP-B15_Human0.93171324
95FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.93018594
96FOXP3_21729870_ChIP-Seq_TREG_Human0.92478563
97ELK3_25401928_ChIP-Seq_HUVEC_Human0.90248070
98STAT6_21828071_ChIP-Seq_BEAS2B_Human0.90159111
99ELK1_19687146_ChIP-ChIP_HELA_Human0.89227787
100KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.88549645
101THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.87422980
102PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.87203226
103PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.86703743
104CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.85820454
105TFEB_21752829_ChIP-Seq_HELA_Human0.85262499
106* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85187241
107KDM2B_26808549_Chip-Seq_DND41_Human0.85011248
108KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.84520614
109RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.83676833
110CIITA_25753668_ChIP-Seq_RAJI_Human0.82099681
111SPI1_20517297_ChIP-Seq_HL60_Human0.81888967
112GATA2_19941826_ChIP-Seq_K562_Human0.81596180
113IKZF1_21737484_ChIP-ChIP_HCT116_Human0.80743864
114CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.80565652
115NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.79874922
116RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.79463803
117GATA1_19941826_ChIP-Seq_K562_Human0.79446276
118RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79263522
119KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.79171720
120VDR_24787735_ChIP-Seq_THP-1_Human0.77812375
121GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77700677
122CREB1_15753290_ChIP-ChIP_HEK293T_Human0.75907478
123EGR1_23403033_ChIP-Seq_LIVER_Mouse0.75838777
124* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.74380850

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.19502809
2MP0009785_altered_susceptibility_to3.33561711
3MP0005671_abnormal_response_to3.03784446
4MP0003724_increased_susceptibility_to2.91267921
5MP0003436_decreased_susceptibility_to2.89475231
6MP0000685_abnormal_immune_system2.89341597
7MP0002148_abnormal_hypersensitivity_rea2.80355825
8MP0005000_abnormal_immune_tolerance2.69911026
9MP0005025_abnormal_response_to2.68527035
10MP0002419_abnormal_innate_immunity2.64549954
11MP0001800_abnormal_humoral_immune2.58433816
12MP0002452_abnormal_antigen_presenting2.52660222
13MP0001790_abnormal_immune_system2.50973325
14MP0005387_immune_system_phenotype2.50973325
15MP0002396_abnormal_hematopoietic_system2.45314298
16MP0002723_abnormal_immune_serum2.38283656
17MP0002420_abnormal_adaptive_immunity2.37296616
18MP0001819_abnormal_immune_cell2.36105869
19MP0003763_abnormal_thymus_physiology2.30109356
20MP0001853_heart_inflammation2.29459029
21MP0005464_abnormal_platelet_physiology2.19302095
22MP0010155_abnormal_intestine_physiology2.10489643
23MP0002398_abnormal_bone_marrow2.08380042
24MP0006082_CNS_inflammation2.07864302
25MP0002166_altered_tumor_susceptibility1.99639572
26MP0002405_respiratory_system_inflammati1.99155457
27MP0006054_spinal_hemorrhage1.95152165
28MP0000716_abnormal_immune_system1.92388930
29MP0009333_abnormal_splenocyte_physiolog1.90324582
30MP0001873_stomach_inflammation1.88491292
31MP0005058_abnormal_lysosome_morphology1.87984690
32MP0005397_hematopoietic_system_phenotyp1.85908528
33MP0001545_abnormal_hematopoietic_system1.85908528
