DBP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the PAR bZIP transcription factor family and binds to specific sequences in the promoters of several genes, such as albumin, CYP2A4, and CYP2A5. The encoded protein can bind DNA as a homo- or heterodimer and is involved in the regulation of some circadian rhythm genes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sulfation (GO:0051923)5.63475409
2L-phenylalanine catabolic process (GO:0006559)5.26753949
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.26753949
4behavioral response to nicotine (GO:0035095)5.22805267
5L-phenylalanine metabolic process (GO:0006558)5.02968104
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.02968104
7cellular response to ATP (GO:0071318)4.87539630
8regulation of skeletal muscle contraction (GO:0014819)4.69017607
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.63463300
10alpha-linolenic acid metabolic process (GO:0036109)4.46627296
11aromatic amino acid family catabolic process (GO:0009074)4.46160848
12detection of light stimulus involved in sensory perception (GO:0050962)4.35450927
13detection of light stimulus involved in visual perception (GO:0050908)4.35450927
14mitochondrial respiratory chain complex I assembly (GO:0032981)4.30476619
15NADH dehydrogenase complex assembly (GO:0010257)4.30476619
16mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.30476619
17kynurenine metabolic process (GO:0070189)4.03130539
18lysine metabolic process (GO:0006553)4.02276442
19lysine catabolic process (GO:0006554)4.02276442
20bile acid biosynthetic process (GO:0006699)3.94335831
21cellular ketone body metabolic process (GO:0046950)3.92980621
22glyoxylate metabolic process (GO:0046487)3.88411284
23membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.88283806
24sulfur amino acid catabolic process (GO:0000098)3.85122966
25indole-containing compound catabolic process (GO:0042436)3.78209539
26indolalkylamine catabolic process (GO:0046218)3.78209539
27tryptophan catabolic process (GO:0006569)3.78209539
28cellular response to exogenous dsRNA (GO:0071360)3.78045754
29positive regulation of defense response to virus by host (GO:0002230)3.73104299
30high-density lipoprotein particle remodeling (GO:0034375)3.72841002
31glutamate metabolic process (GO:0006536)3.70311110
32fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.68940476
33protein complex biogenesis (GO:0070271)3.64414181
34cysteine metabolic process (GO:0006534)3.63719912
35dicarboxylic acid biosynthetic process (GO:0043650)3.61538655
36purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.60843379
373-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.60843379
38short-chain fatty acid metabolic process (GO:0046459)3.60154434
392-oxoglutarate metabolic process (GO:0006103)3.59808275
40regulation of triglyceride catabolic process (GO:0010896)3.56206420
41amino-acid betaine metabolic process (GO:0006577)3.55248833
42urea metabolic process (GO:0019627)3.54485072
43urea cycle (GO:0000050)3.54485072
44tryptophan metabolic process (GO:0006568)3.51610080
45negative regulation of mast cell activation (GO:0033004)3.51336244
46positive regulation of digestive system process (GO:0060456)3.50126736
47aspartate family amino acid catabolic process (GO:0009068)3.49006521
48bile acid metabolic process (GO:0008206)3.42693751
49alpha-amino acid catabolic process (GO:1901606)3.41781661
50purinergic nucleotide receptor signaling pathway (GO:0035590)3.40493002
51ketone body metabolic process (GO:1902224)3.40418638
52mitotic cell cycle arrest (GO:0071850)3.40079581
53protein carboxylation (GO:0018214)3.39806018
54peptidyl-glutamic acid carboxylation (GO:0017187)3.39806018
55reverse cholesterol transport (GO:0043691)3.39627189
56regulation of cholesterol esterification (GO:0010872)3.38883446
57regulation of bile acid biosynthetic process (GO:0070857)3.36812472
58negative regulation of fibrinolysis (GO:0051918)3.34268473
59protein import into peroxisome matrix (GO:0016558)3.33962360
60serine family amino acid catabolic process (GO:0009071)3.33187314
61triglyceride homeostasis (GO:0070328)3.32255166
62acylglycerol homeostasis (GO:0055090)3.32255166
63DNA deamination (GO:0045006)3.31566802
64regulation of fibrinolysis (GO:0051917)3.31524739
65fatty acid beta-oxidation (GO:0006635)3.30200283
66regulation of cholesterol homeostasis (GO:2000188)3.29538913
67positive regulation of cAMP-mediated signaling (GO:0043950)3.28982808
68cellular amino acid catabolic process (GO:0009063)3.28430803
69nitrogen cycle metabolic process (GO:0071941)3.27371891
70cellular modified amino acid catabolic process (GO:0042219)3.26036131
71mitochondrial respiratory chain complex assembly (GO:0033108)3.25833311
72ethanol oxidation (GO:0006069)3.25720409
73regulation of synapse structural plasticity (GO:0051823)3.25696222
74fatty acid transmembrane transport (GO:1902001)3.24452089
75dicarboxylic acid catabolic process (GO:0043649)3.24404263
76protein-lipid complex remodeling (GO:0034368)3.22683056
77macromolecular complex remodeling (GO:0034367)3.22683056
78plasma lipoprotein particle remodeling (GO:0034369)3.22683056
79positive regulation of fatty acid beta-oxidation (GO:0032000)3.20951390
80drug catabolic process (GO:0042737)3.20669900
81fatty acid oxidation (GO:0019395)3.17884223
82tyrosine metabolic process (GO:0006570)3.17870542
83complement activation, alternative pathway (GO:0006957)3.17151670
84negative regulation of cholesterol transport (GO:0032375)3.15886300
85negative regulation of sterol transport (GO:0032372)3.15886300
86phospholipid efflux (GO:0033700)3.15566160
87aromatic amino acid family metabolic process (GO:0009072)3.14869682
88lipid oxidation (GO:0034440)3.14777056
89monocarboxylic acid catabolic process (GO:0072329)3.13271784
90regulation of protein activation cascade (GO:2000257)3.12770526
91fatty acid catabolic process (GO:0009062)3.11719106
92coenzyme catabolic process (GO:0009109)3.11148523
93acetyl-CoA metabolic process (GO:0006084)3.10264897
94carnitine shuttle (GO:0006853)3.08952709
95homocysteine metabolic process (GO:0050667)3.08742437
96DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.04788968
97flavonoid metabolic process (GO:0009812)3.03659864
98positive regulation of lipid catabolic process (GO:0050996)3.02813932
99negative regulation of lipase activity (GO:0060192)3.02745304
100plasma lipoprotein particle clearance (GO:0034381)3.02628158
101cerebellar Purkinje cell differentiation (GO:0021702)3.01228562
