DBF4P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA double-strand break processing (GO:0000729)5.62012968
2CENP-A containing nucleosome assembly (GO:0034080)5.52018722
3chromatin remodeling at centromere (GO:0031055)5.48828580
4proteasome assembly (GO:0043248)5.33590807
5protein localization to kinetochore (GO:0034501)5.03174253
6histone exchange (GO:0043486)4.82449398
7lens fiber cell differentiation (GO:0070306)4.40986756
8DNA replication checkpoint (GO:0000076)4.33178454
9peptidyl-histidine modification (GO:0018202)4.23388517
10DNA replication-independent nucleosome organization (GO:0034724)4.20590997
11DNA replication-independent nucleosome assembly (GO:0006336)4.20590997
12mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.20582177
13kinetochore organization (GO:0051383)4.20286945
14DNA ligation (GO:0006266)4.14889267
15mitotic metaphase plate congression (GO:0007080)4.14116708
16negative regulation of DNA-dependent DNA replication (GO:2000104)4.06039360
17dopaminergic neuron differentiation (GO:0071542)4.04945118
18negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.02922667
19regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.01941369
20protein localization to chromosome, centromeric region (GO:0071459)4.01124225
21replication fork processing (GO:0031297)3.96882581
22anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.90816611
23kinetochore assembly (GO:0051382)3.88264722
24positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.79709382
25establishment of protein localization to mitochondrial membrane (GO:0090151)3.77043125
26regulation of nuclear cell cycle DNA replication (GO:0033262)3.74959393
27DNA catabolic process, exonucleolytic (GO:0000738)3.64361853
28termination of RNA polymerase I transcription (GO:0006363)3.63976837
29regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.63461514
30regulation of mitotic spindle checkpoint (GO:1903504)3.63461514
31lens morphogenesis in camera-type eye (GO:0002089)3.59398296
32transcription elongation from RNA polymerase I promoter (GO:0006362)3.58346053
33negative regulation of transcription regulatory region DNA binding (GO:2000678)3.57862106
34mitochondrial respiratory chain complex assembly (GO:0033108)3.56906233
35negative regulation of ligase activity (GO:0051352)3.56306494
36negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.56306494
37negative regulation of fibroblast apoptotic process (GO:2000270)3.54273866
38ribosome assembly (GO:0042255)3.53465540
39metaphase plate congression (GO:0051310)3.47492275
40signal peptide processing (GO:0006465)3.46343260
41energy coupled proton transport, down electrochemical gradient (GO:0015985)3.40448955
42ATP synthesis coupled proton transport (GO:0015986)3.40448955
43maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.40248780
44signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.40164405
45signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.40164405
46signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.40164405
47protein complex biogenesis (GO:0070271)3.40150565
48mitotic G2/M transition checkpoint (GO:0044818)3.39582986
49DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.38838650
50IMP biosynthetic process (GO:0006188)3.38443395
51transcription initiation from RNA polymerase I promoter (GO:0006361)3.37536063
52establishment of integrated proviral latency (GO:0075713)3.37473825
53spindle checkpoint (GO:0031577)3.35884307
54signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.35275195
55intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.35275195
56mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.33102631
57mitochondrial respiratory chain complex I assembly (GO:0032981)3.33102631
58NADH dehydrogenase complex assembly (GO:0010257)3.33102631
59exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.31561371
60mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.27877830
61regulation of centriole replication (GO:0046599)3.26251169
62signal transduction involved in DNA damage checkpoint (GO:0072422)3.25719948
63signal transduction involved in DNA integrity checkpoint (GO:0072401)3.25719948
64pseudouridine synthesis (GO:0001522)3.25165678
65positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.24852243
66regulation of cellular amino acid metabolic process (GO:0006521)3.24349126
67signal transduction involved in cell cycle checkpoint (GO:0072395)3.23164948
68purine nucleobase biosynthetic process (GO:0009113)3.22284071
69nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.17541524
70regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.15231784
71positive regulation of ligase activity (GO:0051351)3.14691102
72DNA strand elongation involved in DNA replication (GO:0006271)3.13793913
73nucleobase biosynthetic process (GO:0046112)3.13387253
74mitotic spindle checkpoint (GO:0071174)3.12996336
75DNA strand renaturation (GO:0000733)3.12974906
76RNA-dependent DNA replication (GO:0006278)3.12889470
77transcription from RNA polymerase I promoter (GO:0006360)3.09215473
78termination of RNA polymerase II transcription (GO:0006369)3.09102171
79negative regulation of mitotic sister chromatid separation (GO:2000816)3.06761779
80negative regulation of sister chromatid segregation (GO:0033046)3.06761779
81negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.06761779
82negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.06761779
83negative regulation of mitotic sister chromatid segregation (GO:0033048)3.06761779
84mitotic sister chromatid segregation (GO:0000070)3.06065527
85sister chromatid segregation (GO:0000819)3.05197936
86telomere maintenance via telomerase (GO:0007004)3.03065680
87regulation of DNA methylation (GO:0044030)3.02947804
88DNA replication-dependent nucleosome organization (GO:0034723)3.02606025
89DNA replication-dependent nucleosome assembly (GO:0006335)3.02606025
90DNA-templated transcription, termination (GO:0006353)3.01686513
91centriole replication (GO:0007099)3.01623355
92chaperone-mediated protein transport (GO:0072321)3.01582161
93DNA strand elongation (GO:0022616)3.01514898
94respiratory electron transport chain (GO:0022904)3.00311233
95negative regulation of chromosome segregation (GO:0051985)2.99565035
96resolution of meiotic recombination intermediates (GO:0000712)2.98885117
97regulation of ubiquitin-protein transferase activity (GO:0051438)2.98656179
98respiratory chain complex IV assembly (GO:0008535)2.97863445
99midbrain development (GO:0030901)2.94464104
100G1/S transition of mitotic cell cycle (GO:0000082)2.93295747

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.62764925
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.67314475
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.92259131
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.91909633
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.88298756
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.79638299
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.12413626
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.10969953
9CREB1_15753290_ChIP-ChIP_HEK293T_Human2.93608460
10ELK1_19687146_ChIP-ChIP_HELA_Human2.72490626
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.71240248
12AR_21909140_ChIP-Seq_LNCAP_Human2.68613897
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.66457180
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.63167400
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.54074738
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.45200074
17VDR_23849224_ChIP-Seq_CD4+_Human2.36457374
18MYC_19030024_ChIP-ChIP_MESCs_Mouse2.10306607
19PADI4_21655091_ChIP-ChIP_MCF-7_Human2.08977808
20KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.03894705
21MYC_19079543_ChIP-ChIP_MESCs_Mouse2.02306216
22FOXP3_21729870_ChIP-Seq_TREG_Human2.02278422
23VDR_22108803_ChIP-Seq_LS180_Human2.02188636
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.97744331
25ZNF274_21170338_ChIP-Seq_K562_Hela1.95776499
26SALL1_21062744_ChIP-ChIP_HESCs_Human1.92142558
27HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.90998041
28EWS_26573619_Chip-Seq_HEK293_Human1.84130232
29FUS_26573619_Chip-Seq_HEK293_Human1.82593210
30PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.82125872
31MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.75008612
32DCP1A_22483619_ChIP-Seq_HELA_Human1.74186627
33MYC_18358816_ChIP-ChIP_MESCs_Mouse1.72076716
34NELFA_20434984_ChIP-Seq_ESCs_Mouse1.71056774
35EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.69624426
36FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.69506902
37E2F1_21310950_ChIP-Seq_MCF-7_Human1.66109588
38NOTCH1_21737748_ChIP-Seq_TLL_Human1.63029548
39YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.62996963
40FLI1_27457419_Chip-Seq_LIVER_Mouse1.61257137
41POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.58321679
42MYC_18940864_ChIP-ChIP_HL60_Human1.55455791
43E2F1_18555785_ChIP-Seq_MESCs_Mouse1.54793971
44TAF15_26573619_Chip-Seq_HEK293_Human1.51667518
45POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.50047781
46TTF2_22483619_ChIP-Seq_HELA_Human1.49464795
47POU5F1_16153702_ChIP-ChIP_HESCs_Human1.47964797
48THAP11_20581084_ChIP-Seq_MESCs_Mouse1.47282703
49SRF_21415370_ChIP-Seq_HL-1_Mouse1.44147264
50GABP_19822575_ChIP-Seq_HepG2_Human1.43429641
51MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.42220136
52HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.40508526
53HOXB4_20404135_ChIP-ChIP_EML_Mouse1.40274092
54PCGF2_27294783_Chip-Seq_ESCs_Mouse1.37203741
55TP63_19390658_ChIP-ChIP_HaCaT_Human1.34914213
56P300_19829295_ChIP-Seq_ESCs_Human1.34819203
57MYCN_18555785_ChIP-Seq_MESCs_Mouse1.33605526
58POU3F2_20337985_ChIP-ChIP_501MEL_Human1.32340205
59NANOG_16153702_ChIP-ChIP_HESCs_Human1.30080616
60DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.26332540
61XRN2_22483619_ChIP-Seq_HELA_Human1.25910426
62ELF1_17652178_ChIP-ChIP_JURKAT_Human1.25384358
63PCGF2_27294783_Chip-Seq_NPCs_Mouse1.23005013
64SOX2_18555785_ChIP-Seq_MESCs_Mouse1.22937435
65NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.22614252
66ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.19270725
67CTBP1_25329375_ChIP-Seq_LNCAP_Human1.17129329
68CTBP2_25329375_ChIP-Seq_LNCAP_Human1.16941202
69ZFP57_27257070_Chip-Seq_ESCs_Mouse1.12596807
70ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.11724747
71SOX2_16153702_ChIP-ChIP_HESCs_Human1.11050043
72CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.10214138
73SUZ12_27294783_Chip-Seq_NPCs_Mouse1.08523096
74IGF1R_20145208_ChIP-Seq_DFB_Human1.07408415
75EZH2_27294783_Chip-Seq_NPCs_Mouse1.06733592
76MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.05053306
77NANOG_18555785_ChIP-Seq_MESCs_Mouse1.04021240
78NFE2_27457419_Chip-Seq_LIVER_Mouse1.02516419
79HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.02104406
80PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.99190084
81ER_23166858_ChIP-Seq_MCF-7_Human0.96224879
82CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.95187166
83RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93896227
84GATA1_26923725_Chip-Seq_HPCs_Mouse0.93163932
85YY1_21170310_ChIP-Seq_MESCs_Mouse0.93025640
86RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.89055082
87UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.86329741
88TP53_22573176_ChIP-Seq_HFKS_Human0.86101708
89E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.85454400
90TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82821539
91POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.82821539
92SMAD3_21741376_ChIP-Seq_EPCs_Human0.82386366
93EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.81654215
94CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.81075833
95SUZ12_18555785_Chip-Seq_ESCs_Mouse0.80074063
96TOP2B_26459242_ChIP-Seq_MCF-7_Human0.79853212
97LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.78179438
98BCAT_22108803_ChIP-Seq_LS180_Human0.78018399
99SOX2_19829295_ChIP-Seq_ESCs_Human0.77835321
100NANOG_19829295_ChIP-Seq_ESCs_Human0.77835321

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001346_abnormal_lacrimal_gland5.05551682
2MP0000569_abnormal_digit_pigmentation3.67243762
3MP0010094_abnormal_chromosome_stability3.59362637
4MP0000566_synostosis3.58680984
5MP0009697_abnormal_copulation3.33912245
6MP0008057_abnormal_DNA_replication3.29499119
7MP0004957_abnormal_blastocyst_morpholog3.18496799
8MP0003693_abnormal_embryo_hatching3.07774668
9MP0003111_abnormal_nucleus_morphology2.82804218
10MP0008058_abnormal_DNA_repair2.68963065
11MP0003077_abnormal_cell_cycle2.66470073
12MP0006292_abnormal_olfactory_placode2.52781814
13MP0002735_abnormal_chemical_nociception2.45510918
14MP0000372_irregular_coat_pigmentation2.34473385
15MP0003890_abnormal_embryonic-extraembry2.29956681
16MP0001905_abnormal_dopamine_level2.26994814
17MP0001529_abnormal_vocalization2.26596964
18MP0002102_abnormal_ear_morphology2.22142378
19MP0003937_abnormal_limbs/digits/tail_de2.07270632
20MP0002938_white_spotting1.97290176
21MP0008932_abnormal_embryonic_tissue1.94741544
22MP0003786_premature_aging1.73496347
23MP0003718_maternal_effect1.66409316
24MP0006035_abnormal_mitochondrial_morpho1.64611500
25MP0008789_abnormal_olfactory_epithelium1.63915532
26MP0001188_hyperpigmentation1.61083956
27MP0008007_abnormal_cellular_replicative1.57602271
28MP0004215_abnormal_myocardial_fiber1.55696452
29MP0001299_abnormal_eye_distance/1.53515302
30MP0006072_abnormal_retinal_apoptosis1.49177577
31MP0002638_abnormal_pupillary_reflex1.48606787
32MP0001293_anophthalmia1.44214081
33MP0003123_paternal_imprinting1.39925220
34MP0002736_abnormal_nociception_after1.38674503
35MP0003938_abnormal_ear_development1.37355876
36MP0003283_abnormal_digestive_organ1.36621161
37MP0003567_abnormal_fetal_cardiomyocyte1.31085880
38MP0001286_abnormal_eye_development1.29538840
39MP0000049_abnormal_middle_ear1.29179955
40MP0002234_abnormal_pharynx_morphology1.28723945
41MP0003136_yellow_coat_color1.26942698
42MP0001968_abnormal_touch/_nociception1.24295588
43MP0003119_abnormal_digestive_system1.19380325
44MP0005394_taste/olfaction_phenotype1.17739028
45MP0005499_abnormal_olfactory_system1.17739028
46MP0002751_abnormal_autonomic_nervous1.15654699
47MP0001177_atelectasis1.13695543
48MP0003959_abnormal_lean_body1.13219355
49MP0006054_spinal_hemorrhage1.12688338
50MP0002734_abnormal_mechanical_nocicepti1.10593490
51MP0000350_abnormal_cell_proliferation1.09519130
52MP0003941_abnormal_skin_development1.07878794
53MP0004147_increased_porphyrin_level1.07755675
54MP0008877_abnormal_DNA_methylation1.06230863
55MP0002697_abnormal_eye_size1.03745522
56MP0002111_abnormal_tail_morphology1.03545733
57MP0005670_abnormal_white_adipose1.01108242
58MP0008872_abnormal_physiological_respon1.00286553
59MP0009672_abnormal_birth_weight1.00045830
60MP0006036_abnormal_mitochondrial_physio0.98820867
61MP0001697_abnormal_embryo_size0.95267645
62MP0005084_abnormal_gallbladder_morpholo0.94375972
63MP0001672_abnormal_embryogenesis/_devel0.93772092
64MP0005380_embryogenesis_phenotype0.93772092
65MP0002733_abnormal_thermal_nociception0.92958204
66MP0002233_abnormal_nose_morphology0.92313079
67MP0002282_abnormal_trachea_morphology0.91316255
68MP0001485_abnormal_pinna_reflex0.90227572
69MP0001730_embryonic_growth_arrest0.88129801
70MP0002132_abnormal_respiratory_system0.87089247
71MP0001984_abnormal_olfaction0.86092901
72MP0001929_abnormal_gametogenesis0.84683230
73MP0005391_vision/eye_phenotype0.83217458
74MP0003121_genomic_imprinting0.82646288
75MP0005551_abnormal_eye_electrophysiolog0.81814559
76MP0002085_abnormal_embryonic_tissue0.78972337
77MP0002210_abnormal_sex_determination0.77976896
78MP0002084_abnormal_developmental_patter0.75599032
79MP0002653_abnormal_ependyma_morphology0.75528032
80MP0002092_abnormal_eye_morphology0.74647219
81MP0003137_abnormal_impulse_conducting0.74209584
82MP0001324_abnormal_eye_pigmentation0.73270106
83MP0001486_abnormal_startle_reflex0.71839498
84MP0005365_abnormal_bile_salt0.71100834
85MP0009053_abnormal_anal_canal0.70707672
86MP0002088_abnormal_embryonic_growth/wei0.70003319
87MP0003984_embryonic_growth_retardation0.69689042
88MP0005253_abnormal_eye_physiology0.69317360
89MP0002080_prenatal_lethality0.67874764
90MP0003698_abnormal_male_reproductive0.65853911
91MP0003943_abnormal_hepatobiliary_system0.65427698
92MP0005197_abnormal_uvea_morphology0.64992941
93MP0002277_abnormal_respiratory_mucosa0.64516414
94MP0001119_abnormal_female_reproductive0.64393840
95MP0000313_abnormal_cell_death0.63563342
96MP0004197_abnormal_fetal_growth/weight/0.63481103
97MP0008995_early_reproductive_senescence0.63214542
98MP0009250_abnormal_appendicular_skeleto0.62465352
99MP0005195_abnormal_posterior_eye0.61841461
100MP0003755_abnormal_palate_morphology0.61200613

Predicted human phenotypes

RankGene SetZ-score
1Progressive macrocephaly (HP:0004481)4.59970720
2Acute necrotizing encephalopathy (HP:0006965)4.54609543
3Abnormal mitochondria in muscle tissue (HP:0008316)4.36872041
4Hepatocellular necrosis (HP:0001404)3.95933304
5Acute encephalopathy (HP:0006846)3.82574265
6Mitochondrial inheritance (HP:0001427)3.74720479
7Increased CSF lactate (HP:0002490)3.42957036
8Birth length less than 3rd percentile (HP:0003561)3.42004392
9Increased hepatocellular lipid droplets (HP:0006565)3.37892380
10Anterior segment dysgenesis (HP:0007700)3.36150312
11Hepatic necrosis (HP:0002605)3.30681822
12Meckel diverticulum (HP:0002245)3.23094344
13Cerebral edema (HP:0002181)3.10775417
14Abnormality of the ileum (HP:0001549)3.08791106
15Lipid accumulation in hepatocytes (HP:0006561)3.07171999
16Small intestinal stenosis (HP:0012848)3.05044585
17Duodenal stenosis (HP:0100867)3.05044585
18Volvulus (HP:0002580)2.95218295
19Congenital, generalized hypertrichosis (HP:0004540)2.94735312
20Aplasia/Hypoplasia of the uvula (HP:0010293)2.92371334
21Embryonal renal neoplasm (HP:0011794)2.90977589
22Abnormality of chromosome stability (HP:0003220)2.83650149
23Stomach cancer (HP:0012126)2.73654081
24Abnormality of the duodenum (HP:0002246)2.73334584
25Short middle phalanx of the 5th finger (HP:0004220)2.70621190
26Biliary tract neoplasm (HP:0100574)2.68599937
27Abnormality of the labia minora (HP:0012880)2.65482133
28Abnormality of the septum pellucidum (HP:0007375)2.61741221
29Nephroblastoma (Wilms tumor) (HP:0002667)2.61574562
30Abnormality of the preputium (HP:0100587)2.58647065
31Abnormal lung lobation (HP:0002101)2.53944531
32Nephronophthisis (HP:0000090)2.49214758
33Hyperinsulinemic hypoglycemia (HP:0000825)2.48481576
34Increased serum lactate (HP:0002151)2.47380382
35Increased intramyocellular lipid droplets (HP:0012240)2.46357715
36Cortical dysplasia (HP:0002539)2.44899836
37Pancreatic islet-cell hyperplasia (HP:0004510)2.40535158
38Neoplasm of the colon (HP:0100273)2.39645850
39Respiratory difficulties (HP:0002880)2.33456570
40Optic disc pallor (HP:0000543)2.30729061
41Triphalangeal thumb (HP:0001199)2.29456937
42Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.26937381
43Leukodystrophy (HP:0002415)2.24502049
44Pancreatic cysts (HP:0001737)2.21723910
45Hypoglycemic seizures (HP:0002173)2.17827203
46Respiratory failure (HP:0002878)2.17069864
47Renal Fanconi syndrome (HP:0001994)2.16736930
48Acanthocytosis (HP:0001927)2.15859343
49Chromsome breakage (HP:0040012)2.12737660
50Septo-optic dysplasia (HP:0100842)2.12539941
51Conjunctival hamartoma (HP:0100780)2.11567311
52Chromosomal breakage induced by crosslinking agents (HP:0003221)2.07245511
53Supernumerary spleens (HP:0009799)2.06317854
54Neoplasm of the small intestine (HP:0100833)2.05791368
55Lactic acidosis (HP:0003128)2.05045062
56Arteriovenous malformation (HP:0100026)2.02581676
57Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.02462691
58Neoplasm of the rectum (HP:0100743)2.02302510
59Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.01286644
60Horseshoe kidney (HP:0000085)2.00884474
61Absent radius (HP:0003974)1.98583647
62Exercise intolerance (HP:0003546)1.97610037
63Megalencephaly (HP:0001355)1.96556777
64Sloping forehead (HP:0000340)1.94160643
65Delayed CNS myelination (HP:0002188)1.92936113
66Clubbing of toes (HP:0100760)1.92115686
67Colon cancer (HP:0003003)1.91600073
68Increased muscle lipid content (HP:0009058)1.91254066
69Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.90601015
70Absent forearm bone (HP:0003953)1.88450190
71Aplasia involving forearm bones (HP:0009822)1.88450190
72Ovarian neoplasm (HP:0100615)1.88237613
73CNS demyelination (HP:0007305)1.87744350
74Myelodysplasia (HP:0002863)1.87049157
75Macrocytic anemia (HP:0001972)1.82747335
76Abnormality of the phalanges of the 5th finger (HP:0004213)1.82140535
77Hypoglycemic coma (HP:0001325)1.79827410
78X-linked dominant inheritance (HP:0001423)1.78250468
79Abnormality of the renal medulla (HP:0100957)1.77952366
80Abnormality of midbrain morphology (HP:0002418)1.75778523
81Molar tooth sign on MRI (HP:0002419)1.75778523
82Tubular atrophy (HP:0000092)1.75458069
83Carpal bone hypoplasia (HP:0001498)1.74778540
84Emotional lability (HP:0000712)1.73838564
85Hemivertebrae (HP:0002937)1.72933707
86Symptomatic seizures (HP:0011145)1.72850650
87Postnatal microcephaly (HP:0005484)1.72611027
88Absent septum pellucidum (HP:0001331)1.71553763
89Abnormal biliary tract morphology (HP:0012440)1.71128176
90Intestinal atresia (HP:0011100)1.70950066
91Exertional dyspnea (HP:0002875)1.70730567
92Increased nuchal translucency (HP:0010880)1.70510309
93Abnormality of alanine metabolism (HP:0010916)1.67966032
94Hyperalaninemia (HP:0003348)1.67966032
95Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.67966032
96Progressive inability to walk (HP:0002505)1.64957937
97Ectopic kidney (HP:0000086)1.64580292
98Breast carcinoma (HP:0003002)1.61397443
99Methylmalonic acidemia (HP:0002912)1.60933552
100Abnormality of the carotid arteries (HP:0005344)1.58599606

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SRPK13.70873955
2CDC73.55548607
3WEE13.44208029
4BUB13.37068895
5TRIM283.31234642
6TSSK63.28064413
7MST43.10543606
8MKNK22.95079873
9PLK42.64483033
10BMPR1B2.64433877
11INSRR2.61552574
12MKNK12.43629453
13NEK12.43263132
14VRK22.30348455
15PLK32.24967608
16TTK2.24481061
17EIF2AK32.20161418
18ZAK2.11619003
19EIF2AK12.10120416
20PBK1.89323852
21NUAK11.88178735
22AKT31.87705586
23CASK1.75320011
24BRSK21.69852478
25WNK31.54769031
26NME11.52974240
27TNIK1.44570607
28ACVR1B1.38982281
29VRK11.35096597
30NEK21.28994382
31PLK11.25984212
32EIF2AK21.11131765
33PASK1.08465113
34TAF11.07610322
35ATR1.07589502
36PNCK1.07302694
37BCR1.05295107
38TGFBR11.01573169
39BRSK11.00573445
40PDK21.00365112
41CCNB10.99328495
42ERBB30.98075379
43PLK20.93060234
44AURKB0.92895672
45CHEK20.87037259
46STK160.84333305
47STK390.81881542
48DYRK30.80548745
49STK30.80072659
50CDK80.78620073
51CDK70.67202074
52MAPK130.63782398
53ATM0.63678491
54BRD40.63010332
55BCKDK0.60095319
56CHEK10.57672626
57WNK40.57351790
58ALK0.56750377
59SIK30.56407704
60ERBB40.55911726
61DYRK20.54583625
62CSNK1G10.54417307
63MAP4K20.54283220
64STK100.53500254
65RPS6KA40.52700713
66CSNK2A10.49809963
67PRKCG0.49130345
68BRAF0.48608945
69OXSR10.45557975
70ADRBK20.45151167
71MAPKAPK50.44553397
72CSNK2A20.43599580
73CSNK1G30.42069912
74CDK120.40942325
75NTRK20.40292055
76MAP3K80.40000197
77LATS10.39741716
78CSNK1G20.39106628
79STK240.38863915
80CSNK1E0.37984661
81TYK20.37945513
82AURKA0.37531297
83STK38L0.33991390
84STK40.32249164
85CDK10.32075936
86CDK30.32021834
87PRKCE0.31245480
88MAP2K70.29958443
89GRK10.29404062
90RPS6KA50.29378449
91NTRK30.28613922
92IGF1R0.26156183
93CDK20.25711172
94TIE10.25288604
95FRK0.25258729
96PRKCI0.25103974
97CSNK1A10.23173820
98CSNK1A1L0.22313668
99FGFR10.21435369
100FGR0.21048697

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.73022361
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.37065643
3DNA replication_Homo sapiens_hsa030302.95883226
4Non-homologous end-joining_Homo sapiens_hsa034502.89483169
5Mismatch repair_Homo sapiens_hsa034302.81154286
6Oxidative phosphorylation_Homo sapiens_hsa001902.78123424
7Protein export_Homo sapiens_hsa030602.76444604
8Parkinsons disease_Homo sapiens_hsa050122.67352733
9Homologous recombination_Homo sapiens_hsa034402.64125656
10RNA polymerase_Homo sapiens_hsa030202.60924064
11Spliceosome_Homo sapiens_hsa030402.49065499
12Fanconi anemia pathway_Homo sapiens_hsa034602.42222585
13RNA transport_Homo sapiens_hsa030132.25041572
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.24944784
15Basal transcription factors_Homo sapiens_hsa030222.20999976
16Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.19809650
17Cell cycle_Homo sapiens_hsa041102.14979704
18Ribosome_Homo sapiens_hsa030102.03938825
19Nucleotide excision repair_Homo sapiens_hsa034202.03242331
20Steroid biosynthesis_Homo sapiens_hsa001002.03136929
21Base excision repair_Homo sapiens_hsa034102.02507829
22Huntingtons disease_Homo sapiens_hsa050162.00437067
23RNA degradation_Homo sapiens_hsa030181.92675831
24One carbon pool by folate_Homo sapiens_hsa006701.91157350
25Propanoate metabolism_Homo sapiens_hsa006401.73861248
26Selenocompound metabolism_Homo sapiens_hsa004501.69757411
27Alzheimers disease_Homo sapiens_hsa050101.61768300
28Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.61347091
29mRNA surveillance pathway_Homo sapiens_hsa030151.51619166
30Pyrimidine metabolism_Homo sapiens_hsa002401.40732534
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.32025216
32Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.30789074
33Pyruvate metabolism_Homo sapiens_hsa006201.30592590
34Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.30190578
35Purine metabolism_Homo sapiens_hsa002301.27278763
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.17105947
37Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.16700834
38Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.12522763
39Nicotine addiction_Homo sapiens_hsa050331.04559266
40Oocyte meiosis_Homo sapiens_hsa041141.02233164
412-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.99617675
42Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.99229492
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.94652456
44p53 signaling pathway_Homo sapiens_hsa041150.94306741
45Fatty acid elongation_Homo sapiens_hsa000620.91147961
46Cardiac muscle contraction_Homo sapiens_hsa042600.86240130
47Butanoate metabolism_Homo sapiens_hsa006500.78838512
48Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.77551369
49Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.75765824
50Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.71433356
51Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.71047180
52Vitamin B6 metabolism_Homo sapiens_hsa007500.64233037
53N-Glycan biosynthesis_Homo sapiens_hsa005100.63461775
54Metabolic pathways_Homo sapiens_hsa011000.58044484
55Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.57162264
56Phototransduction_Homo sapiens_hsa047440.56937102
57Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.56921204
58Folate biosynthesis_Homo sapiens_hsa007900.56818530
59Caffeine metabolism_Homo sapiens_hsa002320.56338601
60Pentose and glucuronate interconversions_Homo sapiens_hsa000400.54429774
61Glutathione metabolism_Homo sapiens_hsa004800.54251160
62Carbon metabolism_Homo sapiens_hsa012000.54086063
63Biosynthesis of amino acids_Homo sapiens_hsa012300.53536495
64Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.53217323
65Epstein-Barr virus infection_Homo sapiens_hsa051690.52297243
66beta-Alanine metabolism_Homo sapiens_hsa004100.46974084
67Linoleic acid metabolism_Homo sapiens_hsa005910.46002529
68Tryptophan metabolism_Homo sapiens_hsa003800.42379253
69Primary immunodeficiency_Homo sapiens_hsa053400.42228363
70Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.39331913
71Sulfur metabolism_Homo sapiens_hsa009200.36656082
72Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.35673233
73Regulation of autophagy_Homo sapiens_hsa041400.34287883
74Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.34062334
75Taste transduction_Homo sapiens_hsa047420.34054953
76Hedgehog signaling pathway_Homo sapiens_hsa043400.32389756
77Fatty acid metabolism_Homo sapiens_hsa012120.31939810
78TGF-beta signaling pathway_Homo sapiens_hsa043500.31389917
79Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.30113016
80Olfactory transduction_Homo sapiens_hsa047400.28541958
81Drug metabolism - other enzymes_Homo sapiens_hsa009830.28439365
82alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.27924858
83Fatty acid degradation_Homo sapiens_hsa000710.27888333
84Basal cell carcinoma_Homo sapiens_hsa052170.27298582
85Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.23783628
86Fat digestion and absorption_Homo sapiens_hsa049750.21432769
87Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.20437982
88Retinol metabolism_Homo sapiens_hsa008300.20046164
89Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.19511200
90Wnt signaling pathway_Homo sapiens_hsa043100.19496213
91Hippo signaling pathway_Homo sapiens_hsa043900.19008129
92Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.17736002
93Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.16936231
94Vitamin digestion and absorption_Homo sapiens_hsa049770.16933224
95Peroxisome_Homo sapiens_hsa041460.14079878
96Chemical carcinogenesis_Homo sapiens_hsa052040.13827960
97Ether lipid metabolism_Homo sapiens_hsa005650.12900926
98Systemic lupus erythematosus_Homo sapiens_hsa053220.11249423
99Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.09740938
100Lysine degradation_Homo sapiens_hsa003100.09327914

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