34MP0001845_abnormal_inflammatory_respons1.80084277
35MP0000465_gastrointestinal_hemorrhage1.78521158
36MP0000689_abnormal_spleen_morphology1.77634735
37MP0002006_tumorigenesis1.75260348
38MP0000343_altered_response_to1.72169868
39MP0003300_gastrointestinal_ulcer1.69927340
40MP0004808_abnormal_hematopoietic_stem1.69133232
41MP0002722_abnormal_immune_system1.68388051
42MP0002429_abnormal_blood_cell1.68096151
43MP0001533_abnormal_skeleton_physiology1.65309998
44MP0003303_peritoneal_inflammation1.64278326
45MP0004947_skin_inflammation1.60903370
46MP0000490_abnormal_crypts_of1.57916692
47MP0008469_abnormal_protein_level1.46868584
48MP0009278_abnormal_bone_marrow1.45941754
49MP0003191_abnormal_cellular_cholesterol1.43082206
50MP0003186_abnormal_redox_activity1.40962936
51MP0009764_decreased_sensitivity_to1.38611749
52MP0005310_abnormal_salivary_gland1.36804190
53MP0003656_abnormal_erythrocyte_physiolo1.36651466
54MP0002933_joint_inflammation1.33788036
55MP0003866_abnormal_defecation1.30810340
56MP0000858_altered_metastatic_potential1.29701006
57MP0002138_abnormal_hepatobiliary_system1.28645476
58MP0004147_increased_porphyrin_level1.22742607
59MP0004381_abnormal_hair_follicle1.20464334
60MP0000703_abnormal_thymus_morphology1.19341554
61MP0008260_abnormal_autophagy1.14383933
62MP0002132_abnormal_respiratory_system1.13692422
63MP0003183_abnormal_peptide_metabolism1.13269840
64MP0003806_abnormal_nucleotide_metabolis1.13027405
65MP0004510_myositis1.12522233
66MP0005174_abnormal_tail_pigmentation1.06908414
67MP0003075_altered_response_to1.04296287
68MP0002277_abnormal_respiratory_mucosa1.03636840
69MP0003448_altered_tumor_morphology1.01332222
70MP0005075_abnormal_melanosome_morpholog1.00910786
71MP0004782_abnormal_surfactant_physiolog1.00297025
72MP0003172_abnormal_lysosome_physiology0.98334016
73MP0003828_pulmonary_edema0.96752044
74MP0001851_eye_inflammation0.92710032
75MP0008004_abnormal_stomach_pH0.91133945
76MP0002019_abnormal_tumor_incidence0.90826033
77MP0005166_decreased_susceptibility_to0.89992787
78MP0009840_abnormal_foam_cell0.88654068
79MP0000604_amyloidosis0.88154901
80MP0002998_abnormal_bone_remodeling0.86890539
81MP0001663_abnormal_digestive_system0.85935881
82MP0005167_abnormal_blood-brain_barrier0.82751930
83MP0009763_increased_sensitivity_to0.81965764
84MP0000249_abnormal_blood_vessel0.81891897
85MP0003045_fibrosis0.81666890
86MP0003279_aneurysm0.78665924
87MP0003943_abnormal_hepatobiliary_system0.77298734
88MP0001879_abnormal_lymphatic_vessel0.77176850
89MP0003690_abnormal_glial_cell0.76336910
90MP0009643_abnormal_urine_homeostasis0.75494822
91MP0002136_abnormal_kidney_physiology0.74966665
92MP0005390_skeleton_phenotype0.74478897
93MP0008875_abnormal_xenobiotic_pharmacok0.74013782
94MP0002009_preneoplasia0.74007758
95MP0001765_abnormal_ion_homeostasis0.73165208
96MP0002877_abnormal_melanocyte_morpholog0.71090821
97MP0003252_abnormal_bile_duct0.69499731
98MP0005451_abnormal_body_composition0.67890351
99MP0008007_abnormal_cellular_replicative0.67065751
100MP0002095_abnormal_skin_pigmentation0.65040585
101MP0005164_abnormal_response_to0.64580949
102MP0005023_abnormal_wound_healing0.64457815
103MP0003795_abnormal_bone_structure0.64424264
104MP0005365_abnormal_bile_salt0.62251502
105MP0000015_abnormal_ear_pigmentation0.62165532
106MP0005584_abnormal_enzyme/coenzyme_acti0.62094926
