ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	4.80517790
2	response to pheromone (GO:0019236)	4.49276241
3	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	4.23471259
4	platelet dense granule organization (GO:0060155)	4.21989226
5	behavioral response to nicotine (GO:0035095)	4.20315795
6	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.14552070
7	protein-cofactor linkage (GO:0018065)	4.09655696
8	protein K11-linked deubiquitination (GO:0035871)	3.90277353
9	retinal rod cell development (GO:0046548)	3.75265080
10	regulation of cytokine production involved in inflammatory response (GO:1900015)	3.62670251
11	protein polyglutamylation (GO:0018095)	3.62621093
12	adaptation of signaling pathway (GO:0023058)	3.61703925
13	neural tube formation (GO:0001841)	3.57370382
14	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.54977297
15	regulation of cilium movement (GO:0003352)	3.50795941
16	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	3.50048772
17	establishment of protein localization to Golgi (GO:0072600)	3.45952496
18	retinal cone cell development (GO:0046549)	3.40505531
19	axoneme assembly (GO:0035082)	3.37367451
20	replication fork processing (GO:0031297)	3.37272600
21	piRNA metabolic process (GO:0034587)	3.32837695
22	fucose catabolic process (GO:0019317)	3.29390279
23	L-fucose metabolic process (GO:0042354)	3.29390279
24	L-fucose catabolic process (GO:0042355)	3.29390279
25	DNA double-strand break processing (GO:0000729)	3.26459424
26	protein K6-linked ubiquitination (GO:0085020)	3.25155029
27	signal peptide processing (GO:0006465)	3.21516552
28	cornea development in camera-type eye (GO:0061303)	3.21407381
29	protein targeting to Golgi (GO:0000042)	3.20958503
30	photoreceptor cell development (GO:0042461)	3.16432671
31	S-adenosylmethionine metabolic process (GO:0046500)	3.14793763
32	C4-dicarboxylate transport (GO:0015740)	3.14727981
33	cytochrome complex assembly (GO:0017004)	3.09044534
34	proline transport (GO:0015824)	3.07742073
35	respiratory chain complex IV assembly (GO:0008535)	3.05567876
36	protein localization to cilium (GO:0061512)	3.04741101
37	eye photoreceptor cell development (GO:0042462)	3.03624857
38	cilium morphogenesis (GO:0060271)	2.95523147
39	glycosphingolipid biosynthetic process (GO:0006688)	2.95468267
40	behavioral response to ethanol (GO:0048149)	2.93840186
41	kynurenine metabolic process (GO:0070189)	2.92578882
42	reflex (GO:0060004)	2.90863664
43	regulation of hexokinase activity (GO:1903299)	2.90419716
44	regulation of glucokinase activity (GO:0033131)	2.90419716
45	regulation of hippo signaling (GO:0035330)	2.89632222
46	centriole replication (GO:0007099)	2.89104163
47	head development (GO:0060322)	2.88489331
48	positive regulation of mitochondrial fission (GO:0090141)	2.87814167
49	regulation of alternative mRNA splicing, via spliceosome (GO:0000381)	2.85019492
50	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.84718438
51	glycerophospholipid catabolic process (GO:0046475)	2.83710314
52	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.83222978
53	inositol phosphate catabolic process (GO:0071545)	2.79228708
54	ketone body metabolic process (GO:1902224)	2.78225685
55	preassembly of GPI anchor in ER membrane (GO:0016254)	2.78223322
56	nephron tubule morphogenesis (GO:0072078)	2.75434256
57	nephron epithelium morphogenesis (GO:0072088)	2.75434256
58	cellular ketone body metabolic process (GO:0046950)	2.75127875
59	tryptophan catabolic process (GO:0006569)	2.73957599
60	indole-containing compound catabolic process (GO:0042436)	2.73957599
61	indolalkylamine catabolic process (GO:0046218)	2.73957599
62	amino acid salvage (GO:0043102)	2.72034431
63	L-methionine salvage (GO:0071267)	2.72034431
64	L-methionine biosynthetic process (GO:0071265)	2.72034431
