DCAF15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of erythrocyte differentiation (GO:0045647)5.30353646
2pre-miRNA processing (GO:0031054)4.91998406
3DNA unwinding involved in DNA replication (GO:0006268)4.47727786
4positive regulation of gamma-delta T cell activation (GO:0046645)4.23837715
5protein localization to kinetochore (GO:0034501)4.23184352
6heterochromatin organization (GO:0070828)4.10099710
7negative regulation of cell killing (GO:0031342)4.04403288
8negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.04403288
9modulation by symbiont of host defense response (GO:0052031)3.96821013
10modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.96821013
11modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.96821013
12positive regulation by organism of defense response of other organism involved in symbiotic interact3.96821013
13modulation by symbiont of host immune response (GO:0052553)3.96821013
14positive regulation by symbiont of host defense response (GO:0052509)3.96821013
15protein localization to chromosome, centromeric region (GO:0071459)3.88346068
16nuclear pore complex assembly (GO:0051292)3.86616918
17antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.85405060
18nuclear pore organization (GO:0006999)3.79382004
19antigen processing and presentation of endogenous antigen (GO:0019883)3.71679041
20regulation of histone H3-K9 methylation (GO:0051570)3.67584844
21negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.61341906
22positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.59614670
23antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.59451634
24mitotic nuclear envelope disassembly (GO:0007077)3.58553645
25mitotic sister chromatid segregation (GO:0000070)3.56940469
26response to peptidoglycan (GO:0032494)3.53278362
27negative regulation of histone methylation (GO:0031061)3.52317103
28sister chromatid segregation (GO:0000819)3.48490636
29antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.47037341
30response to muramyl dipeptide (GO:0032495)3.46081653
31DNA strand elongation involved in DNA replication (GO:0006271)3.45682072
32DNA replication-dependent nucleosome organization (GO:0034723)3.45017797
33DNA replication-dependent nucleosome assembly (GO:0006335)3.45017797
34negative regulation of RNA splicing (GO:0033119)3.44830586
35viral transcription (GO:0019083)3.42660236
36mannose metabolic process (GO:0006013)3.42144697
37regulation of translational fidelity (GO:0006450)3.40870584
38DNA duplex unwinding (GO:0032508)3.40052768
39mitotic chromosome condensation (GO:0007076)3.36811618
40DNA geometric change (GO:0032392)3.36435801
41membrane disassembly (GO:0030397)3.36156520
42nuclear envelope disassembly (GO:0051081)3.36156520
43thymic T cell selection (GO:0045061)3.34993145
44leukocyte aggregation (GO:0070486)3.34130009
45formation of translation preinitiation complex (GO:0001731)3.32578110
46translational termination (GO:0006415)3.32243347
47detection of bacterium (GO:0016045)3.31744344
48regulation of gene silencing by RNA (GO:0060966)3.28146661
49regulation of posttranscriptional gene silencing (GO:0060147)3.28146661
50regulation of gene silencing by miRNA (GO:0060964)3.28146661
51detection of other organism (GO:0098543)3.27741929
52DNA strand elongation (GO:0022616)3.24902830
53chromatin assembly (GO:0031497)3.24498940
54translesion synthesis (GO:0019985)3.20966818
55apoptotic process involved in morphogenesis (GO:0060561)3.20254371
56regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.19454537
57folic acid-containing compound biosynthetic process (GO:0009396)3.17795860
58nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.17297010
59pore complex assembly (GO:0046931)3.17025059
60regulation of gamma-delta T cell activation (GO:0046643)3.16570690
61regulation of sister chromatid cohesion (GO:0007063)3.15667639
62NIK/NF-kappaB signaling (GO:0038061)3.14866678
63nucleosome disassembly (GO:0006337)3.14373491
64protein-DNA complex disassembly (GO:0032986)3.14373491
65mitotic sister chromatid cohesion (GO:0007064)3.12949294
66DNA replication initiation (GO:0006270)3.12078466
67negative regulation of mRNA processing (GO:0050686)3.10979941
68modulation by virus of host process (GO:0019054)3.09583122
69chromosome condensation (GO:0030261)3.09311550
70telomere maintenance via semi-conservative replication (GO:0032201)3.06832551
71mRNA stabilization (GO:0048255)3.06525013
72RNA stabilization (GO:0043489)3.06525013
73translational elongation (GO:0006414)3.05790025
74gene silencing by RNA (GO:0031047)3.05637737
75intracellular estrogen receptor signaling pathway (GO:0030520)3.03226901
76dosage compensation (GO:0007549)3.01345673
77translational initiation (GO:0006413)2.98477365
78regulation of gamma-delta T cell differentiation (GO:0045586)2.98356564
79ribosomal small subunit assembly (GO:0000028)2.97838611
80positive regulation of Cdc42 GTPase activity (GO:0043089)2.97785427
81DNA conformation change (GO:0071103)2.97409277
82positive regulation of chromosome segregation (GO:0051984)2.97365182
83modulation by symbiont of host cellular process (GO:0044068)2.96370410
84gene silencing (GO:0016458)2.95892363
85regulation of RNA export from nucleus (GO:0046831)2.93952172
86spliceosomal tri-snRNP complex assembly (GO:0000244)2.92442541
87maturation of SSU-rRNA (GO:0030490)2.91957620
88protein localization to chromosome (GO:0034502)2.90940749
89regulation of type I interferon-mediated signaling pathway (GO:0060338)2.89933788
90negative regulation of mRNA metabolic process (GO:1903312)2.89679243
91chromatin assembly or disassembly (GO:0006333)2.89040512
92response to laminar fluid shear stress (GO:0034616)2.88737281
93termination of RNA polymerase II transcription (GO:0006369)2.87811435
94positive thymic T cell selection (GO:0045059)2.87276772
95macrophage activation involved in immune response (GO:0002281)2.86237725