107MP0005085_abnormal_gallbladder_physiolo0.62038705
108MP0005165_increased_susceptibility_to0.61125557
109MP0003453_abnormal_keratinocyte_physiol0.59688058
110MP0008874_decreased_physiological_sensi0.59045465
111MP0003638_abnormal_response/metabolism_0.58483887
112MP0005319_abnormal_enzyme/_coenzyme0.56776291
113MP0000477_abnormal_intestine_morphology0.56660070
114MP0001191_abnormal_skin_condition0.54310237
115MP0000598_abnormal_liver_morphology0.53763701
116MP0004883_abnormal_blood_vessel0.52977629
117MP0008873_increased_physiological_sensi0.52051020
118MP0000609_abnormal_liver_physiology0.50694581
119MP0009765_abnormal_xenobiotic_induced0.50641231

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.37344100
2Eczematoid dermatitis (HP:0000976)4.82422314
3Recurrent bacterial skin infections (HP:0005406)4.67895786
4Myositis (HP:0100614)4.58272697
5Elevated erythrocyte sedimentation rate (HP:0003565)4.29828520
6IgM deficiency (HP:0002850)4.18326399
7Chronic otitis media (HP:0000389)4.00947023
8Orchitis (HP:0100796)3.74798572
9Abnormality of macrophages (HP:0004311)3.72880749
10Petechiae (HP:0000967)3.70651979
11Vacuolated lymphocytes (HP:0001922)3.68981144
12Recurrent fungal infections (HP:0002841)3.64058767
13Thrombocytosis (HP:0001894)3.57387645
14Pustule (HP:0200039)3.53446284
15Gastrointestinal infarctions (HP:0005244)3.51474956
16Optic neuritis (HP:0100653)3.44822978
17Retrobulbar optic neuritis (HP:0100654)3.44822978
18Recurrent bronchitis (HP:0002837)3.44491956
19Recurrent viral infections (HP:0004429)3.40681618
20Increased IgM level (HP:0003496)3.32603168
21Recurrent gram-negative bacterial infections (HP:0005420)3.30900618
22Recurrent skin infections (HP:0001581)3.28448879
23Cellulitis (HP:0100658)3.26092649
24Agammaglobulinemia (HP:0004432)3.20553895
25Autoimmune thrombocytopenia (HP:0001973)3.20266706
26Meningitis (HP:0001287)3.15078568
27Interstitial pulmonary disease (HP:0006530)3.14817153
28Mediastinal lymphadenopathy (HP:0100721)3.11216110
29Increased neuronal autofluorescent lipopigment (HP:0002074)3.08853606
30Vasculitis (HP:0002633)3.02657359
31Spontaneous hematomas (HP:0007420)3.01533684
32Abnormality of T cell physiology (HP:0011840)3.00328183
33Increased cerebral lipofuscin (HP:0011813)2.93118058
34Gastrointestinal stroma tumor (HP:0100723)2.86646979
35Abnormality of T cells (HP:0002843)2.85312024
36Abnormal delayed hypersensitivity skin test (HP:0002963)2.80078180
37Periodontitis (HP:0000704)2.78339669
38Inflammation of the large intestine (HP:0002037)2.76733949
39Panhypogammaglobulinemia (HP:0003139)2.74501469
40Increased IgE level (HP:0003212)2.73392723
41Chronic mucocutaneous candidiasis (HP:0002728)2.70781844
42Recurrent cutaneous fungal infections (HP:0011370)2.70781844
43Abnormality of the nasal mucosa (HP:0000433)2.70733550
44Abnormality of glycolipid metabolism (HP:0010969)2.70289229
45Abnormality of liposaccharide metabolism (HP:0010968)2.70289229
46Abnormality of glycosphingolipid metabolism (HP:0004343)2.70289229
47Obstructive lung disease (HP:0006536)2.69733606
48Chronic obstructive pulmonary disease (HP:0006510)2.69733606
49Aplastic anemia (HP:0001915)2.69080820
50Prolonged bleeding time (HP:0003010)2.67977494
51IgG deficiency (HP:0004315)2.65846058
52Gastrointestinal inflammation (HP:0004386)2.64861153
53Lymphopenia (HP:0001888)2.58435211
54Osteomyelitis (HP:0002754)2.57045394
55Keratoconjunctivitis sicca (HP:0001097)2.55539411
56Gangrene (HP:0100758)2.54315547
57Colitis (HP:0002583)2.53476716
58Pulmonary embolism (HP:0002204)2.52799233
59Abnormality of T cell number (HP:0011839)2.52216953
60Arterial thrombosis (HP:0004420)2.51943016
61Stomatitis (HP:0010280)2.51623429
62Pulmonary infiltrates (HP:0002113)2.50637143
63Epistaxis (HP:0000421)2.49869339
64Abnormality of cells of the lymphoid lineage (HP:0012140)2.49279355
65Nasal polyposis (HP:0100582)2.49007920
66T lymphocytopenia (HP:0005403)2.40565494
67Anorexia (HP:0002039)2.40039495
68Urticaria (HP:0001025)2.39105317
69Leukocytosis (HP:0001974)2.38388178
70Purpura (HP:0000979)2.37721643
71Joint swelling (HP:0001386)2.35419474
72Encephalitis (HP:0002383)2.34663901
73Abnormality of the prostate (HP:0008775)2.32211776
74Keratoconjunctivitis (HP:0001096)2.32030795
75Abnormality of the pleura (HP:0002103)2.31623866
76Episodic fever (HP:0001954)2.30762461
77Chronic diarrhea (HP:0002028)2.28343057
78Systemic lupus erythematosus (HP:0002725)2.27721201
79Gingivitis (HP:0000230)2.25485167
80Hemoptysis (HP:0002105)2.25113862
81Dysostosis multiplex (HP:0000943)2.23971156
82IgA deficiency (HP:0002720)2.22409321
83Gingival bleeding (HP:0000225)2.19788626
84Abnormality of B cell number (HP:0010975)2.18305390
85B lymphocytopenia (HP:0010976)2.18305390
86Neutropenia (HP:0001875)2.16814282
87Poor head control (HP:0002421)2.16386873
88Amyloidosis (HP:0011034)2.13918785
89Recurrent pneumonia (HP:0006532)2.13818970
90Increased serum ferritin (HP:0003281)2.12757952
91Abnormality of iron homeostasis (HP:0011031)2.12279763
92Recurrent sinusitis (HP:0011108)2.12147835
93Impaired platelet aggregation (HP:0003540)2.11596517
94Abnormal platelet function (HP:0011869)2.11596517
95Skin ulcer (HP:0200042)2.11043672
96Hepatosplenomegaly (HP:0001433)2.10666301
97Basal ganglia calcification (HP:0002135)2.09194617
98Eosinophilia (HP:0001880)2.08556546
99Abnormality of eosinophils (HP:0001879)2.07309565
100Recurrent lower respiratory tract infections (HP:0002783)2.05974835
101Vertigo (HP:0002321)2.05153661
102Hypergammaglobulinemia (HP:0010702)2.04500321
103Skin rash (HP:0000988)2.04215067
104Hematochezia (HP:0002573)2.04038315
105Loss of speech (HP:0002371)2.03619779
106Glomerulopathy (HP:0100820)2.02670575
107Reduced antithrombin III activity (HP:0001976)2.01823424
108Polyneuropathy (HP:0001271)2.01476372
109Granulocytopenia (HP:0001913)2.01368751
110Acute hepatic failure (HP:0006554)2.01289248
111Bronchitis (HP:0012387)2.00209236
112Chest pain (HP:0100749)1.99608474
113Hypochromic anemia (HP:0001931)1.99203015
114Thyroiditis (HP:0100646)1.99075726
115Sepsis (HP:0100806)1.98122224
116Combined immunodeficiency (HP:0005387)1.97689995
117Lymphoma (HP:0002665)1.97470581
118Pulmonary fibrosis (HP:0002206)1.96743409
119Severe combined immunodeficiency (HP:0004430)1.96259458
120Fatigue (HP:0012378)1.96166922
121Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.94302159
122Arthralgia (HP:0002829)1.93960070
123Hypoproteinemia (HP:0003075)1.93862516
124Verrucae (HP:0200043)1.89929735
125Papilloma (HP:0012740)1.89929735
126Autoimmune hemolytic anemia (HP:0001890)1.89258755

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.02783739
2TXK2.98656592
3KIT2.90482991
4MAP3K142.66753115