102negative regulation of systemic arterial blood pressure (GO:0003085)3.00733175
103carboxylic acid catabolic process (GO:0046395)2.99991501
104organic acid catabolic process (GO:0016054)2.99991501
105GDP-mannose metabolic process (GO:0019673)2.99881178
106cellular glucuronidation (GO:0052695)2.99618769
107phospholipid homeostasis (GO:0055091)2.98799586
108regulation of somitogenesis (GO:0014807)2.98201152
109carnitine metabolic process (GO:0009437)2.98155628
110positive regulation of fatty acid oxidation (GO:0046321)2.95209692
111regulation of complement activation (GO:0030449)2.93637710
112fucose catabolic process (GO:0019317)2.92238620
113L-fucose metabolic process (GO:0042354)2.92238620
114L-fucose catabolic process (GO:0042355)2.92238620
115cytidine metabolic process (GO:0046087)2.91105585
116cytidine catabolic process (GO:0006216)2.91105585
117cytidine deamination (GO:0009972)2.91105585
118cholesterol catabolic process (GO:0006707)2.88866615
119sterol catabolic process (GO:0016127)2.88866615
120transepithelial transport (GO:0070633)2.86609823
121adaptation of signaling pathway (GO:0023058)2.85492103
122fatty acid homeostasis (GO:0055089)2.84224523
123succinate metabolic process (GO:0006105)2.84159561
124neuromuscular synaptic transmission (GO:0007274)2.83258065
125benzene-containing compound metabolic process (GO:0042537)2.82356771
126cholesterol efflux (GO:0033344)2.80657659
127negative regulation of synaptic transmission, GABAergic (GO:0032229)2.79891354
128exogenous drug catabolic process (GO:0042738)2.79482708
129low-density lipoprotein particle remodeling (GO:0034374)2.77332186
130cornea development in camera-type eye (GO:0061303)2.77173213
131positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.76013085
132regulation of defense response to virus by host (GO:0050691)2.75861260
133regulation of phospholipid biosynthetic process (GO:0071071)2.74680733
134urinary tract smooth muscle contraction (GO:0014848)2.73212447
135indolalkylamine metabolic process (GO:0006586)2.73131195
136valine metabolic process (GO:0006573)2.72301315
137regulation of fatty acid beta-oxidation (GO:0031998)2.71238081
138bile acid and bile salt transport (GO:0015721)2.70401900
139water-soluble vitamin biosynthetic process (GO:0042364)2.70271770
140regulation of cholesterol metabolic process (GO:0090181)2.68724840
141drug metabolic process (GO:0017144)2.67296670
142positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.67152384
143gamma-aminobutyric acid transport (GO:0015812)2.66272280
144activated T cell proliferation (GO:0050798)2.66188770
145dentate gyrus development (GO:0021542)2.65409244
146positive regulation of triglyceride metabolic process (GO:0090208)2.64994010
147branched-chain amino acid catabolic process (GO:0009083)2.63992092
148positive regulation of protein homooligomerization (GO:0032464)2.63830027
149drug transmembrane transport (GO:0006855)2.62786977
150regulation of fatty acid oxidation (GO:0046320)2.62571049
151regulation of triglyceride metabolic process (GO:0090207)2.62000890
152protein polyglutamylation (GO:0018095)2.61825510
153parturition (GO:0007567)2.59474343
154regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.59142697
155negative regulation of multicellular organism growth (GO:0040015)2.59052795
156preassembly of GPI anchor in ER membrane (GO:0016254)2.58394943
157DNA damage response, signal transduction resulting in transcription (GO:0042772)2.57912854
158negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.54304476
159positive regulation of potassium ion transmembrane transport (GO:1901381)2.53784036
160neuronal action potential (GO:0019228)2.50271360
161cell proliferation in forebrain (GO:0021846)2.49204250
162lens fiber cell differentiation (GO:0070306)2.48130602
163peristalsis (GO:0030432)2.47576492
164negative regulation of cell aging (GO:0090344)2.46030288
165regulation of synapse maturation (GO:0090128)2.45455829
166positive regulation of triglyceride biosynthetic process (GO:0010867)2.42782249
167phosphatidylglycerol biosynthetic process (GO:0006655)2.41577960
168primary amino compound metabolic process (GO:1901160)2.40097727
169regulation of action potential (GO:0098900)2.39297806
170cellular anion homeostasis (GO:0030002)2.39052682
171regulation of cAMP-mediated signaling (GO:0043949)2.38464026
172pyrimidine ribonucleoside catabolic process (GO:0046133)2.37963761
173sensory perception of taste (GO:0050909)2.37946728
174cardiovascular system development (GO:0072358)2.37877134
175photoreceptor cell development (GO:0042461)2.37583115
176interferon-gamma secretion (GO:0072643)2.36624567
177neuronal action potential propagation (GO:0019227)2.36009508
178mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.33960596
179pseudouridine synthesis (GO:0001522)2.32954097
180response to ATP (GO:0033198)2.32839814
181positive regulation of synapse maturation (GO:0090129)2.32778270
182replicative senescence (GO:0090399)2.32482350
183purinergic receptor signaling pathway (GO:0035587)2.31829127
184serotonin metabolic process (GO:0042428)2.31784583
185iron coordination entity transport (GO:1901678)2.31692729
186negative regulation of Rho protein signal transduction (GO:0035024)2.31682411
187NAD biosynthetic process (GO:0009435)2.31051648
188mast cell activation involved in immune response (GO:0002279)2.29667445
189mast cell degranulation (GO:0043303)2.29667445
190response to misfolded protein (GO:0051788)2.28444929
191eye photoreceptor cell development (GO:0042462)2.28422089
192positive regulation of fatty acid transport (GO:2000193)2.26432336
193negative regulation of reactive oxygen species metabolic process (GO:2000378)2.25280060

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.65244734
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.95264661
3* RXR_22158963_ChIP-Seq_LIVER_Mouse4.90302728
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.17052649
5PPARA_22158963_ChIP-Seq_LIVER_Mouse4.13532631
6* LXR_22158963_ChIP-Seq_LIVER_Mouse3.95097594
7STAT6_21828071_ChIP-Seq_BEAS2B_Human3.62329935
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.50439891
9EGR1_23403033_ChIP-Seq_LIVER_Mouse3.00859822
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.85494372
11CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.63642564
12* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.29276604
13VDR_21846776_ChIP-Seq_THP-1_Human2.24583816
14CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.96141011
15P68_20966046_ChIP-Seq_HELA_Human1.96011163
16TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.83938848
17IRF8_22096565_ChIP-ChIP_GC-B_Human1.83499768
18ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.81112518
19MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.78448876
20BCL6_27268052_Chip-Seq_Bcells_Human1.78361366
21THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.77490551
22E2F1_20622854_ChIP-Seq_HELA_Human1.76571315
23EZH2_22144423_ChIP-Seq_EOC_Human1.75533303
24PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.71445134
25SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.71076706
26ERA_21632823_ChIP-Seq_H3396_Human1.65145914
27NOTCH1_21737748_ChIP-Seq_TLL_Human1.60862494
28HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.59601471
29ZNF274_21170338_ChIP-Seq_K562_Hela1.58509599
30BCOR_27268052_Chip-Seq_Bcells_Human1.57374459
31PHF8_20622854_ChIP-Seq_HELA_Human1.56997418
32DROSHA_22980978_ChIP-Seq_HELA_Human1.55873807
33SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.55529397
34MTF2_20144788_ChIP-Seq_MESCs_Mouse1.54552897
35* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.54165011
36CIITA_25753668_ChIP-Seq_RAJI_Human1.53081262
37* RARB_27405468_Chip-Seq_BRAIN_Mouse1.50966505
38* ELF1_20517297_ChIP-Seq_JURKAT_Human1.49703350
39YY1_22570637_ChIP-Seq_MALME-3M_Human1.45456732
40ERG_21242973_ChIP-ChIP_JURKAT_Human1.44287736
41TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.42415306
42SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.41406408
43MAF_26560356_Chip-Seq_TH2_Human1.41292140
44CTCF_20526341_ChIP-Seq_ESCs_Human1.40288285
45RNF2_18974828_ChIP-Seq_MESCs_Mouse1.40228712
46EZH2_18974828_ChIP-Seq_MESCs_Mouse1.40228712
47EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.39532835
48FOXA2_19822575_ChIP-Seq_HepG2_Human1.39107344
49TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.38654095
50EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.38514094
51RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.35716087
52SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.34835038
53JARID2_20075857_ChIP-Seq_MESCs_Mouse1.33827278
54SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.33608443
55MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.33404934
56ESR2_21235772_ChIP-Seq_MCF-7_Human1.30218868
57E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.29728571
58BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.28440152
59EZH2_27294783_Chip-Seq_ESCs_Mouse1.28273176
60BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.28259677
61* FOXP1_21924763_ChIP-Seq_HESCs_Human1.27998649
62SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.27588327
63CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.26967856
64SUZ12_27294783_Chip-Seq_ESCs_Mouse1.25258537
65SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.23894092
66E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.23714981
67CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.23495028
68TAF2_19829295_ChIP-Seq_ESCs_Human1.22824904
69TP53_22573176_ChIP-Seq_HFKS_Human1.22404339
70CTCF_21964334_ChIP-Seq_BJAB-B_Human1.21368008
71TDRD3_21172665_ChIP-Seq_MCF-7_Human1.18908150
72TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.18721507
73ESR1_20079471_ChIP-ChIP_T-47D_Human1.18408076
74JARID2_20064375_ChIP-Seq_MESCs_Mouse1.18277042
75P53_21459846_ChIP-Seq_SAOS-2_Human1.18183875
76NANOG_20526341_ChIP-Seq_ESCs_Human1.17945697
77OCT4_20526341_ChIP-Seq_ESCs_Human1.17009052
78* CLOCK_20551151_ChIP-Seq_293T_Human1.16992215
79DNAJC2_21179169_ChIP-ChIP_NT2_Human1.16772799
80VDR_22108803_ChIP-Seq_LS180_Human1.16652928
81CBX2_27304074_Chip-Seq_ESCs_Mouse1.15593828
82YY1_21170310_ChIP-Seq_MESCs_Mouse1.14862931
83SA1_27219007_Chip-Seq_Bcells_Human1.13892420
84GATA1_22025678_ChIP-Seq_K562_Human1.13150022
85ZNF263_19887448_ChIP-Seq_K562_Human1.12740618
86GBX2_23144817_ChIP-Seq_PC3_Human1.12569559
87EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.12073290
88REST_21632747_ChIP-Seq_MESCs_Mouse1.11934328
89RARB_24833708_ChIP-Seq_LIVER_Mouse1.11823223
90VDR_24763502_ChIP-Seq_THP-1_Human1.11770509
91TET1_21451524_ChIP-Seq_MESCs_Mouse1.11733223
92RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.11606616
93P300_27268052_Chip-Seq_Bcells_Human1.11082322
94RARG_19884340_ChIP-ChIP_MEFs_Mouse1.10982912
95CTCF_27219007_Chip-Seq_ERYTHROID_Human1.10804191
96HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.09633589
97REST_18959480_ChIP-ChIP_MESCs_Mouse1.09491105
98* UTX_26944678_Chip-Seq_JUKART_Human1.08963489
99VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.08742078
100OCT4_19829295_ChIP-Seq_ESCs_Human1.06292939
101VDR_23849224_ChIP-Seq_CD4+_Human1.06232936
102BMI1_23680149_ChIP-Seq_NPCS_Mouse1.05291249
103* GATA3_21878914_ChIP-Seq_MCF-7_Human1.05180100
104XRN2_22483619_ChIP-Seq_HELA_Human1.05174379
105ETS1_20019798_ChIP-Seq_JURKAT_Human1.04984179
106LXR_22292898_ChIP-Seq_THP-1_Human1.04582718
107EED_16625203_ChIP-ChIP_MESCs_Mouse1.04260009
108GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.03882561
109CTCF_21964334_Chip-Seq_Bcells_Human1.03473478
110ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.03339452
111CTCF_27219007_Chip-Seq_Bcells_Human1.03144491
112SA1_27219007_Chip-Seq_ERYTHROID_Human1.03059126
113JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.02954211
114MYC_19829295_ChIP-Seq_ESCs_Human1.02749045
115NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.02087387
116* MAF_26560356_Chip-Seq_TH1_Human1.00130965
117TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.99617931
118TBX20_22328084_ChIP-Seq_HEART_Mouse0.99349427
119TBX20_22080862_ChIP-Seq_HEART_Mouse0.99349427
120EP300_21415370_ChIP-Seq_HL-1_Mouse0.98521574
121RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97438530
122NCOR_22424771_ChIP-Seq_293T_Human0.96882089
123RARA_24833708_ChIP-Seq_LIVER_Mouse0.96720538
124EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.95934482
125RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.95342407
126RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.93387937
127EZH2_27304074_Chip-Seq_ESCs_Mouse0.93234064
128CDX2_19796622_ChIP-Seq_MESCs_Mouse0.93142389
129* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.92778661
130* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.91819666
131AR_21572438_ChIP-Seq_LNCaP_Human0.90862309
132RNF2_27304074_Chip-Seq_ESCs_Mouse0.89635903
