ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	fusion of sperm to egg plasma membrane (GO:0007342)	9.22165534
2	sperm capacitation (GO:0048240)	8.49204855
3	microtubule depolymerization (GO:0007019)	8.22463644
4	DNA packaging (GO:0006323)	8.10974028
5	chromosome condensation (GO:0030261)	8.09482023
6	spermatid development (GO:0007286)	7.93971924
7	axonemal dynein complex assembly (GO:0070286)	7.90672783
8	spermatid nucleus differentiation (GO:0007289)	7.45610367
9	single strand break repair (GO:0000012)	7.21800060
10	microtubule polymerization or depolymerization (GO:0031109)	7.10257486
11	plasma membrane fusion (GO:0045026)	7.08395356
12	sperm-egg recognition (GO:0035036)	6.97027082
13	protein polyglutamylation (GO:0018095)	6.94289247
14	centriole replication (GO:0007099)	6.83185114
15	rRNA methylation (GO:0031167)	6.64268146
16	protein targeting to Golgi (GO:0000042)	6.51695935
17	multicellular organism reproduction (GO:0032504)	6.48526342
18	response to pheromone (GO:0019236)	6.41552844
19	binding of sperm to zona pellucida (GO:0007339)	6.41540909
20	establishment of protein localization to Golgi (GO:0072600)	6.27068785
21	epithelial cilium movement (GO:0003351)	6.22098704
22	cilium or flagellum-dependent cell motility (GO:0001539)	6.17948860
23	spermatogenesis (GO:0007283)	6.09759306
24	motile cilium assembly (GO:0044458)	6.08832947
25	regulation of cilium movement (GO:0003352)	6.08810363
26	male gamete generation (GO:0048232)	6.08072477
27	centriole assembly (GO:0098534)	5.97410851
28	retrograde transport, vesicle recycling within Golgi (GO:0000301)	5.95093942
29	reproduction (GO:0000003)	5.90181034
30	negative regulation of inclusion body assembly (GO:0090084)	5.88366542
31	phosphatidylethanolamine biosynthetic process (GO:0006646)	5.70294358
32	rRNA modification (GO:0000154)	5.65429337
33	cell-cell recognition (GO:0009988)	5.65095619
34	gamete generation (GO:0007276)	5.62142552
35	calcium ion-dependent exocytosis (GO:0017156)	5.50692741
36	protein localization to Golgi apparatus (GO:0034067)	5.46632388
37	cilium movement (GO:0003341)	5.37423754
38	phosphatidylethanolamine metabolic process (GO:0046337)	5.30154791
39	sexual reproduction (GO:0019953)	5.19207382
40	single fertilization (GO:0007338)	4.97707963
41	microtubule severing (GO:0051013)	4.95181253
42	seminiferous tubule development (GO:0072520)	4.90150770
43	regulation of centriole replication (GO:0046599)	4.83771051
44	male meiosis I (GO:0007141)	4.80673920
45	germ cell development (GO:0007281)	4.61312862
46	fertilization (GO:0009566)	4.55419518
47	piRNA metabolic process (GO:0034587)	4.49791128
48	multicellular organismal reproductive process (GO:0048609)	4.47062302
49	positive regulation of Rab GTPase activity (GO:0032851)	4.42939488
50	regulation of Rab GTPase activity (GO:0032313)	4.42939488
51	RNA destabilization (GO:0050779)	4.35062988
52	cellular process involved in reproduction in multicellular organism (GO:0022412)	4.34449312
53	regulation of microtubule-based movement (GO:0060632)	4.32233767
54	microtubule nucleation (GO:0007020)	4.20062427
55	nucleus organization (GO:0006997)	4.04634260
56	regulation of inclusion body assembly (GO:0090083)	4.00906465
57	cell wall macromolecule catabolic process (GO:0016998)	3.90861614
58	cellular ketone body metabolic process (GO:0046950)	3.88541551
59	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.82627661
60	meiosis I (GO:0007127)	3.81351240
61	DNA methylation involved in gamete generation (GO:0043046)	3.81285078
62	multicellular organismal movement (GO:0050879)	3.80182847
63	musculoskeletal movement (GO:0050881)	3.80182847
64	chromatin silencing (GO:0006342)	3.78726631
65	regulation of transcription involved in cell fate commitment (GO:0060850)	3.72238962
