

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | antigen processing and presentation of endogenous peptide antigen (GO:0002483) | 5.98341945 |
| 2 | antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) | 5.98341945 |
| 3 | antigen processing and presentation of endogenous antigen (GO:0019883) | 5.92299127 |
| 4 | positive regulation by symbiont of host defense response (GO:0052509) | 4.63731682 |
| 5 | modulation by symbiont of host defense response (GO:0052031) | 4.63731682 |
| 6 | modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00 | 4.63731682 |
| 7 | modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0 | 4.63731682 |
| 8 | positive regulation by organism of defense response of other organism involved in symbiotic interact | 4.63731682 |
| 9 | modulation by symbiont of host immune response (GO:0052553) | 4.63731682 |
| 10 | positive regulation of gamma-delta T cell activation (GO:0046645) | 4.59387185 |
| 11 | Arp2/3 complex-mediated actin nucleation (GO:0034314) | 4.47422290 |
| 12 | detection of other organism (GO:0098543) | 4.37945807 |
| 13 | detection of bacterium (GO:0016045) | 4.30716868 |
| 14 | response to peptidoglycan (GO:0032494) | 4.19319914 |
| 15 | macrophage activation involved in immune response (GO:0002281) | 4.12781751 |
| 16 | regulation of B cell receptor signaling pathway (GO:0050855) | 3.80375664 |
| 17 | antigen processing and presentation via MHC class Ib (GO:0002475) | 3.77097348 |
| 18 | positive regulation of antigen receptor-mediated signaling pathway (GO:0050857) | 3.72713675 |
| 19 | detection of external biotic stimulus (GO:0098581) | 3.70367133 |
| 20 | ribosomal small subunit assembly (GO:0000028) | 3.55307325 |
| 21 | response to muramyl dipeptide (GO:0032495) | 3.53830516 |
| 22 | regulation of gamma-delta T cell differentiation (GO:0045586) | 3.51781250 |
| 23 | negative regulation of interleukin-12 production (GO:0032695) | 3.51285814 |
| 24 | immunoglobulin mediated immune response (GO:0016064) | 3.45373857 |
| 25 | positive thymic T cell selection (GO:0045059) | 3.43421828 |
| 26 | leukocyte aggregation (GO:0070486) | 3.40789260 |
| 27 | regulation of mast cell degranulation (GO:0043304) | 3.37841010 |
| 28 | viral transcription (GO:0019083) | 3.36993110 |
| 29 | negative regulation of phagocytosis (GO:0050765) | 3.35827697 |
| 30 | B cell receptor signaling pathway (GO:0050853) | 3.33327836 |
| 31 | detection of molecule of bacterial origin (GO:0032490) | 3.33279018 |
| 32 | negative regulation of lymphocyte mediated immunity (GO:0002707) | 3.31865414 |
| 33 | regulation of dendritic cell antigen processing and presentation (GO:0002604) | 3.30824163 |
| 34 | germinal center formation (GO:0002467) | 3.29948597 |
| 35 | NIK/NF-kappaB signaling (GO:0038061) | 3.28554032 |
| 36 | negative thymic T cell selection (GO:0045060) | 3.28509352 |
| 37 | mannose metabolic process (GO:0006013) | 3.26091809 |
| 38 | negative regulation of leukocyte mediated immunity (GO:0002704) | 3.25551847 |
| 39 | regulation of gamma-delta T cell activation (GO:0046643) | 3.22832247 |
| 40 | regulation of myeloid leukocyte mediated immunity (GO:0002886) | 3.21326261 |
| 41 | regulation of B cell differentiation (GO:0045577) | 3.20556309 |
| 42 | detection of biotic stimulus (GO:0009595) | 3.20170883 |
| 43 | regulation of leukocyte degranulation (GO:0043300) | 3.18445414 |
| 44 | translational termination (GO:0006415) | 3.18338215 |
| 45 | myeloid cell activation involved in immune response (GO:0002275) | 3.16487546 |
| 46 | actin nucleation (GO:0045010) | 3.15925710 |
| 47 | positive regulation of B cell differentiation (GO:0045579) | 3.15923134 |
| 48 | response to host immune response (GO:0052572) | 3.15455478 |
| 49 | response to immune response of other organism involved in symbiotic interaction (GO:0052564) | 3.15455478 |
| 50 | response to type I interferon (GO:0034340) | 3.15110490 |
| 51 | negative T cell selection (GO:0043383) | 3.14949040 |
| 52 | type I interferon signaling pathway (GO:0060337) | 3.14817341 |
| 53 | cellular response to type I interferon (GO:0071357) | 3.14817341 |
| 54 | regulation of antigen processing and presentation of peptide antigen (GO:0002583) | 3.14395758 |
| 55 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 3.10590694 |
| 56 | regulation of type I interferon-mediated signaling pathway (GO:0060338) | 3.08406253 |
| 57 | B cell mediated immunity (GO:0019724) | 3.07922465 |
| 58 | response to host (GO:0075136) | 3.04415238 |
| 59 | response to host defenses (GO:0052200) | 3.04415238 |
| 60 | response to defenses of other organism involved in symbiotic interaction (GO:0052173) | 3.04415238 |
| 61 | negative regulation of leukocyte mediated cytotoxicity (GO:0001911) | 3.04201527 |
| 62 | negative regulation of cell killing (GO:0031342) | 3.04201527 |
| 63 | regulation of mast cell activation involved in immune response (GO:0033006) | 3.03051643 |
| 64 | positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770) | 3.02892147 |
| 65 | tolerance induction (GO:0002507) | 3.01898042 |
| 66 | positive regulation of type I interferon-mediated signaling pathway (GO:0060340) | 3.01581079 |
| 67 | positive regulation of lamellipodium assembly (GO:0010592) | 3.01159992 |
| 68 | granulocyte activation (GO:0036230) | 3.00732012 |
| 69 | thymic T cell selection (GO:0045061) | 2.96155709 |
| 70 | negative regulation of T cell mediated immunity (GO:0002710) | 2.93900498 |
| 71 | macrophage activation (GO:0042116) | 2.93273966 |
| 72 | translational elongation (GO:0006414) | 2.90524309 |
| 73 | interferon-gamma-mediated signaling pathway (GO:0060333) | 2.90345001 |
| 74 | positive regulation of cellular amide metabolic process (GO:0034250) | 2.89710278 |
| 75 | lipopolysaccharide-mediated signaling pathway (GO:0031663) | 2.88090210 |
| 76 | positive regulation of interferon-alpha production (GO:0032727) | 2.87627384 |
| 77 | cellular response to zinc ion (GO:0071294) | 2.85408300 |
| 78 | regulation of T-helper 2 cell differentiation (GO:0045628) | 2.82171923 |
| 79 | response to interleukin-15 (GO:0070672) | 2.81766230 |
| 80 | sequestering of actin monomers (GO:0042989) | 2.81219406 |
| 81 | microglial cell activation (GO:0001774) | 2.80865191 |
| 82 | regulation of protein heterodimerization activity (GO:0043497) | 2.78592902 |
| 83 | negative regulation of innate immune response (GO:0045824) | 2.77316989 |
| 84 | positive regulation of mast cell activation (GO:0033005) | 2.76021097 |
| 85 | regulation of response to interferon-gamma (GO:0060330) | 2.75999902 |
| 86 | regulation of mast cell activation (GO:0033003) | 2.75869553 |
| 87 | T cell migration (GO:0072678) | 2.74879840 |
| 88 | positive regulation of antigen processing and presentation (GO:0002579) | 2.74590851 |
| 89 | regulation of tolerance induction (GO:0002643) | 2.73688516 |
| 90 | barbed-end actin filament capping (GO:0051016) | 2.72546110 |
| 91 | respiratory burst (GO:0045730) | 2.72454161 |
| 92 | regulation of interferon-alpha production (GO:0032647) | 2.72422757 |
| 93 | neutrophil activation involved in immune response (GO:0002283) | 2.71948490 |
| 94 | positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557) | 2.71335437 |
| 95 | regulation of interleukin-12 biosynthetic process (GO:0045075) | 2.69437044 |
| 96 | regulation of interferon-gamma-mediated signaling pathway (GO:0060334) | 2.69128070 |
| 97 | negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515) | 2.68345257 |
| 98 | positive regulation of tumor necrosis factor biosynthetic process (GO:0042535) | 2.67887167 |
| 99 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 2.66764606 |
| 100 | positive regulation of interleukin-2 biosynthetic process (GO:0045086) | 2.66038639 |
| 101 | T cell selection (GO:0045058) | 2.65473113 |
| 102 | production of molecular mediator involved in inflammatory response (GO:0002532) | 2.65395836 |
| 103 | JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397) | 2.64914096 |
| 104 | viral life cycle (GO:0019058) | 2.64496507 |
| 105 | maturation of SSU-rRNA (GO:0030490) | 2.64421274 |
| 106 | negative regulation of type 2 immune response (GO:0002829) | 2.64134682 |
| 107 | regulation of necroptotic process (GO:0060544) | 2.64126847 |
| 108 | positive regulation of lamellipodium organization (GO:1902745) | 2.62996039 |
| 109 | defense response to protozoan (GO:0042832) | 2.62953555 |
| 110 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 2.62852430 |
| 111 | cellular response to interferon-beta (GO:0035458) | 2.62736924 |
| 112 | formation of translation preinitiation complex (GO:0001731) | 2.62543097 |
| 113 | natural killer cell differentiation (GO:0001779) | 2.60571283 |
| 114 | myeloid dendritic cell activation (GO:0001773) | 2.60125634 |
| 115 | regulation of antigen receptor-mediated signaling pathway (GO:0050854) | 2.59539492 |
| 116 | negative regulation of cytokine production involved in immune response (GO:0002719) | 2.59001835 |
| 117 | translational initiation (GO:0006413) | 2.58878598 |
| 118 | leukocyte cell-cell adhesion (GO:0007159) | 2.58853061 |
| 119 | negative regulation of interleukin-6 production (GO:0032715) | 2.57296880 |
| 120 | protein targeting to ER (GO:0045047) | 2.57149772 |
| 121 | T-helper 1 type immune response (GO:0042088) | 2.56983706 |
| 122 | positive regulation of isotype switching (GO:0045830) | 2.56287496 |
| 123 | 3-UTR-mediated mRNA stabilization (GO:0070935) | 2.56171366 |
| 124 | cellular extravasation (GO:0045123) | 2.55833739 |
| 125 | regulation of antigen processing and presentation (GO:0002577) | 2.55713228 |
| 126 | regulation of interferon-beta biosynthetic process (GO:0045357) | 2.55262091 |
| 127 | ribosomal small subunit biogenesis (GO:0042274) | 2.55239765 |
| 128 | cotranslational protein targeting to membrane (GO:0006613) | 2.53859931 |
| 129 | response to protozoan (GO:0001562) | 2.53492147 |
| 130 | DNA strand elongation involved in DNA replication (GO:0006271) | 2.52817662 |
| 131 | negative regulation of erythrocyte differentiation (GO:0045647) | 2.51391508 |
| 132 | regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923) | 2.50665807 |
| 133 | T cell apoptotic process (GO:0070231) | 2.49052343 |
| 134 | T cell costimulation (GO:0031295) | 2.48448241 |
| 135 | hepatocyte apoptotic process (GO:0097284) | 2.47578195 |
| 136 | response to interferon-beta (GO:0035456) | 2.46339321 |
| 137 | negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665) | 2.46159148 |
| 138 | antigen receptor-mediated signaling pathway (GO:0050851) | 2.45604588 |
| 139 | cellular protein complex disassembly (GO:0043624) | 2.45390267 |
| 140 | lymphocyte costimulation (GO:0031294) | 2.44072968 |
| 141 | DNA strand elongation (GO:0022616) | 2.43640836 |
| 142 | DNA unwinding involved in DNA replication (GO:0006268) | 2.43218017 |
| 143 | telomere maintenance via semi-conservative replication (GO:0032201) | 2.42907373 |
| 144 | positive T cell selection (GO:0043368) | 2.42889948 |
| 145 | mature B cell differentiation (GO:0002335) | 2.42641968 |
| 146 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 2.42523794 |
| 147 | cellular response to interleukin-15 (GO:0071350) | 2.42329079 |
| 148 | neutrophil activation (GO:0042119) | 2.39575224 |
| 149 | regulation of alpha-beta T cell proliferation (GO:0046640) | 2.39315122 |
| 150 | regulation of T cell tolerance induction (GO:0002664) | 2.39278666 |
| 151 | protein localization to endoplasmic reticulum (GO:0070972) | 2.38667699 |
| 152 | T cell homeostasis (GO:0043029) | 2.38251654 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 5.00177601 |
| 2 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 3.66175957 |
| 3 | MYC_22102868_ChIP-Seq_BL_Human | 3.18572989 |
| 4 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 3.06480085 |
| 5 | * EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.05130871 |
| 6 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 2.95877855 |
| 7 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 2.74096130 |
| 8 | VDR_21846776_ChIP-Seq_THP-1_Human | 2.66313181 |
| 9 | * MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 2.57783228 |
| 10 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 2.52891129 |
| 11 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 2.51632314 |
| 12 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 2.34319302 |
| 13 | * SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 2.24935651 |
| 14 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 2.19607115 |
| 15 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 2.14893169 |
| 16 | MAF_26560356_Chip-Seq_TH1_Human | 2.12827176 |
| 17 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 2.02679018 |
| 18 | * MYC_18555785_ChIP-Seq_MESCs_Mouse | 1.97381583 |
| 19 | SPI1_23547873_ChIP-Seq_NB4_Human | 1.95740044 |
| 20 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 1.93803876 |
| 21 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 1.93215445 |
| 22 | MYB_26560356_Chip-Seq_TH2_Human | 1.92386527 |
| 23 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.92061749 |
| 24 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 1.91224659 |
| 25 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 1.90703777 |
| 26 | UTX_26944678_Chip-Seq_JUKART_Human | 1.88696450 |
| 27 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.88691057 |
| 28 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 1.83981195 |
| 29 | * TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.81695425 |
| 30 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 1.81233778 |
| 31 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.80862566 |
| 32 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 1.80654695 |
| 33 | * FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.79899671 |
| 34 | * VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.79226819 |
| 35 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 1.76880626 |
| 36 | * NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.76841844 |
| 37 | * VDR_24763502_ChIP-Seq_THP-1_Human | 1.72978200 |
| 38 | MYB_26560356_Chip-Seq_TH1_Human | 1.69605864 |
| 39 | TCF7_22412390_ChIP-Seq_EML_Mouse | 1.69469501 |
| 40 | * SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.67174665 |
| 41 | * RUNX1_22412390_ChIP-Seq_EML_Mouse | 1.65666251 |
| 42 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 1.64976963 |
| 43 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 1.62228495 |
| 44 | * BRD4_27068464_Chip-Seq_AML-cells_Mouse | 1.62183568 |
| 45 | SCL_19346495_ChIP-Seq_HPC-7_Human | 1.61807549 |
| 46 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.61482413 |
| 47 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 1.59523967 |
| 48 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 1.58684510 |
| 49 | * SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.58325008 |
| 50 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.55491954 |
| 51 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.54942380 |
| 52 | RACK7_27058665_Chip-Seq_MCF-7_Human | 1.54504008 |
| 53 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.53522964 |
| 54 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.52125929 |
| 55 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.51319518 |
| 56 | MAF_26560356_Chip-Seq_TH2_Human | 1.48621391 |
| 57 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.47532047 |
| 58 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 1.44662580 |
| 59 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 1.43959163 |
| 60 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.41801349 |
| 61 | * PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.41790471 |
| 62 | CTCF_27219007_Chip-Seq_ERYTHROID_Human | 1.41045626 |
| 63 | KDM2B_26808549_Chip-Seq_JURKAT_Human | 1.39744798 |
| 64 | * BCOR_27268052_Chip-Seq_Bcells_Human | 1.39188526 |
| 65 | KDM2B_26808549_Chip-Seq_DND41_Human | 1.38703094 |
| 66 | KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 1.36423947 |
| 67 | P68_20966046_ChIP-Seq_HELA_Human | 1.31711253 |
| 68 | SPI1_23127762_ChIP-Seq_K562_Human | 1.29977064 |
| 69 | VDR_23849224_ChIP-Seq_CD4+_Human | 1.29731875 |
| 70 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 1.29669480 |
| 71 | TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 1.29435022 |
| 72 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.28008341 |
| 73 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.26784465 |
| 74 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 1.26494817 |
| 75 | * GABP_17652178_ChIP-ChIP_JURKAT_Human | 1.26186970 |
| 76 | SA1_27219007_Chip-Seq_ERYTHROID_Human | 1.26184613 |
| 77 | * PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.25754091 |
| 78 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.25327834 |
| 79 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 1.24253716 |
| 80 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 1.23244298 |
| 81 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 1.22735905 |
| 82 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.22028831 |
| 83 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 1.21728602 |
| 84 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 1.21454326 |
| 85 | RUNX_20019798_ChIP-Seq_JUKART_Human | 1.19909970 |
| 86 | * LXR_22292898_ChIP-Seq_THP-1_Human | 1.19807650 |
| 87 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.18857044 |
| 88 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.16743832 |
| 89 | GATA1_19941826_ChIP-Seq_K562_Human | 1.16169090 |
| 90 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.15669986 |
| 91 | * GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 1.14789189 |
| 92 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 1.14348838 |
| 93 | SMC4_20622854_ChIP-Seq_HELA_Human | 1.14205918 |
| 94 | * NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.13624391 |
| 95 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.12988848 |
| 96 | KDM2B_26808549_Chip-Seq_K562_Human | 1.12786673 |
| 97 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.12338550 |
| 98 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.12014900 |
| 99 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.10553929 |
| 100 | * SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.09415330 |
| 101 | * GABP_19822575_ChIP-Seq_HepG2_Human | 1.09042709 |
| 102 | CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.08697688 |
| 103 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 1.08434547 |
| 104 | * GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 1.08143308 |
| 105 | * JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 1.07804885 |
| 106 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.07256609 |
| 107 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.05812960 |
| 108 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 1.05804610 |
| 109 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.05579249 |
| 110 | * CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.04492518 |
| 111 | * TET1_21451524_ChIP-Seq_MESCs_Mouse | 1.04152352 |
| 112 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.02308159 |
| 113 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 1.02048243 |
| 114 | * EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 1.00250688 |
| 115 | * BCL6_27268052_Chip-Seq_Bcells_Human | 0.99889244 |
| 116 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 0.99820504 |
| 117 | * PU_27001747_Chip-Seq_BMDM_Mouse | 0.99669935 |
| 118 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 0.99482937 |
| 119 | GATA3_27048872_Chip-Seq_THYMUS_Human | 0.99062664 |
| 120 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 0.98735110 |
| 121 | KDM5A_27292631_Chip-Seq_BREAST_Human | 0.98387274 |
| 122 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 0.98305992 |
| 123 | CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.98305284 |
| 124 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 0.97308527 |
| 125 | SMAD2/3_21741376_ChIP-Seq_ESCs_Human | 0.97195027 |
| 126 | NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human | 0.96905509 |
| 127 | GATA2_21666600_ChIP-Seq_HMVEC_Human | 0.96512331 |
| 128 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 0.96501099 |
| 129 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 0.96102529 |
| 130 | * DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 0.95804966 |
| 131 | * CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.95500822 |
| 132 | * PU.1_20513432_ChIP-Seq_Bcells_Mouse | 0.94965237 |
| 133 | * VDR_24787735_ChIP-Seq_THP-1_Human | 0.94944094 |
| 134 | NCOR1_26117541_ChIP-Seq_K562_Human | 0.94625715 |
| 135 | KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.93478359 |
| 136 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 0.93475046 |
| 137 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 0.93330406 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0001835_abnormal_antigen_presentation | 3.86523006 |
| 2 | MP0000685_abnormal_immune_system | 3.20536850 |
| 3 | MP0003303_peritoneal_inflammation | 2.83493592 |
| 4 | * MP0001800_abnormal_humoral_immune | 2.81840122 |
| 5 | MP0005671_abnormal_response_to | 2.80802114 |
| 6 | MP0003436_decreased_susceptibility_to | 2.76367085 |
| 7 | MP0001790_abnormal_immune_system | 2.72401114 |
| 8 | MP0005387_immune_system_phenotype | 2.72401114 |
| 9 | MP0009785_altered_susceptibility_to | 2.63374238 |
| 10 | MP0005000_abnormal_immune_tolerance | 2.58798528 |
| 11 | MP0003763_abnormal_thymus_physiology | 2.57557667 |
| 12 | * MP0002452_abnormal_antigen_presenting | 2.54329925 |
| 13 | MP0002396_abnormal_hematopoietic_system | 2.48740789 |
| 14 | MP0005025_abnormal_response_to | 2.44550086 |
| 15 | * MP0002420_abnormal_adaptive_immunity | 2.39355896 |
| 16 | * MP0001819_abnormal_immune_cell | 2.38520932 |
| 17 | * MP0002723_abnormal_immune_serum | 2.36199043 |
| 18 | * MP0002398_abnormal_bone_marrow | 2.35644356 |
| 19 | MP0002148_abnormal_hypersensitivity_rea | 2.26884170 |
| 20 | MP0008260_abnormal_autophagy | 2.24937250 |
| 21 | MP0009333_abnormal_splenocyte_physiolog | 2.13380388 |
| 22 | MP0010352_gastrointestinal_tract_polyps | 2.07607243 |
| 23 | * MP0000716_abnormal_immune_system | 2.06387498 |
| 24 | MP0004947_skin_inflammation | 2.03501879 |
| 25 | MP0002419_abnormal_innate_immunity | 2.02821408 |
| 26 | MP0002405_respiratory_system_inflammati | 1.98578403 |
| 27 | * MP0000689_abnormal_spleen_morphology | 1.93544428 |
| 28 | MP0002166_altered_tumor_susceptibility | 1.93321203 |
| 29 | MP0003300_gastrointestinal_ulcer | 1.92904508 |
| 30 | * MP0002722_abnormal_immune_system | 1.92573169 |
| 31 | MP0010155_abnormal_intestine_physiology | 1.92000342 |
| 32 | MP0003693_abnormal_embryo_hatching | 1.91648871 |
| 33 | MP0004808_abnormal_hematopoietic_stem | 1.83622767 |
| 34 | * MP0002429_abnormal_blood_cell | 1.83533868 |
| 35 | MP0005464_abnormal_platelet_physiology | 1.83113825 |
| 36 | MP0004510_myositis | 1.81381477 |
| 37 | MP0005451_abnormal_body_composition | 1.74430707 |
| 38 | MP0000858_altered_metastatic_potential | 1.70932767 |
| 39 | MP0005397_hematopoietic_system_phenotyp | 1.69722459 |
| 40 | MP0001545_abnormal_hematopoietic_system | 1.69722459 |
| 41 | MP0000490_abnormal_crypts_of | 1.69308171 |
| 42 | MP0000703_abnormal_thymus_morphology | 1.67446472 |
| 43 | MP0009278_abnormal_bone_marrow | 1.66370946 |
| 44 | MP0001873_stomach_inflammation | 1.63435026 |
| 45 | MP0006082_CNS_inflammation | 1.60534332 |
| 46 | MP0001845_abnormal_inflammatory_respons | 1.59528913 |
| 47 | MP0001853_heart_inflammation | 1.58957381 |
| 48 | MP0002006_tumorigenesis | 1.58663067 |
| 49 | MP0004381_abnormal_hair_follicle | 1.57907332 |
| 50 | MP0003077_abnormal_cell_cycle | 1.55443488 |
| 51 | MP0003724_increased_susceptibility_to | 1.53097300 |
| 52 | MP0000465_gastrointestinal_hemorrhage | 1.52155678 |
| 53 | MP0003866_abnormal_defecation | 1.49594781 |
| 54 | MP0006054_spinal_hemorrhage | 1.49112246 |
| 55 | MP0004957_abnormal_blastocyst_morpholog | 1.44812761 |
| 56 | MP0003828_pulmonary_edema | 1.42851406 |
| 57 | MP0001533_abnormal_skeleton_physiology | 1.38349833 |
| 58 | MP0003111_abnormal_nucleus_morphology | 1.33416210 |
| 59 | MP0010094_abnormal_chromosome_stability | 1.32035401 |
| 60 | MP0003448_altered_tumor_morphology | 1.31810938 |
| 61 | MP0003183_abnormal_peptide_metabolism | 1.31375923 |
| 62 | MP0003075_altered_response_to | 1.30932341 |
| 63 | MP0002933_joint_inflammation | 1.29160016 |
| 64 | MP0005058_abnormal_lysosome_morphology | 1.28634520 |
| 65 | MP0003566_abnormal_cell_adhesion | 1.27444457 |
| 66 | MP0002019_abnormal_tumor_incidence | 1.22476642 |
| 67 | MP0000604_amyloidosis | 1.21254290 |
| 68 | MP0005076_abnormal_cell_differentiation | 1.20766825 |
| 69 | MP0005174_abnormal_tail_pigmentation | 1.18065954 |
| 70 | MP0005023_abnormal_wound_healing | 1.17136888 |
| 71 | MP0003705_abnormal_hypodermis_morpholog | 1.16277520 |
| 72 | MP0010234_abnormal_vibrissa_follicle | 1.14547339 |
| 73 | MP0010307_abnormal_tumor_latency | 1.14450913 |
| 74 | MP0008007_abnormal_cellular_replicative | 1.11598411 |
| 75 | MP0005166_decreased_susceptibility_to | 1.08911250 |
| 76 | MP0008469_abnormal_protein_level | 1.08834054 |
| 77 | MP0005310_abnormal_salivary_gland | 1.08314095 |
| 78 | MP0000015_abnormal_ear_pigmentation | 1.03120171 |
| 79 | MP0003172_abnormal_lysosome_physiology | 1.01662372 |
| 80 | MP0003690_abnormal_glial_cell | 1.00852667 |
| 81 | MP0004883_abnormal_blood_vessel | 1.00533816 |
| 82 | MP0003453_abnormal_keratinocyte_physiol | 0.98618479 |
| 83 | MP0000350_abnormal_cell_proliferation | 0.97256500 |
| 84 | MP0009840_abnormal_foam_cell | 0.95522650 |
| 85 | MP0003045_fibrosis | 0.93045079 |
| 86 | MP0003656_abnormal_erythrocyte_physiolo | 0.91530834 |
| 87 | MP0003329_amyloid_beta_deposits | 0.91018214 |
| 88 | MP0003191_abnormal_cellular_cholesterol | 0.89168358 |
| 89 | MP0000313_abnormal_cell_death | 0.88474159 |
| 90 | MP0005409_darkened_coat_color | 0.86655129 |
| 91 | MP0002138_abnormal_hepatobiliary_system | 0.86347593 |
| 92 | MP0000249_abnormal_blood_vessel | 0.84825792 |
| 93 | MP0000343_altered_response_to | 0.83816254 |
| 94 | MP0002132_abnormal_respiratory_system | 0.82977377 |
| 95 | MP0005164_abnormal_response_to | 0.81960878 |
| 96 | MP0000477_abnormal_intestine_morphology | 0.79477107 |
| 97 | MP0001730_embryonic_growth_arrest | 0.78502267 |
| 98 | MP0001986_abnormal_taste_sensitivity | 0.78312284 |
| 99 | MP0008004_abnormal_stomach_pH | 0.76967198 |
| 100 | * MP0001958_emphysema | 0.76836699 |
| 101 | MP0005075_abnormal_melanosome_morpholog | 0.76334512 |
| 102 | MP0008058_abnormal_DNA_repair | 0.76158220 |
| 103 | MP0003795_abnormal_bone_structure | 0.75260933 |
| 104 | MP0008874_decreased_physiological_sensi | 0.74010937 |
| 105 | MP0009764_decreased_sensitivity_to | 0.73716585 |
| 106 | MP0001216_abnormal_epidermal_layer | 0.73157746 |
| 107 | MP0009763_increased_sensitivity_to | 0.71713992 |
| 108 | MP0001348_abnormal_lacrimal_gland | 0.70473565 |
| 109 | MP0005390_skeleton_phenotype | 0.68401964 |
| 110 | MP0004130_abnormal_muscle_cell | 0.67602385 |
| 111 | MP0009931_abnormal_skin_appearance | 0.67484473 |
| 112 | MP0002095_abnormal_skin_pigmentation | 0.66969081 |
| 113 | MP0000371_diluted_coat_color | 0.66255936 |
| 114 | MP0001851_eye_inflammation | 0.66059685 |
| 115 | MP0003091_abnormal_cell_migration | 0.66042280 |
| 116 | MP0004185_abnormal_adipocyte_glucose | 0.64348210 |
| 117 | MP0001663_abnormal_digestive_system | 0.64301854 |
| 118 | MP0004858_abnormal_nervous_system | 0.64263296 |
| 119 | MP0005501_abnormal_skin_physiology | 0.63002521 |
| 120 | MP0000569_abnormal_digit_pigmentation | 0.62022172 |
| 121 | MP0002080_prenatal_lethality | 0.60642622 |
| 122 | MP0008057_abnormal_DNA_replication | 0.59302784 |
| 123 | MP0003279_aneurysm | 0.59009976 |
| 124 | MP0002998_abnormal_bone_remodeling | 0.58556290 |
| 125 | MP0002877_abnormal_melanocyte_morpholog | 0.58191407 |
| 126 | MP0005621_abnormal_cell_physiology | 0.57974893 |
| 127 | MP0001849_ear_inflammation | 0.55831524 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Elevated erythrocyte sedimentation rate (HP:0003565) | 4.83184515 |
| 2 | Eczematoid dermatitis (HP:0000976) | 4.65127364 |
| 3 | Chronic otitis media (HP:0000389) | 4.53090913 |
| 4 | Recurrent abscess formation (HP:0002722) | 4.29450446 |
| 5 | Recurrent bronchitis (HP:0002837) | 3.99613669 |
| 6 | IgM deficiency (HP:0002850) | 3.89385515 |
| 7 | Recurrent bacterial skin infections (HP:0005406) | 3.81755935 |
| 8 | Cellulitis (HP:0100658) | 3.76864205 |
| 9 | Recurrent viral infections (HP:0004429) | 3.73096563 |
| 10 | Recurrent fungal infections (HP:0002841) | 3.66578433 |
| 11 | Interstitial pulmonary disease (HP:0006530) | 3.53231455 |
| 12 | Myositis (HP:0100614) | 3.45843718 |
| 13 | Pustule (HP:0200039) | 3.40831876 |
| 14 | Nasal polyposis (HP:0100582) | 3.30918091 |
| 15 | Thrombocytosis (HP:0001894) | 3.29151344 |
| 16 | Abnormality of the nasal mucosa (HP:0000433) | 3.20934162 |
| 17 | Petechiae (HP:0000967) | 3.09210770 |
| 18 | Gastrointestinal infarctions (HP:0005244) | 3.07385727 |
| 19 | Agammaglobulinemia (HP:0004432) | 3.05344098 |
| 20 | Increased IgE level (HP:0003212) | 3.03799976 |
| 21 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 3.01745514 |
| 22 | Abnormality of T cells (HP:0002843) | 2.97774806 |
| 23 | Retrobulbar optic neuritis (HP:0100654) | 2.96427146 |
| 24 | Optic neuritis (HP:0100653) | 2.96427146 |
| 25 | Panhypogammaglobulinemia (HP:0003139) | 2.95312246 |
| 26 | Abnormality of T cell physiology (HP:0011840) | 2.92024421 |
| 27 | Mediastinal lymphadenopathy (HP:0100721) | 2.90983440 |
| 28 | Abnormality of liposaccharide metabolism (HP:0010968) | 2.90386103 |
| 29 | Abnormality of glycosphingolipid metabolism (HP:0004343) | 2.90386103 |
| 30 | Abnormality of glycolipid metabolism (HP:0010969) | 2.90386103 |
| 31 | Verrucae (HP:0200043) | 2.85847367 |
| 32 | Papilloma (HP:0012740) | 2.85847367 |
| 33 | Dysostosis multiplex (HP:0000943) | 2.84911260 |
| 34 | Gastrointestinal inflammation (HP:0004386) | 2.82758692 |
| 35 | Obstructive lung disease (HP:0006536) | 2.81759945 |
| 36 | Chronic obstructive pulmonary disease (HP:0006510) | 2.81759945 |
| 37 | Abnormality of cells of the lymphoid lineage (HP:0012140) | 2.81063565 |
| 38 | Meningitis (HP:0001287) | 2.80352174 |
| 39 | Lymphopenia (HP:0001888) | 2.79581253 |
| 40 | Autoimmune thrombocytopenia (HP:0001973) | 2.74917061 |
| 41 | Abnormality of macrophages (HP:0004311) | 2.72527486 |
| 42 | T lymphocytopenia (HP:0005403) | 2.71279298 |
| 43 | Inflammation of the large intestine (HP:0002037) | 2.69613316 |
| 44 | Vasculitis (HP:0002633) | 2.69193499 |
| 45 | Abnormality of T cell number (HP:0011839) | 2.67715744 |
| 46 | Encephalitis (HP:0002383) | 2.66259875 |
| 47 | Abnormality of B cell number (HP:0010975) | 2.63319959 |
| 48 | B lymphocytopenia (HP:0010976) | 2.63319959 |
| 49 | Chronic mucocutaneous candidiasis (HP:0002728) | 2.62864767 |
| 50 | Recurrent cutaneous fungal infections (HP:0011370) | 2.62864767 |
| 51 | Recurrent skin infections (HP:0001581) | 2.61826135 |
| 52 | Purpura (HP:0000979) | 2.58644266 |
| 53 | Hypergammaglobulinemia (HP:0010702) | 2.52300570 |
| 54 | Reticulocytopenia (HP:0001896) | 2.51267889 |
| 55 | Emphysema (HP:0002097) | 2.50149575 |
| 56 | Periodontitis (HP:0000704) | 2.48925053 |
| 57 | Gastrointestinal stroma tumor (HP:0100723) | 2.47439689 |
| 58 | Recurrent gram-negative bacterial infections (HP:0005420) | 2.46189539 |
| 59 | Spontaneous hematomas (HP:0007420) | 2.44308159 |
| 60 | Colitis (HP:0002583) | 2.43682690 |
| 61 | Gingival bleeding (HP:0000225) | 2.43658686 |
| 62 | Osteomyelitis (HP:0002754) | 2.33480912 |
| 63 | Eosinophilia (HP:0001880) | 2.32179990 |
| 64 | Hematochezia (HP:0002573) | 2.31727302 |
| 65 | IgG deficiency (HP:0004315) | 2.31422072 |
| 66 | Skin ulcer (HP:0200042) | 2.30558596 |
| 67 | Leukocytosis (HP:0001974) | 2.30326534 |
| 68 | Chronic sinusitis (HP:0011109) | 2.30039453 |
| 69 | Systemic lupus erythematosus (HP:0002725) | 2.29936592 |
| 70 | Combined immunodeficiency (HP:0005387) | 2.28456381 |
| 71 | Gingivitis (HP:0000230) | 2.28106689 |
| 72 | Granulocytopenia (HP:0001913) | 2.27014427 |
| 73 | Abnormality of mucopolysaccharide metabolism (HP:0011020) | 2.26743263 |
| 74 | Abnormality of polysaccharide metabolism (HP:0011012) | 2.26743263 |
| 75 | Abnormality of glycosaminoglycan metabolism (HP:0004371) | 2.26743263 |
| 76 | Parkinsonism with favorable response to dopaminergic medication (HP:0002548) | 2.23174900 |
| 77 | Urinary glycosaminoglycan excretion (HP:0003541) | 2.23120686 |
| 78 | Mucopolysacchariduria (HP:0008155) | 2.23120686 |
| 79 | Amyloidosis (HP:0011034) | 2.22574583 |
| 80 | IgA deficiency (HP:0002720) | 2.21424098 |
| 81 | Abnormal number of erythroid precursors (HP:0012131) | 2.21327978 |
| 82 | Abnormality of cells of the erythroid lineage (HP:0012130) | 2.20975944 |
| 83 | Primitive reflexes (palmomental, snout, glabellar) (HP:0002476) | 2.19676951 |
| 84 | Thyroiditis (HP:0100646) | 2.16655262 |
| 85 | Lymphoma (HP:0002665) | 2.14492941 |
| 86 | Keratoconjunctivitis sicca (HP:0001097) | 2.14444010 |
| 87 | Hemorrhage of the eye (HP:0011885) | 2.13458868 |
| 88 | Orchitis (HP:0100796) | 2.11841413 |
| 89 | Thin bony cortex (HP:0002753) | 2.10685056 |
| 90 | Urticaria (HP:0001025) | 2.10026079 |
| 91 | Loss of speech (HP:0002371) | 2.09023327 |
| 92 | Increased density of long bones (HP:0006392) | 2.07334557 |
| 93 | Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204) | 2.06749609 |
| 94 | Recurrent lower respiratory tract infections (HP:0002783) | 2.06006978 |
| 95 | Severe combined immunodeficiency (HP:0004430) | 2.05370077 |
| 96 | Abnormality of eosinophils (HP:0001879) | 2.04125757 |
| 97 | Sepsis (HP:0100806) | 2.02384758 |
| 98 | Bronchitis (HP:0012387) | 2.01602383 |
| 99 | Poor head control (HP:0002421) | 2.01210288 |
| 100 | Restrictive lung disease (HP:0002091) | 1.98541646 |
| 101 | Peritonitis (HP:0002586) | 1.97359572 |
| 102 | Increased cerebral lipofuscin (HP:0011813) | 1.95955262 |
| 103 | Hepatosplenomegaly (HP:0001433) | 1.95674718 |
| 104 | Increased serum ferritin (HP:0003281) | 1.95609952 |
| 105 | Chest pain (HP:0100749) | 1.95462754 |
| 106 | Malnutrition (HP:0004395) | 1.94691311 |
| 107 | Recurrent sinusitis (HP:0011108) | 1.93088201 |
| 108 | Viral hepatitis (HP:0006562) | 1.92811813 |
| 109 | Abnormality of the anterior horn cell (HP:0006802) | 1.92408163 |
| 110 | Degeneration of anterior horn cells (HP:0002398) | 1.92408163 |
| 111 | Recurrent pneumonia (HP:0006532) | 1.91207318 |
| 112 | Stomatitis (HP:0010280) | 1.90870410 |
| 113 | Keratoconjunctivitis (HP:0001096) | 1.90725785 |
| 114 | Prolonged bleeding time (HP:0003010) | 1.89782897 |
| 115 | Abnormality of the fingertips (HP:0001211) | 1.87757709 |
| 116 | Increased IgM level (HP:0003496) | 1.87381385 |
| 117 | Basal ganglia calcification (HP:0002135) | 1.86561684 |
| 118 | Hypertensive crisis (HP:0100735) | 1.86305471 |
| 119 | Broad face (HP:0000283) | 1.86193591 |
| 120 | Abnormal platelet volume (HP:0011876) | 1.85823597 |
| 121 | Abnormality of the peritoneum (HP:0002585) | 1.85816381 |
| 122 | Hyperacusis (HP:0010780) | 1.85593569 |
| 123 | Vacuolated lymphocytes (HP:0001922) | 1.82510382 |
| 124 | Pallor (HP:0000980) | 1.82202251 |
| 125 | Slow saccadic eye movements (HP:0000514) | 1.81658651 |
| 126 | Hypochromic anemia (HP:0001931) | 1.81531832 |
| 127 | Arterial thrombosis (HP:0004420) | 1.80418227 |
| 128 | Epistaxis (HP:0000421) | 1.79934990 |
| 129 | Erythema (HP:0010783) | 1.76957506 |
| 130 | Vertebral compression fractures (HP:0002953) | 1.76507928 |
| 131 | Increased neuronal autofluorescent lipopigment (HP:0002074) | 1.76169288 |
| 132 | Hemoptysis (HP:0002105) | 1.73543598 |
| 133 | Multiple enchondromatosis (HP:0005701) | 1.72071888 |
| 134 | Pulmonary infiltrates (HP:0002113) | 1.69860335 |
| 135 | Cerebral aneurysm (HP:0004944) | 1.68405902 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MAP4K1 | 4.97259489 |
| 2 | PRPF4B | 2.79362081 |
| 3 | MAP3K10 | 2.75241219 |
| 4 | ERN1 | 2.68795752 |
| 5 | TRIB3 | 2.49258814 |
| 6 | TESK2 | 2.44957973 |
| 7 | TYK2 | 2.38340629 |
| 8 | STK10 | 2.27265759 |
| 9 | * BLK | 2.22026741 |
| 10 | PKN2 | 2.20538063 |
| 11 | TBK1 | 2.16123514 |
| 12 | EEF2K | 2.15255318 |
| 13 | JAK3 | 2.09975163 |
| 14 | LRRK2 | 1.99041062 |
| 15 | GRK6 | 1.94744626 |
| 16 | * ZAP70 | 1.91525806 |
| 17 | BTK | 1.81736468 |
| 18 | KIT | 1.75499396 |
| 19 | RPS6KA4 | 1.74618847 |
| 20 | SMG1 | 1.67756835 |
| 21 | CSF1R | 1.66231596 |
| 22 | BUB1 | 1.61513307 |
| 23 | TNK2 | 1.61006167 |
| 24 | MAP3K3 | 1.60525525 |
| 25 | KDR | 1.59494569 |
| 26 | IRAK4 | 1.58626885 |
| 27 | NME2 | 1.57954064 |
| 28 | PIM2 | 1.57740677 |
| 29 | TXK | 1.56546162 |
| 30 | IKBKE | 1.54860357 |
| 31 | TESK1 | 1.47661312 |
| 32 | * SYK | 1.46584110 |
| 33 | FGFR4 | 1.40082338 |
| 34 | MAP3K14 | 1.37425796 |
| 35 | CDC42BPA | 1.33656858 |
| 36 | JAK1 | 1.33515838 |
| 37 | SIK1 | 1.30906155 |
| 38 | MAP3K11 | 1.29087538 |
| 39 | SCYL2 | 1.26705490 |
| 40 | TGFBR2 | 1.25310457 |
| 41 | NEK2 | 1.23690375 |
| 42 | IKBKB | 1.19213071 |
| 43 | TLK1 | 1.19113100 |
| 44 | CSK | 1.18920063 |
| 45 | MARK2 | 1.16895059 |
| 46 | PRKD2 | 1.16025780 |
| 47 | FGR | 1.15768669 |
| 48 | ITK | 1.15296196 |
| 49 | FLT3 | 1.13603046 |
| 50 | HCK | 1.13183174 |
| 51 | MAP3K1 | 1.11543929 |
| 52 | TEC | 1.11354825 |
| 53 | LCK | 1.08698544 |
| 54 | EIF2AK1 | 1.07352491 |
| 55 | PIM1 | 1.02774156 |
| 56 | PAK4 | 0.99825076 |
| 57 | RPS6KB2 | 0.99053851 |
| 58 | TAOK2 | 0.97878424 |
| 59 | MAPK12 | 0.97242945 |
| 60 | MAP2K3 | 0.95530756 |
| 61 | MATK | 0.94064528 |
| 62 | TGFBR1 | 0.92798920 |
| 63 | MAP3K8 | 0.91454723 |
| 64 | RIPK1 | 0.90740164 |
| 65 | MAPKAPK3 | 0.89180856 |
| 66 | CLK1 | 0.88250997 |
| 67 | PDPK1 | 0.88076894 |
| 68 | * LYN | 0.87161719 |
| 69 | KSR2 | 0.86315350 |
| 70 | FGFR3 | 0.82629834 |
| 71 | PTK6 | 0.81220809 |
| 72 | MARK3 | 0.80537430 |
| 73 | RIPK4 | 0.79731990 |
| 74 | SIK3 | 0.78203573 |
| 75 | PDK1 | 0.77290831 |
| 76 | CDK4 | 0.76074982 |
| 77 | MAPK11 | 0.74722113 |
| 78 | ALK | 0.73687497 |
| 79 | CHUK | 0.73664073 |
| 80 | MST4 | 0.73531281 |
| 81 | NEK9 | 0.72383819 |
| 82 | EPHB1 | 0.72291344 |
| 83 | HIPK2 | 0.72157762 |
| 84 | IRAK2 | 0.71551350 |
| 85 | LIMK1 | 0.70741314 |
| 86 | MAPK7 | 0.70302761 |
| 87 | MAP3K6 | 0.69490540 |
| 88 | ICK | 0.68952677 |
| 89 | FES | 0.68208772 |
| 90 | WEE1 | 0.67821903 |
| 91 | MAP3K7 | 0.67368343 |
| 92 | IRAK3 | 0.66058600 |
| 93 | TAOK1 | 0.64727244 |
| 94 | MAP3K13 | 0.64255431 |
| 95 | ILK | 0.64069306 |
| 96 | CDC7 | 0.63799921 |
| 97 | EPHA3 | 0.62357633 |
| 98 | MAPKAPK2 | 0.62265116 |
| 99 | CAMKK1 | 0.62148904 |
| 100 | TAOK3 | 0.61635242 |
| 101 | JAK2 | 0.60803537 |
| 102 | CDK12 | 0.60718984 |
| 103 | BMPR2 | 0.60058684 |
| 104 | RET | 0.58769452 |
| 105 | FYN | 0.58127264 |
| 106 | SIK2 | 0.55965151 |
| 107 | STK4 | 0.54709212 |
| 108 | STK38 | 0.53708122 |
| 109 | NLK | 0.52650827 |
| 110 | MAP2K2 | 0.52537280 |
| 111 | RPS6KA2 | 0.52023078 |
| 112 | PRKG2 | 0.50908329 |
| 113 | IRAK1 | 0.49685018 |
| 114 | DYRK3 | 0.45718460 |
| 115 | PASK | 0.45331865 |
| 116 | PRKD1 | 0.44979780 |
| 117 | ATR | 0.44887555 |
| 118 | ARAF | 0.44628291 |
| 119 | MAP2K6 | 0.43312946 |
| 120 | RPS6KA6 | 0.43116470 |
| 121 | PTK2B | 0.42181980 |
| 122 | CDK7 | 0.41759184 |
| 123 | CDK6 | 0.40785155 |
| 124 | TTN | 0.40371516 |
| 125 | PAK1 | 0.39952339 |
| 126 | PIK3CG | 0.38737202 |
| 127 | BMX | 0.38019914 |
| 128 | AURKB | 0.36166122 |
| 129 | CAMKK2 | 0.35237497 |
| 130 | PRKCQ | 0.35185480 |
| 131 | RPS6KL1 | 0.33890046 |
| 132 | RPS6KC1 | 0.33890046 |
| 133 | MAPK4 | 0.33429672 |
| 134 | PRKCD | 0.32906672 |
| 135 | TSSK6 | 0.31654458 |
| 136 | DYRK1B | 0.31474409 |
| 137 | CCNB1 | 0.31329489 |
| 138 | RPS6KA1 | 0.30439166 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Primary immunodeficiency_Homo sapiens_hsa05340 | 3.06278068 |
| 2 | DNA replication_Homo sapiens_hsa03030 | 2.47186267 |
| 3 | Leishmaniasis_Homo sapiens_hsa05140 | 2.34291701 |
| 4 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 2.20477311 |
| 5 | Antigen processing and presentation_Homo sapiens_hsa04612 | 2.14729710 |
| 6 | Ribosome_Homo sapiens_hsa03010 | 2.11967593 |
| 7 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 1.95177204 |
| 8 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.91487783 |
| 9 | Measles_Homo sapiens_hsa05162 | 1.90653816 |
| 10 | Base excision repair_Homo sapiens_hsa03410 | 1.82585561 |
| 11 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.81219702 |
| 12 | Osteoclast differentiation_Homo sapiens_hsa04380 | 1.75863949 |
| 13 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 1.74759699 |
| 14 | Mismatch repair_Homo sapiens_hsa03430 | 1.68414256 |
| 15 | Proteasome_Homo sapiens_hsa03050 | 1.67774962 |
| 16 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.67402670 |
| 17 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 1.66996510 |
| 18 | Shigellosis_Homo sapiens_hsa05131 | 1.66205266 |
| 19 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.60242587 |
| 20 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 1.55223073 |
| 21 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 1.52182775 |
| 22 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 1.51300254 |
| 23 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 1.51057547 |
| 24 | Legionellosis_Homo sapiens_hsa05134 | 1.49955413 |
| 25 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 1.48408943 |
| 26 | Apoptosis_Homo sapiens_hsa04210 | 1.44370722 |
| 27 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 1.43262903 |
| 28 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 1.43041731 |
| 29 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 1.41768766 |
| 30 | Spliceosome_Homo sapiens_hsa03040 | 1.39919547 |
| 31 | Influenza A_Homo sapiens_hsa05164 | 1.38086908 |
| 32 | Toxoplasmosis_Homo sapiens_hsa05145 | 1.37003238 |
| 33 | Viral myocarditis_Homo sapiens_hsa05416 | 1.35402163 |
| 34 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 1.31578614 |
| 35 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 1.30672463 |
| 36 | Pertussis_Homo sapiens_hsa05133 | 1.30394160 |
| 37 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.29777929 |
| 38 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 1.26255652 |
| 39 | Hepatitis B_Homo sapiens_hsa05161 | 1.25771584 |
| 40 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 1.24027998 |
| 41 | Allograft rejection_Homo sapiens_hsa05330 | 1.22583131 |
| 42 | Tuberculosis_Homo sapiens_hsa05152 | 1.19439381 |
| 43 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.18400327 |
| 44 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 1.18123935 |
| 45 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 1.15419182 |
| 46 | TNF signaling pathway_Homo sapiens_hsa04668 | 1.10944625 |
| 47 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 1.09149735 |
| 48 | Salmonella infection_Homo sapiens_hsa05132 | 1.08727298 |
| 49 | Viral carcinogenesis_Homo sapiens_hsa05203 | 1.06845851 |
| 50 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 1.05954025 |
| 51 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 1.05313835 |
| 52 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.04996884 |
| 53 | Cell cycle_Homo sapiens_hsa04110 | 1.04725811 |
| 54 | Pancreatic cancer_Homo sapiens_hsa05212 | 1.04184804 |
| 55 | HTLV-I infection_Homo sapiens_hsa05166 | 1.00929240 |
| 56 | Other glycan degradation_Homo sapiens_hsa00511 | 0.96392033 |
| 57 | Homologous recombination_Homo sapiens_hsa03440 | 0.95408278 |
| 58 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.94342148 |
| 59 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.93154005 |
| 60 | RNA transport_Homo sapiens_hsa03013 | 0.93100380 |
| 61 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.92869746 |
| 62 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.89736107 |
| 63 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.88583957 |
| 64 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 0.88265821 |
| 65 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.87373763 |
| 66 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.86288858 |
| 67 | Malaria_Homo sapiens_hsa05144 | 0.86078366 |
| 68 | Hepatitis C_Homo sapiens_hsa05160 | 0.85782990 |
| 69 | Platelet activation_Homo sapiens_hsa04611 | 0.84511454 |
| 70 | Nucleotide excision repair_Homo sapiens_hsa03420 | 0.81903820 |
| 71 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 0.80809604 |
| 72 | Colorectal cancer_Homo sapiens_hsa05210 | 0.80506150 |
| 73 | Asthma_Homo sapiens_hsa05310 | 0.80043599 |
| 74 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.79495444 |
| 75 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.78887273 |
| 76 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 0.78815044 |
| 77 | Lysosome_Homo sapiens_hsa04142 | 0.78159479 |
| 78 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.76614280 |
| 79 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.76102116 |
| 80 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.74747447 |
| 81 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.74068655 |
| 82 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.73181063 |
| 83 | Thyroid cancer_Homo sapiens_hsa05216 | 0.73165391 |
| 84 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.70739117 |
| 85 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.70428583 |
| 86 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.70234366 |
| 87 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.70127742 |
| 88 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.69814149 |
| 89 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.69751531 |
| 90 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.69593852 |
| 91 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.68765668 |
| 92 | Amoebiasis_Homo sapiens_hsa05146 | 0.67645578 |
| 93 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.67633322 |
| 94 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.65678316 |
| 95 | Bladder cancer_Homo sapiens_hsa05219 | 0.64015848 |
| 96 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.63831099 |
| 97 | Endocytosis_Homo sapiens_hsa04144 | 0.62492919 |
| 98 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.60293155 |
| 99 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.58788239 |
| 100 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.57653082 |
| 101 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.54628757 |
| 102 | Galactose metabolism_Homo sapiens_hsa00052 | 0.54582813 |
| 103 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.54437443 |
| 104 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.53540404 |
| 105 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.53179165 |
| 106 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.52577828 |
| 107 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.51907771 |
| 108 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.51322500 |
| 109 | RNA polymerase_Homo sapiens_hsa03020 | 0.50844482 |
| 110 | Endometrial cancer_Homo sapiens_hsa05213 | 0.50330087 |
| 111 | Insulin resistance_Homo sapiens_hsa04931 | 0.49222294 |
| 112 | Glioma_Homo sapiens_hsa05214 | 0.48089305 |
| 113 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.46225017 |
| 114 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.45918436 |
| 115 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.45886065 |
| 116 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.45432960 |
| 117 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.43558971 |
| 118 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.43557506 |
| 119 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.43178217 |
| 120 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.42929598 |
| 121 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.42526948 |
| 122 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.42343736 |
| 123 | Phagosome_Homo sapiens_hsa04145 | 0.42280886 |
| 124 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.40575066 |
| 125 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.39582785 |