96peptidyl-arginine omega-N-methylation (GO:0035247)2.85676735
97trophectodermal cell differentiation (GO:0001829)2.85399158
98germinal center formation (GO:0002467)2.83743340
99pentose-phosphate shunt (GO:0006098)2.83618062
100negative regulation of phagocytosis (GO:0050765)2.83607616
101regulation of chromatin binding (GO:0035561)2.83249779
102T cell selection (GO:0045058)2.83236779
103regulation of mammary gland epithelial cell proliferation (GO:0033599)2.83122089
104regulation of histone H3-K27 methylation (GO:0061085)2.82776292
105nuclear envelope organization (GO:0006998)2.81663842
106DNA packaging (GO:0006323)2.81228739
107histone H3-K36 demethylation (GO:0070544)2.81188620
108positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.81124403
109chromatin silencing (GO:0006342)2.80431203
110protein localization to endosome (GO:0036010)2.80325884
111protein complex disassembly (GO:0043241)2.80037879
1123-UTR-mediated mRNA stabilization (GO:0070935)2.78950095
113mitotic recombination (GO:0006312)2.78934100
114ATP-dependent chromatin remodeling (GO:0043044)2.77494634
115telomere maintenance via recombination (GO:0000722)2.77149136
116histone H4-K12 acetylation (GO:0043983)2.77099862
117ribosomal small subunit biogenesis (GO:0042274)2.76631173
118neutrophil activation involved in immune response (GO:0002283)2.75748841
119embryonic process involved in female pregnancy (GO:0060136)2.75534690
120regulation of leukocyte degranulation (GO:0043300)2.75219088
121negative thymic T cell selection (GO:0045060)2.74488891
122negative regulation of gene expression, epigenetic (GO:0045814)2.74053751
123positive regulation of mitotic sister chromatid separation (GO:1901970)2.73458680
124positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.73458680
125positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.73458680
126meiotic chromosome segregation (GO:0045132)2.72356822
127regulation of protein heterodimerization activity (GO:0043497)2.72090869
128B cell receptor signaling pathway (GO:0050853)2.71489296
129mRNA splicing, via spliceosome (GO:0000398)2.71351632
130RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.71351632
131cellular protein complex disassembly (GO:0043624)2.71201435
132nucleotide-excision repair, DNA gap filling (GO:0006297)2.70827133
133nucleobase biosynthetic process (GO:0046112)2.69825929
134regulation of NFAT protein import into nucleus (GO:0051532)2.69360422
135ncRNA 3-end processing (GO:0043628)2.67642308
136activation of Rac GTPase activity (GO:0032863)2.66421955
137RNA splicing, via transesterification reactions (GO:0000375)2.66415473
138mitotic G1 DNA damage checkpoint (GO:0031571)2.64205837
139regulation of chromosome segregation (GO:0051983)2.63723342
140histone arginine methylation (GO:0034969)2.62643316
141antigen processing and presentation via MHC class Ib (GO:0002475)2.61585808
142positive regulation of B cell differentiation (GO:0045579)2.61064134
143regulation of mast cell degranulation (GO:0043304)2.60647181
144viral life cycle (GO:0019058)2.60571238
145mitotic metaphase plate congression (GO:0007080)2.60483490
146DNA topological change (GO:0006265)2.60306278
147kinetochore organization (GO:0051383)2.59636491
148positive T cell selection (GO:0043368)2.59269747
149regulation of interferon-beta biosynthetic process (GO:0045357)2.58539359
150cellular response to virus (GO:0098586)2.58032119
151synaptonemal complex assembly (GO:0007130)2.57807701
152nuclear-transcribed mRNA catabolic process (GO:0000956)2.57698328
153mRNA cleavage (GO:0006379)2.57597348
154base-excision repair (GO:0006284)2.57114343
155regulation of defense response to virus by virus (GO:0050690)2.57089259
156IMP biosynthetic process (GO:0006188)2.56694016
157negative T cell selection (GO:0043383)2.56340003
158detection of external biotic stimulus (GO:0098581)2.56167318
159regulation of myeloid leukocyte mediated immunity (GO:0002886)2.55799264
160regulation of B cell receptor signaling pathway (GO:0050855)2.55523943
161cell-substrate adherens junction assembly (GO:0007045)2.55521323
162focal adhesion assembly (GO:0048041)2.55521323
163epithelial cell differentiation involved in prostate gland development (GO:0060742)2.54864589
164positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.53883172
165immunoglobulin mediated immune response (GO:0016064)2.52529619
166adherens junction assembly (GO:0034333)2.52432227
167tolerance induction (GO:0002507)2.52199706
168response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.52172651
169response to host (GO:0075136)2.52172651
170response to host defenses (GO:0052200)2.52172651
171pinocytosis (GO:0006907)2.51810132
172histone H4 deacetylation (GO:0070933)2.51455298
173negative regulation of toll-like receptor signaling pathway (GO:0034122)2.51368603
174response to host immune response (GO:0052572)2.50788101
175response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.50788101
176negative regulation of interleukin-12 production (GO:0032695)2.50536429
177respiratory burst (GO:0045730)2.50308825
178negative regulation of cell size (GO:0045792)2.48385558
179maternal placenta development (GO:0001893)2.46958007
180regulation of early endosome to late endosome transport (GO:2000641)2.45674961
181positive regulation of histone deacetylation (GO:0031065)2.42707439
182negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.41857735
183regulation of ARF GTPase activity (GO:0032312)2.40071561
184cellular response to interleukin-4 (GO:0071353)2.39538491
185lipopolysaccharide-mediated signaling pathway (GO:0031663)2.39511696
186regulation of necroptotic process (GO:0060544)2.39369743
187negative regulation of viral release from host cell (GO:1902187)2.39283633
188stress fiber assembly (GO:0043149)2.39157140
189Peyers patch development (GO:0048541)2.39081799

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.74028598
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.68235888
3MYC_22102868_ChIP-Seq_BL_Human3.28684370
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.06996449
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.99858282
6E2F4_17652178_ChIP-ChIP_JURKAT_Human2.99596908
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.95855464
8MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.83648205
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.71501184
10MYC_19079543_ChIP-ChIP_MESCs_Mouse2.59874472
11VDR_21846776_ChIP-Seq_THP-1_Human2.33308092
12NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.24026653
13THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.12386356
14CIITA_25753668_ChIP-Seq_RAJI_Human2.00732690
15XRN2_22483619_ChIP-Seq_HELA_Human2.00184848
16MYC_19030024_ChIP-ChIP_MESCs_Mouse1.99602142
17SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.94198265
18MYC_18358816_ChIP-ChIP_MESCs_Mouse1.87942998
19RACK7_27058665_Chip-Seq_MCF-7_Human1.85959220
20NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.83175958
21TP63_17297297_ChIP-ChIP_HaCaT_Human1.81544617
22E2F1_21310950_ChIP-Seq_MCF-7_Human1.79733739
23TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.77090570
24TCF7_22412390_ChIP-Seq_EML_Mouse1.76206464
25STAT6_21828071_ChIP-Seq_BEAS2B_Human1.75197888
26NELFA_20434984_ChIP-Seq_ESCs_Mouse1.63208127
27UTX_26944678_Chip-Seq_JUKART_Human1.60537066
28ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.60285017
29MAF_26560356_Chip-Seq_TH1_Human1.58529149
30RARG_19884340_ChIP-ChIP_MEFs_Mouse1.57008299
31* KDM2B_26808549_Chip-Seq_DND41_Human1.56696015
32KDM2B_26808549_Chip-Seq_JURKAT_Human1.56044407
33TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.55436246
34POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.54502377
35KDM2B_26808549_Chip-Seq_K562_Human1.53810537
36KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.53031496
37MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.52153071
38MYCN_18555785_ChIP-Seq_MESCs_Mouse1.52100749
39ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.51528864
40* P68_20966046_ChIP-Seq_HELA_Human1.50698935
41KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.49127126
42CTCF_27219007_Chip-Seq_ERYTHROID_Human1.48849490
43DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.48793386
44ETS1_20019798_ChIP-Seq_JURKAT_Human1.46158068
45RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.45419604
46CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.44062785
47KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.43870108
48KDM5A_27292631_Chip-Seq_BREAST_Human1.43584384
49TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.43519626
50KLF4_18555785_ChIP-Seq_MESCs_Mouse1.42581661
51SA1_27219007_Chip-Seq_ERYTHROID_Human1.42576077
52NANOG_18555785_ChIP-Seq_MESCs_Mouse1.41045006
53STAT3_1855785_ChIP-Seq_MESCs_Mouse1.41038161
54* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.40778523
55TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.40457953
56KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.39824088
57SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.37943570
58TP63_19390658_ChIP-ChIP_HaCaT_Human1.36552297
59TET1_21451524_ChIP-Seq_MESCs_Mouse1.36394002
60NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.34433611
61GATA1_22383799_ChIP-Seq_G1ME_Mouse1.33490453
62SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.31666247
63HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.31584700
64MAF_26560356_Chip-Seq_TH2_Human1.31015414
65ELK3_25401928_ChIP-Seq_HUVEC_Human1.30610776
66SCL_19346495_ChIP-Seq_HPC-7_Human1.29953733
67MYB_26560356_Chip-Seq_TH2_Human1.28730767
68EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.28542055
69SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.28349112
70TTF2_22483619_ChIP-Seq_HELA_Human1.28218572
71MYB_26560356_Chip-Seq_TH1_Human1.27914147
72VDR_23849224_ChIP-Seq_CD4+_Human1.27576270
73FOXP3_21729870_ChIP-Seq_TREG_Human1.25037972
74* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.24713499
75KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.24248859
76GABP_19822575_ChIP-Seq_HepG2_Human1.24036482
77MYB_21317192_ChIP-Seq_ERMYB_Mouse1.23810535
78UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.23325383
79STAT4_19710469_ChIP-ChIP_TH1__Mouse1.22709938
80VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.22410994
81EST1_17652178_ChIP-ChIP_JURKAT_Human1.22105705
82IRF8_22096565_ChIP-ChIP_GC-B_Human1.22099148
83POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.21832562
84AR_21909140_ChIP-Seq_LNCAP_Human1.21584605
85SOX2_18555785_ChIP-Seq_MESCs_Mouse1.18994796
86SMC4_20622854_ChIP-Seq_HELA_Human1.18593380
87YY1_21170310_ChIP-Seq_MESCs_Mouse1.18449445
88SPI1_23127762_ChIP-Seq_K562_Human1.18024568
89KDM2B_26808549_Chip-Seq_SUP-B15_Human1.16983777
90P300_27058665_Chip-Seq_ZR-75-30cells_Human1.16628683
91BP1_19119308_ChIP-ChIP_Hs578T_Human1.16171468
92CREB1_15753290_ChIP-ChIP_HEK293T_Human1.16120235
93* RUNX1_22412390_ChIP-Seq_EML_Mouse1.15898393
94CREB1_26743006_Chip-Seq_LNCaP_Human1.15854489
95ZFX_18555785_ChIP-Seq_MESCs_Mouse1.14926925
96DCP1A_22483619_ChIP-Seq_HELA_Human1.14086782
97* BCOR_27268052_Chip-Seq_Bcells_Human1.13941393
98NANOG_21062744_ChIP-ChIP_HESCs_Human1.13306470
99* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12985329
100MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.12590321
101THAP11_20581084_ChIP-Seq_MESCs_Mouse1.12257183
102VDR_24763502_ChIP-Seq_THP-1_Human1.11009190
103PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.11002546
104RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.10947148
105GATA1_19941827_ChIP-Seq_MEL_Mouse1.10797523
106* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.10761116
107JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.09952143
108ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.09133406
109ZFP281_18757296_ChIP-ChIP_E14_Mouse1.08802290
110BCL6_27268052_Chip-Seq_Bcells_Human1.08483215
111CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.07917246
112ZFP281_27345836_Chip-Seq_ESCs_Mouse1.07661824
113SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.07247110
114ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.06221343
115CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.06207421
116TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05094056
117ZNF263_19887448_ChIP-Seq_K562_Human1.04750631
118SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.04145831
119FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.03516815
120* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01988810
121* LXR_22292898_ChIP-Seq_THP-1_Human1.01402981
122E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.01039978
123GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00810566
124E2F1_18555785_ChIP-Seq_MESCs_Mouse1.00573498
125CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.00570111
126SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.00529235
127ATF3_27146783_Chip-Seq_COLON_Human1.00130053
128* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.99318812
129GATA2_22383799_ChIP-Seq_G1ME_Mouse0.98993179
130BRD4_27068464_Chip-Seq_AML-cells_Mouse0.98215585
131SRY_22984422_ChIP-ChIP_TESTIS_Rat0.97818021
132NCOR1_26117541_ChIP-Seq_K562_Human0.97755251
133STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.97521265
134TFEB_21752829_ChIP-Seq_HELA_Human0.96998221
135E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.95372674
136KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.94741804
137SPI1_23547873_ChIP-Seq_NB4_Human0.92534508
138FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.92361632
139DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.91192344
140* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.89543152
141MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.88936223
142KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.88840351
143ELF1_20517297_ChIP-Seq_JURKAT_Human0.88222289
144FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.87803540
145KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.87789526
146KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.87789526
147KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.87789526
148NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.87585674

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003111_abnormal_nucleus_morphology3.65407946
2MP0010094_abnormal_chromosome_stability3.50309222
3MP0003693_abnormal_embryo_hatching3.30285024
4MP0004957_abnormal_blastocyst_morpholog3.27420555
5MP0008057_abnormal_DNA_replication3.27139370
6MP0003077_abnormal_cell_cycle3.10961124
7MP0005451_abnormal_body_composition2.74554524
8MP0010352_gastrointestinal_tract_polyps2.69684248
9MP0008260_abnormal_autophagy2.52834383
10MP0009278_abnormal_bone_marrow2.49975074
11MP0005076_abnormal_cell_differentiation2.33288029
12MP0003763_abnormal_thymus_physiology2.33019234
13MP0008877_abnormal_DNA_methylation2.32806222
14MP0001730_embryonic_growth_arrest2.25860557
15MP0005058_abnormal_lysosome_morphology2.24460462
16MP0004808_abnormal_hematopoietic_stem2.05667639
17MP0000350_abnormal_cell_proliferation2.05458368
18MP0002396_abnormal_hematopoietic_system2.01331015
19MP0010307_abnormal_tumor_latency1.99470922
20MP0004185_abnormal_adipocyte_glucose1.96966655
21MP0003172_abnormal_lysosome_physiology1.95744405
22MP0008058_abnormal_DNA_repair1.95039961
23MP0000703_abnormal_thymus_morphology1.93556812
24MP0008007_abnormal_cellular_replicative1.89697380
25MP0004947_skin_inflammation1.88267172
26MP0002419_abnormal_innate_immunity1.86212170
27MP0005000_abnormal_immune_tolerance1.83687726
28MP0005025_abnormal_response_to1.83506716
29MP0002653_abnormal_ependyma_morphology1.82150568
30MP0004858_abnormal_nervous_system1.80752915
31MP0002398_abnormal_bone_marrow1.75504054
32MP0001697_abnormal_embryo_size1.74245367
33MP0002877_abnormal_melanocyte_morpholog1.73565372
34MP0005380_embryogenesis_phenotype1.73414244
35MP0001672_abnormal_embryogenesis/_devel1.73414244
36MP0002084_abnormal_developmental_patter1.71370086
37MP0002085_abnormal_embryonic_tissue1.70368311
38MP0008932_abnormal_embryonic_tissue1.69842484
39MP0004197_abnormal_fetal_growth/weight/1.69501675
40MP0003705_abnormal_hypodermis_morpholog1.63923109
41MP0002086_abnormal_extraembryonic_tissu1.63205446
42MP0009333_abnormal_splenocyte_physiolog1.60196078
43MP0000490_abnormal_crypts_of1.60187987
44MP0003984_embryonic_growth_retardation1.58838005
45MP0005410_abnormal_fertilization1.58730610
46MP0002080_prenatal_lethality1.57397548
47MP0002088_abnormal_embryonic_growth/wei1.56347881
48MP0000685_abnormal_immune_system1.55836073
49MP0001545_abnormal_hematopoietic_system1.54721569
50MP0005397_hematopoietic_system_phenotyp1.54721569
51MP0003303_peritoneal_inflammation1.54095098
52MP0003191_abnormal_cellular_cholesterol1.52063462
53MP0005464_abnormal_platelet_physiology1.51713888
54MP0003724_increased_susceptibility_to1.50241247
55MP0002722_abnormal_immune_system1.48677657
56MP0003453_abnormal_keratinocyte_physiol1.46949213
57MP0003123_paternal_imprinting1.46574046
58MP0000537_abnormal_urethra_morphology1.46302713
59MP0002019_abnormal_tumor_incidence1.41879152
60MP0000313_abnormal_cell_death1.40416800
61MP0001929_abnormal_gametogenesis1.37468950
62MP0000678_abnormal_parathyroid_gland1.36510837
63MP0000689_abnormal_spleen_morphology1.34496216
64MP0001800_abnormal_humoral_immune1.32481877
65MP0002210_abnormal_sex_determination1.30379758
66MP0003091_abnormal_cell_migration1.29304030
67MP0001849_ear_inflammation1.28306081
68MP0001533_abnormal_skeleton_physiology1.26830713
69MP0001293_anophthalmia1.26629841
70MP0003119_abnormal_digestive_system1.25271797
71MP0009840_abnormal_foam_cell1.24186997