66	cell wall macromolecule metabolic process (GO:0044036)	3.69208005
67	negative regulation of Rho protein signal transduction (GO:0035024)	3.66368776
68	synapsis (GO:0007129)	3.61921411
69	cerebral cortex neuron differentiation (GO:0021895)	3.61583699
70	chromosome organization involved in meiosis (GO:0070192)	3.59901672
71	histone H3-K9 demethylation (GO:0033169)	3.59519678
72	synaptonemal complex assembly (GO:0007130)	3.57705393
73	male meiosis (GO:0007140)	3.50778216
74	ketone body metabolic process (GO:1902224)	3.37156012
75	axoneme assembly (GO:0035082)	3.34701260
76	polyamine biosynthetic process (GO:0006596)	3.33621696
77	ventricular system development (GO:0021591)	3.33581144
78	synaptonemal complex organization (GO:0070193)	3.12687573
79	meiotic nuclear division (GO:0007126)	3.10590282
80	meiotic cell cycle process (GO:1903046)	3.10120050
81	organic cation transport (GO:0015695)	3.09987409
82	multicellular organismal development (GO:0007275)	3.03937296
83	RNA localization (GO:0006403)	3.02665707
84	protein-DNA complex disassembly (GO:0032986)	3.01069150
85	nucleosome disassembly (GO:0006337)	3.01069150
86	membrane protein intracellular domain proteolysis (GO:0031293)	2.95374367
87	DNA conformation change (GO:0071103)	2.93291968
88	protein depolymerization (GO:0051261)	2.92158186
89	cilium organization (GO:0044782)	2.91650545
90	glomerular visceral epithelial cell development (GO:0072015)	2.90686456
91	spinal cord motor neuron differentiation (GO:0021522)	2.89821343
92	regulation of meiosis I (GO:0060631)	2.88313514
93	cilium assembly (GO:0042384)	2.87519147
94	nuclear pore complex assembly (GO:0051292)	2.86511383
95	intraciliary transport (GO:0042073)	2.82504985
96	glomerular epithelial cell development (GO:0072310)	2.80032626
97	chaperone-mediated protein complex assembly (GO:0051131)	2.78735255
98	homeostasis of number of cells within a tissue (GO:0048873)	2.77342936
99	sperm motility (GO:0030317)	11.2716394
100	acrosome reaction (GO:0007340)	10.3356875

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	5.61555524
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.81423480
3	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	3.49687159
4	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	2.45008347
5	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.45008347
6	EZH2_22144423_ChIP-Seq_EOC_Human	2.36888187
7	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.17241620
8	ELF1_20517297_ChIP-Seq_JURKAT_Human	2.14826861
9	ERA_21632823_ChIP-Seq_H3396_Human	2.14208379
10	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.07517082
11	CBP_20019798_ChIP-Seq_JUKART_Human	2.06281232
12	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	2.06281232
13	YY1_22570637_ChIP-Seq_MALME-3M_Human	2.03833187
14	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.97689724
15	RAC3_21632823_ChIP-Seq_H3396_Human	1.96819671
16	CTCF_27219007_Chip-Seq_Bcells_Human	1.95738249
17	P68_20966046_ChIP-Seq_HELA_Human	1.94336712
18	FUS_26573619_Chip-Seq_HEK293_Human	1.91185527
19	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.91028991
20	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.89753661
21	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.88687127
22	BCL6_27268052_Chip-Seq_Bcells_Human	1.87443739
23	PHF8_20622854_ChIP-Seq_HELA_Human	1.86934359
24	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.85803761
25	E2F1_20622854_ChIP-Seq_HELA_Human	1.85075605
26	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.85054531
27	NANOG_20526341_ChIP-Seq_ESCs_Human	1.84891024
28	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.83660252
29	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.78998194
30	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.78928774
