ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	sequestering of actin monomers (GO:0042989)	5.75709966
2	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	5.71746265
3	cytoplasmic mRNA processing body assembly (GO:0033962)	5.05531737
4	neural tube formation (GO:0001841)	4.72089282
5	pyrimidine nucleobase catabolic process (GO:0006208)	4.34435946
6	urogenital system development (GO:0001655)	4.34324106
7	negative regulation of synaptic transmission, GABAergic (GO:0032229)	4.34036468
8	positive regulation of amino acid transport (GO:0051957)	4.33775453
9	somite development (GO:0061053)	4.15707252
10	centriole replication (GO:0007099)	4.03983797
11	proteasome assembly (GO:0043248)	4.02553230
12	spinal cord motor neuron differentiation (GO:0021522)	3.95678397
13	otic vesicle formation (GO:0030916)	3.87308352
14	opioid receptor signaling pathway (GO:0038003)	3.78088101
15	regulation of glutamate secretion (GO:0014048)	3.73311089
16	L-fucose catabolic process (GO:0042355)	3.71583964
17	fucose catabolic process (GO:0019317)	3.71583964
18	L-fucose metabolic process (GO:0042354)	3.71583964
19	centriole assembly (GO:0098534)	3.69071219
20	negative regulation of telomere maintenance (GO:0032205)	3.64043994
21	behavioral response to nicotine (GO:0035095)	3.60447692
22	epithelial cilium movement (GO:0003351)	3.57651823
23	cilium or flagellum-dependent cell motility (GO:0001539)	3.56461684
24	G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)	3.54732670
25	nucleobase catabolic process (GO:0046113)	3.50241050
26	negative regulation of axon guidance (GO:1902668)	3.41929305
27	dopaminergic neuron differentiation (GO:0071542)	3.38876824
28	adaptation of signaling pathway (GO:0023058)	3.38866589
29	lateral sprouting from an epithelium (GO:0060601)	3.36489321
30	prenylation (GO:0097354)	3.33503778
31	protein prenylation (GO:0018342)	3.33503778
32	limb development (GO:0060173)	3.32787593
33	appendage development (GO:0048736)	3.32787593
34	axonemal dynein complex assembly (GO:0070286)	3.32626362
35	regulation of amino acid transport (GO:0051955)	3.31192031
36	photoreceptor cell differentiation (GO:0046530)	3.30792217
37	eye photoreceptor cell differentiation (GO:0001754)	3.30792217
38	serine family amino acid catabolic process (GO:0009071)	3.29311221
39	midbrain development (GO:0030901)	3.27986336
40	cranial nerve development (GO:0021545)	3.27829154
41	limb bud formation (GO:0060174)	3.22718822
42	regulation of chromatin binding (GO:0035561)	3.21410089
43	artery development (GO:0060840)	3.21367717
44	heart valve formation (GO:0003188)	3.19353824
45	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.18841328
46	presynaptic membrane assembly (GO:0097105)	3.12481020
47	cysteine metabolic process (GO:0006534)	3.12200279
48	histone mRNA catabolic process (GO:0071044)	3.11215961
49	polyketide metabolic process (GO:0030638)	3.10886755
50	doxorubicin metabolic process (GO:0044598)	3.10886755
51	daunorubicin metabolic process (GO:0044597)	3.10886755
52	endocardial cushion morphogenesis (GO:0003203)	3.07004313
53	microtubule nucleation (GO:0007020)	3.06082195
54	DNA double-strand break processing (GO:0000729)	3.05761603
55	nonmotile primary cilium assembly (GO:0035058)	3.05378130
56	behavioral response to ethanol (GO:0048149)	3.01459316
57	regulation of cilium movement (GO:0003352)	3.01150589
58	negative regulation of amino acid transport (GO:0051956)	3.00620902
59	regulation of translational fidelity (GO:0006450)	3.00174383
60	cullin deneddylation (GO:0010388)	2.97886744
61	protein-cofactor linkage (GO:0018065)	2.97595126
62	nodal signaling pathway (GO:0038092)	2.96866228
63	presynaptic membrane organization (GO:0097090)	2.96750047
64	embryonic epithelial tube formation (GO:0001838)	2.96637387
65	neuron fate determination (GO:0048664)	2.95790925
66	negative regulation of interleukin-1 beta production (GO:0032691)	2.95727292
67	central nervous system myelination (GO:0022010)	2.94716721
68	axon ensheathment in central nervous system (GO:0032291)	2.94716721
69	regulation of cell proliferation involved in heart morphogenesis (GO:2000136)	2.90721607
70	DNA catabolic process, exonucleolytic (GO:0000738)	2.90664817
71	cilium morphogenesis (GO:0060271)	2.88641606
72	motile cilium assembly (GO:0044458)	2.86143294
73	cilium movement (GO:0003341)	2.85471769
74	chaperone-mediated protein transport (GO:0072321)	2.83646915
75	regulation of chemokine-mediated signaling pathway (GO:0070099)	2.80397112
76	mesenchyme morphogenesis (GO:0072132)	2.80246257
77	inner ear receptor stereocilium organization (GO:0060122)	2.79731572
78	positive regulation of microtubule polymerization (GO:0031116)	2.79599542
79	activin receptor signaling pathway (GO:0032924)	2.78673674
80	epithelial tube formation (GO:0072175)	2.78207803
81	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.77918464
82	aminoglycoside antibiotic metabolic process (GO:0030647)	2.76387459
83	cell differentiation in spinal cord (GO:0021515)	2.74456808
84	positive regulation of microtubule polymerization or depolymerization (GO:0031112)	2.72708244
85	gamma-aminobutyric acid transport (GO:0015812)	2.71926893
86	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.70506108
87	positive regulation of male gonad development (GO:2000020)	2.69448819
88	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	2.69251242
89	sympathetic nervous system development (GO:0048485)	2.68753883
90	serotonin metabolic process (GO:0042428)	2.65578235
91	retinal ganglion cell axon guidance (GO:0031290)	2.62967468
92	positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)	2.62751187
93	smoothened signaling pathway (GO:0007224)	2.62414881
94	pharyngeal system development (GO:0060037)	2.61298681
95	startle response (GO:0001964)	2.60710986
96	histone H4-K12 acetylation (GO:0043983)	2.60697358
97	type B pancreatic cell proliferation (GO:0044342)	2.60637706
98	regulation of axon guidance (GO:1902667)	2.58878994
99	cellular response to sterol (GO:0036315)	2.58407917
100	neuronal action potential (GO:0019228)	2.57838272

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	RBPJ_22232070_ChIP-Seq_NCS_Mouse	3.59478445
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.25946692
3	EZH2_22144423_ChIP-Seq_EOC_Human	3.25881044
4	AR_21572438_ChIP-Seq_LNCaP_Human	2.85887623
5	TAF15_26573619_Chip-Seq_HEK293_Human	2.75525819
6	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.74244708
7	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.47347230
8	VDR_22108803_ChIP-Seq_LS180_Human	2.35168454
9	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.33752789
10	FUS_26573619_Chip-Seq_HEK293_Human	2.29758881
11	P300_19829295_ChIP-Seq_ESCs_Human	2.26161556
12	PIAS1_25552417_ChIP-Seq_VCAP_Human	2.17347298
13	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.14926322
14	GBX2_23144817_ChIP-Seq_PC3_Human	2.13484931
15	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.12697417
16	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.09258482
17	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.06885896
18	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.04371292
19	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.01571437
20	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.91425734
21	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.87966245
22	AR_25329375_ChIP-Seq_VCAP_Human	1.85232285
23	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.77311758
24	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.75966968
25	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.69837416
26	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.69812040