133BCAT_22108803_ChIP-Seq_LS180_Human0.88171808
134HTT_18923047_ChIP-ChIP_STHdh_Human0.86646670
135ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.85869145
136NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.84989333
137PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.84814151
138* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.84802863
139* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.84539372
140* HNF4A_19822575_ChIP-Seq_HepG2_Human0.84326695
141NR3C1_23031785_ChIP-Seq_PC12_Mouse0.83355114
142KDM2B_26808549_Chip-Seq_K562_Human0.82807543
143NRF2_20460467_ChIP-Seq_MEFs_Mouse0.80480324
144NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.80480324
145ZNF217_24962896_ChIP-Seq_MCF-7_Human0.78079342
146AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.77746170
147GATA1_19941826_ChIP-Seq_K562_Human0.75084842
148SMAD4_21741376_ChIP-Seq_HESCs_Human0.74714608
149IKZF1_21737484_ChIP-ChIP_HCT116_Human0.74609988
150GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.73970115
151PIAS1_25552417_ChIP-Seq_VCAP_Human0.73777575
152* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.73759432
153GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73613714
154ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.73323083
155SOX2_21211035_ChIP-Seq_LN229_Gbm0.72794014
156SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72730721
157KLF4_19829295_ChIP-Seq_ESCs_Human0.71954466
158MYC_27129775_Chip-Seq_CORNEA_Mouse0.71858219
159SOX2_27498859_Chip-Seq_STOMACH_Mouse0.68873769
160RING1B_27294783_Chip-Seq_ESCs_Mouse0.68095130
161HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.67804198
162AR_19668381_ChIP-Seq_PC3_Human0.67688030
163PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.67671873
164RAD21_21589869_ChIP-Seq_MESCs_Mouse0.67527891
165AUTS2_25519132_ChIP-Seq_293T-REX_Human0.65774904
166CREB1_26743006_Chip-Seq_LNCaP_Human0.65220997
167SMAD4_21799915_ChIP-Seq_A2780_Human0.64680495
168SMC4_20622854_ChIP-Seq_HELA_Human0.64317114
169SMAD3_21741376_ChIP-Seq_HESCs_Human0.64261244
170RXR_22108803_ChIP-Seq_LS180_Human0.64189231
171GATA1_19941827_ChIP-Seq_MEL_Mouse0.60275020
172CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.60178702
173RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.59971926

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.84464584
2MP0005360_urolithiasis5.27038917
3MP0005085_abnormal_gallbladder_physiolo4.58000070
4MP0005365_abnormal_bile_salt4.44768976
5MP0008875_abnormal_xenobiotic_pharmacok4.09873105
6MP0001986_abnormal_taste_sensitivity3.98677938
7MP0005423_abnormal_somatic_nervous3.42722026
8MP0002837_dystrophic_cardiac_calcinosis3.33035205
9MP0005171_absent_coat_pigmentation3.23410530
10MP0005174_abnormal_tail_pigmentation3.14804180
11MP0001968_abnormal_touch/_nociception2.95659830
12MP0010329_abnormal_lipoprotein_level2.92013225
13MP0002822_catalepsy2.79939173
14MP0003252_abnormal_bile_duct2.65311438
15MP0009840_abnormal_foam_cell2.53271577
16MP0002638_abnormal_pupillary_reflex2.50411009
17MP0003806_abnormal_nucleotide_metabolis2.42822576
18MP0003136_yellow_coat_color2.37268377
19MP0005332_abnormal_amino_acid2.29486905
20MP0003195_calcinosis2.20003806
21MP0005083_abnormal_biliary_tract2.10473359
22MP0004885_abnormal_endolymph2.03020527
23MP0004130_abnormal_muscle_cell2.01954176
24MP0002735_abnormal_chemical_nociception1.99058326
25MP0002736_abnormal_nociception_after1.97904429
26MP0002118_abnormal_lipid_homeostasis1.91265254
27MP0003646_muscle_fatigue1.88606043
28MP0001666_abnormal_nutrient_absorption1.87778883
29MP0000751_myopathy1.83002030
30MP0004859_abnormal_synaptic_plasticity1.82708463
31MP0001485_abnormal_pinna_reflex1.82553516
32MP0003191_abnormal_cellular_cholesterol1.64752708
33MP0002160_abnormal_reproductive_system1.63163519
34MP0004036_abnormal_muscle_relaxation1.61326978
35MP0005253_abnormal_eye_physiology1.59530407
36MP0004019_abnormal_vitamin_homeostasis1.57518149
37MP0002909_abnormal_adrenal_gland1.57058164
38MP0004142_abnormal_muscle_tone1.55221450
39MP0005670_abnormal_white_adipose1.54054038
40MP0005671_abnormal_response_to1.51501298
41MP0001188_hyperpigmentation1.49737052
42MP0004215_abnormal_myocardial_fiber1.48035009
43MP0001970_abnormal_pain_threshold1.46462077
44MP0005584_abnormal_enzyme/coenzyme_acti1.45561696
45MP0000609_abnormal_liver_physiology1.44787402
46MP0004043_abnormal_pH_regulation1.42756072
47MP0003329_amyloid_beta_deposits1.41305062
48MP0004742_abnormal_vestibular_system1.36787096
49MP0005319_abnormal_enzyme/_coenzyme1.36231178
50MP0006292_abnormal_olfactory_placode1.33020624
51MP0001440_abnormal_grooming_behavior1.31787455
52MP0005535_abnormal_body_temperature1.28535263
53MP0006072_abnormal_retinal_apoptosis1.27351661
54MP0003868_abnormal_feces_composition1.26308043
55MP0003635_abnormal_synaptic_transmissio1.24902609
56MP0006036_abnormal_mitochondrial_physio1.24243844
57MP0005389_reproductive_system_phenotype1.23029495
58MP0005330_cardiomyopathy1.22982229
59MP0009780_abnormal_chondrocyte_physiolo1.22751928
60MP0003690_abnormal_glial_cell1.22093179
61MP0003787_abnormal_imprinting1.19697523
62MP0002733_abnormal_thermal_nociception1.19510471
63MP0008877_abnormal_DNA_methylation1.19084278
64MP0004084_abnormal_cardiac_muscle1.19082238
65MP0002090_abnormal_vision1.17477595
66MP0000015_abnormal_ear_pigmentation1.17167100
67MP0000749_muscle_degeneration1.16639898
68MP0004381_abnormal_hair_follicle1.16398810
69MP0005666_abnormal_adipose_tissue1.16238693
70MP0002067_abnormal_sensory_capabilities1.15514561
71MP0009745_abnormal_behavioral_response1.15438616
72MP0005167_abnormal_blood-brain_barrier1.14260921
73MP0002254_reproductive_system_inflammat1.13466988
74MP0002928_abnormal_bile_duct1.12941684
75MP0005410_abnormal_fertilization1.09338619
76MP0008961_abnormal_basal_metabolism1.08583302
77MP0002078_abnormal_glucose_homeostasis1.08249243
78MP0000604_amyloidosis1.08125119
79MP0009643_abnormal_urine_homeostasis1.07907929
80MP0004133_heterotaxia1.07116311
81MP0000013_abnormal_adipose_tissue1.06990825
82MP0002653_abnormal_ependyma_morphology1.06026632
83MP0002876_abnormal_thyroid_physiology1.05657379
84MP0000685_abnormal_immune_system1.03565603
85MP0005620_abnormal_muscle_contractility1.03372516
86MP0001919_abnormal_reproductive_system1.02559109
87MP0002971_abnormal_brown_adipose1.01744488
88MP0005377_hearing/vestibular/ear_phenot1.01708971
89MP0003878_abnormal_ear_physiology1.01708971
90MP0000538_abnormal_urinary_bladder1.01513920
91MP0002269_muscular_atrophy1.01070257
92MP0005386_behavior/neurological_phenoty0.99799601
93MP0004924_abnormal_behavior0.99799601
94MP0003011_delayed_dark_adaptation0.99524424
95MP0000750_abnormal_muscle_regeneration0.99371280
96MP0000569_abnormal_digit_pigmentation0.98901668
97MP0002138_abnormal_hepatobiliary_system0.97100953
98MP0003075_altered_response_to0.96639331
99* MP0002064_seizures0.96499492
100MP0004147_increased_porphyrin_level0.95593588
101MP0002063_abnormal_learning/memory/cond0.94888523
102MP0004145_abnormal_muscle_electrophysio0.94846040
103MP0000747_muscle_weakness0.94754878
104MP0008874_decreased_physiological_sensi0.94079151
105MP0000631_abnormal_neuroendocrine_gland0.93272759
106MP0003137_abnormal_impulse_conducting0.91976086
107MP0004087_abnormal_muscle_fiber0.91480682
108MP0001501_abnormal_sleep_pattern0.91051113
109MP0010368_abnormal_lymphatic_system0.90569395
110MP0001764_abnormal_homeostasis0.90389055
111MP0004270_analgesia0.89065955
112MP0005646_abnormal_pituitary_gland0.88668391
113MP0000230_abnormal_systemic_arterial0.88023804
114MP0002557_abnormal_social/conspecific_i0.87788798
115MP0003633_abnormal_nervous_system0.86744239
116MP0004085_abnormal_heartbeat0.86015877
117MP0001963_abnormal_hearing_physiology0.85993374
118MP0001800_abnormal_humoral_immune0.84992181
119MP0003705_abnormal_hypodermis_morpholog0.84227968
120MP0009046_muscle_twitch0.82744988
121MP0002163_abnormal_gland_morphology0.82208035
122MP0005375_adipose_tissue_phenotype0.82022820
123MP0002972_abnormal_cardiac_muscle0.81755778
124MP0000026_abnormal_inner_ear0.81681280
125MP0005334_abnormal_fat_pad0.79794312
126MP0002734_abnormal_mechanical_nocicepti0.78478430
127MP0008569_lethality_at_weaning0.77549683
128MP0001486_abnormal_startle_reflex0.76901678
129MP0002229_neurodegeneration0.76578804
130MP0004185_abnormal_adipocyte_glucose0.76330186
131MP0002095_abnormal_skin_pigmentation0.75707964
132MP0005645_abnormal_hypothalamus_physiol0.75165234
133* MP0002272_abnormal_nervous_system0.74897647
134MP0005551_abnormal_eye_electrophysiolog0.74417952
135MP0002572_abnormal_emotion/affect_behav0.74347707
136MP0002752_abnormal_somatic_nervous0.73645115
137MP0002933_joint_inflammation0.73542043
138MP0000372_irregular_coat_pigmentation0.73237402
139MP0002723_abnormal_immune_serum0.73171503
140MP0001544_abnormal_cardiovascular_syste0.72847510
141MP0005385_cardiovascular_system_phenoty0.72847510
142MP0005448_abnormal_energy_balance0.72432445
143MP0006276_abnormal_autonomic_nervous0.72218250
144MP0005636_abnormal_mineral_homeostasis0.71944760
145MP0005075_abnormal_melanosome_morpholog0.71915737
146MP0009764_decreased_sensitivity_to0.71835654
147MP0002332_abnormal_exercise_endurance0.71624018
148MP0001765_abnormal_ion_homeostasis0.71534863
149MP0008872_abnormal_physiological_respon0.71519507
150MP0006138_congestive_heart_failure0.71237960
151MP0001324_abnormal_eye_pigmentation0.70706947
152MP0005647_abnormal_sex_gland0.70223867
153MP0002882_abnormal_neuron_morphology0.69918227
154MP0001756_abnormal_urination0.69555404
155MP0005195_abnormal_posterior_eye0.69486113
156MP0009642_abnormal_blood_homeostasis0.69228055
157MP0008775_abnormal_heart_ventricle0.68758954
158MP0003638_abnormal_response/metabolism_0.67153813
159MP0003880_abnormal_central_pattern0.67136820
160MP0000470_abnormal_stomach_morphology0.65529836
161MP0003879_abnormal_hair_cell0.65083518
162MP0005266_abnormal_metabolism0.64809735
163* MP0001502_abnormal_circadian_rhythm0.63438689
164MP0004484_altered_response_of0.63436699
165MP0003656_abnormal_erythrocyte_physiolo0.61952367

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)5.32446706
2Deep venous thrombosis (HP:0002625)4.90850037
3Xanthomatosis (HP:0000991)4.66158625
4Intrahepatic cholestasis (HP:0001406)4.58021466
5Ketosis (HP:0001946)4.37141143
6Hyperlipoproteinemia (HP:0010980)4.28305755
7Congenital stationary night blindness (HP:0007642)4.26253441
8Abnormality of monocarboxylic acid metabolism (HP:0010996)4.07817719
9Attenuation of retinal blood vessels (HP:0007843)4.04049797
10Prolonged partial thromboplastin time (HP:0003645)4.03614418
11Ketoacidosis (HP:0001993)3.90139128
12Decreased circulating renin level (HP:0003351)3.81850468
13Hyperammonemia (HP:0001987)3.81786915
14Hypoglycemic coma (HP:0001325)3.78045175
15Hyperglycinuria (HP:0003108)3.73290556
16Hypobetalipoproteinemia (HP:0003563)3.72952616
17Rib fusion (HP:0000902)3.71661939
18Decreased electroretinogram (ERG) amplitude (HP:0000654)3.70991113
19Hypoalphalipoproteinemia (HP:0003233)3.52397064
20Abnormality of serine family amino acid metabolism (HP:0010894)3.51764518
21Abnormality of glycine metabolism (HP:0010895)3.51764518
22Hypoplasia of the pons (HP:0012110)3.45343661
23Complement deficiency (HP:0004431)3.45177326
24Hyperglycinemia (HP:0002154)3.38889591
25Hypolipoproteinemia (HP:0010981)3.35856674
26Exercise-induced myalgia (HP:0003738)3.34025554
27Type II lissencephaly (HP:0007260)3.18932177
28Myoglobinuria (HP:0002913)3.18274505
29Abolished electroretinogram (ERG) (HP:0000550)3.14006217
30Abnormality of the pons (HP:0007361)3.13221609
31Abnormality of fatty-acid metabolism (HP:0004359)3.13132654
32Anomalous pulmonary venous return (HP:0010772)3.13054549
33Pendular nystagmus (HP:0012043)3.11568369
34Decreased central vision (HP:0007663)3.10634323
35Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.04636259
36Gout (HP:0001997)3.01293738
37Abnormality of glutamine family amino acid metabolism (HP:0010902)3.00702693
38Epidermoid cyst (HP:0200040)2.99563493
39Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.96143091
40Delayed CNS myelination (HP:0002188)2.93735203
41Bony spicule pigmentary retinopathy (HP:0007737)2.89307163
42Pancreatic cysts (HP:0001737)2.81549836
43Polydipsia (HP:0001959)2.80276685
44Abnormal drinking behavior (HP:0030082)2.80276685
45Chorioretinal atrophy (HP:0000533)2.80236352
46Hypercholesterolemia (HP:0003124)2.78706706
47Congenital sensorineural hearing impairment (HP:0008527)2.77175876
48Genetic anticipation (HP:0003743)2.75845677
49Cerebellar dysplasia (HP:0007033)2.75332015
50Abnormality of the pulmonary veins (HP:0011718)2.72867352
51Sudden death (HP:0001699)2.70072128
52Abnormality of the common coagulation pathway (HP:0010990)2.68377591
53Abnormality of aspartate family amino acid metabolism (HP:0010899)2.66958119
54Abnormality of midbrain morphology (HP:0002418)2.62868291
55Molar tooth sign on MRI (HP:0002419)2.62868291
56Dicarboxylic aciduria (HP:0003215)2.62219544
57Abnormality of dicarboxylic acid metabolism (HP:0010995)2.62219544
58Hepatocellular necrosis (HP:0001404)2.60484988
59Abnormality of sulfur amino acid metabolism (HP:0004339)2.57480462
60Skin nodule (HP:0200036)2.56962918
61Hyperinsulinemic hypoglycemia (HP:0000825)2.56065280
62Joint hemorrhage (HP:0005261)2.54546860
63Late onset (HP:0003584)2.54095345
64Metabolic acidosis (HP:0001942)2.52799718
65Pancreatic fibrosis (HP:0100732)2.52532017
66Progressive cerebellar ataxia (HP:0002073)2.52495404
67Lipid accumulation in hepatocytes (HP:0006561)2.52059697
68Cholelithiasis (HP:0001081)2.51411430
69Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.50794551
70Nephronophthisis (HP:0000090)2.50324204
71Abnormality of methionine metabolism (HP:0010901)2.50307595
72Abnormality of the intrinsic pathway (HP:0010989)2.47798261
73Abnormal gallbladder morphology (HP:0012437)2.46586996
74Exercise-induced muscle cramps (HP:0003710)2.46166342
75Atrioventricular block (HP:0001678)2.45059914
76Hemiplegia (HP:0002301)2.43973043
77Mitochondrial inheritance (HP:0001427)2.43333600
78Abnormal rod and cone electroretinograms (HP:0008323)2.41843506
79Renal Fanconi syndrome (HP:0001994)2.41284393
80True hermaphroditism (HP:0010459)2.39987939
81Hypoglycemic seizures (HP:0002173)2.39865339
82Hyperbilirubinemia (HP:0002904)2.39397077
83Status epilepticus (HP:0002133)2.37778938
84Abnormality of purine metabolism (HP:0004352)2.37279578
85Fat malabsorption (HP:0002630)2.37125471
86Tubular atrophy (HP:0000092)2.36453485
87Abnormal number of erythroid precursors (HP:0012131)2.36109710
88Cerebral edema (HP:0002181)2.34845614
89Squamous cell carcinoma (HP:0002860)2.34265021
90Calf muscle hypertrophy (HP:0008981)2.34168451
91Facial diplegia (HP:0001349)2.33970101
92Abnormal gallbladder physiology (HP:0012438)2.30422138
93Cholecystitis (HP:0001082)2.30422138
94Aplasia/Hypoplasia of the patella (HP:0006498)2.28930572
95Hypoalbuminemia (HP:0003073)2.26261037
96Abnormal albumin level (HP:0012116)2.26261037
97Lethargy (HP:0001254)2.24897728
98Heart block (HP:0012722)2.23645195
99Right ventricular cardiomyopathy (HP:0011663)2.23476608
100Abnormality of DNA repair (HP:0003254)2.22928645
101Muscle hypertrophy of the lower extremities (HP:0008968)2.22647929
102Increased hepatocellular lipid droplets (HP:0006565)2.22539142
103Premature graying of hair (HP:0002216)2.22449588
104Abnormality of complement system (HP:0005339)2.21789904
105Febrile seizures (HP:0002373)2.21048552
106Patellar aplasia (HP:0006443)2.19549156
107Abnormality of serum amino acid levels (HP:0003112)2.19448389
108Asplenia (HP:0001746)2.19290849
109Focal motor seizures (HP:0011153)2.19096050
110Sensorimotor neuropathy (HP:0007141)2.16781880
111Mesangial abnormality (HP:0001966)2.15605888
112Increased muscle lipid content (HP:0009058)2.14753837
113Polyuria (HP:0000103)2.14151785
114Annular pancreas (HP:0001734)2.12748947
115Absent rod-and cone-mediated responses on ERG (HP:0007688)2.12528195
116Akinesia (HP:0002304)2.11975245
117Increased CSF lactate (HP:0002490)2.11788023
118Myotonia (HP:0002486)2.11608475
1193-Methylglutaconic aciduria (HP:0003535)2.11439023
120Neonatal onset (HP:0003623)2.10638140
121Palpitations (HP:0001962)2.10435606
122Asymmetric septal hypertrophy (HP:0001670)2.09588222
123Myokymia (HP:0002411)2.09495067
124Oral leukoplakia (HP:0002745)2.09449894
125Conjugated hyperbilirubinemia (HP:0002908)2.09193770
126Aplasia/Hypoplasia of the spleen (HP:0010451)2.09148475
127Clumsiness (HP:0002312)2.08588475
128Abnormality of renin-angiotensin system (HP:0000847)2.08457395
129Chronic hepatic failure (HP:0100626)2.08285783
130Bundle branch block (HP:0011710)2.08075331
131Generalized aminoaciduria (HP:0002909)2.07554554
132Hepatic necrosis (HP:0002605)2.07123772
133Amyloidosis (HP:0011034)2.06077558
134Abnormal atrioventricular conduction (HP:0005150)2.05791899
135Poikiloderma (HP:0001029)2.05469178
136Abnormality of the renal medulla (HP:0100957)2.04321712
137Absent thumb (HP:0009777)2.03889701
138Syncope (HP:0001279)2.03819334
139Rectovaginal fistula (HP:0000143)2.03599425
140Rectal fistula (HP:0100590)2.03599425
141Hyporeflexia of lower limbs (HP:0002600)2.01906127
142Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.01455807
143Increased intramyocellular lipid droplets (HP:0012240)2.01327819
144Vomiting (HP:0002013)2.00026414
145Abnormality of nucleobase metabolism (HP:0010932)1.99562145
146Severe muscular hypotonia (HP:0006829)1.99049580
147Vertebral fusion (HP:0002948)1.98380730
148Abnormality of the renal cortex (HP:0011035)1.98123301
149Epileptic encephalopathy (HP:0200134)1.98029538
150Neurofibrillary tangles (HP:0002185)1.96649779
151Abnormality of binocular vision (HP:0011514)1.94575785
152Diplopia (HP:0000651)1.94575785
153Impaired smooth pursuit (HP:0007772)1.93307126
154Confusion (HP:0001289)1.91555129
155Ventricular tachycardia (HP:0004756)1.90824777
156Irritability (HP:0000737)1.90532690
157Rhabdomyolysis (HP:0003201)1.90346042
158Hypokalemic alkalosis (HP:0001949)1.88786104
159Hyperuricemia (HP:0002149)1.87408256
160Increased purine levels (HP:0004368)1.87408256
161Abnormality of cells of the erythroid lineage (HP:0012130)1.86892228
162Hyperglycemia (HP:0003074)1.85309368
163Methylmalonic aciduria (HP:0012120)1.84183552
164Intestinal fistula (HP:0100819)1.83169128
165Abnormality of the Achilles tendon (HP:0005109)1.83087162
166Visual hallucinations (HP:0002367)1.83001783
167Gaze-evoked nystagmus (HP:0000640)1.82538018
168Severe visual impairment (HP:0001141)1.81987645
169Torticollis (HP:0000473)1.81632070
170Hyperventilation (HP:0002883)1.81531114
171Macular degeneration (HP:0000608)1.80616280
172Ventricular fibrillation (HP:0001663)1.80212813
173Prolonged QT interval (HP:0001657)1.80170228
174Hyperkalemia (HP:0002153)1.80089232
175Abnormality of the gallbladder (HP:0005264)1.79864377
176Hydroxyprolinuria (HP:0003080)1.78716307
177Abnormality of proline metabolism (HP:0010907)1.78716307
178Abnormal urine output (HP:0012590)1.78695648
179Anxiety (HP:0000739)1.78472973
180Mitral stenosis (HP:0001718)1.77971645
181Small hand (HP:0200055)1.77888820
182Atrial fibrillation (HP:0005110)1.77204264
183Cystic liver disease (HP:0006706)1.76824141
184Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.76646596
185Dysmetric saccades (HP:0000641)1.76337589
186Vascular calcification (HP:0004934)1.76151080
187Ventricular arrhythmia (HP:0004308)1.76132508
