DBNDD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fatty acid elongation (GO:0030497)7.64991833
2myelination (GO:0042552)6.45232788
3axon ensheathment (GO:0008366)6.44303404
4ensheathment of neurons (GO:0007272)6.44303404
5synaptic vesicle docking involved in exocytosis (GO:0016081)6.39315822
6glutamate secretion (GO:0014047)5.96527469
7long-chain fatty acid biosynthetic process (GO:0042759)5.96419281
8cellular potassium ion homeostasis (GO:0030007)5.91628630
9sodium ion export (GO:0071436)5.63514147
10synaptic vesicle exocytosis (GO:0016079)5.58413266
11membrane depolarization during cardiac muscle cell action potential (GO:0086012)5.48962249
12myelin maintenance (GO:0043217)5.37581303
13regulation of synaptic vesicle exocytosis (GO:2000300)4.96263315
14negative regulation of neurotransmitter transport (GO:0051589)4.86706387
15regulation of short-term neuronal synaptic plasticity (GO:0048172)4.82187416
16cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.81126508
17response to methylmercury (GO:0051597)4.67527526
18negative regulation of neurotransmitter secretion (GO:0046929)4.65782690
19establishment of mitochondrion localization (GO:0051654)4.59623107
20negative regulation of protein localization to cell surface (GO:2000009)4.57197462
21cholesterol biosynthetic process (GO:0006695)4.52762045
22potassium ion homeostasis (GO:0055075)4.49250121
23potassium ion import (GO:0010107)4.42692100
24L-amino acid import (GO:0043092)4.33472315
25regulation of collateral sprouting (GO:0048670)4.30509323
26regulation of synaptic vesicle transport (GO:1902803)4.29355197
27neurotransmitter secretion (GO:0007269)4.23789122
28positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.19593838
29regulation of neuronal synaptic plasticity (GO:0048168)4.18758217
30creatine metabolic process (GO:0006600)4.15747712
31amyloid precursor protein metabolic process (GO:0042982)4.12956951
32regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.11578019
33oligodendrocyte differentiation (GO:0048709)4.08601740
34cell communication by electrical coupling (GO:0010644)4.04499366
35sterol biosynthetic process (GO:0016126)4.03505183
36regulation of cell communication by electrical coupling (GO:0010649)3.95521108
37long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.93665738
38positive regulation of synapse maturation (GO:0090129)3.90671909
39glycerophospholipid catabolic process (GO:0046475)3.89913261
40positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.83149962
41photoreceptor cell differentiation (GO:0046530)3.81633577
42eye photoreceptor cell differentiation (GO:0001754)3.81633577
43locomotory exploration behavior (GO:0035641)3.81321779
44positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.78667068
45presynaptic membrane organization (GO:0097090)3.77179022
46positive regulation of oligodendrocyte differentiation (GO:0048714)3.76465060
47long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.76381143
48apical protein localization (GO:0045176)3.73039666
49positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.69933287
50substantia nigra development (GO:0021762)3.68781080
51cellular sodium ion homeostasis (GO:0006883)3.66795805
52astrocyte development (GO:0014002)3.62291050
53regulation of lipoprotein metabolic process (GO:0050746)3.61160458
54ionotropic glutamate receptor signaling pathway (GO:0035235)3.58962555
55asymmetric protein localization (GO:0008105)3.58717064
56import into cell (GO:0098657)3.56886329
57regulation of long-term neuronal synaptic plasticity (GO:0048169)3.54400340
58detection of calcium ion (GO:0005513)3.53592635
59regulation of voltage-gated calcium channel activity (GO:1901385)3.52438853
60regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.50952461
61isoprenoid biosynthetic process (GO:0008299)3.49991870
62response to redox state (GO:0051775)3.49385351
63vocalization behavior (GO:0071625)3.49323126
64neurotransmitter transport (GO:0006836)3.49072154
65cell communication involved in cardiac conduction (GO:0086065)3.45197262
66neuromuscular process controlling balance (GO:0050885)3.43260978
67acidic amino acid transport (GO:0015800)3.42740441
68regulation of synaptic plasticity (GO:0048167)3.42389592
69fatty-acyl-CoA biosynthetic process (GO:0046949)3.39253949
70postsynaptic membrane organization (GO:0001941)3.39031181
71membrane tubulation (GO:0097320)3.38309200
72adult walking behavior (GO:0007628)3.35610029
73positive regulation of dendritic spine development (GO:0060999)3.33532167
74regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.30286845
75regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.28919780
76presynaptic membrane assembly (GO:0097105)3.28571499
77response to lipoprotein particle (GO:0055094)3.27723965
78regulation of neurotransmitter levels (GO:0001505)3.26425968
79negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.26022340
80fatty-acyl-CoA metabolic process (GO:0035337)3.25953569
81peptidyl-tyrosine autophosphorylation (GO:0038083)3.23963021
82regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.23462936
83neurotransmitter uptake (GO:0001504)3.22484761
84exploration behavior (GO:0035640)3.21847133
85regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.21670577
86amino acid import (GO:0043090)3.20434637
87protein palmitoylation (GO:0018345)3.18925216
88regulation of synapse structural plasticity (GO:0051823)3.18801903
89negative regulation of inclusion body assembly (GO:0090084)3.16949658
90peripheral nervous system axon ensheathment (GO:0032292)3.15196158
91myelination in peripheral nervous system (GO:0022011)3.15196158
92regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.15126782
93synaptic transmission, glutamatergic (GO:0035249)3.14651931
94neuronal action potential propagation (GO:0019227)3.13215191
95very long-chain fatty acid metabolic process (GO:0000038)3.13172439
96regulation of neurotransmitter secretion (GO:0046928)3.12671429
97gamma-aminobutyric acid signaling pathway (GO:0007214)3.11900569
98regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.09555037
99L-glutamate transport (GO:0015813)3.05363370
100regulation of glutamate receptor signaling pathway (GO:1900449)3.04212851
101positive regulation of membrane potential (GO:0045838)3.02427071
102regulation of synapse maturation (GO:0090128)3.01813967
103regulation of excitatory postsynaptic membrane potential (GO:0060079)3.00766531
104axon development (GO:0061564)2.99358841
105long-term synaptic potentiation (GO:0060291)2.99314919
106regulation of dendritic spine morphogenesis (GO:0061001)2.98384354
107cerebellar Purkinje cell layer development (GO:0021680)2.98378962
108neuron cell-cell adhesion (GO:0007158)2.97829596
109negative regulation of axonogenesis (GO:0050771)2.96451073
110protein neddylation (GO:0045116)2.95892275
111magnesium ion transport (GO:0015693)2.95376353
112regulation of dendritic spine development (GO:0060998)2.95257073
113cytoskeletal anchoring at plasma membrane (GO:0007016)2.94175636
114regulation of neurotransmitter transport (GO:0051588)2.91826173
115regulation of ARF protein signal transduction (GO:0032012)2.90548442
116transmission of nerve impulse (GO:0019226)2.89911067
117cerebral cortex radially oriented cell migration (GO:0021799)2.89573555
118neuron-neuron synaptic transmission (GO:0007270)2.89105971
119neurotransmitter-gated ion channel clustering (GO:0072578)2.88853425
120neuron remodeling (GO:0016322)2.87105743
121negative regulation of dendrite morphogenesis (GO:0050774)2.86584632
122cardiac muscle contraction (GO:0060048)2.85707919
123glutamate receptor signaling pathway (GO:0007215)2.85263221
124cerebellar Purkinje cell differentiation (GO:0021702)2.84365301
125regulation of actin filament-based movement (GO:1903115)2.84148150
126glycosylceramide metabolic process (GO:0006677)2.83901779
127GPI anchor biosynthetic process (GO:0006506)2.83403433
128negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.81666479
129long-term memory (GO:0007616)2.80817618
130membrane depolarization during action potential (GO:0086010)2.78671156
131nerve growth factor signaling pathway (GO:0038180)2.78419034
132glycine transport (GO:0015816)2.77128879
133synaptic vesicle endocytosis (GO:0048488)2.75991351
134regulation of cardiac muscle cell contraction (GO:0086004)2.74414099
135limb bud formation (GO:0060174)2.74211979
136regulation of synaptic transmission (GO:0050804)2.74164492
137amyloid precursor protein catabolic process (GO:0042987)2.73573166
138regulation of postsynaptic membrane potential (GO:0060078)2.72657270
139relaxation of smooth muscle (GO:0044557)2.72613533
140GPI anchor metabolic process (GO:0006505)2.72251948
141positive regulation of potassium ion transport (GO:0043268)2.72207364
142positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.71885457
143acyl-CoA biosynthetic process (GO:0071616)2.70249006
144thioester biosynthetic process (GO:0035384)2.70249006
145astrocyte differentiation (GO:0048708)2.69753104
146positive regulation of neurotransmitter secretion (GO:0001956)2.69675110
147detection of temperature stimulus involved in sensory perception (GO:0050961)2.67672902
148detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.67672902
149virion attachment to host cell (GO:0019062)2.61817990
150adhesion of symbiont to host cell (GO:0044650)2.61817990
151iron coordination entity transport (GO:1901678)2.60664334
152peptidyl-cysteine modification (GO:0018198)2.60592622
153peripheral nervous system development (GO:0007422)2.57671685
154regulation of dopamine metabolic process (GO:0042053)2.57515336
155regulation of catecholamine metabolic process (GO:0042069)2.57515336
156neuronal ion channel clustering (GO:0045161)2.55840867
157negative regulation of JUN kinase activity (GO:0043508)2.52949571
158synaptic vesicle maturation (GO:0016188)2.52802926
159enteric nervous system development (GO:0048484)2.52220570
160positive regulation of glial cell differentiation (GO:0045687)2.52080385
161neural nucleus development (GO:0048857)2.48022693
162glial cell development (GO:0021782)2.47272212
163negative regulation of macroautophagy (GO:0016242)2.46983450
164neuron recognition (GO:0008038)2.45604790
165organ growth (GO:0035265)2.44631651
166negative regulation of synaptic transmission, GABAergic (GO:0032229)2.44217200
167negative regulation of execution phase of apoptosis (GO:1900118)2.43400390
168cerebellar granule cell differentiation (GO:0021707)2.43086891
169cellular response to epinephrine stimulus (GO:0071872)2.41865928
170negative regulation of axon extension (GO:0030517)2.41666888
171heme transport (GO:0015886)2.41312456
172Golgi to endosome transport (GO:0006895)2.40960149
173response to lead ion (GO:0010288)2.39852511
174positive regulation of gliogenesis (GO:0014015)2.39018011
175mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.38594776
176preassembly of GPI anchor in ER membrane (GO:0016254)2.36927652
177dendritic spine morphogenesis (GO:0060997)2.36721803
178cellular response to catecholamine stimulus (GO:0071870)2.36316166
179axon ensheathment in central nervous system (GO:0032291)11.6316898
180central nervous system myelination (GO:0022010)11.6316898