5TBK12.55887515
6JAK32.45820002
7BTK2.40533420
8IRAK42.39752237
9BLK2.34441549
10ZAP702.27366265
11TEC2.20275613
12IKBKE2.08870719
13TYK22.08044276
14STK102.01820398
15KDR1.99755561
16ERN11.98855107
17TGFBR21.86880294
18MST41.85335876
19PIM21.81353259
20TNK21.68072499
21LRRK21.64367561
22IRAK31.60911567
23CSF1R1.60448442
24IKBKB1.59395141
25NEK91.57727497
26SYK1.52106615
27MAP2K31.50100719
28ITK1.48043853
29MAP3K121.45799449
30EPHB11.38846615
31FLT31.38492302
32TAOK31.37733859
33TIE11.26735942
34MATK1.25956897
35PRPF4B1.25388568
36RPS6KA41.24153680
37LYN1.22896453
38MYLK1.18172443
39TGFBR11.17092572
40LCK1.12551462
41JAK11.11656792
42CSK1.10220365
43CHUK1.09318055
44PIM11.07947453
45ACVR1B1.00765131
46MAPKAPK30.97929085
47BRSK20.97270123
48TRIB30.95818759
49FGR0.95364352
50STK240.95270039
51HCK0.94626518
52PIK3CG0.93542835
53PIK3CA0.93500617
54GRK70.92439550
55NME20.90888334
56CAMKK20.90793250
57CLK10.90138120
58MAP2K20.89779645
59NLK0.89399421
60GRK60.85058496
61MAP3K10.82738273
62TAOK10.80255885
63PDK10.80138216
64TRPM70.79462593
65FGFR40.79294376
66RIPK40.78044937
67SIK30.76960900
68JAK20.74873211
69MAPKAPK50.73222987
70PAK40.71750716
71STK40.70899465
72TAOK20.70690508
73CAMKK10.66636729
74FYN0.66112824
75EIF2AK30.64267383
76NUAK10.63053356
77TESK20.62742268
78MAPKAPK20.61106522
79MAP3K130.61058632
80EEF2K0.59111008
81FGFR30.58353331
82PTK2B0.57882863
83EIF2AK10.57755079
84MAPK70.57685983
85MAP2K60.55916881
86PRKCQ0.55587562
87ILK0.55540812
88CCNB10.55536267
89HIPK20.55026336
90BCKDK0.54060650
91MARK30.53846507
92PRKCD0.53688121
93CDK80.53514386
94MAP3K30.53198475
95VRK10.53089937
96FES0.52467703
97MAPK120.51380610
98MAP3K50.51325001
99PKN20.51243644
100TESK10.50471255
101PRKG20.50373537
102RIPK10.49810192
103ADRBK20.49795948
104PTK60.49442904
105PDPK10.48616650
106MAP3K110.44997014
107YES10.44225211
108STK30.42912140
109RPS6KA60.42521419
110SCYL20.41497014
111IRAK10.40805922
112MAP3K100.40577863
113IRAK20.39744456
114CDK60.38463842
115MAPK40.38338415
116BMPR20.37566602
117TLK10.37439130
118EPHA30.37366166
119DMPK0.35877766
120STK160.34117215
121DAPK10.33684864
122ABL10.32975573
123IGF1R0.32548715
124RPS6KB20.32332907
125PRKD20.31678470
126GRK50.31094252
127PBK0.30563968
128MAP4K20.29253567
129MAPK110.29190085
130DAPK20.28297169
131SIK20.26753888
132NEK60.26751793
133MAPK30.26485595
134MAP3K70.26427667
135PRKD10.22983717
136KSR20.22020728

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.93809540
2Leishmaniasis_Homo sapiens_hsa051402.92819258
3Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.50873363
4Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.47532023
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.40838598
6NF-kappa B signaling pathway_Homo sapiens_hsa040642.37862218
7Legionellosis_Homo sapiens_hsa051342.21908467
8Measles_Homo sapiens_hsa051622.19868273
9Antigen processing and presentation_Homo sapiens_hsa046122.07268949
10Toll-like receptor signaling pathway_Homo sapiens_hsa046202.06538401
11RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.02513425
12B cell receptor signaling pathway_Homo sapiens_hsa046622.02214566
13Osteoclast differentiation_Homo sapiens_hsa043801.99264561
14Allograft rejection_Homo sapiens_hsa053301.97836246
15Hematopoietic cell lineage_Homo sapiens_hsa046401.96862796
16Graft-versus-host disease_Homo sapiens_hsa053321.95664722
