DBX2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1alanine transport (GO:0032328)7.44520419
2L-serine transport (GO:0015825)6.50788006
3L-amino acid import (GO:0043092)6.46030230
4amino acid import (GO:0043090)6.36337479
5presynaptic membrane assembly (GO:0097105)6.23577210
6serine transport (GO:0032329)5.69996105
7presynaptic membrane organization (GO:0097090)5.38277806
8C4-dicarboxylate transport (GO:0015740)5.35403791
9negative regulation of inclusion body assembly (GO:0090084)5.12045066
10axon ensheathment in central nervous system (GO:0032291)4.84666091
11central nervous system myelination (GO:0022010)4.84666091
12low-density lipoprotein particle remodeling (GO:0034374)4.78221596
13regulation of inclusion body assembly (GO:0090083)4.76660397
14negative regulation of astrocyte differentiation (GO:0048712)4.74087337
15cellular potassium ion homeostasis (GO:0030007)4.67740092
16negative regulation of synaptic transmission, glutamatergic (GO:0051967)4.65372402
17neuronal action potential propagation (GO:0019227)4.58001849
18neurotransmitter uptake (GO:0001504)4.56875475
19photoreceptor cell differentiation (GO:0046530)4.56412278
20eye photoreceptor cell differentiation (GO:0001754)4.56412278
21mechanosensory behavior (GO:0007638)4.32781886
22cell communication by electrical coupling (GO:0010644)4.30828625
23sodium ion export (GO:0071436)4.29468010
24G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.24817372
25regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.23792942
26gamma-aminobutyric acid transport (GO:0015812)4.21880514
27chondroitin sulfate catabolic process (GO:0030207)4.12870810
28astrocyte differentiation (GO:0048708)4.08811350
29adenine nucleotide transport (GO:0051503)4.08415766
30negative regulation of oligodendrocyte differentiation (GO:0048715)4.02777546
31long-chain fatty acid biosynthetic process (GO:0042759)4.01765872
32cGMP-mediated signaling (GO:0019934)3.97640372
33acidic amino acid transport (GO:0015800)3.95143997
34negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.91006048
35neurotransmitter-gated ion channel clustering (GO:0072578)3.90996963
36regulation of phospholipid biosynthetic process (GO:0071071)3.89892281
37glutamate receptor signaling pathway (GO:0007215)3.84894628
38cellular sodium ion homeostasis (GO:0006883)3.82246234
39positive regulation of cellular amide metabolic process (GO:0034250)3.81270326
40locomotory exploration behavior (GO:0035641)3.76807159
41potassium ion import (GO:0010107)3.72392051
42proline transport (GO:0015824)3.69725775
43cochlea development (GO:0090102)3.67635984
44membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.63844344
45pyrimidine nucleobase catabolic process (GO:0006208)3.63087313
46cerebral cortex radially oriented cell migration (GO:0021799)3.60231038
47atrial cardiac muscle cell action potential (GO:0086014)3.59397066
48axon regeneration (GO:0031103)3.57193181
49negative regulation of sodium ion transport (GO:0010766)3.54429292
50purine nucleotide transport (GO:0015865)3.52622620
51regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.52291436
52vocalization behavior (GO:0071625)3.44648199
53neuron projection regeneration (GO:0031102)3.44057368
54negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.43261915
55regulation of short-term neuronal synaptic plasticity (GO:0048172)3.42609705
56regulation of synapse structural plasticity (GO:0051823)3.41192605
57astrocyte development (GO:0014002)3.40819762
58ionotropic glutamate receptor signaling pathway (GO:0035235)3.39841569
59negative regulation of synaptic transmission, GABAergic (GO:0032229)3.38862021
60limb bud formation (GO:0060174)3.38724017
61heart valve formation (GO:0003188)3.38160199
62otic vesicle formation (GO:0030916)3.37232965
63L-glutamate transport (GO:0015813)3.35470952
64cellular response to cholesterol (GO:0071397)3.33982708
65regulation of synaptic transmission, glutamatergic (GO:0051966)3.33032543
66Sertoli cell development (GO:0060009)3.30182872
67synaptic vesicle docking involved in exocytosis (GO:0016081)3.30070145
68neuron cell-cell adhesion (GO:0007158)3.28957452
69dermatan sulfate metabolic process (GO:0030205)3.25398002
70dermatan sulfate biosynthetic process (GO:0030208)3.24716317
71regulation of respiratory system process (GO:0044065)3.23070959
72potassium ion homeostasis (GO:0055075)3.22963058
73axonal fasciculation (GO:0007413)3.21751807
74protein localization to synapse (GO:0035418)3.18656654
75axon development (GO:0061564)3.17154602
76neuron recognition (GO:0008038)3.16895483
77regulation of beta-amyloid formation (GO:1902003)3.14872469
78regulation of astrocyte differentiation (GO:0048710)3.12647036
79oligodendrocyte differentiation (GO:0048709)3.11764438
80negative regulation of smoothened signaling pathway (GO:0045879)3.11563464
81positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.11356099
82synaptic transmission, glutamatergic (GO:0035249)3.09965205
83cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.09762409
84positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.09011958
85membrane repolarization (GO:0086009)3.08918010
86hair follicle development (GO:0001942)3.08259376
87auditory behavior (GO:0031223)3.05058448
88regulation of heat generation (GO:0031650)3.04105484
89regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.00133404
90response to auditory stimulus (GO:0010996)2.97791619
91regulation of neurotransmitter uptake (GO:0051580)2.97564779
92transmission of nerve impulse (GO:0019226)2.96562472
93nonmotile primary cilium assembly (GO:0035058)2.95624454
94positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.95486636
95regulation of membrane repolarization (GO:0060306)2.94633615
96ovulation cycle (GO:0042698)2.94543597
97startle response (GO:0001964)2.94206756
98synaptic vesicle exocytosis (GO:0016079)2.94107251
99dendritic spine morphogenesis (GO:0060997)2.92148229
100regulation of amyloid precursor protein catabolic process (GO:1902991)2.91879011
101regulation of long-term neuronal synaptic plasticity (GO:0048169)2.91467056
102negative regulation of glial cell differentiation (GO:0045686)2.89954697
103cellular response to sterol (GO:0036315)2.89666122
104purine ribonucleotide transport (GO:0015868)2.88336392
105myelination in peripheral nervous system (GO:0022011)2.86595427
106peripheral nervous system axon ensheathment (GO:0032292)2.86595427
107regulation of respiratory gaseous exchange (GO:0043576)2.86436138
108telencephalon development (GO:0021537)2.85700104
109positive regulation of potassium ion transmembrane transport (GO:1901381)2.85229052
110regulation of neuronal synaptic plasticity (GO:0048168)2.84933700
111regulation of sensory perception (GO:0051931)2.84902411
112regulation of sensory perception of pain (GO:0051930)2.84902411
113regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.84508444
114cell-cell junction maintenance (GO:0045217)2.83556948
115nucleobase catabolic process (GO:0046113)2.82801740
116fatty acid elongation (GO:0030497)2.82562394
117L-amino acid transport (GO:0015807)2.81323751
118nephron tubule formation (GO:0072079)2.80728155
119synaptic vesicle maturation (GO:0016188)2.79912084
120membrane assembly (GO:0071709)2.79748975
121positive regulation of male gonad development (GO:2000020)2.79112674
122regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.78753262
123regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.75638571
124axon ensheathment (GO:0008366)2.74944468
125ensheathment of neurons (GO:0007272)2.74944468
126lens fiber cell development (GO:0070307)2.73901988
127positive regulation of catecholamine secretion (GO:0033605)2.73160067
128cardiac left ventricle morphogenesis (GO:0003214)2.72512487
129neurotransmitter secretion (GO:0007269)2.72019934
130glial cell proliferation (GO:0014009)2.71513141
131cholesterol catabolic process (GO:0006707)2.71427444
132sterol catabolic process (GO:0016127)2.71427444
133postsynaptic membrane organization (GO:0001941)2.70842892
134response to dietary excess (GO:0002021)2.69344273
135regulation of cholesterol esterification (GO:0010872)2.66556588
136glutamate secretion (GO:0014047)2.66498749
137regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.65279303
138vascular smooth muscle contraction (GO:0014829)2.64514336
139negative regulation of cytosolic calcium ion concentration (GO:0051481)2.63854528
140detection of temperature stimulus (GO:0016048)2.63038445
141chondroitin sulfate biosynthetic process (GO:0030206)2.62859876
142positive regulation of sodium ion transmembrane transport (GO:1902307)2.62254479
143regulation of cardiac muscle cell contraction (GO:0086004)2.60995885
144L-fucose catabolic process (GO:0042355)2.60889173
145fucose catabolic process (GO:0019317)2.60889173
146L-fucose metabolic process (GO:0042354)2.60889173
147cerebellar granule cell differentiation (GO:0021707)2.60817655
148exploration behavior (GO:0035640)2.60736979
149neuron-neuron synaptic transmission (GO:0007270)2.59606503
150myelination (GO:0042552)2.59344654
151regulation of glutamate receptor signaling pathway (GO:1900449)2.55686956
152layer formation in cerebral cortex (GO:0021819)2.54937124
153positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.54157654

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.53906200
2GBX2_23144817_ChIP-Seq_PC3_Human3.33980480
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.33012178
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.12632275
5* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.03027785
6EZH2_27304074_Chip-Seq_ESCs_Mouse2.77050510
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.76631788
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.76631788
9SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.73321967
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.68594108
11SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.66408029
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.60495843
13AR_21572438_ChIP-Seq_LNCaP_Human2.58653076
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.52320088
15EED_16625203_ChIP-ChIP_MESCs_Mouse2.49540525
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.47308374
17RNF2_27304074_Chip-Seq_ESCs_Mouse2.36103687
18* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.31099307
19EZH2_27294783_Chip-Seq_ESCs_Mouse2.22341474
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.21125894
21HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.13815284
22DROSHA_22980978_ChIP-Seq_HELA_Human2.13562407
23* REST_21632747_ChIP-Seq_MESCs_Mouse2.02370000
24RBPJ_22232070_ChIP-Seq_NCS_Mouse1.96373115
25CBX2_27304074_Chip-Seq_ESCs_Mouse1.86651795
26CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.86511775
27AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.74125781
28RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.71013354
29CTBP1_25329375_ChIP-Seq_LNCAP_Human1.70021390
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.66992384
31RING1B_27294783_Chip-Seq_ESCs_Mouse1.63043835
32POU5F1_16153702_ChIP-ChIP_HESCs_Human1.59583329
33IKZF1_21737484_ChIP-ChIP_HCT116_Human1.58308719
34GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.57235201
35P300_19829295_ChIP-Seq_ESCs_Human1.55999226
36PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.55169999
37ZFP57_27257070_Chip-Seq_ESCs_Mouse1.54545141
38IGF1R_20145208_ChIP-Seq_DFB_Human1.53393610
39SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49870234
40RARB_27405468_Chip-Seq_BRAIN_Mouse1.46874957
41PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.43553232
42REST_18959480_ChIP-ChIP_MESCs_Mouse1.42541142
43LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38970448
44RNF2_27304074_Chip-Seq_NSC_Mouse1.37931146
45TP53_20018659_ChIP-ChIP_R1E_Mouse1.37389758
46YAP1_20516196_ChIP-Seq_MESCs_Mouse1.36765208
47PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.36300884
48PIAS1_25552417_ChIP-Seq_VCAP_Human1.35855985
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.35531055
50TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.35341862
51GATA1_26923725_Chip-Seq_HPCs_Mouse1.33635972
52SMAD4_21799915_ChIP-Seq_A2780_Human1.33177387
53EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.32278053
54CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30867099
55BCAT_22108803_ChIP-Seq_LS180_Human1.30043722
56SOX9_26525672_Chip-Seq_HEART_Mouse1.27781270
57HTT_18923047_ChIP-ChIP_STHdh_Human1.27642942
58AR_25329375_ChIP-Seq_VCAP_Human1.27622456
59SMAD_19615063_ChIP-ChIP_OVARY_Human1.26978785
60* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.26873898
61RXR_22108803_ChIP-Seq_LS180_Human1.25323410
62SALL1_21062744_ChIP-ChIP_HESCs_Human1.23207267
63OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22481508
64NR3C1_23031785_ChIP-Seq_PC12_Mouse1.21826228
65SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20643509
66ZNF274_21170338_ChIP-Seq_K562_Hela1.19870924
67JUN_21703547_ChIP-Seq_K562_Human1.18914449
68TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17690093
69POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.17690093
70STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.17534198
71RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.16237612
72CDX2_19796622_ChIP-Seq_MESCs_Mouse1.16148564
73CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.15785494
74LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14888380
75NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.14280851
76TP53_18474530_ChIP-ChIP_U2OS_Human1.13746638
77UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13684379
78SOX2_21211035_ChIP-Seq_LN229_Gbm1.12791547
79TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12324414
80* RING1B_27294783_Chip-Seq_NPCs_Mouse1.11985592
81MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.11857945
82ERG_21242973_ChIP-ChIP_JURKAT_Human1.11657445
83PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.10904035
84EWS_26573619_Chip-Seq_HEK293_Human1.10347943
85MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.09242911
86ESR1_15608294_ChIP-ChIP_MCF-7_Human1.08854561
87NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08829775
88FUS_26573619_Chip-Seq_HEK293_Human1.06771615
89ER_23166858_ChIP-Seq_MCF-7_Human1.06619273
90TCF4_23295773_ChIP-Seq_U87_Human1.05728681
91* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.04072973
92CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.02819296
93ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.02027340
94DNAJC2_21179169_ChIP-ChIP_NT2_Human1.01051414
95TAF15_26573619_Chip-Seq_HEK293_Human1.00309447
96ZNF217_24962896_ChIP-Seq_MCF-7_Human0.99261200
97EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.98988221
98POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.98268013
99WT1_25993318_ChIP-Seq_PODOCYTE_Human0.98148269
100* TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98141900
101NRF2_20460467_ChIP-Seq_MEFs_Mouse0.97965361
102NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.97965361
103VDR_22108803_ChIP-Seq_LS180_Human0.97616755
104SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.97572932
105* AR_19668381_ChIP-Seq_PC3_Human0.95515188
106SMAD3_21741376_ChIP-Seq_ESCs_Human0.93093205
107* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.92450418
108ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.91780352
109TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91278100
110NANOG_18555785_Chip-Seq_ESCs_Mouse0.90940967
111TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.90585127
112* RUNX2_22187159_ChIP-Seq_PCA_Human0.90306264
113TRIM28_21343339_ChIP-Seq_HEK293_Human0.87563657
114BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.87332777
115THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.86347053
116BMI1_23680149_ChIP-Seq_NPCS_Mouse0.86240568
117EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.85848232
118KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.85589273
119PRDM14_20953172_ChIP-Seq_ESCs_Human0.84548768
120TP53_16413492_ChIP-PET_HCT116_Human0.84545676
121P53_22127205_ChIP-Seq_FIBROBLAST_Human0.84472973
122STAT3_23295773_ChIP-Seq_U87_Human0.84192048
123OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.83609191
124E2F1_18555785_Chip-Seq_ESCs_Mouse0.83209348
125MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.82968428

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color5.08540802
2MP0003690_abnormal_glial_cell3.63753219
3MP0004885_abnormal_endolymph3.48252931
4MP0004859_abnormal_synaptic_plasticity3.39492990
5MP0005423_abnormal_somatic_nervous3.05945397
6MP0001486_abnormal_startle_reflex2.97678951
7MP0005171_absent_coat_pigmentation2.94472049
8MP0004270_analgesia2.82789633
9MP0003635_abnormal_synaptic_transmissio2.59970811
10MP0003329_amyloid_beta_deposits2.57360992
11MP0003878_abnormal_ear_physiology2.54428840
12MP0005377_hearing/vestibular/ear_phenot2.54428840
13MP0005646_abnormal_pituitary_gland2.50534516
14MP0002736_abnormal_nociception_after2.47786832
15MP0002254_reproductive_system_inflammat2.45991177
16MP0009745_abnormal_behavioral_response2.41491044
17MP0002064_seizures2.35020820
18MP0004858_abnormal_nervous_system2.30162477
19MP0001968_abnormal_touch/_nociception2.29131114
20MP0009384_cardiac_valve_regurgitation2.26942838
21MP0003880_abnormal_central_pattern2.22849392
22MP0002063_abnormal_learning/memory/cond2.14208401
23MP0009046_muscle_twitch2.09265448
24MP0002572_abnormal_emotion/affect_behav2.09118005
25MP0003787_abnormal_imprinting2.04632041
26MP0001485_abnormal_pinna_reflex2.00988451
27MP0001440_abnormal_grooming_behavior1.91592610
28MP0001502_abnormal_circadian_rhythm1.91295280
29MP0003634_abnormal_glial_cell1.81146636
30MP0000566_synostosis1.76985880
31MP0005409_darkened_coat_color1.76521713
32MP0002272_abnormal_nervous_system1.75081991
33MP0003633_abnormal_nervous_system1.74318117
34MP0002734_abnormal_mechanical_nocicepti1.61660735
35MP0009780_abnormal_chondrocyte_physiolo1.59352932
36MP0008569_lethality_at_weaning1.58162488
37MP0002735_abnormal_chemical_nociception1.54379305
38MP0002557_abnormal_social/conspecific_i1.53058236
39MP0001905_abnormal_dopamine_level1.50326426
40MP0001529_abnormal_vocalization1.47148994
41MP0004142_abnormal_muscle_tone1.46327607
42MP0005645_abnormal_hypothalamus_physiol1.43999899
43MP0002067_abnormal_sensory_capabilities1.43098064
44MP0001963_abnormal_hearing_physiology1.42068235
45MP0003631_nervous_system_phenotype1.40735520
46MP0000778_abnormal_nervous_system1.40666380
47MP0006072_abnormal_retinal_apoptosis1.40141031
48MP0003137_abnormal_impulse_conducting1.39731089
49MP0000569_abnormal_digit_pigmentation1.38980259
50MP0001501_abnormal_sleep_pattern1.38055515
51MP0001984_abnormal_olfaction1.37749866
52MP0002733_abnormal_thermal_nociception1.37006376
53MP0003075_altered_response_to1.33437325
54MP0000604_amyloidosis1.30452514
55MP0001970_abnormal_pain_threshold1.25278311
56MP0002095_abnormal_skin_pigmentation1.23201456
57MP0001986_abnormal_taste_sensitivity1.23028876
58MP0004215_abnormal_myocardial_fiber1.22866764
59MP0002089_abnormal_postnatal_growth/wei1.22708017
60MP0008877_abnormal_DNA_methylation1.20862707
61MP0000462_abnormal_digestive_system1.18088799
62MP0005551_abnormal_eye_electrophysiolog1.16880791
63MP0000026_abnormal_inner_ear1.15980551
64MP0000920_abnormal_myelination1.14223062
65MP0003632_abnormal_nervous_system1.14164522
66MP0003279_aneurysm1.13872386
67MP0003122_maternal_imprinting1.12882616
68MP0001853_heart_inflammation1.12309836
69MP0004811_abnormal_neuron_physiology1.11986618
70MP0002882_abnormal_neuron_morphology1.09063140
71MP0005167_abnormal_blood-brain_barrier1.07386693
72MP0005670_abnormal_white_adipose1.06067589
73MP0004742_abnormal_vestibular_system1.03265730
74MP0000579_abnormal_nail_morphology1.03107107
75MP0005386_behavior/neurological_phenoty1.01841845
76MP0004924_abnormal_behavior1.01841845
77MP0005187_abnormal_penis_morphology1.00422482
78MP0000049_abnormal_middle_ear0.99979251
79MP0006292_abnormal_olfactory_placode0.99174854
80MP0000751_myopathy0.98646787
81MP0005253_abnormal_eye_physiology0.98413320
82MP0006138_congestive_heart_failure0.97431353
83MP0000534_abnormal_ureter_morphology0.97176647
84MP0005379_endocrine/exocrine_gland_phen0.96898683
85MP0005248_abnormal_Harderian_gland0.96591055
86MP0003938_abnormal_ear_development0.96075510
87MP0002066_abnormal_motor_capabilities/c0.95643022
88MP0004133_heterotaxia0.93423844
89MP0000955_abnormal_spinal_cord0.91908945
90MP0002152_abnormal_brain_morphology0.91427707
91MP0001177_atelectasis0.90593647
92MP0003861_abnormal_nervous_system0.90484063
93MP0003950_abnormal_plasma_membrane0.89173435
94MP0003183_abnormal_peptide_metabolism0.89103153
95MP0009379_abnormal_foot_pigmentation0.88968807
96MP0002229_neurodegeneration0.88132195
97MP0003868_abnormal_feces_composition0.87216417
98MP0000631_abnormal_neuroendocrine_gland0.86393814
99MP0002249_abnormal_larynx_morphology0.85790908
100MP0002233_abnormal_nose_morphology0.84880718
101MP0002638_abnormal_pupillary_reflex0.84438811
102MP0003011_delayed_dark_adaptation0.82848886
103MP0005332_abnormal_amino_acid0.81958979
104MP0000428_abnormal_craniofacial_morphol0.78767965
105MP0005174_abnormal_tail_pigmentation0.78715712
106MP0005391_vision/eye_phenotype0.78623780
107MP0000762_abnormal_tongue_morphology0.75776470
108MP0002127_abnormal_cardiovascular_syste0.75453772
109MP0003121_genomic_imprinting0.75135771
110MP0008872_abnormal_physiological_respon0.73927047
111MP0003879_abnormal_hair_cell0.73138284
112MP0005647_abnormal_sex_gland0.73006937
113MP0002752_abnormal_somatic_nervous0.72601366
114MP0001958_emphysema0.72404850
115MP0006276_abnormal_autonomic_nervous0.71178245
116MP0005165_increased_susceptibility_to0.68255169
117MP0003755_abnormal_palate_morphology0.67520366
118MP0001664_abnormal_digestion0.66779569
119MP0002069_abnormal_eating/drinking_beha0.65420811
120MP0009250_abnormal_appendicular_skeleto0.65358464
121MP0008058_abnormal_DNA_repair0.64962633
122MP0005595_abnormal_vascular_smooth0.64935797
123MP0005499_abnormal_olfactory_system0.64235226
124MP0005394_taste/olfaction_phenotype0.64235226
125MP0005451_abnormal_body_composition0.63792691
126MP0002184_abnormal_innervation0.61425734
127MP0000647_abnormal_sebaceous_gland0.60367998
128MP0000372_irregular_coat_pigmentation0.59625302
129MP0005195_abnormal_posterior_eye0.59487909
130MP0004043_abnormal_pH_regulation0.59312008
131MP0002090_abnormal_vision0.58691205

Predicted human phenotypes

RankGene SetZ-score
1Aplasia involving bones of the extremities (HP:0009825)5.97139485
2Aplasia involving bones of the upper limbs (HP:0009823)5.97139485
3Aplasia of the phalanges of the hand (HP:0009802)5.97139485
4Abnormality of the axillary hair (HP:0100134)5.17980483
5Abnormality of secondary sexual hair (HP:0009888)5.17980483
6Hypoplastic left heart (HP:0004383)4.67179735
7Atonic seizures (HP:0010819)4.67111464
8Megalencephaly (HP:0001355)4.61306755
9Hemiparesis (HP:0001269)4.54067940
10Abnormality of binocular vision (HP:0011514)4.50954476
11Diplopia (HP:0000651)4.50954476
12Narrow nasal bridge (HP:0000446)3.89454008
13Neurofibrillary tangles (HP:0002185)3.88452618
14Split foot (HP:0001839)3.75666497
15Hepatoblastoma (HP:0002884)3.71137121
16Mixed hearing impairment (HP:0000410)3.69355163
17Hypoplastic heart (HP:0001961)3.61553206
18Hemiplegia (HP:0002301)3.58163079
19Focal motor seizures (HP:0011153)3.37679871
20Myokymia (HP:0002411)3.26036031
21Abnormality of the dental pulp (HP:0006479)3.19904406
22Cerebral inclusion bodies (HP:0100314)3.18198398
23Synostosis involving the elbow (HP:0003938)3.10382183
24Humeroradial synostosis (HP:0003041)3.10382183
25Onycholysis (HP:0001806)3.10310493
26Absence seizures (HP:0002121)3.07296597
27Morphological abnormality of the inner ear (HP:0011390)3.01002578
28Dialeptic seizures (HP:0011146)2.98031056
29Truncal ataxia (HP:0002078)2.95844357
30Oligodactyly (hands) (HP:0001180)2.88581849
31Focal seizures (HP:0007359)2.80782271
32Epileptic encephalopathy (HP:0200134)2.80433527
33Retinal dysplasia (HP:0007973)2.77971600
34Medulloblastoma (HP:0002885)2.75569352
35Colon cancer (HP:0003003)2.70543306
36Absent hair (HP:0002298)2.70519650
37Aplasia/Hypoplasia of the sternum (HP:0006714)2.65965958
38Facial shape deformation (HP:0011334)2.65253394
39Potter facies (HP:0002009)2.65253394
40Tracheomalacia (HP:0002779)2.60766344
41Clumsiness (HP:0002312)2.60682920
42True hermaphroditism (HP:0010459)2.57348976
43Septo-optic dysplasia (HP:0100842)2.57043090
44Degeneration of the lateral corticospinal tracts (HP:0002314)2.56331048
45Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.56331048
46Abnormality of nail color (HP:0100643)2.55498464
47Papillary thyroid carcinoma (HP:0002895)2.53424673
48Large for gestational age (HP:0001520)2.51363684
49Short middle phalanx of the 5th finger (HP:0004220)2.50147510
50Glioma (HP:0009733)2.46730889
51Astrocytoma (HP:0009592)2.44531493
52Abnormality of the astrocytes (HP:0100707)2.44531493
53Polyphagia (HP:0002591)2.42352180
54Neonatal short-limb short stature (HP:0008921)2.40855897
55Paraparesis (HP:0002385)2.40263474
56Confusion (HP:0001289)2.40007531
57Maternal diabetes (HP:0009800)2.39609038
58Slow-growing hair (HP:0002217)2.38864667
59Abnormality of hair growth rate (HP:0011363)2.38864667
60Tetraparesis (HP:0002273)2.37340684
61Fibular hypoplasia (HP:0003038)2.35435308
62Alacrima (HP:0000522)2.35000332
63Short hallux (HP:0010109)2.34437740
64Broad alveolar ridges (HP:0000187)2.34189302
65Long nose (HP:0003189)2.33832431
66Progressive cerebellar ataxia (HP:0002073)2.31624720
6711 pairs of ribs (HP:0000878)2.30191424
68Epidermoid cyst (HP:0200040)2.29831630
69Congenital sensorineural hearing impairment (HP:0008527)2.29527558
70Action tremor (HP:0002345)2.28765225
71Abnormality of the dental root (HP:0006486)2.28669844
72Taurodontia (HP:0000679)2.28669844
73Abnormality of permanent molar morphology (HP:0011071)2.28669844
74Urinary urgency (HP:0000012)2.25190607
75Renal tubular acidosis (HP:0001947)2.24337523
76Poor eye contact (HP:0000817)2.23735526
77Oligodactyly (HP:0012165)2.23365093
78Sex reversal (HP:0012245)2.20568800
79Abnormal sex determination (HP:0012244)2.20568800
80Supranuclear gaze palsy (HP:0000605)2.20342084
81Spastic paraparesis (HP:0002313)2.19908627
82Abnormality of the middle phalanges of the toes (HP:0010183)2.18445071
83Decreased lacrimation (HP:0000633)2.17968390
84Impaired vibration sensation in the lower limbs (HP:0002166)2.16401700
85Abnormality of the 4th metacarpal (HP:0010012)2.16001697
86Bronchomalacia (HP:0002780)2.14420251
87Abnormality of the corticospinal tract (HP:0002492)2.13861995
88Hypoplastic nipples (HP:0002557)2.13547312
89Abnormality of the diencephalon (HP:0010662)2.12934566
90Abnormality of molar (HP:0011077)2.11434766
91Abnormality of molar morphology (HP:0011070)2.11434766
92Neoplasm of the oral cavity (HP:0100649)2.11320242
93Aplasia/Hypoplasia of the hallux (HP:0008362)2.10312234
94Brittle hair (HP:0002299)2.07864808
95Abnormality of the ischium (HP:0003174)2.07709487
96Back pain (HP:0003418)2.07698951
97Cutaneous finger syndactyly (HP:0010554)2.06907403
98Generalized tonic-clonic seizures (HP:0002069)2.06669881
99Dysdiadochokinesis (HP:0002075)2.06278520
100Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.05536183
101Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.04441444
102Absent speech (HP:0001344)2.02914530
103Hypoplastic pelvis (HP:0008839)2.02863576
104Synostosis of carpal bones (HP:0005048)2.02827519
105Adactyly (HP:0009776)2.02455205
106Blue irides (HP:0000635)2.01874412
107Pseudobulbar signs (HP:0002200)2.01264402
108Renal dysplasia (HP:0000110)2.01100122
109Abnormality of magnesium homeostasis (HP:0004921)2.00809268
110Increased circulating renin level (HP:0000848)1.99620796
111Status epilepticus (HP:0002133)1.99275744
112Neoplasm of the adrenal cortex (HP:0100641)1.96516716
113Athetosis (HP:0002305)1.96003967
114Abnormal urine output (HP:0012590)1.95796525
115Multifactorial inheritance (HP:0001426)1.95631092
116Aplasia/Hypoplasia of the fibula (HP:0006492)1.95554157
117Optic nerve hypoplasia (HP:0000609)1.95332348
118Pheochromocytoma (HP:0002666)1.94238090
119Cortical dysplasia (HP:0002539)1.93278975
120Horizontal nystagmus (HP:0000666)1.92235965
121J-shaped sella turcica (HP:0002680)1.91697911
122Type II lissencephaly (HP:0007260)1.90593437
123White forelock (HP:0002211)1.90397215
124Scanning speech (HP:0002168)1.90019526
125Fibular aplasia (HP:0002990)1.89702158
126Abnormal eating behavior (HP:0100738)1.89080089
127Dry hair (HP:0011359)1.86788266
128Blepharitis (HP:0000498)1.86643580
129Abnormality of chromosome segregation (HP:0002916)1.86574497
130Cutaneous syndactyly (HP:0012725)1.86440110
131Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.86209036
132Vertebral hypoplasia (HP:0008417)1.86209036
133Postural instability (HP:0002172)1.85426933
134Drooling (HP:0002307)1.85273009
135Gait imbalance (HP:0002141)1.85141931
136Urinary bladder sphincter dysfunction (HP:0002839)1.84953872
137Peripheral hypomyelination (HP:0007182)1.84637826
138Abnormality of the phalanges of the 5th finger (HP:0004213)1.84301612
139Hyperventilation (HP:0002883)1.82398402
140Febrile seizures (HP:0002373)1.82090250
141Abnormality of the labia minora (HP:0012880)1.82000155
142Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.81948484
143Supernumerary ribs (HP:0005815)1.81757538
144Missing ribs (HP:0000921)1.81354533
145Vitreoretinal degeneration (HP:0000655)1.81217627
146Impaired social interactions (HP:0000735)1.80794638
147Abnormal social behavior (HP:0012433)1.80794638
148Patchy hypopigmentation of hair (HP:0011365)1.77632298
149Spastic gait (HP:0002064)1.76321672
150Gastrointestinal atresia (HP:0002589)1.76035624
151Genital tract atresia (HP:0001827)1.75952596
152Stereotypic behavior (HP:0000733)1.75870757
153Abnormal auditory evoked potentials (HP:0006958)1.75719791
154Abnormality of the columella (HP:0009929)1.74945891
155Termporal pattern (HP:0011008)1.74765657
156Insidious onset (HP:0003587)1.74765657
157Specific learning disability (HP:0001328)1.74719797
158Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.74084415
159Turricephaly (HP:0000262)1.73778338
160Abnormality of renal excretion (HP:0011036)1.72995105
161Follicular hyperkeratosis (HP:0007502)1.72554438
162Morphological abnormality of the middle ear (HP:0008609)1.71823337
163Esophageal atresia (HP:0002032)1.71689156
164Dementia (HP:0000726)1.68674741
165Thickened helices (HP:0000391)1.67690281
166Visual hallucinations (HP:0002367)1.67660170
167Hypoplasia of the iris (HP:0007676)1.67515464
168Abnormality of renal resorption (HP:0011038)1.67297839
169Supernumerary bones of the axial skeleton (HP:0009144)1.65462500

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK7.37403186
2PNCK5.22572857
3MKNK24.80277989
4LMTK24.16907308
5EPHA43.67125108
6MAPK153.65163749
7PHKG13.23972743
8PHKG23.23972743
9CASK2.49973532
10PRKD32.45975555
11MUSK2.42460473
12MAPKAPK52.36920869
13MKNK12.36243082
14NTRK22.19524033
15TSSK62.18523380
16MAPK132.00872477
17NTRK31.88820307
18MAP2K71.74941060
19MAP3K131.71342895
20CSNK1G21.66875561
21CCNB11.63911336
22ADRBK21.59513214
23MARK11.59367141
24MAPK121.56349536
25MAP3K91.55235945
26SGK21.40048679
27MAP3K41.37224509
28PRKCG1.36207029
29CSNK1A1L1.36028041
30ADRBK11.31160735
31SGK4941.29723184
32SGK2231.29723184
33CSNK1G31.26809855
34PLK21.19201209
35RIPK41.13539470
36FGR1.12688293
37CAMK1G1.11115445
38SGK31.09406672
39VRK11.09139681
40CSNK1G11.08710981
41MINK11.05929306
42DYRK20.98684625
43FES0.93167155
44NTRK10.93102055
45GRK50.92914025
46SIK20.92740648
47CDK50.90236215
48PKN10.85891219
49OXSR10.85352151
50WEE10.83958909
51EPHA30.83174577
52PRKCE0.82401903
53CAMK2A0.80890970
54EIF2AK10.77487953
55TNK20.75414750
56MAPK70.73913762
57PINK10.72336299
58CAMK10.72196912
59UHMK10.71831887
60TYRO30.68735437
61PRPF4B0.66779939
62KSR20.65967426
63PTK2B0.65564179
64WNK40.64636236
65DYRK1A0.63846991
66ERBB20.63245353
67WNK30.62787311
68ERBB40.60328808
69TRIM280.60185542
70ROCK10.57181112
71DAPK20.57059134
72ROCK20.56911203
73NEK60.56878187
74ARAF0.56445672
75PAK60.55388114
76STK390.53724811
77RAF10.53392309
78SGK10.52470584
79EPHB10.52224963
80CAMK2B0.51769077
81FGFR20.51656297
82PRKCA0.51246363
83TAOK30.51181705
84NUAK10.51033305
85CAMK2G0.51005663
86CAMKK20.50947482
87RIPK10.49283708
88CDK30.48992626
89MAP2K40.48776887
90PIK3CA0.48770331
91PRKD20.47731614
92CSNK1D0.46822430
93PRKG10.46737887
94TRIB30.46616766
95PBK0.45955738
96CSNK1A10.45448791
97EPHB20.45359868
98STK380.45258455
99MOS0.44850520
100BMPR1B0.44789495
101PRKACA0.44098723
102WNK10.43167282
103DMPK0.42833788
104GRK70.42130526
105CDK150.41655698
106MAP2K10.41603811
107BCR0.41557272
108PLK30.41502057
109SIK10.40854279
110MST40.40135165
111BMX0.39756911
112CDK180.39670561
113YES10.38714111
114PRKACB0.38307205
115FER0.38063509
116CAMKK10.37991880
117FRK0.37443170
118BMPR20.37226018
119KSR10.37136797
120MAP3K20.36263518
121GRK60.35806639
122PRKCZ0.35260733
123CAMK2D0.35035093
124PRKDC0.35014901
125CDK11A0.34986467
126CDK190.34455586
127PAK30.34334413
128PRKCH0.34188726
129PDPK10.34186946
130IGF1R0.34180408
131IRAK30.33550059
132PRKCQ0.33034439
133CDC42BPA0.32498157
134CDK140.32355547
135PRKCB0.32093447
136DDR20.30738029
137PRKACG0.30028969
138MAPK100.29810241
139RPS6KA30.29683314

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009105.72908630
2Fatty acid biosynthesis_Homo sapiens_hsa000614.71898248
3Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.24053382
4Nicotine addiction_Homo sapiens_hsa050332.87190493
5Glutamatergic synapse_Homo sapiens_hsa047242.25096066
6Fatty acid metabolism_Homo sapiens_hsa012122.08343063
7Salivary secretion_Homo sapiens_hsa049702.02191125
8GABAergic synapse_Homo sapiens_hsa047271.94526445
9Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.69554136
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.68718461
11Fatty acid degradation_Homo sapiens_hsa000711.68037332
12Gastric acid secretion_Homo sapiens_hsa049711.64153796
13Steroid biosynthesis_Homo sapiens_hsa001001.57922980
14Morphine addiction_Homo sapiens_hsa050321.57736770
15Circadian entrainment_Homo sapiens_hsa047131.57600452
16Insulin secretion_Homo sapiens_hsa049111.56825164
17Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.52167061
18Long-term potentiation_Homo sapiens_hsa047201.49377046
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.42343126
20Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.42321325
21Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.40450871
22Calcium signaling pathway_Homo sapiens_hsa040201.40326229
23Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.37520980
24Circadian rhythm_Homo sapiens_hsa047101.37097545
25Olfactory transduction_Homo sapiens_hsa047401.33393419
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.32530726
27Synaptic vesicle cycle_Homo sapiens_hsa047211.31956888
28Aldosterone synthesis and secretion_Homo sapiens_hsa049251.29624787
29Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.28910152
30Bile secretion_Homo sapiens_hsa049761.22063097
31Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.18767643
32PPAR signaling pathway_Homo sapiens_hsa033201.15571154
33Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.12049086
34Cocaine addiction_Homo sapiens_hsa050301.10443748
35Sulfur metabolism_Homo sapiens_hsa009201.10084413
36Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.07708655
37Pancreatic secretion_Homo sapiens_hsa049721.03625177
38Arginine and proline metabolism_Homo sapiens_hsa003300.99848769
39Serotonergic synapse_Homo sapiens_hsa047260.99721772
40Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.99708439
41Renin secretion_Homo sapiens_hsa049240.99146135
42Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.99113180
43Taste transduction_Homo sapiens_hsa047420.99011579
44Dorso-ventral axis formation_Homo sapiens_hsa043200.98815015
45Prion diseases_Homo sapiens_hsa050200.98800072
46Amphetamine addiction_Homo sapiens_hsa050310.97246241
47Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.90663092
48Cholinergic synapse_Homo sapiens_hsa047250.89331142
49Melanogenesis_Homo sapiens_hsa049160.89316979
50Long-term depression_Homo sapiens_hsa047300.88525518
51Glioma_Homo sapiens_hsa052140.84470757
52Gap junction_Homo sapiens_hsa045400.83599190
53Butanoate metabolism_Homo sapiens_hsa006500.82338989
54cAMP signaling pathway_Homo sapiens_hsa040240.81827737
55Ether lipid metabolism_Homo sapiens_hsa005650.79469334
56Collecting duct acid secretion_Homo sapiens_hsa049660.79424143
57Propanoate metabolism_Homo sapiens_hsa006400.79303338
58Hippo signaling pathway_Homo sapiens_hsa043900.78239081
59Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.77477756
60Arginine biosynthesis_Homo sapiens_hsa002200.76965317
61Fatty acid elongation_Homo sapiens_hsa000620.76270657
62TGF-beta signaling pathway_Homo sapiens_hsa043500.75061887
63Dopaminergic synapse_Homo sapiens_hsa047280.72858176
64African trypanosomiasis_Homo sapiens_hsa051430.72665787
65Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.71320403
66Phospholipase D signaling pathway_Homo sapiens_hsa040720.71150811
67Thyroid hormone synthesis_Homo sapiens_hsa049180.70632682
68Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.70115737
69Carbohydrate digestion and absorption_Homo sapiens_hsa049730.69437203
70Cardiac muscle contraction_Homo sapiens_hsa042600.64593258
71GnRH signaling pathway_Homo sapiens_hsa049120.64371376
72Mineral absorption_Homo sapiens_hsa049780.63037486
73Histidine metabolism_Homo sapiens_hsa003400.61089643
74Oxytocin signaling pathway_Homo sapiens_hsa049210.60735715
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.60116009
76Axon guidance_Homo sapiens_hsa043600.59590141
77Alcoholism_Homo sapiens_hsa050340.59025929
78Hedgehog signaling pathway_Homo sapiens_hsa043400.57921232
79Oocyte meiosis_Homo sapiens_hsa041140.56562035
80Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.55538549
81Basal cell carcinoma_Homo sapiens_hsa052170.55150291
82cGMP-PKG signaling pathway_Homo sapiens_hsa040220.54365760
83Adipocytokine signaling pathway_Homo sapiens_hsa049200.53106336
84Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.52886970
85Vitamin B6 metabolism_Homo sapiens_hsa007500.51562105
86Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.51413924
87Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.51357117
88Glycerophospholipid metabolism_Homo sapiens_hsa005640.51187703
89Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.49356631
90Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.49141142
91Peroxisome_Homo sapiens_hsa041460.47713320
92Phototransduction_Homo sapiens_hsa047440.47658556
93Biosynthesis of amino acids_Homo sapiens_hsa012300.47425451
94MicroRNAs in cancer_Homo sapiens_hsa052060.46614129
95Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.45574590
96Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.45551125
97Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43665116
98Phosphatidylinositol signaling system_Homo sapiens_hsa040700.43364279
99Vascular smooth muscle contraction_Homo sapiens_hsa042700.43231002
100Choline metabolism in cancer_Homo sapiens_hsa052310.42788217
101Glucagon signaling pathway_Homo sapiens_hsa049220.42629441
102Wnt signaling pathway_Homo sapiens_hsa043100.41957882
103Dilated cardiomyopathy_Homo sapiens_hsa054140.41589791
104Lysine degradation_Homo sapiens_hsa003100.41562808
105Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.41065047
106MAPK signaling pathway_Homo sapiens_hsa040100.40907029
107ECM-receptor interaction_Homo sapiens_hsa045120.40750183
108Sphingolipid metabolism_Homo sapiens_hsa006000.39834850
109ABC transporters_Homo sapiens_hsa020100.39619613
1102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.38720492
111Ras signaling pathway_Homo sapiens_hsa040140.38268057
112Primary bile acid biosynthesis_Homo sapiens_hsa001200.37979431
113Tight junction_Homo sapiens_hsa045300.37663513
114Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.36226132
115Estrogen signaling pathway_Homo sapiens_hsa049150.35621640
116beta-Alanine metabolism_Homo sapiens_hsa004100.35493264
117Pentose phosphate pathway_Homo sapiens_hsa000300.34453714
118Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.34218340
119Alzheimers disease_Homo sapiens_hsa050100.34217638
120Thyroid hormone signaling pathway_Homo sapiens_hsa049190.33957076
121ErbB signaling pathway_Homo sapiens_hsa040120.33519598
122Sphingolipid signaling pathway_Homo sapiens_hsa040710.33416001
123Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.33139389
124Rap1 signaling pathway_Homo sapiens_hsa040150.33067064

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