188Difficulty running (HP:0009046)1.75143132
189Testicular atrophy (HP:0000029)1.74659446
190IgG deficiency (HP:0004315)1.74080478
191Polycythemia (HP:0001901)1.74072088
192Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.73235749
193Brushfield spots (HP:0001088)1.73064861
194Abnormality of renal resorption (HP:0011038)1.71302004
195Absent speech (HP:0001344)1.70336384
196Medial flaring of the eyebrow (HP:0010747)1.67090486
197Methylmalonic acidemia (HP:0002912)1.66600874

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK14.59084784
2EPHA44.15549597
3BCKDK3.96379760
4FRK2.97800804
5ADRBK22.89812428
6ZAK2.85237955
7PINK12.41871723
8TRIB32.41013487
9SIK12.33324440
10INSRR2.24028016
11PHKG12.17830931
12PHKG22.17830931
13TTN2.15814952
14ACVR1B2.13604977
15LMTK22.09593158
16DAPK22.04088501
17MAP2K42.03498812
18ERN11.93865694
19BLK1.89094822
20GRK11.87559827
21TXK1.82088387
22GRK61.74608912
23NTRK31.70338297
24SIK21.69212657
25RIPK11.67207662
26MAP4K11.66520322
27STK161.64875698
28MAP3K91.57278740
29KSR21.52971017
30PKN21.50217992
31BMPR1B1.49330335
32OBSCN1.45297216
33IKBKB1.44068988
34WNK41.43070586
35MAP3K71.40822058
36MAP3K41.36670851
37NUAK11.36041128
38MYLK1.35941015
39PDK41.33688876
40PDK31.33688876
41FGFR41.33615343
42PRKD31.28611993
43TAF11.27087072
44MAP2K61.26331971
45ADRBK11.24524759
46CAMKK11.24341931
47MAP3K131.24252468
48PAK61.21648527
49NTRK11.20215344
50GRK71.18179449
51STK381.17964205
52MAPKAPK31.17178211
53CDK191.14252778
54TNK21.11443089
55MAPK121.10645613
56MAPK131.09546973
57MAP3K21.09156795
58VRK11.08880182
59MAP2K21.05319016
60MARK31.02727910
61OXSR11.01017131
62RPS6KA61.00771677
63PDPK10.99508680
64VRK20.98229961
65FGFR20.97608601
66TIE10.96938286
67PIM20.93617889
68PIM10.93416258
69PRKAA20.92625603
70SGK30.92427118
71MAPK150.89136313
72PIK3CG0.89071393
73NTRK20.88920764
74NEK10.88916613
75PRKCQ0.88664133
76PAK30.88570914
77MAPKAPK50.88277415
78MUSK0.87166988
79DMPK0.84397251
80CAMK10.83456526
81SGK4940.83213647
82SGK2230.83213647
83MAP3K110.81252785
84PRKCH0.81206638
85RPS6KA50.80874443
86CAMK1G0.79912550
87TAOK10.79045492
88MAP3K10.78964900
89AKT30.78547980
90SGK20.78481418
91MINK10.77586810
92PRKD10.77520312
93PDK20.77425993
94CDK50.76832253
95PDK10.76628737
96WNK10.76607054
97RPS6KC10.75620473
98RPS6KL10.75620473
99SYK0.75128225
100IKBKE0.74784807
101HIPK20.74316272
102CAMKK20.73928959
103CAMK2G0.73183474
104CAMK1D0.72938352
105RET0.72198200
106MAP4K20.71043997
107CASK0.70453221
108PTK60.68835786
109ARAF0.67875070
110MAP2K70.67424523
111MAPK110.67315171
112MST1R0.66980966
113TBK10.66925983
114PKN10.66802133
115PRKAA10.66390653
116MAP2K10.65371754
117STK390.65090417
118PTK2B0.64695057
119TAOK30.64629220
120PRKACG0.64465705
121CAMK40.64321323
122CAMK2D0.63713199
123PDGFRA0.63653076
124CAMK2A0.63448528
125JAK20.62706097
126PRKCI0.61454269
127PRKCZ0.59386239
128PRKCG0.59030335
129FLT30.56500141
130PIK3CA0.56009605
131MAP2K30.55764224
132RPS6KA20.54775330
133ABL20.53601505
134FER0.53126225
135MARK20.52794492
136RIPK40.51376434
137MAP3K30.50815933
138SGK10.50264238
139LYN0.49667057
140PRKD20.48983236
141TNIK0.47508362
142GRK50.45899892
143FES0.45710567
144PRKACA0.45516823
145TYRO30.45211245
146CDC42BPA0.44743800
147JAK10.44654409
148TGFBR20.44425606
149DAPK30.43561521
150RPS6KA30.42717233
151MAPK70.42694648
152DYRK30.42694391
153STK110.42639463
154AURKA0.42345475
155CSNK1G30.41427776
156CSNK1G20.41085184
157CSNK1A1L0.41024173

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.70539739
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.24155226
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.22683825
4Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.87592431
5Arginine biosynthesis_Homo sapiens_hsa002202.72494226
6Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.69275165
7Fatty acid degradation_Homo sapiens_hsa000712.60667417
8Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.53365730
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.35356824
10Butanoate metabolism_Homo sapiens_hsa006502.31536275
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.26191461
12Propanoate metabolism_Homo sapiens_hsa006402.24766633
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.20755496
14Systemic lupus erythematosus_Homo sapiens_hsa053222.19556884
15Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.17262418
16Tryptophan metabolism_Homo sapiens_hsa003802.16216082
17Oxidative phosphorylation_Homo sapiens_hsa001902.15729500
18Intestinal immune network for IgA production_Homo sapiens_hsa046722.09442896
192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.08250485
20Fatty acid metabolism_Homo sapiens_hsa012121.98974191
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.98608990
22Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.93752145
23PPAR signaling pathway_Homo sapiens_hsa033201.88947238
24Phototransduction_Homo sapiens_hsa047441.88426268
25alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.72056928
26Linoleic acid metabolism_Homo sapiens_hsa005911.71546075
27Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.69479634
28Alcoholism_Homo sapiens_hsa050341.67993491
29Bile secretion_Homo sapiens_hsa049761.65218182
30Complement and coagulation cascades_Homo sapiens_hsa046101.64636590
31Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.64545218
32Pentose and glucuronate interconversions_Homo sapiens_hsa000401.64388112
33Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.63858239
34Peroxisome_Homo sapiens_hsa041461.62539346
35Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.59770029
36beta-Alanine metabolism_Homo sapiens_hsa004101.59258333
37Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.59246201
38Taste transduction_Homo sapiens_hsa047421.57969820
39Primary immunodeficiency_Homo sapiens_hsa053401.57524421
40Parkinsons disease_Homo sapiens_hsa050121.55528491
41Pyruvate metabolism_Homo sapiens_hsa006201.46301300
42Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.44129182
43Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.41980628
44Chemical carcinogenesis_Homo sapiens_hsa052041.38246793
45Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.37214403
46Histidine metabolism_Homo sapiens_hsa003401.34073273
47Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.33073553
48Phenylalanine metabolism_Homo sapiens_hsa003601.31832565
49Starch and sucrose metabolism_Homo sapiens_hsa005001.31380219
50Sulfur metabolism_Homo sapiens_hsa009201.27172386
