DAZAP2P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)8.27512457
2cytidine deamination (GO:0009972)7.88320780
3cytidine metabolic process (GO:0046087)7.88320780
4cytidine catabolic process (GO:0006216)7.88320780
5regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450917.84447599
6pyrimidine ribonucleoside catabolic process (GO:0046133)6.79562261
7cornea development in camera-type eye (GO:0061303)5.84074517
8positive T cell selection (GO:0043368)5.24504496
9regulation of regulatory T cell differentiation (GO:0045589)4.95104258
10positive regulation of defense response to virus by host (GO:0002230)4.92120827
11positive thymic T cell selection (GO:0045059)4.86107289
12antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.52447951
13Arp2/3 complex-mediated actin nucleation (GO:0034314)4.39099811
14negative T cell selection (GO:0043383)4.15761984
15positive regulation of leukocyte mediated cytotoxicity (GO:0001912)4.14800941
16cellular response to interleukin-15 (GO:0071350)4.14635597
17positive regulation of natural killer cell mediated immunity (GO:0002717)4.07443222
18actin nucleation (GO:0045010)4.02796838
19positive regulation of T cell mediated cytotoxicity (GO:0001916)4.01122868
20positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.93914190
21positive regulation of cell fate commitment (GO:0010455)3.93538770
22pyrimidine nucleoside catabolic process (GO:0046135)3.90580662
23negative regulation of viral genome replication (GO:0045071)3.87630553
24regulation of leukocyte mediated cytotoxicity (GO:0001910)3.79303324
25response to interferon-beta (GO:0035456)3.73710236
26positive regulation of cell killing (GO:0031343)3.69049827
27protein neddylation (GO:0045116)3.68714735
28regulation of T cell mediated cytotoxicity (GO:0001914)3.68253943
29regulation of activation of Janus kinase activity (GO:0010533)3.64497698
30regulation of timing of cell differentiation (GO:0048505)3.59427846
31positive regulation of calcium-mediated signaling (GO:0050850)3.56835586
32regulation of glucokinase activity (GO:0033131)3.55107095
33regulation of hexokinase activity (GO:1903299)3.55107095
34adaptation of signaling pathway (GO:0023058)3.53219116
35regulation of natural killer cell mediated immunity (GO:0002715)3.51684773
36regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.51684773
37negative regulation of T cell apoptotic process (GO:0070233)3.50200186
38positive regulation of alpha-beta T cell proliferation (GO:0046641)3.50063686
39regulation of cell killing (GO:0031341)3.44101678
40regulation of immunoglobulin secretion (GO:0051023)3.35920247
41thymic T cell selection (GO:0045061)3.35015804
42positive regulation of tolerance induction (GO:0002645)3.29841877
43positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.26209115
44regulation of development, heterochronic (GO:0040034)3.25649526
45negative regulation by host of viral transcription (GO:0043922)3.21955048
46regulation of defense response to virus by host (GO:0050691)3.21221213
47positive regulation of natural killer cell differentiation (GO:0032825)3.15886426
48response to interleukin-15 (GO:0070672)3.14404011
49T cell selection (GO:0045058)3.10584325
50positive regulation of actin filament depolymerization (GO:0030836)3.10096576
51regulation of T cell tolerance induction (GO:0002664)3.09315611
52regulation of T cell receptor signaling pathway (GO:0050856)3.07902185
53regulation of gamma-delta T cell differentiation (GO:0045586)3.06805127
54positive regulation of T cell mediated immunity (GO:0002711)3.06041306
55negative thymic T cell selection (GO:0045060)3.03609580
56sequestering of actin monomers (GO:0042989)3.03462251