17Pertussis_Homo sapiens_hsa051331.80752359
18Other glycan degradation_Homo sapiens_hsa005111.80051071
19NOD-like receptor signaling pathway_Homo sapiens_hsa046211.77468977
20Staphylococcus aureus infection_Homo sapiens_hsa051501.71286777
21Herpes simplex infection_Homo sapiens_hsa051681.69441061
22Shigellosis_Homo sapiens_hsa051311.67306421
23Malaria_Homo sapiens_hsa051441.64492322
24Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.62818049
25Toxoplasmosis_Homo sapiens_hsa051451.59175969
26Tuberculosis_Homo sapiens_hsa051521.55157703
27Jak-STAT signaling pathway_Homo sapiens_hsa046301.47841711
28Influenza A_Homo sapiens_hsa051641.47787567
29DNA replication_Homo sapiens_hsa030301.47544371
30Leukocyte transendothelial migration_Homo sapiens_hsa046701.43486680
31Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.41102571
32Lysosome_Homo sapiens_hsa041421.37385307
33Caffeine metabolism_Homo sapiens_hsa002321.36007127
34Salmonella infection_Homo sapiens_hsa051321.33701774
35Asthma_Homo sapiens_hsa053101.29762954
36Base excision repair_Homo sapiens_hsa034101.29051275
37Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.27681190
38TNF signaling pathway_Homo sapiens_hsa046681.25677989
39Apoptosis_Homo sapiens_hsa042101.25297025
40Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.25211661
41Glycosaminoglycan degradation_Homo sapiens_hsa005311.24097037
42T cell receptor signaling pathway_Homo sapiens_hsa046601.16836272
43Hepatitis B_Homo sapiens_hsa051611.16212821
44Rheumatoid arthritis_Homo sapiens_hsa053231.14041872
45Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.09702073
46Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.08958679
47Viral myocarditis_Homo sapiens_hsa054161.07615474
48Autoimmune thyroid disease_Homo sapiens_hsa053201.07125791
49Chemokine signaling pathway_Homo sapiens_hsa040621.03137774
50Acute myeloid leukemia_Homo sapiens_hsa052211.00362257
51SNARE interactions in vesicular transport_Homo sapiens_hsa041300.99621243
52Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.95043097
53Hepatitis C_Homo sapiens_hsa051600.94848679
54Protein export_Homo sapiens_hsa030600.94637258
55Platelet activation_Homo sapiens_hsa046110.94435476
56Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.91837111
57Pentose phosphate pathway_Homo sapiens_hsa000300.89271516
58Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.88969107
59Proteasome_Homo sapiens_hsa030500.87768787
60Transcriptional misregulation in cancer_Homo sapiens_hsa052020.87035091
61Pancreatic cancer_Homo sapiens_hsa052120.85142520
62Mismatch repair_Homo sapiens_hsa034300.84961777
63Phagosome_Homo sapiens_hsa041450.83616962
64Type I diabetes mellitus_Homo sapiens_hsa049400.80231281
65Epstein-Barr virus infection_Homo sapiens_hsa051690.79445662
66Ribosome_Homo sapiens_hsa030100.76976857
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.76913367
68Chronic myeloid leukemia_Homo sapiens_hsa052200.71943184
69AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.71562821
70Endocytosis_Homo sapiens_hsa041440.66473570
71Regulation of autophagy_Homo sapiens_hsa041400.65861848
72African trypanosomiasis_Homo sapiens_hsa051430.64564436
73Non-homologous end-joining_Homo sapiens_hsa034500.63542922
74Homologous recombination_Homo sapiens_hsa034400.61515065