51Carbon metabolism_Homo sapiens_hsa012001.26860697
52Alzheimers disease_Homo sapiens_hsa050101.26064542
53Caffeine metabolism_Homo sapiens_hsa002321.22131696
54Steroid hormone biosynthesis_Homo sapiens_hsa001401.15910790
55Glycosaminoglycan degradation_Homo sapiens_hsa005311.10333959
56Tyrosine metabolism_Homo sapiens_hsa003501.09928160
57Biosynthesis of amino acids_Homo sapiens_hsa012301.08572593
58Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.07388520
59Retinol metabolism_Homo sapiens_hsa008301.05103672
60Fatty acid elongation_Homo sapiens_hsa000621.04870895
61Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.04782322
62ABC transporters_Homo sapiens_hsa020101.04093745
63Ether lipid metabolism_Homo sapiens_hsa005651.03492119
64Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.03427337
65Huntingtons disease_Homo sapiens_hsa050160.96951007
66RNA polymerase_Homo sapiens_hsa030200.94436843
67Fatty acid biosynthesis_Homo sapiens_hsa000610.93755653
68Ovarian steroidogenesis_Homo sapiens_hsa049130.93256025
69Fat digestion and absorption_Homo sapiens_hsa049750.93064553
70Collecting duct acid secretion_Homo sapiens_hsa049660.87942962
71Maturity onset diabetes of the young_Homo sapiens_hsa049500.87729392
72Drug metabolism - other enzymes_Homo sapiens_hsa009830.87612168
73Regulation of autophagy_Homo sapiens_hsa041400.87037897
74Arginine and proline metabolism_Homo sapiens_hsa003300.85547681
75Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.84932379
76Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.84917216
77Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.84634648
78Staphylococcus aureus infection_Homo sapiens_hsa051500.83088919
79Glycerolipid metabolism_Homo sapiens_hsa005610.82433802
80Cholinergic synapse_Homo sapiens_hsa047250.80313606
81GABAergic synapse_Homo sapiens_hsa047270.79443189
82Cysteine and methionine metabolism_Homo sapiens_hsa002700.76729682
83Mineral absorption_Homo sapiens_hsa049780.74175854
84Selenocompound metabolism_Homo sapiens_hsa004500.73727966
85Arachidonic acid metabolism_Homo sapiens_hsa005900.73719655
86Ribosome_Homo sapiens_hsa030100.71749659
87Graft-versus-host disease_Homo sapiens_hsa053320.71315507
88MAPK signaling pathway_Homo sapiens_hsa040100.70777089
89Fanconi anemia pathway_Homo sapiens_hsa034600.69192991
90Asthma_Homo sapiens_hsa053100.68844342
91Serotonergic synapse_Homo sapiens_hsa047260.67000226
92Cardiac muscle contraction_Homo sapiens_hsa042600.66902749
93Insulin secretion_Homo sapiens_hsa049110.66054520
94RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.65365411
95Glucagon signaling pathway_Homo sapiens_hsa049220.63374742
96Adipocytokine signaling pathway_Homo sapiens_hsa049200.61953273
97Autoimmune thyroid disease_Homo sapiens_hsa053200.61456850
98Sulfur relay system_Homo sapiens_hsa041220.59774797
99cAMP signaling pathway_Homo sapiens_hsa040240.59404968
100Dorso-ventral axis formation_Homo sapiens_hsa043200.58332814
101Cyanoamino acid metabolism_Homo sapiens_hsa004600.57477989
102Circadian entrainment_Homo sapiens_hsa047130.57058912
103Dopaminergic synapse_Homo sapiens_hsa047280.56822168
104Lysine degradation_Homo sapiens_hsa003100.56434806
105Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55517981
106Lysosome_Homo sapiens_hsa041420.54919025
107Hedgehog signaling pathway_Homo sapiens_hsa043400.54691997
108Insulin resistance_Homo sapiens_hsa049310.54552290
109Aldosterone synthesis and secretion_Homo sapiens_hsa049250.54103597
110Salivary secretion_Homo sapiens_hsa049700.53619432
111Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.53343604
112Type I diabetes mellitus_Homo sapiens_hsa049400.53256310
113Homologous recombination_Homo sapiens_hsa034400.52838942
114Olfactory transduction_Homo sapiens_hsa047400.51491339
115Sphingolipid metabolism_Homo sapiens_hsa006000.51406895
116Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.50655222
117Renin secretion_Homo sapiens_hsa049240.50338903
118Allograft rejection_Homo sapiens_hsa053300.48400090
119Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.48314017
120Folate biosynthesis_Homo sapiens_hsa007900.47577735
121Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.47335074
122Circadian rhythm_Homo sapiens_hsa047100.47097864
123Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.46288230
124Amphetamine addiction_Homo sapiens_hsa050310.46237181
125Dilated cardiomyopathy_Homo sapiens_hsa054140.46146092
126Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.45978063
127Nicotine addiction_Homo sapiens_hsa050330.45738097
128Glutamatergic synapse_Homo sapiens_hsa047240.45652428
129Gastric acid secretion_Homo sapiens_hsa049710.45625444
130Morphine addiction_Homo sapiens_hsa050320.43807227
131Cocaine addiction_Homo sapiens_hsa050300.43111441
132Synaptic vesicle cycle_Homo sapiens_hsa047210.42150952
133Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.40410749
134NOD-like receptor signaling pathway_Homo sapiens_hsa046210.40251161
135Fructose and mannose metabolism_Homo sapiens_hsa000510.39854195
136Type II diabetes mellitus_Homo sapiens_hsa049300.38435715
137NF-kappa B signaling pathway_Homo sapiens_hsa040640.38278563
138T cell receptor signaling pathway_Homo sapiens_hsa046600.37859789
139Vitamin digestion and absorption_Homo sapiens_hsa049770.37502688
140Calcium signaling pathway_Homo sapiens_hsa040200.37431496
141Basal transcription factors_Homo sapiens_hsa030220.36838583
142Galactose metabolism_Homo sapiens_hsa000520.36506446
143Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.36052844
144Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.35663784
145Prion diseases_Homo sapiens_hsa050200.35515678
146Vitamin B6 metabolism_Homo sapiens_hsa007500.35011817
147Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.33641089
148Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.33582490
149Long-term potentiation_Homo sapiens_hsa047200.31895501
150Glycerophospholipid metabolism_Homo sapiens_hsa005640.31163488
151Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.31064038
152Oxytocin signaling pathway_Homo sapiens_hsa049210.30882107
153AMPK signaling pathway_Homo sapiens_hsa041520.30615009
154Insulin signaling pathway_Homo sapiens_hsa049100.30158184
155Carbohydrate digestion and absorption_Homo sapiens_hsa049730.29251878
156Metabolic pathways_Homo sapiens_hsa011000.29183227
157Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.27937898

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