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.23964498
2GBX2_23144817_ChIP-Seq_PC3_Human3.17396489
3EZH2_22144423_ChIP-Seq_EOC_Human3.17008709
4EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.64015965
5SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.57623565
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.52662205
7* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.49449674
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.31866285
9SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.19942356
10* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.13807353
11ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.13219956
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.12763961
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.12763961
14TAF15_26573619_Chip-Seq_HEK293_Human2.08843531
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.08135537
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.05459193
17ESR2_21235772_ChIP-Seq_MCF-7_Human2.03717198
18* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.02915243
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.00784083
20OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.00285156
21EED_16625203_ChIP-ChIP_MESCs_Mouse1.98852338
22* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.98430131
23CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.96381456
24AR_21572438_ChIP-Seq_LNCaP_Human1.93484097
25SUZ12_27294783_Chip-Seq_ESCs_Mouse1.91770852
26JARID2_20075857_ChIP-Seq_MESCs_Mouse1.91531082
27EZH2_27294783_Chip-Seq_ESCs_Mouse1.90343550
28ZFP281_18757296_ChIP-ChIP_E14_Mouse1.89006844
29DNAJC2_21179169_ChIP-ChIP_NT2_Human1.84219130
30ZFP57_27257070_Chip-Seq_ESCs_Mouse1.84201719
31VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.84117677
32TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.83710267
33TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.82576896
34DROSHA_22980978_ChIP-Seq_HELA_Human1.72798875
35* KDM2B_26808549_Chip-Seq_K562_Human1.72301539
36ERG_21242973_ChIP-ChIP_JURKAT_Human1.69717849
37* RNF2_27304074_Chip-Seq_ESCs_Mouse1.65255458
38RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.65097631
39LXR_22292898_ChIP-Seq_THP-1_Human1.62414679
40RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.62308489
41CDX2_19796622_ChIP-Seq_MESCs_Mouse1.61753647
42ER_23166858_ChIP-Seq_MCF-7_Human1.60994020
43SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.59312194
44RARB_27405468_Chip-Seq_BRAIN_Mouse1.55241846
45* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.55001915
46IKZF1_21737484_ChIP-ChIP_HCT116_Human1.52481737
47* TET1_21490601_ChIP-Seq_MESCs_Mouse1.52266361
48VDR_22108803_ChIP-Seq_LS180_Human1.48748897
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.44365573
50CBX2_27304074_Chip-Seq_ESCs_Mouse1.43182934
51ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.42901133
52CTBP1_25329375_ChIP-Seq_LNCAP_Human1.42072771
53CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.40955932
54RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.39784829
55PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.39725705
56TRIM28_21343339_ChIP-Seq_HEK293_Human1.39605949
57* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.38166049
58* CTCF_27219007_Chip-Seq_Bcells_Human1.36125546
59STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.34955086
60E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.34846458
61* REST_21632747_ChIP-Seq_MESCs_Mouse1.34767052
62PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.33969795
63TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33082441
64POU3F2_20337985_ChIP-ChIP_501MEL_Human1.32732103
65SRY_22984422_ChIP-ChIP_TESTIS_Rat1.30827340
66PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.29984529
67OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.28930690
68PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.28445518
69CTBP2_25329375_ChIP-Seq_LNCAP_Human1.27879261
70PIAS1_25552417_ChIP-Seq_VCAP_Human1.26620785
71GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24104491
72SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.23937643
73P300_19829295_ChIP-Seq_ESCs_Human1.23576350
74BMI1_23680149_ChIP-Seq_NPCS_Mouse1.23476922
75NRF2_20460467_ChIP-Seq_MEFs_Mouse1.22492972
76NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.22492972
77CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.21880350
78SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.20548421
79LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19555753
80SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.19086081
81KDM2B_26808549_Chip-Seq_SUP-B15_Human1.18741168
82* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.17470342
83NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.17315790
84ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.16656706
85REST_18959480_ChIP-ChIP_MESCs_Mouse1.16311752
86STAT3_23295773_ChIP-Seq_U87_Human1.12465394
87RARG_19884340_ChIP-ChIP_MEFs_Mouse1.09865545
88P53_22127205_ChIP-Seq_FIBROBLAST_Human1.09538395
89EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.08508993
90EP300_21415370_ChIP-Seq_HL-1_Mouse1.08402644
91EOMES_21245162_ChIP-Seq_HESCs_Human1.08210027
92FUS_26573619_Chip-Seq_HEK293_Human1.07033363
93PRDM14_20953172_ChIP-Seq_ESCs_Human1.06079988
94TAL1_26923725_Chip-Seq_HPCs_Mouse1.04435455
95CMYC_18555785_Chip-Seq_ESCs_Mouse1.03611694
96TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03080892
97OCT4_19829295_ChIP-Seq_ESCs_Human1.02434210
98* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.01925309
99CTNNB1_20460455_ChIP-Seq_HCT116_Human1.01728241
100UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01040988
101* SMC4_20622854_ChIP-Seq_HELA_Human1.00957997
102GATA1_26923725_Chip-Seq_HPCs_Mouse1.00728275
103TBX20_22080862_ChIP-Seq_HEART_Mouse1.00530328
104TBX20_22328084_ChIP-Seq_HEART_Mouse1.00530328
105SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.00262046
106* SMAD4_21799915_ChIP-Seq_A2780_Human1.00034647
107PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.99523026
108NANOG_18555785_Chip-Seq_ESCs_Mouse0.99340402
109* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.98294596
110AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.97920971
111MYC_19915707_ChIP-ChIP_AK7_Human0.97286231
112TCF4_23295773_ChIP-Seq_U87_Human0.97211329
113TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.96750890
114MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.96408548
115SOX2_19829295_ChIP-Seq_ESCs_Human0.96360919
116NANOG_19829295_ChIP-Seq_ESCs_Human0.96360919
117SUZ12_18555785_Chip-Seq_ESCs_Mouse0.95801036
118NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95109156
119SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.94514173
120GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.94432561
121HTT_18923047_ChIP-ChIP_STHdh_Human0.94284837
122TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.94142962
123MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93647145
124UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.93406465
125LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93231666
126CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.93006341
127RACK7_27058665_Chip-Seq_MCF-7_Human0.92776389
128P300_18555785_Chip-Seq_ESCs_Mouse0.91739653
129NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.91706534
130NR3C1_23031785_ChIP-Seq_PC12_Mouse0.91643282
131TP53_23651856_ChIP-Seq_MEFs_Mouse0.91418025
132ESR1_21235772_ChIP-Seq_MCF-7_Human0.90933597
133RING1B_27294783_Chip-Seq_ESCs_Mouse0.90469011
134ARNT_22903824_ChIP-Seq_MCF-7_Human0.90291597
135WT1_19549856_ChIP-ChIP_CCG9911_Human0.90261147
136ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.88892965
137SMAD4_21741376_ChIP-Seq_EPCs_Human0.88774945
138RNF2_27304074_Chip-Seq_NSC_Mouse0.88691360
139SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.88275098
140AR_19668381_ChIP-Seq_PC3_Human0.87748206
141MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.87649306
142RING1B_27294783_Chip-Seq_NPCs_Mouse0.86852701
143GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.86758408
144GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.86151475
145SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85993456
146PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.85964863
147SOX2_21211035_ChIP-Seq_LN229_Gbm0.85179290
148DPY_21335234_ChIP-Seq_ESCs_Mouse0.85137895
149SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.84109645
150MITF_21258399_ChIP-Seq_MELANOMA_Human0.82290184
151CREB1_26743006_Chip-Seq_LNCaP_Human0.81907824
152EGR1_19032775_ChIP-ChIP_M12_Human0.81857529
153TET1_21451524_ChIP-Seq_MESCs_Mouse0.79341083
154* P68_20966046_ChIP-Seq_HELA_Human0.78812856
155RAD21_21589869_ChIP-Seq_MESCs_Mouse0.78559089
156* KDM2B_26808549_Chip-Seq_DND41_Human0.77680322
157* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.77420739
158NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.77125700
159EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.76432710
160CTCF_20526341_ChIP-Seq_ESCs_Human0.76222799
161YAP1_20516196_ChIP-Seq_MESCs_Mouse0.76041502

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination5.20561239
2MP0003880_abnormal_central_pattern4.14919815
3MP0003950_abnormal_plasma_membrane3.39748130
4MP0004270_analgesia3.25006663
5MP0003690_abnormal_glial_cell3.06494773
6MP0003329_amyloid_beta_deposits2.93306254
7MP0001529_abnormal_vocalization2.85797950
8MP0002272_abnormal_nervous_system2.73013599
9MP0004859_abnormal_synaptic_plasticity2.70970836
10MP0001486_abnormal_startle_reflex2.59617842
11MP0004885_abnormal_endolymph2.54753833
12MP0005171_absent_coat_pigmentation2.50214192
13MP0001905_abnormal_dopamine_level2.49910322
14MP0004742_abnormal_vestibular_system2.49254562
15MP0002064_seizures2.47995164
16MP0004142_abnormal_muscle_tone2.27844590
17MP0003634_abnormal_glial_cell2.25732066
18MP0003635_abnormal_synaptic_transmissio2.17224342
19MP0005423_abnormal_somatic_nervous2.15296233
20MP0009780_abnormal_chondrocyte_physiolo2.09160886
21MP0009745_abnormal_behavioral_response2.07167058
22MP0003879_abnormal_hair_cell2.04880024
23MP0003136_yellow_coat_color2.04531470
24MP0000778_abnormal_nervous_system2.03614757
25MP0001485_abnormal_pinna_reflex2.03465539
26MP0000751_myopathy1.96746950
27MP0009046_muscle_twitch1.93379169
28MP0005409_darkened_coat_color1.87160837
29MP0005410_abnormal_fertilization1.83476965
30MP0002734_abnormal_mechanical_nocicepti1.83256661
31MP0004043_abnormal_pH_regulation1.80494987
32MP0002229_neurodegeneration1.78884897
33MP0003632_abnormal_nervous_system1.76880019
34MP0002063_abnormal_learning/memory/cond1.68806088
35MP0002572_abnormal_emotion/affect_behav1.65967611
36MP0003631_nervous_system_phenotype1.62954990
37MP0003633_abnormal_nervous_system1.57672333
38MP0001984_abnormal_olfaction1.56347652
39MP0008569_lethality_at_weaning1.54103849
40MP0000604_amyloidosis1.52594826
41MP0001440_abnormal_grooming_behavior1.51726145
42MP0010678_abnormal_skin_adnexa1.49574787
43MP0004215_abnormal_myocardial_fiber1.48720044
44MP0001970_abnormal_pain_threshold1.46682816
45MP0003123_paternal_imprinting1.46124152
46MP0000955_abnormal_spinal_cord1.44795965
47MP0002822_catalepsy1.43635369
48MP0004134_abnormal_chest_morphology1.39542381
49MP0008260_abnormal_autophagy1.39497835
50MP0002882_abnormal_neuron_morphology1.38010238
51MP0005551_abnormal_eye_electrophysiolog1.37788245
52MP0000462_abnormal_digestive_system1.36360092
53MP0002067_abnormal_sensory_capabilities1.33736846
54MP0002066_abnormal_motor_capabilities/c1.32631822
55MP0004381_abnormal_hair_follicle1.28543268
56MP0003806_abnormal_nucleotide_metabolis1.28066117
57MP0001968_abnormal_touch/_nociception1.27345863
58MP0004510_myositis1.26862490
59MP0005386_behavior/neurological_phenoty1.24414405
60MP0004924_abnormal_behavior1.24414405
61MP0000383_abnormal_hair_follicle1.24410831
62MP0002733_abnormal_thermal_nociception1.18225223
63MP0000747_muscle_weakness1.18126721
64MP0005623_abnormal_meninges_morphology1.18011733
65MP0005451_abnormal_body_composition1.15994039
66MP0001963_abnormal_hearing_physiology1.15688459
67MP0003787_abnormal_imprinting1.13344030
68MP0008874_decreased_physiological_sensi1.12153976
69MP0003195_calcinosis1.11538085
70MP0002752_abnormal_somatic_nervous1.06789391
71MP0002736_abnormal_nociception_after1.06452204
72MP0005167_abnormal_blood-brain_barrier1.05637701
73MP0005058_abnormal_lysosome_morphology1.00816010
74MP0004145_abnormal_muscle_electrophysio0.99663280
75MP0001177_atelectasis0.99162807
76MP0001299_abnormal_eye_distance/0.98283918
77MP0001501_abnormal_sleep_pattern0.95720701
78MP0001346_abnormal_lacrimal_gland0.95529129
79MP0005165_increased_susceptibility_to0.91361155
80MP0002735_abnormal_chemical_nociception0.91322546
81MP0000566_synostosis0.91239732
82MP0000647_abnormal_sebaceous_gland0.90061741
83MP0005330_cardiomyopathy0.88597770
84MP0002837_dystrophic_cardiac_calcinosis0.87528781
85MP0004087_abnormal_muscle_fiber0.87150097
86MP0004130_abnormal_muscle_cell0.87145843
87MP0002972_abnormal_cardiac_muscle0.87056021
88MP0005195_abnormal_posterior_eye0.87054535
89MP0002152_abnormal_brain_morphology0.84702056
90MP0005620_abnormal_muscle_contractility0.84586673
91MP0004084_abnormal_cardiac_muscle0.84255723
92MP0002184_abnormal_innervation0.83438493
93MP0002295_abnormal_pulmonary_circulatio0.81400336
94MP0002557_abnormal_social/conspecific_i0.81065469
95MP0001502_abnormal_circadian_rhythm0.78823248
96MP0005166_decreased_susceptibility_to0.77541622
97MP0005535_abnormal_body_temperature0.77163510
98MP0004147_increased_porphyrin_level0.77149797
99MP0001851_eye_inflammation0.76559206
100MP0000762_abnormal_tongue_morphology0.76463103
101MP0004484_altered_response_of0.75371557
102MP0000579_abnormal_nail_morphology0.74681747
103MP0003938_abnormal_ear_development0.74078535
104MP0004036_abnormal_muscle_relaxation0.73440300
105MP0004811_abnormal_neuron_physiology0.72686719
106MP0002269_muscular_atrophy0.72013403
107MP0004085_abnormal_heartbeat0.71025396
108MP0005253_abnormal_eye_physiology0.70759782
109MP0003656_abnormal_erythrocyte_physiolo0.69975468
110MP0000003_abnormal_adipose_tissue0.69619790
111MP0000749_muscle_degeneration0.68820058
112MP0002090_abnormal_vision0.68558892
113MP0009840_abnormal_foam_cell0.68360493
114MP0001661_extended_life_span0.68245137
115MP0000026_abnormal_inner_ear0.68077630
116MP0003137_abnormal_impulse_conducting0.66758382
117MP0005646_abnormal_pituitary_gland0.66303106
118MP0003075_altered_response_to0.65549708
119MP0005645_abnormal_hypothalamus_physiol0.64892900
120MP0000759_abnormal_skeletal_muscle0.64785170
121MP0005670_abnormal_white_adipose0.63931420
122MP0006276_abnormal_autonomic_nervous0.62429121
123MP0006072_abnormal_retinal_apoptosis0.61946646
124MP0005388_respiratory_system_phenotype0.58775270
125MP0002133_abnormal_respiratory_system0.58775270
126MP0002332_abnormal_exercise_endurance0.57937687
127MP0003191_abnormal_cellular_cholesterol0.57105869
128MP0002106_abnormal_muscle_physiology0.56777532
129MP0006036_abnormal_mitochondrial_physio0.55223569
130MP0002069_abnormal_eating/drinking_beha0.54526173
131MP0002638_abnormal_pupillary_reflex0.52120758

Predicted human phenotypes

RankGene SetZ-score
1Neurofibrillary tangles (HP:0002185)6.41653050
2Degeneration of the lateral corticospinal tracts (HP:0002314)6.38423677
3Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)6.38423677
4Abnormality of the corticospinal tract (HP:0002492)4.82429771
5Cerebral inclusion bodies (HP:0100314)4.71047207
6Peripheral hypomyelination (HP:0007182)4.49948545
7Parakeratosis (HP:0001036)4.28639279
8Sensory axonal neuropathy (HP:0003390)4.09970000
9Cerebral hypomyelination (HP:0006808)4.07578436
10Supranuclear gaze palsy (HP:0000605)4.07129330
11Onion bulb formation (HP:0003383)4.02186720
12Diplopia (HP:0000651)4.00206986
13Abnormality of binocular vision (HP:0011514)4.00206986
14Bundle branch block (HP:0011710)3.86911370
15Atonic seizures (HP:0010819)3.84442498
16Febrile seizures (HP:0002373)3.81175145
17Termporal pattern (HP:0011008)3.63459757
18Insidious onset (HP:0003587)3.63459757
19Myokymia (HP:0002411)3.59674959
20Spastic gait (HP:0002064)3.53784744
21Abnormal auditory evoked potentials (HP:0006958)3.51484260
22Dysmetria (HP:0001310)3.39101025
23Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.38949040
24Intention tremor (HP:0002080)3.31239584
25Ankle clonus (HP:0011448)3.24993529
26Scanning speech (HP:0002168)3.13627061
27Increased serum pyruvate (HP:0003542)3.12114126
28Abnormality of glycolysis (HP:0004366)3.12114126
29Leukodystrophy (HP:0002415)3.08676100
30Generalized tonic-clonic seizures (HP:0002069)3.07644054
31Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.04764009
32Sudden death (HP:0001699)3.02600541
33Retinal dysplasia (HP:0007973)3.02547245
34Alacrima (HP:0000522)2.97616450
35Segmental peripheral demyelination/remyelination (HP:0003481)2.94817647
36Visual hallucinations (HP:0002367)2.83986602
37Abnormal eating behavior (HP:0100738)2.81536124
38Slow saccadic eye movements (HP:0000514)2.80570335
39Absence seizures (HP:0002121)2.77781811
40Focal motor seizures (HP:0011153)2.75817000
41EMG: myopathic abnormalities (HP:0003458)2.70170037
42Mutism (HP:0002300)2.69150293
43Pheochromocytoma (HP:0002666)2.67942740
44Postural instability (HP:0002172)2.67717795
45Tetraplegia (HP:0002445)2.67043540
46CNS hypomyelination (HP:0003429)2.66562104
47Heart block (HP:0012722)2.65064080
48Truncal ataxia (HP:0002078)2.60802039
49Abnormal atrioventricular conduction (HP:0005150)2.59042901
50Delusions (HP:0000746)2.59025208
51Rigidity (HP:0002063)2.58605117
52Hypoplastic pelvis (HP:0008839)2.55068153
53Cerebral hemorrhage (HP:0001342)2.54439104
54Ventricular fibrillation (HP:0001663)2.52490279
55Axonal loss (HP:0003447)2.49508355
56Clumsiness (HP:0002312)2.49474821
57Torticollis (HP:0000473)2.49137911
58Dialeptic seizures (HP:0011146)2.47905085
59Anteriorly placed anus (HP:0001545)2.47356917
60Congenital ichthyosiform erythroderma (HP:0007431)2.46614341
61Obstructive sleep apnea (HP:0002870)2.46381267
62Depression (HP:0000716)2.46358034
63Rapidly progressive (HP:0003678)2.43839264
64Thickened helices (HP:0000391)2.42415797
65Lower limb amyotrophy (HP:0007210)2.42368299
66Syncope (HP:0001279)2.41939406
67Exercise-induced muscle cramps (HP:0003710)2.41250603
68Increased circulating renin level (HP:0000848)2.40275587
69Action tremor (HP:0002345)2.38426603
70Morphological abnormality of the inner ear (HP:0011390)2.38230450
71Absent septum pellucidum (HP:0001331)2.37934204
72Stridor (HP:0010307)2.36769163
73Spastic paraparesis (HP:0002313)2.35460402
74Insomnia (HP:0100785)2.35245783
75Neuroendocrine neoplasm (HP:0100634)2.34387785
76Decreased lacrimation (HP:0000633)2.33204914
77Progressive cerebellar ataxia (HP:0002073)2.32128507
78Aplasia involving bones of the upper limbs (HP:0009823)2.31570397
79Aplasia of the phalanges of the hand (HP:0009802)2.31570397
80Aplasia involving bones of the extremities (HP:0009825)2.31570397
81Megalencephaly (HP:0001355)2.30989842
82Split foot (HP:0001839)2.30802289
83Lower limb muscle weakness (HP:0007340)2.30585274
84Foot dorsiflexor weakness (HP:0009027)2.30078122
85Spastic tetraparesis (HP:0001285)2.29337752
86Anxiety (HP:0000739)2.28680069
87Metabolic alkalosis (HP:0200114)2.28366861
88Autoamputation (HP:0001218)2.26544072
89Focal dystonia (HP:0004373)2.25473983
90Abnormality of the periventricular white matter (HP:0002518)2.22830843
91Apathy (HP:0000741)2.22687693
92Muscle fiber inclusion bodies (HP:0100299)2.20358410
93Premature skin wrinkling (HP:0100678)2.19470659
94Nemaline bodies (HP:0003798)2.18322587
95Urinary bladder sphincter dysfunction (HP:0002839)2.15781696
96Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.15726898
97Ventricular arrhythmia (HP:0004308)2.14421230
98Poor speech (HP:0002465)2.13508029
99Bradykinesia (HP:0002067)2.12701833
100Impaired vibration sensation in the lower limbs (HP:0002166)2.10717307
101Exercise-induced myalgia (HP:0003738)2.09561287
102Slow progression (HP:0003677)2.09308695
103Urinary urgency (HP:0000012)2.08077760
104Centrally nucleated skeletal muscle fibers (HP:0003687)2.07845196
105Abnormality of the foot musculature (HP:0001436)2.07778139
106Distal lower limb muscle weakness (HP:0009053)2.07047523
107Atrial fibrillation (HP:0005110)2.06385490
108Hypoplasia of the iris (HP:0007676)2.05744280
109Craniofacial dystonia (HP:0012179)2.05575532
110Clonus (HP:0002169)2.04873101
111Papilledema (HP:0001085)2.04239458
112Hemiparesis (HP:0001269)2.03586599
113Hemiplegia (HP:0002301)2.03042965
114Muscle fiber splitting (HP:0003555)2.02601103
115Akinesia (HP:0002304)2.01904952
116Diminished motivation (HP:0000745)2.01225828
117White forelock (HP:0002211)2.01073741
118Poor eye contact (HP:0000817)2.00802634
119Decreased motor nerve conduction velocity (HP:0003431)2.00506170
120Abnormality of the phalanges of the 2nd finger (HP:0009541)2.00409833
121Primary atrial arrhythmia (HP:0001692)2.00182141
122Sleep apnea (HP:0010535)1.99900738
123Annular pancreas (HP:0001734)1.99755824
124Supraventricular tachycardia (HP:0004755)1.99262687
125Hypokalemic alkalosis (HP:0001949)1.98841724
126Abnormality of the septum pellucidum (HP:0007375)1.98314666
127Patchy hypopigmentation of hair (HP:0011365)1.97503072
128Hepatosplenomegaly (HP:0001433)1.97360314
129Atrioventricular block (HP:0001678)1.96678844
130Status epilepticus (HP:0002133)1.96627355
131Choreoathetosis (HP:0001266)1.96220155
132Coronal craniosynostosis (HP:0004440)1.95616404
133Hypomagnesemia (HP:0002917)1.94485979
134Methylmalonic acidemia (HP:0002912)1.93626088
135Hammertoe (HP:0001765)1.92253264
136Limb dystonia (HP:0002451)1.89637866
137Paraparesis (HP:0002385)1.88994867
138Focal seizures (HP:0007359)1.88326346
139Bowel incontinence (HP:0002607)1.87059452
140Dysdiadochokinesis (HP:0002075)1.84347074
141Morphological abnormality of the pyramidal tract (HP:0002062)1.82848391
142Epileptic encephalopathy (HP:0200134)1.82699506
143Neuronal loss in central nervous system (HP:0002529)1.82684068
144Abnormality of the middle phalanges of the toes (HP:0010183)1.82660747
145Gowers sign (HP:0003391)1.82519343
146Distal sensory impairment (HP:0002936)1.82368164
147Infantile muscular hypotonia (HP:0008947)1.82190327
148Urinary incontinence (HP:0000020)1.81936429
149Humeroradial synostosis (HP:0003041)1.79575899
