ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	leukotriene biosynthetic process (GO:0019370)	7.17760021
2	DNA deamination (GO:0045006)	6.41982021
3	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	6.22455504
4	regulation of chronic inflammatory response (GO:0002676)	5.79523501
5	response to pheromone (GO:0019236)	5.50810755
6	nonribosomal peptide biosynthetic process (GO:0019184)	5.46904914
7	cytidine deamination (GO:0009972)	5.25369644
8	cytidine metabolic process (GO:0046087)	5.25369644
9	cytidine catabolic process (GO:0006216)	5.25369644
10	glutathione biosynthetic process (GO:0006750)	5.23186743
11	ribosome assembly (GO:0042255)	5.21852342
12	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	5.05577726
13	proteasome assembly (GO:0043248)	4.90090158
14	negative regulation by host of viral transcription (GO:0043922)	4.54508278
15	regulation of isotype switching to IgG isotypes (GO:0048302)	4.53016518
16	pyrimidine ribonucleoside catabolic process (GO:0046133)	4.52656789
17	transcription from mitochondrial promoter (GO:0006390)	4.50455153
18	regulation of podosome assembly (GO:0071801)	4.47338494
19	negative regulation of T-helper cell differentiation (GO:0045623)	4.31466797
20	negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)	4.31466797
21	interferon-gamma secretion (GO:0072643)	4.23316821
22	proline transport (GO:0015824)	4.20086730
23	leukotriene metabolic process (GO:0006691)	4.17733466
24	protein K6-linked ubiquitination (GO:0085020)	4.14899639
25	alanine transport (GO:0032328)	4.12569863
26	maturation of 5.8S rRNA (GO:0000460)	4.08521896
27	positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)	4.02248865
28	regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)	4.02248865
29	fatty acid derivative biosynthetic process (GO:1901570)	3.99582389
30	icosanoid biosynthetic process (GO:0046456)	3.99582389
31	methionine biosynthetic process (GO:0009086)	3.91253648
32	regulation of immunoglobulin secretion (GO:0051023)	3.88718583
33	negative regulation of viral transcription (GO:0032897)	3.83488359
34	protein neddylation (GO:0045116)	3.77528691
35	peptide biosynthetic process (GO:0043043)	3.73946965
36	positive regulation of heterotypic cell-cell adhesion (GO:0034116)	3.72001657
37	peptidyl-arginine omega-N-methylation (GO:0035247)	3.63845132
38	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.59358985
39	regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003339	3.57184627
40	chaperone-mediated protein transport (GO:0072321)	3.54981089
41	regulation of MHC class II biosynthetic process (GO:0045346)	3.52528476
42	negative regulation of alpha-beta T cell differentiation (GO:0046639)	3.42011137
43	mitochondrial RNA metabolic process (GO:0000959)	3.40147778
44	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	3.38026488
45	negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)	3.33116418
46	glutathione metabolic process (GO:0006749)	3.32613710
47	sulfur amino acid biosynthetic process (GO:0000097)	3.27254852
48	histone arginine methylation (GO:0034969)	3.24313493
49	unsaturated fatty acid biosynthetic process (GO:0006636)	3.22921114
50	water-soluble vitamin biosynthetic process (GO:0042364)	3.19599193
51	methionine metabolic process (GO:0006555)	3.18857922
52	glycine transport (GO:0015816)	3.12608883
53	regulation of cellular amino acid metabolic process (GO:0006521)	3.07989770
54	T cell differentiation involved in immune response (GO:0002292)	3.07730358
55	alpha-beta T cell differentiation involved in immune response (GO:0002293)	3.07730358
56	alpha-beta T cell activation involved in immune response (GO:0002287)	3.07730358
57	phosphatidylethanolamine metabolic process (GO:0046337)	3.06913171
58	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.05691321
59	CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)	3.04888292
60	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.00083869
61	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.99176677
62	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.97363242
63	positive regulation of chemokine biosynthetic process (GO:0045080)	2.96239138
64	peptidyl-arginine methylation (GO:0018216)	2.92822353
65	peptidyl-arginine N-methylation (GO:0035246)	2.92822353
66	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.91125680
67	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.90860592
68	negative regulation of ligase activity (GO:0051352)	2.90860592
69	DNA replication checkpoint (GO:0000076)	2.90435208
70	aspartate family amino acid biosynthetic process (GO:0009067)	2.87439965
71	positive regulation of isotype switching (GO:0045830)	2.87103369
72	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.84674589
73	positive regulation of granulocyte differentiation (GO:0030854)	2.78876548
74	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.78474630
75	mitochondrial respiratory chain complex assembly (GO:0033108)	2.77497710
76	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.75200007
77	glutathione derivative metabolic process (GO:1901685)	2.74269784
78	glutathione derivative biosynthetic process (GO:1901687)	2.74269784
79	dopamine transport (GO:0015872)	2.73977119
80	piRNA metabolic process (GO:0034587)	2.71823844
81	intracellular protein transmembrane import (GO:0044743)	2.68987462
82	defense response to protozoan (GO:0042832)	2.67877147
83	estrogen biosynthetic process (GO:0006703)	2.67390110
84	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.66257854
85	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.63643121
86	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.63643121
87	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.63643121
88	positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)	2.62636142
89	neurotransmitter uptake (GO:0001504)	2.61565977
90	kinetochore assembly (GO:0051382)	2.61440348
91	negative regulation of interleukin-2 production (GO:0032703)	2.60548308
92	positive regulation of DNA recombination (GO:0045911)	2.60500600
93	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.58940507
94	artery development (GO:0060840)	2.58933840
95	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.57721920
96	negative regulation of neurological system process (GO:0031645)	2.57692731
97	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.57414032
98	cullin deneddylation (GO:0010388)	2.56966171
99	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.56904114
100	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.56904114

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GATA1_22025678_ChIP-Seq_K562_Human	5.16407670
2	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.42577015
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.41257768
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.36541896
5	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.29526870
6	BP1_19119308_ChIP-ChIP_Hs578T_Human	3.10975690
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.90304097
8	VDR_22108803_ChIP-Seq_LS180_Human	2.87555018
9	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.78757650
10	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.78586352
11	ZNF274_21170338_ChIP-Seq_K562_Hela	2.63438404
12	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.59117757
13	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.52768379
14	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.50874032
15	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.32639027
16	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.29753085
17	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.26189949
18	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.24579257
19	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.13571749
20	VDR_23849224_ChIP-Seq_CD4+_Human	2.03726015
21	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	2.01741291
22	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.93061008
23	ELK1_19687146_ChIP-ChIP_HELA_Human	1.91791030
24	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.84146767
25	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.81002938
26	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.79093984
27	EWS_26573619_Chip-Seq_HEK293_Human	1.75325242
28	ER_23166858_ChIP-Seq_MCF-7_Human	1.71204181
29	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.69900731
30	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.67425648
31	FUS_26573619_Chip-Seq_HEK293_Human	1.66302994
32	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.66131130
33	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.66048160
34	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.63750580
35	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.62041906
36	IGF1R_20145208_ChIP-Seq_DFB_Human	1.61025390
37	GBX2_23144817_ChIP-Seq_PC3_Human	1.52556788
38	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.50388840
39	TAF15_26573619_Chip-Seq_HEK293_Human	1.47496939
40	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.45550744
41	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.45367375
42	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.44627578
43	FOXP3_21729870_ChIP-Seq_TREG_Human	1.43523573
44	P300_19829295_ChIP-Seq_ESCs_Human	1.42679396
45	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.41423823
46	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.40825881
47	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.40633176
48	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.39630660
49	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.39544992
50	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.38905586
51	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.38323389
52	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.34946358
53	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.30542354
54	BCAT_22108803_ChIP-Seq_LS180_Human	1.30100941
55	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.29891761
56	MYC_18940864_ChIP-ChIP_HL60_Human	1.29729040
57	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.29057680
58	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.28354195
59	AR_21572438_ChIP-Seq_LNCaP_Human	1.26770395
60	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.25513768
61	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.22824320
62	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.20854969
63	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.19519276
64	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.18623988
65	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.17529589
66	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.17529589
67	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.16955105
68	CBP_20019798_ChIP-Seq_JUKART_Human	1.16955105
69	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.16342816
70	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.10463443
71	TP53_22573176_ChIP-Seq_HFKS_Human	1.06727015
72	TCF4_23295773_ChIP-Seq_U87_Human	1.05889167
73	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.05369152
74	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.04839095
75	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.04722405
76	SOX2_19829295_ChIP-Seq_ESCs_Human	1.03708788
77	NANOG_19829295_ChIP-Seq_ESCs_Human	1.03708788
78	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.03638417
79	TCF4_22108803_ChIP-Seq_LS180_Human	1.00772704
80	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.00561997
81	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.98722130
82	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.98637195
83	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.97872866
84	SALL4_22934838_ChIP-ChIP_CD34+_Human	0.95880842
85	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.95164431
86	MYC_18555785_ChIP-Seq_MESCs_Mouse	0.94888234
87	NCOR_22424771_ChIP-Seq_293T_Human	0.93830470
88	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.93611843
89	HOXB7_26014856_ChIP-Seq_BT474_Human	0.92395698
90	MYB_26560356_Chip-Seq_TH2_Human	0.91810250
91	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.91752036
92	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.90579902
93	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.90104554
94	GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse	0.90049881
95	SMAD4_21799915_ChIP-Seq_A2780_Human	0.88737081
96	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.88061166
97	ELF5_23300383_ChIP-Seq_T47D_Human	0.87828005
98	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.87683917
99	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.87220197
100	ERG_20517297_ChIP-Seq_VCAP_Human	0.86537146

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003195_calcinosis	5.27152286
2	MP0003011_delayed_dark_adaptation	3.97043010
3	MP0001873_stomach_inflammation	3.85399105
4	MP0008995_early_reproductive_senescence	3.61170912
5	MP0005671_abnormal_response_to	3.11590027
6	MP0006082_CNS_inflammation	2.54200908
7	MP0001348_abnormal_lacrimal_gland	2.46122445
8	MP0003786_premature_aging	2.43292929
9	MP0001835_abnormal_antigen_presentation	2.36860708
10	MP0003880_abnormal_central_pattern	2.35745655
11	MP0005645_abnormal_hypothalamus_physiol	2.30946943
12	MP0003806_abnormal_nucleotide_metabolis	2.25229280
13	MP0002736_abnormal_nociception_after	2.17782814
14	MP0002876_abnormal_thyroid_physiology	2.16529732
15	MP0008872_abnormal_physiological_respon	2.16019155
16	MP0004147_increased_porphyrin_level	2.01435368
17	MP0009785_altered_susceptibility_to	1.95293470
18	MP0010094_abnormal_chromosome_stability	1.91366860
19	MP0002163_abnormal_gland_morphology	1.79377092
20	MP0000569_abnormal_digit_pigmentation	1.76117802
21	MP0002148_abnormal_hypersensitivity_rea	1.74345671
22	MP0008875_abnormal_xenobiotic_pharmacok	1.73064973
23	MP0002102_abnormal_ear_morphology	1.70906448
24	MP0006035_abnormal_mitochondrial_morpho	1.70482641
25	MP0001529_abnormal_vocalization	1.58891347
26	MP0002234_abnormal_pharynx_morphology	1.58229381
27	MP0006036_abnormal_mitochondrial_physio	1.57008016
28	MP0001968_abnormal_touch/_nociception	1.54630362
29	MP0003646_muscle_fatigue	1.54173061
30	MP0005310_abnormal_salivary_gland	1.50580206
31	MP0005646_abnormal_pituitary_gland	1.48839765
32	MP0008877_abnormal_DNA_methylation	1.35529667
33	MP0003693_abnormal_embryo_hatching	1.31320974
34	MP0006276_abnormal_autonomic_nervous	1.28903837
35	MP0005387_immune_system_phenotype	1.28000724
36	MP0001790_abnormal_immune_system	1.28000724
37	MP0001905_abnormal_dopamine_level	1.27494660
38	MP0003567_abnormal_fetal_cardiomyocyte	1.25176331
39	MP0004142_abnormal_muscle_tone	1.24491096
40	MP0002751_abnormal_autonomic_nervous	1.24431651
41	MP0002277_abnormal_respiratory_mucosa	1.23832298
42	MP0009333_abnormal_splenocyte_physiolog	1.22900562
43	MP0010307_abnormal_tumor_latency	1.22794118
44	MP0000613_abnormal_salivary_gland	1.18989544
45	MP0003045_fibrosis	1.16997798
46	MP0001293_anophthalmia	1.16751654
47	MP0000372_irregular_coat_pigmentation	1.15283770
48	MP0005332_abnormal_amino_acid	1.15246805
49	MP0005551_abnormal_eye_electrophysiolog	1.14693740
50	MP0008789_abnormal_olfactory_epithelium	1.14299680
51	MP0009697_abnormal_copulation	1.12495542
52	MP0001501_abnormal_sleep_pattern	1.09627433
53	MP0004742_abnormal_vestibular_system	1.07098069
54	MP0005000_abnormal_immune_tolerance	1.06552112
55	MP0003763_abnormal_thymus_physiology	1.05130923
56	MP0000631_abnormal_neuroendocrine_gland	1.03408633
57	MP0006072_abnormal_retinal_apoptosis	1.03150629
58	MP0003718_maternal_effect	1.02562215
59	MP0001800_abnormal_humoral_immune	1.02081632
60	MP0000685_abnormal_immune_system	0.99241072
61	MP0005647_abnormal_sex_gland	0.97875953
62	MP0002653_abnormal_ependyma_morphology	0.97641874
63	MP0005253_abnormal_eye_physiology	0.96915303
64	MP0001984_abnormal_olfaction	0.96024188
65	MP0008058_abnormal_DNA_repair	0.94021251
66	MP0001119_abnormal_female_reproductive	0.90789795
67	MP0004133_heterotaxia	0.86023520
68	MP0005379_endocrine/exocrine_gland_phen	0.82663903
69	MP0001958_emphysema	0.81686090
70	MP0001919_abnormal_reproductive_system	0.79478741
71	MP0000427_abnormal_hair_cycle	0.79019211
72	MP0003943_abnormal_hepatobiliary_system	0.75981173
73	MP0003878_abnormal_ear_physiology	0.75502704
74	MP0005377_hearing/vestibular/ear_phenot	0.75502704
75	MP0003137_abnormal_impulse_conducting	0.75338201
76	MP0002229_neurodegeneration	0.75247331
77	MP0002272_abnormal_nervous_system	0.74684834
78	MP0002210_abnormal_sex_determination	0.74376267
79	MP0004270_analgesia	0.72046507
80	MP0003936_abnormal_reproductive_system	0.71315561
81	MP0003937_abnormal_limbs/digits/tail_de	0.70810832
82	MP0003186_abnormal_redox_activity	0.68935715
83	MP0002089_abnormal_postnatal_growth/wei	0.68693577
84	MP0001502_abnormal_circadian_rhythm	0.68462424
85	MP0004957_abnormal_blastocyst_morpholog	0.68337317
86	MP0002405_respiratory_system_inflammati	0.67809083
87	MP0004084_abnormal_cardiac_muscle	0.67217256
88	MP0005395_other_phenotype	0.66590535
89	MP0001881_abnormal_mammary_gland	0.66524206
90	MP0002723_abnormal_immune_serum	0.65848032
91	MP0005075_abnormal_melanosome_morpholog	0.65845688
92	MP0003436_decreased_susceptibility_to	0.64576600
93	MP0002420_abnormal_adaptive_immunity	0.63757149
94	MP0004145_abnormal_muscle_electrophysio	0.63082842
95	MP0005584_abnormal_enzyme/coenzyme_acti	0.62431983
96	MP0002693_abnormal_pancreas_physiology	0.60901152
97	MP0003959_abnormal_lean_body	0.60661351
98	MP0000689_abnormal_spleen_morphology	0.60409388
99	MP0001819_abnormal_immune_cell	0.60318788
100	MP0002006_tumorigenesis	0.60087010

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.58630603
2	Homocystinuria (HP:0002156)	4.16229972
3	Abnormality of homocysteine metabolism (HP:0010919)	4.16229972
4	Acute encephalopathy (HP:0006846)	3.80594542
5	Stomatitis (HP:0010280)	3.74581886
6	Progressive macrocephaly (HP:0004481)	3.70350073
7	Abnormal mitochondria in muscle tissue (HP:0008316)	3.69298440
8	Abnormality of methionine metabolism (HP:0010901)	3.44795693
9	Gonadotropin excess (HP:0000837)	3.35027087
10	Central scotoma (HP:0000603)	3.30067393
11	Pendular nystagmus (HP:0012043)	3.29906562
12	Abnormal delayed hypersensitivity skin test (HP:0002963)	3.23045047
13	Mitochondrial inheritance (HP:0001427)	3.17327874
14	True hermaphroditism (HP:0010459)	3.11116747
15	Panhypogammaglobulinemia (HP:0003139)	3.06304358
16	Abnormality of macular pigmentation (HP:0008002)	3.05087989
17	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.96118693
18	Type 2 muscle fiber atrophy (HP:0003554)	2.93025561
19	Molar tooth sign on MRI (HP:0002419)	2.91248170
20	Abnormality of midbrain morphology (HP:0002418)	2.91248170
21	Cerebral edema (HP:0002181)	2.85656720
22	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.85198110
23	Increased CSF lactate (HP:0002490)	2.83852032
24	Abnormality of vitamin B metabolism (HP:0004340)	2.78515394
25	Carpal bone hypoplasia (HP:0001498)	2.75219989
26	Absent/shortened dynein arms (HP:0200106)	2.69907286
27	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.69907286
28	Pancreatic cysts (HP:0001737)	2.63744055
29	Abnormality of the labia minora (HP:0012880)	2.61089681
30	Arthropathy (HP:0003040)	2.55801694
31	Supernumerary spleens (HP:0009799)	2.54621176
32	Meckel diverticulum (HP:0002245)	2.54489133
33	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.54118376
34	Optic disc pallor (HP:0000543)	2.52346187
35	Recurrent cutaneous fungal infections (HP:0011370)	2.49785473
36	Chronic mucocutaneous candidiasis (HP:0002728)	2.49785473
37	IgG deficiency (HP:0004315)	2.48517511
38	Pancreatic fibrosis (HP:0100732)	2.46790886
39	Abnormality of the ileum (HP:0001549)	2.45205440
40	Nephronophthisis (HP:0000090)	2.43978690
41	Muscle fiber atrophy (HP:0100295)	2.42347928
42	Abnormality of sulfur amino acid metabolism (HP:0004339)	2.38914618
43	Attenuation of retinal blood vessels (HP:0007843)	2.35914528
44	Pheochromocytoma (HP:0002666)	2.35595142
45	Episodic fever (HP:0001954)	2.34940419
46	Scotoma (HP:0000575)	2.34450537
47	Renal Fanconi syndrome (HP:0001994)	2.33271026
48	Palpebral edema (HP:0100540)	2.29983115
49	Increased hepatocellular lipid droplets (HP:0006565)	2.27544219
50	Abnormality of the fovea (HP:0000493)	2.26459638
51	Megaloblastic anemia (HP:0001889)	2.24261712
52	Decreased central vision (HP:0007663)	2.21691593
53	Abnormal number of incisors (HP:0011064)	2.19789585
54	Glioma (HP:0009733)	2.18809873
55	Neuroendocrine neoplasm (HP:0100634)	2.17946976
56	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.15410665
57	Hypoplasia of the pons (HP:0012110)	2.12974995
58	Midline defect of the nose (HP:0004122)	2.12856655
59	Anencephaly (HP:0002323)	2.11508203
60	Nausea (HP:0002018)	2.10188696
61	Submucous cleft hard palate (HP:0000176)	2.08783970
62	Lipid accumulation in hepatocytes (HP:0006561)	2.07265723
63	Hypoproteinemia (HP:0003075)	2.06928893
64	Keratoconus (HP:0000563)	2.05883198
65	Increased corneal curvature (HP:0100692)	2.05883198
66	Abnormality of serum amino acid levels (HP:0003112)	1.98295843
67	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	1.98282358
68	Diastasis recti (HP:0001540)	1.96876292
69	Brushfield spots (HP:0001088)	1.96756345
70	Abnormality of T cell number (HP:0011839)	1.96581246
71	Abnormal rod and cone electroretinograms (HP:0008323)	1.95099883
72	Abolished electroretinogram (ERG) (HP:0000550)	1.94690713
73	Autoimmune hemolytic anemia (HP:0001890)	1.94558808
74	Abnormal respiratory epithelium morphology (HP:0012253)	1.93474898
75	Abnormal respiratory motile cilium morphology (HP:0005938)	1.93474898
76	Severe global developmental delay (HP:0011344)	1.93293603
77	Abnormality of the pons (HP:0007361)	1.92092699
78	T lymphocytopenia (HP:0005403)	1.91399477
79	Methylmalonic acidemia (HP:0002912)	1.90161350
80	Leukodystrophy (HP:0002415)	1.89819890
81	Chronic hepatic failure (HP:0100626)	1.88423353
82	Type I transferrin isoform profile (HP:0003642)	1.88383010
83	Pustule (HP:0200039)	1.87231936
84	Exertional dyspnea (HP:0002875)	1.85381110
85	Paralysis (HP:0003470)	1.85004053
86	Severe visual impairment (HP:0001141)	1.83906566
87	Gonadal dysgenesis (HP:0000133)	1.83839814
88	Hypomagnesemia (HP:0002917)	1.83811317
89	Abnormality of T cell physiology (HP:0011840)	1.83457932
90	Abnormality of T cells (HP:0002843)	1.83173134
91	Hepatocellular necrosis (HP:0001404)	1.82606272
92	Broad alveolar ridges (HP:0000187)	1.81960488
93	Abnormality of the renal medulla (HP:0100957)	1.81848791
94	Male pseudohermaphroditism (HP:0000037)	1.81665335
95	Abnormal ciliary motility (HP:0012262)	1.79873367
96	Inability to walk (HP:0002540)	1.79820773
97	Lethargy (HP:0001254)	1.79500841
98	Meningioma (HP:0002858)	1.78647078
99	Thyroiditis (HP:0100646)	1.77314202
100	Abnormality of the astrocytes (HP:0100707)	1.76756052

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TSSK6	5.06551758
2	PBK	4.70756727
3	MAP4K2	4.67210870
4	BUB1	3.41870721
5	EPHA3	3.05959080
6	MST4	3.04071088
7	PINK1	2.86557078
8	EIF2AK1	2.77219769
9	TXK	2.49567747
10	SRPK1	2.31603227
11	ZAK	2.27481202
12	EIF2AK3	2.14832834
13	NME1	1.97220791
14	VRK2	1.90538538
15	TLK1	1.89444158
16	WNK3	1.87709393
17	STK39	1.86616758
18	ADRBK2	1.80209475
19	WNK4	1.79178916
20	BMPR1B	1.71785579
21	OXSR1	1.70062098
22	NEK1	1.63349213
23	NTRK3	1.52074573
24	PLK3	1.37674165
25	TEC	1.23315364
26	FRK	1.22697471
27	TNIK	1.22613726
28	CASK	1.22443998
29	MATK	1.18729848
30	BRD4	1.17203401
31	MAPK13	1.12443887
32	TTK	1.00156208
33	MAP2K6	0.97735811
34	ALK	0.97132049
35	PIK3CG	0.93699214
36	EIF2AK2	0.92239336
37	MKNK1	0.88535408
38	NTRK1	0.86034333
39	VRK1	0.82488472
40	CAMKK2	0.78662587
41	TAF1	0.78355003
42	BRSK2	0.75885480
43	JAK3	0.75647654
44	TAOK3	0.75392133
45	GRK1	0.72470749
46	BCKDK	0.71444273
47	NUAK1	0.70552416
48	NLK	0.69682550
49	PRKG2	0.69257844
50	CDK3	0.68131790
51	EPHA4	0.63408853
52	ATR	0.61515732
53	KDR	0.61021184
54	IKBKB	0.60889984
55	ACVR1B	0.58159883
56	CDC7	0.56392115
57	LCK	0.56288389
58	ADRBK1	0.52704758
59	BCR	0.51994519
60	MINK1	0.51325709
61	MAP3K12	0.50791914
62	WEE1	0.50503730
63	DYRK2	0.50398516
64	PLK1	0.48098700
65	IGF1R	0.47242483
66	MAP3K4	0.45808135
67	MAP3K5	0.45095991
68	FGFR1	0.45002100
69	MAPKAPK5	0.44987225
70	MKNK2	0.44374472
71	GRK7	0.43917687
72	ITK	0.43596445
73	EPHB2	0.42168841
74	WNK1	0.42068794
75	TRIM28	0.40796460
76	MAP4K1	0.39689981
77	SYK	0.39558718
78	ATM	0.39036054
79	OBSCN	0.38248270
80	BMPR2	0.37753401
81	TIE1	0.37050164
82	PLK2	0.36278952
83	PRKCQ	0.35500818
84	CDK8	0.34953500
85	TYK2	0.34499523
86	AURKB	0.32033798
87	CDK9	0.31921779
88	INSRR	0.30828189
89	STK4	0.28051483
90	YES1	0.27592068
91	NEK2	0.26497388
92	RPS6KB2	0.25624942
93	CSNK1A1	0.25176413
94	IRAK1	0.23603415
95	PIK3CA	0.22600130
96	PHKG1	0.19403136
97	PHKG2	0.19403136
98	CAMK2A	0.18864008
99	CSNK2A2	0.18780872
100	CSNK1E	0.18544689

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	4.67561155
2	Cyanoamino acid metabolism_Homo sapiens_hsa00460	3.11303791
3	Selenocompound metabolism_Homo sapiens_hsa00450	3.04670462
4	One carbon pool by folate_Homo sapiens_hsa00670	2.99323349
5	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.96023045
6	Allograft rejection_Homo sapiens_hsa05330	2.71813301
7	Primary immunodeficiency_Homo sapiens_hsa05340	2.58281094
8	Oxidative phosphorylation_Homo sapiens_hsa00190	2.46613485
9	RNA polymerase_Homo sapiens_hsa03020	2.36768737
10	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.23213148
11	Asthma_Homo sapiens_hsa05310	2.16359948
12	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.15223512
13	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.10901336
14	Parkinsons disease_Homo sapiens_hsa05012	2.08620147
15	Homologous recombination_Homo sapiens_hsa03440	1.93690395
16	Fanconi anemia pathway_Homo sapiens_hsa03460	1.88734367
17	Protein export_Homo sapiens_hsa03060	1.77287372
18	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.66843405
19	Graft-versus-host disease_Homo sapiens_hsa05332	1.57266610
20	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.55439041
21	Caffeine metabolism_Homo sapiens_hsa00232	1.54121709
22	Type I diabetes mellitus_Homo sapiens_hsa04940	1.53119412
23	Huntingtons disease_Homo sapiens_hsa05016	1.45067623
24	Basal transcription factors_Homo sapiens_hsa03022	1.42805573
25	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.40574462
26	Mismatch repair_Homo sapiens_hsa03430	1.39807078
27	RNA degradation_Homo sapiens_hsa03018	1.37047031
28	Non-homologous end-joining_Homo sapiens_hsa03450	1.35929216
29	Linoleic acid metabolism_Homo sapiens_hsa00591	1.32801481
30	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.30963944
31	Nucleotide excision repair_Homo sapiens_hsa03420	1.29937459
32	Antigen processing and presentation_Homo sapiens_hsa04612	1.25418418
33	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.19151268
34	Propanoate metabolism_Homo sapiens_hsa00640	1.15610628
35	Alzheimers disease_Homo sapiens_hsa05010	1.14501438
36	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.13276799
37	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.09602993
38	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.08633491
39	Nitrogen metabolism_Homo sapiens_hsa00910	1.07810796
40	DNA replication_Homo sapiens_hsa03030	1.05352836
41	Phototransduction_Homo sapiens_hsa04744	1.05153149
42	Pyrimidine metabolism_Homo sapiens_hsa00240	1.04987299
43	Rheumatoid arthritis_Homo sapiens_hsa05323	1.01727611
44	Ribosome_Homo sapiens_hsa03010	0.99928046
45	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.98399895
46	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.97346932
47	Butanoate metabolism_Homo sapiens_hsa00650	0.96291627
48	beta-Alanine metabolism_Homo sapiens_hsa00410	0.93085163
49	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.90700965
50	Purine metabolism_Homo sapiens_hsa00230	0.86932048
51	RNA transport_Homo sapiens_hsa03013	0.85235910
52	Folate biosynthesis_Homo sapiens_hsa00790	0.83864424
53	Measles_Homo sapiens_hsa05162	0.81244571
54	Spliceosome_Homo sapiens_hsa03040	0.80977783
55	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.79687892
56	Nicotine addiction_Homo sapiens_hsa05033	0.78861786
57	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.74349867
58	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.72893690
59	Peroxisome_Homo sapiens_hsa04146	0.71980678
60	Retinol metabolism_Homo sapiens_hsa00830	0.71379852
61	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.71333527
62	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.67842962
63	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.67792320
64	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.64008732
65	Olfactory transduction_Homo sapiens_hsa04740	0.58957919
66	Regulation of autophagy_Homo sapiens_hsa04140	0.57878532
67	Base excision repair_Homo sapiens_hsa03410	0.57170589
68	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.56462582
69	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.55191754
70	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.54727453
71	Ether lipid metabolism_Homo sapiens_hsa00565	0.53600911
72	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.53548875
73	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.51934517
74	Glutathione metabolism_Homo sapiens_hsa00480	0.50596068
75	Collecting duct acid secretion_Homo sapiens_hsa04966	0.50433225
76	GABAergic synapse_Homo sapiens_hsa04727	0.49606557
77	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.49236306
78	Morphine addiction_Homo sapiens_hsa05032	0.48580915
79	Malaria_Homo sapiens_hsa05144	0.47525110
80	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.45738538
81	Metabolic pathways_Homo sapiens_hsa01100	0.42719735
82	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.42219310
83	African trypanosomiasis_Homo sapiens_hsa05143	0.41753504
84	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.39663526
85	mRNA surveillance pathway_Homo sapiens_hsa03015	0.39150071
86	Tryptophan metabolism_Homo sapiens_hsa00380	0.38383712
87	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.36056721
88	Chemical carcinogenesis_Homo sapiens_hsa05204	0.34055279
89	Pyruvate metabolism_Homo sapiens_hsa00620	0.31918812
90	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.30783864
91	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.28824162
92	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.28000041
93	Cardiac muscle contraction_Homo sapiens_hsa04260	0.27100034
94	Glycerolipid metabolism_Homo sapiens_hsa00561	0.25497097
95	p53 signaling pathway_Homo sapiens_hsa04115	0.25496888
96	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.25149854
97	Cell cycle_Homo sapiens_hsa04110	0.24334691
98	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.23559654
99	Herpes simplex infection_Homo sapiens_hsa05168	0.22707719
100	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.21381902

DCAF13P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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