DBX1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lens fiber cell development (GO:0070307)9.10666693
2chondrocyte proliferation (GO:0035988)8.85160565
3endocardial cushion morphogenesis (GO:0003203)7.93985599
4regulation of chemokine-mediated signaling pathway (GO:0070099)7.83666476
5epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)7.78086581
6paraxial mesoderm development (GO:0048339)7.68237465
7heart valve formation (GO:0003188)7.67982632
8negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)7.36217166
9pyrimidine nucleobase catabolic process (GO:0006208)7.12997977
10neuron projection extension involved in neuron projection guidance (GO:1902284)7.11036866
11axon extension involved in axon guidance (GO:0048846)7.11036866
12positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)6.96394710
13cell migration involved in heart development (GO:0060973)6.82405552
14negative regulation of astrocyte differentiation (GO:0048712)6.78692487
15mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)6.76936126
16venous blood vessel morphogenesis (GO:0048845)6.58804086
17negative regulation of oligodendrocyte differentiation (GO:0048715)6.52090587
18Notch signaling involved in heart development (GO:0061314)6.45573531
19regulation of neuroblast proliferation (GO:1902692)6.33044359
20regulation of somitogenesis (GO:0014807)6.29818029
21neuronal stem cell maintenance (GO:0097150)6.21885277
22somite development (GO:0061053)6.20596769
23ventricular trabecula myocardium morphogenesis (GO:0003222)6.13182113
24epithelial cell differentiation involved in prostate gland development (GO:0060742)6.07280728
25collecting duct development (GO:0072044)6.01795637
26midgut development (GO:0007494)6.00682675
27exocrine pancreas development (GO:0031017)5.92432443
28cellular response to follicle-stimulating hormone stimulus (GO:0071372)5.89632811
29positive regulation of neural precursor cell proliferation (GO:2000179)5.85620428
30coronary vasculature morphogenesis (GO:0060977)5.75677123
31regulation of astrocyte differentiation (GO:0048710)5.74438213
32regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)5.74344606
33mesenchyme morphogenesis (GO:0072132)5.74318877
34myoblast migration (GO:0051451)5.71663253
35negative regulation of glial cell differentiation (GO:0045686)5.71045875
36outer ear morphogenesis (GO:0042473)5.64961541
37atrioventricular valve morphogenesis (GO:0003181)5.63896259
38negative regulation of calcium ion-dependent exocytosis (GO:0045955)5.61818738
39lens morphogenesis in camera-type eye (GO:0002089)5.61321397
40inner ear receptor cell differentiation (GO:0060113)5.58348768
41nucleobase catabolic process (GO:0046113)5.45161187
42positive regulation of astrocyte differentiation (GO:0048711)5.43072148
43limb bud formation (GO:0060174)5.42751245
44embryonic camera-type eye development (GO:0031076)5.36344804
45barbed-end actin filament capping (GO:0051016)5.21551976
46thalamus development (GO:0021794)5.21358041
47regulation of extracellular matrix organization (GO:1903053)5.16544835
48regulation of endothelial cell chemotaxis (GO:2001026)5.06619149
49negative regulation of glial cell proliferation (GO:0060253)4.99301867
50cardiac left ventricle morphogenesis (GO:0003214)4.97139556
51heart trabecula morphogenesis (GO:0061384)4.85829146
52renal system development (GO:0072001)4.83738881
53positive regulation of keratinocyte differentiation (GO:0045618)4.69740090
54pyrimidine dimer repair (GO:0006290)4.68320913
55dorsal/ventral neural tube patterning (GO:0021904)4.65042024
56negative regulation of cytosolic calcium ion concentration (GO:0051481)4.55936997
57positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003604.53450528
58regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)4.52079239
59response to muramyl dipeptide (GO:0032495)4.49933455
60type B pancreatic cell development (GO:0003323)4.46305323
61left/right axis specification (GO:0070986)4.44476434
62positive regulation of synapse maturation (GO:0090129)4.41265072
63negative regulation of myotube differentiation (GO:0010832)4.38128217
64regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901214.34944074
65behavioral response to nicotine (GO:0035095)4.33023451
66embryonic viscerocranium morphogenesis (GO:0048703)4.31130391
67muscle cell fate commitment (GO:0042693)4.27567446
68digestive tract morphogenesis (GO:0048546)4.23221051
69negative regulation of epidermis development (GO:0045683)4.23181638
70cell wall macromolecule catabolic process (GO:0016998)4.22162344
71positive regulation of protein homooligomerization (GO:0032464)4.21005228
72apoptotic process involved in morphogenesis (GO:0060561)4.19991922
73cochlea development (GO:0090102)4.19890868
74cullin deneddylation (GO:0010388)4.19591861
75negative chemotaxis (GO:0050919)4.17153934
76endoderm development (GO:0007492)4.14092846
77mechanoreceptor differentiation (GO:0042490)4.13097988
78negative regulation of gliogenesis (GO:0014014)4.12863488
79negative regulation of myoblast differentiation (GO:0045662)4.11914809
80nephron tubule development (GO:0072080)4.08065525
81response to follicle-stimulating hormone (GO:0032354)4.06080800
82cardiac ventricle formation (GO:0003211)4.02353235
83negative regulation of smoothened signaling pathway (GO:0045879)4.01107175
84trabecula morphogenesis (GO:0061383)3.96879635
85protein deneddylation (GO:0000338)3.93016248
86amyloid precursor protein catabolic process (GO:0042987)3.92024620
87negative regulation of chondrocyte differentiation (GO:0032331)3.89110998
88cellular response to cholesterol (GO:0071397)3.86631674
89chaperone-mediated protein transport (GO:0072321)3.83414696
90endothelial tube morphogenesis (GO:0061154)3.79105181
91morphogenesis of an endothelium (GO:0003159)3.79105181
92forebrain morphogenesis (GO:0048853)3.78188191
93cardiac muscle cell proliferation (GO:0060038)3.77351767
94atrial septum morphogenesis (GO:0060413)3.76540919
95cell migration involved in sprouting angiogenesis (GO:0002042)3.74203018
96establishment of nucleus localization (GO:0040023)3.73541424
97regulation of synapse maturation (GO:0090128)3.71989590
98Notch receptor processing (GO:0007220)3.71741437
99chaperone mediated protein folding requiring cofactor (GO:0051085)3.70199535
100regulation of neural precursor cell proliferation (GO:2000177)3.69250462
101astrocyte differentiation (GO:0048708)3.68365852
102positive regulation of extracellular matrix organization (GO:1903055)3.66647070
