DBI

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes diazepam binding inhibitor, a protein that is regulated by hormones and is involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines, which modulate signal transduction at type A gamma-aminobutyric acid receptors located in brain synapses. The protein is conserved from yeast to mammals, with the most highly conserved domain consisting of seven contiguous residues that constitute the hydrophobic binding site for medium- and long-chain acyl-Coenzyme A esters. Diazepam binding inhibitor is also known to mediate the feedback regulation of pancreatic secretion and the postprandial release of cholecystokinin, in addition to its role as a mediator in corticotropin-dependent adrenal steroidogenesis. Three pseudogenes located on chromosomes 6, 8 and 16 have been identified. Multiple transcript variants encoding different isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium movement (GO:0003341)8.00651639
2axoneme assembly (GO:0035082)7.82459022
3axonemal dynein complex assembly (GO:0070286)6.23831539
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.58172935
5central nervous system myelination (GO:0022010)5.24089266
6axon ensheathment in central nervous system (GO:0032291)5.24089266
7cilium or flagellum-dependent cell motility (GO:0001539)5.07676706
8epithelial cilium movement (GO:0003351)4.76724773
9ventricular system development (GO:0021591)4.76623966
10mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.66895174
11respiratory electron transport chain (GO:0022904)4.47942525
12energy coupled proton transport, down electrochemical gradient (GO:0015985)4.47760267
13ATP synthesis coupled proton transport (GO:0015986)4.47760267
14GTP biosynthetic process (GO:0006183)4.40807819
15electron transport chain (GO:0022900)4.35440034
16left/right axis specification (GO:0070986)4.35314455
17erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.30882709
18L-phenylalanine catabolic process (GO:0006559)4.30882709
19alpha-linolenic acid metabolic process (GO:0036109)4.26775865
20triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.07850004
21UTP metabolic process (GO:0046051)4.03242453
22establishment of protein localization to mitochondrial membrane (GO:0090151)4.00860984
23erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.98660193
24L-phenylalanine metabolic process (GO:0006558)3.98660193
25regulation of glucose import in response to insulin stimulus (GO:2001273)3.91018378
26regulation of cellular amino acid metabolic process (GO:0006521)3.77369938
27UTP biosynthetic process (GO:0006228)3.75457647
28regulation of triglyceride catabolic process (GO:0010896)3.71691531
29respiratory chain complex IV assembly (GO:0008535)3.70890286
30nucleoside diphosphate phosphorylation (GO:0006165)3.70546208
31low-density lipoprotein particle remodeling (GO:0034374)3.69086669
32negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.68543708
33proteasome assembly (GO:0043248)3.63680459
34regulation of cholesterol esterification (GO:0010872)3.57895026
35cysteine metabolic process (GO:0006534)3.57649930
36cholesterol biosynthetic process (GO:0006695)3.57035389
37regulation of macrophage chemotaxis (GO:0010758)3.56661192
38tricarboxylic acid cycle (GO:0006099)3.54330392
39very long-chain fatty acid metabolic process (GO:0000038)3.49752879
40positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.49404638
41xenobiotic catabolic process (GO:0042178)3.47666421
42aromatic amino acid family catabolic process (GO:0009074)3.45688872
43sterol biosynthetic process (GO:0016126)3.44027378
44negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.43643838
45negative regulation of ligase activity (GO:0051352)3.43643838
46branched-chain amino acid catabolic process (GO:0009083)3.41727824
47regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.40732200
48cytochrome complex assembly (GO:0017004)3.40477865
49amino-acid betaine metabolic process (GO:0006577)3.40448566
50chaperone-mediated protein transport (GO:0072321)3.40323854
51cellular response to cholesterol (GO:0071397)3.38792915
52C4-dicarboxylate transport (GO:0015740)3.34798964
53cellular ketone body metabolic process (GO:0046950)3.34737093
54DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.33158620
55oxidative phosphorylation (GO:0006119)3.32363924
56regulation of oxidative phosphorylation (GO:0002082)3.30695974
57glyoxylate metabolic process (GO:0046487)3.30022696
58carnitine metabolic process (GO:0009437)3.26127825
59bile acid biosynthetic process (GO:0006699)3.24631428
60cellular response to zinc ion (GO:0071294)3.23541369
61aspartate family amino acid catabolic process (GO:0009068)3.22320400
62signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.22169794
63signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.22169794
64signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.22169794
65intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.21956276
66signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.21956276
67fatty acid homeostasis (GO:0055089)3.21937798
68fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.20752762
69fatty acid elongation (GO:0030497)3.20262619
70oligodendrocyte differentiation (GO:0048709)3.19843842
71cellular response to sterol (GO:0036315)3.17074880
72reverse cholesterol transport (GO:0043691)3.16303605
73aldehyde catabolic process (GO:0046185)3.15750758
74anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.14199595
75plasma lipoprotein particle remodeling (GO:0034369)3.13752794
76protein-lipid complex remodeling (GO:0034368)3.13752794
77macromolecular complex remodeling (GO:0034367)3.13752794
78water-soluble vitamin biosynthetic process (GO:0042364)3.12510359
79thioester biosynthetic process (GO:0035384)3.12407374
80acyl-CoA biosynthetic process (GO:0071616)3.12407374
81short-chain fatty acid metabolic process (GO:0046459)3.12315527
82NADH metabolic process (GO:0006734)3.11023900
83fatty acid beta-oxidation (GO:0006635)3.10815268
84very-low-density lipoprotein particle assembly (GO:0034379)3.10148284
85low-density lipoprotein particle clearance (GO:0034383)3.09555821
86positive regulation of cellular response to insulin stimulus (GO:1900078)3.08832287
87microtubule bundle formation (GO:0001578)3.08692869
88regulation of mononuclear cell migration (GO:0071675)3.08241492
89signal transduction involved in DNA integrity checkpoint (GO:0072401)3.07560074
90signal transduction involved in DNA damage checkpoint (GO:0072422)3.07560074
91sulfur amino acid catabolic process (GO:0000098)3.07488618
92protein heterotetramerization (GO:0051290)3.06478223
93L-serine metabolic process (GO:0006563)3.05984427
94photoreceptor cell differentiation (GO:0046530)3.05304977
95eye photoreceptor cell differentiation (GO:0001754)3.05304977
96epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.01956031
97lipid oxidation (GO:0034440)3.01780403
98plasma lipoprotein particle clearance (GO:0034381)3.01177797
99signal transduction involved in cell cycle checkpoint (GO:0072395)3.00715261
100regulation of cellular amine metabolic process (GO:0033238)2.99841910
101protein complex biogenesis (GO:0070271)2.99231072
102high-density lipoprotein particle remodeling (GO:0034375)2.97708432
103ketone body metabolic process (GO:1902224)2.97164507
104antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.97005981
105fatty acid catabolic process (GO:0009062)2.94744255
106thioester metabolic process (GO:0035383)2.93780560
107fatty acid oxidation (GO:0019395)2.93444297
108lactate metabolic process (GO:0006089)2.92730499
109dicarboxylic acid catabolic process (GO:0043649)2.89097657
110positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.87991551
111response to methylmercury (GO:0051597)2.85359749
112triglyceride catabolic process (GO:0019433)2.85262049
113hydrogen ion transmembrane transport (GO:1902600)2.84032223
114cellular glucuronidation (GO:0052695)2.83789742
115antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.83343149
116establishment of integrated proviral latency (GO:0075713)2.82480941
117positive regulation of fatty acid beta-oxidation (GO:0032000)2.81773300
118signal peptide processing (GO:0006465)2.80574769
119phospholipid efflux (GO:0033700)2.79639680
120positive regulation of cellular amine metabolic process (GO:0033240)2.79589693
121cullin deneddylation (GO:0010388)2.79440083
122regulation of mitochondrial translation (GO:0070129)2.78593168
123regulation of plasminogen activation (GO:0010755)2.78386171
124positive regulation of ligase activity (GO:0051351)2.78320036
125acylglycerol catabolic process (GO:0046464)2.77931038
126neutral lipid catabolic process (GO:0046461)2.77931038
127mitochondrial respiratory chain complex assembly (GO:0033108)2.77688068
128positive regulation of fatty acid oxidation (GO:0046321)2.76459910
129protein neddylation (GO:0045116)2.76258203
130regulation of cholesterol biosynthetic process (GO:0045540)2.75159367
131fatty-acyl-CoA biosynthetic process (GO:0046949)2.74796437
132vitamin biosynthetic process (GO:0009110)2.73935847
133linoleic acid metabolic process (GO:0043651)2.73157462
134positive regulation of triglyceride metabolic process (GO:0090208)2.72925742
135regulation of lipid catabolic process (GO:0050994)2.72580391
136ethanol oxidation (GO:0006069)2.72026461
137platelet dense granule organization (GO:0060155)2.71745032
138biotin metabolic process (GO:0006768)2.71115744
139fatty-acyl-CoA metabolic process (GO:0035337)2.70470287
140monocarboxylic acid catabolic process (GO:0072329)2.70173523
141alpha-amino acid catabolic process (GO:1901606)2.70125398
142triglyceride homeostasis (GO:0070328)2.69533710
143acylglycerol homeostasis (GO:0055090)2.69533710
144positive regulation of extracellular matrix organization (GO:1903055)2.68885520
145one-carbon compound transport (GO:0019755)2.68441038
146tryptophan catabolic process (GO:0006569)2.68349739
147indole-containing compound catabolic process (GO:0042436)2.68349739
148indolalkylamine catabolic process (GO:0046218)2.68349739
149complement activation, alternative pathway (GO:0006957)2.67530020
150peroxisome fission (GO:0016559)2.67250188
151ATP biosynthetic process (GO:0006754)2.67043035
152long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.66365699
153positive regulation of lipid catabolic process (GO:0050996)2.64752529
154neurotransmitter uptake (GO:0001504)2.64547343
155CTP metabolic process (GO:0046036)2.63682026
156CTP biosynthetic process (GO:0006241)2.63682026
157glucuronate metabolic process (GO:0019585)2.62437120
158uronic acid metabolic process (GO:0006063)2.62437120
159regulation of cholesterol metabolic process (GO:0090181)2.62327219
160tryptophan metabolic process (GO:0006568)2.62003051
161serine family amino acid catabolic process (GO:0009071)2.60223761
162bile acid metabolic process (GO:0008206)2.59955028
163glutamate metabolic process (GO:0006536)2.59905924
164glutathione derivative metabolic process (GO:1901685)2.59857403
165glutathione derivative biosynthetic process (GO:1901687)2.59857403
166long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.59762685
167serine family amino acid biosynthetic process (GO:0009070)2.59072168
168cellular amino acid catabolic process (GO:0009063)2.57893514
169pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.57648726
170response to nitrosative stress (GO:0051409)2.57531984
171acyl-CoA metabolic process (GO:0006637)2.57055522

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.56339977
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.99589648
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.62819218
4GABP_17652178_ChIP-ChIP_JURKAT_Human4.19973957
5CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human3.49613857
6* RXR_22158963_ChIP-Seq_LIVER_Mouse3.40370412
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.38213463
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.37157027
9* PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.26130447
10* LXR_22158963_ChIP-Seq_LIVER_Mouse3.16751442
11CREB1_15753290_ChIP-ChIP_HEK293T_Human3.07486624
12TRIM28_21343339_ChIP-Seq_HEK293_Human3.05728255
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.03080206
14* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.80050415
15EGR1_23403033_ChIP-Seq_LIVER_Mouse2.72942812
16* ELK1_19687146_ChIP-ChIP_HELA_Human2.66907088
17RBPJ_22232070_ChIP-Seq_NCS_Mouse2.59385361
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.48575160
19* PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.42786108
20SRF_21415370_ChIP-Seq_HL-1_Mouse2.41874150
21PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.40498475
22HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.29574256
23ETS1_20019798_ChIP-Seq_JURKAT_Human2.24898244
24* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.24037747
25TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.23477215
26ELF1_17652178_ChIP-ChIP_JURKAT_Human2.16916333
27* AR_21909140_ChIP-Seq_LNCAP_Human2.14100089
28MYC_18555785_ChIP-Seq_MESCs_Mouse2.11370725
29SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.05564588
30TP63_17297297_ChIP-ChIP_HaCaT_Human1.98088811
31E2F1_18555785_ChIP-Seq_MESCs_Mouse1.88601867
32CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.88487096
33CLOCK_20551151_ChIP-Seq_293T_Human1.84387858
34* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.83917812
35FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.83882381
36AR_21572438_ChIP-Seq_LNCaP_Human1.82267159
37PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.76537792
38PADI4_21655091_ChIP-ChIP_MCF-7_Human1.73745835
39* VDR_23849224_ChIP-Seq_CD4+_Human1.69783612
40MYC_19030024_ChIP-ChIP_MESCs_Mouse1.68275396
41MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.67328177
42HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.66430409
43CDX2_19796622_ChIP-Seq_MESCs_Mouse1.66338939
44SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.65859521
45* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.63969216
46FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.62813975
47FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.55140178
48SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.54005531
49DCP1A_22483619_ChIP-Seq_HELA_Human1.53716939
50E2F4_17652178_ChIP-ChIP_JURKAT_Human1.52841898
51SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.52757296
52FOXP3_21729870_ChIP-Seq_TREG_Human1.50677354
53SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.50188991
54NELFA_20434984_ChIP-Seq_ESCs_Mouse1.47533052
55HOXB4_20404135_ChIP-ChIP_EML_Mouse1.44109444
56PIAS1_25552417_ChIP-Seq_VCAP_Human1.42881550
57TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.41026854
58SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.40456329
59EED_16625203_ChIP-ChIP_MESCs_Mouse1.40201532
60EZH2_18974828_ChIP-Seq_MESCs_Mouse1.39571145
61RNF2_18974828_ChIP-Seq_MESCs_Mouse1.39571145
62NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.38011223
63ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.37661117
64MTF2_20144788_ChIP-Seq_MESCs_Mouse1.37592406
65EZH2_27294783_Chip-Seq_ESCs_Mouse1.36553713
66JARID2_20075857_ChIP-Seq_MESCs_Mouse1.35163253
67CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.34957368
68HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.34217796
69JARID2_20064375_ChIP-Seq_MESCs_Mouse1.32078618
70* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.31624140
71* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.30300844
72CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.30247986
73FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.26709146
74GABP_19822575_ChIP-Seq_HepG2_Human1.26034489
75SUZ12_27294783_Chip-Seq_ESCs_Mouse1.25424243
76PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.24774112
77ELK1_22589737_ChIP-Seq_MCF10A_Human1.24428434
78SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.22851578
79* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.21394282
80EZH2_27304074_Chip-Seq_ESCs_Mouse1.21086497
81SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.20783164
82IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.19874595
83SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19568787
84RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.17328845
85NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.17118381
86NRF2_20460467_ChIP-Seq_MEFs_Mouse1.17118381
87HTT_18923047_ChIP-ChIP_STHdh_Human1.16665253
88ERG_21242973_ChIP-ChIP_JURKAT_Human1.15997022
89POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.15506368
90* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.15461450
91RARG_19884340_ChIP-ChIP_MEFs_Mouse1.15272656
92ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.14416576
93FLI1_27457419_Chip-Seq_LIVER_Mouse1.14332052
94CTBP2_25329375_ChIP-Seq_LNCAP_Human1.13759308
95PCGF2_27294783_Chip-Seq_ESCs_Mouse1.09667127
96PPAR_26484153_Chip-Seq_NCI-H1993_Human1.08058756
97E2F7_22180533_ChIP-Seq_HELA_Human1.07751027
98P300_19829295_ChIP-Seq_ESCs_Human1.07406902
99SALL4_18804426_ChIP-ChIP_XEN_Mouse1.07313623
100* BCAT_22108803_ChIP-Seq_LS180_Human1.06921123
101MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.06803238
102TFEB_21752829_ChIP-Seq_HELA_Human1.06116786
103RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.05544648
104MYC_19079543_ChIP-ChIP_MESCs_Mouse1.05391854
105ESR2_21235772_ChIP-Seq_MCF-7_Human1.05156232
106NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04343525
107SOX17_20123909_ChIP-Seq_XEN_Mouse1.04336331
108CTBP1_25329375_ChIP-Seq_LNCAP_Human1.04179684
109NANOG_18555785_ChIP-Seq_MESCs_Mouse1.03794250
110SMAD3_21741376_ChIP-Seq_EPCs_Human1.02034215
111* NFE2_27457419_Chip-Seq_LIVER_Mouse1.00824984
112EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.99851476
113CBX2_27304074_Chip-Seq_ESCs_Mouse0.99303071
114* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99272625
115ZNF217_24962896_ChIP-Seq_MCF-7_Human0.98547074
116TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.97180617
117EZH2_27294783_Chip-Seq_NPCs_Mouse0.97076663
118SOX9_24532713_ChIP-Seq_HFSC_Mouse0.97042477
119GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96697681
120TP53_20018659_ChIP-ChIP_R1E_Mouse0.96241757
121RXR_22108803_ChIP-Seq_LS180_Human0.96001878
122CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.95948356
123RNF2_27304074_Chip-Seq_ESCs_Mouse0.95762442
124AUTS2_25519132_ChIP-Seq_293T-REX_Human0.95112193
125SMAD4_21799915_ChIP-Seq_A2780_Human0.95040701
126THAP11_20581084_ChIP-Seq_MESCs_Mouse0.93970275
127TP53_18474530_ChIP-ChIP_U2OS_Human0.93786381
128EP300_21415370_ChIP-Seq_HL-1_Mouse0.93584233
129TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93281018
130* CJUN_26792858_Chip-Seq_BT549_Human0.92815483
131PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.92167189
132LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91433997
133AR_20517297_ChIP-Seq_VCAP_Human0.91418099
134SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.91304811
135SALL4_22934838_ChIP-ChIP_CD34+_Human0.90515679
136CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.89714758
137SOX2_20726797_ChIP-Seq_SW620_Human0.89335329
138WT1_19549856_ChIP-ChIP_CCG9911_Human0.88509595
139SMAD4_21741376_ChIP-Seq_EPCs_Human0.88261699
140ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.88130916
141PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.87292392
142RING1B_27294783_Chip-Seq_ESCs_Mouse0.85775429
143OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.85735121
144SOX2_19829295_ChIP-Seq_ESCs_Human0.85618786
145NANOG_19829295_ChIP-Seq_ESCs_Human0.85618786
146YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.85282846
147TAF15_26573619_Chip-Seq_HEK293_Human0.85175727
148EOMES_21245162_ChIP-Seq_HESCs_Human0.85054077
149* CRX_20693478_ChIP-Seq_RETINA_Mouse0.85036944
150YY1_21170310_ChIP-Seq_MESCs_Mouse0.84642921
151* SUZ12_27294783_Chip-Seq_NPCs_Mouse0.84595062
152RAD21_21589869_ChIP-Seq_MESCs_Mouse0.84124140
153* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.84087685
154PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.84031364
155TTF2_22483619_ChIP-Seq_HELA_Human0.83371137
156FOXA2_19822575_ChIP-Seq_HepG2_Human0.82770341
157SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.82641817
158PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.82404949
159FOXA1_25329375_ChIP-Seq_VCAP_Human0.81926849
160FOXA1_27270436_Chip-Seq_PROSTATE_Human0.81926849
161NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.81875713
162SMAD4_21741376_ChIP-Seq_HESCs_Human0.81018287
163TOP2B_26459242_ChIP-Seq_MCF-7_Human0.80297028
164ESR1_21235772_ChIP-Seq_MCF-7_Human0.79901835
165POU3F2_20337985_ChIP-ChIP_501MEL_Human0.79685126
166SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.79227200
167ERG_20517297_ChIP-Seq_VCAP_Human0.79071052
168ZFX_18555785_ChIP-Seq_MESCs_Mouse0.79050815
169POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.78709733
170STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.78046650
171FOXM1_26456572_ChIP-Seq_MCF-7_Human0.77835984
172PCGF2_27294783_Chip-Seq_NPCs_Mouse0.77603622
173FOXO3_23340844_ChIP-Seq_DLD1_Human0.77307658
174PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.77097283
175* P300_18555785_Chip-Seq_ESCs_Mouse0.76650882
176AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.76490875
177SMC3_22415368_ChIP-Seq_MEFs_Mouse0.76119737
178TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.75347348
179* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.75280470
180GATA1_26923725_Chip-Seq_HPCs_Mouse0.74185856
181STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.73409922

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color5.10527799
2MP0005360_urolithiasis4.85449781
3MP0002139_abnormal_hepatobiliary_system4.57772808
4MP0003011_delayed_dark_adaptation3.20235856
5MP0005085_abnormal_gallbladder_physiolo3.14184490
6MP0003690_abnormal_glial_cell3.12196470
7MP0005365_abnormal_bile_salt3.10308833
8MP0008875_abnormal_xenobiotic_pharmacok3.02562606
9MP0002736_abnormal_nociception_after2.75321721
10MP0010329_abnormal_lipoprotein_level2.51415636
11MP0006036_abnormal_mitochondrial_physio2.49398547
12MP0002653_abnormal_ependyma_morphology2.42217391
13MP0003868_abnormal_feces_composition2.40411748
14MP0005332_abnormal_amino_acid2.35152036
15MP0005670_abnormal_white_adipose2.28570883
16MP0003941_abnormal_skin_development2.28385875
17MP0009840_abnormal_foam_cell2.18205440
18MP0005408_hypopigmentation2.11777274
19MP0004381_abnormal_hair_follicle2.02049891
20MP0005058_abnormal_lysosome_morphology1.84301397
21MP0003252_abnormal_bile_duct1.83782675
22MP0003186_abnormal_redox_activity1.80053447
23MP0003329_amyloid_beta_deposits1.79142052
24MP0009384_cardiac_valve_regurgitation1.75904980
25MP0004858_abnormal_nervous_system1.75518512
26MP0004019_abnormal_vitamin_homeostasis1.74395494
27MP0002163_abnormal_gland_morphology1.73054429
28MP0002118_abnormal_lipid_homeostasis1.68321682
29MP0003634_abnormal_glial_cell1.67597108
30MP0002249_abnormal_larynx_morphology1.60941672
31MP0000920_abnormal_myelination1.54974522
32MP0002909_abnormal_adrenal_gland1.52776724
33MP0002254_reproductive_system_inflammat1.51698853
34MP0001727_abnormal_embryo_implantation1.49083057
35MP0001666_abnormal_nutrient_absorption1.46464854
36MP0008058_abnormal_DNA_repair1.46253143
37MP0000372_irregular_coat_pigmentation1.43673589
38MP0005646_abnormal_pituitary_gland1.43071702
39MP0003806_abnormal_nucleotide_metabolis1.43012798
40MP0008004_abnormal_stomach_pH1.42789272
41MP0000343_altered_response_to1.37693570
42MP0000604_amyloidosis1.37388895
43MP0001661_extended_life_span1.37344895
44MP0002837_dystrophic_cardiac_calcinosis1.37074654
45MP0006072_abnormal_retinal_apoptosis1.35466796
46MP0003191_abnormal_cellular_cholesterol1.33842837
47MP0006054_spinal_hemorrhage1.32898578
48MP0005623_abnormal_meninges_morphology1.32820949
49MP0005083_abnormal_biliary_tract1.32531903
50MP0001485_abnormal_pinna_reflex1.30372220
51MP0001440_abnormal_grooming_behavior1.27661287
52MP0010094_abnormal_chromosome_stability1.27526960
53MP0005253_abnormal_eye_physiology1.25187807
54MP0005666_abnormal_adipose_tissue1.24402678
55MP0003195_calcinosis1.18150202