57positive regulation of B cell differentiation (GO:0045579)3.02518868
58immunoglobulin mediated immune response (GO:0016064)2.99349888
59negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.97861338
60regulation of alpha-beta T cell proliferation (GO:0046640)2.96923088
61regulation of viral genome replication (GO:0045069)2.94973007
62T cell receptor signaling pathway (GO:0050852)2.94670011
63regulation of memory T cell differentiation (GO:0043380)2.92945910
64positive regulation of interleukin-8 secretion (GO:2000484)2.87792696
65mast cell activation involved in immune response (GO:0002279)2.85891590
66mast cell degranulation (GO:0043303)2.85891590
67platelet dense granule organization (GO:0060155)2.85382284
68mast cell activation (GO:0045576)2.84001601
69positive regulation of T cell cytokine production (GO:0002726)2.82504022
70positive regulation of interleukin-4 production (GO:0032753)2.79906546
71negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.79170235
72tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.78899132
73RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.78899132
74regulation of RIG-I signaling pathway (GO:0039535)2.77237767
75negative regulation of mast cell activation (GO:0033004)2.76836758
76proteasome assembly (GO:0043248)2.75104731
77positive regulation of lymphocyte mediated immunity (GO:0002708)2.74012103
78negative regulation of cell killing (GO:0031342)2.73236492
79negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.73236492
80cellular response to ATP (GO:0071318)2.72295065
81regulation of calcium-mediated signaling (GO:0050848)2.71205988
82negative regulation of lymphocyte apoptotic process (GO:0070229)2.71153939
83piRNA metabolic process (GO:0034587)2.68770215
84regulation of interleukin-8 secretion (GO:2000482)2.67370870
85B cell mediated immunity (GO:0019724)2.67013849
86cellular defense response (GO:0006968)2.64273655
87regulation of chronic inflammatory response (GO:0002676)2.63278795
88astrocyte differentiation (GO:0048708)2.62898123
89regulation of natural killer cell differentiation (GO:0032823)2.61088505
90somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.60885107
91somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.60885107
92isotype switching (GO:0045190)2.60885107
93positive regulation of interleukin-12 production (GO:0032735)2.58326902
94response to gravity (GO:0009629)2.57955244
95positive regulation of gamma-delta T cell activation (GO:0046645)2.56813532
96T cell costimulation (GO:0031295)2.56531279
97pyrimidine ribonucleoside metabolic process (GO:0046131)2.55022680
98lymphocyte costimulation (GO:0031294)2.53604826
99eosinophil chemotaxis (GO:0048245)2.51897535
100negative regulation of thymocyte apoptotic process (GO:0070244)2.51393563

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.08079325
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.77698940
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.22737316
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.43449466
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.30586240
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.09324187
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.92596012
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.73596914
9VDR_22108803_ChIP-Seq_LS180_Human2.68445487
10IRF8_21731497_ChIP-ChIP_J774_Mouse2.42394188
11STAT4_19710469_ChIP-ChIP_TH1__Mouse2.40695825
12MYB_26560356_Chip-Seq_TH2_Human2.40614547
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.36057711
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.34045805
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.31441112
16FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.24908813