75Viral carcinogenesis_Homo sapiens_hsa052030.59835621
76p53 signaling pathway_Homo sapiens_hsa041150.59649127
77Small cell lung cancer_Homo sapiens_hsa052220.59536607
78Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.54266092
79Collecting duct acid secretion_Homo sapiens_hsa049660.53748396
80Non-small cell lung cancer_Homo sapiens_hsa052230.53399404
81Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51920850
82HTLV-I infection_Homo sapiens_hsa051660.50787400
83Cell cycle_Homo sapiens_hsa041100.48840469
84Pyrimidine metabolism_Homo sapiens_hsa002400.44424449
85N-Glycan biosynthesis_Homo sapiens_hsa005100.44177157
86Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.43774141
87Carbohydrate digestion and absorption_Homo sapiens_hsa049730.41077469
88Folate biosynthesis_Homo sapiens_hsa007900.40614848
89Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.38824333
90Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.37912167
91Sphingolipid signaling pathway_Homo sapiens_hsa040710.37013594
92Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.35247289
93Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.34274082
94Nucleotide excision repair_Homo sapiens_hsa034200.33435484
95Prolactin signaling pathway_Homo sapiens_hsa049170.33280039
96Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.32929583
97Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.32634793
98VEGF signaling pathway_Homo sapiens_hsa043700.32062176
99Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.31585818
100Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.30707714
101Neurotrophin signaling pathway_Homo sapiens_hsa047220.30178152
102Sphingolipid metabolism_Homo sapiens_hsa006000.30082436
103Notch signaling pathway_Homo sapiens_hsa043300.26770481
104Arachidonic acid metabolism_Homo sapiens_hsa005900.25738220
105RNA polymerase_Homo sapiens_hsa030200.25689921
106Glutathione metabolism_Homo sapiens_hsa004800.25489072
107RNA degradation_Homo sapiens_hsa030180.25386799
108Glycerophospholipid metabolism_Homo sapiens_hsa005640.25140811
109Adipocytokine signaling pathway_Homo sapiens_hsa049200.25082039
110Histidine metabolism_Homo sapiens_hsa003400.24742136
111Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.23809966
112Amoebiasis_Homo sapiens_hsa051460.23537978
113alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.22706017
114Systemic lupus erythematosus_Homo sapiens_hsa053220.21903718
115Linoleic acid metabolism_Homo sapiens_hsa005910.21199905
116Drug metabolism - other enzymes_Homo sapiens_hsa009830.20572947
117Insulin resistance_Homo sapiens_hsa049310.19649299
118Choline metabolism in cancer_Homo sapiens_hsa052310.17637340
119Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.16759419
120Phosphatidylinositol signaling system_Homo sapiens_hsa040700.16043337
121Phospholipase D signaling pathway_Homo sapiens_hsa040720.14776945
122Chemical carcinogenesis_Homo sapiens_hsa052040.14533327
123FoxO signaling pathway_Homo sapiens_hsa040680.12637192
124Complement and coagulation cascades_Homo sapiens_hsa046100.11922290
125MAPK signaling pathway_Homo sapiens_hsa040100.11518471
126ABC transporters_Homo sapiens_hsa020100.11102098
127Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.09877273
128Renin secretion_Homo sapiens_hsa049240.09798873

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »