DCAF12L2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by Gly-His and Trp-Asp (GH-WD), which may facilitate formation of heterotrimeric or multi-protein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene appears to represent an intronless retrocopy of a related multi-exon gene located on chromosome 9. However, the CDS of this intronless gene remains intact, it is conserved in other mammalian species, it is known to be transcribed, and it is therefore thought to encode a functional protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)5.39308793
2axon ensheathment in central nervous system (GO:0032291)5.39308793
3negative regulation of astrocyte differentiation (GO:0048712)5.13233801
4synapsis (GO:0007129)4.86550882
5pyrimidine nucleobase catabolic process (GO:0006208)4.79849705
6neuron fate determination (GO:0048664)4.33612608
7tongue development (GO:0043586)4.27304364
8negative regulation of synaptic transmission, GABAergic (GO:0032229)4.22490580
9postsynaptic membrane organization (GO:0001941)4.19131181
10radial glial cell differentiation (GO:0060019)4.18891707
11neuron cell-cell adhesion (GO:0007158)4.09830962
12vocalization behavior (GO:0071625)3.98833811
13negative regulation of oligodendrocyte differentiation (GO:0048715)3.97736318
14cerebral cortex neuron differentiation (GO:0021895)3.95580045
15ionotropic glutamate receptor signaling pathway (GO:0035235)3.88692893
16response to nitrosative stress (GO:0051409)3.88367179
17nucleobase catabolic process (GO:0046113)3.71879167
18righting reflex (GO:0060013)3.65779398
19regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.62343143
20regulation of timing of cell differentiation (GO:0048505)3.59923167
21male meiosis I (GO:0007141)3.55438395
22somite development (GO:0061053)3.55418583
23male meiosis (GO:0007140)3.55278900
24presynaptic membrane assembly (GO:0097105)3.53618037
25mitotic sister chromatid cohesion (GO:0007064)3.51945546
26positive regulation of neuroblast proliferation (GO:0002052)3.50198508
27neurotransmitter-gated ion channel clustering (GO:0072578)3.50062565
28piRNA metabolic process (GO:0034587)3.49951540
29retinal rod cell development (GO:0046548)3.48987105
30cilium or flagellum-dependent cell motility (GO:0001539)3.47705527
31negative regulation of glial cell differentiation (GO:0045686)3.47605110
32startle response (GO:0001964)3.47005370
33regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.46663597
34negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.45343055
35glutamate receptor signaling pathway (GO:0007215)3.43473459
36DNA methylation involved in gamete generation (GO:0043046)3.41321317
37protein localization to synapse (GO:0035418)3.40121818
38cranial nerve morphogenesis (GO:0021602)3.39182437
39chromosome organization involved in meiosis (GO:0070192)3.36900715
40regulation of Rac GTPase activity (GO:0032314)3.35077115
41superoxide anion generation (GO:0042554)3.33050011
42positive regulation of cellular amide metabolic process (GO:0034250)3.31569018
43artery development (GO:0060840)3.26974472
44synaptic transmission, glutamatergic (GO:0035249)3.25824302
45layer formation in cerebral cortex (GO:0021819)3.25728330
46G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.25672505
47cornea development in camera-type eye (GO:0061303)3.25639982
48sympathetic nervous system development (GO:0048485)3.19022325
49water-soluble vitamin biosynthetic process (GO:0042364)3.16557965
50positive regulation of action potential (GO:0045760)3.16199683
51epithelial cilium movement (GO:0003351)3.15047551
52olfactory bulb development (GO:0021772)3.11968561
53regulation of glutamate receptor signaling pathway (GO:1900449)3.09294832
54motile cilium assembly (GO:0044458)3.08414142
55regulation of development, heterochronic (GO:0040034)3.07562852
56membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.07127618
57neuron-neuron synaptic transmission (GO:0007270)3.07069274
58presynaptic membrane organization (GO:0097090)3.07015336
59mesenchymal cell differentiation involved in renal system development (GO:2001012)3.05770593
60mesenchymal cell differentiation involved in kidney development (GO:0072161)3.05770593
61positive regulation of synapse assembly (GO:0051965)3.03611872
62positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.01345719
63cerebral cortex radially oriented cell migration (GO:0021799)2.99950099
64gamma-aminobutyric acid signaling pathway (GO:0007214)2.99664906
65regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.99465697
66opioid receptor signaling pathway (GO:0038003)2.99293417
67neuron recognition (GO:0008038)2.99106009
68regulation of synapse maturation (GO:0090128)2.94087999
69urinary tract smooth muscle contraction (GO:0014848)2.93766054
70regulation of astrocyte differentiation (GO:0048710)2.92913401
71positive regulation of synaptic transmission, GABAergic (GO:0032230)2.91938261
72synaptic vesicle docking involved in exocytosis (GO:0016081)2.91085928
73prepulse inhibition (GO:0060134)2.89179734
74sister chromatid cohesion (GO:0007062)2.88883741
75embryonic digestive tract morphogenesis (GO:0048557)2.88205428
76regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.88189015
77positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.86133375
78regulation of respiratory gaseous exchange (GO:0043576)2.85330618
79regulation of inositol phosphate biosynthetic process (GO:0010919)2.84789309
80cholesterol biosynthetic process (GO:0006695)2.84494607
81genitalia morphogenesis (GO:0035112)2.83548621
82inner ear receptor stereocilium organization (GO:0060122)2.83469074
83nonmotile primary cilium assembly (GO:0035058)2.81378450
84spinal cord development (GO:0021510)2.81173334
85regulation of synaptic transmission, glutamatergic (GO:0051966)2.80993490
86meiotic nuclear division (GO:0007126)2.80416320
87retina layer formation (GO:0010842)2.80021761
88negative regulation of transcription regulatory region DNA binding (GO:2000678)2.79499381
89regulation of meiosis I (GO:0060631)2.79406246
90glycosphingolipid biosynthetic process (GO:0006688)2.79017166
91axon extension (GO:0048675)2.77136803
92regulation of glutamate secretion (GO:0014048)2.75424838
93behavioral response to nicotine (GO:0035095)2.74750344
94meiosis I (GO:0007127)2.74170592
95midgut development (GO:0007494)2.73993119
96regulation of respiratory system process (GO:0044065)2.73224554
97response to auditory stimulus (GO:0010996)2.71641881
98negative regulation of homotypic cell-cell adhesion (GO:0034111)2.71033536
99reciprocal meiotic recombination (GO:0007131)2.70907595
100reciprocal DNA recombination (GO:0035825)2.70907595
101reflex (GO:0060004)2.70378794
102cell differentiation involved in kidney development (GO:0061005)2.69898028
103regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.69610217
104regulation of synapse assembly (GO:0051963)2.68719026
105oligodendrocyte differentiation (GO:0048709)2.67629223
106intraciliary transport (GO:0042073)2.67581202
107response to pheromone (GO:0019236)2.65840767
108otic vesicle formation (GO:0030916)2.64814523
109axonemal dynein complex assembly (GO:0070286)2.64456908
110regulation of double-strand break repair via homologous recombination (GO:0010569)2.64437811
111mechanosensory behavior (GO:0007638)2.64075213
112regulation of synaptic transmission, GABAergic (GO:0032228)2.62237415
113eye photoreceptor cell differentiation (GO:0001754)2.61894207
114photoreceptor cell differentiation (GO:0046530)2.61894207
115regulation of activation of Janus kinase activity (GO:0010533)2.60845967
116positive regulation of uterine smooth muscle contraction (GO:0070474)2.60545729
117lung-associated mesenchyme development (GO:0060484)2.60357247
118auditory receptor cell stereocilium organization (GO:0060088)2.57212246
119regulation of dendritic cell antigen processing and presentation (GO:0002604)2.55511459
120regulation of short-term neuronal synaptic plasticity (GO:0048172)2.55213748
121negative regulation of protein localization to cell surface (GO:2000009)2.55007907
122regulation of platelet aggregation (GO:0090330)2.54624721
123central nervous system projection neuron axonogenesis (GO:0021952)2.54554382
124retinal cone cell development (GO:0046549)2.54452583
125drinking behavior (GO:0042756)2.54382038
126negative regulation of skeletal muscle tissue development (GO:0048642)2.53034718
127positive regulation of dendritic spine morphogenesis (GO:0061003)2.52769015
128generation of neurons (GO:0048699)2.52402947
129smoothened signaling pathway (GO:0007224)2.51773607
130peptidyl-cysteine modification (GO:0018198)2.51543050
131regulation of amino acid transport (GO:0051955)2.51169268
132limb bud formation (GO:0060174)2.50693861
133negative regulation of axon guidance (GO:1902668)2.50411450
134synaptic vesicle exocytosis (GO:0016079)2.50165629
135female gonad development (GO:0008585)2.49993618
136sterol biosynthetic process (GO:0016126)2.49977495
137positive regulation of T-helper 1 type immune response (GO:0002827)2.49725591
138polyketide metabolic process (GO:0030638)2.48609527
139doxorubicin metabolic process (GO:0044598)2.48609527
140daunorubicin metabolic process (GO:0044597)2.48609527
141cranial nerve structural organization (GO:0021604)2.48159018
142negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.46667798
143positive regulation of neurotransmitter secretion (GO:0001956)2.46324534
144cerebral cortex cell migration (GO:0021795)2.45933878
145response to histamine (GO:0034776)2.44811073
146establishment of nucleus localization (GO:0040023)2.44545580
147reproductive system development (GO:0061458)2.44008204
148regulation of nuclear cell cycle DNA replication (GO:0033262)2.43923941
149epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.43759120
150regulation of DNA endoreduplication (GO:0032875)2.43431497
151dendrite development (GO:0016358)2.43036430
152cellular anion homeostasis (GO:0030002)2.42627309
153hindbrain development (GO:0030902)2.42606351
154head development (GO:0060322)2.42540524
155synaptonemal complex assembly (GO:0007130)2.42337633
156negative regulation of appetite (GO:0032099)2.41287861
157negative regulation of response to food (GO:0032096)2.41287861
158positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.40908315
159cilium movement (GO:0003341)2.40531918
160hippocampus development (GO:0021766)2.40299783
161central nervous system neuron axonogenesis (GO:0021955)2.40259935
162positive regulation of CREB transcription factor activity (GO:0032793)2.39630645
163neuronal stem cell maintenance (GO:0097150)2.39539925
164behavioral defense response (GO:0002209)2.39527819
165behavioral fear response (GO:0001662)2.39527819
166protein localization to cilium (GO:0061512)2.39258478
167auditory behavior (GO:0031223)2.38958543
168keratinocyte development (GO:0003334)2.38822412
169resolution of meiotic recombination intermediates (GO:0000712)2.37768568
170negative regulation of gliogenesis (GO:0014014)2.37474715
171synaptonemal complex organization (GO:0070193)2.36075957
172negative regulation of heart rate (GO:0010459)2.35416116
173cerebellar granule cell differentiation (GO:0021707)2.35274267
174positive regulation of amino acid transport (GO:0051957)2.35044594
175serotonin receptor signaling pathway (GO:0007210)2.33862792
176forebrain neuron development (GO:0021884)2.33522689
177cell proliferation in forebrain (GO:0021846)2.32162559
178positive regulation of heat generation (GO:0031652)2.30214038
179synapse assembly (GO:0007416)2.30111558
180regulation of non-canonical Wnt signaling pathway (GO:2000050)2.29768631
181microglial cell activation (GO:0001774)2.29502490
182regulation of fever generation (GO:0031620)2.26762194
183neuronal action potential propagation (GO:0019227)2.25957997

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human4.46718740
2EZH2_22144423_ChIP-Seq_EOC_Human4.30873059
3ZNF274_21170338_ChIP-Seq_K562_Hela2.74439838
4ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.72835370
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.69442178
6TAF15_26573619_Chip-Seq_HEK293_Human2.69408419
7SALL1_21062744_ChIP-ChIP_HESCs_Human2.67175918
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.64336763
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.63411885
10EED_16625203_ChIP-ChIP_MESCs_Mouse2.57910492
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.55123845
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.52899420
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.51857293
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.48296756
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.47073745
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.34483087
17RNF2_18974828_ChIP-Seq_MESCs_Mouse2.24346022
18EZH2_18974828_ChIP-Seq_MESCs_Mouse2.24346022
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.22889638
20IGF1R_20145208_ChIP-Seq_DFB_Human2.15206260
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.15148368
22BMI1_23680149_ChIP-Seq_NPCS_Mouse2.15147685
23E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.14582416
24JARID2_20075857_ChIP-Seq_MESCs_Mouse2.12787044
25* CBX2_27304074_Chip-Seq_ESCs_Mouse2.09218779
26P300_19829295_ChIP-Seq_ESCs_Human2.07372094
27IKZF1_21737484_ChIP-ChIP_HCT116_Human2.06812108
28POU3F2_20337985_ChIP-ChIP_501MEL_Human2.04095850
29RBPJ_22232070_ChIP-Seq_NCS_Mouse2.02990295
30FLI1_27457419_Chip-Seq_LIVER_Mouse2.02484342
31PCGF2_27294783_Chip-Seq_ESCs_Mouse1.99145541
32SMAD_19615063_ChIP-ChIP_OVARY_Human1.90460576
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.89750921
34PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.88767667
35EZH2_27294783_Chip-Seq_ESCs_Mouse1.88215576
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.88025796
37RNF2_27304074_Chip-Seq_ESCs_Mouse1.86776433
38PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.83031443
39MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.82414350
40RNF2_27304074_Chip-Seq_NSC_Mouse1.80613976
41SUZ12_27294783_Chip-Seq_ESCs_Mouse1.75016256
42RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.74741414
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.74108297
44MTF2_20144788_ChIP-Seq_MESCs_Mouse1.71877713
45* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.71698268
46HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.71418377
47AR_21572438_ChIP-Seq_LNCaP_Human1.66866665
48SMAD4_21799915_ChIP-Seq_A2780_Human1.66271177
49REST_21632747_ChIP-Seq_MESCs_Mouse1.63527988
50SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.63303171
51CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.61792557
52* FUS_26573619_Chip-Seq_HEK293_Human1.59111642
53SUZ12_27294783_Chip-Seq_NPCs_Mouse1.55672292
54PIAS1_25552417_ChIP-Seq_VCAP_Human1.54000187
55SMAD3_21741376_ChIP-Seq_EPCs_Human1.52490589
56VDR_22108803_ChIP-Seq_LS180_Human1.52255958
57CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.51369145
58NANOG_18555785_Chip-Seq_ESCs_Mouse1.50781732
59EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.48542807
60TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.47718302
61CDX2_19796622_ChIP-Seq_MESCs_Mouse1.47203755
62ER_23166858_ChIP-Seq_MCF-7_Human1.43539452
63TOP2B_26459242_ChIP-Seq_MCF-7_Human1.43485792
64CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42248686
65E2F1_18555785_Chip-Seq_ESCs_Mouse1.40853272
66P53_22387025_ChIP-Seq_ESCs_Mouse1.40553392
67NFE2_27457419_Chip-Seq_LIVER_Mouse1.40542305
68POU5F1_16153702_ChIP-ChIP_HESCs_Human1.39884092
69UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.38463301
70MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.38192115
71SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37884864
72PCGF2_27294783_Chip-Seq_NPCs_Mouse1.35412093
73SUZ12_18555785_Chip-Seq_ESCs_Mouse1.34353021
74CMYC_18555785_Chip-Seq_ESCs_Mouse1.33727430
75AR_25329375_ChIP-Seq_VCAP_Human1.31386185
76EZH2_27294783_Chip-Seq_NPCs_Mouse1.30851264
77OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28333095
78STAT3_18555785_Chip-Seq_ESCs_Mouse1.27831066
79EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.24201388
80AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.23720023
81STAT3_23295773_ChIP-Seq_U87_Human1.23033996
82* EWS_26573619_Chip-Seq_HEK293_Human1.22476882
83FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.20422541
84MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.19636866
85RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.18630854
86P300_18555785_Chip-Seq_ESCs_Mouse1.18039281
87NR3C1_21868756_ChIP-Seq_MCF10A_Human1.17766049
88NMYC_18555785_Chip-Seq_ESCs_Mouse1.17645057
89VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.17456629
90SOX2_18555785_Chip-Seq_ESCs_Mouse1.16970420
91DROSHA_22980978_ChIP-Seq_HELA_Human1.16752245
92* RUNX2_22187159_ChIP-Seq_PCA_Human1.16091962
93TCF4_23295773_ChIP-Seq_U87_Human1.15021724
94TP53_18474530_ChIP-ChIP_U2OS_Human1.14937224
95RUNX1_27457419_Chip-Seq_LIVER_Mouse1.14534054
96JUN_21703547_ChIP-Seq_K562_Human1.14481582
97REST_18959480_ChIP-ChIP_MESCs_Mouse1.14329635
98GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.13312179
99CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.12380662
100POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11965747
101TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11965747
102* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11433690