17VDR_23849224_ChIP-Seq_CD4+_Human2.22420462
18RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.20859751
19SRF_21415370_ChIP-Seq_HL-1_Mouse2.17577468
20EST1_17652178_ChIP-ChIP_JURKAT_Human2.12858033
21FLI1_27457419_Chip-Seq_LIVER_Mouse2.07405820
22FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.05662982
23KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.94859794
24LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.86269784
25SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.86043395
26HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.81884590
27GATA3_26560356_Chip-Seq_TH2_Human1.77930871
28FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.75064448
29RUNX_20019798_ChIP-Seq_JUKART_Human1.67139792
30AUTS2_25519132_ChIP-Seq_293T-REX_Human1.65732550
31CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.65506929
32GATA3_27048872_Chip-Seq_THYMUS_Human1.62625607
33PCGF2_27294783_Chip-Seq_ESCs_Mouse1.61388484
34TDRD3_21172665_ChIP-Seq_MCF-7_Human1.57545879
35STAT6_21828071_ChIP-Seq_BEAS2B_Human1.57303123
36NOTCH1_21737748_ChIP-Seq_TLL_Human1.53181638
37CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.51119723
38PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.49565112
39TP53_22573176_ChIP-Seq_HFKS_Human1.48554373
40RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.45945330
41ETS1_20019798_ChIP-Seq_JURKAT_Human1.45079565
42EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.44968238
43NANOG_20526341_ChIP-Seq_ESCs_Human1.44920818
44FOXP3_21729870_ChIP-Seq_TREG_Human1.44561354
45MYB_26560356_Chip-Seq_TH1_Human1.43736598
46HTT_18923047_ChIP-ChIP_STHdh_Human1.42546272
47FOXA1_25329375_ChIP-Seq_VCAP_Human1.40972468
48FOXA1_27270436_Chip-Seq_PROSTATE_Human1.40972468
49ZNF274_21170338_ChIP-Seq_K562_Hela1.39584886
50ELK1_19687146_ChIP-ChIP_HELA_Human1.38481351
51CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.36954037
52GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.36181133
53MYC_18940864_ChIP-ChIP_HL60_Human1.35610442
54EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.34173780
55AR_20517297_ChIP-Seq_VCAP_Human1.31049196
56PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.30145653
57CBP_20019798_ChIP-Seq_JUKART_Human1.28049159
58IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.28049159
59GATA3_21878914_ChIP-Seq_MCF-7_Human1.27938350
60TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.27512543
61PCGF2_27294783_Chip-Seq_NPCs_Mouse1.24898688
62ERA_21632823_ChIP-Seq_H3396_Human1.24204249
63BCL6_27268052_Chip-Seq_Bcells_Human1.21810920
64SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.20454728
65STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.19987878
66HOXB4_20404135_ChIP-ChIP_EML_Mouse1.19852181
67GBX2_23144817_ChIP-Seq_PC3_Human1.18658095
68NCOR_22424771_ChIP-Seq_293T_Human1.15353748
69CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.12963952
70HOXB7_26014856_ChIP-Seq_BT474_Human1.09900155
71FOXA1_21572438_ChIP-Seq_LNCaP_Human1.06568615
72CTCF_20526341_ChIP-Seq_ESCs_Human1.06563695
73MYC_19829295_ChIP-Seq_ESCs_Human1.06224989
74SPI1_23547873_ChIP-Seq_NB4_Human1.05826460
75P300_27268052_Chip-Seq_Bcells_Human1.04748122
76MAF_26560356_Chip-Seq_TH2_Human1.03534444
77ER_23166858_ChIP-Seq_MCF-7_Human1.03133263
78FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01519307
79FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.00210717
80TAF2_19829295_ChIP-Seq_ESCs_Human1.00024443
81RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.99706383
82EGR1_23403033_ChIP-Seq_LIVER_Mouse0.99613453
83UTX_26944678_Chip-Seq_JUKART_Human0.98548005
84PADI4_21655091_ChIP-ChIP_MCF-7_Human0.97723998
85IGF1R_20145208_ChIP-Seq_DFB_Human0.94226395
86P53_21459846_ChIP-Seq_SAOS-2_Human0.93004797
87ERG_20517297_ChIP-Seq_VCAP_Human0.92715137
88STAT1_20625510_ChIP-Seq_HELA_Human0.92102649
89LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.91963944
90POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.90939707
91RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.89528960
92GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.88776895
93CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.88599294
94CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.87910444
95TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.86449249
96BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.86134629
97BCOR_27268052_Chip-Seq_Bcells_Human0.84650274
98YY1_22570637_ChIP-Seq_MALME-3M_Human0.84460753
99NFE2_27457419_Chip-Seq_LIVER_Mouse0.84100853
100CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.83742415

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode4.69748879
2MP0005671_abnormal_response_to4.50441996
3MP0005257_abnormal_intraocular_pressure4.40756446
4MP0002638_abnormal_pupillary_reflex3.88749683
5MP0008789_abnormal_olfactory_epithelium3.30511201
6MP0001835_abnormal_antigen_presentation2.97713744
7MP0009785_altered_susceptibility_to2.86865451
8MP0008877_abnormal_DNA_methylation2.52606284
9MP0003763_abnormal_thymus_physiology2.45608576
10MP0005000_abnormal_immune_tolerance2.35864155
11MP0006054_spinal_hemorrhage2.34890890
12MP0005499_abnormal_olfactory_system2.20028210
13MP0005394_taste/olfaction_phenotype2.20028210
14MP0001800_abnormal_humoral_immune2.13403065
15MP0002723_abnormal_immune_serum2.08514273
16MP0002420_abnormal_adaptive_immunity2.02391437
17MP0001819_abnormal_immune_cell1.97114700
18MP0000685_abnormal_immune_system1.94428642
19MP0005025_abnormal_response_to1.93333442
20MP0001790_abnormal_immune_system1.90922998
21MP0005387_immune_system_phenotype1.90922998
22MP0002148_abnormal_hypersensitivity_rea1.86937845
23MP0004381_abnormal_hair_follicle1.85766981
24MP0002452_abnormal_antigen_presenting1.82076895
25MP0002166_altered_tumor_susceptibility1.82045528
26MP0003806_abnormal_nucleotide_metabolis1.81133406
27MP0004147_increased_porphyrin_level1.80541957
28MP0003646_muscle_fatigue1.74377358
29MP0003786_premature_aging1.70714290
30MP0002102_abnormal_ear_morphology1.70373590
31MP0002006_tumorigenesis1.69663257
32MP0002160_abnormal_reproductive_system1.62704735
33MP0001873_stomach_inflammation1.57289731
34MP0005084_abnormal_gallbladder_morpholo1.54480820
35MP0003866_abnormal_defecation1.53388497
36MP0001919_abnormal_reproductive_system1.52690301
37MP0003724_increased_susceptibility_to1.52313398
38MP0009333_abnormal_splenocyte_physiolog1.50988781
39MP0002398_abnormal_bone_marrow1.50941763
40MP0000716_abnormal_immune_system1.50561614
41MP0005075_abnormal_melanosome_morpholog1.49437201
42MP0005389_reproductive_system_phenotype1.44823535
43MP0010155_abnormal_intestine_physiology1.41153224
44MP0008875_abnormal_xenobiotic_pharmacok1.41005733
45MP0002933_joint_inflammation1.40283673
46MP0001853_heart_inflammation1.39804138
47MP0005083_abnormal_biliary_tract1.35696225
48MP0000689_abnormal_spleen_morphology1.35382232
49MP0002722_abnormal_immune_system1.34860127
50MP0002938_white_spotting1.31944233
51MP0001845_abnormal_inflammatory_respons1.28867844
52MP0000383_abnormal_hair_follicle1.25527767
53MP0000613_abnormal_salivary_gland1.23683352
54MP0005410_abnormal_fertilization1.23609669
55MP0000372_irregular_coat_pigmentation1.18975935
56MP0008007_abnormal_cellular_replicative1.18762098
57MP0004885_abnormal_endolymph1.16941786
58MP0000703_abnormal_thymus_morphology1.16288928
59MP0002429_abnormal_blood_cell1.16234831
60MP0002405_respiratory_system_inflammati1.15429895
61MP0006072_abnormal_retinal_apoptosis1.14067103
62MP0008872_abnormal_physiological_respon1.10612038
63MP0001968_abnormal_touch/_nociception1.08532185
64MP0003787_abnormal_imprinting1.06206627
65MP0001542_abnormal_bone_strength1.05155594
66MP0002419_abnormal_innate_immunity1.03367088
67MP0002019_abnormal_tumor_incidence1.00379134
68MP0001905_abnormal_dopamine_level0.98155683
69MP0002876_abnormal_thyroid_physiology0.97614130
70MP0009764_decreased_sensitivity_to0.95400280
71MP0005464_abnormal_platelet_physiology0.95295614
72MP0002693_abnormal_pancreas_physiology0.94839965
73MP0003448_altered_tumor_morphology0.91744741
74MP0004947_skin_inflammation0.88923023
75MP0003011_delayed_dark_adaptation0.88495734
76MP0002837_dystrophic_cardiac_calcinosis0.84969787
77MP0002095_abnormal_skin_pigmentation0.84844423
78MP0005646_abnormal_pituitary_gland0.84536314
79MP0006082_CNS_inflammation0.83844307
80MP0008469_abnormal_protein_level0.82078470
81MP0005551_abnormal_eye_electrophysiolog0.81238540
82MP0001533_abnormal_skeleton_physiology0.76895088
83MP0009763_increased_sensitivity_to0.76665654
84MP0004145_abnormal_muscle_electrophysio0.76656803
85MP0005174_abnormal_tail_pigmentation0.76480160
86MP0010678_abnormal_skin_adnexa0.76352708
87MP0000858_altered_metastatic_potential0.76022888
88MP0003436_decreased_susceptibility_to0.74940884
89MP0003878_abnormal_ear_physiology0.72251390
90MP0005377_hearing/vestibular/ear_phenot0.72251390
91MP0005253_abnormal_eye_physiology0.66470790
92MP0010386_abnormal_urinary_bladder0.66401161
93MP0003638_abnormal_response/metabolism_0.66185935
94MP0001243_abnormal_dermal_layer0.64617347
95MP0005360_urolithiasis0.62100443
96MP0002277_abnormal_respiratory_mucosa0.60621940
97MP0001944_abnormal_pancreas_morphology0.57524053
98MP0005645_abnormal_hypothalamus_physiol0.56431782
99MP0003137_abnormal_impulse_conducting0.55234197
100MP0001765_abnormal_ion_homeostasis0.55182593

Predicted human phenotypes

RankGene SetZ-score
1Hypoplasia of the fovea (HP:0007750)6.38232631
2Aplasia/Hypoplasia of the fovea (HP:0008060)6.38232631
3Abnormality of the fovea (HP:0000493)5.07364203
4IgG deficiency (HP:0004315)4.97827561
5Stomatitis (HP:0010280)4.53679592
6Increased IgM level (HP:0003496)4.46102525
7Aplasia/Hypoplasia of the macula (HP:0008059)4.44093426
8Elevated erythrocyte sedimentation rate (HP:0003565)4.39984360
9Congenital stationary night blindness (HP:0007642)4.25988606
10Aplasia/Hypoplasia affecting the retina (HP:0008061)4.15483774
11T lymphocytopenia (HP:0005403)4.08208254
12Abnormality of T cell number (HP:0011839)3.89534142
13Severe combined immunodeficiency (HP:0004430)3.69242269
14Aplastic anemia (HP:0001915)3.45796917
15Abnormality of the prostate (HP:0008775)3.20343922
16Hypoproteinemia (HP:0003075)3.19306311
17Thyroiditis (HP:0100646)3.00040236
18Abnormality of T cells (HP:0002843)2.96169850
19Abnormality of eosinophils (HP:0001879)2.88465110
20Combined immunodeficiency (HP:0005387)2.88031805
21Decreased central vision (HP:0007663)2.77115201
22Abnormality of alanine metabolism (HP:0010916)2.66249869
23Hyperalaninemia (HP:0003348)2.66249869
24Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.66249869
25Prostate neoplasm (HP:0100787)2.57873871
26Mitochondrial inheritance (HP:0001427)2.54993110
27Absent rod-and cone-mediated responses on ERG (HP:0007688)2.53889462
28Abnormal rod and cone electroretinograms (HP:0008323)2.50021692
29Methylmalonic acidemia (HP:0002912)2.45458973
30Methylmalonic aciduria (HP:0012120)2.43034068
31Rib fusion (HP:0000902)2.41810102
32Anomalous pulmonary venous return (HP:0010772)2.41646250
33Autoimmune hemolytic anemia (HP:0001890)2.41491029
34Reduced antithrombin III activity (HP:0001976)2.37653821
35Type II lissencephaly (HP:0007260)2.22780804
36Pustule (HP:0200039)2.21699690
37Abolished electroretinogram (ERG) (HP:0000550)2.20899688
38IgA deficiency (HP:0002720)2.20496728
39Hepatocellular necrosis (HP:0001404)2.20053376
40Hypergammaglobulinemia (HP:0010702)2.19946134
41Keratitis (HP:0000491)2.19493104
42Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.17665565
43Optic nerve hypoplasia (HP:0000609)2.15736551
44Attenuation of retinal blood vessels (HP:0007843)2.12432685
45Large eyes (HP:0001090)2.10679718
46Increased CSF lactate (HP:0002490)2.08594376
47Abnormality of the pulmonary veins (HP:0011718)2.07688273
48Abnormal albumin level (HP:0012116)2.05741878
49Hypoalbuminemia (HP:0003073)2.05741878
50Abnormality of T cell physiology (HP:0011840)2.04669619
51Acute necrotizing encephalopathy (HP:0006965)2.03465484
52Eosinophilia (HP:0001880)2.02230975
53Hepatic necrosis (HP:0002605)2.01636041
54Abnormality of the renal cortex (HP:0011035)1.97532501
55Clubbing of toes (HP:0100760)1.97252541
56Lymphopenia (HP:0001888)1.95534029
57Recurrent bronchitis (HP:0002837)1.95452033
58Pendular nystagmus (HP:0012043)1.95083898
59Increased intramyocellular lipid droplets (HP:0012240)1.94842224
60Pancytopenia (HP:0001876)1.94636708
61Aplasia/Hypoplasia of the uvula (HP:0010293)1.93450223
62Abnormality of the ileum (HP:0001549)1.92530065
63Encephalitis (HP:0002383)1.91486466
64Decreased electroretinogram (ERG) amplitude (HP:0000654)1.91262561
65Pancreatic cysts (HP:0001737)1.90948572
66Joint swelling (HP:0001386)1.90231318
67Myositis (HP:0100614)1.88957419
68True hermaphroditism (HP:0010459)1.87200459
69Renal cortical cysts (HP:0000803)1.86901904
70Optic nerve coloboma (HP:0000588)1.86834674
71Gangrene (HP:0100758)1.86476533
72Petechiae (HP:0000967)1.85233094
73IgM deficiency (HP:0002850)1.84943049
74Increased hepatocellular lipid droplets (HP:0006565)1.81163504
75Pulmonary infiltrates (HP:0002113)1.80962362
76Chronic diarrhea (HP:0002028)1.80456506
77Leukocytosis (HP:0001974)1.80386962
78Meckel diverticulum (HP:0002245)1.78654465
79Abnormality of cells of the lymphoid lineage (HP:0012140)1.77971146
80Optic neuritis (HP:0100653)1.77697785
81Retrobulbar optic neuritis (HP:0100654)1.77697785
82Abnormal mitochondria in muscle tissue (HP:0008316)1.77275276
83Conical tooth (HP:0000698)1.76931267
84Abnormality of male internal genitalia (HP:0000022)1.76460387
85Abnormality of the preputium (HP:0100587)1.73600978
86Dicarboxylic aciduria (HP:0003215)1.73111976
87Abnormality of dicarboxylic acid metabolism (HP:0010995)1.73111976
88Increased serum lactate (HP:0002151)1.71759103
89Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.71358024
90Cerebral edema (HP:0002181)1.67043500
91Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.65406587
92Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.65147383
93Absent thumb (HP:0009777)1.64780636
94Renal Fanconi syndrome (HP:0001994)1.64257293
95Molar tooth sign on MRI (HP:0002419)1.62912938
96Abnormality of midbrain morphology (HP:0002418)1.62912938
97Cerebral palsy (HP:0100021)1.61971287
98Amyotrophic lateral sclerosis (HP:0007354)1.61953820
99Chronic sinusitis (HP:0011109)1.61843388
100Type 2 muscle fiber atrophy (HP:0003554)1.61657892

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.96933248
2KDR4.40562558
3VRK24.02357973
4TESK23.96674551
5BCKDK2.63701835
6MAPK132.35442245
7PTK2B2.27689314
8MAP4K12.18128583
9MST42.17715116
10ADRBK21.99897685
11VRK11.89407474
12TAOK31.86683350
13CDK191.84942264
14BUB11.79121264
15TLK11.78603772
16MAP3K121.78236860
17TESK11.77234676
18MAPKAPK31.69984428
19FES1.68599124
20NUAK11.63125353
21HIPK21.57654774
22GRK11.53763820
23SYK1.53119402
24STK161.51088123
25ITK1.49662444
26LIMK11.43102686
27ZAP701.38649554
28BTK1.36747017
29GRK71.36212939
30MUSK1.35244542
31IKBKB1.32262829
32FRK1.29396365
33DAPK11.26909894
34ZAK1.23614016
35IKBKE1.19447594
36MYLK1.19191611
37ARAF1.14351812
38TEC1.13518484
39MAP4K21.06560969
40CSK1.03847971
41PHKG20.99220886
42PHKG10.99220886
43PIM20.98745924
44KIT0.97252408
45TBK10.91846570
46PIK3CA0.91570894
47CSF1R0.88838365
48PRKCQ0.88711047
49RPS6KA50.87466054
50DAPK20.86307527
51NME10.84645581
52STK100.78955596
53LCK0.76783898
54EIF2AK20.76609821
55EIF2AK30.73738279
56GRK60.71762040
57INSRR0.70992887
58GRK50.69480019
59LYN0.67383036
60MAP2K60.66723351
61CSNK1G30.64739719
62BMPR1B0.64438961
63TIE10.64145245
64ADRBK10.58881207
65HCK0.56340313
66WNK30.54787103
67SRPK10.54420140
68TGFBR20.54409357
69CSNK1A1L0.51988972
70MAP3K110.51429081
71BRSK20.44046086
72MAP3K140.43742909
73PRKCI0.41794301
74JAK10.39926637
75WEE10.39099115
76FLT30.38725727
77MAPK110.38238946
78MAPKAPK50.37809076
79EPHA20.35474530
80OBSCN0.34400140
81ROCK10.34398382
82TRPM70.34095826
83PAK10.33972645
84TYK20.33817267
85CSNK1G20.33514901
86MAPKAPK20.32795932
87IGF1R0.32414596
88CSNK1G10.31211250
89ATR0.31203657
90PDK20.30330469
91STK38L0.29748702
92TNK20.28790015
93NLK0.28778643
94CHUK0.27830620
95RPS6KB20.27827572
96CSNK1D0.25833507
97MOS0.25440122
98CSNK1A10.25219383
99PRKCA0.24889569
100PLK40.24747190

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.87054152
2Proteasome_Homo sapiens_hsa030503.83876410
3Autoimmune thyroid disease_Homo sapiens_hsa053203.39304163
4Allograft rejection_Homo sapiens_hsa053303.24418310
5Graft-versus-host disease_Homo sapiens_hsa053323.19861630
6Antigen processing and presentation_Homo sapiens_hsa046123.07242854
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.57457109
8Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.52190165
9Asthma_Homo sapiens_hsa053102.49089602
10Oxidative phosphorylation_Homo sapiens_hsa001902.39992983
11Hematopoietic cell lineage_Homo sapiens_hsa046402.37437301
12Type I diabetes mellitus_Homo sapiens_hsa049402.21724605
13Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.06075624
14Parkinsons disease_Homo sapiens_hsa050121.91059560
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.73312617
16NF-kappa B signaling pathway_Homo sapiens_hsa040641.73245781
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.70033729
18T cell receptor signaling pathway_Homo sapiens_hsa046601.69120819
19Maturity onset diabetes of the young_Homo sapiens_hsa049501.66827985
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.58762486
21Rheumatoid arthritis_Homo sapiens_hsa053231.49894300
22Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.46491935
23Fanconi anemia pathway_Homo sapiens_hsa034601.40395032
24Caffeine metabolism_Homo sapiens_hsa002321.39365688
25Alzheimers disease_Homo sapiens_hsa050101.28906800
26Homologous recombination_Homo sapiens_hsa034401.26812460
27Viral myocarditis_Homo sapiens_hsa054161.26029832
28Measles_Homo sapiens_hsa051621.25230588
29Malaria_Homo sapiens_hsa051441.23229439
30DNA replication_Homo sapiens_hsa030301.18440792
31Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.15348193
32RNA polymerase_Homo sapiens_hsa030201.13143934
33Phototransduction_Homo sapiens_hsa047441.09753399
34Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.07481037
35Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.07060085
36RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.05377822
37Huntingtons disease_Homo sapiens_hsa050161.03907198
38Mismatch repair_Homo sapiens_hsa034301.03714914
39Linoleic acid metabolism_Homo sapiens_hsa005911.03496774
40Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.99106104
41Nitrogen metabolism_Homo sapiens_hsa009100.98725482
42Pyrimidine metabolism_Homo sapiens_hsa002400.97939576
43SNARE interactions in vesicular transport_Homo sapiens_hsa041300.95920789
44Nucleotide excision repair_Homo sapiens_hsa034200.94200633
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.94015080
46RNA degradation_Homo sapiens_hsa030180.92798807
47Steroid hormone biosynthesis_Homo sapiens_hsa001400.87493526
48Vitamin B6 metabolism_Homo sapiens_hsa007500.87373423
49Herpes simplex infection_Homo sapiens_hsa051680.86291630
50NOD-like receptor signaling pathway_Homo sapiens_hsa046210.81720451
51Shigellosis_Homo sapiens_hsa051310.79431597
52Cardiac muscle contraction_Homo sapiens_hsa042600.79267507
53Chemical carcinogenesis_Homo sapiens_hsa052040.77682594
54Systemic lupus erythematosus_Homo sapiens_hsa053220.75084628
55Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.73407474
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.73023132
57Pentose phosphate pathway_Homo sapiens_hsa000300.71191868
58Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.71184459
59Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.69545227
60Staphylococcus aureus infection_Homo sapiens_hsa051500.66336690
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.64258813
62Protein export_Homo sapiens_hsa030600.64122435
63Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.59939445
64Ribosome_Homo sapiens_hsa030100.58818429
65Purine metabolism_Homo sapiens_hsa002300.57115608
66Retinol metabolism_Homo sapiens_hsa008300.56794200
67Arachidonic acid metabolism_Homo sapiens_hsa005900.55589011
68Legionellosis_Homo sapiens_hsa051340.55484657
69Olfactory transduction_Homo sapiens_hsa047400.53685522
70Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.53418991
71HTLV-I infection_Homo sapiens_hsa051660.51760071
72Drug metabolism - other enzymes_Homo sapiens_hsa009830.51715071
73Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.50138708
74Tryptophan metabolism_Homo sapiens_hsa003800.49215959
752-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.46346140
76Basal transcription factors_Homo sapiens_hsa030220.45364977
77Sulfur relay system_Homo sapiens_hsa041220.45341636
78Base excision repair_Homo sapiens_hsa034100.45254547
79alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.43557943
80Salmonella infection_Homo sapiens_hsa051320.42932200
81Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40056719
82One carbon pool by folate_Homo sapiens_hsa006700.39070940
83Leishmaniasis_Homo sapiens_hsa051400.38885926
84Propanoate metabolism_Homo sapiens_hsa006400.38793960
85Fat digestion and absorption_Homo sapiens_hsa049750.38473076
86Metabolic pathways_Homo sapiens_hsa011000.33335573
87Sulfur metabolism_Homo sapiens_hsa009200.32174863
88Taste transduction_Homo sapiens_hsa047420.32095321
89RNA transport_Homo sapiens_hsa030130.31415222
90Salivary secretion_Homo sapiens_hsa049700.27632027
91Jak-STAT signaling pathway_Homo sapiens_hsa046300.27317741
92Peroxisome_Homo sapiens_hsa041460.26319208
93Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.25509690
94Epstein-Barr virus infection_Homo sapiens_hsa051690.25109710
95Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.24732223
96Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.24558573
97Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.23823034
98Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.22324934
99Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.19860639
100Biosynthesis of amino acids_Homo sapiens_hsa012300.18777794

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