103cardiac chamber formation (GO:0003207)3.63598950
104positive regulation of neuroblast proliferation (GO:0002052)3.62813492
105renal tubule development (GO:0061326)3.59156106
106positive regulation of BMP signaling pathway (GO:0030513)3.55084284
107hair follicle morphogenesis (GO:0031069)3.50980589
108cell wall macromolecule metabolic process (GO:0044036)3.50452504
109positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)3.48974087
110base-excision repair, AP site formation (GO:0006285)3.47525021
111calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.47503927
112regulation of hair follicle development (GO:0051797)3.45795981
113cardiac epithelial to mesenchymal transition (GO:0060317)3.44427201
114regulation of oligodendrocyte differentiation (GO:0048713)3.40548267
115mesenchymal to epithelial transition (GO:0060231)3.37620259
116muscle cell migration (GO:0014812)3.35864982
117mammary gland epithelial cell differentiation (GO:0060644)3.35809896
118ventricular septum morphogenesis (GO:0060412)3.34764360
119cell surface receptor signaling pathway involved in heart development (GO:0061311)3.30270585
120respiratory tube development (GO:0030323)3.29462690
121spinal cord development (GO:0021510)3.27537984
122adult heart development (GO:0007512)3.25493698
123retinal ganglion cell axon guidance (GO:0031290)3.25274839
124regulation of mammary gland epithelial cell proliferation (GO:0033599)3.20941116
125central nervous system neuron differentiation (GO:0021953)3.20865474
126peroxisome fission (GO:0016559)3.17136387
127neuron recognition (GO:0008038)3.08572392
128ribosomal small subunit assembly (GO:0000028)3.06756206
129coenzyme A metabolic process (GO:0015936)2.94020585
130inner mitochondrial membrane organization (GO:0007007)2.91133671
131positive regulation of Rho protein signal transduction (GO:0035025)2.87544810
132nonmotile primary cilium assembly (GO:0035058)2.87095809
133negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.84666843
134synaptic transmission, cholinergic (GO:0007271)2.83648051
135histone H4 deacetylation (GO:0070933)2.81749487
136negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.79922599
137negative regulation of translation, ncRNA-mediated (GO:0040033)2.79922599
138regulation of translation, ncRNA-mediated (GO:0045974)2.79922599
139regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.79216549
140appendage development (GO:0048736)2.78794191
141limb development (GO:0060173)2.78794191
142neuromuscular synaptic transmission (GO:0007274)2.77675762
143mitochondrial respiratory chain complex I assembly (GO:0032981)2.76250876
144NADH dehydrogenase complex assembly (GO:0010257)2.76250876
145mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.76250876
146viral transcription (GO:0019083)2.72327978
147positive regulation of stem cell proliferation (GO:2000648)2.71795273
148lysine catabolic process (GO:0006554)2.68694512
149lysine metabolic process (GO:0006553)2.68694512
150translational termination (GO:0006415)2.67747016
151DNA strand renaturation (GO:0000733)2.67379190
152suckling behavior (GO:0001967)2.65377423
153negative regulation of RNA splicing (GO:0033119)2.63265777
154negative regulation of chemotaxis (GO:0050922)2.63189860
155regulation of glucocorticoid secretion (GO:2000849)2.62949429
156regulation of helicase activity (GO:0051095)2.62536893
157nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.61030195
158establishment of mitochondrion localization (GO:0051654)2.60955009
159mitochondrion transport along microtubule (GO:0047497)2.59595562
160establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.59595562
161organelle disassembly (GO:1903008)2.58166676
162negative regulation of mRNA processing (GO:0050686)2.57985162
163DNA damage response, detection of DNA damage (GO:0042769)2.57426033
164cellular response to leptin stimulus (GO:0044320)2.57005697
165presynaptic membrane assembly (GO:0097105)2.50100018
166nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.50078244
167presynaptic membrane organization (GO:0097090)2.49429945
168lateral sprouting from an epithelium (GO:0060601)2.48560452
169cranial nerve development (GO:0021545)2.47747835
170snRNA transcription (GO:0009301)2.47393505
171positive regulation of transcription regulatory region DNA binding (GO:2000679)2.47027084
172mismatch repair (GO:0006298)2.46552873
173hippocampus development (GO:0021766)2.46443840
174positive regulation of mRNA processing (GO:0050685)2.45458853
175de novo posttranslational protein folding (GO:0051084)2.45170478
176protein complex localization (GO:0031503)2.43578398
177neural tube formation (GO:0001841)2.41748623
178specification of organ identity (GO:0010092)2.41334055
179prostate gland growth (GO:0060736)2.40703071
180coenzyme A biosynthetic process (GO:0015937)2.40451742
181protein-chromophore linkage (GO:0018298)2.37960207
182intraciliary transport (GO:0042073)2.37301583
183protein complex biogenesis (GO:0070271)2.37295036
184positive regulation of RNA splicing (GO:0033120)2.36890764
185neuron fate commitment (GO:0048663)2.35707609
186synapse assembly (GO:0007416)2.35581975
187morphogenesis of an epithelial sheet (GO:0002011)2.35184963
188inositol phosphate catabolic process (GO:0071545)2.34801775
189histone H3 deacetylation (GO:0070932)2.33797644
190forebrain neuron differentiation (GO:0021879)12.9133642
191epithelial cell fate commitment (GO:0072148)11.1308819
192lung epithelium development (GO:0060428)11.0405203
193axon ensheathment in central nervous system (GO:0032291)10.2471216
194central nervous system myelination (GO:0022010)10.2471216

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human9.56589945
2ZFP322A_24550733_ChIP-Seq_MESCs_Mouse6.21889608
3FOXM1_23109430_ChIP-Seq_U2OS_Human5.90752687
4RBPJ_22232070_ChIP-Seq_NCS_Mouse5.11893807
5SRY_22984422_ChIP-ChIP_TESTIS_Rat4.99927998
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.78891568
7* RNF2_18974828_ChIP-Seq_MESCs_Mouse3.53267630
8* EZH2_18974828_ChIP-Seq_MESCs_Mouse3.53267630
9MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.35131547
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.31570964
11TP63_19390658_ChIP-ChIP_HaCaT_Human3.14059373
12* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.90320015
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.83452341
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.79203879
15DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.68629746
16* CBX2_27304074_Chip-Seq_ESCs_Mouse2.66580979
17* EED_16625203_ChIP-ChIP_MESCs_Mouse2.64345040
18EST1_17652178_ChIP-ChIP_JURKAT_Human2.61466227
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.54977718
20* PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.52505869
21JARID2_20064375_ChIP-Seq_MESCs_Mouse2.45602823
22POU5F1_16153702_ChIP-ChIP_HESCs_Human2.38064036
23* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.37479215
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.36834178
25* RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.34695165
26* EZH2_27304074_Chip-Seq_ESCs_Mouse2.31012311
27* RNF2_27304074_Chip-Seq_NSC_Mouse2.21782430
28* TP53_20018659_ChIP-ChIP_R1E_Mouse2.18262027
29RNF2_27304074_Chip-Seq_ESCs_Mouse2.17075875
30PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.14923212
31* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.13962081
32EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.11426700
33GABP_17652178_ChIP-ChIP_JURKAT_Human2.10985403
34HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.09296586
35* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.02916825
36WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.00464542
37* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.99779364
38* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.96497803
39* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.91662734
40CDX2_20551321_ChIP-Seq_CACO-2_Human1.87945743
41GATA1_26923725_Chip-Seq_HPCs_Mouse1.86220332
42DROSHA_22980978_ChIP-Seq_HELA_Human1.85416459
43* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.82044781
44NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.80918194
45ZNF274_21170338_ChIP-Seq_K562_Hela1.80764202
46SOX2_18555785_ChIP-Seq_MESCs_Mouse1.79731123
47* EZH2_27294783_Chip-Seq_ESCs_Mouse1.76994189
48GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.76289065
49TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.74759989
50MYC_18555785_ChIP-Seq_MESCs_Mouse1.74465176
51* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.73904295
52AR_21909140_ChIP-Seq_LNCAP_Human1.73008182
53ETS1_20019798_ChIP-Seq_JURKAT_Human1.71235931
54THAP11_20581084_ChIP-Seq_MESCs_Mouse1.70818744
55WT1_19549856_ChIP-ChIP_CCG9911_Human1.61893546
56EGR1_19374776_ChIP-ChIP_THP-1_Human1.61538340
57SOX9_26525672_Chip-Seq_HEART_Mouse1.54730845
58EGR1_19032775_ChIP-ChIP_M12_Human1.52691224
59PCGF2_27294783_Chip-Seq_NPCs_Mouse1.52483018
60FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.49743949
61HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.49240537
62NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.45349618
63TTF2_22483619_ChIP-Seq_HELA_Human1.42544982
64* ISL1_27105846_Chip-Seq_CPCs_Mouse1.41816387
65YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.40231222
66FUS_26573619_Chip-Seq_HEK293_Human1.39188937
67ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.35402178
68RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.35248313
69CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.34167320
70FOXO3_23340844_ChIP-Seq_DLD1_Human1.33489978
71VDR_21846776_ChIP-Seq_THP-1_Human1.30479093
72OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.29498886
73ELK1_19687146_ChIP-ChIP_HELA_Human1.29334492
74SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.27282976
75TAF15_26573619_Chip-Seq_HEK293_Human1.26402362
76VDR_22108803_ChIP-Seq_LS180_Human1.24260269
77DNAJC2_21179169_ChIP-ChIP_NT2_Human1.24067898
78XRN2_22483619_ChIP-Seq_HELA_Human1.23849491
79* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.23808638
80* RING1B_27294783_Chip-Seq_ESCs_Mouse1.23258354
81* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.22886635
82JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.22622381
83FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.22195525
84POU3F2_20337985_ChIP-ChIP_501MEL_Human1.20038466
85CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.19506715
86ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.19036362
87REST_18959480_ChIP-ChIP_MESCs_Mouse1.18126712
88REST_21632747_ChIP-Seq_MESCs_Mouse1.16277513
89SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.15412873
90SOX2_16153702_ChIP-ChIP_HESCs_Human1.15257462
91STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.14947530
92RUNX1_26923725_Chip-Seq_HPCs_Mouse1.14483792
93FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.13876308
94LXR_22292898_ChIP-Seq_THP-1_Human1.12678175
95LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11017240
96ZFP281_27345836_Chip-Seq_ESCs_Mouse1.10605382
97SALL1_21062744_ChIP-ChIP_HESCs_Human1.10596449
98GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10047734
99DCP1A_22483619_ChIP-Seq_HELA_Human1.09489759
100PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.09330872
101KDM5A_27292631_Chip-Seq_BREAST_Human1.08923419
102NELFA_20434984_ChIP-Seq_ESCs_Mouse1.06881854
103ELK3_25401928_ChIP-Seq_HUVEC_Human1.05226076
104NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.04172153
105E2F1_18555785_ChIP-Seq_MESCs_Mouse1.04053600
106VDR_23849224_ChIP-Seq_CD4+_Human1.03756282
107* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.03743886
108CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.03311114
109POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.03243081
110EWS_26573619_Chip-Seq_HEK293_Human1.01535905
111CIITA_25753668_ChIP-Seq_RAJI_Human0.99322844
112GABP_19822575_ChIP-Seq_HepG2_Human0.99021322
113E2F4_17652178_ChIP-ChIP_JURKAT_Human0.98619770
114PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97397169
115MYC_18940864_ChIP-ChIP_HL60_Human0.97300627
116FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.96841995
117ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.96543756
118TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.95274544
119CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.95221066
120RING1B_27294783_Chip-Seq_NPCs_Mouse0.95135096
121ESR1_15608294_ChIP-ChIP_MCF-7_Human0.94702878
122ERG_21242973_ChIP-ChIP_JURKAT_Human0.93853175
123NFE2_27457419_Chip-Seq_LIVER_Mouse0.93625428
124IRF1_19129219_ChIP-ChIP_H3396_Human0.93064460
125DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.92563441
126STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.92309692
127* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.91370238
128SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.91226123
129KDM2B_26808549_Chip-Seq_K562_Human0.91100307
130TRIM28_21343339_ChIP-Seq_HEK293_Human0.91011842
131P300_19829295_ChIP-Seq_ESCs_Human0.90869092
132SUZ12_27294783_Chip-Seq_NPCs_Mouse0.90642626
133EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.90324679
134ELF1_20517297_ChIP-Seq_JURKAT_Human0.90218118
135CTCF_27219007_Chip-Seq_Bcells_Human0.90161881
136PCGF2_27294783_Chip-Seq_ESCs_Mouse0.88140678
137SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.87962251
138EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.87406533
139MYC_19079543_ChIP-ChIP_MESCs_Mouse0.87347763
140POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.86448955
141FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.86125588
142OCT4_18692474_ChIP-Seq_MEFs_Mouse0.85840721
143GATA1_19941826_ChIP-Seq_K562_Human0.85728280
144ER_23166858_ChIP-Seq_MCF-7_Human0.85305128
145HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.85032584
146MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.83916330
147CTBP1_25329375_ChIP-Seq_LNCAP_Human0.80544276
148TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.80185110
149ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.80183630
150EZH2_22144423_ChIP-Seq_EOC_Human0.80002572
151IGF1R_20145208_ChIP-Seq_DFB_Human0.79590104
152NANOG_16153702_ChIP-ChIP_HESCs_Human0.76856449
153TCF3_18692474_ChIP-Seq_MEFs_Mouse0.75678539
154SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.75579183
155POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.75442649
156FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.75175084
157EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.73508807
158ESR2_21235772_ChIP-Seq_MCF-7_Human0.72855537
159SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.72739654
160* BMI1_23680149_ChIP-Seq_NPCS_Mouse0.71983678
161POU5F1_16518401_ChIP-PET_MESCs_Mouse0.71872056
162JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.71715120
163SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.71702071
164CTBP2_25329375_ChIP-Seq_LNCAP_Human0.71194237
165CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.70589942
166POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.70404853
167CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.68542177
168GBX2_23144817_ChIP-Seq_PC3_Human0.66101712
169WT1_25993318_ChIP-Seq_PODOCYTE_Human0.65649364
170TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.65447193
171TP53_18474530_ChIP-ChIP_U2OS_Human0.65322289

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009780_abnormal_chondrocyte_physiolo8.92004347
2MP0010030_abnormal_orbit_morphology7.16888661
3MP0002653_abnormal_ependyma_morphology4.75639340
4MP0002102_abnormal_ear_morphology3.94426397
5MP0005257_abnormal_intraocular_pressure3.88366755
6MP0005171_absent_coat_pigmentation3.27833374
7MP0004381_abnormal_hair_follicle3.11619818
8MP0002249_abnormal_larynx_morphology3.11302099
9MP0002089_abnormal_postnatal_growth/wei3.08499475
10MP0001958_emphysema2.99773011
11MP0003183_abnormal_peptide_metabolism2.64499295
12MP0000631_abnormal_neuroendocrine_gland2.63144551
13MP0004134_abnormal_chest_morphology2.53822068
14MP0000049_abnormal_middle_ear2.24668066
15MP0000566_synostosis11.8434211
16MP0005645_abnormal_hypothalamus_physiol11.0703288
17MP0002938_white_spotting1.94853432
18MP0008789_abnormal_olfactory_epithelium1.94045838
19MP0001299_abnormal_eye_distance/1.93825387
20MP0003283_abnormal_digestive_organ1.80174754
21MP0005499_abnormal_olfactory_system1.70136251
22MP0005394_taste/olfaction_phenotype1.70136251
23MP0003941_abnormal_skin_development1.68241020
24MP0001984_abnormal_olfaction1.65856681
25MP0004142_abnormal_muscle_tone1.64785910
26MP0003938_abnormal_ear_development1.63385761
27MP0001188_hyperpigmentation1.58967654
28* MP0005423_abnormal_somatic_nervous1.58894593
29MP0000428_abnormal_craniofacial_morphol1.58571766
30MP0000762_abnormal_tongue_morphology1.55340755
31MP0003011_delayed_dark_adaptation1.53684726
32* MP0006276_abnormal_autonomic_nervous1.42540631
33MP0000647_abnormal_sebaceous_gland1.38881659
34MP0003121_genomic_imprinting1.33905473
35MP0010386_abnormal_urinary_bladder1.32994648
36MP0003787_abnormal_imprinting1.29238824
37MP0001293_anophthalmia1.28223107
38MP0004215_abnormal_myocardial_fiber1.27327189
39MP0008932_abnormal_embryonic_tissue1.27103967
40MP0008057_abnormal_DNA_replication1.26993193
41MP0004811_abnormal_neuron_physiology1.25851600
42MP0002234_abnormal_pharynx_morphology1.25545432
43MP0003115_abnormal_respiratory_system1.25167291
44MP0008877_abnormal_DNA_methylation1.23767129
45MP0003315_abnormal_perineum_morphology1.17130974
46MP0002822_catalepsy1.16945893
47MP0001486_abnormal_startle_reflex1.16890843
48MP0000778_abnormal_nervous_system1.15070204
49MP0000569_abnormal_digit_pigmentation1.14313573
50MP0003755_abnormal_palate_morphology1.14190398
51MP0002160_abnormal_reproductive_system1.13647988
52MP0002009_preneoplasia1.13114609
53* MP0002152_abnormal_brain_morphology1.11118663
54MP0002092_abnormal_eye_morphology1.06189041
55MP0005220_abnormal_exocrine_pancreas1.05517574
56MP0002734_abnormal_mechanical_nocicepti1.02859676
57MP0002697_abnormal_eye_size1.00647273
58MP0008058_abnormal_DNA_repair0.98595433
59MP0000163_abnormal_cartilage_morphology0.97882998
60MP0006072_abnormal_retinal_apoptosis0.97210429
61MP0002557_abnormal_social/conspecific_i0.94287630
62MP0000467_abnormal_esophagus_morphology0.93893171
63MP0009379_abnormal_foot_pigmentation0.93194958
64MP0000026_abnormal_inner_ear0.92373669
65MP0000733_abnormal_muscle_development0.92169542
66MP0002282_abnormal_trachea_morphology0.91524915
67MP0003122_maternal_imprinting0.87735021
68MP0000462_abnormal_digestive_system0.87575111
69MP0001346_abnormal_lacrimal_gland0.87014739
70MP0005670_abnormal_white_adipose0.86782817
71MP0003937_abnormal_limbs/digits/tail_de0.86520382
72MP0004197_abnormal_fetal_growth/weight/0.84041357
73MP0008569_lethality_at_weaning0.83194382
74MP0000579_abnormal_nail_morphology0.83157206
75MP0005508_abnormal_skeleton_morphology0.82734556
76MP0005248_abnormal_Harderian_gland0.81665383
77MP0002233_abnormal_nose_morphology0.80354928
78MP0009703_decreased_birth_body0.79474766
79MP0004233_abnormal_muscle_weight0.78295075
80MP0009672_abnormal_birth_weight0.77737205
81MP0005253_abnormal_eye_physiology0.77563857
82MP0000685_abnormal_immune_system0.77554419
83MP0010094_abnormal_chromosome_stability0.77266632
84MP0006035_abnormal_mitochondrial_morpho0.76230148
85MP0009250_abnormal_appendicular_skeleto0.76137348
86MP0002095_abnormal_skin_pigmentation0.75811009
87* MP0001943_abnormal_respiration0.73106312
88MP0000751_myopathy0.69452608
89MP0002909_abnormal_adrenal_gland0.69163214
90MP0004085_abnormal_heartbeat0.69154853
91MP0004145_abnormal_muscle_electrophysio0.68925915
92MP0009046_muscle_twitch0.68638010
93MP0003942_abnormal_urinary_system0.68201609
94MP0002069_abnormal_eating/drinking_beha0.68178074
95MP0000371_diluted_coat_color0.68176019
96MP0009053_abnormal_anal_canal0.68071089
97MP0004885_abnormal_endolymph0.68036695
98MP0004133_heterotaxia0.67141315
99* MP0002081_perinatal_lethality0.66915787
100MP0001286_abnormal_eye_development0.66699186
101MP0003943_abnormal_hepatobiliary_system0.66547198
102MP0001873_stomach_inflammation0.66501852
103MP0010770_preweaning_lethality0.65819644
104MP0002082_postnatal_lethality0.65819644
105MP0002064_seizures0.65551682
106MP0002928_abnormal_bile_duct0.65507129
107MP0003453_abnormal_keratinocyte_physiol0.65172619
108MP0000358_abnormal_cell_content/0.64715538
109MP0006054_spinal_hemorrhage0.64209685
110MP0003567_abnormal_fetal_cardiomyocyte0.63539428
111MP0004883_abnormal_blood_vessel0.63187700
112MP0002085_abnormal_embryonic_tissue0.62386630
113MP0010769_abnormal_survival0.60525056
114MP0002063_abnormal_learning/memory/cond0.59484537
115MP0005197_abnormal_uvea_morphology0.57726423
116MP0002184_abnormal_innervation0.57200130
117MP0003385_abnormal_body_wall0.56763480
118MP0000377_abnormal_hair_follicle0.56057005
119MP0008961_abnormal_basal_metabolism0.55970970
120MP0003111_abnormal_nucleus_morphology0.54885630
121MP0000003_abnormal_adipose_tissue0.53567969
122MP0004924_abnormal_behavior0.51390948
123MP0005386_behavior/neurological_phenoty0.51390948
124MP0003634_abnormal_glial_cell0.45748016
125MP0005623_abnormal_meninges_morphology0.43030181
126MP0003861_abnormal_nervous_system0.42986956
127MP0005646_abnormal_pituitary_gland0.42481068
128MP0002111_abnormal_tail_morphology0.42144892
129MP0002084_abnormal_developmental_patter0.42004842
130MP0005391_vision/eye_phenotype0.41844531
131MP0001533_abnormal_skeleton_physiology0.41480534
132MP0002113_abnormal_skeleton_development0.41270345
133MP0003935_abnormal_craniofacial_develop0.41154091
134MP0002115_abnormal_skeleton_extremities0.40689019
135MP0002116_abnormal_craniofacial_bone0.40053790
136* MP0000955_abnormal_spinal_cord0.36335640
137MP0002752_abnormal_somatic_nervous0.35803296
138MP0004859_abnormal_synaptic_plasticity0.34059413
139MP0005390_skeleton_phenotype0.33015589
140MP0003718_maternal_effect0.32562972
141MP0003137_abnormal_impulse_conducting0.32260694
142MP0001186_pigmentation_phenotype0.31901363
143* MP0002751_abnormal_autonomic_nervous0.31743746
144MP0005365_abnormal_bile_salt0.31582472
145MP0001784_abnormal_fluid_regulation0.31230536
146MP0002638_abnormal_pupillary_reflex0.31210247
147* MP0002882_abnormal_neuron_morphology0.30954800
148MP0000470_abnormal_stomach_morphology0.29920812
149MP0002932_abnormal_joint_morphology0.29695952
150MP0000383_abnormal_hair_follicle0.29577988
151MP0002109_abnormal_limb_morphology0.28744014
152MP0000350_abnormal_cell_proliferation0.27382001
153MP0001270_distended_abdomen0.27321267
154MP0003091_abnormal_cell_migration0.27001157
155* MP0003880_abnormal_central_pattern0.26405981
156MP0008872_abnormal_physiological_respon0.26287121
157MP0001697_abnormal_embryo_size0.25449349
158MP0003119_abnormal_digestive_system0.25437952
159MP0001529_abnormal_vocalization0.25336693
160MP0001664_abnormal_digestion0.25292716
161MP0002075_abnormal_coat/hair_pigmentati0.24211849
162MP0005381_digestive/alimentary_phenotyp0.24178455
163MP0002114_abnormal_axial_skeleton0.23445000

Predicted human phenotypes

RankGene SetZ-score
1Neonatal short-limb short stature (HP:0008921)8.53398790
2Partial duplication of thumb phalanx (HP:0009944)7.05241689
3Aplasia of the phalanges of the hand (HP:0009802)6.82577425
4Aplasia involving bones of the extremities (HP:0009825)6.82577425
5Aplasia involving bones of the upper limbs (HP:0009823)6.82577425
6Alacrima (HP:0000522)6.36131948
7Partial duplication of the phalanx of hand (HP:0009999)6.24815118
8Coronal craniosynostosis (HP:0004440)5.76176483
9Thickened helices (HP:0000391)5.26580894
10Anomalous pulmonary venous return (HP:0010772)5.21373750
11Decreased lacrimation (HP:0000633)5.13231385
12Recurrent corneal erosions (HP:0000495)5.03248025
13Xerostomia (HP:0000217)4.97584590
14Megalencephaly (HP:0001355)4.96534159
15Duplication of thumb phalanx (HP:0009942)4.83691569
16Abnormality of the lumbar spine (HP:0100712)4.83237130
17Abnormality of the middle phalanges of the toes (HP:0010183)4.79225693
18Abnormality of the costochondral junction (HP:0000919)4.62529967
19Infantile muscular hypotonia (HP:0008947)4.55503573
20Intestinal atresia (HP:0011100)4.54181049
21Abnormality of incisor morphology (HP:0011063)4.51290166
22Abnormality of the pulmonary veins (HP:0011718)4.50351649
23Nasolacrimal duct obstruction (HP:0000579)4.38503692
24Conical tooth (HP:0000698)4.19069266
25Abnormality of the salivary glands (HP:0010286)4.12317025
26Aplasia cutis congenita (HP:0001057)3.87874167
27Gonadal dysgenesis (HP:0000133)3.85073722
28Congenital primary aphakia (HP:0007707)3.80767903
29Natal tooth (HP:0000695)3.80026328
30Supernumerary spleens (HP:0009799)3.79133438
31Gait imbalance (HP:0002141)3.78776077
32Adactyly (HP:0009776)3.75134256
33Mixed hearing impairment (HP:0000410)3.69604590
34Nephrogenic diabetes insipidus (HP:0009806)3.68439215
35Medial flaring of the eyebrow (HP:0010747)3.67612121
36Neonatal death (HP:0003811)3.66899970
37Abnormality of the intervertebral disk (HP:0005108)3.61727630
38Heterotopia (HP:0002282)3.59588761
39Abnormality of the right ventricle (HP:0001707)3.48786309
40Rib fusion (HP:0000902)3.43460813
41Abnormality of the lacrimal duct (HP:0011481)3.40263331
42Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)3.40262397
43Bifid scrotum (HP:0000048)3.34514725
44Supernumerary ribs (HP:0005815)3.30638552
45Visceral angiomatosis (HP:0100761)3.27073224
46Aplasia/Hypoplasia of the scapulae (HP:0006713)3.27066671
47Hypoplastic scapulae (HP:0000882)3.27066671
48Germ cell neoplasia (HP:0100728)3.26337126
49Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)3.25172564
50Hemivertebrae (HP:0002937)3.23048555
51Leiomyosarcoma (HP:0100243)3.22440345
52Uterine leiomyosarcoma (HP:0002891)3.22440345
53Abnormal biliary tract physiology (HP:0012439)3.19525418
54Bile duct proliferation (HP:0001408)3.19525418
55Disproportionate short-trunk short stature (HP:0003521)3.18141622
56Absent radius (HP:0003974)3.13578935
57Absent forearm bone (HP:0003953)3.12169674
58Aplasia involving forearm bones (HP:0009822)3.12169674
59Abnormality of the antihelix (HP:0009738)3.11073022
60Poor coordination (HP:0002370)3.06828190
61Short femoral neck (HP:0100864)3.04087577
62Hemangiomatosis (HP:0007461)3.02109481
63Adrenal hypoplasia (HP:0000835)3.01886165
64Abnormal umbilical cord blood vessels (HP:0011403)2.99798195
65Single umbilical artery (HP:0001195)2.99798195
66Abnormality of the fetal cardiovascular system (HP:0010948)2.99798195
67Vaginal atresia (HP:0000148)2.96847431
68Abnormality of the nasolacrimal system (HP:0000614)2.96821790
69Supernumerary bones of the axial skeleton (HP:0009144)2.95735565
70Abnormality of permanent molar morphology (HP:0011071)2.94277526
71Abnormality of the dental root (HP:0006486)2.94277526
72Taurodontia (HP:0000679)2.94277526
73Breech presentation (HP:0001623)2.91521778
74Spinal canal stenosis (HP:0003416)2.88651857
75Abnormality of the musculature of the hand (HP:0001421)2.88378547
76Genital tract atresia (HP:0001827)2.85093766
77Broad hallux (HP:0010055)2.80594852
78Retinal dysplasia (HP:0007973)2.78554707
79Congenital malformation of the right heart (HP:0011723)2.77193766
80Double outlet right ventricle (HP:0001719)2.77193766
81Broad foot (HP:0001769)2.77157679
82Abnormality of molar (HP:0011077)2.73390992
83Abnormality of molar morphology (HP:0011070)2.73390992
84Preaxial foot polydactyly (HP:0001841)2.67429184
85Cortical dysplasia (HP:0002539)2.65706624
86Overfolded helix (HP:0000396)2.63533098
87Absent hand (HP:0004050)2.63203182
88Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.62700348
89Aplasia/Hypoplasia of the spleen (HP:0010451)2.62448259
90Transitional cell carcinoma of the bladder (HP:0006740)2.62331640
91Trigonocephaly (HP:0000243)2.60988605
92Abnormality of the dental pulp (HP:0006479)2.59070665
93Vitreoretinal degeneration (HP:0000655)2.58586114
94Asplenia (HP:0001746)2.57956098
95Abnormality of the incisor (HP:0000676)2.55072194
96Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.54120722
97Rectovaginal fistula (HP:0000143)2.52336412
98Rectal fistula (HP:0100590)2.52336412
99Camptodactyly of toe (HP:0001836)2.51964440
100Osteoarthritis (HP:0002758)2.51220904
101Gastrointestinal atresia (HP:0002589)2.50407697
102Tracheomalacia (HP:0002779)2.48225237
103Limited elbow extension (HP:0001377)2.47447759
104Abnormal mitochondria in muscle tissue (HP:0008316)2.41416194
105Aplasia/Hypoplasia of the lens (HP:0008063)2.41034426
106Abnormally folded helix (HP:0008544)2.40884803
107Cupped ear (HP:0000378)2.40725468
108Occipital encephalocele (HP:0002085)2.38500277
109Arterial tortuosity (HP:0005116)2.35205595
110Coarctation of aorta (HP:0001680)2.34983937
111Increased nuchal translucency (HP:0010880)2.34400964
112Limited hip movement (HP:0008800)2.34400586
113Broad toe (HP:0001837)2.34107397
114Spondylolisthesis (HP:0003302)2.31944399
115Bladder neoplasm (HP:0009725)2.31788977
116Bladder carcinoma (HP:0002862)2.31788977
117Skull defect (HP:0001362)2.29712699
118Neoplasm of the heart (HP:0100544)2.29678099
119Pancreatic cysts (HP:0001737)2.29480312
120Synostosis of carpal bones (HP:0005048)2.29446748
121Hypoplasia of the ulna (HP:0003022)2.29323695
122Meningocele (HP:0002435)2.25989172
123Acute necrotizing encephalopathy (HP:0006965)2.24657816
124Specific learning disability (HP:0001328)2.23910194
125Split hand (HP:0001171)2.23013003
126Underdeveloped supraorbital ridges (HP:0009891)2.22980261
127Abnormality of salivation (HP:0100755)2.21661521
128Ependymoma (HP:0002888)2.19693113
129Vertebral fusion (HP:0002948)2.18484275
130Neoplasm of striated muscle (HP:0009728)2.17900909
131Rimmed vacuoles (HP:0003805)2.16301865
132Protrusio acetabuli (HP:0003179)2.15749447
133Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)2.14904750
134True hermaphroditism (HP:0010459)2.14814187
135Decreased testicular size (HP:0008734)2.13634220
136Intestinal fistula (HP:0100819)2.13224133
137Hepatoblastoma (HP:0002884)2.11768130
138Thyroid-stimulating hormone excess (HP:0002925)2.09211049
139Aplasia/hypoplasia of the femur (HP:0005613)2.08784465
140Vaginal fistula (HP:0004320)2.07968016
141Postaxial hand polydactyly (HP:0001162)2.07144757
142Plagiocephaly (HP:0001357)2.04680125
143Vascular tortuosity (HP:0004948)2.04426613
144Esophageal atresia (HP:0002032)2.02864368
145Acute encephalopathy (HP:0006846)2.02826384
146Short middle phalanx of finger (HP:0005819)2.02427605
147Split foot (HP:0001839)2.02200419
148Joint contractures involving the joints of the feet (HP:0100492)2.01771400
149Flexion contracture of toe (HP:0005830)2.01771400
150Limb dystonia (HP:0002451)2.01610935
151Aplasia/Hypoplasia of the earlobes (HP:0009906)2.01484682
152Renal hypoplasia (HP:0000089)2.01337572
153Esophageal varix (HP:0002040)2.00991967
154Deviation of the hallux (HP:0010051)2.00296354
155Hallux valgus (HP:0001822)1.99985997
156Increased number of teeth (HP:0011069)1.99168421
157Acanthosis nigricans (HP:0000956)1.98711866
158Pancreatic fibrosis (HP:0100732)1.96872105
159Omphalocele (HP:0001539)1.96688689
160Porencephaly (HP:0002132)1.95801423
161Hypoplasia of the radius (HP:0002984)1.95026407
162Arnold-Chiari malformation (HP:0002308)1.94530223
163Flared metaphyses (HP:0003015)1.94462473
164Abnormality of the labia minora (HP:0012880)1.94201395
165Malignant gastrointestinal tract tumors (HP:0006749)1.94106384
166Gastrointestinal carcinoma (HP:0002672)1.94106384
167Renal cell carcinoma (HP:0005584)1.94034542
168Abnormality of the epiphyses of the hand (HP:0005924)1.93440829
169Polymicrogyria (HP:0002126)1.91669929
170Tarsal synostosis (HP:0008368)1.91219788
171Bilateral microphthalmos (HP:0007633)1.90320177
172Cutaneous finger syndactyly (HP:0010554)1.89703982
173Narrow nasal bridge (HP:0000446)1.88235824
174Myelomeningocele (HP:0002475)1.87742107
175Low anterior hairline (HP:0000294)1.86711006
176Congenital sensorineural hearing impairment (HP:0008527)1.85150450
177Partial agenesis of the corpus callosum (HP:0001338)1.85060397
178Advanced eruption of teeth (HP:0006288)1.84094653
179Anencephaly (HP:0002323)1.82319767
180Cutaneous syndactyly (HP:0012725)1.81880895
181Large earlobe (HP:0009748)1.81190700
182Spina bifida occulta (HP:0003298)1.79459317
183Abnormality of the aortic arch (HP:0012303)1.78544304
184Anophthalmia (HP:0000528)1.78222760
185Chorioretinal coloboma (HP:0000567)1.77838832
186Broad forehead (HP:0000337)1.77132172
187Anal atresia (HP:0002023)1.74069834
188Preaxial hand polydactyly (HP:0001177)1.72353740
189Pheochromocytoma (HP:0002666)1.71635169
190Rhabdomyosarcoma (HP:0002859)1.70798203
191Methylmalonic acidemia (HP:0002912)1.70695272
192Increased intracranial pressure (HP:0002516)1.70222713
193Abnormality of intracranial pressure (HP:0012640)1.70222713
194Myopathic facies (HP:0002058)1.69676390
195Depressed nasal ridge (HP:0000457)1.68614439
196Abnormality of the umbilical cord (HP:0010881)1.67770789

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FGFR36.92564400
2CDK84.08637948
3PBK3.60637491
4SRPK13.57888301
5TRIM283.36491535
6FGFR13.30329116
7MST42.54141144
8VRK22.48594867
9CDC72.48398129
10TLK12.40421192
11MELK2.03296611
12BUB112.9287668
13MAP3K41.96328041
14MAP3K71.84329546
15PKN11.82119528
16DYRK1B1.74652056
17MAP2K71.66081575
18MAP4K21.56552032
19UHMK11.56050486
20CDK91.52805499
21EPHB21.51634482
22NEK11.49127226
23ROCK21.48552815
24NEK21.46753649
25CASK1.46654457
26MKNK11.40262597
27BCKDK1.40080840
28CDK191.26769959
29PRKCZ1.24945060
30ARAF1.23507013
31ADRBK21.21106926
32DYRK31.15803493
33CAMK11.14770023
34CSNK1G31.12146328
35BLK1.09911142
36LRRK21.09530360
37PLK21.04162520
38ROCK11.03576719
39STK160.99293495
40CSNK1A1L0.97520245
41KSR10.96012502
42CSNK1G10.94569693
43MAP3K100.93380798
44PINK10.81587275
45MET0.81431066
46CSNK1G20.81401442
47VRK10.78310744
48PAK40.77029581
49CDK40.75629673
50AKT20.71938381
51STK100.70237873
52TXK0.67144407
53MAPK90.65805087
54EGFR0.65245111
55PRKD30.62595046
56GRK60.59818317
57EPHA30.59724813
58MAPK100.59689995
59NEK60.59173164
60OBSCN0.59064596
61SIK30.56163130
62CLK10.54518120
63ADRBK10.53113255
64MAP2K40.52655374
65PLK10.52177233
66CDK180.51884968
67CAMK40.51512799
68TSSK60.50689137
69IGF1R0.50374084
70TAF10.49075093
71PLK30.48925825
72CAMK2A0.48881508
73PDK20.48875817
74CSNK1D0.48421340
75TTK0.48340137
76CDK150.47170782
77OXSR10.46514528
78EEF2K0.46313805
79ILK0.46285771
80CDK60.45442547
81PRKD20.44797759
82BMPR1B0.44182999
83PRKAA10.43683379
84PTK2B0.43273982
85STK40.42418500
86CDK70.40922245
87CDK11A0.40360720
88CSK0.39640903
89DMPK0.39380477
90NME10.39312126
91BCR0.38725907
92PRKCG0.38028437
93SGK2230.37251080
94SGK4940.37251080
95PRKCI0.36908991
96PAK60.36015603
97MINK10.35551381
98CDK140.34729079
99CHEK20.34159533
100FGFR40.34108302
101MKNK20.33096972
102WNK30.32820123
103PTK20.32453765
104FGR0.31483380
105PRKCE0.30548217
106STK110.30482075
107GSK3B0.29560359
108ERBB20.29256232
109MTOR0.27189782
110MARK10.25864905
111AURKB0.25813910
112ERBB30.23789725
113NTRK30.22791877
114ATR0.22333783
115BRD40.19998629
116SGK10.18817816
117CDK50.18758730
118IRAK30.18645227
119AURKA0.18166486
120CHEK10.18094116
121NUAK10.17511351
122BTK0.16995225
123SIK20.16082694
124MAPKAPK30.16078501
125ERN10.15453594
126PRKCB0.15284378
127CDK20.15267868
128PRKACG0.14502120
129EIF2AK10.14424676
130PRKAA20.14092978
131FGFR20.13951536
132PRKCD0.13500641
133TNIK0.12902582
134PRKG20.12814854
135BMX0.12349743
136PRKACB0.12267620
137RAF10.11984993
138SCYL20.11838105
139CDK10.10290007
140FYN0.10153387
141RPS6KA30.10033088
142SRC0.09511758
143DAPK10.09139569
144PRKCA0.08771969
145ALK0.08584729
146DYRK1A0.08011847
147NTRK20.07231239
148LIMK10.07154551
149DYRK20.07125353
150TTN0.05987922
151KIT0.05979770
152MOS0.05410365
153RPS6KB20.05357756
154EPHA40.02659123
155PDGFRA0.02379215
156YES10.02131763
157PAK30.02069897
158CAMK1D0.01744201
159INSR0.01615470

Predicted pathways (KEGG)

RankGene SetZ-score
1Notch signaling pathway_Homo sapiens_hsa043306.68426700
2Dorso-ventral axis formation_Homo sapiens_hsa043205.10498791
3Basal cell carcinoma_Homo sapiens_hsa052174.76883500
4Hedgehog signaling pathway_Homo sapiens_hsa043404.60581543
5Bladder cancer_Homo sapiens_hsa052193.92090510
6Prion diseases_Homo sapiens_hsa050203.86154775
7Parkinsons disease_Homo sapiens_hsa050123.32005760
8Ribosome_Homo sapiens_hsa030103.15983844
9Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005343.09880829
10Oxidative phosphorylation_Homo sapiens_hsa001902.87524828
11Vitamin B6 metabolism_Homo sapiens_hsa007502.78882312
12Proteasome_Homo sapiens_hsa030502.78157941
13Mismatch repair_Homo sapiens_hsa034302.63344649
14Central carbon metabolism in cancer_Homo sapiens_hsa052302.38695448
15Primary bile acid biosynthesis_Homo sapiens_hsa001202.34935897
16Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.34363260
17RNA polymerase_Homo sapiens_hsa030202.33107860
18Non-homologous end-joining_Homo sapiens_hsa034502.18433480
19Huntingtons disease_Homo sapiens_hsa050162.04324597
20Base excision repair_Homo sapiens_hsa034102.03545521
21Propanoate metabolism_Homo sapiens_hsa006402.01876566
22MicroRNAs in cancer_Homo sapiens_hsa052062.00433999
23RNA degradation_Homo sapiens_hsa030181.88749635
24Nitrogen metabolism_Homo sapiens_hsa009101.84666740
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.83773882
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.71983981
27Hippo signaling pathway_Homo sapiens_hsa043901.64737168
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.51625268
29Lysine degradation_Homo sapiens_hsa003101.42280188
30Steroid biosynthesis_Homo sapiens_hsa001001.40879122
31Axon guidance_Homo sapiens_hsa043601.29361924
32Thyroid hormone signaling pathway_Homo sapiens_hsa049191.23356839
33Wnt signaling pathway_Homo sapiens_hsa043101.22013856
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.18328574
35mRNA surveillance pathway_Homo sapiens_hsa030151.16297708
36Homologous recombination_Homo sapiens_hsa034401.15621511
37Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.15473854
38Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.14526124
39Fatty acid elongation_Homo sapiens_hsa000621.14340856
40Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.14190054
41Melanogenesis_Homo sapiens_hsa049161.13742339
42Circadian rhythm_Homo sapiens_hsa047101.10445236
43Peroxisome_Homo sapiens_hsa041461.09033636
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.07909671
45Tight junction_Homo sapiens_hsa045301.04576042
46Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.02618908
47HTLV-I infection_Homo sapiens_hsa051661.02587293
48Pathways in cancer_Homo sapiens_hsa052001.00554792
49alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.00139254
50Cholinergic synapse_Homo sapiens_hsa047250.98888019
51Proteoglycans in cancer_Homo sapiens_hsa052050.98324230
52Spliceosome_Homo sapiens_hsa030400.97508398
53Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.97282742
54Oocyte meiosis_Homo sapiens_hsa041140.94710510
55Alcoholism_Homo sapiens_hsa050340.92358917
56Cocaine addiction_Homo sapiens_hsa050300.92119249
57Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.90786139
58Gap junction_Homo sapiens_hsa045400.82854186
59Colorectal cancer_Homo sapiens_hsa052100.81575041
60Rap1 signaling pathway_Homo sapiens_hsa040150.81549434
61Cell cycle_Homo sapiens_hsa041100.77000336
62Morphine addiction_Homo sapiens_hsa050320.75990781
63Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.75615199
64p53 signaling pathway_Homo sapiens_hsa041150.74683076
65DNA replication_Homo sapiens_hsa030300.72309191
66Arginine biosynthesis_Homo sapiens_hsa002200.71961005
67Endocytosis_Homo sapiens_hsa041440.71867082
68TGF-beta signaling pathway_Homo sapiens_hsa043500.68272262
69Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.67406351
70Regulation of actin cytoskeleton_Homo sapiens_hsa048100.67290720
71Cysteine and methionine metabolism_Homo sapiens_hsa002700.65922201
72N-Glycan biosynthesis_Homo sapiens_hsa005100.65580094
73Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.65526554
74Pyrimidine metabolism_Homo sapiens_hsa002400.64757750
75Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.61006985
76Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.60886346
77Purine metabolism_Homo sapiens_hsa002300.60441023
78Circadian entrainment_Homo sapiens_hsa047130.59806474
79Taste transduction_Homo sapiens_hsa047420.56042046
80Ras signaling pathway_Homo sapiens_hsa040140.54306229
81Complement and coagulation cascades_Homo sapiens_hsa046100.54283643
82Nucleotide excision repair_Homo sapiens_hsa034200.53972754
83Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.53386713
84Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.52916767
85beta-Alanine metabolism_Homo sapiens_hsa004100.52432957
86RNA transport_Homo sapiens_hsa030130.51533598
87Collecting duct acid secretion_Homo sapiens_hsa049660.49628599
88Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.48529469
89Phototransduction_Homo sapiens_hsa047440.48134635
90AMPK signaling pathway_Homo sapiens_hsa041520.46789341
91Serotonergic synapse_Homo sapiens_hsa047260.46571797
92Folate biosynthesis_Homo sapiens_hsa007900.45017985
93Pyruvate metabolism_Homo sapiens_hsa006200.44881322
94Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.44391024
95Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.44046609
96Histidine metabolism_Homo sapiens_hsa003400.44038541
97Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.43670374
98AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.42603213
99Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.41813897
100Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.41198149
101Regulation of autophagy_Homo sapiens_hsa041400.40924228
102Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.40878190
103Protein export_Homo sapiens_hsa030600.40228904
104Metabolic pathways_Homo sapiens_hsa011000.40108695
105Pancreatic cancer_Homo sapiens_hsa052120.39942418
106Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.39241929
107Dopaminergic synapse_Homo sapiens_hsa047280.38920455
108Oxytocin signaling pathway_Homo sapiens_hsa049210.38823838
109Inositol phosphate metabolism_Homo sapiens_hsa005620.38369519
110Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.38181219
111Calcium signaling pathway_Homo sapiens_hsa040200.38126974
112Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.37910230
113Olfactory transduction_Homo sapiens_hsa047400.37181790
114Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.36530867
115Chronic myeloid leukemia_Homo sapiens_hsa052200.35315711
116Arginine and proline metabolism_Homo sapiens_hsa003300.35309995
117Pentose and glucuronate interconversions_Homo sapiens_hsa000400.35270413
118GABAergic synapse_Homo sapiens_hsa047270.35239722
119Basal transcription factors_Homo sapiens_hsa030220.35237988
120PI3K-Akt signaling pathway_Homo sapiens_hsa041510.34876973
121Phenylalanine metabolism_Homo sapiens_hsa003600.34758921
122Glutamatergic synapse_Homo sapiens_hsa047240.33684860
123Tryptophan metabolism_Homo sapiens_hsa003800.33494640
124Dilated cardiomyopathy_Homo sapiens_hsa054140.32399491
125Apoptosis_Homo sapiens_hsa042100.32343946
126Adherens junction_Homo sapiens_hsa045200.30954707
127Biosynthesis of amino acids_Homo sapiens_hsa012300.30687578
128Renin secretion_Homo sapiens_hsa049240.28149505
129Bile secretion_Homo sapiens_hsa049760.27526151
130Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.26656243
131Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.25745315
132Long-term depression_Homo sapiens_hsa047300.25548751
133Nicotine addiction_Homo sapiens_hsa050330.24819496
134Alzheimers disease_Homo sapiens_hsa050100.24747684
135Salivary secretion_Homo sapiens_hsa049700.24543227
136MAPK signaling pathway_Homo sapiens_hsa040100.22572683
137PPAR signaling pathway_Homo sapiens_hsa033200.22289235
138Type I diabetes mellitus_Homo sapiens_hsa049400.22032675
139Butanoate metabolism_Homo sapiens_hsa006500.21348711
140Selenocompound metabolism_Homo sapiens_hsa004500.20725242
141Maturity onset diabetes of the young_Homo sapiens_hsa049500.18708844
142Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.18686778
143Synaptic vesicle cycle_Homo sapiens_hsa047210.18639375
144Vascular smooth muscle contraction_Homo sapiens_hsa042700.17668798
145Focal adhesion_Homo sapiens_hsa045100.17421620
146Staphylococcus aureus infection_Homo sapiens_hsa051500.17307112
147Fatty acid metabolism_Homo sapiens_hsa012120.17268201
148Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.17094945
149Glucagon signaling pathway_Homo sapiens_hsa049220.17044341
150Cardiac muscle contraction_Homo sapiens_hsa042600.16518243
151cAMP signaling pathway_Homo sapiens_hsa040240.16163779
152Chemical carcinogenesis_Homo sapiens_hsa052040.13340377
153Viral carcinogenesis_Homo sapiens_hsa052030.12657803
154Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.11944288
155Fanconi anemia pathway_Homo sapiens_hsa034600.11581887
156Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.11035486

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