31	BCOR_27268052_Chip-Seq_Bcells_Human	1.75133685
32	TAF2_19829295_ChIP-Seq_ESCs_Human	1.75022669
33	SMC4_20622854_ChIP-Seq_HELA_Human	1.72030270
34	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.70686503
35	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.70226083
36	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.69563503
37	MYC_19829295_ChIP-Seq_ESCs_Human	1.66884089
38	CTCF_20526341_ChIP-Seq_ESCs_Human	1.61163085
39	DROSHA_22980978_ChIP-Seq_HELA_Human	1.58958649
40	ERG_20517297_ChIP-Seq_VCAP_Human	1.54976655
41	ER_23166858_ChIP-Seq_MCF-7_Human	1.52719283
42	OCT4_20526341_ChIP-Seq_ESCs_Human	1.47443035
43	TP63_22573176_ChIP-Seq_HFKS_Human	1.47205517
44	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.47158239
45	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.46240369
46	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.42113161
47	LXR_22292898_ChIP-Seq_THP-1_Human	1.41861278
48	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.40484516
49	ZNF274_21170338_ChIP-Seq_K562_Hela	1.40352519
50	SOX2_22085726_ChIP-Seq_NPCs_Mouse	1.40326484
51	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.36020315
52	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.32508404
53	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.31202820
54	E2F1_17053090_ChIP-ChIP_MCF-7_Human	1.30595007
55	AR_25329375_ChIP-Seq_VCAP_Human	1.29896449
56	P53_21459846_ChIP-Seq_SAOS-2_Human	1.29064257
57	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	1.28791519
58	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.26310796
59	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.24597847
60	P300_27268052_Chip-Seq_Bcells_Human	1.24295935
61	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.21621348
62	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.21351203
63	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.20616378
64	RUNX1_26923725_Chip-Seq_HPCs_Mouse	1.20058547
65	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.17055807
66	CEBPB_22108803_ChIP-Seq_LS180_Human	1.17008665
67	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.15520755
68	RBPJ_21746931_ChIP-Seq_IB4_Human	1.14965223
69	ETV1_20927104_ChIP-Seq_GIST48_Human	1.14736036
70	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.13613738
71	SA1_27219007_Chip-Seq_Bcells_Human	1.13288393
72	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.12429193
73	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.12344357
74	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.11351439
75	CTCF_21964334_Chip-Seq_Bcells_Human	1.10695840
76	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.09144501
77	PKCTHETA_26484144_Chip-Seq_BREAST_Human	1.07700620
78	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	1.06351916
79	NCOR_22424771_ChIP-Seq_293T_Human	1.06218050
80	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.04731202
81	NFYB_21822215_ChIP-Seq_K562_Human	1.04177199
82	OCT4_19829295_ChIP-Seq_ESCs_Human	1.03328153
83	P300_19829295_ChIP-Seq_ESCs_Human	1.02379517
84	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.00497719
85	RUNX2_22187159_ChIP-Seq_PCA_Human	1.00465392
86	SA1_27219007_Chip-Seq_ERYTHROID_Human	0.99161765
87	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.98548125
88	RUNX1_27514584_Chip-Seq_MCF-7_Human	0.98372142
89	HOXB7_26014856_ChIP-Seq_BT474_Human	0.97885233
90	SOX2_21211035_ChIP-Seq_LN229_Human	0.97723443
91	TBL1_22424771_ChIP-Seq_293T_Human	0.97180947
92	AR_21572438_ChIP-Seq_LNCaP_Human	0.97130603
93	RARA_24833708_ChIP-Seq_LIVER_Mouse	0.96826143
94	KLF4_19829295_ChIP-Seq_ESCs_Human	0.96784597
95	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.96379371
96	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.95546866
97	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.95546866
98	PHF8_20622853_ChIP-Seq_HELA_Human	0.95263713
99	REST_21632747_ChIP-Seq_MESCs_Mouse	0.94025199
100	SPI1_20517297_ChIP-Seq_HL60_Human	0.93313905

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005377_hearing/vestibular/ear_phenot	4.38430329
2	MP0003878_abnormal_ear_physiology	4.38430329
3	MP0003698_abnormal_male_reproductive	4.34078765
4	MP0001929_abnormal_gametogenesis	3.94578948
5	MP0005670_abnormal_white_adipose	3.75217847
6	MP0002822_catalepsy	3.74522726
7	MP0005423_abnormal_somatic_nervous	3.71232674
8	MP0001348_abnormal_lacrimal_gland	2.88464673
9	MP0002161_abnormal_fertility/fecundity	2.46695885
10	MP0003718_maternal_effect	2.40707530
11	MP0002210_abnormal_sex_determination	2.38552001
12	MP0000678_abnormal_parathyroid_gland	2.23149368
13	MP0005410_abnormal_fertilization	10.4710636
14	MP0001145_abnormal_male_reproductive	1.82106457
15	MP0002735_abnormal_chemical_nociception	1.76543589
16	MP0003646_muscle_fatigue	1.75610695
17	MP0000653_abnormal_sex_gland	1.69505809
18	MP0005451_abnormal_body_composition	1.64550140
19	MP0002282_abnormal_trachea_morphology	1.59646308
20	MP0001486_abnormal_startle_reflex	1.58407135
21	MP0008877_abnormal_DNA_methylation	1.52288440
22	MP0002249_abnormal_larynx_morphology	1.47531572
23	MP0001485_abnormal_pinna_reflex	1.38761632
24	MP0003136_yellow_coat_color	1.36695363
25	MP0001968_abnormal_touch/_nociception	1.33411285
26	MP0003879_abnormal_hair_cell	1.33122698
27	MP0004742_abnormal_vestibular_system	1.30300112
28	MP0009053_abnormal_anal_canal	1.21704246
29	MP0005171_absent_coat_pigmentation	1.18986546
30	MP0002132_abnormal_respiratory_system	1.13710371
31	MP0001188_hyperpigmentation	1.10957436
32	MP0003011_delayed_dark_adaptation	1.10572508
33	MP0003880_abnormal_central_pattern	1.10307866
34	MP0005551_abnormal_eye_electrophysiolog	1.10259781
35	MP0004859_abnormal_synaptic_plasticity	1.06679617
36	MP0001963_abnormal_hearing_physiology	1.06402535
37	MP0005253_abnormal_eye_physiology	1.05688563
38	MP0000566_synostosis	1.05501133
39	MP0005310_abnormal_salivary_gland	1.05272044
40	MP0002234_abnormal_pharynx_morphology	1.04257020
41	MP0000026_abnormal_inner_ear	1.03189719
42	MP0005666_abnormal_adipose_tissue	1.01285293
43	MP0005248_abnormal_Harderian_gland	1.00096596
44	MP0000534_abnormal_ureter_morphology	0.99934386
45	MP0001529_abnormal_vocalization	0.97115816
46	MP0003077_abnormal_cell_cycle	0.96137466
47	MP0001986_abnormal_taste_sensitivity	0.95237561
48	MP0002067_abnormal_sensory_capabilities	0.92817729
49	MP0000955_abnormal_spinal_cord	0.92299421
50	MP0005379_endocrine/exocrine_gland_phen	0.92274361
51	MP0001765_abnormal_ion_homeostasis	0.89547365
52	MP0005174_abnormal_tail_pigmentation	0.87919615
53	MP0008058_abnormal_DNA_repair	0.86623249
54	MP0005395_other_phenotype	0.85054432
55	MP0000015_abnormal_ear_pigmentation	0.82789618
56	MP0002557_abnormal_social/conspecific_i	0.82419179
57	MP0000049_abnormal_middle_ear	0.81617537
58	MP0002160_abnormal_reproductive_system	0.80115789
59	MP0001905_abnormal_dopamine_level	0.79421583
60	MP0003959_abnormal_lean_body	0.78636966
61	MP0002229_neurodegeneration	0.77429901
62	MP0009745_abnormal_behavioral_response	0.75765713
63	MP0005367_renal/urinary_system_phenotyp	0.75262302
64	MP0000516_abnormal_urinary_system	0.75262302
65	MP0008569_lethality_at_weaning	0.75048620
66	MP0009115_abnormal_fat_cell	0.74182569
67	MP0002272_abnormal_nervous_system	0.73571210
68	MP0002572_abnormal_emotion/affect_behav	0.71990536
69	MP0003693_abnormal_embryo_hatching	0.69021141
70	MP0001970_abnormal_pain_threshold	0.68749640
71	MP0002733_abnormal_thermal_nociception	0.67906482
72	MP0005375_adipose_tissue_phenotype	0.66665345
73	MP0003699_abnormal_female_reproductive	0.66412554
74	MP0008995_early_reproductive_senescence	0.65159936
75	MP0008789_abnormal_olfactory_epithelium	0.62871825
76	MP0009697_abnormal_copulation	0.61074519
77	MP0002928_abnormal_bile_duct	0.60967074
78	MP0000003_abnormal_adipose_tissue	0.60747575
79	MP0004957_abnormal_blastocyst_morpholog	0.60670364
80	MP0002734_abnormal_mechanical_nocicepti	0.60097421
81	MP0005084_abnormal_gallbladder_morpholo	0.59258729
82	MP0009046_muscle_twitch	0.59193002
83	MP0001984_abnormal_olfaction	0.58448995
84	MP0005408_hypopigmentation	0.58391593
85	MP0003137_abnormal_impulse_conducting	0.58348041
86	MP0000778_abnormal_nervous_system	0.58063425
87	MP0001879_abnormal_lymphatic_vessel	0.57303638
88	MP0010307_abnormal_tumor_latency	0.56535285
89	MP0005391_vision/eye_phenotype	0.55283626
90	MP0004085_abnormal_heartbeat	0.55010751
91	MP0002138_abnormal_hepatobiliary_system	0.54709756
92	MP0005083_abnormal_biliary_tract	0.54534100
93	MP0003635_abnormal_synaptic_transmissio	0.53414044
94	MP0002653_abnormal_ependyma_morphology	0.50591929
95	MP0000681_abnormal_thyroid_gland	0.50282040
96	MP0005332_abnormal_amino_acid	0.48343325
97	MP0003861_abnormal_nervous_system	0.47402585
98	MP0002736_abnormal_nociception_after	0.45792441
99	MP0001119_abnormal_female_reproductive	0.44876276
100	MP0010094_abnormal_chromosome_stability	0.44660967

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Dynein arm defect of respiratory motile cilia (HP:0012255)	6.68149799
2	Absent/shortened dynein arms (HP:0200106)	6.68149799
3	Chronic hepatic failure (HP:0100626)	6.16901254
4	Severe visual impairment (HP:0001141)	5.82072445
5	Abnormal respiratory motile cilium physiology (HP:0012261)	5.69332094
6	Tubulointerstitial nephritis (HP:0001970)	5.53235132
7	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	5.45568983
8	Abnormal ciliary motility (HP:0012262)	5.44101001
9	Abnormal respiratory epithelium morphology (HP:0012253)	5.21429799
10	Abnormal respiratory motile cilium morphology (HP:0005938)	5.21429799
11	Attenuation of retinal blood vessels (HP:0007843)	4.92825572
12	Male infertility (HP:0003251)	4.88115808
13	Infertility (HP:0000789)	4.49133637
14	Bony spicule pigmentary retinopathy (HP:0007737)	4.48211624
15	Asymmetric septal hypertrophy (HP:0001670)	4.02830667
16	Cone-rod dystrophy (HP:0000548)	3.96910918
17	Nasal polyposis (HP:0100582)	3.92503424
18	Nephronophthisis (HP:0000090)	3.82630927
19	Rhinitis (HP:0012384)	3.61604336
20	Hyperkalemia (HP:0002153)	3.38613124
21	Resting tremor (HP:0002322)	3.32589697
22	Impulsivity (HP:0100710)	3.09945126
23	Abnormality of macular pigmentation (HP:0008002)	3.09902144
24	Abnormality of the renal medulla (HP:0100957)	3.07287634
25	Abnormality of the nasal mucosa (HP:0000433)	3.03372083
26	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	3.02097717
27	Bell-shaped thorax (HP:0001591)	2.95440555
28	Tubulointerstitial abnormality (HP:0001969)	2.90306628
29	Hypoplasia of the thymus (HP:0000778)	2.89815089
30	Stage 5 chronic kidney disease (HP:0003774)	2.88251821
31	Abnormal spermatogenesis (HP:0008669)	2.85903054
32	Chronic bronchitis (HP:0004469)	2.84049222
33	Progressive cerebellar ataxia (HP:0002073)	2.75126641
34	Polydipsia (HP:0001959)	2.73937510
35	Abnormal drinking behavior (HP:0030082)	2.73937510
36	Enlarged epiphyses (HP:0010580)	2.69142240
37	Aplasia/Hypoplasia of the earlobes (HP:0009906)	2.68882069
38	Facial shape deformation (HP:0011334)	2.68378558
39	Potter facies (HP:0002009)	2.68378558
40	Azoospermia (HP:0000027)	2.60261286
41	Abnormal rod and cone electroretinograms (HP:0008323)	2.58448976
42	Amelogenesis imperfecta (HP:0000705)	2.51779922
43	Abnormality of the costochondral junction (HP:0000919)	2.51665366
44	Bronchiectasis (HP:0002110)	2.46872924
45	Hypoplastic ischia (HP:0003175)	2.45695665
46	Postural instability (HP:0002172)	2.42351081
47	Pancreatic fibrosis (HP:0100732)	2.40157071
48	Abnormal urine output (HP:0012590)	2.39729181
49	Occipital encephalocele (HP:0002085)	2.38770713
50	Abnormality of dental color (HP:0011073)	2.37906141
51	Menstrual irregularities (HP:0000858)	2.35382452
52	Truncal obesity (HP:0001956)	2.32260316
53	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	2.31530349
54	Renovascular hypertension (HP:0100817)	2.30305125
55	Abnormality of the hepatic vasculature (HP:0006707)	2.26260061
56	Myokymia (HP:0002411)	2.23716400
57	Generalized aminoaciduria (HP:0002909)	2.23627217
58	Hypophosphatemic rickets (HP:0004912)	2.23465541
59	Intellectual disability, moderate (HP:0002342)	2.23213773
60	Fetal akinesia sequence (HP:0001989)	2.23181546
61	Progressive sensorineural hearing impairment (HP:0000408)	2.22673700
62	Tubular atrophy (HP:0000092)	2.22111333
63	Decreased central vision (HP:0007663)	2.19689177
64	Renal dysplasia (HP:0000110)	2.19516561
65	Renal Fanconi syndrome (HP:0001994)	2.16209690
66	Hypoalphalipoproteinemia (HP:0003233)	2.11928485
67	Polyuria (HP:0000103)	2.11100840
68	Molar tooth sign on MRI (HP:0002419)	2.10266554
69	Abnormality of midbrain morphology (HP:0002418)	2.10266554
70	Portal hypertension (HP:0001409)	2.09437855
71	Abnormality of the ischium (HP:0003174)	2.06515675
72	Insulin-resistant diabetes mellitus (HP:0000831)	2.03935085
73	Abnormality of renal excretion (HP:0011036)	2.00742149
74	True hermaphroditism (HP:0010459)	1.99871335
75	Short nail (HP:0001799)	1.99820482
76	Pancreatic cysts (HP:0001737)	1.92336220
77	Widely patent fontanelles and sutures (HP:0004492)	1.83722925
78	Horizontal nystagmus (HP:0000666)	1.80105590
79	Type II lissencephaly (HP:0007260)	1.79675955
80	Spontaneous abortion (HP:0005268)	1.76923500
81	Recurrent corneal erosions (HP:0000495)	1.76457929
82	Cystic liver disease (HP:0006706)	1.75930413
83	Congenital hepatic fibrosis (HP:0002612)	1.75413368
84	Hypoalbuminemia (HP:0003073)	1.74884320
85	Abnormal albumin level (HP:0012116)	1.74884320
86	Upper limb muscle weakness (HP:0003484)	1.74301347
87	Failure to thrive in infancy (HP:0001531)	1.72039304
88	Obsessive-compulsive behavior (HP:0000722)	1.70755365
89	Respiratory distress (HP:0002098)	1.69892864
90	Flattened epiphyses (HP:0003071)	1.68789139
91	Abnormality of the aortic arch (HP:0012303)	1.66577595
92	Atonic seizures (HP:0010819)	1.62272207
93	Ventricular tachycardia (HP:0004756)	1.61103902
94	Absent epiphyses (HP:0010577)	1.60246804
95	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	1.60246804
96	Osteomalacia (HP:0002749)	1.59411487
97	Median cleft lip (HP:0000161)	1.59011697
98	Action tremor (HP:0002345)	1.58818704
99	Focal segmental glomerulosclerosis (HP:0000097)	1.58586209
100	Atelectasis (HP:0100750)	1.58444553

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PLK4	8.16361711
2	MAPK15	4.63582087
3	TESK1	4.30438934
4	PNCK	3.93365342
5	BRD4	3.26561305
6	INSRR	3.18764596
7	STK38	3.11589235
8	PLK2	2.91792879
9	DDR2	2.80433398
10	PRKD3	2.51642865
11	STK38L	2.45656716
12	CAMK1G	2.02024849
13	CCNB1	2.00032137
14	MAP4K2	1.86745982
15	DYRK1B	1.80289516
16	WNK1	1.75780701
17	CDK12	1.59964787
18	PTK2B	1.50750301
19	PDPK1	1.47300841
20	NEK6	1.40327978
21	TYRO3	1.35646439
22	WNK4	1.33280301
23	PDK1	1.29332294
24	SIK2	1.24686485
25	PIK3CG	1.21947716
26	KSR2	1.19706345
27	MST1R	1.10149398
28	NTRK3	1.07642636
29	CDK7	1.05461716
30	MAP3K2	1.04460580
31	BRAF	1.00671956
32	MUSK	0.91484453
33	DYRK3	0.91399477
34	BMPR1B	0.85325905
35	STK39	0.80754277
36	MAPK13	0.79502664
37	STK16	0.71349568
38	MARK1	0.69238283
39	CAMK1D	0.67642174
40	PIM2	0.67403045
41	BRSK1	0.64977920
42	LATS2	0.64175540
43	ACVR1B	0.63778731
44	AKT3	0.62456111
45	PKN1	0.60922388
46	TLK1	0.59690236
47	CDK2	0.56003268
48	AURKA	0.55062363
49	MAP2K2	0.54511733
50	RPS6KA2	0.53389942
51	CDK1	0.52724448
52	NEK2	0.51908734
53	PRKG1	0.51280905
54	BLK	0.49749754
55	ARAF	0.47502059
56	ROCK1	0.46317089
57	BRSK2	0.46163770
58	RPS6KA1	0.45871897
59	CHEK1	0.45174830
60	GSK3B	0.44945899
61	MAP3K9	0.44647103
62	WNK3	0.44023255
63	MARK2	0.42826428
64	MTOR	0.41862156
65	CDK19	0.40675565
66	PRKCG	0.37777013
67	MAPK8	0.37705620
68	CDK3	0.36101199
69	CHEK2	0.35961740
70	UHMK1	0.35612001
71	MAP3K7	0.35541239
72	ICK	0.35359030
73	MAPK1	0.34829019
74	SRPK1	0.33625158
75	CAMK1	0.31447241
76	ERBB3	0.31372971
77	MAP3K11	0.31056874
78	SGK223	0.30662062
79	SGK494	0.30662062
80	MARK3	0.30645169
81	ADRBK2	0.30023652
82	PLK1	0.28977608
83	VRK1	0.28848027
84	CDK4	0.28760283
85	SGK1	0.28735017
86	PRKAA2	0.26719835
87	PRKG2	0.25700638
88	MAP3K8	0.25325689
89	MAPK14	0.24478323
90	PRKCZ	0.23056905
91	MET	0.22088668
92	LATS1	0.21910202
93	NEK9	0.21387189
94	CAMK4	0.20733207
95	RPS6KA6	0.19910557
96	TIE1	0.19713582
97	MAP3K4	0.17616353
98	MAP3K10	0.17117490
99	RPS6KC1	0.16686107
100	RPS6KL1	0.16686107

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Fatty acid biosynthesis_Homo sapiens_hsa00061	6.25949461
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	5.82083093
3	Olfactory transduction_Homo sapiens_hsa04740	3.61413923
4	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.96440918
5	RNA transport_Homo sapiens_hsa03013	2.43369624
6	Taste transduction_Homo sapiens_hsa04742	2.26778855
7	Dorso-ventral axis formation_Homo sapiens_hsa04320	2.03341922
8	Butanoate metabolism_Homo sapiens_hsa00650	1.86294198
9	Sulfur relay system_Homo sapiens_hsa04122	1.81404042
10	Fanconi anemia pathway_Homo sapiens_hsa03460	1.67908219
11	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	1.64017515
12	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.61833751
13	Selenocompound metabolism_Homo sapiens_hsa00450	1.61503357
14	Nicotine addiction_Homo sapiens_hsa05033	1.60788464
15	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.59116521
16	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.58193747
17	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.43160670
18	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.42232862
19	Oocyte meiosis_Homo sapiens_hsa04114	1.41566477
20	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.39498202
21	Phototransduction_Homo sapiens_hsa04744	1.38618047
22	Fatty acid metabolism_Homo sapiens_hsa01212	1.36808313
23	Type II diabetes mellitus_Homo sapiens_hsa04930	1.33158583
24	mRNA surveillance pathway_Homo sapiens_hsa03015	1.30991246
25	Phenylalanine metabolism_Homo sapiens_hsa00360	1.27128193
26	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.23342848
27	Steroid biosynthesis_Homo sapiens_hsa00100	1.20584252
28	Fatty acid degradation_Homo sapiens_hsa00071	1.18889016
29	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.18359822
30	Basal transcription factors_Homo sapiens_hsa03022	1.15696779
31	Calcium signaling pathway_Homo sapiens_hsa04020	1.10380207
32	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.08453698
33	Inositol phosphate metabolism_Homo sapiens_hsa00562	1.00778297
34	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.97646510
35	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.96091316
36	cAMP signaling pathway_Homo sapiens_hsa04024	0.95936968
37	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.94776431
38	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.94553072
39	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.91542059
40	Endocytosis_Homo sapiens_hsa04144	0.90760713
41	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.89268275
42	Arginine and proline metabolism_Homo sapiens_hsa00330	0.88072254
43	Salivary secretion_Homo sapiens_hsa04970	0.86171071
44	Fat digestion and absorption_Homo sapiens_hsa04975	0.85786527
45	VEGF signaling pathway_Homo sapiens_hsa04370	0.83457080
46	Base excision repair_Homo sapiens_hsa03410	0.83005993
47	Morphine addiction_Homo sapiens_hsa05032	0.82407893
48	ABC transporters_Homo sapiens_hsa02010	0.81060987
49	Cholinergic synapse_Homo sapiens_hsa04725	0.80452746
50	Glutamatergic synapse_Homo sapiens_hsa04724	0.77421858
51	Estrogen signaling pathway_Homo sapiens_hsa04915	0.77193225
52	Huntingtons disease_Homo sapiens_hsa05016	0.75250767
53	Cardiac muscle contraction_Homo sapiens_hsa04260	0.75086467
54	Homologous recombination_Homo sapiens_hsa03440	0.73529123
55	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.71922284
56	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.69123931
57	Arginine biosynthesis_Homo sapiens_hsa00220	0.66898956
58	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.66824181
59	Purine metabolism_Homo sapiens_hsa00230	0.61502198
60	Protein digestion and absorption_Homo sapiens_hsa04974	0.60953783
61	Circadian entrainment_Homo sapiens_hsa04713	0.60038638
62	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.59272670
63	PPAR signaling pathway_Homo sapiens_hsa03320	0.58866062
64	Glycerolipid metabolism_Homo sapiens_hsa00561	0.58030337
65	Antigen processing and presentation_Homo sapiens_hsa04612	0.57605166
66	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.55916504
67	Nucleotide excision repair_Homo sapiens_hsa03420	0.55839581
68	Cell cycle_Homo sapiens_hsa04110	0.55162306
69	mTOR signaling pathway_Homo sapiens_hsa04150	0.54005619
70	Gastric acid secretion_Homo sapiens_hsa04971	0.52962214
71	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.52623728
72	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.49724470
73	Non-homologous end-joining_Homo sapiens_hsa03450	0.49640076
74	Amphetamine addiction_Homo sapiens_hsa05031	0.48788366
75	Regulation of autophagy_Homo sapiens_hsa04140	0.47350434
76	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.47157454
77	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.44840333
78	Pyrimidine metabolism_Homo sapiens_hsa00240	0.44799908
79	Insulin secretion_Homo sapiens_hsa04911	0.44258494
80	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.43456187
81	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.41587579
82	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.39817754
83	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.38712562
84	Bile secretion_Homo sapiens_hsa04976	0.37802625
85	Serotonergic synapse_Homo sapiens_hsa04726	0.37742879
86	Cocaine addiction_Homo sapiens_hsa05030	0.34957150
87	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.33609022
88	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.33330712
89	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.32788255
90	Metabolic pathways_Homo sapiens_hsa01100	0.31497802
91	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.31470635
92	MAPK signaling pathway_Homo sapiens_hsa04010	0.30907973
93	Long-term potentiation_Homo sapiens_hsa04720	0.30047403
94	Influenza A_Homo sapiens_hsa05164	0.29980945
95	Alcoholism_Homo sapiens_hsa05034	0.26819123
96	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.26405173
97	Prolactin signaling pathway_Homo sapiens_hsa04917	0.25477769
98	GABAergic synapse_Homo sapiens_hsa04727	0.25205253
99	Retinol metabolism_Homo sapiens_hsa00830	0.25063019
100	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.22699052

DBIL5P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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