

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA double-strand break processing (GO:0000729) | 5.62012968 |
| 2 | CENP-A containing nucleosome assembly (GO:0034080) | 5.52018722 |
| 3 | chromatin remodeling at centromere (GO:0031055) | 5.48828580 |
| 4 | proteasome assembly (GO:0043248) | 5.33590807 |
| 5 | protein localization to kinetochore (GO:0034501) | 5.03174253 |
| 6 | histone exchange (GO:0043486) | 4.82449398 |
| 7 | lens fiber cell differentiation (GO:0070306) | 4.40986756 |
| 8 | DNA replication checkpoint (GO:0000076) | 4.33178454 |
| 9 | peptidyl-histidine modification (GO:0018202) | 4.23388517 |
| 10 | DNA replication-independent nucleosome organization (GO:0034724) | 4.20590997 |
| 11 | DNA replication-independent nucleosome assembly (GO:0006336) | 4.20590997 |
| 12 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 4.20582177 |
| 13 | kinetochore organization (GO:0051383) | 4.20286945 |
| 14 | DNA ligation (GO:0006266) | 4.14889267 |
| 15 | mitotic metaphase plate congression (GO:0007080) | 4.14116708 |
| 16 | negative regulation of DNA-dependent DNA replication (GO:2000104) | 4.06039360 |
| 17 | dopaminergic neuron differentiation (GO:0071542) | 4.04945118 |
| 18 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 4.02922667 |
| 19 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 4.01941369 |
| 20 | protein localization to chromosome, centromeric region (GO:0071459) | 4.01124225 |
| 21 | replication fork processing (GO:0031297) | 3.96882581 |
| 22 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.90816611 |
| 23 | kinetochore assembly (GO:0051382) | 3.88264722 |
| 24 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.79709382 |
| 25 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.77043125 |
| 26 | regulation of nuclear cell cycle DNA replication (GO:0033262) | 3.74959393 |
| 27 | DNA catabolic process, exonucleolytic (GO:0000738) | 3.64361853 |
| 28 | termination of RNA polymerase I transcription (GO:0006363) | 3.63976837 |
| 29 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 3.63461514 |
| 30 | regulation of mitotic spindle checkpoint (GO:1903504) | 3.63461514 |
| 31 | lens morphogenesis in camera-type eye (GO:0002089) | 3.59398296 |
| 32 | transcription elongation from RNA polymerase I promoter (GO:0006362) | 3.58346053 |
| 33 | negative regulation of transcription regulatory region DNA binding (GO:2000678) | 3.57862106 |
| 34 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.56906233 |
| 35 | negative regulation of ligase activity (GO:0051352) | 3.56306494 |
| 36 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.56306494 |
| 37 | negative regulation of fibroblast apoptotic process (GO:2000270) | 3.54273866 |
| 38 | ribosome assembly (GO:0042255) | 3.53465540 |
| 39 | metaphase plate congression (GO:0051310) | 3.47492275 |
| 40 | signal peptide processing (GO:0006465) | 3.46343260 |
| 41 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.40448955 |
| 42 | ATP synthesis coupled proton transport (GO:0015986) | 3.40448955 |
| 43 | maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005) | 3.40248780 |
| 44 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.40164405 |
| 45 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.40164405 |
| 46 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.40164405 |
| 47 | protein complex biogenesis (GO:0070271) | 3.40150565 |
| 48 | mitotic G2/M transition checkpoint (GO:0044818) | 3.39582986 |
| 49 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.38838650 |
| 50 | IMP biosynthetic process (GO:0006188) | 3.38443395 |
| 51 | transcription initiation from RNA polymerase I promoter (GO:0006361) | 3.37536063 |
| 52 | establishment of integrated proviral latency (GO:0075713) | 3.37473825 |
| 53 | spindle checkpoint (GO:0031577) | 3.35884307 |
| 54 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.35275195 |
| 55 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.35275195 |
| 56 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.33102631 |
| 57 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.33102631 |
| 58 | NADH dehydrogenase complex assembly (GO:0010257) | 3.33102631 |
| 59 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.31561371 |
| 60 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.27877830 |
| 61 | regulation of centriole replication (GO:0046599) | 3.26251169 |
| 62 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.25719948 |
| 63 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.25719948 |
| 64 | pseudouridine synthesis (GO:0001522) | 3.25165678 |
| 65 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.24852243 |
| 66 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.24349126 |
| 67 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.23164948 |
| 68 | purine nucleobase biosynthetic process (GO:0009113) | 3.22284071 |
| 69 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.17541524 |
| 70 | regulation of attachment of spindle microtubules to kinetochore (GO:0051988) | 3.15231784 |
| 71 | positive regulation of ligase activity (GO:0051351) | 3.14691102 |
| 72 | DNA strand elongation involved in DNA replication (GO:0006271) | 3.13793913 |
| 73 | nucleobase biosynthetic process (GO:0046112) | 3.13387253 |
| 74 | mitotic spindle checkpoint (GO:0071174) | 3.12996336 |
| 75 | DNA strand renaturation (GO:0000733) | 3.12974906 |
| 76 | RNA-dependent DNA replication (GO:0006278) | 3.12889470 |
| 77 | transcription from RNA polymerase I promoter (GO:0006360) | 3.09215473 |
| 78 | termination of RNA polymerase II transcription (GO:0006369) | 3.09102171 |
| 79 | negative regulation of mitotic sister chromatid separation (GO:2000816) | 3.06761779 |
| 80 | negative regulation of sister chromatid segregation (GO:0033046) | 3.06761779 |
| 81 | negative regulation of mitotic metaphase/anaphase transition (GO:0045841) | 3.06761779 |
| 82 | negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100) | 3.06761779 |
| 83 | negative regulation of mitotic sister chromatid segregation (GO:0033048) | 3.06761779 |
| 84 | mitotic sister chromatid segregation (GO:0000070) | 3.06065527 |
| 85 | sister chromatid segregation (GO:0000819) | 3.05197936 |
| 86 | telomere maintenance via telomerase (GO:0007004) | 3.03065680 |
| 87 | regulation of DNA methylation (GO:0044030) | 3.02947804 |
| 88 | DNA replication-dependent nucleosome organization (GO:0034723) | 3.02606025 |
| 89 | DNA replication-dependent nucleosome assembly (GO:0006335) | 3.02606025 |
| 90 | DNA-templated transcription, termination (GO:0006353) | 3.01686513 |
| 91 | centriole replication (GO:0007099) | 3.01623355 |
| 92 | chaperone-mediated protein transport (GO:0072321) | 3.01582161 |
| 93 | DNA strand elongation (GO:0022616) | 3.01514898 |
| 94 | respiratory electron transport chain (GO:0022904) | 3.00311233 |
| 95 | negative regulation of chromosome segregation (GO:0051985) | 2.99565035 |
| 96 | resolution of meiotic recombination intermediates (GO:0000712) | 2.98885117 |
| 97 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 2.98656179 |
| 98 | respiratory chain complex IV assembly (GO:0008535) | 2.97863445 |
| 99 | midbrain development (GO:0030901) | 2.94464104 |
| 100 | G1/S transition of mitotic cell cycle (GO:0000082) | 2.93295747 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 5.62764925 |
| 2 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.67314475 |
| 3 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.92259131 |
| 4 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.91909633 |
| 5 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.88298756 |
| 6 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 3.79638299 |
| 7 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 3.12413626 |
| 8 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 3.10969953 |
| 9 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.93608460 |
| 10 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.72490626 |
| 11 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.71240248 |
| 12 | AR_21909140_ChIP-Seq_LNCAP_Human | 2.68613897 |
| 13 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.66457180 |
| 14 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.63167400 |
| 15 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.54074738 |
| 16 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.45200074 |
| 17 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.36457374 |
| 18 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.10306607 |
| 19 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 2.08977808 |
| 20 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 2.03894705 |
| 21 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.02306216 |
| 22 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.02278422 |
| 23 | VDR_22108803_ChIP-Seq_LS180_Human | 2.02188636 |
| 24 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.97744331 |
| 25 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.95776499 |
| 26 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.92142558 |
| 27 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.90998041 |
| 28 | EWS_26573619_Chip-Seq_HEK293_Human | 1.84130232 |
| 29 | FUS_26573619_Chip-Seq_HEK293_Human | 1.82593210 |
| 30 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.82125872 |
| 31 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.75008612 |
| 32 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.74186627 |
| 33 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.72076716 |
| 34 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.71056774 |
| 35 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.69624426 |
| 36 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.69506902 |
| 37 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.66109588 |
| 38 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.63029548 |
| 39 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.62996963 |
| 40 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.61257137 |
| 41 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.58321679 |
| 42 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.55455791 |
| 43 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.54793971 |
| 44 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.51667518 |
| 45 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.50047781 |
| 46 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.49464795 |
| 47 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.47964797 |
| 48 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.47282703 |
| 49 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.44147264 |
| 50 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.43429641 |
| 51 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.42220136 |
| 52 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.40508526 |
| 53 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.40274092 |
| 54 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.37203741 |
| 55 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.34914213 |
| 56 | P300_19829295_ChIP-Seq_ESCs_Human | 1.34819203 |
| 57 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.33605526 |
| 58 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.32340205 |
| 59 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 1.30080616 |
| 60 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.26332540 |
| 61 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.25910426 |
| 62 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.25384358 |
| 63 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.23005013 |
| 64 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.22937435 |
| 65 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 1.22614252 |
| 66 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.19270725 |
| 67 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.17129329 |
| 68 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.16941202 |
| 69 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.12596807 |
| 70 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.11724747 |
| 71 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 1.11050043 |
| 72 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.10214138 |
| 73 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.08523096 |
| 74 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.07408415 |
| 75 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.06733592 |
| 76 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.05053306 |
| 77 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.04021240 |
| 78 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.02516419 |
| 79 | HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse | 1.02104406 |
| 80 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 0.99190084 |
| 81 | ER_23166858_ChIP-Seq_MCF-7_Human | 0.96224879 |
| 82 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 0.95187166 |
| 83 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.93896227 |
| 84 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 0.93163932 |
| 85 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 0.93025640 |
| 86 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 0.89055082 |
| 87 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 0.86329741 |
| 88 | TP53_22573176_ChIP-Seq_HFKS_Human | 0.86101708 |
| 89 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.85454400 |
| 90 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.82821539 |
| 91 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 0.82821539 |
| 92 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 0.82386366 |
| 93 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 0.81654215 |
| 94 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.81075833 |
| 95 | SUZ12_18555785_Chip-Seq_ESCs_Mouse | 0.80074063 |
| 96 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 0.79853212 |
| 97 | LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.78179438 |
| 98 | BCAT_22108803_ChIP-Seq_LS180_Human | 0.78018399 |
| 99 | SOX2_19829295_ChIP-Seq_ESCs_Human | 0.77835321 |
| 100 | NANOG_19829295_ChIP-Seq_ESCs_Human | 0.77835321 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0001346_abnormal_lacrimal_gland | 5.05551682 |
| 2 | MP0000569_abnormal_digit_pigmentation | 3.67243762 |
| 3 | MP0010094_abnormal_chromosome_stability | 3.59362637 |
| 4 | MP0000566_synostosis | 3.58680984 |
| 5 | MP0009697_abnormal_copulation | 3.33912245 |
| 6 | MP0008057_abnormal_DNA_replication | 3.29499119 |
| 7 | MP0004957_abnormal_blastocyst_morpholog | 3.18496799 |
| 8 | MP0003693_abnormal_embryo_hatching | 3.07774668 |
| 9 | MP0003111_abnormal_nucleus_morphology | 2.82804218 |
| 10 | MP0008058_abnormal_DNA_repair | 2.68963065 |
| 11 | MP0003077_abnormal_cell_cycle | 2.66470073 |
| 12 | MP0006292_abnormal_olfactory_placode | 2.52781814 |
| 13 | MP0002735_abnormal_chemical_nociception | 2.45510918 |
| 14 | MP0000372_irregular_coat_pigmentation | 2.34473385 |
| 15 | MP0003890_abnormal_embryonic-extraembry | 2.29956681 |
| 16 | MP0001905_abnormal_dopamine_level | 2.26994814 |
| 17 | MP0001529_abnormal_vocalization | 2.26596964 |
| 18 | MP0002102_abnormal_ear_morphology | 2.22142378 |
| 19 | MP0003937_abnormal_limbs/digits/tail_de | 2.07270632 |
| 20 | MP0002938_white_spotting | 1.97290176 |
| 21 | MP0008932_abnormal_embryonic_tissue | 1.94741544 |
| 22 | MP0003786_premature_aging | 1.73496347 |
| 23 | MP0003718_maternal_effect | 1.66409316 |
| 24 | MP0006035_abnormal_mitochondrial_morpho | 1.64611500 |
| 25 | MP0008789_abnormal_olfactory_epithelium | 1.63915532 |
| 26 | MP0001188_hyperpigmentation | 1.61083956 |
| 27 | MP0008007_abnormal_cellular_replicative | 1.57602271 |
| 28 | MP0004215_abnormal_myocardial_fiber | 1.55696452 |
| 29 | MP0001299_abnormal_eye_distance/ | 1.53515302 |
| 30 | MP0006072_abnormal_retinal_apoptosis | 1.49177577 |
| 31 | MP0002638_abnormal_pupillary_reflex | 1.48606787 |
| 32 | MP0001293_anophthalmia | 1.44214081 |
| 33 | MP0003123_paternal_imprinting | 1.39925220 |
| 34 | MP0002736_abnormal_nociception_after | 1.38674503 |
| 35 | MP0003938_abnormal_ear_development | 1.37355876 |
| 36 | MP0003283_abnormal_digestive_organ | 1.36621161 |
| 37 | MP0003567_abnormal_fetal_cardiomyocyte | 1.31085880 |
| 38 | MP0001286_abnormal_eye_development | 1.29538840 |
| 39 | MP0000049_abnormal_middle_ear | 1.29179955 |
| 40 | MP0002234_abnormal_pharynx_morphology | 1.28723945 |
| 41 | MP0003136_yellow_coat_color | 1.26942698 |
| 42 | MP0001968_abnormal_touch/_nociception | 1.24295588 |
| 43 | MP0003119_abnormal_digestive_system | 1.19380325 |
| 44 | MP0005394_taste/olfaction_phenotype | 1.17739028 |
| 45 | MP0005499_abnormal_olfactory_system | 1.17739028 |
| 46 | MP0002751_abnormal_autonomic_nervous | 1.15654699 |
| 47 | MP0001177_atelectasis | 1.13695543 |
| 48 | MP0003959_abnormal_lean_body | 1.13219355 |
| 49 | MP0006054_spinal_hemorrhage | 1.12688338 |
| 50 | MP0002734_abnormal_mechanical_nocicepti | 1.10593490 |
| 51 | MP0000350_abnormal_cell_proliferation | 1.09519130 |
| 52 | MP0003941_abnormal_skin_development | 1.07878794 |
| 53 | MP0004147_increased_porphyrin_level | 1.07755675 |
| 54 | MP0008877_abnormal_DNA_methylation | 1.06230863 |
| 55 | MP0002697_abnormal_eye_size | 1.03745522 |
| 56 | MP0002111_abnormal_tail_morphology | 1.03545733 |
| 57 | MP0005670_abnormal_white_adipose | 1.01108242 |
| 58 | MP0008872_abnormal_physiological_respon | 1.00286553 |
| 59 | MP0009672_abnormal_birth_weight | 1.00045830 |
| 60 | MP0006036_abnormal_mitochondrial_physio | 0.98820867 |
| 61 | MP0001697_abnormal_embryo_size | 0.95267645 |
| 62 | MP0005084_abnormal_gallbladder_morpholo | 0.94375972 |
| 63 | MP0001672_abnormal_embryogenesis/_devel | 0.93772092 |
| 64 | MP0005380_embryogenesis_phenotype | 0.93772092 |
| 65 | MP0002733_abnormal_thermal_nociception | 0.92958204 |
| 66 | MP0002233_abnormal_nose_morphology | 0.92313079 |
| 67 | MP0002282_abnormal_trachea_morphology | 0.91316255 |
| 68 | MP0001485_abnormal_pinna_reflex | 0.90227572 |
| 69 | MP0001730_embryonic_growth_arrest | 0.88129801 |
| 70 | MP0002132_abnormal_respiratory_system | 0.87089247 |
| 71 | MP0001984_abnormal_olfaction | 0.86092901 |
| 72 | MP0001929_abnormal_gametogenesis | 0.84683230 |
| 73 | MP0005391_vision/eye_phenotype | 0.83217458 |
| 74 | MP0003121_genomic_imprinting | 0.82646288 |
| 75 | MP0005551_abnormal_eye_electrophysiolog | 0.81814559 |
| 76 | MP0002085_abnormal_embryonic_tissue | 0.78972337 |
| 77 | MP0002210_abnormal_sex_determination | 0.77976896 |
| 78 | MP0002084_abnormal_developmental_patter | 0.75599032 |
| 79 | MP0002653_abnormal_ependyma_morphology | 0.75528032 |
| 80 | MP0002092_abnormal_eye_morphology | 0.74647219 |
| 81 | MP0003137_abnormal_impulse_conducting | 0.74209584 |
| 82 | MP0001324_abnormal_eye_pigmentation | 0.73270106 |
| 83 | MP0001486_abnormal_startle_reflex | 0.71839498 |
| 84 | MP0005365_abnormal_bile_salt | 0.71100834 |
| 85 | MP0009053_abnormal_anal_canal | 0.70707672 |
| 86 | MP0002088_abnormal_embryonic_growth/wei | 0.70003319 |
| 87 | MP0003984_embryonic_growth_retardation | 0.69689042 |
| 88 | MP0005253_abnormal_eye_physiology | 0.69317360 |
| 89 | MP0002080_prenatal_lethality | 0.67874764 |
| 90 | MP0003698_abnormal_male_reproductive | 0.65853911 |
| 91 | MP0003943_abnormal_hepatobiliary_system | 0.65427698 |
| 92 | MP0005197_abnormal_uvea_morphology | 0.64992941 |
| 93 | MP0002277_abnormal_respiratory_mucosa | 0.64516414 |
| 94 | MP0001119_abnormal_female_reproductive | 0.64393840 |
| 95 | MP0000313_abnormal_cell_death | 0.63563342 |
| 96 | MP0004197_abnormal_fetal_growth/weight/ | 0.63481103 |
| 97 | MP0008995_early_reproductive_senescence | 0.63214542 |
| 98 | MP0009250_abnormal_appendicular_skeleto | 0.62465352 |
| 99 | MP0005195_abnormal_posterior_eye | 0.61841461 |
| 100 | MP0003755_abnormal_palate_morphology | 0.61200613 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Progressive macrocephaly (HP:0004481) | 4.59970720 |
| 2 | Acute necrotizing encephalopathy (HP:0006965) | 4.54609543 |
| 3 | Abnormal mitochondria in muscle tissue (HP:0008316) | 4.36872041 |
| 4 | Hepatocellular necrosis (HP:0001404) | 3.95933304 |
| 5 | Acute encephalopathy (HP:0006846) | 3.82574265 |
| 6 | Mitochondrial inheritance (HP:0001427) | 3.74720479 |
| 7 | Increased CSF lactate (HP:0002490) | 3.42957036 |
| 8 | Birth length less than 3rd percentile (HP:0003561) | 3.42004392 |
| 9 | Increased hepatocellular lipid droplets (HP:0006565) | 3.37892380 |
| 10 | Anterior segment dysgenesis (HP:0007700) | 3.36150312 |
| 11 | Hepatic necrosis (HP:0002605) | 3.30681822 |
| 12 | Meckel diverticulum (HP:0002245) | 3.23094344 |
| 13 | Cerebral edema (HP:0002181) | 3.10775417 |
| 14 | Abnormality of the ileum (HP:0001549) | 3.08791106 |
| 15 | Lipid accumulation in hepatocytes (HP:0006561) | 3.07171999 |
| 16 | Small intestinal stenosis (HP:0012848) | 3.05044585 |
| 17 | Duodenal stenosis (HP:0100867) | 3.05044585 |
| 18 | Volvulus (HP:0002580) | 2.95218295 |
| 19 | Congenital, generalized hypertrichosis (HP:0004540) | 2.94735312 |
| 20 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.92371334 |
| 21 | Embryonal renal neoplasm (HP:0011794) | 2.90977589 |
| 22 | Abnormality of chromosome stability (HP:0003220) | 2.83650149 |
| 23 | Stomach cancer (HP:0012126) | 2.73654081 |
| 24 | Abnormality of the duodenum (HP:0002246) | 2.73334584 |
| 25 | Short middle phalanx of the 5th finger (HP:0004220) | 2.70621190 |
| 26 | Biliary tract neoplasm (HP:0100574) | 2.68599937 |
| 27 | Abnormality of the labia minora (HP:0012880) | 2.65482133 |
| 28 | Abnormality of the septum pellucidum (HP:0007375) | 2.61741221 |
| 29 | Nephroblastoma (Wilms tumor) (HP:0002667) | 2.61574562 |
| 30 | Abnormality of the preputium (HP:0100587) | 2.58647065 |
| 31 | Abnormal lung lobation (HP:0002101) | 2.53944531 |
| 32 | Nephronophthisis (HP:0000090) | 2.49214758 |
| 33 | Hyperinsulinemic hypoglycemia (HP:0000825) | 2.48481576 |
| 34 | Increased serum lactate (HP:0002151) | 2.47380382 |
| 35 | Increased intramyocellular lipid droplets (HP:0012240) | 2.46357715 |
| 36 | Cortical dysplasia (HP:0002539) | 2.44899836 |
| 37 | Pancreatic islet-cell hyperplasia (HP:0004510) | 2.40535158 |
| 38 | Neoplasm of the colon (HP:0100273) | 2.39645850 |
| 39 | Respiratory difficulties (HP:0002880) | 2.33456570 |
| 40 | Optic disc pallor (HP:0000543) | 2.30729061 |
| 41 | Triphalangeal thumb (HP:0001199) | 2.29456937 |
| 42 | Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161) | 2.26937381 |
| 43 | Leukodystrophy (HP:0002415) | 2.24502049 |
| 44 | Pancreatic cysts (HP:0001737) | 2.21723910 |
| 45 | Hypoglycemic seizures (HP:0002173) | 2.17827203 |
| 46 | Respiratory failure (HP:0002878) | 2.17069864 |
| 47 | Renal Fanconi syndrome (HP:0001994) | 2.16736930 |
| 48 | Acanthocytosis (HP:0001927) | 2.15859343 |
| 49 | Chromsome breakage (HP:0040012) | 2.12737660 |
| 50 | Septo-optic dysplasia (HP:0100842) | 2.12539941 |
| 51 | Conjunctival hamartoma (HP:0100780) | 2.11567311 |
| 52 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.07245511 |
| 53 | Supernumerary spleens (HP:0009799) | 2.06317854 |
| 54 | Neoplasm of the small intestine (HP:0100833) | 2.05791368 |
| 55 | Lactic acidosis (HP:0003128) | 2.05045062 |
| 56 | Arteriovenous malformation (HP:0100026) | 2.02581676 |
| 57 | Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376) | 2.02462691 |
| 58 | Neoplasm of the rectum (HP:0100743) | 2.02302510 |
| 59 | Abnormality of the middle phalanx of the 5th finger (HP:0004219) | 2.01286644 |
| 60 | Horseshoe kidney (HP:0000085) | 2.00884474 |
| 61 | Absent radius (HP:0003974) | 1.98583647 |
| 62 | Exercise intolerance (HP:0003546) | 1.97610037 |
| 63 | Megalencephaly (HP:0001355) | 1.96556777 |
| 64 | Sloping forehead (HP:0000340) | 1.94160643 |
| 65 | Delayed CNS myelination (HP:0002188) | 1.92936113 |
| 66 | Clubbing of toes (HP:0100760) | 1.92115686 |
| 67 | Colon cancer (HP:0003003) | 1.91600073 |
| 68 | Increased muscle lipid content (HP:0009058) | 1.91254066 |
| 69 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 1.90601015 |
| 70 | Absent forearm bone (HP:0003953) | 1.88450190 |
| 71 | Aplasia involving forearm bones (HP:0009822) | 1.88450190 |
| 72 | Ovarian neoplasm (HP:0100615) | 1.88237613 |
| 73 | CNS demyelination (HP:0007305) | 1.87744350 |
| 74 | Myelodysplasia (HP:0002863) | 1.87049157 |
| 75 | Macrocytic anemia (HP:0001972) | 1.82747335 |
| 76 | Abnormality of the phalanges of the 5th finger (HP:0004213) | 1.82140535 |
| 77 | Hypoglycemic coma (HP:0001325) | 1.79827410 |
| 78 | X-linked dominant inheritance (HP:0001423) | 1.78250468 |
| 79 | Abnormality of the renal medulla (HP:0100957) | 1.77952366 |
| 80 | Abnormality of midbrain morphology (HP:0002418) | 1.75778523 |
| 81 | Molar tooth sign on MRI (HP:0002419) | 1.75778523 |
| 82 | Tubular atrophy (HP:0000092) | 1.75458069 |
| 83 | Carpal bone hypoplasia (HP:0001498) | 1.74778540 |
| 84 | Emotional lability (HP:0000712) | 1.73838564 |
| 85 | Hemivertebrae (HP:0002937) | 1.72933707 |
| 86 | Symptomatic seizures (HP:0011145) | 1.72850650 |
| 87 | Postnatal microcephaly (HP:0005484) | 1.72611027 |
| 88 | Absent septum pellucidum (HP:0001331) | 1.71553763 |
| 89 | Abnormal biliary tract morphology (HP:0012440) | 1.71128176 |
| 90 | Intestinal atresia (HP:0011100) | 1.70950066 |
| 91 | Exertional dyspnea (HP:0002875) | 1.70730567 |
| 92 | Increased nuchal translucency (HP:0010880) | 1.70510309 |
| 93 | Abnormality of alanine metabolism (HP:0010916) | 1.67966032 |
| 94 | Hyperalaninemia (HP:0003348) | 1.67966032 |
| 95 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 1.67966032 |
| 96 | Progressive inability to walk (HP:0002505) | 1.64957937 |
| 97 | Ectopic kidney (HP:0000086) | 1.64580292 |
| 98 | Breast carcinoma (HP:0003002) | 1.61397443 |
| 99 | Methylmalonic acidemia (HP:0002912) | 1.60933552 |
| 100 | Abnormality of the carotid arteries (HP:0005344) | 1.58599606 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | SRPK1 | 3.70873955 |
| 2 | CDC7 | 3.55548607 |
| 3 | WEE1 | 3.44208029 |
| 4 | BUB1 | 3.37068895 |
| 5 | TRIM28 | 3.31234642 |
| 6 | TSSK6 | 3.28064413 |
| 7 | MST4 | 3.10543606 |
| 8 | MKNK2 | 2.95079873 |
| 9 | PLK4 | 2.64483033 |
| 10 | BMPR1B | 2.64433877 |
| 11 | INSRR | 2.61552574 |
| 12 | MKNK1 | 2.43629453 |
| 13 | NEK1 | 2.43263132 |
| 14 | VRK2 | 2.30348455 |
| 15 | PLK3 | 2.24967608 |
| 16 | TTK | 2.24481061 |
| 17 | EIF2AK3 | 2.20161418 |
| 18 | ZAK | 2.11619003 |
| 19 | EIF2AK1 | 2.10120416 |
| 20 | PBK | 1.89323852 |
| 21 | NUAK1 | 1.88178735 |
| 22 | AKT3 | 1.87705586 |
| 23 | CASK | 1.75320011 |
| 24 | BRSK2 | 1.69852478 |
| 25 | WNK3 | 1.54769031 |
| 26 | NME1 | 1.52974240 |
| 27 | TNIK | 1.44570607 |
| 28 | ACVR1B | 1.38982281 |
| 29 | VRK1 | 1.35096597 |
| 30 | NEK2 | 1.28994382 |
| 31 | PLK1 | 1.25984212 |
| 32 | EIF2AK2 | 1.11131765 |
| 33 | PASK | 1.08465113 |
| 34 | TAF1 | 1.07610322 |
| 35 | ATR | 1.07589502 |
| 36 | PNCK | 1.07302694 |
| 37 | BCR | 1.05295107 |
| 38 | TGFBR1 | 1.01573169 |
| 39 | BRSK1 | 1.00573445 |
| 40 | PDK2 | 1.00365112 |
| 41 | CCNB1 | 0.99328495 |
| 42 | ERBB3 | 0.98075379 |
| 43 | PLK2 | 0.93060234 |
| 44 | AURKB | 0.92895672 |
| 45 | CHEK2 | 0.87037259 |
| 46 | STK16 | 0.84333305 |
| 47 | STK39 | 0.81881542 |
| 48 | DYRK3 | 0.80548745 |
| 49 | STK3 | 0.80072659 |
| 50 | CDK8 | 0.78620073 |
| 51 | CDK7 | 0.67202074 |
| 52 | MAPK13 | 0.63782398 |
| 53 | ATM | 0.63678491 |
| 54 | BRD4 | 0.63010332 |
| 55 | BCKDK | 0.60095319 |
| 56 | CHEK1 | 0.57672626 |
| 57 | WNK4 | 0.57351790 |
| 58 | ALK | 0.56750377 |
| 59 | SIK3 | 0.56407704 |
| 60 | ERBB4 | 0.55911726 |
| 61 | DYRK2 | 0.54583625 |
| 62 | CSNK1G1 | 0.54417307 |
| 63 | MAP4K2 | 0.54283220 |
| 64 | STK10 | 0.53500254 |
| 65 | RPS6KA4 | 0.52700713 |
| 66 | CSNK2A1 | 0.49809963 |
| 67 | PRKCG | 0.49130345 |
| 68 | BRAF | 0.48608945 |
| 69 | OXSR1 | 0.45557975 |
| 70 | ADRBK2 | 0.45151167 |
| 71 | MAPKAPK5 | 0.44553397 |
| 72 | CSNK2A2 | 0.43599580 |
| 73 | CSNK1G3 | 0.42069912 |
| 74 | CDK12 | 0.40942325 |
| 75 | NTRK2 | 0.40292055 |
| 76 | MAP3K8 | 0.40000197 |
| 77 | LATS1 | 0.39741716 |
| 78 | CSNK1G2 | 0.39106628 |
| 79 | STK24 | 0.38863915 |
| 80 | CSNK1E | 0.37984661 |
| 81 | TYK2 | 0.37945513 |
| 82 | AURKA | 0.37531297 |
| 83 | STK38L | 0.33991390 |
| 84 | STK4 | 0.32249164 |
| 85 | CDK1 | 0.32075936 |
| 86 | CDK3 | 0.32021834 |
| 87 | PRKCE | 0.31245480 |
| 88 | MAP2K7 | 0.29958443 |
| 89 | GRK1 | 0.29404062 |
| 90 | RPS6KA5 | 0.29378449 |
| 91 | NTRK3 | 0.28613922 |
| 92 | IGF1R | 0.26156183 |
| 93 | CDK2 | 0.25711172 |
| 94 | TIE1 | 0.25288604 |
| 95 | FRK | 0.25258729 |
| 96 | PRKCI | 0.25103974 |
| 97 | CSNK1A1 | 0.23173820 |
| 98 | CSNK1A1L | 0.22313668 |
| 99 | FGFR1 | 0.21435369 |
| 100 | FGR | 0.21048697 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 4.73022361 |
| 2 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.37065643 |
| 3 | DNA replication_Homo sapiens_hsa03030 | 2.95883226 |
| 4 | Non-homologous end-joining_Homo sapiens_hsa03450 | 2.89483169 |
| 5 | Mismatch repair_Homo sapiens_hsa03430 | 2.81154286 |
| 6 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.78123424 |
| 7 | Protein export_Homo sapiens_hsa03060 | 2.76444604 |
| 8 | Parkinsons disease_Homo sapiens_hsa05012 | 2.67352733 |
| 9 | Homologous recombination_Homo sapiens_hsa03440 | 2.64125656 |
| 10 | RNA polymerase_Homo sapiens_hsa03020 | 2.60924064 |
| 11 | Spliceosome_Homo sapiens_hsa03040 | 2.49065499 |
| 12 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 2.42222585 |
| 13 | RNA transport_Homo sapiens_hsa03013 | 2.25041572 |
| 14 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 2.24944784 |
| 15 | Basal transcription factors_Homo sapiens_hsa03022 | 2.20999976 |
| 16 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 2.19809650 |
| 17 | Cell cycle_Homo sapiens_hsa04110 | 2.14979704 |
| 18 | Ribosome_Homo sapiens_hsa03010 | 2.03938825 |
| 19 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.03242331 |
| 20 | Steroid biosynthesis_Homo sapiens_hsa00100 | 2.03136929 |
| 21 | Base excision repair_Homo sapiens_hsa03410 | 2.02507829 |
| 22 | Huntingtons disease_Homo sapiens_hsa05016 | 2.00437067 |
| 23 | RNA degradation_Homo sapiens_hsa03018 | 1.92675831 |
| 24 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.91157350 |
| 25 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.73861248 |
| 26 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.69757411 |
| 27 | Alzheimers disease_Homo sapiens_hsa05010 | 1.61768300 |
| 28 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.61347091 |
| 29 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 1.51619166 |
| 30 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.40732534 |
| 31 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.32025216 |
| 32 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.30789074 |
| 33 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.30592590 |
| 34 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.30190578 |
| 35 | Purine metabolism_Homo sapiens_hsa00230 | 1.27278763 |
| 36 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.17105947 |
| 37 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 1.16700834 |
| 38 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.12522763 |
| 39 | Nicotine addiction_Homo sapiens_hsa05033 | 1.04559266 |
| 40 | Oocyte meiosis_Homo sapiens_hsa04114 | 1.02233164 |
| 41 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.99617675 |
| 42 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.99229492 |
| 43 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.94652456 |
| 44 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.94306741 |
| 45 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.91147961 |
| 46 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.86240130 |
| 47 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.78838512 |
| 48 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.77551369 |
| 49 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.75765824 |
| 50 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.71433356 |
| 51 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.71047180 |
| 52 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.64233037 |
| 53 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.63461775 |
| 54 | Metabolic pathways_Homo sapiens_hsa01100 | 0.58044484 |
| 55 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.57162264 |
| 56 | Phototransduction_Homo sapiens_hsa04744 | 0.56937102 |
| 57 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.56921204 |
| 58 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.56818530 |
| 59 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.56338601 |
| 60 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.54429774 |
| 61 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.54251160 |
| 62 | Carbon metabolism_Homo sapiens_hsa01200 | 0.54086063 |
| 63 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.53536495 |
| 64 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.53217323 |
| 65 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.52297243 |
| 66 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.46974084 |
| 67 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.46002529 |
| 68 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.42379253 |
| 69 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.42228363 |
| 70 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.39331913 |
| 71 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.36656082 |
| 72 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.35673233 |
| 73 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.34287883 |
| 74 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.34062334 |
| 75 | Taste transduction_Homo sapiens_hsa04742 | 0.34054953 |
| 76 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.32389756 |
| 77 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.31939810 |
| 78 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.31389917 |
| 79 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.30113016 |
| 80 | Olfactory transduction_Homo sapiens_hsa04740 | 0.28541958 |
| 81 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.28439365 |
| 82 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.27924858 |
| 83 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.27888333 |
| 84 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.27298582 |
| 85 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.23783628 |
| 86 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.21432769 |
| 87 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.20437982 |
| 88 | Retinol metabolism_Homo sapiens_hsa00830 | 0.20046164 |
| 89 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.19511200 |
| 90 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.19496213 |
| 91 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.19008129 |
| 92 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.17736002 |
| 93 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.16936231 |
| 94 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.16933224 |
| 95 | Peroxisome_Homo sapiens_hsa04146 | 0.14079878 |
| 96 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.13827960 |
| 97 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.12900926 |
| 98 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.11249423 |
| 99 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.09740938 |
| 100 | Lysine degradation_Homo sapiens_hsa00310 | 0.09327914 |