72MP0005666_abnormal_adipose_tissue1.23804021
73MP0000716_abnormal_immune_system1.23765392
74MP0002254_reproductive_system_inflammat1.23154122
75MP0003786_premature_aging1.22215502
76MP0003567_abnormal_fetal_cardiomyocyte1.20920103
77MP0004381_abnormal_hair_follicle1.20850220
78MP0002429_abnormal_blood_cell1.20553117
79MP0002405_respiratory_system_inflammati1.20346080
80MP0003566_abnormal_cell_adhesion1.20316641
81MP0001145_abnormal_male_reproductive1.17904129
82MP0004510_myositis1.16743563
83MP0002420_abnormal_adaptive_immunity1.13663126
84MP0009785_altered_susceptibility_to1.13358358
85MP0001819_abnormal_immune_cell1.11892817
86MP0003121_genomic_imprinting1.11612311
87MP0002796_impaired_skin_barrier1.11434313
88MP0003890_abnormal_embryonic-extraembry1.11398149
89MP0010030_abnormal_orbit_morphology1.08869865
90MP0002998_abnormal_bone_remodeling1.07751685
91MP0003698_abnormal_male_reproductive1.06578084
92MP0003828_pulmonary_edema1.05272262
93MP0005375_adipose_tissue_phenotype1.03730695
94MP0002452_abnormal_antigen_presenting1.02928483
95MP0000733_abnormal_muscle_development1.01440079
96MP0008770_decreased_survivor_rate0.98633050
97MP0005409_darkened_coat_color0.98614575
98MP0004233_abnormal_muscle_weight0.98463970
99MP0002148_abnormal_hypersensitivity_rea0.97903057
100MP0003866_abnormal_defecation0.95637095
101MP0000858_altered_metastatic_potential0.95595743
102MP0002723_abnormal_immune_serum0.95347058
103MP0005623_abnormal_meninges_morphology0.94411650
104MP0002132_abnormal_respiratory_system0.94333501
105MP0005501_abnormal_skin_physiology0.93926568
106MP0001853_heart_inflammation0.93592679
107MP0001845_abnormal_inflammatory_respons0.92882769
108MP0002249_abnormal_larynx_morphology0.92694568
109MP0001851_eye_inflammation0.91923555
110MP0010155_abnormal_intestine_physiology0.91541989
111MP0001873_stomach_inflammation0.91358455
112MP0003315_abnormal_perineum_morphology0.90679280
113MP0000003_abnormal_adipose_tissue0.89940539
114MP0001790_abnormal_immune_system0.89625158
115MP0005387_immune_system_phenotype0.89625158
116MP0009703_decreased_birth_body0.89437583
117MP0005671_abnormal_response_to0.89377088
118MP0002089_abnormal_postnatal_growth/wei0.88940316
119MP0009672_abnormal_birth_weight0.87907170
120MP0000653_abnormal_sex_gland0.87419278
121MP0006082_CNS_inflammation0.86799477
122MP0003861_abnormal_nervous_system0.86574960
123MP0005174_abnormal_tail_pigmentation0.86239835
124MP0002092_abnormal_eye_morphology0.85682275
125MP0003448_altered_tumor_morphology0.85678333
126MP0009931_abnormal_skin_appearance0.84440079
127MP0003183_abnormal_peptide_metabolism0.83507672
128MP0002925_abnormal_cardiovascular_devel0.83333715
129MP0000477_abnormal_intestine_morphology0.83167296
130MP0001915_intracranial_hemorrhage0.82912133
131MP0003115_abnormal_respiratory_system0.81722292
132MP0003436_decreased_susceptibility_to0.81703719
133MP0003300_gastrointestinal_ulcer0.81429711
134MP0000428_abnormal_craniofacial_morphol0.81423163
135MP0009053_abnormal_anal_canal0.81331132
136MP0010234_abnormal_vibrissa_follicle0.80582456
137MP0004264_abnormal_extraembryonic_tissu0.79321571
138MP0005023_abnormal_wound_healing0.79125593
139MP0001348_abnormal_lacrimal_gland0.79091097
140MP0002697_abnormal_eye_size0.78438592
141MP0000465_gastrointestinal_hemorrhage0.77444467
142MP0005310_abnormal_salivary_gland0.76746705
143MP0008961_abnormal_basal_metabolism0.76410243
144MP0001835_abnormal_antigen_presentation0.76308438
145MP0002166_altered_tumor_susceptibility0.75942267
146MP0005621_abnormal_cell_physiology0.75548880
147MP0002009_preneoplasia0.74337700
148MP0008469_abnormal_protein_level0.73722604

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.18264022
2Hyperacusis (HP:0010780)3.60508707
3Nasal polyposis (HP:0100582)3.41630642
4Ependymoma (HP:0002888)3.35249098
5Recurrent abscess formation (HP:0002722)3.17112129
6Cellulitis (HP:0100658)3.15947259
7Selective tooth agenesis (HP:0001592)3.13215438
8Recurrent bacterial skin infections (HP:0005406)3.10160014
9Abnormality of macrophages (HP:0004311)3.03397400
10Basal cell carcinoma (HP:0002671)3.03326686
11Medulloblastoma (HP:0002885)3.02797174
12Increased nuchal translucency (HP:0010880)2.87570741
13Increased IgE level (HP:0003212)2.86951885
14Reticulocytopenia (HP:0001896)2.82163413
15Short 4th metacarpal (HP:0010044)2.79367629
16Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.79367629
17Obstructive lung disease (HP:0006536)2.73600735
18Chronic obstructive pulmonary disease (HP:0006510)2.73600735
19Abnormality of the fingertips (HP:0001211)2.70793972
20Abnormality of the nasal mucosa (HP:0000433)2.69829113
21T lymphocytopenia (HP:0005403)2.69670717
22Renal duplication (HP:0000075)2.64954335
23Broad face (HP:0000283)2.61979742
24Abnormality of the astrocytes (HP:0100707)2.61476732
25Astrocytoma (HP:0009592)2.61476732
26Recurrent bronchitis (HP:0002837)2.59057439
27Proximal placement of thumb (HP:0009623)2.57228640
28Metaphyseal cupping (HP:0003021)2.56013355
29Obstructive sleep apnea (HP:0002870)2.53808231
30Abnormality of cells of the erythroid lineage (HP:0012130)2.52627101
31Deviation of the thumb (HP:0009603)2.51886734
32Gastrointestinal inflammation (HP:0004386)2.50207000
33Colitis (HP:0002583)2.47587092
34Rhabdomyosarcoma (HP:0002859)2.47144228
35Abnormality of T cell number (HP:0011839)2.46363210
36Heterotopia (HP:0002282)2.43178382
37Centrally nucleated skeletal muscle fibers (HP:0003687)2.42872342
38Long palpebral fissure (HP:0000637)2.41778757
39Abnormal number of incisors (HP:0011064)2.40125047
40Disproportionate tall stature (HP:0001519)2.39397694
41Abnormal number of erythroid precursors (HP:0012131)2.39330572
42Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.38501123
43Neoplasm of striated muscle (HP:0009728)2.37712099
44Mediastinal lymphadenopathy (HP:0100721)2.36031466
45Myositis (HP:0100614)2.35717250