27	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.66131544
28	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.66131544
29	EWS_26573619_Chip-Seq_HEK293_Human	1.63657612
30	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.61392179
31	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.61306138
32	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.59774445
33	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.52998512
34	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.52788224
35	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.52369139
36	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.51181462
37	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.50482821
38	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.49623446
39	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.47677338
40	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.47408725
41	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.46666111
42	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.43755874
43	CBP_20019798_ChIP-Seq_JUKART_Human	1.43371145
44	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.43371145
45	RUNX2_22187159_ChIP-Seq_PCA_Human	1.41897525
46	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.41205652
47	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.39867087
48	BCAT_22108803_ChIP-Seq_LS180_Human	1.37509733
49	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.35547644
50	ER_23166858_ChIP-Seq_MCF-7_Human	1.34497350
51	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.34267820
52	REST_21632747_ChIP-Seq_MESCs_Mouse	1.33856613
53	MYC_18940864_ChIP-ChIP_HL60_Human	1.33454122
54	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.32508686
55	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.31603500
56	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.31324028
57	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.30930724
58	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.29601459
59	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.28592107
60	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.27762979
61	SMAD4_21799915_ChIP-Seq_A2780_Human	1.27382190
62	RNF2_27304074_Chip-Seq_NSC_Mouse	1.24993478
63	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.24455927
64	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.24455927
65	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.22652195
66	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.22313483
67	AR_20517297_ChIP-Seq_VCAP_Human	1.22062631
68	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.20572800
69	NCOR_22424771_ChIP-Seq_293T_Human	1.20394871
70	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.19588907
71	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.17249384
72	TCF4_22108803_ChIP-Seq_LS180_Human	1.16671626
73	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.16467220
74	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.16124726
75	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.15897079
76	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.14322999
77	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.14262001
78	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.12449333
79	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.11407014
80	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.10789543
81	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.10745581
82	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.09998266
83	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.09216860
84	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.09153006
85	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.08905783
86	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.08794542
87	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.08704099
88	IGF1R_20145208_ChIP-Seq_DFB_Human	1.08602734
89	ELK1_19687146_ChIP-ChIP_HELA_Human	1.08383148
90	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.08365150
91	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.08115943
92	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.06942913
93	TBX3_20139965_ChIP-Seq_ESCs_Mouse	1.06447204
94	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.06306619
95	TCF4_23295773_ChIP-Seq_U87_Human	1.05725887
96	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.05603562
97	TBX3_20139965_ChIP-Seq_MESCs_Mouse	1.05577568
98	SOX2_19829295_ChIP-Seq_ESCs_Human	1.05418166
99	NANOG_19829295_ChIP-Seq_ESCs_Human	1.05418166
100	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.04552233

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002822_catalepsy	6.37445730
2	MP0003136_yellow_coat_color	4.99890270
3	MP0001529_abnormal_vocalization	3.64894384
4	MP0005171_absent_coat_pigmentation	3.12741709
5	MP0005085_abnormal_gallbladder_physiolo	3.05054792
6	MP0003890_abnormal_embryonic-extraembry	2.94986918
7	MP0006292_abnormal_olfactory_placode	2.65996934
8	MP0002837_dystrophic_cardiac_calcinosis	2.44662025
9	MP0008789_abnormal_olfactory_epithelium	2.16716325
10	MP0002938_white_spotting	2.06727897
11	MP0002928_abnormal_bile_duct	2.06256045
12	MP0000566_synostosis	2.06170719
13	MP0006072_abnormal_retinal_apoptosis	2.04867504
14	MP0004147_increased_porphyrin_level	2.03689322
15	MP0001986_abnormal_taste_sensitivity	1.99015121
16	MP0002653_abnormal_ependyma_morphology	1.98905535
17	MP0001346_abnormal_lacrimal_gland	1.93847919
18	MP0000778_abnormal_nervous_system	1.89071101
19	MP0002234_abnormal_pharynx_morphology	1.85686614
20	MP0000631_abnormal_neuroendocrine_gland	1.84653203
21	MP0005084_abnormal_gallbladder_morpholo	1.80366515
22	MP0003880_abnormal_central_pattern	1.67486870
23	MP0003011_delayed_dark_adaptation	1.62837148
24	MP0009745_abnormal_behavioral_response	1.60775528
25	MP0005647_abnormal_sex_gland	1.54543732
26	MP0004133_heterotaxia	1.54399481
27	MP0009053_abnormal_anal_canal	1.50707538
28	MP0002736_abnormal_nociception_after	1.49392667
29	MP0000579_abnormal_nail_morphology	1.45718461
30	MP0003252_abnormal_bile_duct	1.43272608
31	MP0002735_abnormal_chemical_nociception	1.41870818
32	MP0008875_abnormal_xenobiotic_pharmacok	1.40533516
33	MP0005499_abnormal_olfactory_system	1.39556052
34	MP0005394_taste/olfaction_phenotype	1.39556052
35	MP0001486_abnormal_startle_reflex	1.38417482
36	MP0009046_muscle_twitch	1.37724129
37	MP0002272_abnormal_nervous_system	1.37577727
38	MP0002282_abnormal_trachea_morphology	1.32366027
39	MP0010030_abnormal_orbit_morphology	1.31931979
40	MP0003315_abnormal_perineum_morphology	1.30350899
41	MP0001968_abnormal_touch/_nociception	1.28684441
42	MP0002751_abnormal_autonomic_nervous	1.28343768
43	MP0008058_abnormal_DNA_repair	1.26092210
44	MP0003937_abnormal_limbs/digits/tail_de	1.26026371
45	MP0002638_abnormal_pupillary_reflex	1.22761857
46	MP0001501_abnormal_sleep_pattern	1.22265575
47	MP0004142_abnormal_muscle_tone	1.21221238
48	MP0000383_abnormal_hair_follicle	1.16881866
49	MP0005408_hypopigmentation	1.13766656
50	MP0001905_abnormal_dopamine_level	1.10342375
51	MP0010386_abnormal_urinary_bladder	1.09239026
52	MP0000538_abnormal_urinary_bladder	1.09047433
53	MP0005253_abnormal_eye_physiology	1.08544431
54	MP0002067_abnormal_sensory_capabilities	1.07776177
55	MP0002138_abnormal_hepatobiliary_system	1.06045396
56	MP0001293_anophthalmia	1.05443691
57	MP0001188_hyperpigmentation	1.04392036
58	MP0002102_abnormal_ear_morphology	1.03468330
59	MP0003646_muscle_fatigue	1.03159613
60	MP0003195_calcinosis	1.02373710
61	MP0002557_abnormal_social/conspecific_i	1.02051356
62	MP0001299_abnormal_eye_distance/	1.00632848
63	MP0002277_abnormal_respiratory_mucosa	0.96885289
64	MP0002876_abnormal_thyroid_physiology	0.96633094
65	MP0002249_abnormal_larynx_morphology	0.92182924
66	MP0001324_abnormal_eye_pigmentation	0.91358306
67	MP0008872_abnormal_physiological_respon	0.90398812
68	MP0005248_abnormal_Harderian_gland	0.89890281
69	MP0000026_abnormal_inner_ear	0.89753548
70	MP0002064_seizures	0.89643999
71	MP0005332_abnormal_amino_acid	0.88726068
72	MP0002233_abnormal_nose_morphology	0.87499470
73	MP0001177_atelectasis	0.84394227
74	MP0005187_abnormal_penis_morphology	0.83908450
75	MP0001186_pigmentation_phenotype	0.81912762
76	MP0002075_abnormal_coat/hair_pigmentati	0.81796365
77	MP0005646_abnormal_pituitary_gland	0.80273268
78	MP0000427_abnormal_hair_cycle	0.79952904
79	MP0001664_abnormal_digestion	0.79320531
80	MP0002095_abnormal_skin_pigmentation	0.79050083
81	MP0005623_abnormal_meninges_morphology	0.78892788
82	MP0008877_abnormal_DNA_methylation	0.78619988
83	MP0003635_abnormal_synaptic_transmissio	0.78278484
84	MP0008995_early_reproductive_senescence	0.75591755
85	MP0000372_irregular_coat_pigmentation	0.75587118
86	MP0001970_abnormal_pain_threshold	0.74454573
87	MP0000955_abnormal_spinal_cord	0.73523502
88	MP0005391_vision/eye_phenotype	0.73170563
89	MP0002184_abnormal_innervation	0.72899207
90	MP0003123_paternal_imprinting	0.71911037
91	MP0010094_abnormal_chromosome_stability	0.69599144
92	MP0003755_abnormal_palate_morphology	0.69220652
93	MP0003959_abnormal_lean_body	0.68764035
94	MP0005551_abnormal_eye_electrophysiolog	0.68519334
95	MP0002069_abnormal_eating/drinking_beha	0.67854581
96	MP0005197_abnormal_uvea_morphology	0.67792564
97	MP0003938_abnormal_ear_development	0.67202842
98	MP0003698_abnormal_male_reproductive	0.66152683
99	MP0002063_abnormal_learning/memory/cond	0.65455635
100	MP0004924_abnormal_behavior	0.63726803

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Aplastic anemia (HP:0001915)	4.30042701
2	Chromsome breakage (HP:0040012)	4.03179993
3	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	4.01640996
4	Tubular atrophy (HP:0000092)	3.47572951
5	True hermaphroditism (HP:0010459)	3.46146811
6	Aplasia/Hypoplasia of the uvula (HP:0010293)	3.43082295
7	Genetic anticipation (HP:0003743)	3.40328371
8	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.22924562
9	Split foot (HP:0001839)	3.21393895
10	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.11881154
11	Absent/shortened dynein arms (HP:0200106)	3.11881154
12	Focal motor seizures (HP:0011153)	3.07326027
13	Abnormality of midbrain morphology (HP:0002418)	3.06043247
14	Molar tooth sign on MRI (HP:0002419)	3.06043247
15	Medial flaring of the eyebrow (HP:0010747)	2.94047449
16	Pendular nystagmus (HP:0012043)	2.91741310
17	Pancreatic cysts (HP:0001737)	2.87260319
18	Progressive cerebellar ataxia (HP:0002073)	2.83529548
19	Tubulointerstitial fibrosis (HP:0005576)	2.80897155
20	Abnormal ciliary motility (HP:0012262)	2.77605630
21	Septo-optic dysplasia (HP:0100842)	2.69271691
22	Arthropathy (HP:0003040)	2.66087384
23	Abnormal respiratory motile cilium physiology (HP:0012261)	2.65581777
24	Type I transferrin isoform profile (HP:0003642)	2.65079388
25	Abnormal respiratory epithelium morphology (HP:0012253)	2.64031840
26	Abnormal respiratory motile cilium morphology (HP:0005938)	2.64031840
27	Choroideremia (HP:0001139)	2.59069934
28	Megalencephaly (HP:0001355)	2.55032892
29	Hypoplastic pelvis (HP:0008839)	2.55000706
30	Concave nail (HP:0001598)	2.53227183
31	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.52794931
32	Abnormality of alanine metabolism (HP:0010916)	2.52794931
33	Hyperalaninemia (HP:0003348)	2.52794931
34	Pancreatic fibrosis (HP:0100732)	2.51925876
35	Congenital, generalized hypertrichosis (HP:0004540)	2.51227574
36	Dyschromatopsia (HP:0007641)	2.49579930
37	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.45742006
38	Abnormal protein N-linked glycosylation (HP:0012347)	2.45742006
39	Abnormal protein glycosylation (HP:0012346)	2.45742006
40	Abnormal glycosylation (HP:0012345)	2.45742006
41	Birth length less than 3rd percentile (HP:0003561)	2.38236676
42	Rhinitis (HP:0012384)	2.37849801
43	Congenital primary aphakia (HP:0007707)	2.37038997
44	Gait imbalance (HP:0002141)	2.36897991
45	Dialeptic seizures (HP:0011146)	2.33716785
46	Hypoplasia of the capital femoral epiphysis (HP:0003090)	2.30870830
47	Nephronophthisis (HP:0000090)	2.30115201
48	Tented upper lip vermilion (HP:0010804)	2.28043393
49	Reduced antithrombin III activity (HP:0001976)	2.25413115
50	Rib fusion (HP:0000902)	2.22072085
51	Stenosis of the external auditory canal (HP:0000402)	2.22006718
52	Adrenal hypoplasia (HP:0000835)	2.21551325
53	Oligodactyly (hands) (HP:0001180)	2.21406214
54	Neonatal respiratory distress (HP:0002643)	2.20712553
55	Genital tract atresia (HP:0001827)	2.20278838
56	Premature ovarian failure (HP:0008209)	2.18832322
57	Vaginal atresia (HP:0000148)	2.18532959
58	Meckel diverticulum (HP:0002245)	2.16757385
59	Intestinal atresia (HP:0011100)	2.16062206
60	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.11801132
61	Progressive hearing impairment (HP:0001730)	2.11190333
62	Anophthalmia (HP:0000528)	2.10308202
63	Abnormality of macular pigmentation (HP:0008002)	2.10265780
64	Sclerocornea (HP:0000647)	2.06954895
65	Nephrogenic diabetes insipidus (HP:0009806)	2.06764734
66	Gastrointestinal atresia (HP:0002589)	2.06137564
67	Abnormality of the ileum (HP:0001549)	2.04020037
68	Tubulointerstitial abnormality (HP:0001969)	2.03161181
69	Abnormality of the duodenum (HP:0002246)	2.03031488
70	Exotropia (HP:0000577)	1.99342202
71	Elevated erythrocyte sedimentation rate (HP:0003565)	1.98906960
72	Oculomotor apraxia (HP:0000657)	1.96825096
73	Duodenal stenosis (HP:0100867)	1.95845817
74	Small intestinal stenosis (HP:0012848)	1.95845817
75	Chronic bronchitis (HP:0004469)	1.95622482
76	Abnormality of the renal medulla (HP:0100957)	1.95553078
77	Abnormality of the renal cortex (HP:0011035)	1.95280265
78	Aplasia of the musculature (HP:0100854)	1.94336018
79	Constricted visual fields (HP:0001133)	1.94150042
80	Abnormality of chromosome stability (HP:0003220)	1.93444783
81	Central scotoma (HP:0000603)	1.92691520
82	Patellar aplasia (HP:0006443)	1.92072016
83	Lipid accumulation in hepatocytes (HP:0006561)	1.89100726
84	Oral leukoplakia (HP:0002745)	1.88641330
85	Thickened helices (HP:0000391)	1.85451597
86	Abnormality of the carotid arteries (HP:0005344)	1.85245313
87	Preaxial hand polydactyly (HP:0001177)	1.84723209
88	Hyperventilation (HP:0002883)	1.83807315
89	Progressive inability to walk (HP:0002505)	1.82643187
90	Esophageal atresia (HP:0002032)	1.80355516
91	Abnormality of the diencephalon (HP:0010662)	1.79869631
92	Hyperphosphaturia (HP:0003109)	1.77670859
93	Postaxial hand polydactyly (HP:0001162)	1.76781954
94	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.76331159
95	Chronic hepatic failure (HP:0100626)	1.76223904
96	Irregular vertebral endplates (HP:0003301)	1.74806793
97	Small hand (HP:0200055)	1.74804317
98	Renal hypoplasia (HP:0000089)	1.74729206
99	Aplasia/Hypoplasia of the patella (HP:0006498)	1.74339264
100	Absent speech (HP:0001344)	1.73077120

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	IRAK2	4.55445088
2	FRK	4.30555441
3	IRAK1	4.09881767
4	NEK1	3.64269076
5	ADRBK2	3.14222519
6	EIF2AK3	2.56237826
7	CDK8	2.49007904
8	VRK1	2.34832624
9	ZAK	2.22538370
10	CDK3	2.20293179
11	NUAK1	2.17135207
12	MAPK15	2.15335406
13	PLK2	2.05926449
14	MAPK13	1.99443171
15	DYRK2	1.97954926
16	LATS1	1.97470675
17	PLK4	1.92205206
18	STK38L	1.76192107
19	YES1	1.62396769
20	EPHA3	1.61066993
21	CDC7	1.59850229
22	TGFBR2	1.49836993
23	GRK7	1.44672305
24	CAMKK2	1.40283729
25	ERBB3	1.36736391
26	WEE1	1.33500576
27	BCR	1.33310368
28	TLK1	1.28448661
29	VRK2	1.28182429
30	MAP3K7	1.27033979
31	PLK3	1.20916864
32	CASK	1.18995523
33	ACVR1B	1.17468060
34	CAMK1D	1.09561750
35	WNK3	1.07676428
36	BRSK2	1.05433003
37	MUSK	1.04733095
38	PRKD3	1.03134505
39	PRKCE	0.98052755
40	INSRR	0.95941676
41	PTK2B	0.90241574
42	RPS6KA4	0.88192246
43	EIF2AK2	0.86728627
44	PNCK	0.86379102
45	ADRBK1	0.83645824
46	BMPR1B	0.82694446
47	UHMK1	0.81824132
48	ILK	0.80493124
49	EPHB2	0.77661824
50	EIF2AK1	0.75979972
51	MARK1	0.75320188
52	PDK2	0.74639645
53	MOS	0.72041925
54	ROCK1	0.70063841
55	PRKCG	0.69845421
56	MKNK2	0.68887857
57	TGFBR1	0.68332610
58	PINK1	0.67636547
59	MAP3K4	0.67205451
60	MELK	0.66995370
61	PIK3CG	0.66694511
62	PAK6	0.66671050
63	DYRK3	0.65334925
64	PLK1	0.65119207
65	MAP2K2	0.61730184
66	MAP3K9	0.61264808
67	MINK1	0.58758125
68	ROCK2	0.58643784
69	DMPK	0.57071873
70	CAMK2A	0.55592474
71	TAOK1	0.52897370
72	PASK	0.52161407
73	BRSK1	0.49782098
74	EPHA4	0.48853741
75	SRPK1	0.46555546
76	GRK1	0.45525575
77	CAMK1G	0.44786650
78	RAF1	0.40256074
79	DYRK1B	0.39265205
80	NEK2	0.38243461
81	NEK6	0.36123402
82	ATR	0.34460251
83	PRKACB	0.34445841
84	DAPK2	0.33742588
85	CSNK1G2	0.33124070
86	TSSK6	0.31417520
87	LATS2	0.30866712
88	PRKACA	0.29268605
89	CAMK4	0.28819732
90	NTRK3	0.27429082
91	CSNK1A1	0.26971802
92	PRKG1	0.26482181
93	CSNK1E	0.25600629
94	CAMK2B	0.25566801
95	PRKCQ	0.25329701
96	CDK4	0.24525436
97	MKNK1	0.24443189
98	BCKDK	0.24389656
99	CSF1R	0.23592238
100	AURKB	0.23119184

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	5.51880468
2	Protein export_Homo sapiens_hsa03060	2.70875451
3	Fatty acid biosynthesis_Homo sapiens_hsa00061	2.67647922
4	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.44549287
5	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.42353778
6	Oxidative phosphorylation_Homo sapiens_hsa00190	2.29583341
7	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	2.23870482
8	Non-homologous end-joining_Homo sapiens_hsa03450	2.19354575
9	Homologous recombination_Homo sapiens_hsa03440	2.04794621
10	Steroid biosynthesis_Homo sapiens_hsa00100	1.99007525
11	Phototransduction_Homo sapiens_hsa04744	1.90385599
12	Butanoate metabolism_Homo sapiens_hsa00650	1.88944185
13	Parkinsons disease_Homo sapiens_hsa05012	1.85253238
14	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.80748538
15	Linoleic acid metabolism_Homo sapiens_hsa00591	1.79316998
16	Cardiac muscle contraction_Homo sapiens_hsa04260	1.77231399
17	Nicotine addiction_Homo sapiens_hsa05033	1.74708345
18	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.69725011
19	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.68044311
20	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.65366596
21	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.63893307
22	Basal transcription factors_Homo sapiens_hsa03022	1.54963577
23	Chemical carcinogenesis_Homo sapiens_hsa05204	1.52126008
24	Huntingtons disease_Homo sapiens_hsa05016	1.47224682
25	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.46021813
26	Nitrogen metabolism_Homo sapiens_hsa00910	1.42849795
27	Glutathione metabolism_Homo sapiens_hsa00480	1.38160229
28	Nucleotide excision repair_Homo sapiens_hsa03420	1.36501406
29	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.34698798
30	Fanconi anemia pathway_Homo sapiens_hsa03460	1.30171426
31	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.26089281
32	Pyruvate metabolism_Homo sapiens_hsa00620	1.23041986
33	Taste transduction_Homo sapiens_hsa04742	1.19775452
34	GABAergic synapse_Homo sapiens_hsa04727	1.16663567
35	Base excision repair_Homo sapiens_hsa03410	1.15496475
36	TGF-beta signaling pathway_Homo sapiens_hsa04350	1.14332480
37	Morphine addiction_Homo sapiens_hsa05032	1.10873022
38	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.09314262
39	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.08514465
40	Olfactory transduction_Homo sapiens_hsa04740	1.07144982
41	Caffeine metabolism_Homo sapiens_hsa00232	1.07080962
42	Cholinergic synapse_Homo sapiens_hsa04725	1.06798222
43	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.04651564
44	Propanoate metabolism_Homo sapiens_hsa00640	1.04611654
45	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.02065752
46	Alzheimers disease_Homo sapiens_hsa05010	0.98531974
47	Regulation of autophagy_Homo sapiens_hsa04140	0.96783664
48	Fatty acid metabolism_Homo sapiens_hsa01212	0.96673143
49	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.92638741
50	Sphingolipid metabolism_Homo sapiens_hsa00600	0.91961789
51	Fat digestion and absorption_Homo sapiens_hsa04975	0.88041680
52	Fatty acid elongation_Homo sapiens_hsa00062	0.87051276
53	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.86374799
54	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.86281545
55	Retinol metabolism_Homo sapiens_hsa00830	0.86113538
56	Sulfur relay system_Homo sapiens_hsa04122	0.84580429
57	beta-Alanine metabolism_Homo sapiens_hsa00410	0.82487078
58	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.80200185
59	Fatty acid degradation_Homo sapiens_hsa00071	0.78163331
60	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.76030245
61	Tryptophan metabolism_Homo sapiens_hsa00380	0.75745905
62	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.75605313
63	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.73702884
64	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.72785786
65	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.68566382
66	Ether lipid metabolism_Homo sapiens_hsa00565	0.67111998
67	RNA degradation_Homo sapiens_hsa03018	0.67059984
68	Glutamatergic synapse_Homo sapiens_hsa04724	0.65884869
69	Axon guidance_Homo sapiens_hsa04360	0.65468938
70	Pyrimidine metabolism_Homo sapiens_hsa00240	0.64843586
71	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.64063994
72	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.62108260
73	RNA transport_Homo sapiens_hsa03013	0.59911585
74	DNA replication_Homo sapiens_hsa03030	0.59622739
75	Salivary secretion_Homo sapiens_hsa04970	0.59575984
76	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.59089609
77	Insulin secretion_Homo sapiens_hsa04911	0.58649385
78	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.58291753
79	Circadian entrainment_Homo sapiens_hsa04713	0.57136597
80	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.56184214
81	Dopaminergic synapse_Homo sapiens_hsa04728	0.55968926
82	ABC transporters_Homo sapiens_hsa02010	0.55829947
83	Proteasome_Homo sapiens_hsa03050	0.54365827
84	Hippo signaling pathway_Homo sapiens_hsa04390	0.54170315
85	Metabolic pathways_Homo sapiens_hsa01100	0.52539496
86	Ribosome_Homo sapiens_hsa03010	0.52469492
87	Serotonergic synapse_Homo sapiens_hsa04726	0.49791175
88	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.48685952
89	Purine metabolism_Homo sapiens_hsa00230	0.45274493
90	Renin-angiotensin system_Homo sapiens_hsa04614	0.44977725
91	Peroxisome_Homo sapiens_hsa04146	0.43579482
92	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.43231826
93	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.39409746
94	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.38478750
95	Basal cell carcinoma_Homo sapiens_hsa05217	0.38165464
96	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.36576995
97	Cell cycle_Homo sapiens_hsa04110	0.34777668
98	cAMP signaling pathway_Homo sapiens_hsa04024	0.33753439
99	Gap junction_Homo sapiens_hsa04540	0.33410193
100	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.32989233

DCAF13P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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