150Synostosis involving the elbow (HP:0003938)1.79575899
151Esophageal atresia (HP:0002032)1.77740446
152Hypophosphatemic rickets (HP:0004912)1.77373067
153Hyporeflexia of lower limbs (HP:0002600)1.75314533
154Acute necrotizing encephalopathy (HP:0006965)1.75266556
155Vaginal atresia (HP:0000148)1.74997545
156Abnormal large intestine physiology (HP:0012700)1.74584199
157Broad-based gait (HP:0002136)1.72063486
158Peripheral demyelination (HP:0011096)1.71208694

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK395.95720105
2OXSR14.15098658
3EPHB13.43737940
4MAPKAPK53.29709427
5PKN12.73956314
6BCR2.53371051
7PBK2.49925417
8WNK42.42764212
9FGFR22.15249016
10UHMK12.10690304
11CDK192.09030867
12WNK11.98496204
13RIPK11.92391511
14LIMK11.89593374
15MET1.86958720
16PNCK1.82799605
17CAMK2B1.73673642
18CAMKK11.68970431
19TNIK1.68563777
20EPHA41.66754961
21NTRK11.65481774
22CSNK1G31.64858570
23CSNK1A1L1.57850991
24SGK4941.57732137
25SGK2231.57732137
26TESK11.57245825
27LATS21.50793486
28ROCK21.49445097
29NEK61.41053967
30CAMK2D1.38993783
31CASK1.37941845
32TESK21.37377387
33PAK61.32816697
34CSNK1G21.31348580
35MST41.30642102
36OBSCN1.29947343
37DAPK11.29113975
38MAP3K121.27512115
39PRPF4B1.26943853
40CLK11.26187248
41CSNK1G11.23957143
42MARK11.23016715
43FGR1.22382635
44CAMK11.18017541
45CAMK2G1.13638220
46MAPK121.12897091
47LMTK21.09445310
48TYRO31.05782659
49ILK1.00338315
50CAMK2A0.99518528
51DYRK20.97002402
52CDK50.93938947
53MAP3K110.92080817
54ALK0.91721260
55TTN0.91318032
56CDK140.91070754
57MARK20.90414032
58MYLK0.90159587
59PRKD10.88417386
60PRKCG0.88279637
61PHKG10.87309494
62PHKG20.87309494
63MUSK0.84857629
64PDK20.84050669
65KSR20.83678181
66CDK150.82669784
67PAK30.81356769
68ARAF0.80234667
69MAPK100.79471384
70PRKCQ0.78585001
71ICK0.78535008
72CDK180.78265399
73PRKCE0.75095366
74PINK10.74563700
75RIPK40.73995459
76PRKD30.73714234
77BRSK10.73615664
78CDK11A0.73368629
79MAPK150.71425209
80STK380.70332737
81NTRK20.69893569
82BRAF0.69540483
83PDPK10.67458049
84SGK30.65975612
85NTRK30.64061626
86PRKG20.62264810
87MAPK130.62131676
88ROCK10.61714135
89CAMKK20.61006883
90SGK10.60146427
91IRAK20.55006167
92RPS6KA30.54903969
93RPS6KA50.54810400
94BMPR1B0.54616345
95MAP3K90.54585366
96FYN0.53153262
97SGK20.52576963
98MAP3K130.52078635
99MAP3K10.50234313
100MAP3K20.49207204
101CAMK40.49079626
102ABL20.48667382
103PRKCH0.48332814
104PRKG10.47656290
105RAF10.46438266
106MINK10.46222305
107CSNK1A10.46050223
108MAP2K20.45423075
109FES0.45182037
110GRK70.44366372
111CSNK1D0.43757504
112DAPK30.43546915
113PRKACB0.43441256
114PTK20.43195109
115PLK20.42910476
116PRKCZ0.42492610
117SIK20.41838558
118CAMK1G0.41526655
119BMPR20.40924282
120GSK3A0.40576064
121GRK50.39423160
122MAP3K40.39206792
123CCNB10.38639911
124STK110.38518775
125KSR10.37403594
126PRKCA0.37168688
127DAPK20.35598237
128PTK2B0.35230247
129PDK10.35012072
130MAP2K70.34701880
131PRKACA0.33947740
132ADRBK20.33916485
133ERBB40.33764583
134DYRK1A0.32995787
135PAK10.32345335
136DMPK0.30387529
137MKNK10.29443165
138TRPM70.29361716
139PIK3CA0.28457970

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009005.04413999
2Fatty acid elongation_Homo sapiens_hsa000624.26490020
3Steroid biosynthesis_Homo sapiens_hsa001004.22210937
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.17276224
5Ether lipid metabolism_Homo sapiens_hsa005652.92291230
6Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.66240052
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.56565052
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.55901329
9Nitrogen metabolism_Homo sapiens_hsa009102.19464873
10Vitamin B6 metabolism_Homo sapiens_hsa007502.04994633
11Oxidative phosphorylation_Homo sapiens_hsa001902.00252598
12Sulfur metabolism_Homo sapiens_hsa009201.76357258
13Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.71664222
14GABAergic synapse_Homo sapiens_hsa047271.66809350
15Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.61945750
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.61300043
17Glutamatergic synapse_Homo sapiens_hsa047241.60645020
18Histidine metabolism_Homo sapiens_hsa003401.57299911
19Sphingolipid metabolism_Homo sapiens_hsa006001.54393483
20Parkinsons disease_Homo sapiens_hsa050121.52611598
21Linoleic acid metabolism_Homo sapiens_hsa005911.51773796
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.49069118
23Axon guidance_Homo sapiens_hsa043601.48749518
24Alzheimers disease_Homo sapiens_hsa050101.43866815
25alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.39210410
26Serotonergic synapse_Homo sapiens_hsa047261.39122323
27Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.38741193
28Protein export_Homo sapiens_hsa030601.38285712
29Butanoate metabolism_Homo sapiens_hsa006501.35495757
30Morphine addiction_Homo sapiens_hsa050321.32896540
31beta-Alanine metabolism_Homo sapiens_hsa004101.31836367
32Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.29194498
33Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.29061557
34Long-term depression_Homo sapiens_hsa047301.26066103
35Dilated cardiomyopathy_Homo sapiens_hsa054141.21808862
36Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.18235753
37Collecting duct acid secretion_Homo sapiens_hsa049661.17741417
38SNARE interactions in vesicular transport_Homo sapiens_hsa041301.16057081
39GnRH signaling pathway_Homo sapiens_hsa049121.14305942
40Circadian entrainment_Homo sapiens_hsa047131.10568418
41Nicotine addiction_Homo sapiens_hsa050331.09051647
42Cocaine addiction_Homo sapiens_hsa050301.08488840
43cGMP-PKG signaling pathway_Homo sapiens_hsa040221.08376715
44Estrogen signaling pathway_Homo sapiens_hsa049151.06274479
45Synaptic vesicle cycle_Homo sapiens_hsa047211.04891767
46Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.04303152
47Arginine and proline metabolism_Homo sapiens_hsa003301.01202443
48Bile secretion_Homo sapiens_hsa049761.01022276
49Vibrio cholerae infection_Homo sapiens_hsa051100.98980642
50Renal cell carcinoma_Homo sapiens_hsa052110.98749043
51Salivary secretion_Homo sapiens_hsa049700.95913653
52Cardiac muscle contraction_Homo sapiens_hsa042600.93794898
53Sphingolipid signaling pathway_Homo sapiens_hsa040710.92063115
54Dopaminergic synapse_Homo sapiens_hsa047280.91907360
55Arginine biosynthesis_Homo sapiens_hsa002200.91565373
56Gastric acid secretion_Homo sapiens_hsa049710.89983584
57Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.88998865
58Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.86362482
59Thyroid hormone synthesis_Homo sapiens_hsa049180.84467186
60Cholinergic synapse_Homo sapiens_hsa047250.82894758
61Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.82049061
62Circadian rhythm_Homo sapiens_hsa047100.81044375
63Glioma_Homo sapiens_hsa052140.78352350
64Vascular smooth muscle contraction_Homo sapiens_hsa042700.77630661
65Tight junction_Homo sapiens_hsa045300.77622285
66Melanogenesis_Homo sapiens_hsa049160.75673787
67Phototransduction_Homo sapiens_hsa047440.74262838
68Amphetamine addiction_Homo sapiens_hsa050310.73854211
69Glycerophospholipid metabolism_Homo sapiens_hsa005640.73610590
70Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.73491467
71Oocyte meiosis_Homo sapiens_hsa041140.72312694
72Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.70962801
73Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.70822878
74Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.70243658
75Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.69536670
76Glucagon signaling pathway_Homo sapiens_hsa049220.68911518
77Huntingtons disease_Homo sapiens_hsa050160.68818489
78Phospholipase D signaling pathway_Homo sapiens_hsa040720.67638100
79Renin secretion_Homo sapiens_hsa049240.67467116
80Endocytosis_Homo sapiens_hsa041440.66975840
81Olfactory transduction_Homo sapiens_hsa047400.66933745
82Ras signaling pathway_Homo sapiens_hsa040140.66465006
83Fatty acid metabolism_Homo sapiens_hsa012120.66125821
84Arachidonic acid metabolism_Homo sapiens_hsa005900.65817662
85Mineral absorption_Homo sapiens_hsa049780.64538581
86Ovarian steroidogenesis_Homo sapiens_hsa049130.63213352
87Pancreatic secretion_Homo sapiens_hsa049720.62757120
88Taste transduction_Homo sapiens_hsa047420.62116801
89Gap junction_Homo sapiens_hsa045400.61467118
90Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.60490235
91Rheumatoid arthritis_Homo sapiens_hsa053230.59851137
92Inositol phosphate metabolism_Homo sapiens_hsa005620.59270560
93Propanoate metabolism_Homo sapiens_hsa006400.58813872
94Long-term potentiation_Homo sapiens_hsa047200.58374347
95Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.57594129
96Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.56183013
97Dorso-ventral axis formation_Homo sapiens_hsa043200.55125604
98Lysosome_Homo sapiens_hsa041420.53462223
99Rap1 signaling pathway_Homo sapiens_hsa040150.52627567
100Glutathione metabolism_Homo sapiens_hsa004800.50705698
101Folate biosynthesis_Homo sapiens_hsa007900.49833250
102VEGF signaling pathway_Homo sapiens_hsa043700.49641314
103Phenylalanine metabolism_Homo sapiens_hsa003600.49564820
104Carbon metabolism_Homo sapiens_hsa012000.48606488
105Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48428692
106cAMP signaling pathway_Homo sapiens_hsa040240.47757175
107Carbohydrate digestion and absorption_Homo sapiens_hsa049730.47623527
108Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.46976020
109MAPK signaling pathway_Homo sapiens_hsa040100.46155492
110Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.45782873
111Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.45053958
112Neurotrophin signaling pathway_Homo sapiens_hsa047220.44762318
113Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44611034
114ErbB signaling pathway_Homo sapiens_hsa040120.44282984
115Biosynthesis of amino acids_Homo sapiens_hsa012300.43555927
116Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.43497001
117Insulin secretion_Homo sapiens_hsa049110.43342212
118Phagosome_Homo sapiens_hsa041450.43130968
119Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.41883604
120Autoimmune thyroid disease_Homo sapiens_hsa053200.41534677
121Oxytocin signaling pathway_Homo sapiens_hsa049210.39989562
122Fatty acid biosynthesis_Homo sapiens_hsa000610.39694638
123Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.37751060
124Choline metabolism in cancer_Homo sapiens_hsa052310.37040488
125Calcium signaling pathway_Homo sapiens_hsa040200.36549412
126Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.36078637
127Insulin signaling pathway_Homo sapiens_hsa049100.35527335
128Peroxisome_Homo sapiens_hsa041460.35350838
129Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.34803585
130Hedgehog signaling pathway_Homo sapiens_hsa043400.33808300
131Metabolic pathways_Homo sapiens_hsa011000.33571408
132Steroid hormone biosynthesis_Homo sapiens_hsa001400.33403104
133Phosphatidylinositol signaling system_Homo sapiens_hsa040700.32642704
134Prion diseases_Homo sapiens_hsa050200.32049391
135Pyruvate metabolism_Homo sapiens_hsa006200.31835272
136Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.28564355
137AMPK signaling pathway_Homo sapiens_hsa041520.26611083

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