65	detection of light stimulus involved in sensory perception (GO:0050962)	2.71527136
66	detection of light stimulus involved in visual perception (GO:0050908)	2.71527136
67	retrograde transport, vesicle recycling within Golgi (GO:0000301)	2.71465081
68	GPI anchor metabolic process (GO:0006505)	2.71435639
69	nucleobase catabolic process (GO:0046113)	2.70837426
70	alanine transport (GO:0032328)	2.70514950
71	protein complex biogenesis (GO:0070271)	2.70269102
72	DNA methylation involved in gamete generation (GO:0043046)	2.70086060
73	cytidine metabolic process (GO:0046087)	2.69755915
74	cytidine catabolic process (GO:0006216)	2.69755915
75	cytidine deamination (GO:0009972)	2.69755915
76	protein localization to Golgi apparatus (GO:0034067)	2.68756750
77	photoreceptor cell maintenance (GO:0045494)	2.67336729
78	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.64632991
79	somite development (GO:0061053)	2.64381580
80	water-soluble vitamin biosynthetic process (GO:0042364)	2.63228786
81	positive regulation of defense response to virus by host (GO:0002230)	2.62534323
82	cilium organization (GO:0044782)	2.61190120
83	polyol catabolic process (GO:0046174)	2.61104471
84	male meiosis (GO:0007140)	2.60315257
85	indolalkylamine metabolic process (GO:0006586)	2.59683010
86	histone H2A acetylation (GO:0043968)	2.58787526
87	epithelial cilium movement (GO:0003351)	2.58718677
88	transepithelial transport (GO:0070633)	2.57917344
89	peptidyl-histidine modification (GO:0018202)	2.55566187
90	intraciliary transport (GO:0042073)	2.54633115
91	sleep (GO:0030431)	2.53130946
92	pyrimidine nucleobase catabolic process (GO:0006208)	2.52754717
93	protein neddylation (GO:0045116)	2.52666605
94	embryonic epithelial tube formation (GO:0001838)	2.52293667
95	male meiosis I (GO:0007141)	2.51251573
96	postsynaptic membrane organization (GO:0001941)	2.50989504
97	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.50364333
98	regulation of translation, ncRNA-mediated (GO:0045974)	2.50364333
99	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.50364333
100	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.50078577

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.04728601
2	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.21039630
3	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.07831555
4	VDR_22108803_ChIP-Seq_LS180_Human	2.97004804
5	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.84119923
6	IGF1R_20145208_ChIP-Seq_DFB_Human	2.79492015
7	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.71302633
8	GBX2_23144817_ChIP-Seq_PC3_Human	2.67026259
9	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.59285104
10	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.43803012
11	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.20328394
12	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.03151431
13	FUS_26573619_Chip-Seq_HEK293_Human	1.99322006
14	P300_19829295_ChIP-Seq_ESCs_Human	1.99081794
15	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.98187613
16	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.88218923
17	EZH2_22144423_ChIP-Seq_EOC_Human	1.88008052
18	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.86330259
19	ER_23166858_ChIP-Seq_MCF-7_Human	1.85671144
20	BCAT_22108803_ChIP-Seq_LS180_Human	1.80316362
21	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.78574248
22	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.77374584
23	EWS_26573619_Chip-Seq_HEK293_Human	1.76812859
24	TAF15_26573619_Chip-Seq_HEK293_Human	1.74010624
25	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.71324508
26	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.69104200
27	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.68235824
