DCAF11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a WD repeat-containing protein that interacts with the COP9 signalosome, a macromolecular complex that interacts with cullin-RING E3 ligases and regulates their activity by hydrolyzing cullin-Nedd8 conjugates. Multiple alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.08176926
2L-phenylalanine catabolic process (GO:0006559)7.08176926
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.73357141
4L-phenylalanine metabolic process (GO:0006558)6.73357141
5aromatic amino acid family catabolic process (GO:0009074)6.30300163
6tryptophan catabolic process (GO:0006569)5.65511055
7indole-containing compound catabolic process (GO:0042436)5.65511055
8indolalkylamine catabolic process (GO:0046218)5.65511055
9kynurenine metabolic process (GO:0070189)5.55465097
10triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.54801980
11bile acid biosynthetic process (GO:0006699)5.43718312
12glyoxylate metabolic process (GO:0046487)5.42582029
13alpha-linolenic acid metabolic process (GO:0036109)5.39552815
14tryptophan metabolic process (GO:0006568)5.34670515
15cysteine metabolic process (GO:0006534)5.11928759
16sulfur amino acid catabolic process (GO:0000098)5.05370813
17fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.98182654
18high-density lipoprotein particle remodeling (GO:0034375)4.90680506
19urea metabolic process (GO:0019627)4.85301963
20urea cycle (GO:0000050)4.85301963
21lysine catabolic process (GO:0006554)4.78806901
22lysine metabolic process (GO:0006553)4.78806901
23peptidyl-glutamic acid carboxylation (GO:0017187)4.72805141
24protein carboxylation (GO:0018214)4.72805141
25complement activation, alternative pathway (GO:0006957)4.64791316
26bile acid metabolic process (GO:0008206)4.61534454
27negative regulation of fibrinolysis (GO:0051918)4.61472933
28negative regulation of cell killing (GO:0031342)4.60445219
29negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.60445219
30cellular ketone body metabolic process (GO:0046950)4.54375072
31aromatic amino acid family metabolic process (GO:0009072)4.54320530
32regulation of protein activation cascade (GO:2000257)4.53485227
33homocysteine metabolic process (GO:0050667)4.49657860
34nitrogen cycle metabolic process (GO:0071941)4.49649634
35regulation of fibrinolysis (GO:0051917)4.45398080
36amino-acid betaine metabolic process (GO:0006577)4.45122636
37serine family amino acid catabolic process (GO:0009071)4.43282340
38regulation of triglyceride catabolic process (GO:0010896)4.41376957
39alpha-amino acid catabolic process (GO:1901606)4.32966122
40ethanol oxidation (GO:0006069)4.30978170
41reverse cholesterol transport (GO:0043691)4.30511253
42tyrosine metabolic process (GO:0006570)4.30418227
43regulation of cholesterol esterification (GO:0010872)4.27371414
44regulation of complement activation (GO:0030449)4.23772199
45protein-lipid complex assembly (GO:0065005)4.21023227
46macromolecular complex remodeling (GO:0034367)4.17766901
47plasma lipoprotein particle remodeling (GO:0034369)4.17766901
48protein-lipid complex remodeling (GO:0034368)4.17766901
49epoxygenase P450 pathway (GO:0019373)4.17696845
50triglyceride homeostasis (GO:0070328)4.14682529
51acylglycerol homeostasis (GO:0055090)4.14682529
52phospholipid efflux (GO:0033700)4.08071483
53cellular amino acid catabolic process (GO:0009063)4.06161042
54cellular glucuronidation (GO:0052695)4.04602633
55indolalkylamine metabolic process (GO:0006586)4.03354971
56coenzyme catabolic process (GO:0009109)4.01940640
57benzene-containing compound metabolic process (GO:0042537)4.01376687
58glutamate metabolic process (GO:0006536)3.98771065
59negative regulation of sterol transport (GO:0032372)3.98510101
60negative regulation of cholesterol transport (GO:0032375)3.98510101
61short-chain fatty acid metabolic process (GO:0046459)3.96954294
62cellular modified amino acid catabolic process (GO:0042219)3.95384531
63cellular biogenic amine catabolic process (GO:0042402)3.92148857
64amine catabolic process (GO:0009310)3.92148857
65ketone body metabolic process (GO:1902224)3.91383669
66bile acid and bile salt transport (GO:0015721)3.90297952
67plasma lipoprotein particle clearance (GO:0034381)3.87854194
68cholesterol efflux (GO:0033344)3.80009248
69fatty acid beta-oxidation (GO:0006635)3.79094419
70antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.78544529
71acetyl-CoA metabolic process (GO:0006084)3.76886502
722-oxoglutarate metabolic process (GO:0006103)3.75680865
73aspartate family amino acid catabolic process (GO:0009068)3.73413211
74fatty acid oxidation (GO:0019395)3.72144848
75uronic acid metabolic process (GO:0006063)3.71667000
76glucuronate metabolic process (GO:0019585)3.71667000
77carboxylic acid catabolic process (GO:0046395)3.71500453
78organic acid catabolic process (GO:0016054)3.71500453
79aldehyde catabolic process (GO:0046185)3.69682203
80drug catabolic process (GO:0042737)3.69127228
81monocarboxylic acid catabolic process (GO:0072329)3.68759920
82antigen processing and presentation of endogenous antigen (GO:0019883)3.67112041
83dicarboxylic acid biosynthetic process (GO:0043650)3.65994139
84imidazole-containing compound metabolic process (GO:0052803)3.65951269
85lipid oxidation (GO:0034440)3.65816129
86fatty acid catabolic process (GO:0009062)3.63873133
87serine family amino acid metabolic process (GO:0009069)3.60215200
88phospholipid homeostasis (GO:0055091)3.58588772
89drug transmembrane transport (GO:0006855)3.54289030
90regulation of bile acid biosynthetic process (GO:0070857)3.53776796
91plasma lipoprotein particle assembly (GO:0034377)3.53711263
92plasma lipoprotein particle organization (GO:0071827)3.53601725
93regulation of cholesterol homeostasis (GO:2000188)3.52981213
94antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.51543819
95glycine metabolic process (GO:0006544)3.51493741
96valine metabolic process (GO:0006573)3.51051462
97regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.49692523
98low-density lipoprotein particle remodeling (GO:0034374)3.48503587
99carnitine metabolic process (GO:0009437)3.47150555
100arginine metabolic process (GO:0006525)3.46921297
101negative regulation of lipase activity (GO:0060192)3.46545488
102response to nitrosative stress (GO:0051409)3.44541707
103positive regulation of triglyceride lipase activity (GO:0061365)3.41684783
104positive regulation of lipoprotein lipase activity (GO:0051006)3.41684783
105positive regulation of lipid catabolic process (GO:0050996)3.40753153
106protein-lipid complex subunit organization (GO:0071825)3.40221331
107cholesterol homeostasis (GO:0042632)3.39328302
108cofactor catabolic process (GO:0051187)3.38738812
109complement activation, classical pathway (GO:0006958)3.37025152
110very-low-density lipoprotein particle assembly (GO:0034379)3.36635671
111proline metabolic process (GO:0006560)3.36504881
112protoporphyrinogen IX metabolic process (GO:0046501)3.32637989
113NADH metabolic process (GO:0006734)3.29035291
114exogenous drug catabolic process (GO:0042738)3.27444295
115response to interleukin-15 (GO:0070672)3.19554078
116intestinal cholesterol absorption (GO:0030299)3.11894035
117regulation of apoptotic cell clearance (GO:2000425)3.07729659
118antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.02558098
119ethanol metabolic process (GO:0006067)3.00600228
120regulation of cholesterol metabolic process (GO:0090181)2.97103569
121cellular response to interleukin-15 (GO:0071350)2.97060361
122positive regulation of fatty acid biosynthetic process (GO:0045723)2.96022990
123proline biosynthetic process (GO:0006561)2.94044481
124hemoglobin metabolic process (GO:0020027)2.91102527
125regulation of humoral immune response (GO:0002920)2.89415503
126intestinal absorption (GO:0050892)2.89396428
127diacylglycerol metabolic process (GO:0046339)2.88905700
128negative regulation of lymphocyte mediated immunity (GO:0002707)2.87520756
129protoporphyrinogen IX biosynthetic process (GO:0006782)2.86327032
130oxaloacetate metabolic process (GO:0006107)2.86232623
131blood coagulation, intrinsic pathway (GO:0007597)2.85725569
132positive regulation of gamma-delta T cell activation (GO:0046645)2.85117299
133acute-phase response (GO:0006953)2.83825360
134regulation of cholesterol biosynthetic process (GO:0045540)2.77835538
135disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.77022411
136killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.77022411
137regulation of gamma-delta T cell differentiation (GO:0045586)2.73019212
138protein activation cascade (GO:0072376)2.68449560
139drug metabolic process (GO:0017144)2.68367203
140embryonic process involved in female pregnancy (GO:0060136)2.63197412
141lipoprotein metabolic process (GO:0042157)2.61662876
142angiotensin maturation (GO:0002003)2.61176231
143complement activation (GO:0006956)2.59594715
144fructose metabolic process (GO:0006000)2.57023256
145response to mercury ion (GO:0046689)2.55712675
146porphyrin-containing compound metabolic process (GO:0006778)2.55288296
147detection of bacterium (GO:0016045)2.54111755
148regulation of gamma-delta T cell activation (GO:0046643)2.52818045
149regulation of fatty acid biosynthetic process (GO:0042304)2.51907458
150fat-soluble vitamin biosynthetic process (GO:0042362)2.51904041
151negative regulation of leukocyte mediated immunity (GO:0002704)2.51669766
152negative regulation of erythrocyte differentiation (GO:0045647)2.50702311
153lipoprotein transport (GO:0042953)2.50585766
154porphyrin-containing compound biosynthetic process (GO:0006779)2.48373179
155glutamine family amino acid biosynthetic process (GO:0009084)2.48370604
156positive thymic T cell selection (GO:0045059)2.47108761
157omega-hydroxylase P450 pathway (GO:0097267)2.47063375
158positive regulation of blood coagulation (GO:0030194)2.46826776

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.42898720
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.43443206
3* LXR_22158963_ChIP-Seq_LIVER_Mouse5.85212866
4EGR1_23403033_ChIP-Seq_LIVER_Mouse5.80086922
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.90560584
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.82800533
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.36620893
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.73874608
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.34930605
10* MYC_22102868_ChIP-Seq_BL_Human2.28519851
11VDR_21846776_ChIP-Seq_THP-1_Human2.26332461
12TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.06570282
13ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.4578676
14BP1_19119308_ChIP-ChIP_Hs578T_Human1.96289158
15TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.95099732
16TCF7_22412390_ChIP-Seq_EML_Mouse1.94573657
17MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.94068776
18RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.90870200
19* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.88771964
20MAF_26560356_Chip-Seq_TH1_Human1.88676967
21E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.85163171
22KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.79390226
23* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.70974257
24GATA1_22025678_ChIP-Seq_K562_Human1.69114935
25KDM2B_26808549_Chip-Seq_SUP-B15_Human1.68593072
26* UTX_26944678_Chip-Seq_JUKART_Human1.67489220
27STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.66762757
28HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.65601168
29TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.65320832
30FOXA2_19822575_ChIP-Seq_HepG2_Human1.62595815
31CLOCK_20551151_ChIP-Seq_293T_Human1.61562104
32KDM2B_26808549_Chip-Seq_DND41_Human1.60044673
33VDR_24763502_ChIP-Seq_THP-1_Human1.57802381
34* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.57791701
35THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.56698744
36RUNX1_22412390_ChIP-Seq_EML_Mouse1.56482888
37P68_20966046_ChIP-Seq_HELA_Human1.53917087
38RACK7_27058665_Chip-Seq_MCF-7_Human1.50207762
39ELK3_25401928_ChIP-Seq_HUVEC_Human1.47463141
40* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.47200743
41BCL6_27268052_Chip-Seq_Bcells_Human1.47062230
42STAT4_19710469_ChIP-ChIP_TH1__Mouse1.46655147
43* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.45944702
44MAF_26560356_Chip-Seq_TH2_Human1.45120489
45SCL_19346495_ChIP-Seq_HPC-7_Human1.45103985
46* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.40545480
47RUNX_20019798_ChIP-Seq_JUKART_Human1.40237230
48STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.39202540
49HTT_18923047_ChIP-ChIP_STHdh_Human1.37112583
50IRF8_21731497_ChIP-ChIP_J774_Mouse1.36850371
51* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.36265962
52NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.36127252
53* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.36041509
54ELF1_20517297_ChIP-Seq_JURKAT_Human1.35160669
55SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.32937135
56VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.32766111
57LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.31417489
58MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.29577068
59SMC4_20622854_ChIP-Seq_HELA_Human1.29345063
60* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.27990377
61FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.27907559
62HNF4A_19822575_ChIP-Seq_HepG2_Human1.26488114
63SOX2_27498859_Chip-Seq_STOMACH_Mouse1.24457364
64* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.23331942
65SPI1_23127762_ChIP-Seq_K562_Human1.20971471
66PU.1_20513432_ChIP-Seq_Bcells_Mouse1.20958744
67MYB_26560356_Chip-Seq_TH2_Human1.19987055
68CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.19018111
69PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.18742090
70* MYB_26560356_Chip-Seq_TH1_Human1.18724410
71SA1_27219007_Chip-Seq_ERYTHROID_Human1.17083763
72IRF8_27001747_Chip-Seq_BMDM_Mouse1.16247365
73TET1_21451524_ChIP-Seq_MESCs_Mouse1.15831421
74PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15643996
75LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.14415900
76IRF8_22096565_ChIP-ChIP_GC-B_Human1.14109082
77TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.13805668
78ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.13480109
79CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.13467243
80* CREB1_26743006_Chip-Seq_LNCaP_Human1.13436816
81SPI1_23547873_ChIP-Seq_NB4_Human1.10007668
82GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09155068
83ETS1_21867929_ChIP-Seq_TH2_Mouse1.08528891
84MYB_21317192_ChIP-Seq_ERMYB_Mouse1.07987873
85PHF8_20622854_ChIP-Seq_HELA_Human1.04524533
86EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.04486151
87ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03305695
88NCOR1_26117541_ChIP-Seq_K562_Human1.02959859
89STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.00182398
90IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.99258475
91RXRA_24833708_ChIP-Seq_LIVER_Mouse0.98115392
92ESR2_21235772_ChIP-Seq_MCF-7_Human0.96450566
93ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.94124893
94RARG_19884340_ChIP-ChIP_MEFs_Mouse0.93141654
95ESR1_20079471_ChIP-ChIP_T-47D_Human0.92679374
96BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.92581826
97PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.91954667
98* GATA4_25053715_ChIP-Seq_YYC3_Human0.90649577
99AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.90471682
100NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.80367423
101NRF2_20460467_ChIP-Seq_MEFs_Mouse0.80367423
102* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.78848579
103TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.78162632
104Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.78014475
105BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.75795442
106AUTS2_25519132_ChIP-Seq_293T-REX_Human0.75297032
107SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.71934400
108LXR_22292898_ChIP-Seq_THP-1_Human0.69206044
109ZNF263_19887448_ChIP-Seq_K562_Human0.68944247
110EGR1_19032775_ChIP-ChIP_M12_Human0.68770756
111FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.67665647
112SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.67418508
113* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.67267101
114FOXA1_25552417_ChIP-Seq_VCAP_Human0.65721304
115TBX20_22328084_ChIP-Seq_HEART_Mouse0.65644445
116TBX20_22080862_ChIP-Seq_HEART_Mouse0.65644445
117CEBPB_22108803_ChIP-Seq_LS180_Human0.64347140
118GATA1_19941826_ChIP-Seq_K562_Human0.62817855
119RARA_24833708_ChIP-Seq_LIVER_Mouse0.62515092
120SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.62450298
121SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.61838690
122ESR1_21235772_ChIP-Seq_MCF-7_Human0.61450565
123PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.60388128
124CBP_21632823_ChIP-Seq_H3396_Human0.59240848
125NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.59163621
126GATA1_19941827_ChIP-Seq_MEL_Mouse0.58616912
127RARB_24833708_ChIP-Seq_LIVER_Mouse0.57900503
128RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.57850124
129FOXO3_23340844_ChIP-Seq_DLD1_Human0.57436446
130PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.57326055
131BCAT_22108803_ChIP-Seq_LS180_Human0.57142659
132GATA2_19941826_ChIP-Seq_K562_Human0.56492952
133MYC_19915707_ChIP-ChIP_AK7_Human0.56398122
134* AR_20517297_ChIP-Seq_VCAP_Human0.56311508
135CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.55502379
136SOX2_20726797_ChIP-Seq_SW620_Human0.54768245
137TAF15_26573619_Chip-Seq_HEK293_Human0.54228347
138OCT4_20526341_ChIP-Seq_ESCs_Human0.53984085
139CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.53708958
140KAP1_22055183_ChIP-Seq_ESCs_Mouse0.52747648
141ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.52676665
142ERG_21242973_ChIP-ChIP_JURKAT_Human0.52462695
143ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.52026772
144NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.51875344
145P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.51354263
146P53_21459846_ChIP-Seq_SAOS-2_Human0.51208545
147TAF2_19829295_ChIP-Seq_ESCs_Human0.50920781
148* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.50178924
149SALL4_18804426_ChIP-ChIP_XEN_Mouse0.49616386
150PPAR_26484153_Chip-Seq_NCI-H1993_Human0.48437385
151GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.46877800
152* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.46592424
153CDX2_20551321_ChIP-Seq_CACO-2_Human0.46537518
154GATA6_25053715_ChIP-Seq_YYC3_Human0.46482130
155SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.46478622
156DNAJC2_21179169_ChIP-ChIP_NT2_Human0.46459193
157ESET_19884257_ChIP-Seq_ESCs_Mouse0.46221131
158ERG_20517297_ChIP-Seq_VCAP_Human0.46177686
159CTCF_27219007_Chip-Seq_Bcells_Human0.46084569
160BCOR_27268052_Chip-Seq_Bcells_Human0.46037629
161FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.45197824
162STAT1_17558387_ChIP-Seq_HELA_Human0.45115291
163PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.44624572

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.79416327
2MP0005360_urolithiasis6.96869503
3MP0005085_abnormal_gallbladder_physiolo5.88860431
4MP0005365_abnormal_bile_salt5.88784132
5MP0008875_abnormal_xenobiotic_pharmacok5.07410640
6MP0003806_abnormal_nucleotide_metabolis3.81645486
7MP0003252_abnormal_bile_duct3.62517639
8MP0010329_abnormal_lipoprotein_level3.35754156
9MP0003195_calcinosis3.09862707
10MP0005083_abnormal_biliary_tract3.08379440
11MP0009840_abnormal_foam_cell3.07965285
12MP0005332_abnormal_amino_acid2.81954769
13MP0001666_abnormal_nutrient_absorption2.72713520
14MP0003191_abnormal_cellular_cholesterol2.22971656
15MP0002138_abnormal_hepatobiliary_system2.22302645
16MP0003172_abnormal_lysosome_physiology2.19501662
17MP0002118_abnormal_lipid_homeostasis2.14179734
18MP0004019_abnormal_vitamin_homeostasis2.12321488
19MP0000609_abnormal_liver_physiology2.02239448
20MP0008260_abnormal_autophagy2.01157492
21MP0003303_peritoneal_inflammation1.99673910
22MP0000685_abnormal_immune_system1.96748977
23MP0003183_abnormal_peptide_metabolism1.93182589
24MP0001835_abnormal_antigen_presentation1.88097958
25MP0005025_abnormal_response_to1.80924684
26MP0005319_abnormal_enzyme/_coenzyme1.79835685
27MP0005671_abnormal_response_to1.79617477
28MP0003868_abnormal_feces_composition1.67679860
29MP0005584_abnormal_enzyme/coenzyme_acti1.66440852
30MP0010155_abnormal_intestine_physiology1.62134275
31MP0001764_abnormal_homeostasis1.59119534
32MP0009785_altered_susceptibility_to1.56316713
33MP0002419_abnormal_innate_immunity1.55843635
34MP0005000_abnormal_immune_tolerance1.54131864
35MP0005387_immune_system_phenotype1.52849556
36MP0001790_abnormal_immune_system1.52849556
37MP0001800_abnormal_humoral_immune1.52407474
38MP0009643_abnormal_urine_homeostasis1.51053072
39MP0003866_abnormal_defecation1.51018882
40MP0003763_abnormal_thymus_physiology1.44211961
41MP0005451_abnormal_body_composition1.44058796
42MP0002837_dystrophic_cardiac_calcinosis1.43640865
43MP0002132_abnormal_respiratory_system1.41285360
44MP0002723_abnormal_immune_serum1.35655347
45MP0003656_abnormal_erythrocyte_physiolo1.33137059
46MP0003879_abnormal_hair_cell1.33053758
47MP0004947_skin_inflammation1.31235750
48MP0003011_delayed_dark_adaptation1.30578798
49MP0009333_abnormal_splenocyte_physiolog1.29656191
50MP0002166_altered_tumor_susceptibility1.29224955
51MP0002420_abnormal_adaptive_immunity1.28093453
52MP0001819_abnormal_immune_cell1.27925034
53MP0003186_abnormal_redox_activity1.24998499
54MP0004043_abnormal_pH_regulation1.19797254
55MP0005636_abnormal_mineral_homeostasis1.17462882
56MP0002398_abnormal_bone_marrow1.17196064
57MP0002452_abnormal_antigen_presenting1.17144745
58MP0006036_abnormal_mitochondrial_physio1.16592954
59MP0000604_amyloidosis1.13556498
60MP0000689_abnormal_spleen_morphology1.12961561
61MP0002722_abnormal_immune_system1.11213671
62MP0009697_abnormal_copulation1.09783652
63MP0001533_abnormal_skeleton_physiology1.09722912
64MP0004130_abnormal_muscle_cell1.08043362
65MP0000716_abnormal_immune_system1.07494273
66MP0000465_gastrointestinal_hemorrhage1.05675757
67MP0004858_abnormal_nervous_system1.04584789
68MP0002148_abnormal_hypersensitivity_rea1.03523673
69MP0002405_respiratory_system_inflammati1.03248691
70MP0009764_decreased_sensitivity_to1.02943179
71MP0000598_abnormal_liver_morphology1.00057264
72MP0002078_abnormal_glucose_homeostasis0.99937414
73MP0005670_abnormal_white_adipose0.99765211
74MP0002876_abnormal_thyroid_physiology0.99524175
75MP0005377_hearing/vestibular/ear_phenot0.99204982
76MP0003878_abnormal_ear_physiology0.99204982
77MP0002254_reproductive_system_inflammat0.96692686
78MP0002429_abnormal_blood_cell0.95717182
79MP0001873_stomach_inflammation0.94964727
80MP0005647_abnormal_sex_gland0.93527128
81MP0005535_abnormal_body_temperature0.92357393
82MP0009642_abnormal_blood_homeostasis0.90080112
83MP0001756_abnormal_urination0.89467236
84MP0009763_increased_sensitivity_to0.89427138
85MP0003329_amyloid_beta_deposits0.87658199
86MP0005220_abnormal_exocrine_pancreas0.87256440
87MP0008469_abnormal_protein_level0.86969683
88MP0002971_abnormal_brown_adipose0.84582637
89MP0002822_catalepsy0.83553050
90MP0002396_abnormal_hematopoietic_system0.83410002
91MP0000703_abnormal_thymus_morphology0.83284098
92MP0005084_abnormal_gallbladder_morpholo0.80754333
93MP0000858_altered_metastatic_potential0.79877442
94MP0003690_abnormal_glial_cell0.79023547
95MP0001545_abnormal_hematopoietic_system0.77080755
96MP0005397_hematopoietic_system_phenotyp0.77080755
97MP0010368_abnormal_lymphatic_system0.77021033
98MP0005408_hypopigmentation0.74097701
99MP0000747_muscle_weakness0.73983543
100MP0005409_darkened_coat_color0.73674320
101MP0002089_abnormal_postnatal_growth/wei0.72952416
102MP0009765_abnormal_xenobiotic_induced0.72666640
103MP0005376_homeostasis/metabolism_phenot0.72429881
104MP0003122_maternal_imprinting0.71869824
105MP0005334_abnormal_fat_pad0.70746613
106MP0006035_abnormal_mitochondrial_morpho0.69911288
107MP0001661_extended_life_span0.66627133
108MP0005076_abnormal_cell_differentiation0.66310116
109MP0005266_abnormal_metabolism0.65728736
110MP0005448_abnormal_energy_balance0.65131311
111MP0004782_abnormal_surfactant_physiolog0.64323238
112MP0005058_abnormal_lysosome_morphology0.63196299
113MP0001765_abnormal_ion_homeostasis0.62562730
114MP0002136_abnormal_kidney_physiology0.59557548
115MP0000230_abnormal_systemic_arterial0.59364362
116MP0005666_abnormal_adipose_tissue0.57995235
117MP0002928_abnormal_bile_duct0.55174014
118MP0003953_abnormal_hormone_level0.54769209
119MP0003075_altered_response_to0.51561204
120MP0000639_abnormal_adrenal_gland0.50867738
121MP0003705_abnormal_hypodermis_morpholog0.50247730
122MP0002090_abnormal_vision0.48009714
123MP0003724_increased_susceptibility_to0.47278820
124MP0008872_abnormal_physiological_respon0.46751262
125MP0002269_muscular_atrophy0.46708265
126MP0008874_decreased_physiological_sensi0.46387231
127MP0003638_abnormal_response/metabolism_0.46010860
128MP0005330_cardiomyopathy0.45751796
129MP0004147_increased_porphyrin_level0.45687502
130MP0004036_abnormal_muscle_relaxation0.42638898
131MP0001944_abnormal_pancreas_morphology0.42419236
132MP0005464_abnormal_platelet_physiology0.39323272
133MP0003646_muscle_fatigue0.39287354
134MP0005166_decreased_susceptibility_to0.38398559
135MP0003300_gastrointestinal_ulcer0.37805727
136MP0002909_abnormal_adrenal_gland0.35372962
137MP0003959_abnormal_lean_body0.34678849
138MP0008961_abnormal_basal_metabolism0.34410883
139MP0001984_abnormal_olfaction0.34138323
140MP0002693_abnormal_pancreas_physiology0.33837515
141MP0008873_increased_physiological_sensi0.33328517
142MP0002168_other_aberrant_phenotype0.32563411
143MP0005395_other_phenotype0.32184911
144MP0003436_decreased_susceptibility_to0.31129667
145MP0001845_abnormal_inflammatory_respons0.30255096
146MP0000579_abnormal_nail_morphology0.30243120
147MP0004264_abnormal_extraembryonic_tissu0.29964695
148MP0009384_cardiac_valve_regurgitation0.29783763
149MP0006082_CNS_inflammation0.28921652

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.74729751
2Intrahepatic cholestasis (HP:0001406)6.40380005
3Deep venous thrombosis (HP:0002625)6.17331098
4Abnormality of monocarboxylic acid metabolism (HP:0010996)5.59900526
5Prolonged partial thromboplastin time (HP:0003645)5.57844085
6Xanthomatosis (HP:0000991)5.54601885
7Hypobetalipoproteinemia (HP:0003563)5.36815518
8Hyperlipoproteinemia (HP:0010980)4.90427878
9Ketosis (HP:0001946)4.60199863
10Complement deficiency (HP:0004431)4.55845067
11Hyperammonemia (HP:0001987)4.47165190
12Hypoglycemic coma (HP:0001325)4.30913475
13Hyperglycinemia (HP:0002154)4.13990715
14Hypolipoproteinemia (HP:0010981)4.11891183
15Hyperglycinuria (HP:0003108)4.05383519
16Joint hemorrhage (HP:0005261)4.02150087
17Abnormality of the common coagulation pathway (HP:0010990)3.96225938
18Abnormality of fatty-acid metabolism (HP:0004359)3.95270331
19Abnormality of serine family amino acid metabolism (HP:0010894)3.92575390
20Abnormality of glycine metabolism (HP:0010895)3.92575390
21Epidermoid cyst (HP:0200040)3.89491821
22Ketoacidosis (HP:0001993)3.89369048
23Abnormality of glutamine family amino acid metabolism (HP:0010902)3.84757597
24Poikilocytosis (HP:0004447)3.80474465
25Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.77589937
26Fat malabsorption (HP:0002630)3.77506170
27Abnormality of sulfur amino acid metabolism (HP:0004339)3.77306758
28Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.76476790
29Abnormality of aspartate family amino acid metabolism (HP:0010899)3.69423983
30Hypoalphalipoproteinemia (HP:0003233)3.67987734
31Abnormality of methionine metabolism (HP:0010901)3.57602242
32Conjugated hyperbilirubinemia (HP:0002908)3.55618883
33Eczematoid dermatitis (HP:0000976)3.46055998
34Hemorrhage of the eye (HP:0011885)3.45405971
35Abnormality of the intrinsic pathway (HP:0010989)3.43201625
36Reticulocytosis (HP:0001923)3.28207264
37Gout (HP:0001997)3.25470603
38Abnormality of complement system (HP:0005339)3.14997473
39Hyperbilirubinemia (HP:0002904)3.13551165
40Myositis (HP:0100614)3.11465720
41Hypercholesterolemia (HP:0003124)3.09593787
42Abnormality of the heme biosynthetic pathway (HP:0010472)3.08616153
43Metabolic acidosis (HP:0001942)3.00032578
44Gastrointestinal infarctions (HP:0005244)2.99663099
45Abnormality of purine metabolism (HP:0004352)2.95719680
46Abnormality of dicarboxylic acid metabolism (HP:0010995)2.92697830
47Dicarboxylic aciduria (HP:0003215)2.92697830
48Abnormality of nucleobase metabolism (HP:0010932)2.90721851
49Orchitis (HP:0100796)2.89912825
50Hypochromic anemia (HP:0001931)2.89756457
51Steatorrhea (HP:0002570)2.87510635
52Retrobulbar optic neuritis (HP:0100654)2.81708455
53Optic neuritis (HP:0100653)2.81708455
54Delayed CNS myelination (HP:0002188)2.81344791
55Abnormality of pyrimidine metabolism (HP:0004353)2.80726192
56Abnormality of serum amino acid levels (HP:0003112)2.79153416
57Hypoglycemic seizures (HP:0002173)2.77659618
58Lethargy (HP:0001254)2.72638838
59Generalized aminoaciduria (HP:0002909)2.71343768
60Cerebral edema (HP:0002181)2.65274057
61Abnormal gallbladder morphology (HP:0012437)2.63275888
62Increased serum ferritin (HP:0003281)2.62554674
63Skin nodule (HP:0200036)2.60653986
64Hepatocellular carcinoma (HP:0001402)2.57686542
65Purpura (HP:0000979)2.55685734
66Vascular calcification (HP:0004934)2.55223468
67Cholelithiasis (HP:0001081)2.52357778
68Pulmonary embolism (HP:0002204)2.52028734
69Abnormality of iron homeostasis (HP:0011031)2.50900251
70Late onset (HP:0003584)2.50830834
71Hyperinsulinemic hypoglycemia (HP:0000825)2.46841653
72Spontaneous abortion (HP:0005268)2.42492111
73Systemic lupus erythematosus (HP:0002725)2.41481778
74Myocardial infarction (HP:0001658)2.41397705
75Exercise-induced myalgia (HP:0003738)2.33911809
76Vomiting (HP:0002013)2.33881555
77Abnormality of transition element cation homeostasis (HP:0011030)2.32174740
78Abnormality of macrophages (HP:0004311)2.30456362
79Myoglobinuria (HP:0002913)2.30379856
80Brushfield spots (HP:0001088)2.28696201
81Irritability (HP:0000737)2.27745028
82Meningitis (HP:0001287)2.26453109
83Joint swelling (HP:0001386)2.24978972
84Recurrent abscess formation (HP:0002722)2.23426326
85Cholecystitis (HP:0001082)2.22495556
86Abnormal gallbladder physiology (HP:0012438)2.22495556
87Mitral stenosis (HP:0001718)2.20694824
88Renal cortical cysts (HP:0000803)2.19696353
89Nephritis (HP:0000123)2.19665450
90Pancreatitis (HP:0001733)2.19450609
91Cardiovascular calcification (HP:0011915)2.19125074
92Alkalosis (HP:0001948)2.17289681
93Polycythemia (HP:0001901)2.17150424
94Vasculitis (HP:0002633)2.16924392
95Malnutrition (HP:0004395)2.16769055
96Neonatal onset (HP:0003623)2.16250962
97Acanthocytosis (HP:0001927)2.15972798
98Cerebral palsy (HP:0100021)2.15946673
99Epistaxis (HP:0000421)2.15820935
100Colitis (HP:0002583)2.15275450
101Proximal tubulopathy (HP:0000114)2.14923239
102Sensorimotor neuropathy (HP:0007141)2.14712651
103Encephalitis (HP:0002383)2.13913803
104Myopathic facies (HP:0002058)2.12276464
105Prolonged bleeding time (HP:0003010)2.12154516
106Increased purine levels (HP:0004368)2.10050823
107Hyperuricemia (HP:0002149)2.10050823
108Abnormality of the gallbladder (HP:0005264)2.09150731
109Recurrent gram-negative bacterial infections (HP:0005420)2.09138457
110Hypochromic microcytic anemia (HP:0004840)2.08641434
111Gastrointestinal inflammation (HP:0004386)2.07988322
112Mediastinal lymphadenopathy (HP:0100721)2.07840469
113Amyloidosis (HP:0011034)2.07415463
114Pustule (HP:0200039)2.07224169
115Arterial thrombosis (HP:0004420)2.07129391
116Abnormality of mucopolysaccharide metabolism (HP:0011020)2.06218236
117Abnormality of polysaccharide metabolism (HP:0011012)2.06218236
118Abnormality of glycosaminoglycan metabolism (HP:0004371)2.06218236
119Glycosuria (HP:0003076)2.05857431
120Abnormality of urine glucose concentration (HP:0011016)2.05857431
121Spastic diplegia (HP:0001264)2.05684521
122Centrally nucleated skeletal muscle fibers (HP:0003687)2.04955271
123Enlarged kidneys (HP:0000105)2.04456428
124Rhabdomyolysis (HP:0003201)2.04135520
125Mucopolysacchariduria (HP:0008155)2.03026764
126Urinary glycosaminoglycan excretion (HP:0003541)2.03026764
127Opisthotonus (HP:0002179)1.99912828
128Keratoconjunctivitis sicca (HP:0001097)1.99195199
129Hyperglycemia (HP:0003074)1.98769033
130Gingivitis (HP:0000230)1.98742860
131Inflammation of the large intestine (HP:0002037)1.98311866
132Chronic obstructive pulmonary disease (HP:0006510)1.97099102
133Obstructive lung disease (HP:0006536)1.97099102
134Flat acetabular roof (HP:0003180)1.97052061
135Esophageal varix (HP:0002040)1.95258633
136Glomerulonephritis (HP:0000099)1.95025997
137Symptomatic seizures (HP:0011145)1.92770822
138Recurrent bacterial skin infections (HP:0005406)1.92249425
139Hydroxyprolinuria (HP:0003080)1.91412484
140Abnormality of proline metabolism (HP:0010907)1.91412484
141Microcytic anemia (HP:0001935)1.89817255
142Gangrene (HP:0100758)1.89455018
143Anorexia (HP:0002039)1.86312098
144Menorrhagia (HP:0000132)1.86263644
145Acute hepatic failure (HP:0006554)1.86232325
146Pulmonary infiltrates (HP:0002113)1.86115320
147Gingival bleeding (HP:0000225)1.85138600
148Dysostosis multiplex (HP:0000943)1.84260261
149Hypophosphatemia (HP:0002148)1.83455879
150Recurrent fungal infections (HP:0002841)1.83180540
151Keratoconjunctivitis (HP:0001096)1.81747018
152Abnormal cartilage morphology (HP:0002763)1.81687459
153Abnormal delayed hypersensitivity skin test (HP:0002963)1.80648651
154Abnormality of reticulocytes (HP:0004312)1.80491339
155Rickets (HP:0002748)1.79765992
156Cellulitis (HP:0100658)1.78906777
157Elevated hepatic transaminases (HP:0002910)1.77749919
158Hepatic necrosis (HP:0002605)1.77590058
159Abnormal enzyme/coenzyme activity (HP:0012379)1.76444347
160Thrombophlebitis (HP:0004418)1.75689593

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.45077977
2ERN13.87898707
3FGFR43.70798134
4SIK13.67829784
5INSRR3.32268054
6PRPF4B2.78226428
7TAOK32.64293451
8RIPK42.13651319
9TESK22.13566913
10PINK11.88831343
11ICK1.87784819
12TRIB31.84571464
13EEF2K1.82704694
14PIK3CG1.73882475
15ERBB41.72755856
16TYK21.69352042
17MAP2K41.67271498
18EPHB11.60248107
19MAP3K71.58534019
20SMG11.55245171
21FES1.51061765
22MST1R1.49071503
23MAPK151.47648699
24PKN21.47400612
25SIK21.44521564
26FLT31.44349494
27MAPK111.40549525
28WNK41.36857127
29DAPK21.36111178
30OBSCN1.34563929
31FGFR21.29256658
32TAOK11.27981111
33PTK61.27689276
34CDK121.27689136
35EPHA31.23782755
36JAK11.21246399
37FRK1.20969636
38PHKG21.14864095
39PHKG11.14864095
40MAPKAPK31.14677755
41CSF1R1.14248981
42RIPK11.13722888
43LMTK21.13324996
44TNK21.13038803
45JAK21.12021979
46IRAK41.11622498
47TXK1.10620649
48SCYL21.09711145
49BTK1.09090646
50SYK1.08509807
51PRKAA21.07140289
52MYLK1.04510862
53MAP2K31.03862092
54NEK90.97423079
55MAP3K30.95054468
56TBK10.93924124
57BLK0.93656738
58MAP3K140.93358954
59MAP3K130.90225351
60TIE10.89085812
61JAK30.88422085
62HCK0.84539117
63MARK20.84377860
64OXSR10.84328021
65SIK30.83717787
66MAP2K60.83441966
67MATK0.83164181
68IKBKB0.79844747
69MAPK120.78611212
70PRKAA10.78387660
71CAMK2G0.78082692
72SGK30.76611691
73PDK40.76313188
74PDK30.76313188
75GRK60.75949017
76ABL20.74854189
77TTN0.73970636
78SGK2230.73427236
79SGK4940.73427236
80CDK40.73418847
81STK38L0.73296916
82LCK0.72843448
83RPS6KA20.72592874
84MAP3K110.72380515
85FGR0.72299723
86WNK30.70764261
87PAK30.70733479
88EPHA40.70061892
89IRAK30.69076952
90PRKCZ0.68758851
91CDK60.68589479
92ERBB20.67451745
93MAP3K20.67412450
94MAP3K100.67377564
95CAMKK10.67057136
96KDR0.66863498
97LATS10.66852448
98PRKACG0.66344213
99MAP3K10.66249775
100LYN0.66144295
101HIPK20.65619522
102PRKCQ0.65546404
103RPS6KL10.63841885
104RPS6KC10.63841885
105MET0.62890897
106IKBKE0.62438252
107PDPK10.61800175
108SGK20.60233981
109NEK60.59116292
110MAP2K10.58560303
111CSK0.58416788
112PIM10.57632984
113CDC42BPA0.56825662
114MAPKAPK20.56773939
115DYRK1B0.56258430
116CAMK1D0.56020887
117PKN10.55289756
118BMPR20.55279379
119STK390.54278536
120MAPK40.54044023
121GSK3A0.52537971
122PTK20.50700013
123BMX0.49791920
124PBK0.49544157
125MUSK0.49174639
126FYN0.48966730
127MAP4K10.48623507
128TAOK20.47207021
129RPS6KA60.46796751
130MAPK70.46767947
131GRK10.46487231
132CHUK0.46108271
133LRRK20.45748266
134RPS6KB10.44364442
135PRKCH0.43072231
136FGFR30.42387902
137MAP2K20.42138788
138ARAF0.42112145
139PDK10.40231756
140MAP3K50.40157250
141TGFBR20.39839624
142PRKD10.39826702
143RET0.39453808
144PIK3CA0.39163760
145ITK0.37737828
146PDK20.35569530
147KSR20.34013019
148CAMK40.32914222
149ZAP700.32913146

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.05587264
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.28296598
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.23943299
4Nitrogen metabolism_Homo sapiens_hsa009103.06979691
5Fatty acid degradation_Homo sapiens_hsa000712.75209146
6Arginine biosynthesis_Homo sapiens_hsa002202.71217128
7Tryptophan metabolism_Homo sapiens_hsa003802.68520200
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.67510617
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.55324285
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.55027284
11Butanoate metabolism_Homo sapiens_hsa006502.41236517
12Complement and coagulation cascades_Homo sapiens_hsa046102.29615040
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.27453714
14Propanoate metabolism_Homo sapiens_hsa006402.27244556
15Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.23229995
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.15716135
17Peroxisome_Homo sapiens_hsa041462.13596044
18Fatty acid metabolism_Homo sapiens_hsa012122.01362388
19Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.87411012
20Histidine metabolism_Homo sapiens_hsa003401.86875576
21Chemical carcinogenesis_Homo sapiens_hsa052041.86176388
22PPAR signaling pathway_Homo sapiens_hsa033201.84213248
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.83734440
242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.80549387
25beta-Alanine metabolism_Homo sapiens_hsa004101.76209759
26Steroid hormone biosynthesis_Homo sapiens_hsa001401.72203033
27Sulfur metabolism_Homo sapiens_hsa009201.68956152
28Retinol metabolism_Homo sapiens_hsa008301.59429994
29Pyruvate metabolism_Homo sapiens_hsa006201.55396488
30Phenylalanine metabolism_Homo sapiens_hsa003601.55216864
31Caffeine metabolism_Homo sapiens_hsa002321.54011200
32Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.53177351
33Fatty acid elongation_Homo sapiens_hsa000621.53034822
34Drug metabolism - other enzymes_Homo sapiens_hsa009831.51983584
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.45683470
36Bile secretion_Homo sapiens_hsa049761.43094875
37Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.42271594
38Tyrosine metabolism_Homo sapiens_hsa003501.42228658
39Staphylococcus aureus infection_Homo sapiens_hsa051501.41515734
40Selenocompound metabolism_Homo sapiens_hsa004501.40108783
41Starch and sucrose metabolism_Homo sapiens_hsa005001.39448873
42Maturity onset diabetes of the young_Homo sapiens_hsa049501.36686200
43ABC transporters_Homo sapiens_hsa020101.30871165
44Carbon metabolism_Homo sapiens_hsa012001.23918995
45Renin-angiotensin system_Homo sapiens_hsa046141.23750262
46Fat digestion and absorption_Homo sapiens_hsa049751.20833605
47Cysteine and methionine metabolism_Homo sapiens_hsa002701.17622293
48Folate biosynthesis_Homo sapiens_hsa007901.13301721
49Biosynthesis of amino acids_Homo sapiens_hsa012301.11414693
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.11088535
51Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.09910187
52Steroid biosynthesis_Homo sapiens_hsa001001.08081822
53Acute myeloid leukemia_Homo sapiens_hsa052211.04452362
54B cell receptor signaling pathway_Homo sapiens_hsa046621.02719714
55Arginine and proline metabolism_Homo sapiens_hsa003301.00455178
56Primary immunodeficiency_Homo sapiens_hsa053400.99397720
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.97953214
58Cyanoamino acid metabolism_Homo sapiens_hsa004600.91969701
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.90763453
60Leishmaniasis_Homo sapiens_hsa051400.90704714
61Non-small cell lung cancer_Homo sapiens_hsa052230.88607459
62Sulfur relay system_Homo sapiens_hsa041220.88487786
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.83785017
64Vitamin digestion and absorption_Homo sapiens_hsa049770.83478319
65Glycerolipid metabolism_Homo sapiens_hsa005610.79639797
66Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.79294981
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.78937176
68Osteoclast differentiation_Homo sapiens_hsa043800.78900603
69Lysine degradation_Homo sapiens_hsa003100.77677546
70Vitamin B6 metabolism_Homo sapiens_hsa007500.71509325
71Glutathione metabolism_Homo sapiens_hsa004800.70774371
72Graft-versus-host disease_Homo sapiens_hsa053320.68658757
73Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.67465178
74T cell receptor signaling pathway_Homo sapiens_hsa046600.66045411
75Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.65283591
76Pertussis_Homo sapiens_hsa051330.64638253
77NF-kappa B signaling pathway_Homo sapiens_hsa040640.59863167
78Fatty acid biosynthesis_Homo sapiens_hsa000610.56424503
79Allograft rejection_Homo sapiens_hsa053300.55906151
80Autoimmune thyroid disease_Homo sapiens_hsa053200.54812473
81Pentose phosphate pathway_Homo sapiens_hsa000300.51005567
82Toll-like receptor signaling pathway_Homo sapiens_hsa046200.50872164
83Tuberculosis_Homo sapiens_hsa051520.49542834
84Jak-STAT signaling pathway_Homo sapiens_hsa046300.48418046
85Metabolic pathways_Homo sapiens_hsa011000.48322120
86Herpes simplex infection_Homo sapiens_hsa051680.48308454
87Prolactin signaling pathway_Homo sapiens_hsa049170.44652761
88Chronic myeloid leukemia_Homo sapiens_hsa052200.43702848
89Hematopoietic cell lineage_Homo sapiens_hsa046400.43416229
90Influenza A_Homo sapiens_hsa051640.39396998
91Insulin resistance_Homo sapiens_hsa049310.37840046
92Antigen processing and presentation_Homo sapiens_hsa046120.37471861
93Fructose and mannose metabolism_Homo sapiens_hsa000510.37451814
94Galactose metabolism_Homo sapiens_hsa000520.37355731
95RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.37351832
96VEGF signaling pathway_Homo sapiens_hsa043700.37303311
97mTOR signaling pathway_Homo sapiens_hsa041500.37123067
98Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.36781604
99Measles_Homo sapiens_hsa051620.36680007
100Intestinal immune network for IgA production_Homo sapiens_hsa046720.34977693
101Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.34263752
102Adipocytokine signaling pathway_Homo sapiens_hsa049200.33430654
103Phosphatidylinositol signaling system_Homo sapiens_hsa040700.31857512
104TNF signaling pathway_Homo sapiens_hsa046680.31347766
105alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.29923875
106Prion diseases_Homo sapiens_hsa050200.29591850
107Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.27062608
108One carbon pool by folate_Homo sapiens_hsa006700.23695412
109Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.21262524
110Linoleic acid metabolism_Homo sapiens_hsa005910.19909749
111Glycerophospholipid metabolism_Homo sapiens_hsa005640.19751509
112Glucagon signaling pathway_Homo sapiens_hsa049220.17875835
113AMPK signaling pathway_Homo sapiens_hsa041520.07385926
114Regulation of autophagy_Homo sapiens_hsa041400.01377255
115Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1611865
116Hepatitis C_Homo sapiens_hsa05160-0.1416622
117Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1158488
118Protein export_Homo sapiens_hsa03060-0.1128989
119Other glycan degradation_Homo sapiens_hsa00511-0.1111573
120Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1083522
121Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1031378
122Mineral absorption_Homo sapiens_hsa04978-0.1008398
123Parkinsons disease_Homo sapiens_hsa05012-0.1002458
124Type II diabetes mellitus_Homo sapiens_hsa04930-0.0893367
125Circadian rhythm_Homo sapiens_hsa04710-0.0810703
126Alzheimers disease_Homo sapiens_hsa05010-0.0789460
127Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0741717
128Lysosome_Homo sapiens_hsa04142-0.0696107
129Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.0639622
130Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.0553415
131Insulin signaling pathway_Homo sapiens_hsa04910-0.0216576
132Oxidative phosphorylation_Homo sapiens_hsa00190-0.0144104
133Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0081032

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