46Renovascular hypertension (HP:0100817)2.35467839
47Overriding aorta (HP:0002623)2.34983957
48Distal lower limb amyotrophy (HP:0008944)2.33869401
49Meningitis (HP:0001287)2.32915445
50Elfin facies (HP:0004428)2.29856684
51Recurrent fungal infections (HP:0002841)2.26474435
52Hypertensive crisis (HP:0100735)2.23069398
53Impulsivity (HP:0100710)2.22563794
54Gingivitis (HP:0000230)2.21837949
55Deep palmar crease (HP:0006191)2.18712427
56Increased connective tissue (HP:0009025)2.17999718
57Gastrointestinal infarctions (HP:0005244)2.17515743
58Abnormality of the lower motor neuron (HP:0002366)2.15834854
59Inflammation of the large intestine (HP:0002037)2.14813304
60Missing ribs (HP:0000921)2.14566285
61Segmental peripheral demyelination/remyelination (HP:0003481)2.13523502
62Patellar aplasia (HP:0006443)2.12801245
63Ulnar bowing (HP:0003031)2.12139662
64Abnormality of T cells (HP:0002843)2.11173364
65Polygenic inheritance (HP:0010982)2.11066945
66Chromosomal breakage induced by crosslinking agents (HP:0003221)2.08774955
67Insomnia (HP:0100785)2.08192788
68Facial hemangioma (HP:0000329)2.06869558
69Abnormality of the carotid arteries (HP:0005344)2.06839490
70Recurrent gram-negative bacterial infections (HP:0005420)2.05139998
71Cafe-au-lait spot (HP:0000957)2.05025896
72Abnormality of the thoracic spine (HP:0100711)2.04788946
73Absent thumb (HP:0009777)2.03599418
74Glioma (HP:0009733)2.03326188
75Prominent nose (HP:0000448)2.01581126
76Slow saccadic eye movements (HP:0000514)2.00864948
77Chromsome breakage (HP:0040012)2.00277702
78Abnormality of the ileum (HP:0001549)2.00115322
79Thin bony cortex (HP:0002753)1.99800788
80Combined immunodeficiency (HP:0005387)1.99448643
81Gastrointestinal stroma tumor (HP:0100723)1.99306174
82Squamous cell carcinoma (HP:0002860)1.98497405
83Colon cancer (HP:0003003)1.98190250
84Abnormality of chromosome stability (HP:0003220)1.98167732
85Aplasia/Hypoplasia of the patella (HP:0006498)1.98113982
86Myelodysplasia (HP:0002863)1.97862336
87High pitched voice (HP:0001620)1.97861565
88Bronchitis (HP:0012387)1.96999251
89Orchitis (HP:0100796)1.96208037
90Increased density of long bones (HP:0006392)1.95814402
91Aplasia/Hypoplasia of the uvula (HP:0010293)1.95481639
92Prolonged bleeding time (HP:0003010)1.95284608
93Meckel diverticulum (HP:0002245)1.94788654
94Volvulus (HP:0002580)1.94276629
95Spontaneous hematomas (HP:0007420)1.94012959
96Recurrent skin infections (HP:0001581)1.93618511
97Gastrointestinal carcinoma (HP:0002672)1.92971936
98Malignant gastrointestinal tract tumors (HP:0006749)1.92971936
99Amaurosis fugax (HP:0100576)1.92631195
100Pointed chin (HP:0000307)1.91049177
101Thoracic kyphosis (HP:0002942)1.90123698
102Megalocornea (HP:0000485)1.89565010
103Easy fatigability (HP:0003388)1.89339762
104Flat acetabular roof (HP:0003180)1.89219474
105Abnormality of the 4th metacarpal (HP:0010012)1.87255467
106Abnormality of the anterior horn cell (HP:0006802)1.87230553
107Degeneration of anterior horn cells (HP:0002398)1.87230553
108Amyotrophic lateral sclerosis (HP:0007354)1.87226354
109Rib fusion (HP:0000902)1.86784877
110Achilles tendon contracture (HP:0001771)1.86583161
111Broad distal phalanx of finger (HP:0009836)1.86521025
112Spinal cord lesions (HP:0100561)1.86070201
113Syringomyelia (HP:0003396)1.86070201
11411 pairs of ribs (HP:0000878)1.84920797
115Increased cerebral lipofuscin (HP:0011813)1.84680803
116Poikiloderma (HP:0001029)1.84642530
117Chest pain (HP:0100749)1.83899941
118Ectopic kidney (HP:0000086)1.83064298
119Reticulocytosis (HP:0001923)1.82610936
120Aplasia/hypoplasia of the humerus (HP:0006507)1.82175167
121Urticaria (HP:0001025)1.81297119
122Distal lower limb muscle weakness (HP:0009053)1.81017300
123Viral hepatitis (HP:0006562)1.80332801
124Elevated erythrocyte sedimentation rate (HP:0003565)1.80207622
125Annular pancreas (HP:0001734)1.80050162
126Overlapping toe (HP:0001845)1.79967533
127Emphysema (HP:0002097)1.79764683
128Broad palm (HP:0001169)1.79719661
129Flat cornea (HP:0007720)1.79394224
130Tracheoesophageal fistula (HP:0002575)1.78607110
131Abnormal delayed hypersensitivity skin test (HP:0002963)1.78122806
132Thrombocytosis (HP:0001894)1.77314134
133Pallor (HP:0000980)1.77248016
134Abnormality of cells of the lymphoid lineage (HP:0012140)1.76703460
135Osteomyelitis (HP:0002754)1.76699152
136Cerebral aneurysm (HP:0004944)1.76451949
137Biconcave vertebral bodies (HP:0004586)1.76076138
138Neoplasm of the pancreas (HP:0002894)1.76022532
139Recurrent viral infections (HP:0004429)1.75242937
140Bicuspid aortic valve (HP:0001647)1.75133210
141Bowel diverticulosis (HP:0005222)1.75038111
142Short humerus (HP:0005792)1.74894437
143Panhypogammaglobulinemia (HP:0003139)1.74795233
144Lymphopenia (HP:0001888)1.74714893
145Hemorrhage of the eye (HP:0011885)1.73643249
146Abnormal vertebral ossification (HP:0100569)1.73511432
147Genu recurvatum (HP:0002816)1.72821949
148Skin tags (HP:0010609)1.72167668
149Seborrheic dermatitis (HP:0001051)1.72165016
150Myopathic facies (HP:0002058)1.71897746
151Pustule (HP:0200039)1.70826614
152Lymphoma (HP:0002665)1.70803078
153Neoplasm of the oral cavity (HP:0100649)1.70096068
154Vertebral compression fractures (HP:0002953)1.69553408
155Stridor (HP:0010307)1.69126924
156Duodenal stenosis (HP:0100867)1.68845119
157Small intestinal stenosis (HP:0012848)1.68845119
158Agammaglobulinemia (HP:0004432)1.67936193
159Increased variability in muscle fiber diameter (HP:0003557)1.67880751
160Supernumerary ribs (HP:0005815)1.66990101
161Absent radius (HP:0003974)1.66982342
162Long eyelashes (HP:0000527)1.66339094
163Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.66086598
164Chronic mucocutaneous candidiasis (HP:0002728)1.65971980
165Recurrent cutaneous fungal infections (HP:0011370)1.65971980
166Thin ribs (HP:0000883)1.65739772
167Distal upper limb amyotrophy (HP:0007149)1.65714206
168Upper limb amyotrophy (HP:0009129)1.65714206
169Dislocated radial head (HP:0003083)1.65671215
170Fatigue (HP:0012378)1.65194128
171Hypertriglyceridemia (HP:0002155)1.65089356
172Short thumb (HP:0009778)1.64953230
173Abnormality of the calcaneus (HP:0008364)1.64597955
174Supernumerary bones of the axial skeleton (HP:0009144)1.64440125
175Abnormality of the preputium (HP:0100587)1.63688503
176Cholecystitis (HP:0001082)1.63478094
177Abnormal gallbladder physiology (HP:0012438)1.63478094
178Bowel incontinence (HP:0002607)1.63459637
179Verrucae (HP:0200043)1.62845626
180Papilloma (HP:0012740)1.62845626
181Hypochromic anemia (HP:0001931)1.62323899
182Abnormality of skeletal muscle fiber size (HP:0012084)1.62315094
183Difficulty climbing stairs (HP:0003551)1.61932174
184Vasculitis (HP:0002633)1.61182476
185Abnormality of the distal phalanx of the thumb (HP:0009617)1.61029088
186Progressive external ophthalmoplegia (HP:0000590)1.60845888
187Lower limb amyotrophy (HP:0007210)1.60251422
188Neuronal loss in central nervous system (HP:0002529)1.60194266
189Gastrointestinal dysmotility (HP:0002579)1.59024762
190Hepatosplenomegaly (HP:0001433)1.58494548

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K103.88898156
2EEF2K3.71981442
3SMG13.71233545
4PRPF4B3.62047824
5CDK123.53284103
6MAP4K13.26081258
7ICK3.16357973
8NEK23.10874997
9CDC73.00000894
10ERN12.94718109
11PKN22.70237468
12SIK12.40282991
13TRIB32.30197671
14RIPK42.27463786
15BUB11.90419267
16GRK61.89457607
17WEE11.84430306
18STK101.81146258
19IRAK31.73224420
20DYRK31.68621538
21IRAK41.67645450
22CDK41.67517625
23ALK1.63098289
24MAP3K131.56981415
25PASK1.56491207
26TESK21.48734549
27TESK11.39061248
28EPHB11.34448626
29TAOK21.32762518
30RPS6KB21.32351820
31ATR1.32138030
32TTK1.30558568
33SIK31.28044385
34LRRK21.27625986
35CDK71.27363624
36KSR21.25086253
37MAP3K81.23638538
38SIK21.23362533
39TYRO31.22769321
40ZAP701.21575636
41BLK1.21122818
42BRD41.20845034
43TNK21.20829166
44PAK41.18488928
45CHEK11.18087514
46PLK11.16641288
47PIM11.14708707
48MAP3K11.12266162
49MAP3K141.11416206
50MTOR1.09712888
51MAP3K31.07003401
52PRKD31.05365978
53PTK61.04168279
54PDK41.03665439
55PDK31.03665439
56CDK61.03465085
57TXK1.03060376
58NME21.02163048
59NEK11.00786704
60TBK11.00319333
61AURKB0.99755882
62TTN0.99644011
63STK40.95944161
64CDC42BPA0.95204270
65FES0.94523218
66CHEK20.94410817
67SCYL20.93991371
68DYRK1B0.92679957
69JAK30.91735028
70CDK20.89638948
71CLK10.88292115
72BMX0.86094826
73BTK0.81702239
74MAP3K60.81252609
75TLK10.81179631
76TYK20.80996396
77RPS6KA40.79821985
78IRAK20.78816978
79TSSK60.78050299
80ATM0.77260791
81HIPK20.76465818
82PDPK10.75233284
83EPHA20.72683310
84MAP3K110.72125582
85SRPK10.71499327
86RPS6KA20.71414904
87ITK0.71322917
88TAOK10.70475766
89HCK0.67436294
90CSK0.66426167
91BRAF0.65279484
92KDR0.65080750
93FGFR40.64770411
94PDGFRA0.63320352
95MAP2K20.62211885
96MKNK10.62156080
97MAP3K70.62106441
98ARAF0.61907320
99PRKD20.60812596
100RIPK10.59640910
101LCK0.58698307
102PNCK0.58106662
103FGR0.57440892
104CDK10.56629737
105RPS6KA10.55101828
106PDK10.54714705
107CAMK1D0.54411318
108MAPK120.53700520
109PAK20.53260166
110PAK10.53169897
111TGFBR10.52993159
112RPS6KL10.52745776
113RPS6KC10.52745776
114AURKA0.49502747
115ACVR1B0.49486540
116MARK20.49091214
117IKBKE0.48495889
118PRKCI0.48004158
119CDK90.47152486
120FGFR10.45212495
121RET0.44916635
122JAK20.44886290
123RPS6KA60.44384193
124CSNK1D0.43379350
125SYK0.43357107
126LYN0.42860707
127CSNK2A20.42121772
128CAMKK10.41297322
129MARK30.40388923
130STK30.39632618
131MAP2K30.38406459
132PRKDC0.38341333
133MAPKAPK20.36634967
134MKNK20.36422539
135PRKG20.35747326
136MOS0.35675713
137MAPK110.35089393
138PIM20.34596416
139MAPK70.34052575
140CSF1R0.33772071
141JAK10.33652850
142MAPK140.33025086
143FGFR30.32985363
144PDGFRB0.32896784
145CSNK1E0.32035049

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.80061592
2Mismatch repair_Homo sapiens_hsa034303.15331465
3Spliceosome_Homo sapiens_hsa030402.84640504
4Base excision repair_Homo sapiens_hsa034102.63312068
5RNA transport_Homo sapiens_hsa030132.61876967
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.36704245
7mRNA surveillance pathway_Homo sapiens_hsa030152.32965927
8Ribosome_Homo sapiens_hsa030102.26327264
9Cell cycle_Homo sapiens_hsa041102.14646099
10Other glycan degradation_Homo sapiens_hsa005112.10042982
11Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.02293787
12Primary immunodeficiency_Homo sapiens_hsa053402.01626078
13Homologous recombination_Homo sapiens_hsa034401.99912779
14One carbon pool by folate_Homo sapiens_hsa006701.96395264
15Nucleotide excision repair_Homo sapiens_hsa034201.83725742
16Fanconi anemia pathway_Homo sapiens_hsa034601.76884361
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.66777841
18Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.64136432
19Toll-like receptor signaling pathway_Homo sapiens_hsa046201.52658050
20Chronic myeloid leukemia_Homo sapiens_hsa052201.47859703
21Antigen processing and presentation_Homo sapiens_hsa046121.44505065
22p53 signaling pathway_Homo sapiens_hsa041151.37882780
23T cell receptor signaling pathway_Homo sapiens_hsa046601.37497873
24Viral carcinogenesis_Homo sapiens_hsa052031.37360358
25HTLV-I infection_Homo sapiens_hsa051661.30145700
26Notch signaling pathway_Homo sapiens_hsa043301.29894304
27RNA degradation_Homo sapiens_hsa030181.26570645
28B cell receptor signaling pathway_Homo sapiens_hsa046621.26366370
29Herpes simplex infection_Homo sapiens_hsa051681.25597690
30Epstein-Barr virus infection_Homo sapiens_hsa051691.23484004
31Colorectal cancer_Homo sapiens_hsa052101.21084880
32Pyrimidine metabolism_Homo sapiens_hsa002401.19977922
33MicroRNAs in cancer_Homo sapiens_hsa052061.19521048
34Acute myeloid leukemia_Homo sapiens_hsa052211.19012568
35Viral myocarditis_Homo sapiens_hsa054161.17228140
36Tuberculosis_Homo sapiens_hsa051521.16997878
37Small cell lung cancer_Homo sapiens_hsa052221.16279913
38Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.14533897
39Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.10787526
40Systemic lupus erythematosus_Homo sapiens_hsa053221.10427348
41RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.10061259
42Hepatitis C_Homo sapiens_hsa051601.08716332
43mTOR signaling pathway_Homo sapiens_hsa041501.08648924
44RNA polymerase_Homo sapiens_hsa030201.07881246
45Oocyte meiosis_Homo sapiens_hsa041141.07340541
46TNF signaling pathway_Homo sapiens_hsa046681.06759938
47Non-homologous end-joining_Homo sapiens_hsa034501.06032295
48Measles_Homo sapiens_hsa051621.05147824
49Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.04226114
50Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.04181451
51Thyroid cancer_Homo sapiens_hsa052161.02151092
52Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.01330599
53Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.01093395
54Transcriptional misregulation in cancer_Homo sapiens_hsa052021.00518937
55ErbB signaling pathway_Homo sapiens_hsa040121.00241485
56Non-small cell lung cancer_Homo sapiens_hsa052230.98393961
57NF-kappa B signaling pathway_Homo sapiens_hsa040640.97025856
58VEGF signaling pathway_Homo sapiens_hsa043700.95401672
59Prolactin signaling pathway_Homo sapiens_hsa049170.95094192
60Shigellosis_Homo sapiens_hsa051310.93968426
61Insulin signaling pathway_Homo sapiens_hsa049100.93304136
62Apoptosis_Homo sapiens_hsa042100.91805635
63Phospholipase D signaling pathway_Homo sapiens_hsa040720.89268093
64Allograft rejection_Homo sapiens_hsa053300.87546609
65Choline metabolism in cancer_Homo sapiens_hsa052310.87255696
66Malaria_Homo sapiens_hsa051440.87242830
67Lysine degradation_Homo sapiens_hsa003100.86163368
68Hepatitis B_Homo sapiens_hsa051610.86126756
69Prion diseases_Homo sapiens_hsa050200.84831299
70Basal cell carcinoma_Homo sapiens_hsa052170.83471554
71Central carbon metabolism in cancer_Homo sapiens_hsa052300.83014936
72Phosphatidylinositol signaling system_Homo sapiens_hsa040700.82742155
73GnRH signaling pathway_Homo sapiens_hsa049120.82241033
74Salmonella infection_Homo sapiens_hsa051320.82046781
75Sphingolipid signaling pathway_Homo sapiens_hsa040710.81758979
76Endometrial cancer_Homo sapiens_hsa052130.81062005
77Graft-versus-host disease_Homo sapiens_hsa053320.79341210
78Thyroid hormone signaling pathway_Homo sapiens_hsa049190.79093359
79Inositol phosphate metabolism_Homo sapiens_hsa005620.78931729
80Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.78558293
81Endocytosis_Homo sapiens_hsa041440.78207362
82Autoimmune thyroid disease_Homo sapiens_hsa053200.78192253
83Hippo signaling pathway_Homo sapiens_hsa043900.77369365
84Neurotrophin signaling pathway_Homo sapiens_hsa047220.77234385
85Staphylococcus aureus infection_Homo sapiens_hsa051500.77016445
86Proteasome_Homo sapiens_hsa030500.75696643
87Basal transcription factors_Homo sapiens_hsa030220.75390293
88Glycosaminoglycan degradation_Homo sapiens_hsa005310.73056777
89Fructose and mannose metabolism_Homo sapiens_hsa000510.72383622
90Pancreatic cancer_Homo sapiens_hsa052120.72246869
91Toxoplasmosis_Homo sapiens_hsa051450.72047561
92Adherens junction_Homo sapiens_hsa045200.70127029
93Adipocytokine signaling pathway_Homo sapiens_hsa049200.70079768
94Osteoclast differentiation_Homo sapiens_hsa043800.70033869
95Leukocyte transendothelial migration_Homo sapiens_hsa046700.69082586
96Influenza A_Homo sapiens_hsa051640.67596095
97Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.66036240
98Amoebiasis_Homo sapiens_hsa051460.65250214
99Estrogen signaling pathway_Homo sapiens_hsa049150.64354920
100Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.63404920
101Pathways in cancer_Homo sapiens_hsa052000.63209424
102HIF-1 signaling pathway_Homo sapiens_hsa040660.63034068
103Pentose phosphate pathway_Homo sapiens_hsa000300.61667205
104Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.60793255
105Bladder cancer_Homo sapiens_hsa052190.60549841
106Galactose metabolism_Homo sapiens_hsa000520.59410054
107Lysosome_Homo sapiens_hsa041420.59133536
108AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.58979154
109Proteoglycans in cancer_Homo sapiens_hsa052050.58705813
110MAPK signaling pathway_Homo sapiens_hsa040100.57101448
111Hematopoietic cell lineage_Homo sapiens_hsa046400.55802749
112Intestinal immune network for IgA production_Homo sapiens_hsa046720.55414502
113Dorso-ventral axis formation_Homo sapiens_hsa043200.54999129
114Regulation of actin cytoskeleton_Homo sapiens_hsa048100.54295210
115TGF-beta signaling pathway_Homo sapiens_hsa043500.54258569
116Hedgehog signaling pathway_Homo sapiens_hsa043400.53819048
117Prostate cancer_Homo sapiens_hsa052150.53799165
118Jak-STAT signaling pathway_Homo sapiens_hsa046300.53729514
119Legionellosis_Homo sapiens_hsa051340.52897335
120Alcoholism_Homo sapiens_hsa050340.51059986
121Leishmaniasis_Homo sapiens_hsa051400.49736617
122Cyanoamino acid metabolism_Homo sapiens_hsa004600.49607519
123Renal cell carcinoma_Homo sapiens_hsa052110.49124595
124Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.44841577
125Wnt signaling pathway_Homo sapiens_hsa043100.44180583
126Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.43541024
127Platelet activation_Homo sapiens_hsa046110.41878914
128Selenocompound metabolism_Homo sapiens_hsa004500.41149834
129Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41148571
130Chemokine signaling pathway_Homo sapiens_hsa040620.40983342
131Glioma_Homo sapiens_hsa052140.40546575
132FoxO signaling pathway_Homo sapiens_hsa040680.40112610
133NOD-like receptor signaling pathway_Homo sapiens_hsa046210.39635207
134Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.38944123
135Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.38901526

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »