ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	8.57038256
2	leukotriene biosynthetic process (GO:0019370)	6.52424591
3	methionine biosynthetic process (GO:0009086)	6.17928605
4	protein K6-linked ubiquitination (GO:0085020)	6.01421666
5	positive regulation of heterotypic cell-cell adhesion (GO:0034116)	5.82355899
6	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	5.73547537
7	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	5.61275279
8	transcription from mitochondrial promoter (GO:0006390)	5.57847607
9	regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)	5.52085116
10	positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)	5.52085116
11	regulation of retinoic acid receptor signaling pathway (GO:0048385)	5.42458502
12	methionine metabolic process (GO:0006555)	5.00014462
13	muscle organ morphogenesis (GO:0048644)	4.91299704
14	sulfur amino acid biosynthetic process (GO:0000097)	4.84004468
15	DNA deamination (GO:0045006)	4.75163318
16	aspartate family amino acid biosynthetic process (GO:0009067)	4.70168976
17	phosphatidylethanolamine metabolic process (GO:0046337)	4.68967004
18	glutathione biosynthetic process (GO:0006750)	4.66030024
19	L-methionine salvage (GO:0071267)	4.58220705
20	L-methionine biosynthetic process (GO:0071265)	4.58220705
21	amino acid salvage (GO:0043102)	4.58220705
22	nonribosomal peptide biosynthetic process (GO:0019184)	4.55065999
23	proteasome assembly (GO:0043248)	4.55020804
24	response to pheromone (GO:0019236)	4.50814444
25	ribosome assembly (GO:0042255)	4.49872286
26	viral mRNA export from host cell nucleus (GO:0046784)	4.49461432
27	mitotic metaphase plate congression (GO:0007080)	4.45657300
28	alanine transport (GO:0032328)	4.37868668
29	interferon-gamma secretion (GO:0072643)	4.31986765
30	proline transport (GO:0015824)	4.20503373
31	microtubule depolymerization (GO:0007019)	4.11626097
32	metaphase plate congression (GO:0051310)	3.96441644
33	valine metabolic process (GO:0006573)	3.94510520
34	icosanoid biosynthetic process (GO:0046456)	3.86875138
35	fatty acid derivative biosynthetic process (GO:1901570)	3.86875138
36	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.80210377
37	respiratory chain complex IV assembly (GO:0008535)	3.75649829
38	protein neddylation (GO:0045116)	3.66381192
39	DNA replication-dependent nucleosome organization (GO:0034723)	3.65444852
40	DNA replication-dependent nucleosome assembly (GO:0006335)	3.65444852
41	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.63385575
42	leukotriene metabolic process (GO:0006691)	3.61962776
43	regulation of alternative mRNA splicing, via spliceosome (GO:0000381)	3.60993430
44	mitochondrial RNA metabolic process (GO:0000959)	3.57117315
45	CENP-A containing nucleosome assembly (GO:0034080)	3.50014975
46	natural killer cell activation involved in immune response (GO:0002323)	3.47571995
47	protein heterotetramerization (GO:0051290)	3.45271178
48	protein K11-linked deubiquitination (GO:0035871)	3.38774118
49	fucose catabolic process (GO:0019317)	3.38170037
50	L-fucose metabolic process (GO:0042354)	3.38170037
51	L-fucose catabolic process (GO:0042355)	3.38170037
52	chromatin remodeling at centromere (GO:0031055)	3.35377873
53	glutathione derivative metabolic process (GO:1901685)	3.30607694
54	glutathione derivative biosynthetic process (GO:1901687)	3.30607694
55	regulation of MHC class I biosynthetic process (GO:0045343)	3.20933341
56	phosphatidylethanolamine biosynthetic process (GO:0006646)	3.20724273
57	glycerophospholipid catabolic process (GO:0046475)	3.20642447
58	unsaturated fatty acid biosynthetic process (GO:0006636)	3.18222116
59	male meiosis I (GO:0007141)	3.13027393
60	maturation of 5.8S rRNA (GO:0000460)	3.11846133
61	establishment of chromosome localization (GO:0051303)	3.11195519
62	nucleoside salvage (GO:0043174)	3.11074740
63	water-soluble vitamin biosynthetic process (GO:0042364)	3.08292262
64	prenylation (GO:0097354)	3.01848157
65	protein prenylation (GO:0018342)	3.01848157
66	glutathione metabolic process (GO:0006749)	3.01451592
67	gastrulation with mouth forming second (GO:0001702)	2.89724202
68	negative regulation of viral transcription (GO:0032897)	2.87891477
69	peptide biosynthetic process (GO:0043043)	2.86741992
70	telomere maintenance via recombination (GO:0000722)	2.85340180
71	negative regulation of interleukin-2 production (GO:0032703)	2.83731347
72	mitotic cell cycle arrest (GO:0071850)	2.83344449
73	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.82601213
74	cytochrome complex assembly (GO:0017004)	2.79253573
75	purine-containing compound salvage (GO:0043101)	2.76789474
76	cysteine metabolic process (GO:0006534)	2.75028671
77	positive regulation of protein import into nucleus, translocation (GO:0033160)	2.74011203
78	magnesium ion transport (GO:0015693)	2.73928443
79	mitotic recombination (GO:0006312)	2.73509511
80	telomere maintenance via semi-conservative replication (GO:0032201)	2.73208807
81	synapsis (GO:0007129)	2.72931162
82	lymphangiogenesis (GO:0001946)	2.68383426
83	regulation of mRNA splicing, via spliceosome (GO:0048024)	2.67553266
84	pancreas development (GO:0031016)	2.67519532
85	response to folic acid (GO:0051593)	2.67169507
86	estrogen biosynthetic process (GO:0006703)	2.65813553
87	histone exchange (GO:0043486)	2.65429418
88	negative regulation of oligodendrocyte differentiation (GO:0048715)	2.64481703
89	mitotic sister chromatid cohesion (GO:0007064)	2.60823155
90	dopamine transport (GO:0015872)	2.60046020
91	DNA double-strand break processing (GO:0000729)	2.57913049
92	histone mRNA catabolic process (GO:0071044)	2.55000202
93	cellular respiration (GO:0045333)	2.51443673
94	negative regulation of fibroblast apoptotic process (GO:2000270)	2.51345687
95	branched-chain amino acid catabolic process (GO:0009083)	2.51333174
96	negative regulation by host of viral transcription (GO:0043922)	2.50297266
97	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.50230400
98	poly(A)+ mRNA export from nucleus (GO:0016973)	2.49873542
99	piRNA metabolic process (GO:0034587)	2.49501222
100	sulfur amino acid metabolic process (GO:0000096)	2.48100128

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	4.39132023
2	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.60352580
3	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.18152848
4	GATA1_22025678_ChIP-Seq_K562_Human	2.88359582
5	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.81414025
6	SMAD_19615063_ChIP-ChIP_OVARY_Human	2.72920515
7	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.71556480
8	ZNF274_21170338_ChIP-Seq_K562_Hela	2.63761190
9	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.63448970
10	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.58578552
11	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.50517421
12	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.40536844
13	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.33701441
14	ELK1_19687146_ChIP-ChIP_HELA_Human	2.32838938
15	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.32364844
16	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.31958624
17	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.20136034
18	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.02733513
19	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.02682880
20	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.93126036
21	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.93082722
22	AR_21572438_ChIP-Seq_LNCaP_Human	1.85301670
23	EWS_26573619_Chip-Seq_HEK293_Human	1.84767393
24	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.83782144
25	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.78373120
26	E2F7_22180533_ChIP-Seq_HELA_Human	1.75441462
27	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.74469269
28	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.72920467
29	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.71698140
30	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.71364574
31	VDR_23849224_ChIP-Seq_CD4+_Human	1.68137165
32	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.66057051
33	TAF15_26573619_Chip-Seq_HEK293_Human	1.64427675
34	P300_19829295_ChIP-Seq_ESCs_Human	1.60279726
35	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.56111150
36	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.54774442
37	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.54022330
38	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.53376542
39	GBX2_23144817_ChIP-Seq_PC3_Human	1.52039715
40	ER_23166858_ChIP-Seq_MCF-7_Human	1.50167315
41	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.50107746
42	VDR_22108803_ChIP-Seq_LS180_Human	1.48698615
43	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.47306759
44	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.43596710
45	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.42552326
46	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.40626789
47	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.39670367
48	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.38689438
49	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.34611075
50	TCF4_23295773_ChIP-Seq_U87_Human	1.34609857
51	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.33984892
52	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.33473590
53	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.33228377
54	BCAT_22108803_ChIP-Seq_LS180_Human	1.30564981
55	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.27154508
56	HTT_18923047_ChIP-ChIP_STHdh_Human	1.26839353
57	EZH2_22144423_ChIP-Seq_EOC_Human	1.26416629
58	SMAD4_21799915_ChIP-Seq_A2780_Human	1.25418260
59	STAT3_23295773_ChIP-Seq_U87_Human	1.25359136
60	FUS_26573619_Chip-Seq_HEK293_Human	1.22952649
61	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.21693550
62	CBP_20019798_ChIP-Seq_JUKART_Human	1.21693550
63	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.19658854
64	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.19360227
65	SOX2_19829295_ChIP-Seq_ESCs_Human	1.19224683
66	NANOG_19829295_ChIP-Seq_ESCs_Human	1.19224683
67	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.19110989
68	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.18850350
69	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.18412919
70	IGF1R_20145208_ChIP-Seq_DFB_Human	1.17192949
71	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.14739140
72	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.13112646
73	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.13042200
74	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.12110289
75	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.11857417
76	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.10930510
77	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.08052464
78	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.07435749
79	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.06579741
80	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.04694391
81	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.04602844
82	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.04258547
83	HOXB7_26014856_ChIP-Seq_BT474_Human	1.04196931
84	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.03642546
85	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.03046811
86	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.02924408
87	AR_25329375_ChIP-Seq_VCAP_Human	1.01920493
88	NCOR_22424771_ChIP-Seq_293T_Human	1.01760822
89	GATA3_26560356_Chip-Seq_TH2_Human	1.01087658
90	TCF4_22108803_ChIP-Seq_LS180_Human	1.00592059
91	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.99960302
92	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.99616357
93	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.98901725
94	CDX2_22108803_ChIP-Seq_LS180_Human	0.96951689
95	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.96850254
96	FOXP3_21729870_ChIP-Seq_TREG_Human	0.96770496
97	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.96697733
98	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.96422912
99	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.96422912
100	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.95421557

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003195_calcinosis	5.90582225
2	MP0000569_abnormal_digit_pigmentation	5.34403785
3	MP0003646_muscle_fatigue	3.99301381
4	MP0003011_delayed_dark_adaptation	3.93117679
5	MP0002876_abnormal_thyroid_physiology	3.87959842
6	MP0005645_abnormal_hypothalamus_physiol	3.38693137
7	MP0005646_abnormal_pituitary_gland	3.08053837
8	MP0008995_early_reproductive_senescence	2.74737843
9	MP0008877_abnormal_DNA_methylation	2.66572402
10	MP0010094_abnormal_chromosome_stability	2.25761689
11	MP0008057_abnormal_DNA_replication	2.19585557
12	MP0003786_premature_aging	2.15057667
13	MP0001905_abnormal_dopamine_level	2.09197643
14	MP0005647_abnormal_sex_gland	2.00406664
15	MP0001529_abnormal_vocalization	1.94676504
16	MP0008872_abnormal_physiological_respon	1.94645233
17	MP0002277_abnormal_respiratory_mucosa	1.93447699
18	MP0003693_abnormal_embryo_hatching	1.86313249
19	MP0008058_abnormal_DNA_repair	1.86206571
20	MP0006035_abnormal_mitochondrial_morpho	1.79687480
21	MP0004147_increased_porphyrin_level	1.78732524
22	MP0003718_maternal_effect	1.69987261
23	MP0001873_stomach_inflammation	1.67662731
24	MP0002163_abnormal_gland_morphology	1.64785630
25	MP0000631_abnormal_neuroendocrine_gland	1.50546192
26	MP0010307_abnormal_tumor_latency	1.47989316
27	MP0003880_abnormal_central_pattern	1.33934322
28	MP0006072_abnormal_retinal_apoptosis	1.31079684
29	MP0005253_abnormal_eye_physiology	1.29303068
30	MP0005671_abnormal_response_to	1.26970136
31	MP0005551_abnormal_eye_electrophysiolog	1.26813167
32	MP0009697_abnormal_copulation	1.25231929
33	MP0009046_muscle_twitch	1.24481456
34	MP0000639_abnormal_adrenal_gland	1.19223875
35	MP0005332_abnormal_amino_acid	1.19067649
36	MP0005220_abnormal_exocrine_pancreas	1.15734697
37	MP0001119_abnormal_female_reproductive	1.15120099
38	MP0002938_white_spotting	1.14376124
39	MP0008875_abnormal_xenobiotic_pharmacok	1.12552698
40	MP0001835_abnormal_antigen_presentation	1.10336375
41	MP0006036_abnormal_mitochondrial_physio	1.09413035
42	MP0002653_abnormal_ependyma_morphology	1.08126365
43	MP0003806_abnormal_nucleotide_metabolis	1.06872035
44	MP0005395_other_phenotype	1.05223130
45	MP0006292_abnormal_olfactory_placode	1.04567196
46	MP0006082_CNS_inflammation	1.04517416
47	MP0009785_altered_susceptibility_to	1.04268939
48	MP0005386_behavior/neurological_phenoty	1.02858271
49	MP0004924_abnormal_behavior	1.02858271
50	MP0001293_anophthalmia	0.99829899
51	MP0005410_abnormal_fertilization	0.99701620
52	MP0006276_abnormal_autonomic_nervous	0.99315208
53	MP0002332_abnormal_exercise_endurance	0.98720916
54	MP0002229_neurodegeneration	0.98369568
55	MP0003077_abnormal_cell_cycle	0.96592571
56	MP0000685_abnormal_immune_system	0.93447375
57	MP0001929_abnormal_gametogenesis	0.91000186
58	MP0005266_abnormal_metabolism	0.90802248
59	MP0005389_reproductive_system_phenotype	0.90113785
60	MP0001764_abnormal_homeostasis	0.88770925
61	MP0004142_abnormal_muscle_tone	0.88255335
62	MP0002751_abnormal_autonomic_nervous	0.87698363
63	MP0002166_altered_tumor_susceptibility	0.86924978
64	MP0002210_abnormal_sex_determination	0.86853457
65	MP0000013_abnormal_adipose_tissue	0.86447054
66	MP0003698_abnormal_male_reproductive	0.85158110
67	MP0001919_abnormal_reproductive_system	0.81460374
68	MP0002102_abnormal_ear_morphology	0.81340345
69	MP0002168_other_aberrant_phenotype	0.80070302
70	MP0003943_abnormal_hepatobiliary_system	0.79326618
71	MP0003656_abnormal_erythrocyte_physiolo	0.77767267
72	MP0003787_abnormal_imprinting	0.76994035
73	MP0004742_abnormal_vestibular_system	0.75543158
74	MP0001486_abnormal_startle_reflex	0.74527613
75	MP0000653_abnormal_sex_gland	0.72231880
76	MP0002254_reproductive_system_inflammat	0.70728099
77	MP0003111_abnormal_nucleus_morphology	0.69913872
78	MP0002160_abnormal_reproductive_system	0.69537760
79	MP0002933_joint_inflammation	0.69229223
80	MP0002272_abnormal_nervous_system	0.68243883
81	MP0002837_dystrophic_cardiac_calcinosis	0.67956671
82	MP0001191_abnormal_skin_condition	0.67886192
83	MP0002148_abnormal_hypersensitivity_rea	0.66291654
84	MP0002006_tumorigenesis	0.66275738
85	MP0005174_abnormal_tail_pigmentation	0.66007472
86	MP0005367_renal/urinary_system_phenotyp	0.65955062
87	MP0000516_abnormal_urinary_system	0.65955062
88	MP0001145_abnormal_male_reproductive	0.65782582
89	MP0001879_abnormal_lymphatic_vessel	0.64833348
90	MP0002557_abnormal_social/conspecific_i	0.63876846
91	MP0004133_heterotaxia	0.61007298
92	MP0004484_altered_response_of	0.60154602
93	MP0002736_abnormal_nociception_after	0.59892232
94	MP0004134_abnormal_chest_morphology	0.59664520
95	MP0001968_abnormal_touch/_nociception	0.59501028
96	MP0003937_abnormal_limbs/digits/tail_de	0.59458646
97	MP0005379_endocrine/exocrine_gland_phen	0.59012928
98	MP0003567_abnormal_fetal_cardiomyocyte	0.58499373
99	MP0001986_abnormal_taste_sensitivity	0.57604283
100	MP0005391_vision/eye_phenotype	0.56765567

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of homocysteine metabolism (HP:0010919)	5.22543821
2	Homocystinuria (HP:0002156)	5.22543821
3	Increased density of long bones (HP:0006392)	4.26283421
4	Abnormality of methionine metabolism (HP:0010901)	4.06719184
5	Pustule (HP:0200039)	3.85565558
6	Central scotoma (HP:0000603)	3.67401761
7	Abnormality of the vitamin B12 metabolism (HP:0004341)	3.53289342
8	Pancreatic fibrosis (HP:0100732)	3.42422155
9	True hermaphroditism (HP:0010459)	3.38342038
10	Abnormality of vitamin B metabolism (HP:0004340)	3.37162727
11	Pancreatic cysts (HP:0001737)	3.33783116
12	Abnormality of macular pigmentation (HP:0008002)	3.27255804
13	Megaloblastic anemia (HP:0001889)	3.21203692
14	Increased circulating renin level (HP:0000848)	3.21152463
15	Aplasia/Hypoplasia of the uvula (HP:0010293)	3.19648128
16	Meckel diverticulum (HP:0002245)	3.06265419
17	Abnormality of aspartate family amino acid metabolism (HP:0010899)	3.03947787
18	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.89947130
19	Absent/shortened dynein arms (HP:0200106)	2.89947130
20	Abnormality of the ileum (HP:0001549)	2.87554277
21	Molar tooth sign on MRI (HP:0002419)	2.84253682
22	Abnormality of midbrain morphology (HP:0002418)	2.84253682
23	Pheochromocytoma (HP:0002666)	2.77362976
24	Renal cortical cysts (HP:0000803)	2.68522923
25	Increased hepatocellular lipid droplets (HP:0006565)	2.68201022
26	Hypokalemic alkalosis (HP:0001949)	2.59165425
27	Attenuation of retinal blood vessels (HP:0007843)	2.53175806
28	Abnormality of the fovea (HP:0000493)	2.51714147
29	Supernumerary spleens (HP:0009799)	2.51702546
30	Abnormality of chromosome stability (HP:0003220)	2.50718266
31	Abnormality of the preputium (HP:0100587)	2.50059478
32	Dyskinesia (HP:0100660)	2.49988531
33	Neuroendocrine neoplasm (HP:0100634)	2.49340606
34	Abnormality of sulfur amino acid metabolism (HP:0004339)	2.48941091
35	Submucous cleft hard palate (HP:0000176)	2.46902928
36	Midline defect of the nose (HP:0004122)	2.46864045
37	Abnormal drinking behavior (HP:0030082)	2.45533436
38	Polydipsia (HP:0001959)	2.45533436
39	Decreased central vision (HP:0007663)	2.39760613
40	Anencephaly (HP:0002323)	2.37309515
41	Nephronophthisis (HP:0000090)	2.36318487
42	Lipid accumulation in hepatocytes (HP:0006561)	2.34459669
43	Azoospermia (HP:0000027)	2.29260795
44	Amyotrophic lateral sclerosis (HP:0007354)	2.29253386
45	Carpal bone hypoplasia (HP:0001498)	2.28138234
46	Hypomagnesemia (HP:0002917)	2.27563374
47	Clubbing of toes (HP:0100760)	2.23074914
48	Pendular nystagmus (HP:0012043)	2.22501630
49	Oligodactyly (hands) (HP:0001180)	2.22029659
50	Abnormality of vitamin metabolism (HP:0100508)	2.21943619
51	Diastasis recti (HP:0001540)	2.21823207
52	Abolished electroretinogram (ERG) (HP:0000550)	2.21224389
53	Abnormal spermatogenesis (HP:0008669)	2.19415310
54	Scotoma (HP:0000575)	2.14393239
55	Abnormality of serum amino acid levels (HP:0003112)	2.14189305
56	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.12687972
57	Premature graying of hair (HP:0002216)	2.12205608
58	Small intestinal stenosis (HP:0012848)	2.11978198
59	Duodenal stenosis (HP:0100867)	2.11978198
60	Meningioma (HP:0002858)	2.11736539
61	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.11082157
62	Abnormality of the renal medulla (HP:0100957)	2.09664868
63	Gonadotropin excess (HP:0000837)	2.09174476
64	Nausea (HP:0002018)	2.06418158
65	Renal Fanconi syndrome (HP:0001994)	2.06147179
66	Chronic hepatic failure (HP:0100626)	2.06036546
67	Focal motor seizures (HP:0011153)	2.00586529
68	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.00397024
69	Cystic liver disease (HP:0006706)	2.00393726
70	Eosinophilia (HP:0001880)	2.00249239
71	Soft skin (HP:0000977)	1.99934493
72	Abnormality of the duodenum (HP:0002246)	1.96209843
73	Short tibia (HP:0005736)	1.95772164
74	Arthropathy (HP:0003040)	1.94523553
75	Abnormality of the renal cortex (HP:0011035)	1.94372164
76	Leukocytosis (HP:0001974)	1.93099188
77	Mitochondrial inheritance (HP:0001427)	1.92372532
78	Acute necrotizing encephalopathy (HP:0006965)	1.90135096
79	Genetic anticipation (HP:0003743)	1.85971444
80	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	1.84236971
81	Rhabdomyosarcoma (HP:0002859)	1.81581408
82	Abnormality of the pons (HP:0007361)	1.81486132
83	Keratoconus (HP:0000563)	1.77718370
84	Increased corneal curvature (HP:0100692)	1.77718370
85	Increased CSF lactate (HP:0002490)	1.77098770
86	Poor speech (HP:0002465)	1.76747067
87	Hypoplasia of the pons (HP:0012110)	1.76495591
88	Type 2 muscle fiber atrophy (HP:0003554)	1.75582278
89	Abnormal rod and cone electroretinograms (HP:0008323)	1.75314513
90	Glioma (HP:0009733)	1.73377611
91	Progressive inability to walk (HP:0002505)	1.72507673
92	Abnormality of eosinophils (HP:0001879)	1.72282815
93	Methylmalonic acidemia (HP:0002912)	1.71524902
94	Abnormality of the carotid arteries (HP:0005344)	1.71399119
95	Tetany (HP:0001281)	1.70496747
96	Abnormality of renin-angiotensin system (HP:0000847)	1.69789628
97	Abnormal delayed hypersensitivity skin test (HP:0002963)	1.69482977
98	Congenital hepatic fibrosis (HP:0002612)	1.68685516
99	Abnormality of magnesium homeostasis (HP:0004921)	1.67166536
100	Exotropia (HP:0000577)	1.66061429

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EIF2AK1	3.64833278
2	ZAK	3.64209424
3	STK39	3.62477152
4	WNK4	3.52915711
5	BUB1	3.07978745
6	PINK1	2.96912853
7	TSSK6	2.78091528
8	EIF2AK3	2.76519503
9	NEK1	2.71775619
10	SRPK1	2.63979750
11	OXSR1	2.63432536
12	FRK	2.54877967
13	TLK1	2.23919407
14	CAMKK2	2.05804613
15	BRSK2	1.97885485
16	BMPR1B	1.93516817
17	MST4	1.81670401
18	NTRK3	1.69469387
19	WNK3	1.62657425
20	MAP4K2	1.60113862
21	TAOK3	1.56510992
22	VRK2	1.56196095
23	MAPKAPK5	1.45377299
24	VRK1	1.44617797
25	ACVR1B	1.43484035
26	TTK	1.34064703
27	ADRBK2	1.28833224
28	MAP3K12	1.26085485
29	PLK3	1.20795205
30	MAP2K6	1.18852806
31	PBK	1.18455377
32	MAP3K6	1.15302018
33	TGFBR2	1.15167232
34	MAPKAPK3	1.13772678
35	WEE1	1.09961977
36	PLK2	1.03087769
37	BRSK1	1.02922707
38	TEC	1.01982874
39	GRK1	1.01142017
40	TNIK	0.99481067
41	EIF2AK2	0.98876995
42	MAPK13	0.94025742
43	EPHA3	0.82488420
44	AURKB	0.82390673
45	MKNK1	0.82261867
46	ADRBK1	0.81071068
47	MAP3K5	0.77446918
48	STK38L	0.76519942
49	MKNK2	0.73961433
50	MINK1	0.72363373
51	TXK	0.69077948
52	PIK3CG	0.67039392
53	PLK1	0.66479889
54	BCR	0.65363024
55	CDK3	0.64022577
56	TYK2	0.63579729
57	SCYL2	0.63002688
58	NUAK1	0.60552920
59	MAP4K1	0.58548268
60	MAP3K14	0.53932104
61	LATS1	0.53441348
62	MAP2K4	0.49407585
63	INSRR	0.48732801
64	PRKG2	0.47871067
65	LCK	0.46078016
66	CDC7	0.45743507
67	ABL1	0.42297597
68	CSNK1G3	0.40303436
69	CLK1	0.39733540
70	ERBB2	0.38799843
71	TNK2	0.38701678
72	STK4	0.38404370
73	TAOK1	0.38082977
74	PKN1	0.37847524
75	CSNK1A1L	0.37341510
76	IKBKB	0.37330524
77	WNK1	0.37285719
78	ATM	0.37177370
79	STK11	0.36428375
80	MAP2K7	0.35748315
81	ATR	0.35573936
82	EPHB2	0.34372230
83	IGF1R	0.34330653
84	NME1	0.33281977
85	ABL2	0.32963468
86	CSNK1G1	0.32667253
87	CSNK1G2	0.30744483
88	PRKCQ	0.30636855
89	STK10	0.30350319
90	DAPK1	0.29325850
91	MYLK	0.28527257
92	EPHA4	0.28246992
93	STK16	0.28127302
94	PRKCE	0.27891278
95	CDK8	0.27606812
96	CHUK	0.27074183
97	TGFBR1	0.27000234
98	KDR	0.24667563
99	CSNK1D	0.24207420
100	CCNB1	0.23897521

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Selenocompound metabolism_Homo sapiens_hsa00450	4.43395596
2	Proteasome_Homo sapiens_hsa03050	3.70072515
3	Mismatch repair_Homo sapiens_hsa03430	3.45668277
4	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	3.28170233
5	Cyanoamino acid metabolism_Homo sapiens_hsa00460	3.17529222
6	Fanconi anemia pathway_Homo sapiens_hsa03460	3.11288980
7	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	3.02016242
8	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.71011916
9	Homologous recombination_Homo sapiens_hsa03440	2.69248825
10	One carbon pool by folate_Homo sapiens_hsa00670	2.59839439
11	Nucleotide excision repair_Homo sapiens_hsa03420	2.29239611
12	Non-homologous end-joining_Homo sapiens_hsa03450	2.20507128
13	Basal transcription factors_Homo sapiens_hsa03022	2.14778182
14	DNA replication_Homo sapiens_hsa03030	2.13797350
15	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.05615443
16	Protein export_Homo sapiens_hsa03060	1.75261323
17	Caffeine metabolism_Homo sapiens_hsa00232	1.71768908
18	Nitrogen metabolism_Homo sapiens_hsa00910	1.57665032
19	Regulation of autophagy_Homo sapiens_hsa04140	1.44969179
20	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.37437564
21	Primary immunodeficiency_Homo sapiens_hsa05340	1.37194889
22	Phototransduction_Homo sapiens_hsa04744	1.33372071
23	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.27870264
24	RNA polymerase_Homo sapiens_hsa03020	1.26917369
25	Folate biosynthesis_Homo sapiens_hsa00790	1.26914259
26	Oxidative phosphorylation_Homo sapiens_hsa00190	1.22270656
27	Propanoate metabolism_Homo sapiens_hsa00640	1.20626612
28	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.20355119
29	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.12657271
30	RNA transport_Homo sapiens_hsa03013	1.10569330
31	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.04114897
32	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.99991598
33	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.95853515
34	Cell cycle_Homo sapiens_hsa04110	0.94304827
35	Spliceosome_Homo sapiens_hsa03040	0.94103867
36	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.91083237
37	RNA degradation_Homo sapiens_hsa03018	0.90418743
38	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.89800139
39	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.88614996
40	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.88049647
41	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.87981399
42	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.86540686
43	Linoleic acid metabolism_Homo sapiens_hsa00591	0.86138789
44	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.85977870
45	Parkinsons disease_Homo sapiens_hsa05012	0.85845578
46	Measles_Homo sapiens_hsa05162	0.85134868
47	Pyrimidine metabolism_Homo sapiens_hsa00240	0.84349592
48	mRNA surveillance pathway_Homo sapiens_hsa03015	0.84287466
49	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.81877859
50	Allograft rejection_Homo sapiens_hsa05330	0.80289838
51	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.80128972
52	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.79369296
53	Butanoate metabolism_Homo sapiens_hsa00650	0.78403782
54	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.76468245
55	Asthma_Homo sapiens_hsa05310	0.73860950
56	Glutathione metabolism_Homo sapiens_hsa00480	0.73729139
57	Retinol metabolism_Homo sapiens_hsa00830	0.71989674
58	beta-Alanine metabolism_Homo sapiens_hsa00410	0.71935146
59	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.69577917
60	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.68753211
61	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.67228604
62	Purine metabolism_Homo sapiens_hsa00230	0.65518169
63	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.65091171
64	Rheumatoid arthritis_Homo sapiens_hsa05323	0.63702915
65	Olfactory transduction_Homo sapiens_hsa04740	0.63541036
66	Huntingtons disease_Homo sapiens_hsa05016	0.61565300
67	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.61462412
68	Malaria_Homo sapiens_hsa05144	0.60482095
69	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.57341088
70	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.54959895
71	Chemical carcinogenesis_Homo sapiens_hsa05204	0.53618694
72	Type I diabetes mellitus_Homo sapiens_hsa04940	0.53405782
73	p53 signaling pathway_Homo sapiens_hsa04115	0.53082275
74	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.52680380
75	Antigen processing and presentation_Homo sapiens_hsa04612	0.52090714
76	Glycerolipid metabolism_Homo sapiens_hsa00561	0.50816975
77	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.48421597
78	Sulfur metabolism_Homo sapiens_hsa00920	0.46395301
79	Base excision repair_Homo sapiens_hsa03410	0.46359156
80	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.44544416
81	Fatty acid elongation_Homo sapiens_hsa00062	0.44486870
82	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.42778192
83	Oocyte meiosis_Homo sapiens_hsa04114	0.42360422
84	Herpes simplex infection_Homo sapiens_hsa05168	0.42357917
85	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.41998378
86	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.39404635
87	Graft-versus-host disease_Homo sapiens_hsa05332	0.38469207
88	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.34848502
89	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.34687108
90	Collecting duct acid secretion_Homo sapiens_hsa04966	0.34415737
91	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.33530132
92	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.32572664
93	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.31884361
94	Metabolic pathways_Homo sapiens_hsa01100	0.31680606
95	Ether lipid metabolism_Homo sapiens_hsa00565	0.29398230
96	Peroxisome_Homo sapiens_hsa04146	0.28690669
97	Amphetamine addiction_Homo sapiens_hsa05031	0.28587815
98	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.27234936
99	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.25912030
100	Alzheimers disease_Homo sapiens_hsa05010	0.25082853

DCAF13P3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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