103TAL1_26923725_Chip-Seq_HPCs_Mouse1.11322818
104SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10840021
105TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10504477
106TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.09780954
107NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.09559091
108RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.09405449
109SOX2_21211035_ChIP-Seq_LN229_Gbm1.09162244
110CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.08974528
111ARNT_22903824_ChIP-Seq_MCF-7_Human1.08825415
112SOX9_26525672_Chip-Seq_HEART_Mouse1.08780262
113PU1_27457419_Chip-Seq_LIVER_Mouse1.08087785
114OCT4_18555785_Chip-Seq_ESCs_Mouse1.07485079
115SOX2_16153702_ChIP-ChIP_HESCs_Human1.06649470
116TBX3_20139965_ChIP-Seq_MESCs_Mouse1.06564052
117TBX3_20139965_ChIP-Seq_ESCs_Mouse1.06478499
118KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.06194970
119TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.04540545
120STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.04539694
121FLI1_21867929_ChIP-Seq_TH2_Mouse1.04356256
122BCAT_22108803_ChIP-Seq_LS180_Human1.02828517
123HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.02304049
124CBP_20019798_ChIP-Seq_JUKART_Human1.02147900
125IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.02147900
126* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01795716
127TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.01220408
128* TCF4_22108803_ChIP-Seq_LS180_Human0.98584365

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.52882447
2MP0002102_abnormal_ear_morphology3.22187735
3MP0006292_abnormal_olfactory_placode3.16954663
4MP0005645_abnormal_hypothalamus_physiol2.77001664
5MP0003787_abnormal_imprinting2.73388976
6MP0003283_abnormal_digestive_organ2.66051676
7MP0002735_abnormal_chemical_nociception2.59501814
8MP0009046_muscle_twitch2.47935073
9MP0001188_hyperpigmentation2.45240116
10MP0002736_abnormal_nociception_after2.35165489
11MP0004859_abnormal_synaptic_plasticity2.32562438
12MP0001486_abnormal_startle_reflex2.29793510
13MP0009745_abnormal_behavioral_response2.28642753
14MP0003122_maternal_imprinting2.25934890
15MP0001968_abnormal_touch/_nociception2.25664606
16MP0003635_abnormal_synaptic_transmissio2.25614171
17MP0003183_abnormal_peptide_metabolism2.23864995
18MP0000566_synostosis2.17208744
19MP0006276_abnormal_autonomic_nervous2.14972371
20MP0005646_abnormal_pituitary_gland2.11131326
21MP0002572_abnormal_emotion/affect_behav2.06322015
22MP0002653_abnormal_ependyma_morphology2.05313670
23MP0001293_anophthalmia2.04974643
24MP0002876_abnormal_thyroid_physiology2.03329206
25MP0002063_abnormal_learning/memory/cond2.02965914
26MP0000383_abnormal_hair_follicle2.01477282
27MP0002064_seizures1.97007138
28MP0005171_absent_coat_pigmentation1.91747634
29MP0002249_abnormal_larynx_morphology1.90068200
30MP0008995_early_reproductive_senescence1.89499768
31MP0002234_abnormal_pharynx_morphology1.86165335
32MP0009697_abnormal_copulation1.84521873
33MP0001440_abnormal_grooming_behavior1.83609526
34MP0003119_abnormal_digestive_system1.82585915
35MP0001501_abnormal_sleep_pattern1.81709854
36MP0002163_abnormal_gland_morphology1.80919226
37MP0003693_abnormal_embryo_hatching1.79096820
38MP0005423_abnormal_somatic_nervous1.77591804
39MP0002282_abnormal_trachea_morphology1.76907306
40MP0000537_abnormal_urethra_morphology1.75415765
41MP0002557_abnormal_social/conspecific_i1.74778010
42MP0002272_abnormal_nervous_system1.74586236
43MP0002734_abnormal_mechanical_nocicepti1.73261952
44MP0002638_abnormal_pupillary_reflex1.72471949
45MP0000427_abnormal_hair_cycle1.70226673
46MP0003937_abnormal_limbs/digits/tail_de1.68750488
47MP0002184_abnormal_innervation1.64000772
48MP0000778_abnormal_nervous_system1.63831262
49MP0002067_abnormal_sensory_capabilities1.62994502
50MP0010678_abnormal_skin_adnexa1.62396943
51MP0004885_abnormal_endolymph1.60850519
52MP0003136_yellow_coat_color1.60662284
53MP0002277_abnormal_respiratory_mucosa1.54626667
54MP0004742_abnormal_vestibular_system1.54450599
55MP0003121_genomic_imprinting1.49187496
56MP0000026_abnormal_inner_ear1.48123209
57MP0009053_abnormal_anal_canal1.46733421
58MP0003879_abnormal_hair_cell1.46720090
59MP0000015_abnormal_ear_pigmentation1.42306212
60MP0001970_abnormal_pain_threshold1.36998614
61MP0002733_abnormal_thermal_nociception1.36961351
62MP0010386_abnormal_urinary_bladder1.36939214
63MP0001963_abnormal_hearing_physiology1.34650855
64MP0004270_analgesia1.34251873
65MP0001346_abnormal_lacrimal_gland1.31551127
66MP0000049_abnormal_middle_ear1.31507047
67MP0001502_abnormal_circadian_rhythm1.30612242
68MP0003123_paternal_imprinting1.28103888
69MP0003938_abnormal_ear_development1.27971689
70MP0005379_endocrine/exocrine_gland_phen1.27918197
71MP0001529_abnormal_vocalization1.27501881
72MP0000516_abnormal_urinary_system1.27413699
73MP0005367_renal/urinary_system_phenotyp1.27413699
74MP0002210_abnormal_sex_determination1.25595095
75MP0001984_abnormal_olfaction1.25245949
76MP0000678_abnormal_parathyroid_gland1.23234099
77MP0008789_abnormal_olfactory_epithelium1.22875596
78MP0003385_abnormal_body_wall1.22692146
79MP0001348_abnormal_lacrimal_gland1.22336381
80MP0002938_white_spotting1.20853947
81MP0003890_abnormal_embryonic-extraembry1.20753341
82MP0004142_abnormal_muscle_tone1.20349921
83MP0002160_abnormal_reproductive_system1.19666701
84MP0008004_abnormal_stomach_pH1.19591770
85MP0004133_heterotaxia1.17070860
86MP0005409_darkened_coat_color1.15647435
87MP0000681_abnormal_thyroid_gland1.13789296
88MP0008058_abnormal_DNA_repair1.10111609
89MP0000647_abnormal_sebaceous_gland1.09764254
90MP0005499_abnormal_olfactory_system1.09504421
91MP0005394_taste/olfaction_phenotype1.09504421
92MP0001929_abnormal_gametogenesis1.05713391
93MP0006082_CNS_inflammation1.05345223
94MP0000579_abnormal_nail_morphology1.04860072
95MP0003941_abnormal_skin_development1.04827563
96MP0001286_abnormal_eye_development1.04712953
97MP0005310_abnormal_salivary_gland1.03446336
98MP0001145_abnormal_male_reproductive1.02393842
99MP0005386_behavior/neurological_phenoty1.01456948
100MP0004924_abnormal_behavior1.01456948
101MP0002090_abnormal_vision1.01304271
102MP0003698_abnormal_male_reproductive1.01051534
103MP0003861_abnormal_nervous_system1.00524037
104MP0001986_abnormal_taste_sensitivity1.00520451
105MP0009780_abnormal_chondrocyte_physiolo0.98654659
106MP0009250_abnormal_appendicular_skeleto0.97348322
107MP0000653_abnormal_sex_gland0.96839080
108MP0002751_abnormal_autonomic_nervous0.95613480
109MP0005195_abnormal_posterior_eye0.94277431
110MP0003567_abnormal_fetal_cardiomyocyte0.94001027
111MP0005391_vision/eye_phenotype0.93977732
112MP0005253_abnormal_eye_physiology0.92549406
113MP0001664_abnormal_digestion0.90849981
114MP0002092_abnormal_eye_morphology0.90670661
115MP0002752_abnormal_somatic_nervous0.90296577
116MP0002152_abnormal_brain_morphology0.88534094
117MP0006072_abnormal_retinal_apoptosis0.88108356
118MP0002066_abnormal_motor_capabilities/c0.87315420
119MP0002882_abnormal_neuron_morphology0.86349635
120MP0001905_abnormal_dopamine_level0.85925628
121MP0010030_abnormal_orbit_morphology0.85239261
122MP0005551_abnormal_eye_electrophysiolog0.84814053
123MP0004782_abnormal_surfactant_physiolog0.83868833
124MP0005187_abnormal_penis_morphology0.83409651
125MP0000631_abnormal_neuroendocrine_gland0.83263555
126MP0008877_abnormal_DNA_methylation0.82860771
127MP0000428_abnormal_craniofacial_morphol0.81803918
128MP0003195_calcinosis0.81469906
129MP0002697_abnormal_eye_size0.81349560
130MP0002177_abnormal_outer_ear0.81333329
131MP0001299_abnormal_eye_distance/0.81086409
132MP0005248_abnormal_Harderian_gland0.75066481
133MP0002148_abnormal_hypersensitivity_rea0.74281657
134MP0001119_abnormal_female_reproductive0.72029712
135MP0000955_abnormal_spinal_cord0.71671071
136MP0008569_lethality_at_weaning0.71592580
137MP0002233_abnormal_nose_morphology0.71183209
138MP0001177_atelectasis0.71008648
139MP0002116_abnormal_craniofacial_bone0.70427371
140MP0003315_abnormal_perineum_morphology0.69488377
141MP0004510_myositis0.68254585
142MP0003755_abnormal_palate_morphology0.67063833
143MP0004134_abnormal_chest_morphology0.64387369
144MP0008260_abnormal_autophagy0.62132172
145MP0001485_abnormal_pinna_reflex0.61406746

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.25494827
2Dynein arm defect of respiratory motile cilia (HP:0012255)4.79191601
3Absent/shortened dynein arms (HP:0200106)4.79191601
4Abnormal ciliary motility (HP:0012262)4.39507077
5Oligodactyly (hands) (HP:0001180)4.17423723
6Oligodactyly (HP:0012165)4.05200242
7Febrile seizures (HP:0002373)3.99843120
8Gonadotropin excess (HP:0000837)3.56672627
9Aplasia cutis congenita (HP:0001057)3.51476440
10Abnormal respiratory epithelium morphology (HP:0012253)3.47727030
11Abnormal respiratory motile cilium morphology (HP:0005938)3.47727030
12Hyperventilation (HP:0002883)3.44803886
13Facial hemangioma (HP:0000329)3.37318432
14Epileptic encephalopathy (HP:0200134)3.35322741
15Abnormal respiratory motile cilium physiology (HP:0012261)3.29234854
16Abnormality of the labia minora (HP:0012880)3.24707667
17White forelock (HP:0002211)3.03954459
18Hypoplastic left heart (HP:0004383)3.00212018
19Abnormality of the nasal septum (HP:0000419)2.99551224
20Chronic hepatic failure (HP:0100626)2.88766634
21Septo-optic dysplasia (HP:0100842)2.84939557
22Aplasia/Hypoplasia of the sternum (HP:0006714)2.83767503
23Abnormality of incisor morphology (HP:0011063)2.81875866
24Abnormality of the 1st metacarpal (HP:0010009)2.80066981
25Abnormality of the metopic suture (HP:0005556)2.79101885
26True hermaphroditism (HP:0010459)2.77611971
27Patchy hypopigmentation of hair (HP:0011365)2.77163652
28Volvulus (HP:0002580)2.74756021
29Abnormal hair whorl (HP:0010721)2.67458873
30Hypoplastic heart (HP:0001961)2.63895822
31Amyotrophic lateral sclerosis (HP:0007354)2.60412486
32Occipital encephalocele (HP:0002085)2.60020438
33Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.56442510
34Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.54152097
35Short 1st metacarpal (HP:0010034)2.54152097
36Rib fusion (HP:0000902)2.54034765
37Limb dystonia (HP:0002451)2.53175578
38Atonic seizures (HP:0010819)2.44803113
39Gait imbalance (HP:0002141)2.43522941
40Hypothermia (HP:0002045)2.42339190
41Nephrogenic diabetes insipidus (HP:0009806)2.41751892
42Medial flaring of the eyebrow (HP:0010747)2.41558711
43Ectopic kidney (HP:0000086)2.41342971
44Colon cancer (HP:0003003)2.40838513
45Preauricular pit (HP:0004467)2.39247650
46Periauricular skin pits (HP:0100277)2.39247650
47Nasolacrimal duct obstruction (HP:0000579)2.39107735
48Genital tract atresia (HP:0001827)2.37384850
49Absent septum pellucidum (HP:0001331)2.36767856
50Methylmalonic acidemia (HP:0002912)2.36565472
51Vaginal atresia (HP:0000148)2.34971678
52Tubulointerstitial nephritis (HP:0001970)2.31572436
53Chromosomal breakage induced by crosslinking agents (HP:0003221)2.30021249
54Thyroid-stimulating hormone excess (HP:0002925)2.29717068
55Cortical dysplasia (HP:0002539)2.28298041
56Congenital primary aphakia (HP:0007707)2.24492402
57Focal seizures (HP:0007359)2.23688156
58Hyperglycinemia (HP:0002154)2.23315662
59Maternal diabetes (HP:0009800)2.22681155
60Renal hypoplasia (HP:0000089)2.20946322
61Anomalous pulmonary venous return (HP:0010772)2.19688868
62Abnormality of the lower motor neuron (HP:0002366)2.18848448
63Nephronophthisis (HP:0000090)2.16866898
64Postaxial foot polydactyly (HP:0001830)2.16105357
65Deep philtrum (HP:0002002)2.15155888
66Retrobulbar optic neuritis (HP:0100654)2.14941191
67Optic neuritis (HP:0100653)2.14941191
68Nasal speech (HP:0001611)2.14716891
69Blue irides (HP:0000635)2.14484872
70Generalized tonic-clonic seizures (HP:0002069)2.14282249
71Abnormality of the septum pellucidum (HP:0007375)2.14073862
72Postaxial hand polydactyly (HP:0001162)2.13649183
73Supernumerary spleens (HP:0009799)2.13338329
74Poor coordination (HP:0002370)2.12840339
75Bell-shaped thorax (HP:0001591)2.09807444
76Congenital sensorineural hearing impairment (HP:0008527)2.09161004
77Exotropia (HP:0000577)2.08983594
78Morphological abnormality of the middle ear (HP:0008609)2.08382621
79Hypoplastic pelvis (HP:0008839)2.08255285
80Increased hepatocellular lipid droplets (HP:0006565)2.06834764
81Rimmed vacuoles (HP:0003805)2.06369098
82Duplication of thumb phalanx (HP:0009942)2.05500510
83Preaxial hand polydactyly (HP:0001177)2.05159791
84Decreased testicular size (HP:0008734)2.04941577
85Pancreatic fibrosis (HP:0100732)2.00534931
86Intestinal atresia (HP:0011100)2.00471493
87Absent speech (HP:0001344)1.99795095
88Absence seizures (HP:0002121)1.99484521
89Protruding tongue (HP:0010808)1.97958102
90Aplasia/Hypoplasia of the lens (HP:0008063)1.97176151
91Excessive salivation (HP:0003781)1.96810932
92Drooling (HP:0002307)1.96810932
93Optic nerve hypoplasia (HP:0000609)1.96745327
94Abnormality of the aortic arch (HP:0012303)1.96476691
95Labial hypoplasia (HP:0000066)1.94021721
96Preaxial foot polydactyly (HP:0001841)1.93312692
97Conical tooth (HP:0000698)1.93145814
98Aplasia/Hypoplasia of the tongue (HP:0010295)1.92892172
99Abnormality of the lacrimal duct (HP:0011481)1.92744953
100Anophthalmia (HP:0000528)1.92210708
101Abnormality of the pulmonary veins (HP:0011718)1.92161959
102Fibular aplasia (HP:0002990)1.90011657
103Rhinitis (HP:0012384)1.88208787
104Polyphagia (HP:0002591)1.88189526
105Neonatal short-limb short stature (HP:0008921)1.87424507
106Broad foot (HP:0001769)1.86325507
107Chromsome breakage (HP:0040012)1.85583707
108Gastroesophageal reflux (HP:0002020)1.84859773
109Abnormality of salivation (HP:0100755)1.83410852
110Lipid accumulation in hepatocytes (HP:0006561)1.83338878
111Cutaneous finger syndactyly (HP:0010554)1.83220502
112Abnormality of the intervertebral disk (HP:0005108)1.82797025
113Tetany (HP:0001281)1.82256333
114Fibular hypoplasia (HP:0003038)1.81873490
115Amelogenesis imperfecta (HP:0000705)1.81541648
116Hyperphosphatemia (HP:0002905)1.81191104
117Hypoplastic iliac wings (HP:0002866)1.81140316
118High anterior hairline (HP:0009890)1.80740879
119Short tibia (HP:0005736)1.80481530
120Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.78768305
121Specific learning disability (HP:0001328)1.78520170
122Male pseudohermaphroditism (HP:0000037)1.78386406
123Esotropia (HP:0000565)1.78249175
124Shoulder girdle muscle weakness (HP:0003547)1.77648377
125Triphalangeal thumb (HP:0001199)1.77403731
126Dialeptic seizures (HP:0011146)1.77151282
127Lissencephaly (HP:0001339)1.76147767
128Short hallux (HP:0010109)1.75400805
129Hypoplastic female external genitalia (HP:0012815)1.74962873
130Hepatoblastoma (HP:0002884)1.74874686
131Cutaneous syndactyly (HP:0012725)1.74645661
132Pancreatic cysts (HP:0001737)1.74446712
133Abnormal eating behavior (HP:0100738)1.74353208
134Abnormality of the phalanges of the hallux (HP:0010057)1.74036243
135Aplasia/Hypoplasia of the fibula (HP:0006492)1.73785282
136Fair hair (HP:0002286)1.73733774
137Broad-based gait (HP:0002136)1.73669655
138Micropenis (HP:0000054)1.73578840
139Gastrointestinal atresia (HP:0002589)1.73242438
140Abnormality of the phalanges of the 5th finger (HP:0004213)1.72733293
141Abnormality of the nasolacrimal system (HP:0000614)1.72090973
142Parakeratosis (HP:0001036)1.70561765
143Short foot (HP:0001773)1.70123151
144Abnormal lung lobation (HP:0002101)1.69963065
145Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.69487063
146Aplasia/Hypoplasia of the fovea (HP:0008060)1.69214650
147Hypoplasia of the fovea (HP:0007750)1.69214650
148Congenital malformation of the right heart (HP:0011723)1.68394706
149Double outlet right ventricle (HP:0001719)1.68394706
150Short phalanx of the thumb (HP:0009660)1.68340955
151Aplasia/Hypoplasia of the hallux (HP:0008362)1.67942937
152Esophageal atresia (HP:0002032)1.67516922
153Astigmatism (HP:0000483)1.67196155
154Diastasis recti (HP:0001540)1.67129490
155Decreased central vision (HP:0007663)1.65958866
156Gaze-evoked nystagmus (HP:0000640)1.65853079
157Prominent metopic ridge (HP:0005487)1.65146218
158Hypoplastic ilia (HP:0000946)1.64968046
159Multicystic kidney dysplasia (HP:0000003)1.64894784
160Sclerocornea (HP:0000647)1.63883072
161Lip pit (HP:0100267)1.63372981
162Aplasia/Hypoplasia of the tibia (HP:0005772)1.63194493
163Abnormality of the renal medulla (HP:0100957)1.62902263
164Overfolded helix (HP:0000396)1.62848610
165Meckel diverticulum (HP:0002245)1.62423379
166Atrophy/Degeneration involving motor neurons (HP:0007373)1.62349276
167Duplicated collecting system (HP:0000081)1.62081262
168Primary amenorrhea (HP:0000786)1.61264970
169Small hand (HP:0200055)1.61168072
170Microglossia (HP:0000171)1.60236093
171Abnormality of the pubic bones (HP:0003172)1.60068048

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.55451843
2PNCK5.08120726
3MAP4K24.89807198
4SIK33.97870653
5BLK3.89215953
6TRIM283.26410279
7TNIK3.21062231
8PRKD32.78965191
9MKNK22.76113099
10MAPK132.31147335
11MAP2K72.29631584
12BMPR22.23931634
13TAF12.15549634
14MUSK2.08723990
15NTRK31.95825513
16WEE11.94074404
17TSSK61.79943925
18PLK21.79040715
19MARK11.78351638
20PRPF4B1.78056186
21WNK31.77925729
22ADRBK21.76691902
23MAP3K141.74593235
24ERBB31.73280522
25NEK61.71577044
26YES11.62254638
27MET1.59794911
28AKT31.57639742
29MKNK11.54365601
30BMPR1B1.49697671
31TXK1.48144798
32PIK3CA1.39245405
33BCR1.36936421
34KSR11.32818681
35EPHA41.31610605
36MAP3K121.22309319
37NTRK21.21409054
38EIF2AK21.16388162
39CSNK1G11.16385303
40DAPK21.14251684
41IRAK11.12631505
42SGK21.05772725
43PKN11.05327031
44CDC71.04305791
45STK161.02853726
46MAP3K91.02657495
47FGR1.01792669
48IRAK41.01563346
49MAPK151.01516822
50CSNK1G31.00772343
51NUAK11.00342057
52PLK31.00252720
53RIPK40.99902721
54SIK20.99358380
55PRKCE0.97718374
56ZAK0.93491226
57EPHA30.93418510
58INSRR0.92857373
59GRK70.92375225
60MOS0.91374680
61STK38L0.89729101
62PKN20.89413870
63CSNK1A1L0.87751184
64PDK20.87637014
65CDK80.87035113
66MAP3K40.86867149
67CDK30.81763356
68CAMK2A0.81539137
69STK240.79963763
70DYRK1A0.78395461
71NME10.76548162
72DYRK20.73646863
73MINK10.73544833
74FRK0.73435998
75BRSK20.71834418
76PRKCG0.71655723
77SGK2230.70024673
78SGK4940.70024673
79BMX0.70008884
80EPHB20.69803108
81TAOK20.69454325
82ARAF0.69096009
83ERBB40.68956433
84BRAF0.67787867
85ADRBK10.66029647
86ATR0.64087220
87DYRK30.63965246
88PIK3CG0.62994067
89NLK0.62867084
90DYRK1B0.62443647
91OXSR10.61439271
92FGFR20.59933937
93FES0.59164853
94GRK50.57337153
95TYRO30.56703610
96CDC42BPA0.54788241
97PRKG10.53183530
98BRSK10.52466113
99PLK10.51545219
100VRK20.50739168
101TNK20.50506868
102RAF10.50452567
103CDK50.49700150
104FLT30.49464661
105MAPKAPK50.49453281
106CAMK2B0.48961044
107DAPK10.48228901
108SGK10.45962696
109STK110.45952641
110CSNK1G20.45239280
111IRAK30.45055201
112ATM0.43690983
113SGK30.43325764
114RPS6KB10.42645662
115OBSCN0.42569353
116PRKACA0.40819321
117PTK2B0.40481743
118PAK60.40238909
119CDK180.40135226
120CSNK1A10.39751688
121CCNB10.39275350
122LYN0.37571918
123CSNK1E0.35339036
124UHMK10.35205571
125CDK11A0.35122838
126GRK10.34884613
127FER0.34655014
128STK30.34245852
129PIM20.33918195
130IKBKB0.33668360
131CAMKK10.33423460
132PHKG20.33142835
133PHKG10.33142835
134CAMK1G0.33135214
135CDK150.32664215
136MAPK70.32630625
137PAK30.32327433
138CAMK40.32212241
139PRKCZ0.32210342
140SRPK10.30730853
141IRAK20.30603569
142PINK10.30347345
143CDK190.29081573
144FYN0.28942833
145ROCK10.28137678
146VRK10.27850953

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.38142085
2Steroid biosynthesis_Homo sapiens_hsa001003.14117234
3Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.75791766
4Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.52920480
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.48769698
6Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.48757050
7Morphine addiction_Homo sapiens_hsa050322.41524466
8GABAergic synapse_Homo sapiens_hsa047272.20802605
9Synaptic vesicle cycle_Homo sapiens_hsa047212.18114566
10Collecting duct acid secretion_Homo sapiens_hsa049662.14708419
11Basal transcription factors_Homo sapiens_hsa030222.14465698
12Glutamatergic synapse_Homo sapiens_hsa047242.05568521
13Rheumatoid arthritis_Homo sapiens_hsa053232.01084309
14Serotonergic synapse_Homo sapiens_hsa047262.00532097
15Olfactory transduction_Homo sapiens_hsa047401.98973554
16Circadian entrainment_Homo sapiens_hsa047131.95410778
17Taste transduction_Homo sapiens_hsa047421.93049815
18Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.89963311
19Hedgehog signaling pathway_Homo sapiens_hsa043401.88990809
20Homologous recombination_Homo sapiens_hsa034401.85189998
21Propanoate metabolism_Homo sapiens_hsa006401.83854496
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.81480635
23Autoimmune thyroid disease_Homo sapiens_hsa053201.67675751
24Allograft rejection_Homo sapiens_hsa053301.66155929
25Butanoate metabolism_Homo sapiens_hsa006501.63401042
26Type I diabetes mellitus_Homo sapiens_hsa049401.63075340
27Calcium signaling pathway_Homo sapiens_hsa040201.54843484
28Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.54660703
29Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.49917535
30Graft-versus-host disease_Homo sapiens_hsa053321.48728459
31Amphetamine addiction_Homo sapiens_hsa050311.46497842
32Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.43821460
33Phagosome_Homo sapiens_hsa041451.42417939
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.40657140
35Insulin secretion_Homo sapiens_hsa049111.37960499
36Intestinal immune network for IgA production_Homo sapiens_hsa046721.35941085
37SNARE interactions in vesicular transport_Homo sapiens_hsa041301.35071159
38Melanoma_Homo sapiens_hsa052181.32506547
39Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.30174270
40Renin secretion_Homo sapiens_hsa049241.24967025
41Salivary secretion_Homo sapiens_hsa049701.24531821
42Asthma_Homo sapiens_hsa053101.23761929
43Axon guidance_Homo sapiens_hsa043601.23292836
44Dopaminergic synapse_Homo sapiens_hsa047281.20138885
45Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.18835423
46Phototransduction_Homo sapiens_hsa047441.18552510
47Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.17665138
48Mismatch repair_Homo sapiens_hsa034301.17578483
49Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.15309914
50RNA degradation_Homo sapiens_hsa030181.15202915
51Vibrio cholerae infection_Homo sapiens_hsa051101.14401167
52Nucleotide excision repair_Homo sapiens_hsa034201.13899283
53Long-term depression_Homo sapiens_hsa047301.10780825
54Cholinergic synapse_Homo sapiens_hsa047251.07683476
55Hippo signaling pathway_Homo sapiens_hsa043901.06266612
56Regulation of autophagy_Homo sapiens_hsa041401.05634578
57Oocyte meiosis_Homo sapiens_hsa041141.04793302
58TGF-beta signaling pathway_Homo sapiens_hsa043501.04619144
59Oxidative phosphorylation_Homo sapiens_hsa001901.03654385
60Cocaine addiction_Homo sapiens_hsa050301.03138066
61Oxytocin signaling pathway_Homo sapiens_hsa049211.00620661
62RNA transport_Homo sapiens_hsa030131.00599286
63Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.99568344
64Peroxisome_Homo sapiens_hsa041460.99280366
65Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.96131111
66Long-term potentiation_Homo sapiens_hsa047200.96044678
67Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.95145897
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.94953592
69Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.91308209
70Maturity onset diabetes of the young_Homo sapiens_hsa049500.89024167
71Fat digestion and absorption_Homo sapiens_hsa049750.88027151
72Arginine and proline metabolism_Homo sapiens_hsa003300.87988549
73Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.87631751
74Ras signaling pathway_Homo sapiens_hsa040140.87356178
75beta-Alanine metabolism_Homo sapiens_hsa004100.86696540
76Cysteine and methionine metabolism_Homo sapiens_hsa002700.86104412
77Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.85523036
78Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.85447504
79Cell cycle_Homo sapiens_hsa041100.85347243
80Gastric acid secretion_Homo sapiens_hsa049710.85099298
81cAMP signaling pathway_Homo sapiens_hsa040240.84884583
82mRNA surveillance pathway_Homo sapiens_hsa030150.84446421
83African trypanosomiasis_Homo sapiens_hsa051430.83957367
84Pyruvate metabolism_Homo sapiens_hsa006200.83823573
85Vitamin digestion and absorption_Homo sapiens_hsa049770.83420018
86Vitamin B6 metabolism_Homo sapiens_hsa007500.83228916
87Cardiac muscle contraction_Homo sapiens_hsa042600.81591082
88Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.80981535
89Dilated cardiomyopathy_Homo sapiens_hsa054140.79235714
90Spliceosome_Homo sapiens_hsa030400.78021923
91NF-kappa B signaling pathway_Homo sapiens_hsa040640.77576160
92Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.77504553
93Fatty acid degradation_Homo sapiens_hsa000710.77279321
94Aldosterone synthesis and secretion_Homo sapiens_hsa049250.76572846
95Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.75702151
96Fatty acid metabolism_Homo sapiens_hsa012120.75131459
97Ether lipid metabolism_Homo sapiens_hsa005650.74791621
98Biosynthesis of amino acids_Homo sapiens_hsa012300.74648809
99Arachidonic acid metabolism_Homo sapiens_hsa005900.72139653
100Base excision repair_Homo sapiens_hsa034100.71306363
101Protein export_Homo sapiens_hsa030600.65842604
102cGMP-PKG signaling pathway_Homo sapiens_hsa040220.65718128
103Ovarian steroidogenesis_Homo sapiens_hsa049130.64541270
104Hematopoietic cell lineage_Homo sapiens_hsa046400.64275730
105Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.63838908
106MAPK signaling pathway_Homo sapiens_hsa040100.63825979
107PPAR signaling pathway_Homo sapiens_hsa033200.63470414
108Non-homologous end-joining_Homo sapiens_hsa034500.62916927
109Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.62638762
110Alzheimers disease_Homo sapiens_hsa050100.62517625
111Tuberculosis_Homo sapiens_hsa051520.62185337
112Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.61374486
113Staphylococcus aureus infection_Homo sapiens_hsa051500.60610778
114Type II diabetes mellitus_Homo sapiens_hsa049300.60301461
115DNA replication_Homo sapiens_hsa030300.60220468
116Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.59048370
117Fanconi anemia pathway_Homo sapiens_hsa034600.58543036
118RNA polymerase_Homo sapiens_hsa030200.58068755
119Vascular smooth muscle contraction_Homo sapiens_hsa042700.57432439
120Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.56766616
121Toll-like receptor signaling pathway_Homo sapiens_hsa046200.56726882
122Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.56135537
123Rap1 signaling pathway_Homo sapiens_hsa040150.55529435
124Measles_Homo sapiens_hsa051620.55470672
125Nitrogen metabolism_Homo sapiens_hsa009100.53728193
126Wnt signaling pathway_Homo sapiens_hsa043100.53589010
127Selenocompound metabolism_Homo sapiens_hsa004500.53484006
128Jak-STAT signaling pathway_Homo sapiens_hsa046300.53212272
129Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.52208741
130alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.51483491
131Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.51269282
132Tight junction_Homo sapiens_hsa045300.50595097
133Metabolic pathways_Homo sapiens_hsa011000.50230775
134Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.49313299
135ErbB signaling pathway_Homo sapiens_hsa040120.49224671
136RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.49004073
137Folate biosynthesis_Homo sapiens_hsa007900.48403800
138Carbon metabolism_Homo sapiens_hsa012000.47831596
139Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.46772947
140Alcoholism_Homo sapiens_hsa050340.44835255
141Chemokine signaling pathway_Homo sapiens_hsa040620.44553929
142Melanogenesis_Homo sapiens_hsa049160.44149838
143Fatty acid elongation_Homo sapiens_hsa000620.44104932
144Circadian rhythm_Homo sapiens_hsa047100.43979023
145Caffeine metabolism_Homo sapiens_hsa002320.43934197
146Leishmaniasis_Homo sapiens_hsa051400.43860272
147Regulation of actin cytoskeleton_Homo sapiens_hsa048100.43647200
148Huntingtons disease_Homo sapiens_hsa050160.43557829
149Steroid hormone biosynthesis_Homo sapiens_hsa001400.42813268
150Parkinsons disease_Homo sapiens_hsa050120.42421158
151Arginine biosynthesis_Homo sapiens_hsa002200.41837610
152NOD-like receptor signaling pathway_Homo sapiens_hsa046210.40528905
153Chemical carcinogenesis_Homo sapiens_hsa052040.40389843
154Gap junction_Homo sapiens_hsa045400.39270094
155Basal cell carcinoma_Homo sapiens_hsa052170.37808057
156Legionellosis_Homo sapiens_hsa051340.37286497
157Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.35398078
158TNF signaling pathway_Homo sapiens_hsa046680.34058412
159Malaria_Homo sapiens_hsa051440.33727605
160Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.31364614

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »