DAZL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The DAZ (Deleted in AZoospermia) gene family encodes potential RNA binding proteins that are expressed in prenatal and postnatal germ cells of males and females. The protein encoded by this gene is localized to the nucleus and cytoplasm of fetal germ cells and to the cytoplasm of developing oocytes. In the testis, this protein is localized to the nucleus of spermatogonia but relocates to the cytoplasm during meiosis where it persists in spermatids and spermatozoa. Transposition and amplification of this autosomal gene during primate evolution gave rise to the DAZ gene cluster on the Y chromosome. Mutations in this gene have been linked to severe spermatogenic failure and infertility in males. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1male meiosis (GO:0007140)9.45047811
2chromosome organization involved in meiosis (GO:0070192)8.04802978
3gonadal mesoderm development (GO:0007506)7.78452180
4* meiotic nuclear division (GO:0007126)7.55369898
5male meiosis I (GO:0007141)7.20860444
6meiotic chromosome segregation (GO:0045132)7.07771822
7gene silencing by RNA (GO:0031047)6.29082476
8DNA alkylation (GO:0006305)6.11517817
9DNA methylation (GO:0006306)6.11517817
10meiosis I (GO:0007127)6.09826213
11oogenesis (GO:0048477)6.03340060
12negative regulation of meiosis (GO:0045835)5.82144757
13reciprocal meiotic recombination (GO:0007131)5.74315977
14reciprocal DNA recombination (GO:0035825)5.74315977
15attachment of spindle microtubules to kinetochore (GO:0008608)5.73980625
16* meiotic cell cycle process (GO:1903046)5.52028115
17female gamete generation (GO:0007292)5.27225685
18resolution of meiotic recombination intermediates (GO:0000712)5.11907991
19nuclear pore complex assembly (GO:0051292)5.09785983
20sister chromatid cohesion (GO:0007062)5.06879498
21nuclear pore organization (GO:0006999)5.02557965
22DNA synthesis involved in DNA repair (GO:0000731)5.02500207
23mitotic chromosome condensation (GO:0007076)4.84082623
24DNA methylation or demethylation (GO:0044728)4.69707625
25heterochromatin organization (GO:0070828)4.62525903
26histone H3-K9 demethylation (GO:0033169)4.58690637
27gene silencing (GO:0016458)4.52840427
28kinetochore organization (GO:0051383)4.36125506
29DNA replication checkpoint (GO:0000076)4.30337891
30oocyte development (GO:0048599)4.27496200
31regulation of DNA endoreduplication (GO:0032875)4.24866648
32kinetochore assembly (GO:0051382)4.09197646
33protein K6-linked ubiquitination (GO:0085020)4.01365457
34synapsis (GO:0007129)4.00306290
35meiotic cell cycle (GO:0051321)3.95410049
36DNA modification (GO:0006304)3.94675868
37chromatin remodeling at centromere (GO:0031055)3.93642951
38regulation of double-strand break repair via homologous recombination (GO:0010569)3.85149808
39metaphase plate congression (GO:0051310)3.83209685
40negative regulation of meiotic cell cycle (GO:0051447)3.74870302
41mitotic metaphase plate congression (GO:0007080)3.74092253
42negative regulation of gene silencing (GO:0060969)3.73125341
43mitotic spindle assembly checkpoint (GO:0007094)3.72263990
44DNA replication-dependent nucleosome organization (GO:0034723)3.72041770
45DNA replication-dependent nucleosome assembly (GO:0006335)3.72041770
46pore complex assembly (GO:0046931)3.69763680
47spermatid development (GO:0007286)3.68033168
48binding of sperm to zona pellucida (GO:0007339)3.67196139
49spindle assembly checkpoint (GO:0071173)3.66664110
50* positive regulation of meiosis (GO:0045836)3.65566812
51mitotic spindle checkpoint (GO:0071174)3.65103774
52negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.65019921
53* regulation of meiotic cell cycle (GO:0051445)3.63794075
54histone exchange (GO:0043486)3.63371312
55negative regulation of chromosome segregation (GO:0051985)3.62832652
56mitotic sister chromatid cohesion (GO:0007064)3.59935821
57negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.59119522
58negative regulation of sister chromatid segregation (GO:0033046)3.59119522
59negative regulation of mitotic sister chromatid separation (GO:2000816)3.59119522
60negative regulation of mitotic sister chromatid segregation (GO:0033048)3.59119522
61regulation of chromosome segregation (GO:0051983)3.52753353
62histone H4-K12 acetylation (GO:0043983)3.50712483
63spindle checkpoint (GO:0031577)3.50640762
64regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.49422334
65* regulation of meiosis (GO:0040020)3.47356189
66sex differentiation (GO:0007548)3.46454519
67chromosome organization (GO:0051276)3.45287071
68regulation of mitotic metaphase/anaphase transition (GO:0030071)3.44531386
69negative regulation of nuclear division (GO:0051784)3.43627319
70regulation of sister chromatid segregation (GO:0033045)3.40008569
71regulation of mitotic sister chromatid separation (GO:0010965)3.40008569
72regulation of mitotic sister chromatid segregation (GO:0033047)3.40008569
73* positive regulation of meiotic cell cycle (GO:0051446)3.37845300
74DNA replication-independent nucleosome assembly (GO:0006336)3.37491002
75DNA replication-independent nucleosome organization (GO:0034724)3.37491002
76somatic hypermutation of immunoglobulin genes (GO:0016446)3.36023133
77somatic diversification of immune receptors via somatic mutation (GO:0002566)3.36023133
78mitotic nuclear envelope disassembly (GO:0007077)3.30810072
79inner cell mass cell proliferation (GO:0001833)3.27501116
80CENP-A containing nucleosome assembly (GO:0034080)3.27190520
81regulation of gene silencing by RNA (GO:0060966)3.25560579
82regulation of posttranscriptional gene silencing (GO:0060147)3.25560579
83regulation of gene silencing by miRNA (GO:0060964)3.25560579
84regulation of double-strand break repair (GO:2000779)3.24607316
85chromosome segregation (GO:0007059)3.23046792
86positive regulation of male gonad development (GO:2000020)3.22259057
87* nuclear division (GO:0000280)3.19877648
88proteasome assembly (GO:0043248)3.18944820
89embryonic body morphogenesis (GO:0010172)3.17731910
90nuclear envelope disassembly (GO:0051081)3.17174837
91membrane disassembly (GO:0030397)3.17174837
92centriole replication (GO:0007099)3.14054419
93DNA biosynthetic process (GO:0071897)3.11686864
94centriole assembly (GO:0098534)3.10936924
95* germ cell development (GO:0007281)3.10505882
96regulation of histone H3-K9 methylation (GO:0051570)3.09774220
97negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.08573277
98DNA packaging (GO:0006323)3.06746202
99mRNA export from nucleus (GO:0006406)3.02774349
100regulation of centriole replication (GO:0046599)3.02367941
101chromatin assembly or disassembly (GO:0006333)2.99369651
102fertilization (GO:0009566)2.99230859
103protein localization to chromosome (GO:0034502)2.99121488
104regulation of sister chromatid cohesion (GO:0007063)2.98128380
105negative regulation of cell division (GO:0051782)2.97808832
106positive regulation of mitotic sister chromatid separation (GO:1901970)2.96449091
107positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.96449091
108positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.96449091
109histone H3-K9 methylation (GO:0051567)2.95847763
110positive regulation of chromosome segregation (GO:0051984)2.94204955
111histone H2A acetylation (GO:0043968)2.93198561
112embryonic foregut morphogenesis (GO:0048617)2.87710487
113* male gamete generation (GO:0048232)2.86229481
114* spermatogenesis (GO:0007283)2.85004229
115* gamete generation (GO:0007276)2.83762026
116interkinetic nuclear migration (GO:0022027)2.83657461
117negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.80101247
118* organelle fission (GO:0048285)2.79571807
119acrosome reaction (GO:0007340)2.77183674
120sperm-egg recognition (GO:0035036)2.76893448
121protein localization to chromosome, centromeric region (GO:0071459)2.75573050
122histone H3-K36 demethylation (GO:0070544)2.75503242
123folic acid transport (GO:0015884)2.73808671
124* cellular process involved in reproduction in multicellular organism (GO:0022412)2.68685563
125piRNA metabolic process (GO:0034587)15.1551148
126DNA methylation involved in gamete generation (GO:0043046)12.2342833
127synaptonemal complex assembly (GO:0007130)11.4675757
128synaptonemal complex organization (GO:0070193)10.5971536
129regulation of meiosis I (GO:0060631)10.1881570

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.42237902
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.59924242
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse5.39474513
4FOXM1_23109430_ChIP-Seq_U2OS_Human5.19764507
5IGF1R_20145208_ChIP-Seq_DFB_Human4.10394165
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.99343651
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.67636157
8KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.40395337
9AR_21909140_ChIP-Seq_LNCAP_Human3.21655734
10MYC_18555785_ChIP-Seq_MESCs_Mouse3.04028130
11RBPJ_22232070_ChIP-Seq_NCS_Mouse2.93488487
12E2F1_21310950_ChIP-Seq_MCF-7_Human2.75591348
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.54085667
14MYCN_18555785_ChIP-Seq_MESCs_Mouse2.44207936
15KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.42167937
16KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.42167937
17KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.42167937
18ZNF274_21170338_ChIP-Seq_K562_Hela2.38196298
19HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.35920397
20NELFA_20434984_ChIP-Seq_ESCs_Mouse2.34050113
21E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.33401704
22SALL1_21062744_ChIP-ChIP_HESCs_Human2.25985858
23PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.23471329
24* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.17208549
25TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.10075372
26EGR1_19374776_ChIP-ChIP_THP-1_Human1.93564027
27CREB1_15753290_ChIP-ChIP_HEK293T_Human1.93474026
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.90869746
29MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.89585567
30KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.79478065
31MYC_19030024_ChIP-ChIP_MESCs_Mouse1.78951661
32NOTCH1_21737748_ChIP-Seq_TLL_Human1.77806321
33YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.77553961
34* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.77089533
35POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.76758115
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.76734223
37MYC_19079543_ChIP-ChIP_MESCs_Mouse1.76257862
38* RNF2_27304074_Chip-Seq_NSC_Mouse1.71133198
39GABP_17652178_ChIP-ChIP_JURKAT_Human1.64609153
40EZH2_22144423_ChIP-Seq_EOC_Human1.61593115
41EST1_17652178_ChIP-ChIP_JURKAT_Human1.61205462
42PADI4_21655091_ChIP-ChIP_MCF-7_Human1.58312081
43DCP1A_22483619_ChIP-Seq_HELA_Human1.53732367
44CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.53127042
45GATA1_26923725_Chip-Seq_HPCs_Mouse1.50931456
46KDM5A_27292631_Chip-Seq_BREAST_Human1.50793636
47XRN2_22483619_ChIP-Seq_HELA_Human1.46833330
48HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.44872324
49POU3F2_20337985_ChIP-ChIP_501MEL_Human1.43953385
50VDR_22108803_ChIP-Seq_LS180_Human1.43293702
51FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.41901778
52VDR_23849224_ChIP-Seq_CD4+_Human1.38555580
53GABP_19822575_ChIP-Seq_HepG2_Human1.36684021
54MYC_18358816_ChIP-ChIP_MESCs_Mouse1.36348637
55KLF4_18555785_ChIP-Seq_MESCs_Mouse1.35518669
56PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.32615624
57E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.32011030
58ETS1_20019798_ChIP-Seq_JURKAT_Human1.31615128
59JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.30079924
60* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.26113167
61TAF15_26573619_Chip-Seq_HEK293_Human1.23443580
62MYC_18940864_ChIP-ChIP_HL60_Human1.22336648
63CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.20015766
64THAP11_20581084_ChIP-Seq_MESCs_Mouse1.17816393
65TTF2_22483619_ChIP-Seq_HELA_Human1.16262682
66FOXP3_21729870_ChIP-Seq_TREG_Human1.16013883
67* RUNX1_26923725_Chip-Seq_HPCs_Mouse1.15446771
68BCAT_22108803_ChIP-Seq_LS180_Human1.15221654
69E2F1_18555785_ChIP-Seq_MESCs_Mouse1.14773546
70CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13520864
71UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10237081
72CIITA_25753668_ChIP-Seq_RAJI_Human1.07956190
73FOXA1_21572438_ChIP-Seq_LNCaP_Human1.05992039
74IRF1_19129219_ChIP-ChIP_H3396_Human1.05653546
75EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.05282055
76SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.04267631
77CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.03490602
78RUNX2_22187159_ChIP-Seq_PCA_Human1.02446153
79TP63_19390658_ChIP-ChIP_HaCaT_Human0.99353674
80TP53_22573176_ChIP-Seq_HFKS_Human0.98071903
81TFEB_21752829_ChIP-Seq_HELA_Human0.95226821
82STAT3_1855785_ChIP-Seq_MESCs_Mouse0.94567617
83PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.94501702
84ER_23166858_ChIP-Seq_MCF-7_Human0.93186568
85GATA3_26560356_Chip-Seq_TH1_Human0.93145104
86REST_19997604_ChIP-ChIP_NEURONS_Mouse0.92558123
87FUS_26573619_Chip-Seq_HEK293_Human0.91542875
88ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.89605931
89FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.89203288
90SMAD4_21741376_ChIP-Seq_EPCs_Human0.88619836
91FOXH1_21741376_ChIP-Seq_EPCs_Human0.87430845
92FOXA1_27270436_Chip-Seq_PROSTATE_Human0.87186298
93FOXA1_25329375_ChIP-Seq_VCAP_Human0.87186298
94POU5F1_16153702_ChIP-ChIP_HESCs_Human0.86854660
95TOP2B_26459242_ChIP-Seq_MCF-7_Human0.86535215
96* STAT3_23295773_ChIP-Seq_U87_Human0.84993752
97DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.83740425
98CBX2_27304074_Chip-Seq_ESCs_Mouse0.83517775
99TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.82347614
100KLF5_20875108_ChIP-Seq_MESCs_Mouse0.82222308
101BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.81705667
102RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.81293057
103FLI1_27457419_Chip-Seq_LIVER_Mouse0.80671443
104POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.79866300
105TCF4_23295773_ChIP-Seq_U87_Human0.78975263
106HTT_18923047_ChIP-ChIP_STHdh_Human0.75865054
107TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.75660766
108CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.72717954
109E2F1_17053090_ChIP-ChIP_MCF-7_Human0.72621961
110PKCTHETA_26484144_Chip-Seq_BREAST_Human0.71426371
111* EWS_26573619_Chip-Seq_HEK293_Human0.71357000
112HOXB7_26014856_ChIP-Seq_BT474_Human0.69847686
113TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.69736854
114SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.69407714
115CHD1_26751641_Chip-Seq_LNCaP_Human0.68478053
116SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.68338290
117ELK1_19687146_ChIP-ChIP_HELA_Human0.67544277
118HOXB4_20404135_ChIP-ChIP_EML_Mouse0.66586997
119* GATA3_21867929_ChIP-Seq_TH1_Mouse0.64162455
120* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.63832442
121KAP1_22055183_ChIP-Seq_ESCs_Mouse0.63096086
122YY1_21170310_ChIP-Seq_MESCs_Mouse0.63000026
123NANOG_21062744_ChIP-ChIP_HESCs_Human0.62413675
124HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.62278915
125ESR1_15608294_ChIP-ChIP_MCF-7_Human0.61260525
126ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.60927051
127ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.60404878
128FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.60339009
129CDX2_22108803_ChIP-Seq_LS180_Human0.59519280
130* SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.59041982
131GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.58453507
132LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.58224188
133CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.57953030
134RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.57820758
135PCGF2_27294783_Chip-Seq_ESCs_Mouse0.57693202

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008995_early_reproductive_senescence5.91531669
2* MP0002210_abnormal_sex_determination4.43883167
3MP0010094_abnormal_chromosome_stability4.27420177
4MP0010368_abnormal_lymphatic_system4.06328879
5MP0003786_premature_aging3.90335450
6* MP0001929_abnormal_gametogenesis3.80356387
7MP0008057_abnormal_DNA_replication3.67535889
8MP0008058_abnormal_DNA_repair3.57457598
9* MP0001145_abnormal_male_reproductive3.54220945
10MP0003123_paternal_imprinting3.51110043
11* MP0000653_abnormal_sex_gland3.32326142
12MP0003111_abnormal_nucleus_morphology3.20580268
13* MP0003698_abnormal_male_reproductive2.83144380
14MP0003693_abnormal_embryo_hatching2.76901001
15MP0003077_abnormal_cell_cycle2.75511685
16MP0004957_abnormal_blastocyst_morpholog2.74013365
17MP0010030_abnormal_orbit_morphology2.13990550
18MP0003121_genomic_imprinting2.01085285
19MP0008007_abnormal_cellular_replicative2.00235078
20MP0008877_abnormal_DNA_methylation10.3481373
21* MP0001119_abnormal_female_reproductive1.83971032
22* MP0002161_abnormal_fertility/fecundity1.81819703
23MP0008932_abnormal_embryonic_tissue1.77135567
24MP0001730_embryonic_growth_arrest1.76292164
25MP0003183_abnormal_peptide_metabolism1.72663656
26MP0003787_abnormal_imprinting1.70801356
27MP0003890_abnormal_embryonic-extraembry1.68629604
28MP0000678_abnormal_parathyroid_gland1.66721141
29MP0005174_abnormal_tail_pigmentation1.61935943
30MP0003718_maternal_effect1.59738190
31MP0000350_abnormal_cell_proliferation1.54711588
32MP0001188_hyperpigmentation1.51587844
33MP0010352_gastrointestinal_tract_polyps1.48998959
34MP0008789_abnormal_olfactory_epithelium1.44539581
35MP0010307_abnormal_tumor_latency1.44189328
36* MP0003699_abnormal_female_reproductive1.39986552
37MP0002160_abnormal_reproductive_system1.25083111
38MP0004808_abnormal_hematopoietic_stem1.25080099
39MP0001879_abnormal_lymphatic_vessel1.20969591
40MP0008004_abnormal_stomach_pH1.16104078
41MP0001697_abnormal_embryo_size1.15609454
42MP0002085_abnormal_embryonic_tissue1.15159209
43MP0001672_abnormal_embryogenesis/_devel1.08909498
44MP0005380_embryogenesis_phenotype1.08909498
45MP0002084_abnormal_developmental_patter1.06373369
46MP0005410_abnormal_fertilization1.02555185
47MP0004197_abnormal_fetal_growth/weight/1.00705195
48MP0005647_abnormal_sex_gland0.99850592
49MP0005076_abnormal_cell_differentiation0.99410503
50MP0003315_abnormal_perineum_morphology0.97551251
51MP0000313_abnormal_cell_death0.94966417
52MP0003984_embryonic_growth_retardation0.94741462
53MP0003646_muscle_fatigue0.93846187
54MP0009672_abnormal_birth_weight0.93660761
55MP0002019_abnormal_tumor_incidence0.92930206
56MP0005377_hearing/vestibular/ear_phenot0.91510231
57MP0003878_abnormal_ear_physiology0.91510231
58MP0005499_abnormal_olfactory_system0.88914093
59MP0005394_taste/olfaction_phenotype0.88914093
60MP0002088_abnormal_embryonic_growth/wei0.88128035
61MP0004147_increased_porphyrin_level0.86067075
62MP0003937_abnormal_limbs/digits/tail_de0.85476429
63MP0002080_prenatal_lethality0.85058242
64MP0002095_abnormal_skin_pigmentation0.84991929
65MP0001661_extended_life_span0.83161934
66MP0000427_abnormal_hair_cycle0.82110693
67MP0003936_abnormal_reproductive_system0.81882991
68MP0000015_abnormal_ear_pigmentation0.80573940
69MP0002086_abnormal_extraembryonic_tissu0.78090841
70MP0001915_intracranial_hemorrhage0.77659736
71MP0000358_abnormal_cell_content/0.76041203
72MP0003941_abnormal_skin_development0.75682987
73MP0006292_abnormal_olfactory_placode0.75329373
74MP0005389_reproductive_system_phenotype0.74865446
75MP0002653_abnormal_ependyma_morphology0.71963194
76MP0002796_impaired_skin_barrier0.69494397
77MP0006035_abnormal_mitochondrial_morpho0.66958365
78MP0003950_abnormal_plasma_membrane0.66381442
79MP0009250_abnormal_appendicular_skeleto0.66021052
80MP0005395_other_phenotype0.64920243
81MP0005409_darkened_coat_color0.63589268
82MP0004215_abnormal_myocardial_fiber0.62765322
83MP0009703_decreased_birth_body0.62181108
84MP0009697_abnormal_copulation0.61246409
85MP0000490_abnormal_crypts_of0.59773611
86MP0005621_abnormal_cell_physiology0.59736831
87MP0009379_abnormal_foot_pigmentation0.59429933
88MP0004185_abnormal_adipocyte_glucose0.58549118
89MP0003119_abnormal_digestive_system0.56337078
90MP0005451_abnormal_body_composition0.54827091
91MP0000569_abnormal_digit_pigmentation0.54564980
92MP0005384_cellular_phenotype0.51784661
93MP0002139_abnormal_hepatobiliary_system0.51662322
94MP0003567_abnormal_fetal_cardiomyocyte0.50206831
95MP0005623_abnormal_meninges_morphology0.49348582
96MP0003861_abnormal_nervous_system0.48712353
97MP0005501_abnormal_skin_physiology0.47292955
98MP0000462_abnormal_digestive_system0.47286634
99MP0000631_abnormal_neuroendocrine_gland0.46085947
100MP0005075_abnormal_melanosome_morpholog0.44582840
101MP0000647_abnormal_sebaceous_gland0.43971842
102MP0003221_abnormal_cardiomyocyte_apopto0.43292284
103MP0005058_abnormal_lysosome_morphology0.43236750
104MP0000537_abnormal_urethra_morphology0.42768789
105MP0003115_abnormal_respiratory_system0.42230176
106MP0001293_anophthalmia0.42227256
107MP0010234_abnormal_vibrissa_follicle0.41857094
108MP0008260_abnormal_autophagy0.41447978
109MP0000566_synostosis0.41429775
110MP0002102_abnormal_ear_morphology0.41156640
111MP0001666_abnormal_nutrient_absorption0.39595092
112MP0000579_abnormal_nail_morphology0.38338652
113MP0003755_abnormal_palate_morphology0.37601760
114MP0003632_abnormal_nervous_system0.36146636
115MP0003705_abnormal_hypodermis_morpholog0.34693652
116MP0002009_preneoplasia0.33839253
117MP0010678_abnormal_skin_adnexa0.33521290
118MP0003943_abnormal_hepatobiliary_system0.33165897
119MP0002269_muscular_atrophy0.33044768
120MP0000432_abnormal_head_morphology0.32452705
121MP0002075_abnormal_coat/hair_pigmentati0.32265880
122MP0000383_abnormal_hair_follicle0.31969170
123MP0004233_abnormal_muscle_weight0.30485527
124MP0002697_abnormal_eye_size0.30393929
125MP0005408_hypopigmentation0.29504847
126MP0001727_abnormal_embryo_implantation0.28816954
127MP0002092_abnormal_eye_morphology0.28655464
128MP0001177_atelectasis0.27551903
129MP0000703_abnormal_thymus_morphology0.26699769
130MP0000639_abnormal_adrenal_gland0.26425038
131MP0003935_abnormal_craniofacial_develop0.25925694
132MP0002396_abnormal_hematopoietic_system0.25676313
133MP0002233_abnormal_nose_morphology0.25130017
134MP0002114_abnormal_axial_skeleton0.24811892

Predicted human phenotypes

RankGene SetZ-score
1Azoospermia (HP:0000027)9.75502594
2Abnormal spermatogenesis (HP:0008669)8.41948848
3Chromsome breakage (HP:0040012)5.28243004
4Gonadotropin excess (HP:0000837)5.22658486
5Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.19617605
6Degeneration of the lateral corticospinal tracts (HP:0002314)5.19617605
7Abnormality of the lower motor neuron (HP:0002366)5.11910678
8Chromosomal breakage induced by crosslinking agents (HP:0003221)4.84512793
9Osteomalacia (HP:0002749)4.60249598
10Facial hemangioma (HP:0000329)4.35711779
11Papillary thyroid carcinoma (HP:0002895)4.33372011
12Abnormality of the corticospinal tract (HP:0002492)4.28584159
13Abnormality of the labia minora (HP:0012880)3.85012782
14Scotoma (HP:0000575)3.56244326
15Male infertility (HP:0003251)3.52761218
16Tubulointerstitial nephritis (HP:0001970)3.49928307
17Horizontal nystagmus (HP:0000666)3.36155596
18Rimmed vacuoles (HP:0003805)3.33343205
1911 pairs of ribs (HP:0000878)3.31276630
20Abnormality of chromosome stability (HP:0003220)3.29754631
21Shoulder girdle muscle weakness (HP:0003547)3.24468361
22Capillary hemangiomas (HP:0005306)3.16917789
23Spontaneous abortion (HP:0005268)3.09615240
24Ectopic kidney (HP:0000086)3.09243133
25Carpal bone hypoplasia (HP:0001498)2.99912938
26Rhabdomyosarcoma (HP:0002859)2.98280572
27Shawl scrotum (HP:0000049)2.96550102
28Colon cancer (HP:0003003)2.95204926
29Amyotrophic lateral sclerosis (HP:0007354)2.95106356
30Supernumerary spleens (HP:0009799)2.91507188
31Impaired vibration sensation in the lower limbs (HP:0002166)2.85338041
32Medulloblastoma (HP:0002885)2.84031970
33Breast hypoplasia (HP:0003187)2.78925331
34Upper motor neuron abnormality (HP:0002127)2.77567348
35Meckel diverticulum (HP:0002245)2.75177505
36Birth length less than 3rd percentile (HP:0003561)2.73325860
37Absent thumb (HP:0009777)2.71762602
38Impulsivity (HP:0100710)2.71238378
39Thyroid carcinoma (HP:0002890)2.69057381
40Aplasia/Hypoplasia of the uvula (HP:0010293)2.65811354
41Ankle contracture (HP:0006466)2.61508236
42Sandal gap (HP:0001852)2.61470849
43Absent radius (HP:0003974)2.55245353
44Ependymoma (HP:0002888)2.54768030
45Abnormality of the ileum (HP:0001549)2.54427137
46Oligodactyly (HP:0012165)2.51693092
47Patellar aplasia (HP:0006443)2.48608774
48Pelvic girdle muscle weakness (HP:0003749)2.48402729
49Abnormality of the preputium (HP:0100587)2.47313084
50Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.46086960
51Volvulus (HP:0002580)2.44465506
52Abnormal lung lobation (HP:0002101)2.43675698
53Aplasia involving forearm bones (HP:0009822)2.43597751
54Absent forearm bone (HP:0003953)2.43597751
55Duplicated collecting system (HP:0000081)2.43379800
56Delayed epiphyseal ossification (HP:0002663)2.41851414
57Selective tooth agenesis (HP:0001592)2.41633804
58Abnormality of the fingertips (HP:0001211)2.40712277
59Duodenal stenosis (HP:0100867)2.37412114
60Small intestinal stenosis (HP:0012848)2.37412114
61Metaphyseal cupping (HP:0003021)2.37323391
62Oligodactyly (hands) (HP:0001180)2.34607972
63Neoplasm of striated muscle (HP:0009728)2.33107729
64Median cleft lip (HP:0000161)2.31374411
65Hyperglycinuria (HP:0003108)2.30098223
66Short thumb (HP:0009778)2.28331888
67Abnormality of chromosome segregation (HP:0002916)2.23784506
68Microglossia (HP:0000171)2.23119747
69Fibular hypoplasia (HP:0003038)2.21874332
70Aplasia/Hypoplasia of the patella (HP:0006498)2.21658233
71Astrocytoma (HP:0009592)2.21031343
72Abnormality of the astrocytes (HP:0100707)2.21031343
73Atrophy/Degeneration involving motor neurons (HP:0007373)2.18793700
74Short tibia (HP:0005736)2.18057315
75Hand muscle atrophy (HP:0009130)2.14692259
76Nephroblastoma (Wilms tumor) (HP:0002667)2.14109728
77Abnormal biliary tract morphology (HP:0012440)2.13924722
78Biliary tract neoplasm (HP:0100574)2.12780602
79Duplication of thumb phalanx (HP:0009942)2.12687378
80Heterotopia (HP:0002282)2.12338927
81Lip pit (HP:0100267)2.12283796
82Abnormality of the aortic arch (HP:0012303)2.12246507
83Cafe-au-lait spot (HP:0000957)2.10056882
84Abnormality of the costochondral junction (HP:0000919)2.09449087
85Abnormality of the phalanges of the hallux (HP:0010057)2.09252207
86Urinary urgency (HP:0000012)2.08568769
87Abnormality of the anterior horn cell (HP:0006802)2.08323175
88Degeneration of anterior horn cells (HP:0002398)2.08323175
89Abnormality of the musculature of the pelvis (HP:0001469)2.06841399
90Abnormality of the hip-girdle musculature (HP:0001445)2.06841399
91Horseshoe kidney (HP:0000085)2.06074936
92Hyperglycinemia (HP:0002154)2.05999918
93Broad distal phalanx of finger (HP:0009836)2.05874019
94Male pseudohermaphroditism (HP:0000037)2.04814313
95Premature ovarian failure (HP:0008209)2.04398904
96Increased nuchal translucency (HP:0010880)2.01635165
97Abnormality of the carotid arteries (HP:0005344)1.97560150
98Neoplasm of the colon (HP:0100273)1.97140526
99Abnormality of the renal collecting system (HP:0004742)1.97097811
100Missing ribs (HP:0000921)1.96819204
101Glioma (HP:0009733)1.95263467
102Truncal obesity (HP:0001956)1.94721419
103Embryonal renal neoplasm (HP:0011794)1.93925977
104Fair hair (HP:0002286)1.92244582
105Aplasia/Hypoplasia of the tibia (HP:0005772)1.91670583
106Broad palm (HP:0001169)1.90444302
107Basal cell carcinoma (HP:0002671)1.89451052
108Neoplasm of the oral cavity (HP:0100649)1.89100611
109Abdominal situs inversus (HP:0003363)1.87537575
110Abnormality of abdominal situs (HP:0011620)1.87537575
111Limb-girdle muscle weakness (HP:0003325)1.86872236
112Infertility (HP:0000789)1.85659049
113Rickets (HP:0002748)1.85368636
114Abnormality of DNA repair (HP:0003254)1.84805693
115Long eyelashes (HP:0000527)1.84784293
116Anteriorly placed anus (HP:0001545)1.84732612
117Facial cleft (HP:0002006)1.84269862
118Abnormality of serine family amino acid metabolism (HP:0010894)1.83016252
119Abnormality of glycine metabolism (HP:0010895)1.83016252
120Wrist flexion contracture (HP:0001239)1.82952977
121Abnormality of the duodenum (HP:0002246)1.81934213
122Reticulocytopenia (HP:0001896)1.80124035
123Sloping forehead (HP:0000340)1.78696259
124Proximal placement of thumb (HP:0009623)1.78168289
125Aplasia/Hypoplasia of the earlobes (HP:0009906)1.76274230
126Menstrual irregularities (HP:0000858)1.75967433
127Metaphyseal irregularity (HP:0003025)1.75916630
128Leiomyosarcoma (HP:0100243)1.75811311
129Uterine leiomyosarcoma (HP:0002891)1.75811311
130Urinary bladder sphincter dysfunction (HP:0002839)1.75397020
131Retinal dysplasia (HP:0007973)1.73279596
132Proximal tubulopathy (HP:0000114)1.73062645
133Embryonal neoplasm (HP:0002898)1.71841772
134Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.71477479
135Aplasia/Hypoplasia of the sternum (HP:0006714)1.71449987
136Agnosia (HP:0010524)1.70694182
137Hyperpituitarism (HP:0010514)1.70543317
138Clubbing of toes (HP:0100760)1.68188659
139Non-midline cleft lip (HP:0100335)1.64138891

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B7.35692351
2PNCK6.75496715
3CDC76.40978947
4CDK195.88377300
5CDK124.78655601
6WEE12.61634969
7NEK22.56841609
8TTK2.36422666
9MET2.25973665
10PLK42.25144761
11PLK12.16453298
12MAP3K132.13307710
13BRSK21.98304518
14STK38L1.96929773
15PDK31.94442796
16PDK41.94442796
17BRD41.83947002
18MAP3K41.80290745
19NEK91.78322333
20MAP3K61.76875316
21PBK1.71553447
22PRKD31.69879328
23STK391.68692978
24MELK1.67602574
25ARAF1.67517840
26ATR1.64619747
27CHEK11.61618140
28NEK61.41680089
29CHEK21.40778170
30NEK11.36677063
31ATM1.34263427
32BRSK11.33652911
33WNK11.32637600
34WNK41.31725988
35BUB11.31568957
36CDK81.29287751
37CAMK1G1.27645839
38NTRK31.24274282
39CDK71.23789205
40OXSR11.19697892
41STK31.18680176
42ZAK1.17693881
43MKNK21.17584994
44STK161.15529532
45CDK91.15093468
46KSR21.11235504
47EPHA41.11098595
48STK241.10767389
49TYRO31.08999458
50PLK31.08014758
51BMPR1B1.05049207
52CDK41.01235507
53KSR11.00143662
54AURKB0.99187814
55TAF10.94738484
56PDK20.91610455
57CDK20.90309946
58LATS10.89322539
59PLK20.86421181
60MAP3K90.86045002
61LATS20.83920025
62CDK10.83822130
63TGFBR10.83292060
64EIF2AK30.83174435
65SRPK10.81373181
66MST1R0.76999607
67MATK0.75501027
68MUSK0.74550031
69TIE10.72973855
70MAP3K20.71631892
71DYRK30.70205300
72STK40.69353173
73STK380.69148336
74AURKA0.67332184
75MKNK10.66594454
76CDC42BPA0.64681559
77BRAF0.63742284
78MOS0.63555990
79CCNB10.63480066
80BMPR20.63237694
81EEF2K0.63010044
82SCYL20.58834243
83EIF2AK10.56902952
84MTOR0.56331400
85CDK30.51878064
86MAP2K40.51387006
87PRKDC0.51369094
88PDGFRB0.51171008
89VRK10.49482112
90RET0.49033343
91BCR0.48658154
92EGFR0.47413007
93MAP2K70.47204961
94CSF1R0.46633985
95KIT0.46580294
96MAPK110.46551459
97GSK3B0.45913271
98SGK10.44945454
99ICK0.44337613
100CSNK1G10.43465831
101YES10.43182585
102MAP3K10.42262159
103PKN20.42253993
104CSNK1D0.42077870
105FGR0.41079790
106RAF10.39864322
107CDK11A0.39537949
108CLK10.39215770
109DYRK1A0.39125628
110TAOK10.38813368
111WNK30.38398121
112PTK20.37665814
113AKT30.37512326
114ERBB40.36923785
115CSNK1E0.36486294
116BMX0.35393235
117MAP3K80.35016733
118TAOK30.34432395
119CSNK1A1L0.34229605
120MAPK140.34065868
121MAPK80.32575032
122PASK0.31469020
123CSNK2A20.31232865
124PIM10.31015762
125CHUK0.28343364
126PINK10.27959572
127TRIM280.27453952
128PRKG10.26089781
129MAPKAPK30.25745266
130CAMK1D0.25559975
131MAPK100.25172263
132AKT10.24941380
133MARK30.24762258
134RPS6KA10.24757525
135RPS6KB10.24726434
136PRKCI0.24181361
137RPS6KB20.23997471
138CSNK1G20.23610105
139PTK2B0.22539201
140TSSK60.22461431
141NLK0.22147797
142CSNK2A10.22031552
143CSNK1G30.21732796

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030085.25178815
2Basal transcription factors_Homo sapiens_hsa030224.94074648
3Homologous recombination_Homo sapiens_hsa034404.09078096
4Mismatch repair_Homo sapiens_hsa034303.85136501
5DNA replication_Homo sapiens_hsa030303.84393259
6Cell cycle_Homo sapiens_hsa041103.69593803
7RNA transport_Homo sapiens_hsa030133.31427549
8Fanconi anemia pathway_Homo sapiens_hsa034603.15602008
9mRNA surveillance pathway_Homo sapiens_hsa030153.00552964
10Nucleotide excision repair_Homo sapiens_hsa034202.72719743
11Non-homologous end-joining_Homo sapiens_hsa034502.67054885
12RNA polymerase_Homo sapiens_hsa030202.65109758
13RNA degradation_Homo sapiens_hsa030182.56490399
14Spliceosome_Homo sapiens_hsa030402.56208662
15Base excision repair_Homo sapiens_hsa034102.39696308
16Oocyte meiosis_Homo sapiens_hsa041142.36654745
17Regulation of autophagy_Homo sapiens_hsa041402.02703727
18Ubiquitin mediated proteolysis_Homo sapiens_hsa041202.02263159
19Dorso-ventral axis formation_Homo sapiens_hsa043201.95449821
20Proteasome_Homo sapiens_hsa030501.80934134
21Selenocompound metabolism_Homo sapiens_hsa004501.69066677
22One carbon pool by folate_Homo sapiens_hsa006701.68589106
23Propanoate metabolism_Homo sapiens_hsa006401.68369768
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.67476461
25Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.61638439
26Folate biosynthesis_Homo sapiens_hsa007901.46834184
27p53 signaling pathway_Homo sapiens_hsa041151.39213123
28Pyrimidine metabolism_Homo sapiens_hsa002401.32124308
29Sulfur relay system_Homo sapiens_hsa041221.30850848
30Herpes simplex infection_Homo sapiens_hsa051681.29474970
31Lysine degradation_Homo sapiens_hsa003101.21985957
32Thyroid cancer_Homo sapiens_hsa052161.21114923
33TGF-beta signaling pathway_Homo sapiens_hsa043501.15606910
34Fatty acid elongation_Homo sapiens_hsa000621.10747842
35Epstein-Barr virus infection_Homo sapiens_hsa051691.04135602
36Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.93353147
37Purine metabolism_Homo sapiens_hsa002300.93343978
38HTLV-I infection_Homo sapiens_hsa051660.87237723
39beta-Alanine metabolism_Homo sapiens_hsa004100.86651459
40MicroRNAs in cancer_Homo sapiens_hsa052060.78508027
41ABC transporters_Homo sapiens_hsa020100.78215463
42Cyanoamino acid metabolism_Homo sapiens_hsa004600.71405747
43Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.70564566
44Pancreatic cancer_Homo sapiens_hsa052120.68317691
45Influenza A_Homo sapiens_hsa051640.67599117
46Steroid biosynthesis_Homo sapiens_hsa001000.67562094
47SNARE interactions in vesicular transport_Homo sapiens_hsa041300.64374154
48Protein export_Homo sapiens_hsa030600.63811202
49Viral carcinogenesis_Homo sapiens_hsa052030.62494251
50Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.61406356
51Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60448191
52Circadian rhythm_Homo sapiens_hsa047100.60257261
53Linoleic acid metabolism_Homo sapiens_hsa005910.60022656
54Adherens junction_Homo sapiens_hsa045200.58903045
55Hippo signaling pathway_Homo sapiens_hsa043900.58235672
56Notch signaling pathway_Homo sapiens_hsa043300.57197525
57N-Glycan biosynthesis_Homo sapiens_hsa005100.56766369
58Ribosome_Homo sapiens_hsa030100.56551060
59Colorectal cancer_Homo sapiens_hsa052100.55955970
60Cysteine and methionine metabolism_Homo sapiens_hsa002700.54738724
61Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.54584008
62alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.54097540
63FoxO signaling pathway_Homo sapiens_hsa040680.52336844
64Ovarian steroidogenesis_Homo sapiens_hsa049130.50191979
65Small cell lung cancer_Homo sapiens_hsa052220.46785015
66Caffeine metabolism_Homo sapiens_hsa002320.45990476
67Glycerolipid metabolism_Homo sapiens_hsa005610.43669256
68Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.43597372
69Fatty acid metabolism_Homo sapiens_hsa012120.41325061
70Huntingtons disease_Homo sapiens_hsa050160.39708978
71Tight junction_Homo sapiens_hsa045300.39483965
72Fatty acid degradation_Homo sapiens_hsa000710.39378440
73Transcriptional misregulation in cancer_Homo sapiens_hsa052020.38194477
74Ether lipid metabolism_Homo sapiens_hsa005650.38174966
75Gap junction_Homo sapiens_hsa045400.35275872
76Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.33691827
77Glycosaminoglycan degradation_Homo sapiens_hsa005310.33494764
78Olfactory transduction_Homo sapiens_hsa047400.31445046
79Renal cell carcinoma_Homo sapiens_hsa052110.29906159
80Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.28674204
81Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.28587465
82Prostate cancer_Homo sapiens_hsa052150.26053051
83Pathways in cancer_Homo sapiens_hsa052000.24375906
84mTOR signaling pathway_Homo sapiens_hsa041500.23581669
85Vitamin B6 metabolism_Homo sapiens_hsa007500.21599170
86Wnt signaling pathway_Homo sapiens_hsa043100.21394355
87Phototransduction_Homo sapiens_hsa047440.20905889
88Glycerophospholipid metabolism_Homo sapiens_hsa005640.19012054
89Melanoma_Homo sapiens_hsa052180.19008186
90Biosynthesis of amino acids_Homo sapiens_hsa012300.18432541
91Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.18345186
92Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.17104132
93Pentose phosphate pathway_Homo sapiens_hsa000300.17007434
94Pyruvate metabolism_Homo sapiens_hsa006200.16918987
95Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.16711916
96Type II diabetes mellitus_Homo sapiens_hsa049300.16185498
97Glucagon signaling pathway_Homo sapiens_hsa049220.16080731
98Non-small cell lung cancer_Homo sapiens_hsa052230.15960540
99Long-term depression_Homo sapiens_hsa047300.14956494
100Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.14501557
101Prion diseases_Homo sapiens_hsa050200.14486615
102Hedgehog signaling pathway_Homo sapiens_hsa043400.13915337
103Retinol metabolism_Homo sapiens_hsa008300.13563290
104VEGF signaling pathway_Homo sapiens_hsa043700.13437359
105Endocytosis_Homo sapiens_hsa041440.12252773
106Prolactin signaling pathway_Homo sapiens_hsa049170.12017698
107Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.11651232
108Basal cell carcinoma_Homo sapiens_hsa052170.11251685
109Drug metabolism - other enzymes_Homo sapiens_hsa009830.11214286
110Nicotine addiction_Homo sapiens_hsa050330.10982706
111Long-term potentiation_Homo sapiens_hsa047200.10655576
112Fatty acid biosynthesis_Homo sapiens_hsa000610.10644276
113Antigen processing and presentation_Homo sapiens_hsa046120.10336664
114cGMP-PKG signaling pathway_Homo sapiens_hsa040220.10326050
115Choline metabolism in cancer_Homo sapiens_hsa052310.10178398
116Protein digestion and absorption_Homo sapiens_hsa049740.09462448
117Endometrial cancer_Homo sapiens_hsa052130.09448070
118PI3K-Akt signaling pathway_Homo sapiens_hsa041510.09065342
119Longevity regulating pathway - mammal_Homo sapiens_hsa042110.08727308
120Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.07570272
121Metabolic pathways_Homo sapiens_hsa011000.06049560
122NOD-like receptor signaling pathway_Homo sapiens_hsa046210.05639267
123Central carbon metabolism in cancer_Homo sapiens_hsa052300.04986774
124AMPK signaling pathway_Homo sapiens_hsa041520.04299022
125Glioma_Homo sapiens_hsa052140.04133371
126Glutathione metabolism_Homo sapiens_hsa004800.01577319
127Phosphatidylinositol signaling system_Homo sapiens_hsa040700.01200424
128Glycine, serine and threonine metabolism_Homo sapiens_hsa00260-0.0545503
129Hepatitis B_Homo sapiens_hsa05161-0.0502766
130Shigellosis_Homo sapiens_hsa05131-0.0449684
131Fc epsilon RI signaling pathway_Homo sapiens_hsa04664-0.0412947
132HIF-1 signaling pathway_Homo sapiens_hsa04066-0.0288945
133Inositol phosphate metabolism_Homo sapiens_hsa00562-0.0288800
134ErbB signaling pathway_Homo sapiens_hsa04012-0.0213245
135Ras signaling pathway_Homo sapiens_hsa04014-0.0161175
136Estrogen signaling pathway_Homo sapiens_hsa04915-0.0159148
137Sphingolipid signaling pathway_Homo sapiens_hsa04071-0.0118670
138GnRH signaling pathway_Homo sapiens_hsa04912-0.0112209
139Systemic lupus erythematosus_Homo sapiens_hsa05322-0.0062686

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