

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | mitotic metaphase plate congression (GO:0007080) | 5.57244925 |
| 2 | protein localization to kinetochore (GO:0034501) | 5.15182815 |
| 3 | nuclear pore organization (GO:0006999) | 4.88449450 |
| 4 | metaphase plate congression (GO:0051310) | 4.86593465 |
| 5 | nuclear pore complex assembly (GO:0051292) | 4.86244349 |
| 6 | regulation of attachment of spindle microtubules to kinetochore (GO:0051988) | 4.78144710 |
| 7 | protein localization to chromosome, centromeric region (GO:0071459) | 4.71571890 |
| 8 | mitotic chromosome condensation (GO:0007076) | 4.64506173 |
| 9 | mitotic sister chromatid segregation (GO:0000070) | 4.59623442 |
| 10 | kinetochore organization (GO:0051383) | 4.58655870 |
| 11 | establishment of integrated proviral latency (GO:0075713) | 4.46261022 |
| 12 | DNA topological change (GO:0006265) | 4.45808990 |
| 13 | regulation of spindle organization (GO:0090224) | 4.42337684 |
| 14 | DNA ligation (GO:0006266) | 4.39862166 |
| 15 | establishment of chromosome localization (GO:0051303) | 4.38999813 |
| 16 | sister chromatid segregation (GO:0000819) | 4.28060394 |
| 17 | chromatin remodeling at centromere (GO:0031055) | 4.26070365 |
| 18 | mitotic nuclear envelope disassembly (GO:0007077) | 4.26054459 |
| 19 | meiotic chromosome segregation (GO:0045132) | 4.25843253 |
| 20 | CENP-A containing nucleosome assembly (GO:0034080) | 4.20962294 |
| 21 | kinetochore assembly (GO:0051382) | 4.15573097 |
| 22 | attachment of spindle microtubules to kinetochore (GO:0008608) | 4.14341480 |
| 23 | protein K6-linked ubiquitination (GO:0085020) | 4.11527367 |
| 24 | DNA replication initiation (GO:0006270) | 4.11119255 |
| 25 | DNA replication checkpoint (GO:0000076) | 4.07366532 |
| 26 | DNA double-strand break processing (GO:0000729) | 4.00434495 |
| 27 | nuclear envelope disassembly (GO:0051081) | 3.95606023 |
| 28 | membrane disassembly (GO:0030397) | 3.95606023 |
| 29 | DNA replication-independent nucleosome organization (GO:0034724) | 3.94060282 |
| 30 | DNA replication-independent nucleosome assembly (GO:0006336) | 3.94060282 |
| 31 | positive regulation of chromosome segregation (GO:0051984) | 3.93547358 |
| 32 | regulation of mitotic spindle organization (GO:0060236) | 3.88870517 |
| 33 | DNA replication-dependent nucleosome assembly (GO:0006335) | 3.84719335 |
| 34 | DNA replication-dependent nucleosome organization (GO:0034723) | 3.84719335 |
| 35 | DNA unwinding involved in DNA replication (GO:0006268) | 3.76790944 |
| 36 | histone exchange (GO:0043486) | 3.76436579 |
| 37 | pore complex assembly (GO:0046931) | 3.74854442 |
| 38 | mitotic sister chromatid cohesion (GO:0007064) | 3.73831092 |
| 39 | protein localization to chromosome (GO:0034502) | 3.73374287 |
| 40 | spindle checkpoint (GO:0031577) | 3.72864862 |
| 41 | regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083) | 3.72716825 |
| 42 | regulation of chromosome segregation (GO:0051983) | 3.72442907 |
| 43 | positive regulation of mitotic sister chromatid separation (GO:1901970) | 3.71489569 |
| 44 | positive regulation of mitotic metaphase/anaphase transition (GO:0045842) | 3.71489569 |
| 45 | positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101) | 3.71489569 |
| 46 | mitotic G2/M transition checkpoint (GO:0044818) | 3.65624838 |
| 47 | DNA strand elongation involved in DNA replication (GO:0006271) | 3.63023699 |
| 48 | regulation of sister chromatid cohesion (GO:0007063) | 3.59012380 |
| 49 | chromosome segregation (GO:0007059) | 3.57901631 |
| 50 | proteasome assembly (GO:0043248) | 3.51447734 |
| 51 | maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005) | 3.47482356 |
| 52 | DNA strand elongation (GO:0022616) | 3.47459156 |
| 53 | regulation of mitotic spindle checkpoint (GO:1903504) | 3.47285879 |
| 54 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 3.47285879 |
| 55 | regulation of mitotic metaphase/anaphase transition (GO:0030071) | 3.47009267 |
| 56 | regulation of metaphase/anaphase transition of cell cycle (GO:1902099) | 3.45135851 |
| 57 | negative regulation of chromosome segregation (GO:0051985) | 3.45097296 |
| 58 | chromatin assembly or disassembly (GO:0006333) | 3.43803537 |
| 59 | regulation of DNA endoreduplication (GO:0032875) | 3.42032581 |
| 60 | regulation of centrosome cycle (GO:0046605) | 3.41221267 |
| 61 | mitotic spindle checkpoint (GO:0071174) | 3.41031942 |
| 62 | spindle assembly checkpoint (GO:0071173) | 3.40906064 |
| 63 | regulation of double-strand break repair via homologous recombination (GO:0010569) | 3.40716406 |
| 64 | negative regulation of mitotic sister chromatid separation (GO:2000816) | 3.39789033 |
| 65 | negative regulation of mitotic sister chromatid segregation (GO:0033048) | 3.39789033 |
| 66 | negative regulation of mitotic metaphase/anaphase transition (GO:0045841) | 3.39789033 |
| 67 | negative regulation of sister chromatid segregation (GO:0033046) | 3.39789033 |
| 68 | monoubiquitinated protein deubiquitination (GO:0035520) | 3.39018842 |
| 69 | microtubule depolymerization (GO:0007019) | 3.38477897 |
| 70 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.38438436 |
| 71 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.38322069 |
| 72 | negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100) | 3.37576972 |
| 73 | mitotic recombination (GO:0006312) | 3.36043479 |
| 74 | telomere maintenance via recombination (GO:0000722) | 3.35609623 |
| 75 | mitotic spindle assembly checkpoint (GO:0007094) | 3.32957283 |
| 76 | establishment of viral latency (GO:0019043) | 3.32522003 |
| 77 | regulation of sister chromatid segregation (GO:0033045) | 3.31989789 |
| 78 | regulation of mitotic sister chromatid separation (GO:0010965) | 3.31989789 |
| 79 | regulation of mitotic sister chromatid segregation (GO:0033047) | 3.31989789 |
| 80 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.27242998 |
| 81 | folic acid-containing compound biosynthetic process (GO:0009396) | 3.27240650 |
| 82 | negative regulation of mitosis (GO:0045839) | 3.24444829 |
| 83 | regulation of telomere maintenance via telomerase (GO:0032210) | 3.23577766 |
| 84 | maturation of 5.8S rRNA (GO:0000460) | 3.22892873 |
| 85 | non-recombinational repair (GO:0000726) | 3.20868439 |
| 86 | double-strand break repair via nonhomologous end joining (GO:0006303) | 3.20868439 |
| 87 | nucleobase biosynthetic process (GO:0046112) | 3.18733205 |
| 88 | DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla | 3.17990474 |
| 89 | regulation of centriole replication (GO:0046599) | 3.16937801 |
| 90 | DNA packaging (GO:0006323) | 3.14951696 |
| 91 | DNA geometric change (GO:0032392) | 3.14594990 |
| 92 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.14230667 |
| 93 | DNA duplex unwinding (GO:0032508) | 3.14138424 |
| 94 | DNA catabolic process, exonucleolytic (GO:0000738) | 3.12304266 |
| 95 | regulation of helicase activity (GO:0051095) | 3.12120437 |
| 96 | ribosome assembly (GO:0042255) | 3.11939833 |
| 97 | mitotic G2 DNA damage checkpoint (GO:0007095) | 3.11860297 |
| 98 | DNA damage response, signal transduction resulting in transcription (GO:0042772) | 3.11579118 |
| 99 | regulation of histone H3-K9 methylation (GO:0051570) | 3.11415401 |
| 100 | resolution of meiotic recombination intermediates (GO:0000712) | 3.11395846 |
| 101 | negative regulation of histone methylation (GO:0031061) | 3.10471093 |
| 102 | regulation of nuclear cell cycle DNA replication (GO:0033262) | 3.09701462 |
| 103 | ATP-dependent chromatin remodeling (GO:0043044) | 3.08514737 |
| 104 | histone H2A monoubiquitination (GO:0035518) | 3.08366803 |
| 105 | negative regulation of DNA-dependent DNA replication (GO:2000104) | 3.07604261 |
| 106 | nuclear envelope organization (GO:0006998) | 3.07326493 |
| 107 | synapsis (GO:0007129) | 3.07282739 |
| 108 | centriole replication (GO:0007099) | 3.06406149 |
| 109 | purine nucleobase biosynthetic process (GO:0009113) | 3.05488456 |
| 110 | IMP biosynthetic process (GO:0006188) | 3.04218679 |
| 111 | telomere maintenance via telomere lengthening (GO:0010833) | 3.04205833 |
| 112 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 3.03881459 |
| 113 | * mitotic cell cycle (GO:0000278) | 3.03706562 |
| 114 | regulation of gene silencing by RNA (GO:0060966) | 3.02887519 |
| 115 | regulation of posttranscriptional gene silencing (GO:0060147) | 3.02887519 |
| 116 | regulation of gene silencing by miRNA (GO:0060964) | 3.02887519 |
| 117 | chromosome condensation (GO:0030261) | 3.00456925 |
| 118 | replication fork processing (GO:0031297) | 2.98125963 |
| 119 | mismatch repair (GO:0006298) | 2.97720034 |
| 120 | DNA synthesis involved in DNA repair (GO:0000731) | 2.97661223 |
| 121 | heterochromatin organization (GO:0070828) | 2.96572969 |
| 122 | negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435) | 2.96316333 |
| 123 | regulation of exit from mitosis (GO:0007096) | 2.95781633 |
| 124 | regulation of double-strand break repair (GO:2000779) | 2.94780324 |
| 125 | somatic hypermutation of immunoglobulin genes (GO:0016446) | 2.91585498 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 6.37226673 |
| 2 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 4.51526171 |
| 3 | * FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 4.11658113 |
| 4 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 3.63595162 |
| 5 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 2.74342539 |
| 6 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.68108335 |
| 7 | AR_21909140_ChIP-Seq_LNCAP_Human | 2.62778458 |
| 8 | * KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 2.60998816 |
| 9 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.53588287 |
| 10 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 2.39522327 |
| 11 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 2.38602515 |
| 12 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 2.33340858 |
| 13 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 2.31072370 |
| 14 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.27182798 |
| 15 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 2.19524543 |
| 16 | * MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 2.19521662 |
| 17 | * MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.14555720 |
| 18 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 2.11454004 |
| 19 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.01285851 |
| 20 | E2F7_22180533_ChIP-Seq_HELA_Human | 10.1792493 |
| 21 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.98861819 |
| 22 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.97261931 |
| 23 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.97167690 |
| 24 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 1.95417189 |
| 25 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 1.92221213 |
| 26 | * XRN2_22483619_ChIP-Seq_HELA_Human | 1.87552416 |
| 27 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 1.87083516 |
| 28 | * NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.86848076 |
| 29 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.86456317 |
| 30 | VDR_23849224_ChIP-Seq_CD4+_Human | 1.81773664 |
| 31 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 1.78047820 |
| 32 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 1.75102426 |
| 33 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.65281353 |
| 34 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.63057767 |
| 35 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.60830288 |
| 36 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 1.60660935 |
| 37 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.60126862 |
| 38 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.56685332 |
| 39 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.50058137 |
| 40 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.49168149 |
| 41 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.48729094 |
| 42 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.46541950 |
| 43 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.44689082 |
| 44 | MYC_22102868_ChIP-Seq_BL_Human | 1.43886746 |
| 45 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.42869362 |
| 46 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.41872017 |
| 47 | EWS_26573619_Chip-Seq_HEK293_Human | 1.41175373 |
| 48 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 1.36375542 |
| 49 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.35072642 |
| 50 | * SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.33713552 |
| 51 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.32159570 |
| 52 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.28959186 |
| 53 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.28584313 |
| 54 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.28282309 |
| 55 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.27911940 |
| 56 | * POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.26662995 |
| 57 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.25125396 |
| 58 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 1.25070595 |
| 59 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 1.25070595 |
| 60 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 1.25070595 |
| 61 | * KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.22607942 |
| 62 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.18410467 |
| 63 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.16712969 |
| 64 | CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 1.15784001 |
| 65 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.15477499 |
| 66 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.15410246 |
| 67 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.11838870 |
| 68 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.11377366 |
| 69 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 1.11216955 |
| 70 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.10268282 |
| 71 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.10185948 |
| 72 | SOX2_19030024_ChIP-ChIP_MESCs_Mouse | 1.08222890 |
| 73 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 1.08046345 |
| 74 | NANOG_21062744_ChIP-ChIP_HESCs_Human | 1.07402729 |
| 75 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.06847001 |
| 76 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.06089867 |
| 77 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.04474392 |
| 78 | * TCF3_18692474_ChIP-Seq_MESCs_Mouse | 1.04111486 |
| 79 | FUS_26573619_Chip-Seq_HEK293_Human | 1.04084551 |
| 80 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.03592916 |
| 81 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.02783290 |
| 82 | * TCF3_18692474_ChIP-Seq_MEFs_Mouse | 1.02704499 |
| 83 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.02680483 |
| 84 | SALL4_18804426_ChIP-ChIP_MESCs_Mouse | 1.01685372 |
| 85 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.01588728 |
| 86 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.00004056 |
| 87 | NACC1_18358816_ChIP-ChIP_MESCs_Mouse | 0.98670624 |
| 88 | VDR_22108803_ChIP-Seq_LS180_Human | 0.97218085 |
| 89 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 0.96711703 |
| 90 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 0.96076087 |
| 91 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.95280353 |
| 92 | ZNF274_21170338_ChIP-Seq_K562_Hela | 0.94832131 |
| 93 | ZIC3_20872845_ChIP-ChIP_MESCs_Mouse | 0.94304495 |
| 94 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 0.93083992 |
| 95 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 0.92265769 |
| 96 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 0.91557888 |
| 97 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.91244148 |
| 98 | HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse | 0.86259185 |
| 99 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 0.85310381 |
| 100 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 0.85039924 |
| 101 | * NANOG_18358816_ChIP-ChIP_MESCs_Mouse | 0.84035699 |
| 102 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 0.83920382 |
| 103 | CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.83575582 |
| 104 | * PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 0.83078522 |
| 105 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 0.82089556 |
| 106 | * KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 0.80975949 |
| 107 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.80340661 |
| 108 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 0.79914615 |
| 109 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.79885219 |
| 110 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 0.76679793 |
| 111 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.76559852 |
| 112 | * SOX2_18692474_ChIP-Seq_MESCs_Mouse | 0.73486547 |
| 113 | * NANOG_18347094_ChIP-ChIP_MESCs_Mouse | 0.73087484 |
| 114 | KAP1_22055183_ChIP-Seq_ESCs_Mouse | 0.73036272 |
| 115 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 0.73017673 |
| 116 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.72423307 |
| 117 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.71799660 |
| 118 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.69628425 |
| 119 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 0.66809426 |
| 120 | * TRIM28_19339689_ChIP-ChIP_MESCs_Mouse | 0.63444866 |
| 121 | CHD1_26751641_Chip-Seq_LNCaP_Human | 0.62095437 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003693_abnormal_embryo_hatching | 5.23084516 |
| 2 | MP0003111_abnormal_nucleus_morphology | 4.64487571 |
| 3 | MP0010094_abnormal_chromosome_stability | 4.62567025 |
| 4 | MP0003077_abnormal_cell_cycle | 4.05573919 |
| 5 | MP0008057_abnormal_DNA_replication | 3.95116457 |
| 6 | MP0004957_abnormal_blastocyst_morpholog | 3.92379764 |
| 7 | MP0008058_abnormal_DNA_repair | 3.07619382 |
| 8 | MP0008007_abnormal_cellular_replicative | 3.00539879 |
| 9 | MP0010307_abnormal_tumor_latency | 2.51676464 |
| 10 | MP0003123_paternal_imprinting | 2.43421404 |
| 11 | MP0008877_abnormal_DNA_methylation | 2.38721063 |
| 12 | MP0008932_abnormal_embryonic_tissue | 2.37930103 |
| 13 | MP0009379_abnormal_foot_pigmentation | 2.36135869 |
| 14 | MP0000350_abnormal_cell_proliferation | 2.32308132 |
| 15 | MP0001730_embryonic_growth_arrest | 2.29974621 |
| 16 | MP0001188_hyperpigmentation | 2.26117946 |
| 17 | MP0009697_abnormal_copulation | 2.20837166 |
| 18 | MP0003718_maternal_effect | 2.00744075 |
| 19 | MP0010352_gastrointestinal_tract_polyps | 1.98349020 |
| 20 | MP0001672_abnormal_embryogenesis/_devel | 1.89264633 |
| 21 | MP0005380_embryogenesis_phenotype | 1.89264633 |
| 22 | MP0002396_abnormal_hematopoietic_system | 1.84369654 |
| 23 | MP0001697_abnormal_embryo_size | 1.80523198 |
| 24 | MP0002085_abnormal_embryonic_tissue | 1.76771139 |
| 25 | MP0003786_premature_aging | 1.75803164 |
| 26 | MP0002084_abnormal_developmental_patter | 1.68859487 |
| 27 | MP0005076_abnormal_cell_differentiation | 1.66367474 |
| 28 | MP0000490_abnormal_crypts_of | 1.65729571 |
| 29 | MP0003121_genomic_imprinting | 1.63784008 |
| 30 | MP0003984_embryonic_growth_retardation | 1.63117606 |
| 31 | MP0002653_abnormal_ependyma_morphology | 1.60338745 |
| 32 | MP0002088_abnormal_embryonic_growth/wei | 1.59408289 |
| 33 | MP0002086_abnormal_extraembryonic_tissu | 1.56450134 |
| 34 | MP0002080_prenatal_lethality | 1.48728032 |
| 35 | MP0001529_abnormal_vocalization | 1.48041478 |
| 36 | MP0002210_abnormal_sex_determination | 1.47262332 |
| 37 | MP0004197_abnormal_fetal_growth/weight/ | 1.42647902 |
| 38 | MP0006292_abnormal_olfactory_placode | 1.42485063 |
| 39 | MP0003890_abnormal_embryonic-extraembry | 1.36618950 |
| 40 | MP0010030_abnormal_orbit_morphology | 1.35976196 |
| 41 | MP0002019_abnormal_tumor_incidence | 1.33960704 |
| 42 | MP0004808_abnormal_hematopoietic_stem | 1.32644843 |
| 43 | MP0000313_abnormal_cell_death | 1.31175717 |
| 44 | MP0003937_abnormal_limbs/digits/tail_de | 1.29900307 |
| 45 | MP0006035_abnormal_mitochondrial_morpho | 1.29637157 |
| 46 | MP0003567_abnormal_fetal_cardiomyocyte | 1.28825652 |
| 47 | MP0002938_white_spotting | 1.26939377 |
| 48 | MP0000372_irregular_coat_pigmentation | 1.26681499 |
| 49 | MP0001929_abnormal_gametogenesis | 1.25896959 |
| 50 | MP0001145_abnormal_male_reproductive | 1.23496882 |
| 51 | MP0002102_abnormal_ear_morphology | 1.20276361 |
| 52 | MP0000647_abnormal_sebaceous_gland | 1.19940842 |
| 53 | MP0001119_abnormal_female_reproductive | 1.18410815 |
| 54 | MP0000653_abnormal_sex_gland | 1.17975376 |
| 55 | MP0001293_anophthalmia | 1.17316225 |
| 56 | MP0001545_abnormal_hematopoietic_system | 1.11998411 |
| 57 | MP0005397_hematopoietic_system_phenotyp | 1.11998411 |
| 58 | MP0003941_abnormal_skin_development | 1.10197895 |
| 59 | MP0003787_abnormal_imprinting | 1.08280234 |
| 60 | MP0009333_abnormal_splenocyte_physiolog | 0.98030285 |
| 61 | MP0006072_abnormal_retinal_apoptosis | 0.97889514 |
| 62 | MP0003315_abnormal_perineum_morphology | 0.97700864 |
| 63 | MP0003806_abnormal_nucleotide_metabolis | 0.97233530 |
| 64 | MP0005174_abnormal_tail_pigmentation | 0.92696175 |
| 65 | MP0005187_abnormal_penis_morphology | 0.91907596 |
| 66 | MP0001915_intracranial_hemorrhage | 0.91693832 |
| 67 | MP0003119_abnormal_digestive_system | 0.91052842 |
| 68 | MP0009672_abnormal_birth_weight | 0.90888368 |
| 69 | MP0009053_abnormal_anal_canal | 0.89906242 |
| 70 | MP0002009_preneoplasia | 0.88915069 |
| 71 | MP0004264_abnormal_extraembryonic_tissu | 0.88887215 |
| 72 | MP0002877_abnormal_melanocyte_morpholog | 0.88083080 |
| 73 | MP0003705_abnormal_hypodermis_morpholog | 0.88051936 |
| 74 | MP0000358_abnormal_cell_content/ | 0.87973237 |
| 75 | MP0006036_abnormal_mitochondrial_physio | 0.87573783 |
| 76 | MP0005367_renal/urinary_system_phenotyp | 0.86854045 |
| 77 | MP0000516_abnormal_urinary_system | 0.86854045 |
| 78 | MP0009703_decreased_birth_body | 0.86163453 |
| 79 | MP0000703_abnormal_thymus_morphology | 0.85895952 |
| 80 | MP0005621_abnormal_cell_physiology | 0.84901614 |
| 81 | MP0001286_abnormal_eye_development | 0.84802696 |
| 82 | MP0003699_abnormal_female_reproductive | 0.84319871 |
| 83 | MP0000537_abnormal_urethra_morphology | 0.83631724 |
| 84 | MP0000432_abnormal_head_morphology | 0.82666423 |
| 85 | MP0008789_abnormal_olfactory_epithelium | 0.82167778 |
| 86 | MP0008995_early_reproductive_senescence | 0.81882577 |
| 87 | MP0002111_abnormal_tail_morphology | 0.81729570 |
| 88 | MP0001849_ear_inflammation | 0.81569864 |
| 89 | MP0009278_abnormal_bone_marrow | 0.81537819 |
| 90 | MP0003763_abnormal_thymus_physiology | 0.80818024 |
| 91 | MP0000049_abnormal_middle_ear | 0.79688956 |
| 92 | MP0002751_abnormal_autonomic_nervous | 0.77243717 |
| 93 | MP0005384_cellular_phenotype | 0.77103146 |
| 94 | MP0003221_abnormal_cardiomyocyte_apopto | 0.76827129 |
| 95 | MP0002398_abnormal_bone_marrow | 0.76493390 |
| 96 | MP0002233_abnormal_nose_morphology | 0.76444459 |
| 97 | MP0002095_abnormal_skin_pigmentation | 0.75217625 |
| 98 | MP0003755_abnormal_palate_morphology | 0.74452264 |
| 99 | MP0000566_synostosis | 0.74236615 |
| 100 | MP0002160_abnormal_reproductive_system | 0.74120031 |
| 101 | MP0002234_abnormal_pharynx_morphology | 0.74090019 |
| 102 | MP0002092_abnormal_eye_morphology | 0.72925122 |
| 103 | MP0003186_abnormal_redox_activity | 0.72264755 |
| 104 | MP0003935_abnormal_craniofacial_develop | 0.71381281 |
| 105 | MP0000015_abnormal_ear_pigmentation | 0.71046581 |
| 106 | MP0000858_altered_metastatic_potential | 0.70855812 |
| 107 | MP0000383_abnormal_hair_follicle | 0.70121773 |
| 108 | MP0005395_other_phenotype | 0.69904540 |
| 109 | MP0000428_abnormal_craniofacial_morphol | 0.69810282 |
| 110 | MP0005389_reproductive_system_phenotype | 0.69082119 |
| 111 | MP0002722_abnormal_immune_system | 0.68463372 |
| 112 | MP0005451_abnormal_body_composition | 0.68288766 |
| 113 | MP0003136_yellow_coat_color | 0.66778059 |
| 114 | MP0005391_vision/eye_phenotype | 0.66447838 |
| 115 | MP0003566_abnormal_cell_adhesion | 0.66104226 |
| 116 | MP0000733_abnormal_muscle_development | 0.66072609 |
| 117 | MP0005023_abnormal_wound_healing | 0.65842244 |
| 118 | MP0004147_increased_porphyrin_level | 0.65069547 |
| 119 | MP0002697_abnormal_eye_size | 0.64946457 |
| 120 | MP0000689_abnormal_spleen_morphology | 0.64619474 |
| 121 | MP0000627_abnormal_mammary_gland | 0.64221211 |
| 122 | MP0002925_abnormal_cardiovascular_devel | 0.63750848 |
| 123 | MP0001727_abnormal_embryo_implantation | 0.63545726 |
| 124 | MP0003861_abnormal_nervous_system | 0.63099730 |
| 125 | MP0002177_abnormal_outer_ear | 0.62135999 |
| 126 | MP0010678_abnormal_skin_adnexa | 0.61386168 |
| 127 | MP0003448_altered_tumor_morphology | 0.61274091 |
| 128 | MP0003698_abnormal_male_reproductive | 0.60910003 |
| 129 | MP0002161_abnormal_fertility/fecundity | 0.60469299 |
| 130 | MP0003936_abnormal_reproductive_system | 0.59564327 |
| 131 | MP0005408_hypopigmentation | 0.59366800 |
| 132 | MP0003943_abnormal_hepatobiliary_system | 0.59232490 |
| 133 | MP0010234_abnormal_vibrissa_follicle | 0.58139729 |
| 134 | MP0000477_abnormal_intestine_morphology | 0.57849266 |
| 135 | MP0005394_taste/olfaction_phenotype | 0.54008284 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Chromsome breakage (HP:0040012) | 5.61221517 |
| 2 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 5.48247167 |
| 3 | Birth length less than 3rd percentile (HP:0003561) | 4.65620588 |
| 4 | Abnormality of chromosome stability (HP:0003220) | 3.96719171 |
| 5 | Meckel diverticulum (HP:0002245) | 3.69196329 |
| 6 | Breast hypoplasia (HP:0003187) | 3.67102076 |
| 7 | Cortical dysplasia (HP:0002539) | 3.61562157 |
| 8 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 3.58114932 |
| 9 | Abnormality of the preputium (HP:0100587) | 3.56601720 |
| 10 | Patellar aplasia (HP:0006443) | 3.53164626 |
| 11 | Abnormality of the ileum (HP:0001549) | 3.48964780 |
| 12 | Abnormality of the labia minora (HP:0012880) | 3.38577070 |
| 13 | Aplasia/Hypoplasia of the patella (HP:0006498) | 3.31059889 |
| 14 | Ectopic kidney (HP:0000086) | 3.13416676 |
| 15 | Impulsivity (HP:0100710) | 3.10122200 |
| 16 | Small intestinal stenosis (HP:0012848) | 3.09156274 |
| 17 | Duodenal stenosis (HP:0100867) | 3.09156274 |
| 18 | Medulloblastoma (HP:0002885) | 3.02473949 |
| 19 | Myelodysplasia (HP:0002863) | 3.01065733 |
| 20 | Facial hemangioma (HP:0000329) | 2.98998057 |
| 21 | Absent radius (HP:0003974) | 2.95566942 |
| 22 | Ependymoma (HP:0002888) | 2.94796898 |
| 23 | Selective tooth agenesis (HP:0001592) | 2.91553776 |
| 24 | Supernumerary spleens (HP:0009799) | 2.86550468 |
| 25 | Absent forearm bone (HP:0003953) | 2.76866295 |
| 26 | Aplasia involving forearm bones (HP:0009822) | 2.76866295 |
| 27 | Sloping forehead (HP:0000340) | 2.63037516 |
| 28 | Carpal bone hypoplasia (HP:0001498) | 2.62204411 |
| 29 | Abnormality of the duodenum (HP:0002246) | 2.56567181 |
| 30 | Reticulocytopenia (HP:0001896) | 2.53821990 |
| 31 | Volvulus (HP:0002580) | 2.53519630 |
| 32 | Abnormality of the carotid arteries (HP:0005344) | 2.52642336 |
| 33 | Rhabdomyosarcoma (HP:0002859) | 2.51989864 |
| 34 | Oral leukoplakia (HP:0002745) | 2.49202266 |
| 35 | Absent thumb (HP:0009777) | 2.48147164 |
| 36 | Colon cancer (HP:0003003) | 2.47382388 |
| 37 | Clubbing of toes (HP:0100760) | 2.45241618 |
| 38 | Short thumb (HP:0009778) | 2.44912338 |
| 39 | Abnormal lung lobation (HP:0002101) | 2.43583493 |
| 40 | Duplicated collecting system (HP:0000081) | 2.41409784 |
| 41 | Nephroblastoma (Wilms tumor) (HP:0002667) | 2.40527048 |
| 42 | Agnosia (HP:0010524) | 2.40037231 |
| 43 | Bone marrow hypocellularity (HP:0005528) | 2.37245948 |
| 44 | Neoplasm of the oral cavity (HP:0100649) | 2.35237725 |
| 45 | Cafe-au-lait spot (HP:0000957) | 2.30995882 |
| 46 | Acute necrotizing encephalopathy (HP:0006965) | 2.28921837 |
| 47 | Short middle phalanx of the 5th finger (HP:0004220) | 2.27644831 |
| 48 | Deviation of the thumb (HP:0009603) | 2.26065077 |
| 49 | Proximal placement of thumb (HP:0009623) | 2.24761966 |
| 50 | Increased nuchal translucency (HP:0010880) | 2.24681159 |
| 51 | Embryonal renal neoplasm (HP:0011794) | 2.23202641 |
| 52 | Acute encephalopathy (HP:0006846) | 2.22335991 |
| 53 | Capillary hemangiomas (HP:0005306) | 2.22285043 |
| 54 | Tracheoesophageal fistula (HP:0002575) | 2.20963352 |
| 55 | Abnormality of the anterior horn cell (HP:0006802) | 2.19849383 |
| 56 | Degeneration of anterior horn cells (HP:0002398) | 2.19849383 |
| 57 | Increased hepatocellular lipid droplets (HP:0006565) | 2.19577551 |
| 58 | Abnormality of the astrocytes (HP:0100707) | 2.19413604 |
| 59 | Astrocytoma (HP:0009592) | 2.19413604 |
| 60 | Abnormality of the renal collecting system (HP:0004742) | 2.18102065 |
| 61 | Prostate neoplasm (HP:0100787) | 2.18099979 |
| 62 | Neoplasm of the pancreas (HP:0002894) | 2.17750780 |
| 63 | Glioma (HP:0009733) | 2.13463021 |
| 64 | Rib fusion (HP:0000902) | 2.13024957 |
| 65 | Triphalangeal thumb (HP:0001199) | 2.11866973 |
| 66 | Prominent nose (HP:0000448) | 2.11339228 |
| 67 | Shawl scrotum (HP:0000049) | 2.11152825 |
| 68 | Squamous cell carcinoma (HP:0002860) | 2.10370374 |
| 69 | Abnormality of DNA repair (HP:0003254) | 2.09369090 |
| 70 | Abnormality of the fingertips (HP:0001211) | 2.08851905 |
| 71 | Horseshoe kidney (HP:0000085) | 2.08173624 |
| 72 | Aplasia/Hypoplasia of the sternum (HP:0006714) | 2.07174267 |
| 73 | Acute myeloid leukemia (HP:0004808) | 2.05512000 |
| 74 | Increased CSF lactate (HP:0002490) | 2.05435479 |
| 75 | Atresia of the external auditory canal (HP:0000413) | 2.03539752 |
| 76 | Rough bone trabeculation (HP:0100670) | 2.01633095 |
| 77 | Pancytopenia (HP:0001876) | 2.01194990 |
| 78 | Breast aplasia (HP:0100783) | 2.00485582 |
| 79 | Overlapping toe (HP:0001845) | 1.99877556 |
| 80 | Abnormal mitochondria in muscle tissue (HP:0008316) | 1.98603884 |
| 81 | Abnormal number of incisors (HP:0011064) | 1.98191446 |
| 82 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 1.97760331 |
| 83 | Choanal atresia (HP:0000453) | 1.94606020 |
| 84 | Oligodactyly (HP:0012165) | 1.94262167 |
| 85 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 1.94074674 |
| 86 | Pancreatic islet-cell hyperplasia (HP:0004510) | 1.93143681 |
| 87 | Basal cell carcinoma (HP:0002671) | 1.92726775 |
| 88 | Aplastic anemia (HP:0001915) | 1.92214436 |
| 89 | Papillary thyroid carcinoma (HP:0002895) | 1.91860315 |
| 90 | Embryonal neoplasm (HP:0002898) | 1.90517820 |
| 91 | Biliary tract neoplasm (HP:0100574) | 1.89043051 |
| 92 | Neoplasm of striated muscle (HP:0009728) | 1.88710182 |
| 93 | Aplasia/Hypoplasia of the breasts (HP:0010311) | 1.88558294 |
| 94 | Lipid accumulation in hepatocytes (HP:0006561) | 1.87092586 |
| 95 | Abdominal situs inversus (HP:0003363) | 1.86080378 |
| 96 | Abnormality of abdominal situs (HP:0011620) | 1.86080378 |
| 97 | Premature graying of hair (HP:0002216) | 1.85631216 |
| 98 | Progressive macrocephaly (HP:0004481) | 1.83646558 |
| 99 | Arteriovenous malformation (HP:0100026) | 1.83485306 |
| 100 | Aplasia/hypoplasia of the humerus (HP:0006507) | 1.82504826 |
| 101 | Mitochondrial inheritance (HP:0001427) | 1.82067493 |
| 102 | Short 4th metacarpal (HP:0010044) | 1.81721139 |
| 103 | Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042) | 1.81721139 |
| 104 | Macrocytic anemia (HP:0001972) | 1.81445385 |
| 105 | Abnormality of the septum pellucidum (HP:0007375) | 1.81428839 |
| 106 | Long eyelashes (HP:0000527) | 1.81197566 |
| 107 | Microvesicular hepatic steatosis (HP:0001414) | 1.80879385 |
| 108 | Septo-optic dysplasia (HP:0100842) | 1.80224762 |
| 109 | Abnormality of methionine metabolism (HP:0010901) | 1.79799397 |
| 110 | Cerebral edema (HP:0002181) | 1.79582777 |
| 111 | Amaurosis fugax (HP:0100576) | 1.79539938 |
| 112 | Abnormality of chromosome segregation (HP:0002916) | 1.78823130 |
| 113 | 11 pairs of ribs (HP:0000878) | 1.78443687 |
| 114 | Sandal gap (HP:0001852) | 1.78426929 |
| 115 | Abnormal spermatogenesis (HP:0008669) | 1.76552015 |
| 116 | High pitched voice (HP:0001620) | 1.76338048 |
| 117 | Malignant gastrointestinal tract tumors (HP:0006749) | 1.75427456 |
| 118 | Gastrointestinal carcinoma (HP:0002672) | 1.75427456 |
| 119 | Hepatocellular necrosis (HP:0001404) | 1.74449003 |
| 120 | Missing ribs (HP:0000921) | 1.73434114 |
| 121 | Combined immunodeficiency (HP:0005387) | 1.73310115 |
| 122 | Intestinal atresia (HP:0011100) | 1.73112803 |
| 123 | Multiple enchondromatosis (HP:0005701) | 1.72830957 |
| 124 | Abnormality of the fetal cardiovascular system (HP:0010948) | 1.71157223 |
| 125 | Abnormal umbilical cord blood vessels (HP:0011403) | 1.71157223 |
| 126 | Single umbilical artery (HP:0001195) | 1.71157223 |
| 127 | Ovarian neoplasm (HP:0100615) | 1.70620989 |
| 128 | Abnormality of the pons (HP:0007361) | 1.70000093 |
| 129 | Oligodactyly (hands) (HP:0001180) | 1.68628081 |
| 130 | Absent septum pellucidum (HP:0001331) | 1.68203589 |
| 131 | Increased serum lactate (HP:0002151) | 1.67350190 |
| 132 | Neoplasm of the colon (HP:0100273) | 1.67187020 |
| 133 | Microtia (HP:0008551) | 1.66312373 |
| 134 | Hypoplasia of the pons (HP:0012110) | 1.66134019 |
| 135 | Small hand (HP:0200055) | 1.65712408 |
| 136 | Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161) | 1.63031237 |
| 137 | Abnormality of serum amino acid levels (HP:0003112) | 1.55042767 |
| 138 | Hemivertebrae (HP:0002937) | 1.54213762 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | CDC7 | 4.60457283 |
| 2 | BUB1 | 3.81701106 |
| 3 | WEE1 | 3.53639738 |
| 4 | NEK2 | 3.48380481 |
| 5 | TTK | 3.34582919 |
| 6 | CDK12 | 2.80689158 |
| 7 | PLK4 | 2.73973712 |
| 8 | SRPK1 | 2.61565506 |
| 9 | LATS1 | 2.58547447 |
| 10 | PLK1 | 2.32084003 |
| 11 | BRSK2 | 2.25073668 |
| 12 | EIF2AK1 | 2.25013611 |
| 13 | STK38L | 2.22505264 |
| 14 | VRK2 | 2.21757007 |
| 15 | TRIM28 | 2.16575948 |
| 16 | CHEK2 | 2.03590580 |
| 17 | AURKB | 1.96488197 |
| 18 | LATS2 | 1.92239773 |
| 19 | PLK3 | 1.90443791 |
| 20 | MST4 | 1.90202226 |
| 21 | ACVR1B | 1.83042796 |
| 22 | MKNK1 | 1.75744486 |
| 23 | TAF1 | 1.74149954 |
| 24 | EEF2K | 1.73626400 |
| 25 | CDK7 | 1.69847600 |
| 26 | STK3 | 1.69454166 |
| 27 | EPHA2 | 1.68699350 |
| 28 | MKNK2 | 1.68651860 |
| 29 | * ATR | 1.58772577 |
| 30 | NEK1 | 1.56732833 |
| 31 | RPS6KB2 | 1.56604385 |
| 32 | ZAK | 1.53896495 |
| 33 | CHEK1 | 1.48456163 |
| 34 | CDK4 | 1.45870141 |
| 35 | MAP3K8 | 1.43439552 |
| 36 | VRK1 | 1.40774647 |
| 37 | DYRK3 | 1.39916382 |
| 38 | RPS6KA4 | 1.39616900 |
| 39 | STK10 | 1.35724704 |
| 40 | BRSK1 | 1.31584826 |
| 41 | STK4 | 1.31549366 |
| 42 | BRD4 | 1.25604820 |
| 43 | TSSK6 | 1.23053409 |
| 44 | TLK1 | 1.22822452 |
| 45 | PASK | 1.22435077 |
| 46 | AURKA | 1.21872095 |
| 47 | MELK | 1.20493022 |
| 48 | WNK3 | 1.17407186 |
| 49 | * ATM | 1.15767046 |
| 50 | EIF2AK3 | 1.12041095 |
| 51 | PIM1 | 1.00302378 |
| 52 | ERBB3 | 1.00157910 |
| 53 | TNIK | 0.98965190 |
| 54 | CDK2 | 0.97050644 |
| 55 | CDK8 | 0.96661053 |
| 56 | BMPR1B | 0.91518030 |
| 57 | CDK6 | 0.91202736 |
| 58 | NME2 | 0.90944964 |
| 59 | BRAF | 0.86930118 |
| 60 | MAP3K6 | 0.86072713 |
| 61 | CDK9 | 0.84451286 |
| 62 | STK16 | 0.84158563 |
| 63 | EIF2AK2 | 0.83793084 |
| 64 | ERBB4 | 0.81484411 |
| 65 | BCR | 0.80341674 |
| 66 | TESK2 | 0.79575133 |
| 67 | CLK1 | 0.78867552 |
| 68 | CDK1 | 0.77723294 |
| 69 | PKN2 | 0.70529006 |
| 70 | PAK4 | 0.68136333 |
| 71 | PDK2 | 0.67567196 |
| 72 | DYRK2 | 0.65459415 |
| 73 | ALK | 0.64971821 |
| 74 | NME1 | 0.62587074 |
| 75 | FLT3 | 0.60148147 |
| 76 | CSNK1G1 | 0.59044821 |
| 77 | CCNB1 | 0.57630736 |
| 78 | PLK2 | 0.57259085 |
| 79 | SCYL2 | 0.56081894 |
| 80 | MAP3K10 | 0.53787977 |
| 81 | TGFBR1 | 0.52852706 |
| 82 | PAK1 | 0.49960786 |
| 83 | MTOR | 0.49721816 |
| 84 | RAF1 | 0.49376122 |
| 85 | MARK3 | 0.49359215 |
| 86 | PRKCI | 0.47678265 |
| 87 | RPS6KA5 | 0.45137212 |
| 88 | CSNK2A1 | 0.44994150 |
| 89 | CSNK2A2 | 0.43826181 |
| 90 | NUAK1 | 0.41733705 |
| 91 | STK39 | 0.41287830 |
| 92 | JAK3 | 0.40861010 |
| 93 | MAPKAPK3 | 0.40711718 |
| 94 | CSNK1G3 | 0.39684415 |
| 95 | CSNK1D | 0.38334472 |
| 96 | MAPK14 | 0.37892894 |
| 97 | PRKDC | 0.36246318 |
| 98 | PBK | 0.35279198 |
| 99 | CDK3 | 0.34640651 |
| 100 | AKT2 | 0.34533788 |
| 101 | NLK | 0.34074785 |
| 102 | CSNK1G2 | 0.33324262 |
| 103 | SIK3 | 0.32910229 |
| 104 | FGFR1 | 0.32604357 |
| 105 | CHUK | 0.32368400 |
| 106 | AKT1 | 0.31587043 |
| 107 | AKT3 | 0.30368003 |
| 108 | CSNK1E | 0.30280241 |
| 109 | CDK18 | 0.28299211 |
| 110 | MAPK1 | 0.27552822 |
| 111 | CSNK1A1L | 0.26668917 |
| 112 | MAP3K5 | 0.26007060 |
| 113 | GSK3B | 0.25214969 |
| 114 | MOS | 0.25124598 |
| 115 | TRPM7 | 0.24506904 |
| 116 | TAOK1 | 0.24457153 |
| 117 | KSR1 | 0.23822103 |
| 118 | YES1 | 0.23523230 |
| 119 | CDK15 | 0.22866863 |
| 120 | NEK9 | 0.22324493 |
| 121 | CDK14 | 0.21488573 |
| 122 | CDK11A | 0.20399324 |
| 123 | WNK4 | 0.19126204 |
| 124 | PNCK | 0.18160746 |
| 125 | KSR2 | 0.17720214 |
| 126 | FRK | 0.17510002 |
| 127 | MAPK10 | 0.14041927 |
| 128 | MAPK11 | 0.13986079 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA replication_Homo sapiens_hsa03030 | 4.20680506 |
| 2 | Mismatch repair_Homo sapiens_hsa03430 | 3.84829064 |
| 3 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.56482802 |
| 4 | * Cell cycle_Homo sapiens_hsa04110 | 3.46839313 |
| 5 | RNA transport_Homo sapiens_hsa03013 | 3.22747157 |
| 6 | Homologous recombination_Homo sapiens_hsa03440 | 3.19070498 |
| 7 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 2.93867102 |
| 8 | RNA polymerase_Homo sapiens_hsa03020 | 2.88233222 |
| 9 | Spliceosome_Homo sapiens_hsa03040 | 2.87907161 |
| 10 | Base excision repair_Homo sapiens_hsa03410 | 2.76675601 |
| 11 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.71874620 |
| 12 | Protein export_Homo sapiens_hsa03060 | 2.64500615 |
| 13 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.46849365 |
| 14 | Basal transcription factors_Homo sapiens_hsa03022 | 2.46726703 |
| 15 | RNA degradation_Homo sapiens_hsa03018 | 2.33435306 |
| 16 | Non-homologous end-joining_Homo sapiens_hsa03450 | 2.31123819 |
| 17 | p53 signaling pathway_Homo sapiens_hsa04115 | 2.17282764 |
| 18 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 2.10523789 |
| 19 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.01585725 |
| 20 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.97555459 |
| 21 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.92683248 |
| 22 | Ribosome_Homo sapiens_hsa03010 | 1.53378129 |
| 23 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 1.47872302 |
| 24 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 1.47402088 |
| 25 | Proteasome_Homo sapiens_hsa03050 | 1.39593802 |
| 26 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 1.37410197 |
| 27 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.36243685 |
| 28 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.33497236 |
| 29 | Oocyte meiosis_Homo sapiens_hsa04114 | 1.32945733 |
| 30 | Parkinsons disease_Homo sapiens_hsa05012 | 1.31767539 |
| 31 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.28247177 |
| 32 | Viral carcinogenesis_Homo sapiens_hsa05203 | 1.24859651 |
| 33 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.24335855 |
| 34 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 1.21920931 |
| 35 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 1.20006345 |
| 36 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.18967795 |
| 37 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.18454783 |
| 38 | Huntingtons disease_Homo sapiens_hsa05016 | 1.13921877 |
| 39 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.08213772 |
| 40 | Purine metabolism_Homo sapiens_hsa00230 | 1.08096042 |
| 41 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.05905508 |
| 42 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.98491526 |
| 43 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.98379234 |
| 44 | HTLV-I infection_Homo sapiens_hsa05166 | 0.95283190 |
| 45 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.94596046 |
| 46 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.92350870 |
| 47 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.91778485 |
| 48 | Thyroid cancer_Homo sapiens_hsa05216 | 0.84881488 |
| 49 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.84692275 |
| 50 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.83078543 |
| 51 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.79492504 |
| 52 | Colorectal cancer_Homo sapiens_hsa05210 | 0.76956147 |
| 53 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.75983131 |
| 54 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.73978036 |
| 55 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.72199213 |
| 56 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.71490822 |
| 57 | Adherens junction_Homo sapiens_hsa04520 | 0.70875539 |
| 58 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.66386945 |
| 59 | Carbon metabolism_Homo sapiens_hsa01200 | 0.64491767 |
| 60 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.64052228 |
| 61 | Alzheimers disease_Homo sapiens_hsa05010 | 0.63587792 |
| 62 | Hepatitis B_Homo sapiens_hsa05161 | 0.63532944 |
| 63 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.63471612 |
| 64 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.62516715 |
| 65 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.61126470 |
| 66 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.60094027 |
| 67 | Apoptosis_Homo sapiens_hsa04210 | 0.59680774 |
| 68 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.58774067 |
| 69 | Prostate cancer_Homo sapiens_hsa05215 | 0.58417456 |
| 70 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.57714458 |
| 71 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.57114041 |
| 72 | Alcoholism_Homo sapiens_hsa05034 | 0.56147079 |
| 73 | Measles_Homo sapiens_hsa05162 | 0.54688104 |
| 74 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.54151071 |
| 75 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.52126005 |
| 76 | Influenza A_Homo sapiens_hsa05164 | 0.50813275 |
| 77 | Bladder cancer_Homo sapiens_hsa05219 | 0.48721089 |
| 78 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.48528804 |
| 79 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.47861514 |
| 80 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.47755646 |
| 81 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.47419979 |
| 82 | Pathways in cancer_Homo sapiens_hsa05200 | 0.46782798 |
| 83 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.46419503 |
| 84 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.45424624 |
| 85 | Endometrial cancer_Homo sapiens_hsa05213 | 0.43353459 |
| 86 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.43342880 |
| 87 | Shigellosis_Homo sapiens_hsa05131 | 0.43096093 |
| 88 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.42170582 |
| 89 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.41698983 |
| 90 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.40768185 |
| 91 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.39771750 |
| 92 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.39759671 |
| 93 | Melanoma_Homo sapiens_hsa05218 | 0.39166189 |
| 94 | Metabolic pathways_Homo sapiens_hsa01100 | 0.38574125 |
| 95 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.37252579 |
| 96 | Legionellosis_Homo sapiens_hsa05134 | 0.36642013 |
| 97 | Lysine degradation_Homo sapiens_hsa00310 | 0.34321367 |
| 98 | Viral myocarditis_Homo sapiens_hsa05416 | 0.33713662 |
| 99 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.33096049 |
| 100 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.31865784 |
| 101 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.31616538 |
| 102 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.30144842 |
| 103 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.29098250 |
| 104 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.28095001 |
| 105 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.27649716 |
| 106 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.27610186 |
| 107 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.27313718 |
| 108 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.26942556 |
| 109 | Tight junction_Homo sapiens_hsa04530 | 0.26017179 |
| 110 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.25613894 |
| 111 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.24545414 |
| 112 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.24137565 |
| 113 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.23598002 |
| 114 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.22066875 |
| 115 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.21671997 |
| 116 | TNF signaling pathway_Homo sapiens_hsa04668 | 0.21547501 |
| 117 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.21445609 |
| 118 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.21227463 |
| 119 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.20935007 |
| 120 | PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | 0.20088913 |
| 121 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.20074654 |
| 122 | Circadian rhythm_Homo sapiens_hsa04710 | 0.19347669 |
| 123 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.19286476 |
| 124 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.18695106 |
| 125 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.18215536 |
| 126 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.17024359 |
| 127 | Toxoplasmosis_Homo sapiens_hsa05145 | 0.16770778 |
| 128 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.16197709 |
| 129 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.15675020 |
| 130 | Phototransduction_Homo sapiens_hsa04744 | 0.13723733 |
| 131 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.13203168 |
| 132 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.10164471 |
| 133 | Peroxisome_Homo sapiens_hsa04146 | 0.07436828 |
| 134 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.06984480 |
| 135 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.05519593 |
| 136 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.05131026 |
| 137 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.04963405 |