28	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.63721857
29	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.61854330
30	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.61439142
31	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.58265851
32	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.58041724
33	STAT3_23295773_ChIP-Seq_U87_Human	1.55210099
34	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.53647449
35	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.53624575
36	CBP_20019798_ChIP-Seq_JUKART_Human	1.53624575
37	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.50694807
38	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.47592095
39	SMAD4_21799915_ChIP-Seq_A2780_Human	1.47321208
40	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.45765158
41	IRF1_19129219_ChIP-ChIP_H3396_Human	1.45590680
42	TCF4_23295773_ChIP-Seq_U87_Human	1.45343952
43	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.42348066
44	TP53_22573176_ChIP-Seq_HFKS_Human	1.42316096
45	TCF4_22108803_ChIP-Seq_LS180_Human	1.40929626
46	SOX2_19829295_ChIP-Seq_ESCs_Human	1.40590683
47	NANOG_19829295_ChIP-Seq_ESCs_Human	1.40590683
48	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.40210411
49	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.38056042
50	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.37245577
51	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.36639147
52	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.36269504
53	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.34423170
54	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.30681618
55	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.30681618
56	AR_25329375_ChIP-Seq_VCAP_Human	1.29199201
57	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.28021677
58	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.27098834
59	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.26146504
60	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.26062217
61	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.23585589
62	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.22901698
63	P53_22387025_ChIP-Seq_ESCs_Mouse	1.22827979
64	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.20509954
65	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.19203475
66	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.18818730
67	ELK1_19687146_ChIP-ChIP_HELA_Human	1.18374942
68	P300_18555785_Chip-Seq_ESCs_Mouse	1.18014272
69	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.17160171
70	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.16648767
71	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.16580133
72	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.16214117
73	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.15972105
74	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.15816371
75	AR_21572438_ChIP-Seq_LNCaP_Human	1.14932909
76	MYC_18940864_ChIP-ChIP_HL60_Human	1.14913507
77	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.14877963
78	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.14763424
79	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.14605430
80	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.14186729
81	CDX2_22108803_ChIP-Seq_LS180_Human	1.13905349
82	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.12865176
83	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.12278182
84	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.12278182
85	RUNX2_22187159_ChIP-Seq_PCA_Human	1.12183115
86	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.11480011
87	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.11420124
88	NCOR_22424771_ChIP-Seq_293T_Human	1.11199800
89	AR_20517297_ChIP-Seq_VCAP_Human	1.10804244
90	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.10031258
91	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.08918753
92	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.08181873
93	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.06688992
94	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.04030856
95	OCT4_18555785_Chip-Seq_ESCs_Mouse	1.03947575
96	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.03316281
97	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.03245910
98	CTCF_18555785_Chip-Seq_ESCs_Mouse	1.02175105
99	ETV1_20927104_ChIP-Seq_GIST48_Human	1.02074163
100	VDR_23849224_ChIP-Seq_CD4+_Human	1.02046365

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	4.17679418
2	MP0003195_calcinosis	3.21120598
3	MP0003787_abnormal_imprinting	2.75792203
4	MP0006292_abnormal_olfactory_placode	2.38300974
5	MP0002837_dystrophic_cardiac_calcinosis	2.36753325
6	MP0001529_abnormal_vocalization	2.33973763
7	MP0002876_abnormal_thyroid_physiology	2.31842316
8	MP0005646_abnormal_pituitary_gland	2.28536375
9	MP0000569_abnormal_digit_pigmentation	2.27874290
10	MP0006072_abnormal_retinal_apoptosis	2.25721519
11	MP0004885_abnormal_endolymph	2.23980750
12	MP0008875_abnormal_xenobiotic_pharmacok	2.23101564
13	MP0002254_reproductive_system_inflammat	2.20665580
14	MP0005551_abnormal_eye_electrophysiolog	2.19230808
15	MP0000427_abnormal_hair_cycle	2.12656995
16	MP0005645_abnormal_hypothalamus_physiol	2.08410913
17	MP0002736_abnormal_nociception_after	2.05012085
18	MP0005253_abnormal_eye_physiology	2.02537519
19	MP0004147_increased_porphyrin_level	2.01740275
20	MP0003011_delayed_dark_adaptation	1.99033399
21	MP0002102_abnormal_ear_morphology	1.95050494
22	MP0001986_abnormal_taste_sensitivity	1.87052822
23	MP0005075_abnormal_melanosome_morpholog	1.86879059
24	MP0001968_abnormal_touch/_nociception	1.84568490
25	MP0008995_early_reproductive_senescence	1.76382871
26	MP0000372_irregular_coat_pigmentation	1.75045938
27	MP0008872_abnormal_physiological_respon	1.73027211
28	MP0004142_abnormal_muscle_tone	1.71453266
29	MP0003646_muscle_fatigue	1.60767640
30	MP0004043_abnormal_pH_regulation	1.60069503
31	MP0000631_abnormal_neuroendocrine_gland	1.57616927
32	MP0008789_abnormal_olfactory_epithelium	1.53286409
33	MP0001501_abnormal_sleep_pattern	1.48033113
34	MP0009745_abnormal_behavioral_response	1.42052633
35	MP0004133_heterotaxia	1.41091955
36	MP0002095_abnormal_skin_pigmentation	1.40313983
37	MP0003121_genomic_imprinting	1.39071244
38	MP0002277_abnormal_respiratory_mucosa	1.37754351
39	MP0002234_abnormal_pharynx_morphology	1.37180280
40	MP0002933_joint_inflammation	1.36791188
41	MP0003122_maternal_imprinting	1.35490929
42	MP0002272_abnormal_nervous_system	1.30965763
43	MP0003786_premature_aging	1.30236637
44	MP0002653_abnormal_ependyma_morphology	1.30001788
45	MP0009046_muscle_twitch	1.29781878
46	MP0002822_catalepsy	1.26128351
47	MP0006276_abnormal_autonomic_nervous	1.24957394
48	MP0005174_abnormal_tail_pigmentation	1.24716676
49	MP0001486_abnormal_startle_reflex	1.22753321
50	MP0005386_behavior/neurological_phenoty	1.21895964
51	MP0004924_abnormal_behavior	1.21895964
52	MP0003880_abnormal_central_pattern	1.20055752
53	MP0002638_abnormal_pupillary_reflex	1.18959299
54	MP0002557_abnormal_social/conspecific_i	1.15801660
55	MP0000015_abnormal_ear_pigmentation	1.14570719
56	MP0000778_abnormal_nervous_system	1.14279081
57	MP0001984_abnormal_olfaction	1.10259870
58	MP0002163_abnormal_gland_morphology	1.06724955
59	MP0008775_abnormal_heart_ventricle	1.05390810
60	MP0005394_taste/olfaction_phenotype	1.04266495
61	MP0005499_abnormal_olfactory_system	1.04266495
62	MP0001485_abnormal_pinna_reflex	1.03511254
63	MP0001764_abnormal_homeostasis	1.00574484
64	MP0000647_abnormal_sebaceous_gland	1.00381283
65	MP0003136_yellow_coat_color	0.98846976
66	MP0003698_abnormal_male_reproductive	0.98019870
67	MP0005084_abnormal_gallbladder_morpholo	0.97882481
68	MP0001919_abnormal_reproductive_system	0.97738500
69	MP0002751_abnormal_autonomic_nervous	0.97707782
70	MP0005310_abnormal_salivary_gland	0.95495051
71	MP0004215_abnormal_myocardial_fiber	0.93529481
72	MP0002210_abnormal_sex_determination	0.90613665
73	MP0002572_abnormal_emotion/affect_behav	0.87311835
74	MP0003718_maternal_effect	0.87241625
75	MP0005647_abnormal_sex_gland	0.86424135
76	MP0005187_abnormal_penis_morphology	0.85198042
77	MP0005379_endocrine/exocrine_gland_phen	0.83012710
78	MP0004742_abnormal_vestibular_system	0.82586194
79	MP0001929_abnormal_gametogenesis	0.81502446
80	MP0000653_abnormal_sex_gland	0.81199426
81	MP0003635_abnormal_synaptic_transmissio	0.81129600
82	MP0001905_abnormal_dopamine_level	0.81056814
83	MP0002909_abnormal_adrenal_gland	0.80458159
84	MP0000955_abnormal_spinal_cord	0.80227730
85	MP0005195_abnormal_posterior_eye	0.80048289
86	MP0002229_neurodegeneration	0.78937555
87	MP0002063_abnormal_learning/memory/cond	0.77739707
88	MP0009785_altered_susceptibility_to	0.77213911
89	MP0001502_abnormal_circadian_rhythm	0.76837002
90	MP0002752_abnormal_somatic_nervous	0.76395006
91	MP0003119_abnormal_digestive_system	0.76326352
92	MP0005389_reproductive_system_phenotype	0.75778449
93	MP0003045_fibrosis	0.75144455
94	MP0002064_seizures	0.72976170
95	MP0001145_abnormal_male_reproductive	0.71247068
96	MP0002168_other_aberrant_phenotype	0.71225497
97	MP0001970_abnormal_pain_threshold	0.69087984
98	MP0003938_abnormal_ear_development	0.68864859
99	MP0000383_abnormal_hair_follicle	0.68412918
100	MP0005636_abnormal_mineral_homeostasis	0.66621683

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.28436266
2	Pancreatic fibrosis (HP:0100732)	4.12668630
3	True hermaphroditism (HP:0010459)	4.00877421
4	Abnormality of the renal cortex (HP:0011035)	3.61821269
5	Renal cortical cysts (HP:0000803)	3.56643669
6	Nephronophthisis (HP:0000090)	3.52782363
7	Abnormality of midbrain morphology (HP:0002418)	3.49647229
8	Molar tooth sign on MRI (HP:0002419)	3.49647229
9	Medial flaring of the eyebrow (HP:0010747)	3.23958386
10	Congenital stationary night blindness (HP:0007642)	3.23820187
11	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.03236718
12	Abnormal rod and cone electroretinograms (HP:0008323)	2.99027827
13	Hyperventilation (HP:0002883)	2.97047766
14	Chronic hepatic failure (HP:0100626)	2.96075918
15	Abnormality of the renal medulla (HP:0100957)	2.94881705
16	Abolished electroretinogram (ERG) (HP:0000550)	2.91184024
17	Pendular nystagmus (HP:0012043)	2.86918278
18	Intestinal atresia (HP:0011100)	2.83036217
19	Cystic liver disease (HP:0006706)	2.68739364
20	Thyroid-stimulating hormone excess (HP:0002925)	2.64427650
21	Attenuation of retinal blood vessels (HP:0007843)	2.62976336
22	Amyotrophic lateral sclerosis (HP:0007354)	2.60530788
23	Sclerocornea (HP:0000647)	2.56788018
24	Gait imbalance (HP:0002141)	2.46846255
25	Progressive inability to walk (HP:0002505)	2.45601751
26	Abnormality of the labia minora (HP:0012880)	2.44230359
27	Gaze-evoked nystagmus (HP:0000640)	2.42110077
28	Postaxial foot polydactyly (HP:0001830)	2.40901553
29	Congenital primary aphakia (HP:0007707)	2.38771757
30	Nephrogenic diabetes insipidus (HP:0009806)	2.36016939
31	Anencephaly (HP:0002323)	2.33392126
32	Polydipsia (HP:0001959)	2.31640014
33	Abnormal drinking behavior (HP:0030082)	2.31640014
34	Chronic mucocutaneous candidiasis (HP:0002728)	2.29297010
35	Recurrent cutaneous fungal infections (HP:0011370)	2.29297010
36	Neoplasm of the adrenal cortex (HP:0100641)	2.28256727
37	Type II lissencephaly (HP:0007260)	2.24347414
38	Congenital hepatic fibrosis (HP:0002612)	2.22562744
39	Volvulus (HP:0002580)	2.20327084
40	Broad-based gait (HP:0002136)	2.18299328
41	Hypothermia (HP:0002045)	2.15430008
42	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.14389644
43	Genital tract atresia (HP:0001827)	2.13776678
44	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.13660570
45	Acute necrotizing encephalopathy (HP:0006965)	2.08164237
46	Increased CSF lactate (HP:0002490)	2.07904616
47	Tubular atrophy (HP:0000092)	2.05904840
48	Focal seizures (HP:0007359)	2.03762020
49	Disproportionate short-trunk short stature (HP:0003521)	2.02810632
50	Mitochondrial inheritance (HP:0001427)	2.02633814
51	Vaginal atresia (HP:0000148)	2.02146359
52	Hypomagnesemia (HP:0002917)	1.98345617
53	Furrowed tongue (HP:0000221)	1.97771501
54	Pachygyria (HP:0001302)	1.97386314
55	Inability to walk (HP:0002540)	1.97079935
56	Cheilitis (HP:0100825)	1.94819440
57	Postaxial hand polydactyly (HP:0001162)	1.93971251
58	Acute encephalopathy (HP:0006846)	1.93858810
59	Aqueductal stenosis (HP:0002410)	1.93533832
60	Abnormality of macular pigmentation (HP:0008002)	1.92732556
61	Asplenia (HP:0001746)	1.92698066
62	Enlarged kidneys (HP:0000105)	1.92507443
63	Increased corneal curvature (HP:0100692)	1.91920921
64	Keratoconus (HP:0000563)	1.91920921
65	Broad alveolar ridges (HP:0000187)	1.89942963
66	Male pseudohermaphroditism (HP:0000037)	1.89762003
67	Lissencephaly (HP:0001339)	1.89731853
68	Widely spaced teeth (HP:0000687)	1.89174632
69	Progressive macrocephaly (HP:0004481)	1.89080119
70	Median cleft lip (HP:0000161)	1.85362942
71	Cerebellar dysplasia (HP:0007033)	1.84930600
72	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.84649534
73	Methylmalonic aciduria (HP:0012120)	1.80570880
74	Absent speech (HP:0001344)	1.78979750
75	Abnormal respiratory epithelium morphology (HP:0012253)	1.78644332
76	Abnormal respiratory motile cilium morphology (HP:0005938)	1.78644332
77	IgG deficiency (HP:0004315)	1.78640672
78	Astigmatism (HP:0000483)	1.78353664
79	Bony spicule pigmentary retinopathy (HP:0007737)	1.77885391
80	Abnormal biliary tract physiology (HP:0012439)	1.77555843
81	Bile duct proliferation (HP:0001408)	1.77555843
82	Small hand (HP:0200055)	1.76656957
83	Clumsiness (HP:0002312)	1.76121777
84	Methylmalonic acidemia (HP:0002912)	1.72474369
85	Abnormality of the fovea (HP:0000493)	1.72068248
86	Poor coordination (HP:0002370)	1.71967967
87	Oligohydramnios (HP:0001562)	1.71834250
88	Chorioretinal atrophy (HP:0000533)	1.70603816
89	Aplasia/Hypoplasia of the sternum (HP:0006714)	1.68108933
90	Occipital encephalocele (HP:0002085)	1.67216889
91	Lipid accumulation in hepatocytes (HP:0006561)	1.67207016
92	Retinitis pigmentosa (HP:0000510)	1.66675254
93	Pancreatic islet-cell hyperplasia (HP:0004510)	1.66128814
94	Narrow forehead (HP:0000341)	1.65350798
95	Aplasia/hypoplasia of the uterus (HP:0008684)	1.65184751
96	Cutaneous melanoma (HP:0012056)	1.65123662
97	Progressive microcephaly (HP:0000253)	1.64458652
98	Polyuria (HP:0000103)	1.63912168
99	Preaxial hand polydactyly (HP:0001177)	1.62945821
100	Optic disc pallor (HP:0000543)	1.62098010

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.28798006
2	TXK	3.37255949
3	ACVR1B	3.26140499
4	WNK3	3.11756465
5	WNK4	3.02442318
6	PINK1	2.95667985
7	ADRBK2	2.44443575
8	ZAK	2.27603792
9	NUAK1	2.25995717
10	MAP4K2	2.21339197
11	STK39	2.10369887
12	MAPK13	1.96495986
13	BCR	1.79638102
14	OXSR1	1.74720697
15	TRIM28	1.67755168
16	BMPR1B	1.66187050
17	GRK1	1.64158864
18	TLK1	1.61816502
19	CASK	1.60991518
20	MAP3K4	1.54901350
21	ERBB3	1.46914498
22	TAOK3	1.41225539
23	DAPK2	1.39023172
24	WEE1	1.32514589
25	PHKG1	1.29251620
26	PHKG2	1.29251620
27	MST4	1.27001417
28	PAK3	1.20581818
29	AKT3	1.19688696
30	EPHA3	1.18303634
31	CSNK1G2	1.14407113
32	MARK1	1.05944041
33	INSRR	1.02833339
34	IRAK1	1.01047198
35	STK38L	0.99475772
36	NTRK3	0.98373041
37	CSNK1G3	0.92634826
38	PNCK	0.88954181
39	NEK1	0.88497420
40	DYRK2	0.86559240
41	PRKCE	0.83885656
42	PKN1	0.82966705
43	FER	0.81736164
44	MKNK2	0.78547855
45	PRKD3	0.76301685
46	CSNK1A1L	0.75962754
47	CSNK1G1	0.75836470
48	IKBKB	0.74406212
49	MINK1	0.74167021
50	MAPKAPK3	0.73734688
51	PTK2B	0.72672876
52	TNK2	0.72395307
53	PLK3	0.70205203
54	ADRBK1	0.65979051
55	CLK1	0.65297000
56	SIK3	0.65022073
57	VRK1	0.63459733
58	PRKCQ	0.61066178
59	MUSK	0.60978135
60	PLK4	0.59473047
61	MAP2K7	0.59288251
62	SGK2	0.59146362
63	PRKCG	0.59035797
64	LIMK1	0.58153711
65	BRSK2	0.57509953
66	TEC	0.57489511
67	PRKCZ	0.56681661
68	FGFR2	0.54960865
69	PBK	0.54482029
70	ATR	0.54413477
71	CHUK	0.54210069
72	LMTK2	0.53734358
73	SIK2	0.52028184
74	ITK	0.50985873
75	MAP2K2	0.47427843
76	BCKDK	0.46293069
77	FES	0.44544388
78	WNK1	0.42926567
79	EPHB2	0.41703297
80	CSNK1A1	0.41318716
81	EPHA4	0.41223426
82	PLK2	0.41181792
83	STK3	0.40581113
84	STK11	0.40184724
85	MAP2K6	0.40160710
86	SGK223	0.39672356
87	SGK494	0.39672356
88	PRKCH	0.38721982
89	CSNK1D	0.37968908
90	ABL1	0.37470588
91	MKNK1	0.36798697
92	IGF1R	0.35183339
93	PRKACA	0.34675444
94	CAMK2A	0.33936649
95	ATM	0.33809758
96	NTRK2	0.33806820
97	PLK1	0.33270163
98	IKBKE	0.32948073
99	TNIK	0.32797662
100	STK16	0.32399375

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Caffeine metabolism_Homo sapiens_hsa00232	3.49489730
2	Nitrogen metabolism_Homo sapiens_hsa00910	2.70727847
3	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.68603563
4	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.50893918
5	Phototransduction_Homo sapiens_hsa04744	2.48482407
6	Linoleic acid metabolism_Homo sapiens_hsa00591	2.44648546
7	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.39724527
8	Fanconi anemia pathway_Homo sapiens_hsa03460	2.37563131
9	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	2.29895201
10	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.04761189
11	Butanoate metabolism_Homo sapiens_hsa00650	2.04150757
12	Ether lipid metabolism_Homo sapiens_hsa00565	2.04033516
13	Homologous recombination_Homo sapiens_hsa03440	2.00051215
14	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.98554425
15	Selenocompound metabolism_Homo sapiens_hsa00450	1.88633718
16	Oxidative phosphorylation_Homo sapiens_hsa00190	1.87527806
17	Protein export_Homo sapiens_hsa03060	1.86934739
18	Collecting duct acid secretion_Homo sapiens_hsa04966	1.80945682
19	Basal transcription factors_Homo sapiens_hsa03022	1.77077151
20	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.73595037
21	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.65739229
22	ABC transporters_Homo sapiens_hsa02010	1.64833729
23	Propanoate metabolism_Homo sapiens_hsa00640	1.51912033
24	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.49691638
25	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.48389903
26	Nicotine addiction_Homo sapiens_hsa05033	1.45090315
27	Tryptophan metabolism_Homo sapiens_hsa00380	1.43427797
28	Parkinsons disease_Homo sapiens_hsa05012	1.33053257
29	RNA polymerase_Homo sapiens_hsa03020	1.30531881
30	RNA degradation_Homo sapiens_hsa03018	1.26377559
31	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.25097358
32	Peroxisome_Homo sapiens_hsa04146	1.22952164
33	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.18155444
34	One carbon pool by folate_Homo sapiens_hsa00670	1.14048063
35	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.12164682
36	Primary immunodeficiency_Homo sapiens_hsa05340	1.09639600
37	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.09264310
38	Olfactory transduction_Homo sapiens_hsa04740	1.07718994
39	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.06745143
40	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.04832695
41	Taste transduction_Homo sapiens_hsa04742	1.03051881
42	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.01923032
43	Glycerolipid metabolism_Homo sapiens_hsa00561	1.01655036
44	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.01216439
45	Chemical carcinogenesis_Homo sapiens_hsa05204	1.00883198
46	Proteasome_Homo sapiens_hsa03050	0.95138293
47	Retinol metabolism_Homo sapiens_hsa00830	0.95048049
48	Regulation of autophagy_Homo sapiens_hsa04140	0.94095437
49	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.92484634
50	Sulfur metabolism_Homo sapiens_hsa00920	0.88875582
51	Morphine addiction_Homo sapiens_hsa05032	0.87257852
52	Fatty acid elongation_Homo sapiens_hsa00062	0.85473619
53	Insulin secretion_Homo sapiens_hsa04911	0.83806357
54	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.82542400
55	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.82475828
56	Mineral absorption_Homo sapiens_hsa04978	0.81524813
57	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.80672968
58	Circadian rhythm_Homo sapiens_hsa04710	0.80319066
59	Huntingtons disease_Homo sapiens_hsa05016	0.74811629
60	Rheumatoid arthritis_Homo sapiens_hsa05323	0.72739545
61	Circadian entrainment_Homo sapiens_hsa04713	0.72113092
62	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.70645678
63	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.68751471
64	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.68736483
65	GABAergic synapse_Homo sapiens_hsa04727	0.67454572
66	Salivary secretion_Homo sapiens_hsa04970	0.66343549
67	Nucleotide excision repair_Homo sapiens_hsa03420	0.66156399
68	Non-homologous end-joining_Homo sapiens_hsa03450	0.65679321
69	Dopaminergic synapse_Homo sapiens_hsa04728	0.65336291
70	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.64424615
71	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.64289488
72	Serotonergic synapse_Homo sapiens_hsa04726	0.63820354
73	Metabolic pathways_Homo sapiens_hsa01100	0.59628035
74	Fat digestion and absorption_Homo sapiens_hsa04975	0.58841523
75	beta-Alanine metabolism_Homo sapiens_hsa00410	0.57603533
76	Glutamatergic synapse_Homo sapiens_hsa04724	0.56737184
77	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.56658773
78	Antigen processing and presentation_Homo sapiens_hsa04612	0.55372723
79	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.55224617
80	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.55207354
81	Alzheimers disease_Homo sapiens_hsa05010	0.55035384
82	Type I diabetes mellitus_Homo sapiens_hsa04940	0.53731805
83	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.52036648
84	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.51337399
85	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.50864885
86	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.48519965
87	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.47278325
88	Fatty acid degradation_Homo sapiens_hsa00071	0.46228328
89	Fatty acid metabolism_Homo sapiens_hsa01212	0.46114559
90	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.44550345
91	Long-term depression_Homo sapiens_hsa04730	0.42815446
92	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.41556948
93	Arginine and proline metabolism_Homo sapiens_hsa00330	0.41082001
94	Graft-versus-host disease_Homo sapiens_hsa05332	0.40295586
95	Mismatch repair_Homo sapiens_hsa03430	0.39400279
96	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.38875711
97	Cocaine addiction_Homo sapiens_hsa05030	0.36256736
98	Calcium signaling pathway_Homo sapiens_hsa04020	0.35416203
99	Purine metabolism_Homo sapiens_hsa00230	0.34310221
100	Histidine metabolism_Homo sapiens_hsa00340	0.34186162

DBIL5P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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