56MP0002638_abnormal_pupillary_reflex1.17242234
57MP0002282_abnormal_trachea_morphology1.15692325
58MP0006082_CNS_inflammation1.15411567
59MP0009643_abnormal_urine_homeostasis1.14293840
60MP0002971_abnormal_brown_adipose1.13649627
61MP0004957_abnormal_blastocyst_morpholog1.13215410
62MP0004885_abnormal_endolymph1.13106520
63MP0003724_increased_susceptibility_to1.10847134
64MP0005584_abnormal_enzyme/coenzyme_acti1.09034291
65MP0003075_altered_response_to1.06909333
66MP0002876_abnormal_thyroid_physiology1.06545287
67MP0000609_abnormal_liver_physiology1.06480194
68MP0003950_abnormal_plasma_membrane1.05341541
69MP0003718_maternal_effect1.05030734
70MP0001905_abnormal_dopamine_level1.04302488
71MP0000579_abnormal_nail_morphology1.03779055
72MP0005647_abnormal_sex_gland1.01642876
73MP0005379_endocrine/exocrine_gland_phen0.99098546
74MP0001881_abnormal_mammary_gland0.98554867
75MP0001529_abnormal_vocalization0.98321395
76MP0001968_abnormal_touch/_nociception0.97864615
77MP0004130_abnormal_muscle_cell0.97617327
78MP0005171_absent_coat_pigmentation0.97608980
79MP0002796_impaired_skin_barrier0.96966127
80MP0008007_abnormal_cellular_replicative0.96763329
81MP0005448_abnormal_energy_balance0.96230444
82MP0001958_emphysema0.95895934
83MP0004742_abnormal_vestibular_system0.93843791
84MP0005275_abnormal_skin_tensile0.92392153
85MP0002970_abnormal_white_adipose0.92021470
86MP0000516_abnormal_urinary_system0.91965830
87MP0005367_renal/urinary_system_phenotyp0.91965830
88MP0005319_abnormal_enzyme/_coenzyme0.91770037
89MP0002078_abnormal_glucose_homeostasis0.90931622
90MP0002148_abnormal_hypersensitivity_rea0.90629204
91MP0002090_abnormal_vision0.90241819
92MP0001853_heart_inflammation0.89080984
93MP0005451_abnormal_body_composition0.87665939
94MP0002295_abnormal_pulmonary_circulatio0.87057869
95MP0004272_abnormal_basement_membrane0.86879762
96MP0000383_abnormal_hair_follicle0.85948024
97MP0000647_abnormal_sebaceous_gland0.85119904
98MP0004142_abnormal_muscle_tone0.83759494
99MP0002168_other_aberrant_phenotype0.82691093
100MP0009115_abnormal_fat_cell0.82585279
101MP0005636_abnormal_mineral_homeostasis0.82127840
102MP0005166_decreased_susceptibility_to0.81957908
103MP0009379_abnormal_foot_pigmentation0.81893831
104MP0005165_increased_susceptibility_to0.81551634
105MP0005084_abnormal_gallbladder_morpholo0.79676591
106MP0005671_abnormal_response_to0.77275998
107MP0009785_altered_susceptibility_to0.76666483
108MP0005452_abnormal_adipose_tissue0.76541021
109MP0004133_heterotaxia0.74541929
110MP0001177_atelectasis0.74530616
111MP0001756_abnormal_urination0.74449405
112MP0000462_abnormal_digestive_system0.74038646
113MP0008872_abnormal_physiological_respon0.73273145
114MP0001764_abnormal_homeostasis0.73209627
115MP0003633_abnormal_nervous_system0.72331871
116MP0005551_abnormal_eye_electrophysiolog0.72182460
117MP0002133_abnormal_respiratory_system0.71737937
118MP0005388_respiratory_system_phenotype0.71737937
119MP0003172_abnormal_lysosome_physiology0.71552168
120MP0005535_abnormal_body_temperature0.70915323
121MP0002089_abnormal_postnatal_growth/wei0.70488829
122MP0005595_abnormal_vascular_smooth0.70087887
123MP0004185_abnormal_adipocyte_glucose0.69740367
124MP0002928_abnormal_bile_duct0.69737828
125MP0000026_abnormal_inner_ear0.69631944
126MP0006035_abnormal_mitochondrial_morpho0.69559907
127MP0008469_abnormal_protein_level0.69201316
128MP0004043_abnormal_pH_regulation0.68963652
129MP0000778_abnormal_nervous_system0.68315133
130MP0005167_abnormal_blood-brain_barrier0.67881194
131MP0003123_paternal_imprinting0.67291988
132MP0005220_abnormal_exocrine_pancreas0.67111262
133MP0003953_abnormal_hormone_level0.66836631
134MP0001984_abnormal_olfaction0.66738801
135MP0003938_abnormal_ear_development0.66674679
136MP0003656_abnormal_erythrocyte_physiolo0.65197837
137MP0001851_eye_inflammation0.64964621
138MP0010307_abnormal_tumor_latency0.64109704
139MP0003638_abnormal_response/metabolism_0.63835780
140MP0010678_abnormal_skin_adnexa0.63682516
141MP0001944_abnormal_pancreas_morphology0.63203674
142MP0002938_white_spotting0.62644892
143MP0001501_abnormal_sleep_pattern0.62108501
144MP0010386_abnormal_urinary_bladder0.61650863
145MP0000358_abnormal_cell_content/0.60805344
146MP0005164_abnormal_response_to0.60700495
147MP0003937_abnormal_limbs/digits/tail_de0.60242019
148MP0001486_abnormal_startle_reflex0.59550632

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.82372125
2Respiratory insufficiency due to defective ciliary clearance (HP:0200073)9.73727342
3Abnormal ciliary motility (HP:0012262)9.21062927
4Rhinitis (HP:0012384)8.57932412
5Abnormal respiratory motile cilium morphology (HP:0005938)6.57756944
6Abnormal respiratory epithelium morphology (HP:0012253)6.57756944
7Chronic bronchitis (HP:0004469)5.11777987
8Abnormal mitochondria in muscle tissue (HP:0008316)4.44439432
9Increased serum pyruvate (HP:0003542)4.39244554
10Mitochondrial inheritance (HP:0001427)4.18734792
11Bronchiectasis (HP:0002110)4.17188354
12Abnormality of glycolysis (HP:0004366)4.00034708
13Increased CSF lactate (HP:0002490)3.91932958
14Increased hepatocellular lipid droplets (HP:0006565)3.75000942
15Hepatic necrosis (HP:0002605)3.66477919
16Hyperglycinuria (HP:0003108)3.59947634
17Lipid accumulation in hepatocytes (HP:0006561)3.58719462
18Renal Fanconi syndrome (HP:0001994)3.53762277
19Abnormality of glycine metabolism (HP:0010895)3.49308975
20Abnormality of serine family amino acid metabolism (HP:0010894)3.49308975
21Decreased activity of mitochondrial respiratory chain (HP:0008972)3.46108935
22Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.46108935
23Hepatocellular necrosis (HP:0001404)3.40724176
24Dynein arm defect of respiratory motile cilia (HP:0012255)3.36518677
25Absent/shortened dynein arms (HP:0200106)3.36518677
26Xanthomatosis (HP:0000991)3.32017547
273-Methylglutaconic aciduria (HP:0003535)3.27002452
28Intrahepatic cholestasis (HP:0001406)3.26218997
29Recurrent sinusitis (HP:0011108)3.20976033
30Abnormality of aromatic amino acid family metabolism (HP:0004338)3.15545639
31Respiratory failure (HP:0002878)3.12337756
32Abnormal biliary tract physiology (HP:0012439)2.95082862
33Bile duct proliferation (HP:0001408)2.95082862
34Lactic acidosis (HP:0003128)2.91328511
35Generalized aminoaciduria (HP:0002909)2.88985656
36Abnormality of serum amino acid levels (HP:0003112)2.82867653
37Systemic lupus erythematosus (HP:0002725)2.81986983
38Hypoglycemic seizures (HP:0002173)2.81095849
39Increased intramyocellular lipid droplets (HP:0012240)2.80924472
40Multiple enchondromatosis (HP:0005701)2.78970723
41Deep venous thrombosis (HP:0002625)2.78938674
42True hermaphroditism (HP:0010459)2.78253247
43Leukodystrophy (HP:0002415)2.77853114
44Nausea (HP:0002018)2.74713997
45Back pain (HP:0003418)2.74579149
46Hyperlipoproteinemia (HP:0010980)2.73228140
47Ketosis (HP:0001946)2.73108978
48Vacuolated lymphocytes (HP:0001922)2.72101752
49Increased muscle lipid content (HP:0009058)2.70097874
50Exertional dyspnea (HP:0002875)2.67363470
51Increased serum lactate (HP:0002151)2.67043462
52Pancreatic fibrosis (HP:0100732)2.63639428
53CNS demyelination (HP:0007305)2.61247343
54Hyperammonemia (HP:0001987)2.58178653
55Abnormality of liposaccharide metabolism (HP:0010968)2.58157816
56Abnormality of glycosphingolipid metabolism (HP:0004343)2.58157816
57Abnormality of glycolipid metabolism (HP:0010969)2.58157816
58Hypobetalipoproteinemia (HP:0003563)2.54170803
59Abnormality of glutamine family amino acid metabolism (HP:0010902)2.51485847
60Poor head control (HP:0002421)2.50752216
61Abnormality of aspartate family amino acid metabolism (HP:0010899)2.50700808
62Abnormality of the axillary hair (HP:0100134)2.50071236
63Abnormality of secondary sexual hair (HP:0009888)2.50071236
64Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.49626779
65Abnormality of methionine metabolism (HP:0010901)2.49553442
66Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.48941990
67Median cleft lip (HP:0000161)2.48836263
68Hyperglycinemia (HP:0002154)2.48701337
69Exercise intolerance (HP:0003546)2.48633126
70Symptomatic seizures (HP:0011145)2.47951413
71Abnormality of monocarboxylic acid metabolism (HP:0010996)2.45360512
72Nasal polyposis (HP:0100582)2.44262632
73Neurofibrillary tangles (HP:0002185)2.43233580
74Ketoacidosis (HP:0001993)2.42461829
75Esophageal neoplasm (HP:0100751)2.40506696
76Neoplasm of head and neck (HP:0012288)2.40506696
77Abnormality of urine glucose concentration (HP:0011016)2.40216016
78Glycosuria (HP:0003076)2.40216016
79Hypoglycemic coma (HP:0001325)2.39173527
80Hypoalphalipoproteinemia (HP:0003233)2.38493120
81Neonatal short-limb short stature (HP:0008921)2.35659655
82Megalencephaly (HP:0001355)2.34599727
83Hypolipoproteinemia (HP:0010981)2.33243057
84Neoplasm of the adrenal gland (HP:0100631)2.32791843
85Congenital ichthyosiform erythroderma (HP:0007431)2.32278799
86Methylmalonic acidemia (HP:0002912)2.31282324
87Prolonged partial thromboplastin time (HP:0003645)2.26117010
88Sex reversal (HP:0012245)2.22519261
89Abnormal sex determination (HP:0012244)2.22519261
90Abdominal situs inversus (HP:0003363)2.21945567
91Abnormality of abdominal situs (HP:0011620)2.21945567
92Complement deficiency (HP:0004431)2.21860996
93Methylmalonic aciduria (HP:0012120)2.20597071
94Type I transferrin isoform profile (HP:0003642)2.17010822
95Hyperinsulinemic hypoglycemia (HP:0000825)2.15068600
96Hemiparesis (HP:0001269)2.13577409
97Hydroxyprolinuria (HP:0003080)2.13302678
98Abnormality of proline metabolism (HP:0010907)2.13302678
99Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.12900966
100Reduced antithrombin III activity (HP:0001976)2.11016462
101Amyloidosis (HP:0011034)2.10701243
102Glomerulonephritis (HP:0000099)2.09558139
103Delayed CNS myelination (HP:0002188)2.07099911
104Cerebral edema (HP:0002181)2.05632382
105Agnosia (HP:0010524)2.05470780
106Abnormality of dentin (HP:0010299)2.04939504
107Abnormality of the anterior horn cell (HP:0006802)2.03854907
108Degeneration of anterior horn cells (HP:0002398)2.03854907
109Abnormality of renal resorption (HP:0011038)2.03216131
110Axonal loss (HP:0003447)2.02947554
111Optic disc pallor (HP:0000543)2.02651259
112Abnormality of placental membranes (HP:0011409)2.02084249
113Amniotic constriction ring (HP:0009775)2.02084249
114Hyperphosphaturia (HP:0003109)1.99875075
115Postural tremor (HP:0002174)1.98376983
116Bronchitis (HP:0012387)1.98214238
117Steatorrhea (HP:0002570)1.97561065
118Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.95682978
119Prolonged neonatal jaundice (HP:0006579)1.94320667
120Chronic hepatic failure (HP:0100626)1.93472234
121Spastic paraparesis (HP:0002313)1.93107973
122Abnormal cartilage morphology (HP:0002763)1.92216081
123Bronchomalacia (HP:0002780)1.91171121
124Abnormality of the nasal mucosa (HP:0000433)1.90234667
125Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.89589021
126Respiratory distress (HP:0002098)1.89502392
127Vomiting (HP:0002013)1.88985443
128Conjunctival hamartoma (HP:0100780)1.88724526
129Abnormality of fatty-acid metabolism (HP:0004359)1.87861516
130Recurrent otitis media (HP:0000403)1.87603057
131Opisthotonus (HP:0002179)1.87509981
132Epidermoid cyst (HP:0200040)1.86036581
133Spastic diplegia (HP:0001264)1.85649296
134Acute encephalopathy (HP:0006846)1.85138215
135Fibular hypoplasia (HP:0003038)1.84907149
136Metabolic acidosis (HP:0001942)1.84244451
137Sensorimotor neuropathy (HP:0007141)1.83580500
138Dicarboxylic aciduria (HP:0003215)1.83306233
139Abnormality of dicarboxylic acid metabolism (HP:0010995)1.83306233
140Abnormality of the dental root (HP:0006486)1.81946730
141Taurodontia (HP:0000679)1.81946730
142Abnormality of permanent molar morphology (HP:0011071)1.81946730
143Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.80959473
144Abnormality of alanine metabolism (HP:0010916)1.80959473
145Hyperalaninemia (HP:0003348)1.80959473
146Abnormality of the dental pulp (HP:0006479)1.79692153
147Renal tubular dysfunction (HP:0000124)1.78529143
148Lethargy (HP:0001254)1.73678916
149Abnormality of molar morphology (HP:0011070)1.71272149
150Abnormality of molar (HP:0011077)1.71272149
151Prenatal maternal abnormality (HP:0002686)1.66589145
152Confusion (HP:0001289)1.65844944
153Occipital encephalocele (HP:0002085)1.64990386
154Fat malabsorption (HP:0002630)1.63928221
155Concave nail (HP:0001598)1.62927192
156Pancreatic cysts (HP:0001737)1.62412040
157Abnormal urine output (HP:0012590)1.62281734
158Aplasia of the phalanges of the hand (HP:0009802)1.60728648
159Aplasia involving bones of the extremities (HP:0009825)1.60728648
160Aplasia involving bones of the upper limbs (HP:0009823)1.60728648
161Postaxial foot polydactyly (HP:0001830)1.57688183
162Tubulointerstitial nephritis (HP:0001970)1.57464393
163Abnormal drinking behavior (HP:0030082)1.56590281
164Polydipsia (HP:0001959)1.56590281
165Pili torti (HP:0003777)1.56434082
166Follicular hyperkeratosis (HP:0007502)1.55834144
167Degeneration of the lateral corticospinal tracts (HP:0002314)1.55538995
168Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.55538995
169Metabolic alkalosis (HP:0200114)1.55271127
170Cerebral inclusion bodies (HP:0100314)1.54259096
171Bifid scrotum (HP:0000048)1.53752023
172Parakeratosis (HP:0001036)1.52481308
173Progressive macrocephaly (HP:0004481)1.52037506
174Acute necrotizing encephalopathy (HP:0006965)1.50853520

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK156.06326228
2PNCK4.29805692
3MST44.21528253
4SIK13.65672303
5MAP3K123.50106561
6VRK23.14542244
7EIF2AK33.13554965
8NEK13.02355841
9PDK22.94044748
10EIF2AK12.78199787
11BCKDK2.76946116
12STK392.46503347
13LMTK22.36920163
14STK162.33291618
15NME22.12357202
16BUB12.08375388
17PBK2.05917610
18LRRK21.98107067
19NTRK21.92082738
20OXSR11.90407238
21ZAK1.83214767
22BMPR1B1.82146939
23IRAK21.76185397
24MST1R1.71657953
25TESK11.70947337
26MAP2K21.69207639
27ROCK21.67375055
28MKNK21.66258102
29PHKG11.64167947
30PHKG21.64167947
31GRK11.61053217
32WNK31.58473483
33SRPK11.51744438
34CDC71.49413652
35GSK3A1.46783237
36PLK31.41421107
37SGK2231.34381079
38SGK4941.34381079
39CSNK1G21.33607250
40BRSK21.31815506
41NUAK11.31530599
42ACVR1B1.31488573
43TTK1.31080795
44EPHB11.28756033
45STK101.27920707
46TRIB31.27017701
47PLK21.26577867
48ROCK11.22057695
49MAPKAPK51.21503310
50ERBB31.20165751
51PKN11.18595305
52PAK41.17537886
53IRAK11.16538519
54CASK1.14476606
55MYLK1.12840144
56TRIM281.12182734
57WNK41.10713668
58BCR1.10636708
59FRK1.10223070
60TYRO31.09935629
61CSNK1G11.08287403
62ERBB41.04862489
63STK38L1.04346351
64PAK21.02577516
65MUSK1.00534330
66TSSK60.98899633
67LIMK10.97967999
68MKNK10.97784414
69MET0.97631047
70BMPR20.97259999
71MAPK120.95150381
72NME10.94815153
73DAPK10.94675540
74PLK40.94650449
75ADRBK10.93019892
76NLK0.92166507
77ABL20.86293485
78PAK30.84870146
79SCYL20.84116450
80CCNB10.82890030
81PLK10.82876857
82NEK90.81927770
83VRK10.80914113
84TAF10.79713150
85EIF2AK20.79161228
86BRSK10.78604647
87PRKAA20.78192274
88PRKCQ0.77659385
89PRKCE0.77485862
90ERN10.76911298
91CDK30.75009977
92MAP3K20.74615590
93TNIK0.74409541
94CAMK2G0.73039611
95FGFR20.70875155
96KDR0.70261776
97PRKACG0.69475303
98ADRBK20.69242177
99MAPKAPK30.68300884
100MAPK40.66811439
101DAPK30.64959198
102MAP3K90.64590027
103PTK60.64093854
104PIK3CG0.60898081
105CAMK2B0.60745756
106PRKCG0.59755021
107CSNK2A10.59185630
108PRKACA0.57426174
109PRKG10.56566928
110TRPM70.56041927
111CSNK1G30.55989080
112DAPK20.55798832
113CAMK2D0.54737814
114FGFR40.53981751
115CSNK2A20.53887225
116PRKD10.51633246
117DYRK20.50272088
118MAPK70.49804433
119FGR0.48819488
120AURKB0.48440044
121SGK20.48325789
122CAMK2A0.47388306
123NTRK10.47313520
124SRC0.46786361
125MAP2K10.46601883
126IGF1R0.45412719
127LATS10.44281210
128CSNK1A10.44141958
129FER0.43250146
130ALK0.42340448
131PIM20.41347337
132GRK60.41135285
133PRKCZ0.41118536
134DMPK0.41063585
135ABL10.40869425
136PRKCA0.39783954
137YES10.38733898
138ARAF0.38674368
139TLK10.38487209
140CSK0.38443505
141MARK10.38057037
142MAP4K20.37649784
143ILK0.36221191
144PIK3CA0.36167257
145MOS0.35980216
146PRKD30.35347574
147STK240.35103165
148ITK0.34769022
149CSNK1E0.34527143
150PRKCH0.34331250
151CSNK1A1L0.33738823
152PRKCI0.33394820
153JAK10.33373102
154NEK60.32252442
155CDK60.32059169
156AKT20.31975413
157BMX0.31766150
158TESK20.31225858
159WEE10.30244854
160OBSCN0.29790630
161GRK70.29594597

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.39717542
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.69541446
3Proteasome_Homo sapiens_hsa030503.64747515
4Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.27437543
5Primary bile acid biosynthesis_Homo sapiens_hsa001202.97904029
6Protein export_Homo sapiens_hsa030602.82245503
7Fatty acid elongation_Homo sapiens_hsa000622.65006338
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.62041350
9Butanoate metabolism_Homo sapiens_hsa006502.59687872
10Fatty acid degradation_Homo sapiens_hsa000712.56841906
11Propanoate metabolism_Homo sapiens_hsa006402.47170357
12Fatty acid metabolism_Homo sapiens_hsa012122.33949522
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.29278206
14* PPAR signaling pathway_Homo sapiens_hsa033202.23838683
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.12154228
16Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.09935257
17Tryptophan metabolism_Homo sapiens_hsa003802.08865260
18Peroxisome_Homo sapiens_hsa041462.05358305
19Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.98647037
20Histidine metabolism_Homo sapiens_hsa003401.97616261
21Arginine biosynthesis_Homo sapiens_hsa002201.82499177
22Pentose and glucuronate interconversions_Homo sapiens_hsa000401.79517196
23Steroid biosynthesis_Homo sapiens_hsa001001.72186772
24Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.70175188
25Complement and coagulation cascades_Homo sapiens_hsa046101.65604577
26Chemical carcinogenesis_Homo sapiens_hsa052041.64863504
27Retinol metabolism_Homo sapiens_hsa008301.60476552
28Fatty acid biosynthesis_Homo sapiens_hsa000611.59493681
29Sulfur metabolism_Homo sapiens_hsa009201.53573684
30Vitamin B6 metabolism_Homo sapiens_hsa007501.47806145
31Pyruvate metabolism_Homo sapiens_hsa006201.45519622
32Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.44395305
33Steroid hormone biosynthesis_Homo sapiens_hsa001401.43450442
34beta-Alanine metabolism_Homo sapiens_hsa004101.39410442
35Mismatch repair_Homo sapiens_hsa034301.35980106
36Caffeine metabolism_Homo sapiens_hsa002321.34441212
37Tyrosine metabolism_Homo sapiens_hsa003501.33167039
38Bile secretion_Homo sapiens_hsa049761.31382929
39Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.30554116
40Oxidative phosphorylation_Homo sapiens_hsa001901.20925012
41Glutathione metabolism_Homo sapiens_hsa004801.19470815
42RNA polymerase_Homo sapiens_hsa030201.16895334
43Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.13960237
44Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.13157865
45Phenylalanine metabolism_Homo sapiens_hsa003601.10624796
46Fat digestion and absorption_Homo sapiens_hsa049751.07514256
47Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.04978000
48Arginine and proline metabolism_Homo sapiens_hsa003301.01595560
49Carbon metabolism_Homo sapiens_hsa012001.00781380
50Vitamin digestion and absorption_Homo sapiens_hsa049770.98471452
51Huntingtons disease_Homo sapiens_hsa050160.98021580
52Staphylococcus aureus infection_Homo sapiens_hsa051500.97994106
53One carbon pool by folate_Homo sapiens_hsa006700.97425050
54Ribosome_Homo sapiens_hsa030100.97101767
55Starch and sucrose metabolism_Homo sapiens_hsa005000.97057205
56Glycerolipid metabolism_Homo sapiens_hsa005610.94767175
57alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.94186577
58DNA replication_Homo sapiens_hsa030300.92994465
59Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.91952657
60Parkinsons disease_Homo sapiens_hsa050120.89005289
612-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.87212543
62Asthma_Homo sapiens_hsa053100.83909082
63Homologous recombination_Homo sapiens_hsa034400.81476202
64Alzheimers disease_Homo sapiens_hsa050100.79763914
65Collecting duct acid secretion_Homo sapiens_hsa049660.79168744
66Linoleic acid metabolism_Homo sapiens_hsa005910.78093809
67Ether lipid metabolism_Homo sapiens_hsa005650.77620376
68Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.72970372
69Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.72940197
70Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.71343448
71Nucleotide excision repair_Homo sapiens_hsa034200.71284131
72Sulfur relay system_Homo sapiens_hsa041220.70863017
73Biosynthesis of amino acids_Homo sapiens_hsa012300.68307731
74Rheumatoid arthritis_Homo sapiens_hsa053230.62269492
75Maturity onset diabetes of the young_Homo sapiens_hsa049500.61871435
76Type I diabetes mellitus_Homo sapiens_hsa049400.61826445
77ABC transporters_Homo sapiens_hsa020100.60127162
78Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.58906205
79Pyrimidine metabolism_Homo sapiens_hsa002400.57436641
80Vibrio cholerae infection_Homo sapiens_hsa051100.57250780
81Metabolic pathways_Homo sapiens_hsa011000.55736918
82Pentose phosphate pathway_Homo sapiens_hsa000300.54646981
83Prion diseases_Homo sapiens_hsa050200.54519679
84Drug metabolism - other enzymes_Homo sapiens_hsa009830.52878616
85Base excision repair_Homo sapiens_hsa034100.50249096
86Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.49921972
87Lysosome_Homo sapiens_hsa041420.49869441
88Mineral absorption_Homo sapiens_hsa049780.49803318
89Arachidonic acid metabolism_Homo sapiens_hsa005900.48105943
90Folate biosynthesis_Homo sapiens_hsa007900.48060034
91Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.44744684
92Non-homologous end-joining_Homo sapiens_hsa034500.42659837
93Spliceosome_Homo sapiens_hsa030400.42420121
94Adipocytokine signaling pathway_Homo sapiens_hsa049200.42298872
95Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.41243112
96Cysteine and methionine metabolism_Homo sapiens_hsa002700.40463579
97Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.38142713
98Sphingolipid metabolism_Homo sapiens_hsa006000.37873470
99Allograft rejection_Homo sapiens_hsa053300.37859618
100Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.37019729
101Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.36450977
102Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.33481912
103Purine metabolism_Homo sapiens_hsa002300.32705730
104Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.32308125
105Other glycan degradation_Homo sapiens_hsa005110.32296076
106Cyanoamino acid metabolism_Homo sapiens_hsa004600.31625328
107Cardiac muscle contraction_Homo sapiens_hsa042600.30251343
108Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.29897310
109Selenocompound metabolism_Homo sapiens_hsa004500.29621561
110Fructose and mannose metabolism_Homo sapiens_hsa000510.29330657
111Glycerophospholipid metabolism_Homo sapiens_hsa005640.29258616
112Fanconi anemia pathway_Homo sapiens_hsa034600.29189850
113Basal transcription factors_Homo sapiens_hsa030220.28901717
114Renin-angiotensin system_Homo sapiens_hsa046140.27826423
115Gastric acid secretion_Homo sapiens_hsa049710.27759525
116Ovarian steroidogenesis_Homo sapiens_hsa049130.26604367
117Basal cell carcinoma_Homo sapiens_hsa052170.24173852
118Galactose metabolism_Homo sapiens_hsa000520.21587320
119Thyroid hormone synthesis_Homo sapiens_hsa049180.18922997
120Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.16704045
121Hedgehog signaling pathway_Homo sapiens_hsa043400.14921007
122Protein digestion and absorption_Homo sapiens_hsa049740.13144931
123Lysine degradation_Homo sapiens_hsa003100.12476640
124Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.11723522
125Malaria_Homo sapiens_hsa051440.11468015
126ECM-receptor interaction_Homo sapiens_hsa045120.09556132
127GABAergic synapse_Homo sapiens_hsa047270.09121989
128Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.08640330
129Insulin resistance_Homo sapiens_hsa049310.07399739
130Autoimmune thyroid disease_Homo sapiens_hsa053200.02794657

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