DCAF12L1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA methylation involved in gamete generation (GO:0043046)8.29476589
2synapsis (GO:0007129)7.70411978
3chromosome organization involved in meiosis (GO:0070192)6.63189101
4meiotic chromosome segregation (GO:0045132)6.43478718
5gonadal mesoderm development (GO:0007506)6.25446141
6synaptonemal complex assembly (GO:0007130)6.17062380
7male meiosis I (GO:0007141)6.04511805
8regulation of short-term neuronal synaptic plasticity (GO:0048172)5.84266372
9resolution of meiotic recombination intermediates (GO:0000712)5.67164755
10male meiosis (GO:0007140)5.63901581
11synaptonemal complex organization (GO:0070193)5.53322541
12vocalization behavior (GO:0071625)5.29128846
13neuron cell-cell adhesion (GO:0007158)5.26210842
14positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.22330552
15synaptic vesicle exocytosis (GO:0016079)5.22180076
16regulation of meiosis I (GO:0060631)5.14034957
17regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.89253215
18meiosis I (GO:0007127)4.83863488
19meiotic nuclear division (GO:0007126)4.81999242
20gene silencing by RNA (GO:0031047)4.76837121
21DNA synthesis involved in DNA repair (GO:0000731)4.75915051
22positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.74567754
23glutamate secretion (GO:0014047)4.65226306
24regulation of glutamate receptor signaling pathway (GO:1900449)4.62767925
25regulation of synaptic vesicle exocytosis (GO:2000300)4.60804954
26locomotory exploration behavior (GO:0035641)4.55480648
27protein localization to synapse (GO:0035418)4.54915071
28positive regulation of meiosis (GO:0045836)4.53128890
29synaptic vesicle maturation (GO:0016188)4.47649644
30chromatin remodeling at centromere (GO:0031055)4.38087600
31ionotropic glutamate receptor signaling pathway (GO:0035235)4.37733619
32regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.37663501
33meiotic cell cycle process (GO:1903046)4.37465701
34CENP-A containing nucleosome assembly (GO:0034080)4.35745586
35neuronal action potential propagation (GO:0019227)4.31700255
36neurotransmitter secretion (GO:0007269)4.29072008
37positive regulation of meiotic cell cycle (GO:0051446)4.23505908
38mitotic sister chromatid cohesion (GO:0007064)4.14987082
39mitotic metaphase plate congression (GO:0007080)4.14414185
40regulation of synaptic vesicle transport (GO:1902803)4.12670368
41gamma-aminobutyric acid signaling pathway (GO:0007214)4.08814935
42histone exchange (GO:0043486)4.07697578
43glutamate receptor signaling pathway (GO:0007215)4.07327318
44neuron-neuron synaptic transmission (GO:0007270)4.06627096
45exploration behavior (GO:0035640)4.04115779
46regulation of long-term neuronal synaptic plasticity (GO:0048169)3.99522537
47reciprocal DNA recombination (GO:0035825)3.99322075
48reciprocal meiotic recombination (GO:0007131)3.99322075
49nuclear pore complex assembly (GO:0051292)3.95027948
50nuclear pore organization (GO:0006999)3.94270695
51synaptic transmission, glutamatergic (GO:0035249)3.93280517
52negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.85442727
53negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.85442727
54negative regulation of mitotic sister chromatid segregation (GO:0033048)3.85442727
55negative regulation of mitotic sister chromatid separation (GO:2000816)3.85442727
56negative regulation of sister chromatid segregation (GO:0033046)3.85442727
57regulation of neuronal synaptic plasticity (GO:0048168)3.84173225
58paraxial mesoderm development (GO:0048339)3.82247129
59negative regulation of chromosome segregation (GO:0051985)3.82019740
60presynaptic membrane assembly (GO:0097105)3.81954091
61neuron recognition (GO:0008038)3.80545813
62layer formation in cerebral cortex (GO:0021819)3.79074523
63response to histamine (GO:0034776)3.78188078
64synaptic vesicle docking involved in exocytosis (GO:0016081)3.77734272
65mitotic spindle checkpoint (GO:0071174)3.76392647
66proline transport (GO:0015824)3.76005576
67somatic hypermutation of immunoglobulin genes (GO:0016446)3.74760189
68somatic diversification of immune receptors via somatic mutation (GO:0002566)3.74760189
69neurotransmitter transport (GO:0006836)3.73533901
70sister chromatid cohesion (GO:0007062)3.70613160
71regulation of histone H3-K9 methylation (GO:0051570)3.69150487
72DNA replication checkpoint (GO:0000076)3.68945259
73metaphase plate congression (GO:0051310)3.68078110
74transmission of nerve impulse (GO:0019226)3.66611913
75mitotic spindle assembly checkpoint (GO:0007094)3.65933308
76spindle checkpoint (GO:0031577)3.63209672
77proteasome assembly (GO:0043248)3.62512455
78cellular protein complex localization (GO:0034629)3.62336196
79meiotic cell cycle (GO:0051321)3.62291528
80spindle assembly checkpoint (GO:0071173)3.60864086
81long-term memory (GO:0007616)3.59020633
82centriole assembly (GO:0098534)3.58518211
83synaptic vesicle endocytosis (GO:0048488)3.55387103
84negative regulation of synaptic transmission, GABAergic (GO:0032229)3.55012800
85regulation of excitatory postsynaptic membrane potential (GO:0060079)3.54859878
86DNA replication-independent nucleosome organization (GO:0034724)3.54121524
87DNA replication-independent nucleosome assembly (GO:0006336)3.54121524
88regulation of DNA endoreduplication (GO:0032875)3.51854228
89establishment of integrated proviral latency (GO:0075713)3.51365912
90regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.51033056
91detection of calcium ion (GO:0005513)3.50988957
92regulation of glutamate secretion (GO:0014048)3.50717303
93regulation of postsynaptic membrane potential (GO:0060078)3.49493826
94regulation of neurotransmitter levels (GO:0001505)3.49031501
95mating behavior (GO:0007617)3.48312317
96anterior/posterior axis specification, embryo (GO:0008595)3.47042946
97positive regulation of synaptic transmission, GABAergic (GO:0032230)3.46459998
98mitotic chromosome condensation (GO:0007076)3.46296933
99neuromuscular process controlling posture (GO:0050884)3.44906167
100presynaptic membrane organization (GO:0097090)3.43291894
101regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.41987371
102regulation of mitotic spindle checkpoint (GO:1903504)3.41987371
103dendritic spine morphogenesis (GO:0060997)3.41435514
104activation of protein kinase A activity (GO:0034199)3.41031964
105neurotransmitter-gated ion channel clustering (GO:0072578)3.40981904
106behavioral response to cocaine (GO:0048148)3.39792544
107postsynaptic membrane organization (GO:0001941)3.39717656
108gamma-aminobutyric acid transport (GO:0015812)3.37817245
109positive regulation of membrane potential (GO:0045838)3.36573614
110regulation of vesicle fusion (GO:0031338)3.36369436
111embryonic body morphogenesis (GO:0010172)3.36136019
112long-term synaptic potentiation (GO:0060291)3.35902658
113regulation of posttranscriptional gene silencing (GO:0060147)3.34870778
114regulation of gene silencing by miRNA (GO:0060964)3.34870778
115regulation of gene silencing by RNA (GO:0060966)3.34870778
116regulation of helicase activity (GO:0051095)3.32653003
117regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.32590000
118regulation of mitotic metaphase/anaphase transition (GO:0030071)3.32590000
119protein complex localization (GO:0031503)3.30783468
120protein localization to kinetochore (GO:0034501)3.29803372
121DNA alkylation (GO:0006305)3.28364159
122DNA methylation (GO:0006306)3.28364159
123regulation of mitotic sister chromatid separation (GO:0010965)3.26403575
124regulation of mitotic sister chromatid segregation (GO:0033047)3.26403575
125regulation of sister chromatid segregation (GO:0033045)3.26403575
126regulation of dendritic spine morphogenesis (GO:0061001)3.26073171
127regulation of synaptic transmission, glutamatergic (GO:0051966)3.25934809
128dopamine transport (GO:0015872)3.23941117
129membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.23080106
130striatum development (GO:0021756)3.22448486
131IMP biosynthetic process (GO:0006188)3.21011194
132behavioral defense response (GO:0002209)3.20564444
133behavioral fear response (GO:0001662)3.20564444
134synaptic transmission, dopaminergic (GO:0001963)3.20470526
135positive regulation of synapse maturation (GO:0090129)3.20436227
136DNA double-strand break processing (GO:0000729)3.18537832
137regulation of synaptic plasticity (GO:0048167)3.18366479
138negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.18283877
139prepulse inhibition (GO:0060134)3.18138702
140regulation of synapse structural plasticity (GO:0051823)3.15182028
141regulation of calcium ion-dependent exocytosis (GO:0017158)3.15014637
142negative regulation of DNA-dependent DNA replication (GO:2000104)3.13970267
143axonal fasciculation (GO:0007413)3.13176027
144fear response (GO:0042596)3.13062900
145startle response (GO:0001964)3.11886709
146positive regulation of synapse assembly (GO:0051965)3.10965423
147regulation of mitochondrial translation (GO:0070129)3.10455752
148regulation of protein kinase A signaling (GO:0010738)3.08385960
149catecholamine transport (GO:0051937)3.06745249
150ATP hydrolysis coupled proton transport (GO:0015991)3.06162871
151energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.06162871
152lung-associated mesenchyme development (GO:0060484)3.05860634
153synapse assembly (GO:0007416)3.05796257
154G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.04193599
155regulation of chromosome segregation (GO:0051983)3.03533344
156regulation of neurotransmitter secretion (GO:0046928)2.99552084
157vesicle transport along microtubule (GO:0047496)2.99245462
158G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.98211204
159social behavior (GO:0035176)2.98163383
160intraspecies interaction between organisms (GO:0051703)2.98163383
161synaptic vesicle transport (GO:0048489)2.97676531
162establishment of synaptic vesicle localization (GO:0097480)2.97676531
163negative regulation of mitosis (GO:0045839)2.97355321
164synaptic transmission (GO:0007268)2.96737485
165positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.96580467
166DNA catabolic process, exonucleolytic (GO:0000738)2.96450584
167regulation of meiotic cell cycle (GO:0051445)2.95956885
168negative regulation of dendrite morphogenesis (GO:0050774)2.95785420
169regulation of dopamine metabolic process (GO:0042053)2.95294415
170regulation of catecholamine metabolic process (GO:0042069)2.95294415
171cellular potassium ion homeostasis (GO:0030007)2.94523498
172learning (GO:0007612)2.92896331
173DNA ligation (GO:0006266)2.92889441
174positive regulation of dendritic spine morphogenesis (GO:0061003)2.92689705
175membrane depolarization (GO:0051899)2.92289579
176negative regulation of nuclear division (GO:0051784)2.91144041
177innervation (GO:0060384)2.90845061
178centriole replication (GO:0007099)2.90569234
179attachment of spindle microtubules to kinetochore (GO:0008608)2.90329705
180positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.90162681
181purine nucleobase biosynthetic process (GO:0009113)2.89868633
182negative regulation of neurotransmitter transport (GO:0051589)2.89485337
183regulation of neurotransmitter transport (GO:0051588)2.87543998
184auditory behavior (GO:0031223)2.87490092
185IMP metabolic process (GO:0046040)2.87286679
186negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435)2.85806222
187regulation of meiosis (GO:0040020)2.81985065
188pore complex assembly (GO:0046931)2.81577531
189establishment of protein localization to mitochondrial membrane (GO:0090151)2.79942449
190establishment of chromosome localization (GO:0051303)2.78162569
191embryonic foregut morphogenesis (GO:0048617)2.73738962
192protein localization to chromosome (GO:0034502)2.68907413
193gene silencing (GO:0016458)2.68838372
194mitochondrial DNA replication (GO:0006264)2.68137902
195positive regulation of SMAD protein import into nucleus (GO:0060391)2.68096356
196positive regulation of catenin import into nucleus (GO:0035413)2.68033258
197regulation of centriole replication (GO:0046599)2.67888032
198nuclear division (GO:0000280)2.64689355
199DNA strand elongation involved in DNA replication (GO:0006271)2.64144499
200piRNA metabolic process (GO:0034587)12.1133769

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.10840006
2E2F7_22180533_ChIP-Seq_HELA_Human5.29344892
3SALL1_21062744_ChIP-ChIP_HESCs_Human4.32729953
4GBX2_23144817_ChIP-Seq_PC3_Human3.73007652
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.38204782
6RBPJ_22232070_ChIP-Seq_NCS_Mouse3.16120417
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.15456193
8JARID2_20064375_ChIP-Seq_MESCs_Mouse3.05338445
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.05125456
10FOXM1_23109430_ChIP-Seq_U2OS_Human3.03011874
11REST_21632747_ChIP-Seq_MESCs_Mouse2.82045799
12AR_21909140_ChIP-Seq_LNCAP_Human2.79281622
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.78149749
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.68362508
15HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.65550935
16TAF15_26573619_Chip-Seq_HEK293_Human2.64699145
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.61315240
18TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.57864720
19EZH2_27304074_Chip-Seq_ESCs_Mouse2.54348557
20NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.53975685
21JARID2_20075857_ChIP-Seq_MESCs_Mouse2.53230430
22EZH2_18974828_ChIP-Seq_MESCs_Mouse2.52034369
23RNF2_18974828_ChIP-Seq_MESCs_Mouse2.52034369
24MYC_18555785_ChIP-Seq_MESCs_Mouse2.46375389
25SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.45394167
26FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.44125440
27SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.42988435
28KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.39629056
29KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.39171296
30KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.39171296
31KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.39171296
32RARB_27405468_Chip-Seq_BRAIN_Mouse2.37922358
33CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.36499502
34MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.35054971
35MTF2_20144788_ChIP-Seq_MESCs_Mouse2.34979049
36* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.34787208
37REST_18959480_ChIP-ChIP_MESCs_Mouse2.32596516
38CTBP2_25329375_ChIP-Seq_LNCAP_Human2.31666969
39GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.28632071
40EED_16625203_ChIP-ChIP_MESCs_Mouse2.28613473
41CTBP1_25329375_ChIP-Seq_LNCAP_Human2.16532778
42IKZF1_21737484_ChIP-ChIP_HCT116_Human2.09285900
43ELK1_19687146_ChIP-ChIP_HELA_Human2.03405471
44SUZ12_27294783_Chip-Seq_ESCs_Mouse2.01165292
45GABP_17652178_ChIP-ChIP_JURKAT_Human2.00366153
46RNF2_27304074_Chip-Seq_ESCs_Mouse1.98818966
47EZH2_27294783_Chip-Seq_ESCs_Mouse1.98800651
48CREB1_15753290_ChIP-ChIP_HEK293T_Human1.97833116
49ZNF274_21170338_ChIP-Seq_K562_Hela1.88685164
50POU5F1_16153702_ChIP-ChIP_HESCs_Human1.87532872
51ZFP57_27257070_Chip-Seq_ESCs_Mouse1.86921500
52E2F1_21310950_ChIP-Seq_MCF-7_Human1.86771477
53SMAD4_21799915_ChIP-Seq_A2780_Human1.85783248
54BMI1_23680149_ChIP-Seq_NPCS_Mouse1.84102832
55DROSHA_22980978_ChIP-Seq_HELA_Human1.83375693
56E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.79144905
57CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.76709503
58MYC_19079543_ChIP-ChIP_MESCs_Mouse1.73047335
59ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.71851364
60P300_19829295_ChIP-Seq_ESCs_Human1.69503365
61FUS_26573619_Chip-Seq_HEK293_Human1.63031911
62ERG_21242973_ChIP-ChIP_JURKAT_Human1.59303917
63* IGF1R_20145208_ChIP-Seq_DFB_Human1.58774182
64SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.54512927
65EST1_17652178_ChIP-ChIP_JURKAT_Human1.53471771
66AR_21572438_ChIP-Seq_LNCaP_Human1.52253071
67MYC_19030024_ChIP-ChIP_MESCs_Mouse1.51723530
68PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51574203
69FLI1_27457419_Chip-Seq_LIVER_Mouse1.49594734
70NANOG_16153702_ChIP-ChIP_HESCs_Human1.48878751
71ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.47957623
72POU3F2_20337985_ChIP-ChIP_501MEL_Human1.44589448
73SOX2_16153702_ChIP-ChIP_HESCs_Human1.43985401
74SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.43066094
75VDR_22108803_ChIP-Seq_LS180_Human1.42757406
76CBX2_27304074_Chip-Seq_ESCs_Mouse1.42724748
77TOP2B_26459242_ChIP-Seq_MCF-7_Human1.42640679
78PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.40711819
79SMAD3_21741376_ChIP-Seq_EPCs_Human1.40286255
80NR3C1_23031785_ChIP-Seq_PC12_Mouse1.40074317
81POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.39935983
82FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.39605349
83SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39124859
84MYCN_18555785_ChIP-Seq_MESCs_Mouse1.38617637
85MYC_18940864_ChIP-ChIP_HL60_Human1.37424339
86* RNF2_27304074_Chip-Seq_NSC_Mouse1.37193298
87SOX2_21211035_ChIP-Seq_LN229_Gbm1.36906830
88PIAS1_25552417_ChIP-Seq_VCAP_Human1.36388723
89GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36304801
90NELFA_20434984_ChIP-Seq_ESCs_Mouse1.35616142
91PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.35535132
92OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34780180
93MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.34064089
94RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.31687088
95GATA1_26923725_Chip-Seq_HPCs_Mouse1.31263275
96PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.30893313
97PCGF2_27294783_Chip-Seq_ESCs_Mouse1.29837372
98CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.29443897
99SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28732649
100AR_25329375_ChIP-Seq_VCAP_Human1.28524059
101YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.28483189
102PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.27235581
103MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.26850031
104TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25280519
105ZFX_18555785_ChIP-Seq_MESCs_Mouse1.25237455
106VDR_23849224_ChIP-Seq_CD4+_Human1.24666617
107TCF3_18692474_ChIP-Seq_MEFs_Mouse1.23512354
108STAT3_23295773_ChIP-Seq_U87_Human1.21964163
109RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.21575798
110E2F1_18555785_ChIP-Seq_MESCs_Mouse1.21294408
111* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.21217880
112TCF3_18692474_ChIP-Seq_MESCs_Mouse1.17432566
113RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.17163072
114PADI4_21655091_ChIP-ChIP_MCF-7_Human1.16696396
115TTF2_22483619_ChIP-Seq_HELA_Human1.15931350
116TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.15289440
117RING1B_27294783_Chip-Seq_ESCs_Mouse1.14788309
118DCP1A_22483619_ChIP-Seq_HELA_Human1.13711897
119* RUNX2_22187159_ChIP-Seq_PCA_Human1.11468957
120HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.11334854
121TCF4_23295773_ChIP-Seq_U87_Human1.10908432
122SOX17_20123909_ChIP-Seq_XEN_Mouse1.10789542
123JUN_21703547_ChIP-Seq_K562_Human1.10678502
124SOX2_18555785_ChIP-Seq_MESCs_Mouse1.10408256
125AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.09498785
126FOXP3_21729870_ChIP-Seq_TREG_Human1.09477544
127TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09174209
128AR_19668381_ChIP-Seq_PC3_Human1.07333745
129EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.06604414
130NOTCH1_21737748_ChIP-Seq_TLL_Human1.04789860
131MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03576936
132ER_23166858_ChIP-Seq_MCF-7_Human1.02542147
133JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.02509392
134NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.00799041
135MYC_18358816_ChIP-ChIP_MESCs_Mouse0.99101938
136RING1B_27294783_Chip-Seq_NPCs_Mouse0.98528364
137ARNT_22903824_ChIP-Seq_MCF-7_Human0.98321467
138CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97930270
139NANOG_18555785_Chip-Seq_ESCs_Mouse0.96526397
140YAP1_20516196_ChIP-Seq_MESCs_Mouse0.96471869
141CDX2_19796622_ChIP-Seq_MESCs_Mouse0.96037074
142MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.95204988
143BCAT_22108803_ChIP-Seq_LS180_Human0.94767840
144RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.94230428
145TRIM28_21343339_ChIP-Seq_HEK293_Human0.93950488
146SALL4_18804426_ChIP-ChIP_XEN_Mouse0.93890029
147TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.93272763
148NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.91363060
149NR3C1_21868756_ChIP-Seq_MCF10A_Human0.91315275
150ETS1_20019798_ChIP-Seq_JURKAT_Human0.91107595
151AHR_22903824_ChIP-Seq_MCF-7_Human0.90839454
152PRDM14_20953172_ChIP-Seq_ESCs_Human0.90789839
153P53_22127205_ChIP-Seq_FIBROBLAST_Human0.90581185
154GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.90442634
155SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.90163450
156EWS_26573619_Chip-Seq_HEK293_Human0.89322061
157* SMAD3_21741376_ChIP-Seq_ESCs_Human0.88878581
158CBP_20019798_ChIP-Seq_JUKART_Human0.88785459
159IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.88785459
160CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.88730671
161NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.88527574
162TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88297307
163CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.87705080
164CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.86660656
165ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.86594565
166SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.86352465
167MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.85286784
168WT1_25993318_ChIP-Seq_PODOCYTE_Human0.83923656
169FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.83906704
170DNAJC2_21179169_ChIP-ChIP_NT2_Human0.83368850
171SMAD_19615063_ChIP-ChIP_OVARY_Human0.83120398
172ZNF217_24962896_ChIP-Seq_MCF-7_Human0.82693896

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.39276686
2MP0004859_abnormal_synaptic_plasticity5.08583380
3MP0008058_abnormal_DNA_repair3.94067206
4MP0003195_calcinosis3.83924854
5MP0003635_abnormal_synaptic_transmissio3.83366238
6MP0003941_abnormal_skin_development3.56721592
7MP0009745_abnormal_behavioral_response3.30669420
8MP0004270_analgesia3.14000635
9MP0008057_abnormal_DNA_replication3.11194915
10MP0002063_abnormal_learning/memory/cond3.06508754
11MP0002064_seizures3.03274873
12MP0010094_abnormal_chromosome_stability3.01024546
13MP0004957_abnormal_blastocyst_morpholog2.90984197
14MP0009046_muscle_twitch2.89376459
15MP0003122_maternal_imprinting2.88074326
16MP0003693_abnormal_embryo_hatching2.85118691
17MP0002210_abnormal_sex_determination2.84787033
18MP0001968_abnormal_touch/_nociception2.83594806
19MP0002572_abnormal_emotion/affect_behav2.76230402
20MP0006276_abnormal_autonomic_nervous2.65995474
21MP0001529_abnormal_vocalization2.53103751
22MP0002272_abnormal_nervous_system2.49448868
23MP0001501_abnormal_sleep_pattern2.44886937
24MP0001929_abnormal_gametogenesis2.43899197
25MP0002734_abnormal_mechanical_nocicepti2.40272320
26MP0002822_catalepsy2.40163755
27MP0003111_abnormal_nucleus_morphology2.38814524
28MP0005423_abnormal_somatic_nervous2.36694109
29MP0001440_abnormal_grooming_behavior2.34069148
30MP0003890_abnormal_embryonic-extraembry2.29811552
31MP0001486_abnormal_startle_reflex2.27456839
32MP0003950_abnormal_plasma_membrane2.27162930
33MP0002736_abnormal_nociception_after2.24317141
34MP0003718_maternal_effect2.21756660
35MP0001145_abnormal_male_reproductive2.18775338
36MP0000653_abnormal_sex_gland2.00342171
37MP0002735_abnormal_chemical_nociception1.99638681
38MP0005084_abnormal_gallbladder_morpholo1.98852039
39MP0003698_abnormal_male_reproductive1.96239847
40MP0002733_abnormal_thermal_nociception1.96160274
41MP0002067_abnormal_sensory_capabilities1.93198088
42MP0009697_abnormal_copulation1.91166693
43MP0001905_abnormal_dopamine_level1.90424112
44MP0003077_abnormal_cell_cycle1.89645570
45MP0001970_abnormal_pain_threshold1.88008812
46MP0004924_abnormal_behavior1.84777375
47MP0005386_behavior/neurological_phenoty1.84777375
48MP0005646_abnormal_pituitary_gland1.83913825
49MP0002557_abnormal_social/conspecific_i1.79192752
50MP0002909_abnormal_adrenal_gland1.78664513
51MP0010386_abnormal_urinary_bladder1.74029374
52MP0003937_abnormal_limbs/digits/tail_de1.73686827
53MP0009780_abnormal_chondrocyte_physiolo1.73419891
54MP0002254_reproductive_system_inflammat1.72868122
55MP0003119_abnormal_digestive_system1.71517066
56MP0002837_dystrophic_cardiac_calcinosis1.70583588
57MP0002184_abnormal_innervation1.69217583
58MP0001730_embryonic_growth_arrest1.68945182
59MP0005645_abnormal_hypothalamus_physiol1.68157934
60MP0010368_abnormal_lymphatic_system1.65802775
61MP0004272_abnormal_basement_membrane1.63379313
62MP0003786_premature_aging1.61917160
63MP0001188_hyperpigmentation1.60514601
64MP0000778_abnormal_nervous_system1.59242995
65MP0008932_abnormal_embryonic_tissue1.54242717
66MP0003136_yellow_coat_color1.52697875
67MP0003329_amyloid_beta_deposits1.48945224
68MP0008007_abnormal_cellular_replicative1.48323675
69MP0004142_abnormal_muscle_tone1.47882978
70MP0001984_abnormal_olfaction1.44363514
71MP0002084_abnormal_developmental_patter1.43840355
72MP0002085_abnormal_embryonic_tissue1.41269501
73MP0001697_abnormal_embryo_size1.40858474
74MP0000955_abnormal_spinal_cord1.40684439
75MP0003787_abnormal_imprinting1.38984080
76MP0001915_intracranial_hemorrhage1.37689512
77MP0003123_paternal_imprinting1.36536599
78MP0006292_abnormal_olfactory_placode1.36397062
79MP0006082_CNS_inflammation1.35750637
80MP0002066_abnormal_motor_capabilities/c1.33971917
81MP0001293_anophthalmia1.33767333
82MP0004811_abnormal_neuron_physiology1.33598496
83MP0000013_abnormal_adipose_tissue1.31319621
84MP0008569_lethality_at_weaning1.31244039
85MP0008995_early_reproductive_senescence1.30900546
86MP0009672_abnormal_birth_weight1.30887342
87MP0005380_embryogenesis_phenotype1.30702178
88MP0001672_abnormal_embryogenesis/_devel1.30702178
89MP0004145_abnormal_muscle_electrophysio1.30011806
90MP0003121_genomic_imprinting1.29439113
91MP0003283_abnormal_digestive_organ1.28550274
92MP0004885_abnormal_endolymph1.28525217
93MP0002796_impaired_skin_barrier1.28243868
94MP0003567_abnormal_fetal_cardiomyocyte1.26047057
95MP0009703_decreased_birth_body1.25438722
96MP0002882_abnormal_neuron_morphology1.23525331
97MP0002161_abnormal_fertility/fecundity1.20180528
98MP0001502_abnormal_circadian_rhythm1.16641961
99MP0002160_abnormal_reproductive_system1.16385092
100MP0002233_abnormal_nose_morphology1.13966394
101MP0010030_abnormal_orbit_morphology1.13541043
102MP0000350_abnormal_cell_proliferation1.13462624
103MP0002697_abnormal_eye_size1.12498673
104MP0002876_abnormal_thyroid_physiology1.10454068
105MP0003879_abnormal_hair_cell1.09376441
106MP0003984_embryonic_growth_retardation1.09213792
107MP0004858_abnormal_nervous_system1.07681274
108MP0006072_abnormal_retinal_apoptosis1.05983666
109MP0003633_abnormal_nervous_system1.05441987
110MP0008872_abnormal_physiological_respon1.05371276
111MP0002088_abnormal_embryonic_growth/wei1.03923669
112MP0005379_endocrine/exocrine_gland_phen1.03608716
113MP0001119_abnormal_female_reproductive1.02558805
114MP0010234_abnormal_vibrissa_follicle1.02110003
115MP0002152_abnormal_brain_morphology1.01041658
116MP0005535_abnormal_body_temperature1.00193125
117MP0004197_abnormal_fetal_growth/weight/0.97951693
118MP0005174_abnormal_tail_pigmentation0.97487126
119MP0000631_abnormal_neuroendocrine_gland0.97029609
120MP0004742_abnormal_vestibular_system0.93411117
121MP0003631_nervous_system_phenotype0.93284223
122MP0002080_prenatal_lethality0.92991369
123MP0002069_abnormal_eating/drinking_beha0.92120886
124MP0005409_darkened_coat_color0.91631003
125MP0004085_abnormal_heartbeat0.91067073
126MP0000751_myopathy0.89858978
127MP0001664_abnormal_digestion0.87063053
128MP0002229_neurodegeneration0.86884791
129MP0001286_abnormal_eye_development0.84835448
130MP0005395_other_phenotype0.84069569
131MP0003699_abnormal_female_reproductive0.83621495
132MP0003935_abnormal_craniofacial_develop0.82932625
133MP0002928_abnormal_bile_duct0.82854645
134MP0002086_abnormal_extraembryonic_tissu0.81624196
135MP0009250_abnormal_appendicular_skeleto0.81158399
136MP0005551_abnormal_eye_electrophysiolog0.80304787
137MP0004215_abnormal_myocardial_fiber0.80173695
138MP0003755_abnormal_palate_morphology0.79737398
139MP0004043_abnormal_pH_regulation0.79400154
140MP0001661_extended_life_span0.78971885
141MP0001963_abnormal_hearing_physiology0.78510347
142MP0001299_abnormal_eye_distance/0.76543943
143MP0002102_abnormal_ear_morphology0.75943213
144MP0000762_abnormal_tongue_morphology0.75842415
145MP0002092_abnormal_eye_morphology0.73731186
146MP0003936_abnormal_reproductive_system0.73481049
147MP0005332_abnormal_amino_acid0.72945615
148MP0010307_abnormal_tumor_latency0.70046246
149MP0005501_abnormal_skin_physiology0.69936022
150MP0002752_abnormal_somatic_nervous0.69469976
151MP0003632_abnormal_nervous_system0.68964805
152MP0000428_abnormal_craniofacial_morphol0.68553833
153MP0008874_decreased_physiological_sensi0.68390407
154MP0003385_abnormal_body_wall0.68283895
155MP0000313_abnormal_cell_death0.67607282
156MP0001485_abnormal_pinna_reflex0.66965633
157MP0003943_abnormal_hepatobiliary_system0.66314797
158MP0004484_altered_response_of0.65623177
159MP0002111_abnormal_tail_morphology0.65151457
160MP0003634_abnormal_glial_cell0.64833080
161MP0005389_reproductive_system_phenotype0.64672449
162MP0001879_abnormal_lymphatic_vessel0.64667123
163MP0004133_heterotaxia0.62943988
164MP0002114_abnormal_axial_skeleton0.61768518
165MP0000049_abnormal_middle_ear0.61541816
166MP0001177_atelectasis0.61444301
167MP0005623_abnormal_meninges_morphology0.60660018
168MP0000747_muscle_weakness0.60197258
169MP0005394_taste/olfaction_phenotype0.59437649
170MP0005499_abnormal_olfactory_system0.59437649
171MP0009278_abnormal_bone_marrow0.58883417
172MP0002163_abnormal_gland_morphology0.58718747
173MP0000604_amyloidosis0.57644415
174MP0005167_abnormal_blood-brain_barrier0.57057635
175MP0006035_abnormal_mitochondrial_morpho0.55973271
176MP0001943_abnormal_respiration0.55617196
177MP0003137_abnormal_impulse_conducting0.55193387
178MP0008877_abnormal_DNA_methylation0.54837796
179MP0009379_abnormal_foot_pigmentation0.54594283
180MP0004233_abnormal_muscle_weight0.54315900
181MP0005253_abnormal_eye_physiology0.52706292
182MP0002332_abnormal_exercise_endurance0.52182503
183MP0003861_abnormal_nervous_system0.51419390

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.66149594
2Visual hallucinations (HP:0002367)5.57964584
3Focal seizures (HP:0007359)5.33187216
4Atonic seizures (HP:0010819)5.30805864
5Myokymia (HP:0002411)4.99517935
6Absence seizures (HP:0002121)4.59329907
7Epileptic encephalopathy (HP:0200134)4.55233586
8Volvulus (HP:0002580)4.53566426
9Shoulder girdle muscle weakness (HP:0003547)4.52313019
10Gonadotropin excess (HP:0000837)4.27849106
11Dialeptic seizures (HP:0011146)4.18006549
12Stenosis of the external auditory canal (HP:0000402)4.13451090
13Febrile seizures (HP:0002373)4.05398276
14Generalized tonic-clonic seizures (HP:0002069)3.96455593
15Chromosomal breakage induced by crosslinking agents (HP:0003221)3.63462476
16Hyperventilation (HP:0002883)3.60487955
17Progressive cerebellar ataxia (HP:0002073)3.48513496
18Chromsome breakage (HP:0040012)3.44160523
19Limb dystonia (HP:0002451)3.37935528
20Scotoma (HP:0000575)3.31420522
21Rimmed vacuoles (HP:0003805)3.22736082
22Abnormal lung lobation (HP:0002101)3.22584926
23Broad-based gait (HP:0002136)3.17267389
24Progressive inability to walk (HP:0002505)3.08361522
25Rhabdomyosarcoma (HP:0002859)3.07913680
26Agnosia (HP:0010524)3.06517643
27Amblyopia (HP:0000646)2.95730192
28Anxiety (HP:0000739)2.88997040
29Poor eye contact (HP:0000817)2.86062149
30Impaired vibration sensation in the lower limbs (HP:0002166)2.82780999
31Septo-optic dysplasia (HP:0100842)2.81776776
32Drooling (HP:0002307)2.77190356
33Excessive salivation (HP:0003781)2.77190356
34Acute necrotizing encephalopathy (HP:0006965)2.75583242
35Ectopic kidney (HP:0000086)2.74970384
36Failure to thrive in infancy (HP:0001531)2.72805823
37Truncal ataxia (HP:0002078)2.71564928
38Epileptiform EEG discharges (HP:0011182)2.69956150
39Cerebral inclusion bodies (HP:0100314)2.69386979
40Abnormality of chromosome stability (HP:0003220)2.68551765
41Supranuclear gaze palsy (HP:0000605)2.68383401
42Colon cancer (HP:0003003)2.67601944
43Hyperkalemia (HP:0002153)2.66816252
44Depression (HP:0000716)2.66739777
45Hemiparesis (HP:0001269)2.65784882
46Pheochromocytoma (HP:0002666)2.64064243
47Upper motor neuron abnormality (HP:0002127)2.62874223
48Abnormal eating behavior (HP:0100738)2.61973422
49Biliary tract neoplasm (HP:0100574)2.60195256
50EEG with generalized epileptiform discharges (HP:0011198)2.59542461
51Duodenal stenosis (HP:0100867)2.57458700
52Small intestinal stenosis (HP:0012848)2.57458700
53Abnormal social behavior (HP:0012433)2.57132076
54Impaired social interactions (HP:0000735)2.57132076
55Ankle clonus (HP:0011448)2.56374556
56Meckel diverticulum (HP:0002245)2.54563333
57Progressive macrocephaly (HP:0004481)2.54117071
58Ependymoma (HP:0002888)2.53913372
59Nephroblastoma (Wilms tumor) (HP:0002667)2.53804127
60Polyphagia (HP:0002591)2.52553476
61Dysdiadochokinesis (HP:0002075)2.52331737
62Embryonal renal neoplasm (HP:0011794)2.51544960
63Dysmetria (HP:0001310)2.49336566
64Abnormal mitochondria in muscle tissue (HP:0008316)2.48536420
65Gaze-evoked nystagmus (HP:0000640)2.46356250
66Gout (HP:0001997)2.44609251
67Agitation (HP:0000713)2.41258390
68Inability to walk (HP:0002540)2.40606177
69Bradykinesia (HP:0002067)2.40370549
70Hypsarrhythmia (HP:0002521)2.40338361
71Absent speech (HP:0001344)2.39009476
72Maternal diabetes (HP:0009800)2.38818943
73Abnormality of the ileum (HP:0001549)2.38223750
74Aplasia/Hypoplasia of the uvula (HP:0010293)2.36477216
75Action tremor (HP:0002345)2.34678027
76Urethral obstruction (HP:0000796)2.33066782
77Short middle phalanx of the 5th finger (HP:0004220)2.31108132
78Neurofibrillary tangles (HP:0002185)2.30932802
79Neuroendocrine neoplasm (HP:0100634)2.30622050
80Facial hemangioma (HP:0000329)2.29185721
81Gait imbalance (HP:0002141)2.28006912
82Postural instability (HP:0002172)2.27830116
83Aplasia/Hypoplasia of the sternum (HP:0006714)2.27323106
84Papilledema (HP:0001085)2.26351939
85Urinary bladder sphincter dysfunction (HP:0002839)2.26106997
86Delusions (HP:0000746)2.25200982
87Neoplasm of the colon (HP:0100273)2.24505369
88Abnormality of the duodenum (HP:0002246)2.24444278
89Hyperglycinuria (HP:0003108)2.23682195
90Scanning speech (HP:0002168)2.23405544
91Status epilepticus (HP:0002133)2.23103858
92Central scotoma (HP:0000603)2.21495104
93Abnormality of glycine metabolism (HP:0010895)2.19630422
94Abnormality of serine family amino acid metabolism (HP:0010894)2.19630422
95Generalized myoclonic seizures (HP:0002123)2.19382241
96Reticulocytopenia (HP:0001896)2.18902870
97Progressive external ophthalmoplegia (HP:0000590)2.18281452
98Median cleft lip (HP:0000161)2.16953597
99Spastic gait (HP:0002064)2.16718452
100Absent radius (HP:0003974)2.15858507
101Abnormality of the corticospinal tract (HP:0002492)2.13222190
102Acute encephalopathy (HP:0006846)2.12794734
103Mitochondrial inheritance (HP:0001427)2.12681879
104Neoplasm of the oral cavity (HP:0100649)2.11630063
105Capillary hemangiomas (HP:0005306)2.11021541
106Horizontal nystagmus (HP:0000666)2.06645689
107Abnormality of binocular vision (HP:0011514)2.06402488
108Diplopia (HP:0000651)2.06402488
109Abnormality of the preputium (HP:0100587)2.05711560
110Termporal pattern (HP:0011008)2.05636803
111Insidious onset (HP:0003587)2.05636803
112Medulloblastoma (HP:0002885)2.04901570
113Supernumerary spleens (HP:0009799)2.04635314
114Abnormality of the labia minora (HP:0012880)2.03841018
115Sensory axonal neuropathy (HP:0003390)2.02909420
116Abnormality of the lower motor neuron (HP:0002366)2.02834325
117Impaired smooth pursuit (HP:0007772)2.02232274
118Urinary urgency (HP:0000012)2.02155464
119Esotropia (HP:0000565)2.02101279
120Congenital primary aphakia (HP:0007707)2.01429745
121Hypoplasia of the pons (HP:0012110)2.01156340
122Posterior subcapsular cataract (HP:0007787)1.99802013
123Aplasia involving forearm bones (HP:0009822)1.99570344
124Absent forearm bone (HP:0003953)1.99570344
125Psychosis (HP:0000709)1.99390250
126Osteomalacia (HP:0002749)1.99091101
127Deep philtrum (HP:0002002)1.98991217
128Atrophy/Degeneration involving motor neurons (HP:0007373)1.98571875
129Mutism (HP:0002300)1.97514483
130Protruding tongue (HP:0010808)1.97479809
131Hypoventilation (HP:0002791)1.96804534
132Resting tremor (HP:0002322)1.96462355
133Poor suck (HP:0002033)1.96218740
134Duplication of thumb phalanx (HP:0009942)1.94673446
135Sleep apnea (HP:0010535)1.94105001
136Hyponatremia (HP:0002902)1.93345197
137Increased nuchal translucency (HP:0010880)1.92769667
138Generalized hypotonia (HP:0001290)1.92047231
139Specific learning disability (HP:0001328)1.91747486
140Myelomeningocele (HP:0002475)1.91686352
141Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.91462589
142Vertebral arch anomaly (HP:0008438)1.90896541
143Short tibia (HP:0005736)1.90659208
144Proximal placement of thumb (HP:0009623)1.90010617
145Papillary thyroid carcinoma (HP:0002895)1.88877934
146Blue irides (HP:0000635)1.88240017
147Hypothermia (HP:0002045)1.88185822
148Genital tract atresia (HP:0001827)1.86447852
149Medial flaring of the eyebrow (HP:0010747)1.86430390
150Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.86324718
151Degeneration of the lateral corticospinal tracts (HP:0002314)1.86324718
152Abnormal hair whorl (HP:0010721)1.85397066
153Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.84879509
154Hyperglycinemia (HP:0002154)1.84430984
155Neoplasm of striated muscle (HP:0009728)1.83894018
156Increased circulating renin level (HP:0000848)1.83224704
157Deviation of the thumb (HP:0009603)1.82629004
158Gait ataxia (HP:0002066)1.82624235
159Abnormality of serum amino acid levels (HP:0003112)1.82335470
160Hyperthyroidism (HP:0000836)1.82153480
161Optic nerve hypoplasia (HP:0000609)1.82008087
162Amyotrophic lateral sclerosis (HP:0007354)1.81669163
163Birth length less than 3rd percentile (HP:0003561)1.81465151
164Generalized hypopigmentation of hair (HP:0011358)1.81166123
165Fetal akinesia sequence (HP:0001989)1.80879014
166Vaginal atresia (HP:0000148)1.79139699
167Microvesicular hepatic steatosis (HP:0001414)1.79117755
168Aplasia/Hypoplasia of the tibia (HP:0005772)1.78680972
169Abnormality of ocular smooth pursuit (HP:0000617)1.78377837
170Type II lissencephaly (HP:0007260)1.78353047
171Broad nasal tip (HP:0000455)1.78142371
172Azoospermia (HP:0000027)1.77775391
173Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.76593562
174Lower limb muscle weakness (HP:0007340)1.76246882
175Premature ovarian failure (HP:0008209)1.75934746
176Abnormality of salivation (HP:0100755)1.75715143
177Testicular neoplasm (HP:0010788)1.75542430
178Abnormality of sodium homeostasis (HP:0010931)1.75526148
179Abnormal ciliary motility (HP:0012262)1.74376326
180Choanal atresia (HP:0000453)1.73492524
181Nephrogenic diabetes insipidus (HP:0009806)1.73481157
182Short humerus (HP:0005792)1.73400052
183Exercise-induced muscle cramps (HP:0003710)1.73320695
184Absent eyebrow (HP:0002223)1.72613607
185Sloping forehead (HP:0000340)1.72490767
186Abnormality of the septum pellucidum (HP:0007375)1.72290235
187Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.71978367
188Limb-girdle muscle weakness (HP:0003325)1.71383742
189Aplasia/hypoplasia of the humerus (HP:0006507)1.70805882
190Lip pit (HP:0100267)1.69671092
191Absent septum pellucidum (HP:0001331)1.69534076
192Triphalangeal thumb (HP:0001199)1.68013807
193Abnormality of the pons (HP:0007361)1.66878394
194Hypoplasia of the uterus (HP:0000013)1.65467108

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.57016206
2MAP3K93.88612472
3EPHA43.81541149
4BUB13.41376516
5TTK3.33163115
6PBK3.19395675
7MAP3K123.15353482
8PNCK3.05096365
9MAP3K43.04023766
10ACVR1B2.93850117
11CDC72.89900302
12TAF12.86696027
13STK38L2.76926155
14MAP2K72.64370868
15CASK2.53864709
16MINK12.49369030
17MAP2K42.22343855
18MKNK22.20974208
19ARAF2.18542298
20MARK12.08939448
21KSR22.02623495
22GRK51.87304139
23NTRK11.85123727
24BRD41.80865003
25PLK21.80528278
26SRPK11.76954760
27MST41.75856585
28RIPK41.74787168
29PLK11.68366478
30KSR11.66880513
31BMPR1B1.66415145
32PLK41.65511136
33STK241.62894528
34NEK11.59578959
35DAPK21.59352480
36MKNK11.58481889
37NTRK21.55029646
38WEE11.47060706
39EIF2AK31.46732072
40PAK61.43539630
41TNIK1.42887428
42WNK31.41483032
43DAPK11.41137928
44STK31.41035839
45AKT31.37791213
46CDK51.36668765
47MAP3K131.34955297
48NUAK11.34349797
49CDK191.28666884
50LATS11.28187258
51FES1.27952465
52NME11.25219169
53TRIM281.24399056
54OXSR11.24199742
55MAP3K21.19607740
56CAMK2A1.19317684
57PRKCG1.18692454
58PRKD31.17949320
59MAPK131.16596871
60DMPK1.15890935
61TIE11.11105782
62LATS21.09415758
63UHMK11.07614275
64ZAK1.02090263
65CAMK2B1.01826555
66PDK21.00770337
67CDK81.00634056
68BMPR21.00570780
69VRK11.00297495
70BRSK20.97348351
71VRK20.96840828
72RAF10.94039361
73GRK70.93584740
74FER0.91753010
75CAMKK10.91515731
76STK390.91155869
77ERBB40.91033075
78CHEK20.90634545
79CSNK1G20.89246106
80PASK0.88878625
81TSSK60.88440582
82CDK140.87563962
83CAMKK20.86858132
84PTK2B0.86085172
85CDK180.85510407
86TNK20.84854504
87CDK150.81657494
88BCR0.80227926
89MAPKAPK50.79222453
90BRAF0.79143875
91ADRBK20.77764676
92CAMK2D0.77355288
93ATM0.77085413
94PAK30.75763153
95SIK20.72365301
96CHEK10.72321131
97CDK11A0.70711026
98TYRO30.70134561
99MUSK0.68266003
100ATR0.66560752
101PRKCE0.66098697
102MST1R0.64661596
103MAP3K10.63942585
104PHKG10.63920180
105PHKG20.63920180
106FGR0.63897313
107AURKA0.63853437
108STK380.63281028
109DYRK1A0.62874116
110AURKB0.62572522
111CAMK2G0.62540113
112CAMK10.61884515
113CSNK1G30.60469544
114RET0.59467606
115NEK20.58317512
116STK110.57975946
117FGFR10.56636703
118STK160.56524374
119DYRK30.56296593
120SCYL20.55433430
121ALK0.55302039
122ADRBK10.54552523
123PINK10.54431939
124NEK60.53982170
125CDK30.53791994
126NLK0.53344111
127SGK2230.53146378
128SGK4940.53146378
129SGK10.52424372
130MET0.51087485
131MOS0.51053797
132INSRR0.50759888
133DYRK20.48473610
134PRKCH0.48205808
135WNK40.48023485
136MELK0.47005822
137MAP2K10.46624202
138BRSK10.45461614
139PIK3CG0.45318195
140CDK70.43732858
141CAMK1G0.43015071
142CSNK2A10.43014597
143CDK40.41625792
144CSNK2A20.41058002
145PRPF4B0.40399811
146RPS6KA30.40245157
147LMTK20.39586726
148MYLK0.39234706
149MAPK100.39021049
150SGK20.38918836
151FRK0.38466236
152PRKACA0.38082933
153CDK10.37975112
154YES10.37400413
155CSNK1E0.36082164
156PLK30.35709492
157CDK120.35422558
158CSNK1G10.35081888
159TGFBR10.34721064
160PRKDC0.33747133
161PAK40.33375651
162CDK20.33017177
163NEK90.32861078
164PRKCZ0.32826436
165MAP3K60.32222418
166EIF2AK20.25643331
167PRKG10.25433616
168CLK10.20336394
169PDGFRB0.19987654

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034304.31415701
2Nicotine addiction_Homo sapiens_hsa050334.15266776
3Synaptic vesicle cycle_Homo sapiens_hsa047213.53089343
4DNA replication_Homo sapiens_hsa030303.37379334
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.26614901
6GABAergic synapse_Homo sapiens_hsa047272.83668734
7Non-homologous end-joining_Homo sapiens_hsa034502.82479549
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.81748931
9Cell cycle_Homo sapiens_hsa041102.77626450
10Amphetamine addiction_Homo sapiens_hsa050312.72809220
11Long-term potentiation_Homo sapiens_hsa047202.70650543
12RNA transport_Homo sapiens_hsa030132.56513568
13Nitrogen metabolism_Homo sapiens_hsa009102.55688227
14Basal transcription factors_Homo sapiens_hsa030222.53389955
15Circadian entrainment_Homo sapiens_hsa047132.49032903
16Morphine addiction_Homo sapiens_hsa050322.45123460
17Collecting duct acid secretion_Homo sapiens_hsa049662.41531441
18Glutamatergic synapse_Homo sapiens_hsa047242.39515819
19Proteasome_Homo sapiens_hsa030502.29268068
20Homologous recombination_Homo sapiens_hsa034402.28631001
21Oxidative phosphorylation_Homo sapiens_hsa001902.27763391
22Olfactory transduction_Homo sapiens_hsa047402.26911292
23Base excision repair_Homo sapiens_hsa034102.26634181
24Fanconi anemia pathway_Homo sapiens_hsa034602.25362434
25Dopaminergic synapse_Homo sapiens_hsa047282.24814902
26Insulin secretion_Homo sapiens_hsa049112.15472852
27Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.11394969
28Taste transduction_Homo sapiens_hsa047422.10286199
29Cocaine addiction_Homo sapiens_hsa050302.03997517
30Salivary secretion_Homo sapiens_hsa049702.03526510
31Serotonergic synapse_Homo sapiens_hsa047261.97487172
32Nucleotide excision repair_Homo sapiens_hsa034201.92887311
33Propanoate metabolism_Homo sapiens_hsa006401.90260959
34Vitamin B6 metabolism_Homo sapiens_hsa007501.88305779
35Parkinsons disease_Homo sapiens_hsa050121.85131689
36Long-term depression_Homo sapiens_hsa047301.84835596
37Renin secretion_Homo sapiens_hsa049241.80733781
38Vibrio cholerae infection_Homo sapiens_hsa051101.77159585
39Cholinergic synapse_Homo sapiens_hsa047251.73039240
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.72142929
41Spliceosome_Homo sapiens_hsa030401.70150690
42Alzheimers disease_Homo sapiens_hsa050101.69879020
43Cardiac muscle contraction_Homo sapiens_hsa042601.69282520
44Selenocompound metabolism_Homo sapiens_hsa004501.67945978
45Gastric acid secretion_Homo sapiens_hsa049711.65992307
46Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.64774614
47Aldosterone synthesis and secretion_Homo sapiens_hsa049251.62049853
48Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.59292982
49Calcium signaling pathway_Homo sapiens_hsa040201.57648700
50mRNA surveillance pathway_Homo sapiens_hsa030151.56482776
51Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.54687466
52Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.53751044
53Oxytocin signaling pathway_Homo sapiens_hsa049211.52454503
54RNA degradation_Homo sapiens_hsa030181.48745827
55Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.45741765
56RNA polymerase_Homo sapiens_hsa030201.44458025
57One carbon pool by folate_Homo sapiens_hsa006701.44239698
58Folate biosynthesis_Homo sapiens_hsa007901.42336635
59Pyruvate metabolism_Homo sapiens_hsa006201.41407305
60Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.39481731
61Ribosome_Homo sapiens_hsa030101.39447579
62Gap junction_Homo sapiens_hsa045401.33334663
63TGF-beta signaling pathway_Homo sapiens_hsa043501.31276058
64GnRH signaling pathway_Homo sapiens_hsa049121.28922168
65Huntingtons disease_Homo sapiens_hsa050161.24239252
66Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.20030451
67Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.19340347
68Fatty acid elongation_Homo sapiens_hsa000621.15920949
69Estrogen signaling pathway_Homo sapiens_hsa049151.15018906
70Oocyte meiosis_Homo sapiens_hsa041141.06136803
71Melanogenesis_Homo sapiens_hsa049161.05135157
72p53 signaling pathway_Homo sapiens_hsa041151.03757708
73cAMP signaling pathway_Homo sapiens_hsa040241.02836678
742-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.02470107
75Steroid biosynthesis_Homo sapiens_hsa001001.01223563
76Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.98472811
77Vascular smooth muscle contraction_Homo sapiens_hsa042700.98277740
78Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.97766358
79Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.94091634
80cGMP-PKG signaling pathway_Homo sapiens_hsa040220.91321153
81Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.89697778
82Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.89571216
83Thyroid hormone synthesis_Homo sapiens_hsa049180.86449583
84Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.85968164
85Phosphatidylinositol signaling system_Homo sapiens_hsa040700.84811688
86Type II diabetes mellitus_Homo sapiens_hsa049300.84532380
87Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.83762889
88Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.81896321
89Adherens junction_Homo sapiens_hsa045200.80867551
90Tight junction_Homo sapiens_hsa045300.78806909
91Hippo signaling pathway_Homo sapiens_hsa043900.78700039
92Phototransduction_Homo sapiens_hsa047440.77743682
93Basal cell carcinoma_Homo sapiens_hsa052170.76536124
94Axon guidance_Homo sapiens_hsa043600.75547560
95Pancreatic secretion_Homo sapiens_hsa049720.75230907
96Glioma_Homo sapiens_hsa052140.74447657
97Type I diabetes mellitus_Homo sapiens_hsa049400.73646137
98beta-Alanine metabolism_Homo sapiens_hsa004100.72291158
99Glutathione metabolism_Homo sapiens_hsa004800.70178104
100Glucagon signaling pathway_Homo sapiens_hsa049220.67964317
101ErbB signaling pathway_Homo sapiens_hsa040120.67676869
102Dorso-ventral axis formation_Homo sapiens_hsa043200.66867912
103Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.65352859
104Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.65238598
105Pyrimidine metabolism_Homo sapiens_hsa002400.64118381
106Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62261370
107Purine metabolism_Homo sapiens_hsa002300.62033676
108Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.61515742
109Vitamin digestion and absorption_Homo sapiens_hsa049770.60862933
110Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.60848570
111Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.59559580
112Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.57847175
113Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.57062824
114Alcoholism_Homo sapiens_hsa050340.56914091
115Biosynthesis of amino acids_Homo sapiens_hsa012300.56908280
116N-Glycan biosynthesis_Homo sapiens_hsa005100.56731720
117Dilated cardiomyopathy_Homo sapiens_hsa054140.56026666
118Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.53837781
119Phospholipase D signaling pathway_Homo sapiens_hsa040720.53301990
120Prion diseases_Homo sapiens_hsa050200.53259697
121Renin-angiotensin system_Homo sapiens_hsa046140.52791711
122Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.52571079
123Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.52310167
124Choline metabolism in cancer_Homo sapiens_hsa052310.51859026
125Retinol metabolism_Homo sapiens_hsa008300.51228044
126Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.50854715
127Arginine and proline metabolism_Homo sapiens_hsa003300.50086218
128Lysine degradation_Homo sapiens_hsa003100.47667763
129MAPK signaling pathway_Homo sapiens_hsa040100.45582907
130Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.44983881
131Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.44411567
132Protein export_Homo sapiens_hsa030600.42971685
133Pentose and glucuronate interconversions_Homo sapiens_hsa000400.42198189
134Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.40811515
135Metabolic pathways_Homo sapiens_hsa011000.39169177
136Wnt signaling pathway_Homo sapiens_hsa043100.37018357
137Carbon metabolism_Homo sapiens_hsa012000.36094860
138Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.35820851
139Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.35162802
140Ras signaling pathway_Homo sapiens_hsa040140.34628234
141Inositol phosphate metabolism_Homo sapiens_hsa005620.34400191
142Rheumatoid arthritis_Homo sapiens_hsa053230.33868473
143Regulation of autophagy_Homo sapiens_hsa041400.33744351
144ECM-receptor interaction_Homo sapiens_hsa045120.33554161
145Circadian rhythm_Homo sapiens_hsa047100.33060718
146Ovarian steroidogenesis_Homo sapiens_hsa049130.32663169
147African trypanosomiasis_Homo sapiens_hsa051430.30700572
148Maturity onset diabetes of the young_Homo sapiens_hsa049500.30033889
149Rap1 signaling pathway_Homo sapiens_hsa040150.29749619
150Melanoma_Homo sapiens_hsa052180.29398095
151Carbohydrate digestion and absorption_Homo sapiens_hsa049730.29280769
152Thyroid cancer_Homo sapiens_hsa052160.29177718
153Glycerophospholipid metabolism_Homo sapiens_hsa005640.27228514
154Hedgehog signaling pathway_Homo sapiens_hsa043400.26552693
155Starch and sucrose metabolism_Homo sapiens_hsa005000.25936203
156Insulin signaling pathway_Homo sapiens_hsa049100.25738569
157Bile secretion_Homo sapiens_hsa049760.25418030
158Butanoate metabolism_Homo sapiens_hsa006500.25369335
159Prostate cancer_Homo sapiens_hsa052150.25175178
160Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.25092298
161Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.24841020
162VEGF signaling pathway_Homo sapiens_hsa043700.24481708
163Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.24096558
164mTOR signaling pathway_Homo sapiens_hsa041500.23166133
165Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.22285314
166Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.22216897
167Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.20835795
168Sphingolipid metabolism_Homo sapiens_hsa006000.20334477
169Sphingolipid signaling pathway_Homo sapiens_hsa040710.20123696
170Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.18912316
171Neurotrophin signaling pathway_Homo sapiens_hsa047220.18630499
172Colorectal cancer_Homo sapiens_hsa052100.18436036
173SNARE interactions in vesicular transport_Homo sapiens_hsa041300.17895038
174Pathways in cancer_Homo sapiens_hsa052000.16977207
175Fatty acid degradation_Homo sapiens_hsa000710.15526019

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