DBH

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an oxidoreductase belonging to the copper type II, ascorbate-dependent monooxygenase family. It is present in the synaptic vesicles of postganglionic sympathetic neurons and converts dopamine to norepinephrine. It exists in both soluble and membrane-bound forms, depending on the absence or presence, respectively, of a signal peptide. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of glomerulus development (GO:0090193)9.22040543
2positive regulation of cell size (GO:0045793)9.05439628
3cell migration involved in heart development (GO:0060973)8.96662298
4peripheral nervous system neuron development (GO:0048935)8.68083766
5catecholamine transport (GO:0051937)7.69832781
6tongue development (GO:0043586)7.52191571
7synaptic transmission, cholinergic (GO:0007271)7.47260314
8response to water (GO:0009415)6.60355379
9regulation of cell maturation (GO:1903429)6.51583341
10suckling behavior (GO:0001967)6.14658118
11negative regulation of microtubule polymerization (GO:0031115)5.99963274
12positive regulation of synaptic transmission, dopaminergic (GO:0032226)5.96205573
13cellular response to nicotine (GO:0071316)5.93218552
14* dopamine metabolic process (GO:0042417)5.90360646
15alkaloid metabolic process (GO:0009820)5.89930035
16C21-steroid hormone biosynthetic process (GO:0006700)5.89504975
17neural crest cell migration (GO:0001755)5.87357909
18positive regulation of potassium ion transmembrane transporter activity (GO:1901018)5.83974120
19regulation of glomerulus development (GO:0090192)5.83125682
20dopamine biosynthetic process (GO:0042416)5.80424056
21negative regulation of cytosolic calcium ion concentration (GO:0051481)5.75308580
22auditory behavior (GO:0031223)5.52712348
23innervation (GO:0060384)5.48467561
24neuromuscular synaptic transmission (GO:0007274)5.41709443
25toxin metabolic process (GO:0009404)5.40742540
26regulation of cell proliferation involved in heart morphogenesis (GO:2000136)5.33255940
27neurotransmitter biosynthetic process (GO:0042136)5.29994710
28positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)5.27109777
29dopaminergic neuron differentiation (GO:0071542)5.22660229
30oxygen transport (GO:0015671)5.16794042
31mesenchymal cell proliferation (GO:0010463)5.14979831
32regulation of heart morphogenesis (GO:2000826)5.13358499
33* catecholamine biosynthetic process (GO:0042423)5.05792191
34* catechol-containing compound biosynthetic process (GO:0009713)5.05792191
35neuron cell-cell adhesion (GO:0007158)5.04475845
36response to nerve growth factor (GO:1990089)5.04437076
37cellular response to nerve growth factor stimulus (GO:1990090)5.04437076
38positive regulation of metanephros development (GO:0072216)4.89313001
39regulation of cardioblast proliferation (GO:0003264)4.76607976
40regulation of secondary heart field cardioblast proliferation (GO:0003266)4.76607976
41cell migration in hindbrain (GO:0021535)4.72656854
42monoamine transport (GO:0015844)4.62086166
43adult heart development (GO:0007512)4.58699808
44response to nicotine (GO:0035094)4.51803280
45* catecholamine metabolic process (GO:0006584)4.46317847
46* catechol-containing compound metabolic process (GO:0009712)4.46317847
47apoptotic process involved in development (GO:1902742)4.45804216
48neuron maturation (GO:0042551)4.45193900
49proline transport (GO:0015824)4.40863829
50embryonic epithelial tube formation (GO:0001838)4.39456221
51activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)4.39346941
52regulation of dopamine uptake involved in synaptic transmission (GO:0051584)4.38013981
53regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)4.38013981
54apoptotic process involved in morphogenesis (GO:0060561)4.31825525
55detection of temperature stimulus involved in sensory perception of pain (GO:0050965)4.30442226
56detection of temperature stimulus involved in sensory perception (GO:0050961)4.30442226
57ganglion development (GO:0061548)4.30321319
58mating behavior (GO:0007617)4.26688572
59fat-soluble vitamin catabolic process (GO:0042363)4.21500581
60vitamin catabolic process (GO:0009111)4.21500581
61skeletal muscle organ development (GO:0060538)4.20576567
62negative regulation of cardiac muscle cell apoptotic process (GO:0010667)4.19776033
63epithelial tube formation (GO:0072175)4.18203412
64regulation of respiratory gaseous exchange (GO:0043576)4.14814523
65enteric nervous system development (GO:0048484)4.12364798
66coronary vasculature morphogenesis (GO:0060977)4.12035477
67response to insecticide (GO:0017085)4.10686535
68positive regulation of cell adhesion mediated by integrin (GO:0033630)4.10244538
69glucocorticoid biosynthetic process (GO:0006704)4.03304187
70retinoic acid metabolic process (GO:0042573)3.96444594
71cellular response to cadmium ion (GO:0071276)3.95611076
72estrogen biosynthetic process (GO:0006703)3.92223873
73trophoblast giant cell differentiation (GO:0060707)3.90521880
74detection of temperature stimulus (GO:0016048)3.90311264
75positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.89279147
76neurotransmitter metabolic process (GO:0042133)3.86807660
77mechanosensory behavior (GO:0007638)3.84678683
78response to inactivity (GO:0014854)3.74843559
79positive regulation of megakaryocyte differentiation (GO:0045654)3.74840970
80regulation of vesicle fusion (GO:0031338)3.73060022
81negative regulation of striated muscle cell apoptotic process (GO:0010664)3.71065138
82response to corticosterone (GO:0051412)3.68810622
83glucocorticoid metabolic process (GO:0008211)3.65942020
84anatomical structure maturation (GO:0071695)3.65074332
85positive regulation of vesicle fusion (GO:0031340)3.58658737
86axon extension involved in axon guidance (GO:0048846)3.55085146
87neuron projection extension involved in neuron projection guidance (GO:1902284)3.55085146
88negative regulation of macrophage differentiation (GO:0045650)3.54233974
89neurotransmitter secretion (GO:0007269)3.54054482
90neural crest cell development (GO:0014032)3.53892956
91positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)3.51759963
92positive regulation of cell cycle G2/M phase transition (GO:1902751)3.51759963
93* response to pain (GO:0048265)3.48281910
94regulation of oxidative phosphorylation (GO:0002082)3.45606095
95regulation of neurotransmitter transport (GO:0051588)3.42657862
96positive regulation of potassium ion transmembrane transport (GO:1901381)3.42319109
97cellular response to epinephrine stimulus (GO:0071872)3.37806801
98C21-steroid hormone metabolic process (GO:0008207)3.37447573
99embryonic heart tube development (GO:0035050)3.36385514
100regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.29760936
101regulation of circadian sleep/wake cycle (GO:0042749)3.27723152
102regulation of circadian sleep/wake cycle, sleep (GO:0045187)3.27723152
103neurotransmitter transport (GO:0006836)3.26923957
104ear development (GO:0043583)3.26884465
105nerve growth factor signaling pathway (GO:0038180)3.26299766
106nucleobase catabolic process (GO:0046113)3.25785343
107positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)3.25205717
108response to auditory stimulus (GO:0010996)3.21469378
109positive regulation of neurotransmitter transport (GO:0051590)3.19872136
110regulation of neurotransmitter secretion (GO:0046928)3.19237774
111regulation of synaptic transmission, dopaminergic (GO:0032225)3.18315544
112regulation of transcription regulatory region DNA binding (GO:2000677)3.16950447
113neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.16301145
114parturition (GO:0007567)3.15801504
115outflow tract septum morphogenesis (GO:0003148)3.15607109
116adult feeding behavior (GO:0008343)3.15279282
117positive regulation of myotube differentiation (GO:0010831)3.15240475
118regulation of neurotransmitter uptake (GO:0051580)3.12237447
119positive regulation of protein depolymerization (GO:1901881)3.10863394
120G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.10650747
121positive regulation of transcription regulatory region DNA binding (GO:2000679)3.08786467
122regulation of cell size (GO:0008361)3.07368700
123mesenchymal cell development (GO:0014031)3.05709429
124primary amino compound metabolic process (GO:1901160)3.05663445
125response to mineralocorticoid (GO:0051385)3.05432756
126spinal cord motor neuron differentiation (GO:0021522)3.04150534
127* multicellular organismal response to stress (GO:0033555)3.03440314
128tyrosine metabolic process (GO:0006570)3.01721226
129dopamine transport (GO:0015872)3.00069881
130negative regulation of dendrite morphogenesis (GO:0050774)2.98592941
131positive regulation of skeletal muscle tissue development (GO:0048643)2.98482212
132cardiac chamber formation (GO:0003207)2.96612441
133androgen biosynthetic process (GO:0006702)2.95725354
134vitamin transmembrane transport (GO:0035461)2.95279576
135alanine transport (GO:0032328)2.94931016
136heart morphogenesis (GO:0003007)2.93872298
137cellular copper ion homeostasis (GO:0006878)2.90371158
138negative regulation of cell cycle arrest (GO:0071157)2.89670323
139regulation of chemokine-mediated signaling pathway (GO:0070099)2.88881080
140cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.88502357
141* phenol-containing compound biosynthetic process (GO:0046189)2.87883196
142regulation of pigment cell differentiation (GO:0050932)2.86753293
143positive regulation of developmental pigmentation (GO:0048087)2.85808804
144* behavioral response to ethanol (GO:0048149)2.85806620
145regulation of neurotransmitter levels (GO:0001505)2.84492674
146regulation of striated muscle cell apoptotic process (GO:0010662)2.82639811
147gas transport (GO:0015669)2.82407886
148peptidyl-cysteine modification (GO:0018198)2.79875978
149negative regulation of muscle cell apoptotic process (GO:0010656)2.79701047
150glycine transport (GO:0015816)2.78787721
151regulation of respiratory system process (GO:0044065)2.77814926
152phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.77528596
153regulation of cardiac muscle cell apoptotic process (GO:0010665)2.75676673
154developmental programmed cell death (GO:0010623)2.73226687
155cell differentiation in hindbrain (GO:0021533)2.72328928
156eyelid development in camera-type eye (GO:0061029)2.70833068
157regulation of microtubule polymerization (GO:0031113)2.68397876
158positive regulation of catecholamine secretion (GO:0033605)2.66756319
159peristalsis (GO:0030432)2.66476064
160substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.66373317
161substrate-independent telencephalic tangential migration (GO:0021826)2.66373317
162cellular response to zinc ion (GO:0071294)2.65317656
163negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.64893998
164regulation of short-term neuronal synaptic plasticity (GO:0048172)2.64767374
165positive regulation of microtubule polymerization or depolymerization (GO:0031112)2.64656432
166mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.64607770
167synaptic vesicle exocytosis (GO:0016079)2.64090415
168urogenital system development (GO:0001655)2.63826702
169behavioral response to nicotine (GO:0035095)13.6467040
170* phenol-containing compound catabolic process (GO:0019336)11.7439064
171sympathetic nervous system development (GO:0048485)11.4401001
172cartilage morphogenesis (GO:0060536)10.6908588
173cardiac ventricle formation (GO:0003211)10.3615756
174neurotransmitter catabolic process (GO:0042135)10.0010180

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse9.57732594
2E2F7_22180533_ChIP-Seq_HELA_Human4.82244430
3EZH2_22144423_ChIP-Seq_EOC_Human4.38151209
4NR3C1_23031785_ChIP-Seq_PC12_Mouse4.29196753
5ZNF263_19887448_ChIP-Seq_K562_Human3.34875449
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.88624796
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.62346253
8MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.52553582
9SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.43766785
10TAF15_26573619_Chip-Seq_HEK293_Human2.43043596
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.41646072
12FOXM1_23109430_ChIP-Seq_U2OS_Human2.37796362
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.35652767
14ESR1_15608294_ChIP-ChIP_MCF-7_Human2.34144340
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.31140688
16TP63_19390658_ChIP-ChIP_HaCaT_Human2.30313064
17WT1_19549856_ChIP-ChIP_CCG9911_Human2.29165523
18RNF2_18974828_ChIP-Seq_MESCs_Mouse2.26651764
19EZH2_18974828_ChIP-Seq_MESCs_Mouse2.26651764
20SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.25367748
21PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.25082137
22CDX2_19796622_ChIP-Seq_MESCs_Mouse2.24380242
23IKZF1_21737484_ChIP-ChIP_HCT116_Human2.16066911
24MTF2_20144788_ChIP-Seq_MESCs_Mouse2.13729112
25EZH2_27304074_Chip-Seq_ESCs_Mouse2.12221277
26TRIM28_21343339_ChIP-Seq_HEK293_Human2.10114103
27AR_21572438_ChIP-Seq_LNCaP_Human2.07454529
28SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.05095910
29ERG_21242973_ChIP-ChIP_JURKAT_Human2.03229774
30SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.99552211
31BMI1_23680149_ChIP-Seq_NPCS_Mouse1.97528496
32NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.90874778
33ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.90538047
34STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.89821208
35MYC_22102868_ChIP-Seq_BL_Human1.86152273
36JARID2_20064375_ChIP-Seq_MESCs_Mouse1.83266478
37LXR_22292898_ChIP-Seq_THP-1_Human1.82164546
38EP300_21415370_ChIP-Seq_HL-1_Mouse1.74939165
39ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.72397302
40SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.72348932
41BCAT_22108803_ChIP-Seq_LS180_Human1.68837640
42CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.68136436
43MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.67695694
44ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.65807398
45RING1B_27294783_Chip-Seq_NPCs_Mouse1.63386537
46* REST_18959480_ChIP-ChIP_MESCs_Mouse1.61957204
47* REST_21632747_ChIP-Seq_MESCs_Mouse1.61928924
48SRY_22984422_ChIP-ChIP_TESTIS_Rat1.57649628
49ELK3_25401928_ChIP-Seq_HUVEC_Human1.55114432
50CLOCK_20551151_ChIP-Seq_293T_Human1.50879253
51SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.50632431
52EED_16625203_ChIP-ChIP_MESCs_Mouse1.48049432
53RNF2_27304074_Chip-Seq_NSC_Mouse1.43173988
54TCF7_22412390_ChIP-Seq_EML_Mouse1.41794406
55PIAS1_25552417_ChIP-Seq_VCAP_Human1.38303126
56RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.33610751
57AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.30525739
58AR_21909140_ChIP-Seq_LNCAP_Human1.30364922
59CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.28764554
60CTBP1_25329375_ChIP-Seq_LNCAP_Human1.27926196
61KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.27777232
62PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.26879115
63EZH2_27294783_Chip-Seq_ESCs_Mouse1.26631345
64TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.26537866
65KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.26296971
66ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.23768514
67SMAD_19615063_ChIP-ChIP_OVARY_Human1.22522885
68SUZ12_27294783_Chip-Seq_ESCs_Mouse1.22510343
69DROSHA_22980978_ChIP-Seq_HELA_Human1.22383508
70CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.21220610
71* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.20183311
72TOP2B_26459242_ChIP-Seq_MCF-7_Human1.19045189
73PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.18872688
74CBX2_27304074_Chip-Seq_ESCs_Mouse1.18154030
75ESR2_21235772_ChIP-Seq_MCF-7_Human1.18043405
76GBX2_23144817_ChIP-Seq_PC3_Human1.16879576
77PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.15805833
78ZFP281_27345836_Chip-Seq_ESCs_Mouse1.15727162
79MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.14779945
80FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.14757658
81AR_25329375_ChIP-Seq_VCAP_Human1.14628390
82ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.14193338
83SCL_19346495_ChIP-Seq_HPC-7_Human1.13822366
84CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.12468264
85ETV2_25802403_ChIP-Seq_MESCs_Mouse1.09473201
86RING1B_27294783_Chip-Seq_ESCs_Mouse1.09410447
87CTBP2_25329375_ChIP-Seq_LNCAP_Human1.09082860
88E2F4_17652178_ChIP-ChIP_JURKAT_Human1.08975015
89RUNX1_26923725_Chip-Seq_HPCs_Mouse1.08832056
90SMAD4_21799915_ChIP-Seq_A2780_Human1.07198682
91DNAJC2_21179169_ChIP-ChIP_NT2_Human1.05693724
92TP53_20018659_ChIP-ChIP_R1E_Mouse1.05392709
93SA1_27219007_Chip-Seq_ERYTHROID_Human1.05244921
94CTCF_27219007_Chip-Seq_Bcells_Human1.04712541
95CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.04464470
96THAP11_20581084_ChIP-Seq_MESCs_Mouse1.03712846
97VDR_21846776_ChIP-Seq_THP-1_Human1.03434871
98ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02294753
99P300_19829295_ChIP-Seq_ESCs_Human1.02227638
100* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.02061003
101KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.01965884
102POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.00674329
103NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.00616660
104CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.99917645
105TET1_21451524_ChIP-Seq_MESCs_Mouse0.98337452
106WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.97897809
107KDM2B_26808549_Chip-Seq_DND41_Human0.96519462
108KDM2B_26808549_Chip-Seq_SUP-B15_Human0.96438234
109THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.95589380
110TTF2_22483619_ChIP-Seq_HELA_Human0.94975123
111ZFP281_18757296_ChIP-ChIP_E14_Mouse0.94682120
112DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.94553812
113CTCF_27219007_Chip-Seq_ERYTHROID_Human0.94055105
114SMAD4_21741376_ChIP-Seq_HESCs_Human0.93841854
115SOX2_21211035_ChIP-Seq_LN229_Gbm0.93422484
116ESR1_21235772_ChIP-Seq_MCF-7_Human0.93301741
117RARB_27405468_Chip-Seq_BRAIN_Mouse0.93044713
118NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.92919284
119GATA1_19941827_ChIP-Seq_MEL86_Mouse0.92291750
120FOXO3_23340844_ChIP-Seq_DLD1_Human0.92275882
121TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.92152582
122EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.92147692
123POU5F1_16518401_ChIP-PET_MESCs_Mouse0.91707198
124FUS_26573619_Chip-Seq_HEK293_Human0.91332390
125JUN_21703547_ChIP-Seq_K562_Human0.90625180
126CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.90345639
127CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.90260909
128ZFP57_27257070_Chip-Seq_ESCs_Mouse0.89760175
129OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89752881
130STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.89580054
131WT1_25993318_ChIP-Seq_PODOCYTE_Human0.89514328
132MYC_18555785_ChIP-Seq_MESCs_Mouse0.89079759
133RNF2_27304074_Chip-Seq_ESCs_Mouse0.87212419
134BP1_19119308_ChIP-ChIP_Hs578T_Human0.86892945
135EOMES_21245162_ChIP-Seq_HESCs_Human0.85575190
136OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.85191511
137ZNF217_24962896_ChIP-Seq_MCF-7_Human0.82633082
138TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.82415383
139CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.81826156
140GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81398374
141KDM2B_26808549_Chip-Seq_K562_Human0.80124282
142PPARD_21283829_ChIP-Seq_MYOFIBROBLAST_Human0.80039972
143RARG_19884340_ChIP-ChIP_MEFs_Mouse0.78752669
144EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.78451541
145ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.78413593
146SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.78186552
147YAP1_20516196_ChIP-Seq_MESCs_Mouse0.77495134
148EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.77237966
149SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.76619280
150SMAD3_21741376_ChIP-Seq_EPCs_Human0.76411111
151* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.76308289
152PRDM14_20953172_ChIP-Seq_ESCs_Human0.76093620
153CDX2_20551321_ChIP-Seq_CACO-2_Human0.75599680
154SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.75467575
155TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.75265633
156KLF5_20875108_ChIP-Seq_MESCs_Mouse0.74697148

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010386_abnormal_urinary_bladder7.79148992
2MP0002638_abnormal_pupillary_reflex6.89118587
3MP0002009_preneoplasia6.07697839
4MP0004264_abnormal_extraembryonic_tissu4.49095324
5MP0000538_abnormal_urinary_bladder4.18496937
6MP0001529_abnormal_vocalization3.73270661
7MP0004270_analgesia3.67158780
8MP0003868_abnormal_feces_composition3.66816808
9MP0006276_abnormal_autonomic_nervous3.29402960
10MP0002751_abnormal_autonomic_nervous3.19636878
11MP0008872_abnormal_physiological_respon3.16581688
12MP0004858_abnormal_nervous_system3.12061474
13MP0000372_irregular_coat_pigmentation3.08578087
14* MP0001905_abnormal_dopamine_level2.87608855
15MP0002733_abnormal_thermal_nociception2.73800829
16MP0000534_abnormal_ureter_morphology2.61867486
17MP0002909_abnormal_adrenal_gland2.43033544
18MP0001501_abnormal_sleep_pattern2.28993694
19* MP0009745_abnormal_behavioral_response2.27121616
20* MP0001970_abnormal_pain_threshold2.14031526
21MP0009379_abnormal_foot_pigmentation2.08073473
22MP0002127_abnormal_cardiovascular_syste1.97791540
23MP0001756_abnormal_urination1.95532992
24MP0005197_abnormal_uvea_morphology1.95282048
25MP0003279_aneurysm1.92846132
26MP0003635_abnormal_synaptic_transmissio1.90769084
27MP0001664_abnormal_digestion1.90338982
28MP0002064_seizures1.76001519
29MP0000639_abnormal_adrenal_gland1.74390236
30MP0005408_hypopigmentation1.70403508
31MP0003656_abnormal_erythrocyte_physiolo1.69749752
32MP0002166_altered_tumor_susceptibility1.69487567
33MP0002837_dystrophic_cardiac_calcinosis1.68918531
34* MP0002822_catalepsy1.66456074
35* MP0001440_abnormal_grooming_behavior1.63558590
36MP0004859_abnormal_synaptic_plasticity1.61197408
37* MP0002734_abnormal_mechanical_nocicepti1.55769897
38MP0000681_abnormal_thyroid_gland1.51589989
39* MP0002572_abnormal_emotion/affect_behav1.49231908
40MP0002163_abnormal_gland_morphology1.45349289
41MP0003866_abnormal_defecation1.45111594
42* MP0005386_behavior/neurological_phenoty1.40449976
43* MP0004924_abnormal_behavior1.40449976
44MP0002272_abnormal_nervous_system1.40262550
45MP0002160_abnormal_reproductive_system1.38132148
46MP0003638_abnormal_response/metabolism_1.34044860
47MP0005367_renal/urinary_system_phenotyp1.33610708
48MP0000516_abnormal_urinary_system1.33610708
49MP0005085_abnormal_gallbladder_physiolo1.33525604
50MP0000751_myopathy1.31564845
51MP0002184_abnormal_innervation1.30274062
52MP0003937_abnormal_limbs/digits/tail_de1.29008326
53MP0005535_abnormal_body_temperature1.27981053
54MP0000613_abnormal_salivary_gland1.23104605
55MP0008874_decreased_physiological_sensi1.23018705
56MP0003115_abnormal_respiratory_system1.15803497
57MP0002735_abnormal_chemical_nociception1.15512759
58MP0004085_abnormal_heartbeat1.08820601
59MP0005646_abnormal_pituitary_gland1.08214149
60* MP0002063_abnormal_learning/memory/cond1.07817294
61MP0002006_tumorigenesis1.06085177
62MP0009053_abnormal_anal_canal0.99527070
63MP0002090_abnormal_vision0.98805948
64MP0003942_abnormal_urinary_system0.98134171
65MP0000955_abnormal_spinal_cord0.97345818
66MP0000747_muscle_weakness0.96278982
67MP0008932_abnormal_embryonic_tissue0.94912225
68* MP0003633_abnormal_nervous_system0.93809700
69* MP0003631_nervous_system_phenotype0.91964193
70MP0004883_abnormal_blood_vessel0.88852333
71MP0005409_darkened_coat_color0.88360785
72* MP0003953_abnormal_hormone_level0.88076906
73MP0002067_abnormal_sensory_capabilities0.87578613
74MP0000778_abnormal_nervous_system0.87565363
75MP0005379_endocrine/exocrine_gland_phen0.87494105
76MP0000013_abnormal_adipose_tissue0.87190610
77MP0002139_abnormal_hepatobiliary_system0.86660218
78MP0000428_abnormal_craniofacial_morphol0.86646715
79MP0003122_maternal_imprinting0.85523094
80MP0002269_muscular_atrophy0.84263558
81MP0002557_abnormal_social/conspecific_i0.83251676
82MP0006138_congestive_heart_failure0.83103150
83MP0003567_abnormal_fetal_cardiomyocyte0.82760754
84MP0004811_abnormal_neuron_physiology0.82571549
85MP0005083_abnormal_biliary_tract0.82124995
86MP0004272_abnormal_basement_membrane0.82053116
87MP0000749_muscle_degeneration0.81790465
88MP0001270_distended_abdomen0.81407038
89MP0003329_amyloid_beta_deposits0.81024417
90MP0005503_abnormal_tendon_morphology0.77138469
91MP0000230_abnormal_systemic_arterial0.76395464
92MP0001730_embryonic_growth_arrest0.76112010
93MP0008438_abnormal_cutaneous_collagen0.75137240
94* MP0002066_abnormal_motor_capabilities/c0.74065335
95MP0003077_abnormal_cell_cycle0.73328661
96MP0001968_abnormal_touch/_nociception0.72203566
97MP0003632_abnormal_nervous_system0.71335797
98MP0005171_absent_coat_pigmentation0.69985214
99MP0002882_abnormal_neuron_morphology0.69267677
100MP0010094_abnormal_chromosome_stability0.68796040
101MP0008260_abnormal_autophagy0.67536191
102MP0001348_abnormal_lacrimal_gland0.63357593
103MP0009046_muscle_twitch0.61033086
104MP0002084_abnormal_developmental_patter0.59759809
105* MP0002069_abnormal_eating/drinking_beha0.59557403
106MP0005499_abnormal_olfactory_system0.59327634
107MP0005394_taste/olfaction_phenotype0.59327634
108MP0002332_abnormal_exercise_endurance0.59035436
109MP0005636_abnormal_mineral_homeostasis0.57821709
110MP0001188_hyperpigmentation0.57373172
111MP0002109_abnormal_limb_morphology0.57271006
112MP0000759_abnormal_skeletal_muscle0.57171775
113MP0005275_abnormal_skin_tensile0.56945008
114MP0003861_abnormal_nervous_system0.56349303
115MP0005670_abnormal_white_adipose0.56177640
116MP0009697_abnormal_copulation0.56029309
117MP0005187_abnormal_penis_morphology0.55945238
118MP0002085_abnormal_embryonic_tissue0.53829610
119MP0000477_abnormal_intestine_morphology0.53770704
120MP0001765_abnormal_ion_homeostasis0.51086937
121MP0004036_abnormal_muscle_relaxation0.50881087
122MP0002752_abnormal_somatic_nervous0.50423904
123MP0008873_increased_physiological_sensi0.49793289
124MP0003948_abnormal_gas_homeostasis0.49691552
125* MP0001340_abnormal_eyelid_morphology0.49069660
126MP0005620_abnormal_muscle_contractility0.48760209
127* MP0010770_preweaning_lethality0.48559763
128* MP0002082_postnatal_lethality0.48559763
129* MP0001731_abnormal_postnatal_growth0.48506933
130MP0000049_abnormal_middle_ear0.48427668
131MP0001666_abnormal_nutrient_absorption0.48424515
132* MP0002152_abnormal_brain_morphology0.48328893
133MP0008770_decreased_survivor_rate0.48230936
134MP0005623_abnormal_meninges_morphology0.48186114
135MP0000631_abnormal_neuroendocrine_gland0.47702247
136MP0002106_abnormal_muscle_physiology0.47461195
137MP0002697_abnormal_eye_size0.47213840
138MP0008789_abnormal_olfactory_epithelium0.46918615
139MP0000350_abnormal_cell_proliferation0.46911936
140MP0005389_reproductive_system_phenotype0.46830390
141MP0000762_abnormal_tongue_morphology0.45544234
142* MP0010769_abnormal_survival0.45139276
143* MP0010768_mortality/aging0.43347600
144MP0005423_abnormal_somatic_nervous0.43346110
145MP0003705_abnormal_hypodermis_morpholog0.41108297
146MP0008057_abnormal_DNA_replication0.40993606
147MP0005369_muscle_phenotype0.40488664
148MP0009333_abnormal_splenocyte_physiolog0.40276330
149MP0003283_abnormal_digestive_organ0.39466004
150MP0005380_embryogenesis_phenotype0.39229287
151MP0001672_abnormal_embryogenesis/_devel0.39229287
152MP0005076_abnormal_cell_differentiation0.38964962
153MP0003111_abnormal_nucleus_morphology0.38855432
154MP0003984_embryonic_growth_retardation0.37875919
155MP0005584_abnormal_enzyme/coenzyme_acti0.37717506
156MP0004130_abnormal_muscle_cell0.36953322
157MP0002088_abnormal_embryonic_growth/wei0.35789056

Predicted human phenotypes

RankGene SetZ-score
1* Hypothermia (HP:0002045)9.00159905
2Abnormality of the parathyroid morphology (HP:0011766)7.81863209
3Facial shape deformation (HP:0011334)7.67903170
4Potter facies (HP:0002009)7.67903170
5* Abnormal autonomic nervous system physiology (HP:0012332)7.52247178
6Myokymia (HP:0002411)7.44364283
7Failure to thrive in infancy (HP:0001531)7.14036563
8* Orthostatic hypotension (HP:0001278)7.01265545
9Bicornuate uterus (HP:0000813)5.75759956
10Amblyopia (HP:0000646)5.63792972
11Limb dystonia (HP:0002451)5.25491494
12Cerebral hemorrhage (HP:0001342)5.24289036
13Exotropia (HP:0000577)5.19245673
14Neoplasm of the peripheral nervous system (HP:0100007)4.82482654
15Autoamputation (HP:0001218)4.80073636
16Impulsivity (HP:0100710)4.78816577
17Bowel diverticulosis (HP:0005222)4.65614918
18Hyperparathyroidism (HP:0000843)4.50711409
19Neonatal onset (HP:0003623)4.41751899
20Renal dysplasia (HP:0000110)4.41687195
21Myotonia (HP:0002486)4.23194411
22Disproportionate tall stature (HP:0001519)4.19003845
23Abnormality of aromatic amino acid family metabolism (HP:0004338)4.00153539
24Arthropathy (HP:0003040)3.92514990
25Episodic fever (HP:0001954)3.80447761
26Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.78908503
27Aplastic anemia (HP:0001915)3.66654939
28Hypoventilation (HP:0002791)3.53408470
29Asymmetry of the thorax (HP:0001555)3.49899085
30Impaired pain sensation (HP:0007328)3.48035422
31Abnormality of pain sensation (HP:0010832)3.48035422
32Nervous tissue neoplasm (HP:0030060)3.38632667
33Neuroectodermal neoplasm (HP:0030061)3.38632667
34Neuroepithelial neoplasm (HP:0030063)3.38632667
35External ophthalmoplegia (HP:0000544)3.29594359
36Malignant neoplasm of the central nervous system (HP:0100836)3.21431104
37* Hypotension (HP:0002615)3.20119366
38Occipital encephalocele (HP:0002085)3.18879728
39Action tremor (HP:0002345)3.14980115
40Hyperthyroidism (HP:0000836)3.14734862
41Hypercalcemia (HP:0003072)3.13037370
42Abnormality of the phalanges of the hallux (HP:0010057)3.11902464
43Enlarged penis (HP:0000040)2.99624356
44Renal salt wasting (HP:0000127)2.99620824
45Pheochromocytoma (HP:0002666)2.98994083
46Annular pancreas (HP:0001734)2.89163674
47Recurrent corneal erosions (HP:0000495)2.88895822
48Ectopic kidney (HP:0000086)2.85832875
49Dysautonomia (HP:0002459)2.85480332
50Abnormality of the aortic arch (HP:0012303)2.81838662
51Abnormal pupillary function (HP:0007686)2.81046605
52Atonic seizures (HP:0010819)2.78653366
53Adducted thumb (HP:0001181)2.77130667
54Intestinal polyposis (HP:0200008)2.74146584
55Abnormality of the epiphysis of the femoral head (HP:0010574)2.73423582
56Glossoptosis (HP:0000162)2.71392876
57Focal seizures (HP:0007359)2.71162094
58Neuroendocrine neoplasm (HP:0100634)2.70989643
59Sensory axonal neuropathy (HP:0003390)2.70887913
60Postural tremor (HP:0002174)2.69861601
61Synostosis involving the elbow (HP:0003938)2.63029999
62Humeroradial synostosis (HP:0003041)2.63029999
63Thyroid carcinoma (HP:0002890)2.62769240
64Intestinal polyp (HP:0005266)2.59128074
65Agitation (HP:0000713)2.58834173
66Oligodactyly (HP:0012165)2.58538758
67Goiter (HP:0000853)2.55741390
68Abnormality of the 4th metacarpal (HP:0010012)2.55732246
69Vaginal atresia (HP:0000148)2.54449860
70Focal motor seizures (HP:0011153)2.53444347
71Progressive cerebellar ataxia (HP:0002073)2.52564727
72Abnormality of the femoral head (HP:0003368)2.47392871
73Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.45731854
74Abnormality of femoral epiphyses (HP:0006499)2.45731854
75Non-midline cleft lip (HP:0100335)2.43518970
76Genital tract atresia (HP:0001827)2.40563223
77Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.38982345
78Renal agenesis (HP:0000104)2.36759771
79Anhidrosis (HP:0000970)2.36449789
80Generalized tonic-clonic seizures (HP:0002069)2.36385878
81Limb hypertonia (HP:0002509)2.35317927
82Decreased circulating renin level (HP:0003351)2.33781154
83Metaphyseal dysplasia (HP:0100255)2.33566447
84Papilledema (HP:0001085)2.33297975
85Neuroblastoma (HP:0003006)2.32767359
86Primitive neuroectodermal tumor (HP:0030065)2.32767359
87Neuroblastic tumors (HP:0004376)2.32767359
88Peripheral primitive neuroectodermal neoplasm (HP:0030067)2.32767359
89Insidious onset (HP:0003587)2.31326216
90Termporal pattern (HP:0011008)2.31326216
91Acute necrotizing encephalopathy (HP:0006965)2.30122776
92Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.30035713
93Bradycardia (HP:0001662)2.29267750
94Emotional lability (HP:0000712)2.26536641
95Abnormal pancreas size (HP:0012094)2.25490069
96Wrist flexion contracture (HP:0001239)2.22063665
97Broad distal phalanx of finger (HP:0009836)2.22041997
98Increased circulating renin level (HP:0000848)2.19926460
99Increased hepatocellular lipid droplets (HP:0006565)2.19003912
100Abnormality of the corticospinal tract (HP:0002492)2.16405352
101Short middle phalanx of the 5th finger (HP:0004220)2.15488143
102Mitochondrial inheritance (HP:0001427)2.12698385
103Hyporeflexia of lower limbs (HP:0002600)2.11515325
104Bilateral microphthalmos (HP:0007633)2.08397420
105Anxiety (HP:0000739)2.07545185
106Short clavicles (HP:0000894)2.06605176
107Increased serum pyruvate (HP:0003542)2.06125145
108Abnormality of glycolysis (HP:0004366)2.06125145
109Axonal loss (HP:0003447)2.05559725
110Microglossia (HP:0000171)2.05553602
111Progressive macrocephaly (HP:0004481)2.05212095
112Abnormality of renin-angiotensin system (HP:0000847)2.04386012
113Hypercortisolism (HP:0001578)2.04155047
114Abnormal mitochondria in muscle tissue (HP:0008316)2.03819308
115Testicular neoplasm (HP:0010788)2.02658284
116Lipid accumulation in hepatocytes (HP:0006561)2.02525936
117Palpitations (HP:0001962)2.02431132
118Visual hallucinations (HP:0002367)2.01559435
119Hyperacusis (HP:0010780)1.99431226
120Abnormality of dental color (HP:0011073)1.98401316
121Abnormality of the distal phalanx of the thumb (HP:0009617)1.97244009
122Ulnar claw (HP:0001178)1.96315157
123Premature rupture of membranes (HP:0001788)1.96295017
124Absence seizures (HP:0002121)1.94870759
125Redundant skin (HP:0001582)1.94607203
126Self-mutilation (HP:0000742)1.92970392
127Febrile seizures (HP:0002373)1.92078532
128Renal Fanconi syndrome (HP:0001994)1.90274435
129Esophageal atresia (HP:0002032)1.90101476
130Menstrual irregularities (HP:0000858)1.88014912
131Adrenal overactivity (HP:0002717)1.86093523
132Sudden death (HP:0001699)1.82959862
133Cerebral edema (HP:0002181)1.82505480
134Acute encephalopathy (HP:0006846)1.81847150
135Deep venous thrombosis (HP:0002625)1.81355794
136Craniofacial dystonia (HP:0012179)1.81311197
137Hypoplasia of the uterus (HP:0000013)1.80202650
138Syncope (HP:0001279)1.79434694
139Growth hormone excess (HP:0000845)1.79423248
140Abnormal umbilical cord blood vessels (HP:0011403)1.78722763
141Single umbilical artery (HP:0001195)1.78722763
142Abnormality of the fetal cardiovascular system (HP:0010948)1.78722763
143Abnormality of calcium-phosphate metabolism (HP:0100530)1.76716949
144Thick eyebrow (HP:0000574)1.76168766
145Abnormal hemoglobin (HP:0011902)1.76035409
146Aplasia/Hypoplasia of the clavicles (HP:0006710)1.75353603
147Renovascular hypertension (HP:0100817)1.74467831
148Delayed closure of the anterior fontanelle (HP:0001476)1.74451807
149Asymmetric septal hypertrophy (HP:0001670)1.74267823
150Torticollis (HP:0000473)1.73142818
151Rapidly progressive (HP:0003678)1.72584583
152Hypotrichosis (HP:0001006)1.72042913
153Neoplasm of the thyroid gland (HP:0100031)1.71328035
154Truncus arteriosus (HP:0001660)1.70850770
155Joint laxity (HP:0001388)1.69791015
156Delusions (HP:0000746)1.68943609
157Turricephaly (HP:0000262)1.68443347
158Hypokinesia (HP:0002375)1.68302538
159Cutaneous finger syndactyly (HP:0010554)1.68201243
160Hyperaldosteronism (HP:0000859)1.68031998
161Muscle stiffness (HP:0003552)1.67791368
162Aplasia/Hypoplasia of the brainstem (HP:0007362)1.67427810
163Volvulus (HP:0002580)1.63579990
164Oligohydramnios (HP:0001562)1.61945375
165Cafe-au-lait spot (HP:0000957)1.59789223
166Complement deficiency (HP:0004431)1.59061504
167Elfin facies (HP:0004428)1.55330400
168Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.54816482
169Pulmonary hypoplasia (HP:0002089)1.53296023
170Sepsis (HP:0100806)1.52986027
171Obsessive-compulsive behavior (HP:0000722)1.52224359
172Abnormality of the distal phalanges of the toes (HP:0010182)1.51777230
173Short 4th metacarpal (HP:0010044)1.51010965
174Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.51010965
175Tracheoesophageal fistula (HP:0002575)1.47035029
176Cutaneous syndactyly (HP:0012725)1.44987839
177Shawl scrotum (HP:0000049)1.44049180
178Overriding aorta (HP:0002623)1.43666436
179Absent radius (HP:0003974)1.43128156
180Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.40985020
181Radioulnar synostosis (HP:0002974)1.39366089

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK17.72996778
2GRK76.74668636
3MATK4.30457298
4GRK53.82077241
5ICK2.63030242
6MAPKAPK52.39072243
7MAP3K42.24966341
8PNCK2.09745666
9MAP2K12.07080487
10CSNK1G32.05564055
11NTRK32.05160749
12DDR22.01029754
13ADRBK11.96743361
14EIF2AK11.92844220
15AKT31.87635370
16MAP3K101.86573567
17SMG11.86286273
18SCYL21.79688992
19TRIB31.79476611
20TYRO31.74113892
21PRPF4B1.72692373
22CSNK1G21.69081817
23MAP3K121.60737027
24EEF2K1.57016565
25MAP3K21.56623840
26GRK61.49868005
27MAP2K71.46990550
28CDK121.42422472
29LIMK11.41073483
30ARAF1.37460392
31CSNK1G11.37375651
32MINK11.37369114
33NME21.36521368
34MAP2K41.34786281
35ALK1.26952087
36KSR21.25771200
37PRKCE1.24379498
38TSSK61.23983551
39BUB11.19992819
40DAPK21.18141331
41RIPK11.17649683
42UHMK11.16869443
43TESK11.14102645
44INSRR1.08496389
45PASK1.03768115
46WNK11.03191825
47NTRK21.02485114
48CAMKK21.02095893
49PRKD30.98703312
50MYLK0.98548104
51ERBB20.93390585
52FGFR40.92306645
53VRK20.91932502
54TESK20.87270404
55CDC70.86896014
56FGFR20.85774813
57MELK0.83450709
58MARK10.83214181
59LATS20.80579123
60PDGFRB0.79611841
61MAPK40.79566281
62PHKG20.78740343
63PHKG10.78740343
64TAF10.77644082
65RPS6KA20.73636882
66ATR0.73127747
67WNK40.70843105
68MUSK0.70298716
69BRD40.70052421
70LMTK20.70034065
71PTK2B0.69607609
72MTOR0.69603430
73STK390.69257998
74PLK40.65096838
75CDK40.64557469
76CAMK2B0.64456242
77NME10.63027375
78CAMK1D0.62641255
79DAPK10.62130116
80SIK30.61966841
81SRPK10.59194627
82PAK40.58702656
83LRRK20.58053449
84PRKCG0.57366987
85CSNK1A1L0.57309244
86CAMK2G0.56965879
87TRPM70.56251798
88CAMK1G0.56051838
89SGK20.55200831
90CHEK20.54145311
91FLT30.53163210
92CAMK2D0.53120432
93RET0.52522430
94CDK60.52206726
95MAP2K20.52106019
96CDK50.51753379
97DYRK20.50873907
98CDK150.49777959
99CDK180.48956516
100PLK20.48411355
101SGK2230.47546881
102SGK4940.47546881
103MAP3K90.47014653
104CDK70.46766073
105CAMKK10.46249317
106STK40.46224293
107CDK140.46098859
108CSNK1E0.45869084
109DYRK30.45220706
110LYN0.44344657
111CDK30.43648964
112AKT10.43586169
113SGK30.43132777
114CDK11A0.43014301
115MET0.42831522
116FGR0.42385738
117DAPK30.41685283
118STK240.41291847
119CDC42BPA0.41219772
120CHEK10.40313917
121PRKACA0.40234415
122MKNK10.39071678
123CDK20.38595912
124PTK20.38202379
125BMPR1B0.37860756
126MKNK20.37155153
127IGF1R0.36728061
128LCK0.36601812
129CAMK2A0.36462108
130PIM20.35459218
131CAMK40.34333863
132PKN20.33698622
133PDGFRA0.32691762
134MAPK130.31343795
135SIK10.31222929
136PRKACG0.31148831
137TTN0.30940345
138PDK30.30771790
139PDK40.30771790
140ILK0.30311826
141PRKCB0.30036875
142TTK0.29396640
143AURKA0.28650628
144EPHB20.28410981
145MAP3K10.27828798
146CDK10.27745572
147DYRK1B0.27732754
148SRC0.27334309
149PAK30.27091706
150PIK3CA0.26272865
151MAPK80.24926613
152ATM0.24772456
153PRKCH0.24519435
154SIK20.22405389
155ZAP700.21618530
156EPHA30.21586393
157PRKACB0.21495306
158CDK90.21089615
159IRAK30.20354819
160MAPK140.19616575
161MAPK110.19455943
162MAP2K30.19109094
163HCK0.18231827
164FGFR30.17478009
165RPS6KA10.17320706

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine metabolism_Homo sapiens_hsa003605.26610980
2* Tyrosine metabolism_Homo sapiens_hsa003503.85124195
3Histidine metabolism_Homo sapiens_hsa003403.75586881
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.60480340
5Cocaine addiction_Homo sapiens_hsa050303.05304340
6Retinol metabolism_Homo sapiens_hsa008302.53418373
7Cholinergic synapse_Homo sapiens_hsa047252.52634617
8Oxidative phosphorylation_Homo sapiens_hsa001902.49546076
9Parkinsons disease_Homo sapiens_hsa050122.47030852
10Amphetamine addiction_Homo sapiens_hsa050312.42903051
11Tryptophan metabolism_Homo sapiens_hsa003802.35792223
12Caffeine metabolism_Homo sapiens_hsa002322.24558278
13Aldosterone synthesis and secretion_Homo sapiens_hsa049252.23991212
14Dopaminergic synapse_Homo sapiens_hsa047282.19528753
15Synaptic vesicle cycle_Homo sapiens_hsa047212.14001214
16Serotonergic synapse_Homo sapiens_hsa047262.12586265
17Non-small cell lung cancer_Homo sapiens_hsa052232.12238853
18Proteasome_Homo sapiens_hsa030502.09834016
19Complement and coagulation cascades_Homo sapiens_hsa046102.08707255
20DNA replication_Homo sapiens_hsa030301.83077104
21Alzheimers disease_Homo sapiens_hsa050101.79676720
22Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.76154579
23Collecting duct acid secretion_Homo sapiens_hsa049661.73818071
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.65276521
25Renin secretion_Homo sapiens_hsa049241.64285363
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.62197802
27Lysine degradation_Homo sapiens_hsa003101.60445588
28Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.58537042
29Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.55010884
30Ovarian steroidogenesis_Homo sapiens_hsa049131.53841484
31Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.43855609
32Arginine and proline metabolism_Homo sapiens_hsa003301.40495514
33Bile secretion_Homo sapiens_hsa049761.36013461
34Notch signaling pathway_Homo sapiens_hsa043301.34369888
35Huntingtons disease_Homo sapiens_hsa050161.28223258
36Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.26178840
37Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.19605843
38Circadian entrainment_Homo sapiens_hsa047131.17198257
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.16278692
40Drug metabolism - other enzymes_Homo sapiens_hsa009831.15712073
41Glioma_Homo sapiens_hsa052141.13723784
42Long-term depression_Homo sapiens_hsa047301.13595516
43Gap junction_Homo sapiens_hsa045401.12554036
44Colorectal cancer_Homo sapiens_hsa052101.11994975
45Cell cycle_Homo sapiens_hsa041101.11246488
46Olfactory transduction_Homo sapiens_hsa047401.11146448
47GnRH signaling pathway_Homo sapiens_hsa049121.10930785
48Primary bile acid biosynthesis_Homo sapiens_hsa001201.10849717
49Vibrio cholerae infection_Homo sapiens_hsa051101.10147444
50Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.09683978
51Non-homologous end-joining_Homo sapiens_hsa034501.08428365
52African trypanosomiasis_Homo sapiens_hsa051431.06645547
53Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.06609914
54Insulin secretion_Homo sapiens_hsa049111.05923664
55Pancreatic secretion_Homo sapiens_hsa049721.05921641
56Chronic myeloid leukemia_Homo sapiens_hsa052201.05575144
57Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.05281514
58mRNA surveillance pathway_Homo sapiens_hsa030151.04612139
59Salivary secretion_Homo sapiens_hsa049701.01860255
60Steroid hormone biosynthesis_Homo sapiens_hsa001401.00393871
61Spliceosome_Homo sapiens_hsa030400.96088733
62Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.94930754
63Chemical carcinogenesis_Homo sapiens_hsa052040.94329007
64Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.94125613
65Estrogen signaling pathway_Homo sapiens_hsa049150.88617841
66Mismatch repair_Homo sapiens_hsa034300.88042499
67Cysteine and methionine metabolism_Homo sapiens_hsa002700.86924149
68Vascular smooth muscle contraction_Homo sapiens_hsa042700.84612598
69Pyruvate metabolism_Homo sapiens_hsa006200.84479752
70Gastric acid secretion_Homo sapiens_hsa049710.82928832
71One carbon pool by folate_Homo sapiens_hsa006700.82504586
72Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.81620293
73Cardiac muscle contraction_Homo sapiens_hsa042600.81469235
74Alcoholism_Homo sapiens_hsa050340.81247554
75Dorso-ventral axis formation_Homo sapiens_hsa043200.80266765
76Fatty acid metabolism_Homo sapiens_hsa012120.79642075
77Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.79467026
78Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.79318846
79Long-term potentiation_Homo sapiens_hsa047200.78701812
80Glutamatergic synapse_Homo sapiens_hsa047240.78681818
81Fatty acid elongation_Homo sapiens_hsa000620.78529309
82Pentose and glucuronate interconversions_Homo sapiens_hsa000400.78428951
83Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.77820016
84Endometrial cancer_Homo sapiens_hsa052130.76543440
85Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.74742141
86Pancreatic cancer_Homo sapiens_hsa052120.73525871
87Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.70731902
88Folate biosynthesis_Homo sapiens_hsa007900.69733926
89AMPK signaling pathway_Homo sapiens_hsa041520.69388926
90Steroid biosynthesis_Homo sapiens_hsa001000.67292645
91MicroRNAs in cancer_Homo sapiens_hsa052060.67141465
92Oxytocin signaling pathway_Homo sapiens_hsa049210.66861519
93Biosynthesis of amino acids_Homo sapiens_hsa012300.64918208
94VEGF signaling pathway_Homo sapiens_hsa043700.64113209
95Ribosome_Homo sapiens_hsa030100.63460653
96Phagosome_Homo sapiens_hsa041450.63452687
97Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.62781627
98RNA transport_Homo sapiens_hsa030130.62673161
99Taste transduction_Homo sapiens_hsa047420.61793678
100Butanoate metabolism_Homo sapiens_hsa006500.60938900
101Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.60736003
102ErbB signaling pathway_Homo sapiens_hsa040120.59607528
103Propanoate metabolism_Homo sapiens_hsa006400.57888799
104Thyroid hormone synthesis_Homo sapiens_hsa049180.57593280
105Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.57336398
106Thyroid cancer_Homo sapiens_hsa052160.56233359
107Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55952322
108Prion diseases_Homo sapiens_hsa050200.55052779
109mTOR signaling pathway_Homo sapiens_hsa041500.54770900
110Sulfur metabolism_Homo sapiens_hsa009200.53555565
111Fanconi anemia pathway_Homo sapiens_hsa034600.53442740
112Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.52693193
113cAMP signaling pathway_Homo sapiens_hsa040240.51855341
114Glucagon signaling pathway_Homo sapiens_hsa049220.51706498
115cGMP-PKG signaling pathway_Homo sapiens_hsa040220.51635430
116Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51506144
117Prolactin signaling pathway_Homo sapiens_hsa049170.51246346
118Sphingolipid signaling pathway_Homo sapiens_hsa040710.48735615
119Fatty acid degradation_Homo sapiens_hsa000710.48207661
120Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.48118612
121Calcium signaling pathway_Homo sapiens_hsa040200.47693960
122Glycerolipid metabolism_Homo sapiens_hsa005610.47562604
123alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.47098588
124Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46354672
125Base excision repair_Homo sapiens_hsa034100.43709014
126Renal cell carcinoma_Homo sapiens_hsa052110.42443845
127Prostate cancer_Homo sapiens_hsa052150.41296087
128Sulfur relay system_Homo sapiens_hsa041220.40580793
129Melanogenesis_Homo sapiens_hsa049160.40323049
130Rap1 signaling pathway_Homo sapiens_hsa040150.39905438
131Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.37639818
132Bladder cancer_Homo sapiens_hsa052190.37262128
133Adipocytokine signaling pathway_Homo sapiens_hsa049200.36965505
134Pyrimidine metabolism_Homo sapiens_hsa002400.36457202
135Phospholipase D signaling pathway_Homo sapiens_hsa040720.36318787
136Pathways in cancer_Homo sapiens_hsa052000.35501972
137GABAergic synapse_Homo sapiens_hsa047270.35240212
138Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.34647612
139Rheumatoid arthritis_Homo sapiens_hsa053230.33593301
140AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.30878702
141Morphine addiction_Homo sapiens_hsa050320.30531298
142Nicotine addiction_Homo sapiens_hsa050330.30337113
143Arginine biosynthesis_Homo sapiens_hsa002200.29658383
144Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.29638124
145Glycerophospholipid metabolism_Homo sapiens_hsa005640.29498320
146Linoleic acid metabolism_Homo sapiens_hsa005910.29438782
147Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.28941257
148Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.28741427
149Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.28148343
150Neurotrophin signaling pathway_Homo sapiens_hsa047220.27695603
151Dilated cardiomyopathy_Homo sapiens_hsa054140.25740004
152Carbon metabolism_Homo sapiens_hsa012000.25668286
153Insulin signaling pathway_Homo sapiens_hsa049100.23971380
154Amoebiasis_Homo sapiens_hsa051460.23273136
155PPAR signaling pathway_Homo sapiens_hsa033200.22579741
156Central carbon metabolism in cancer_Homo sapiens_hsa052300.21902096
157Axon guidance_Homo sapiens_hsa043600.21589537
158Fructose and mannose metabolism_Homo sapiens_hsa000510.21551192
159Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.21286335
160Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.20430005

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