DCAF16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.41475018
2nuclear pore organization (GO:0006999)5.06899730
3DNA double-strand break processing (GO:0000729)4.48548393
4DNA replication checkpoint (GO:0000076)4.39701552
5mitotic sister chromatid cohesion (GO:0007064)4.38956701
6regulation of DNA endoreduplication (GO:0032875)3.95679887
7kinetochore organization (GO:0051383)3.82386283
8pore complex assembly (GO:0046931)3.82173670
9sister chromatid segregation (GO:0000819)3.81481974
10regulation of mitotic spindle organization (GO:0060236)3.77001108
11negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.76768997
12negative regulation of translation, ncRNA-mediated (GO:0040033)3.76768997
13regulation of translation, ncRNA-mediated (GO:0045974)3.76768997
14regulation of centriole replication (GO:0046599)3.71738688
15mitotic sister chromatid segregation (GO:0000070)3.67415056
16chromatin remodeling at centromere (GO:0031055)3.64902878
17mitotic chromosome condensation (GO:0007076)3.63149823
18meiotic chromosome segregation (GO:0045132)3.62081407
19replication fork processing (GO:0031297)3.60908504
20centriole replication (GO:0007099)3.48852976
21negative regulation of DNA-dependent DNA replication (GO:2000104)3.45667205
22somatic diversification of immune receptors via somatic mutation (GO:0002566)3.39482340
23somatic hypermutation of immunoglobulin genes (GO:0016446)3.39482340
24CENP-A containing nucleosome assembly (GO:0034080)3.39199189
25DNA strand elongation involved in DNA replication (GO:0006271)3.33965804
26regulation of spindle organization (GO:0090224)3.33908390
27DNA unwinding involved in DNA replication (GO:0006268)3.31389217
28regulation of nuclear cell cycle DNA replication (GO:0033262)3.30444664
29intra-S DNA damage checkpoint (GO:0031573)3.30208553
30regulation of centrosome cycle (GO:0046605)3.27302997
31regulation of centrosome duplication (GO:0010824)3.25147922
32kinetochore assembly (GO:0051382)3.22885398
33mitotic nuclear envelope disassembly (GO:0007077)3.22527401
34double-strand break repair via nonhomologous end joining (GO:0006303)3.16686722
35non-recombinational repair (GO:0000726)3.16686722
36protein localization to kinetochore (GO:0034501)3.16512827
37DNA strand elongation (GO:0022616)3.14487971
38hindbrain development (GO:0030902)3.14479161
39DNA topological change (GO:0006265)3.11651774
40mitotic recombination (GO:0006312)3.08982855
41monoubiquitinated protein deubiquitination (GO:0035520)3.08543112
42telomere maintenance via semi-conservative replication (GO:0032201)3.06872434
43regulation of mitotic spindle checkpoint (GO:1903504)3.03873061
44regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.03873061
45maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.02992909
46recombinational repair (GO:0000725)3.02308365
47double-strand break repair via homologous recombination (GO:0000724)3.01480825
48histone exchange (GO:0043486)3.01318462
49negative regulation of mRNA processing (GO:0050686)3.00980230
50telomere maintenance via recombination (GO:0000722)2.99660435
51microtubule depolymerization (GO:0007019)2.97064226
52negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.95718672
53histone H2A acetylation (GO:0043968)2.95439452
54spindle checkpoint (GO:0031577)2.95254991
55nuclear envelope disassembly (GO:0051081)2.95201100
56membrane disassembly (GO:0030397)2.95201100
57positive regulation of mRNA processing (GO:0050685)2.94819177
58DNA geometric change (GO:0032392)2.92724155
59DNA duplex unwinding (GO:0032508)2.91078708
60negative regulation of DNA recombination (GO:0045910)2.89883129
61synapsis (GO:0007129)2.88661194
62mitotic spindle checkpoint (GO:0071174)2.87163249
63regulation of RNA export from nucleus (GO:0046831)2.85316457
64protein localization to chromosome, centromeric region (GO:0071459)2.84278003
65DNA packaging (GO:0006323)2.83338130
66negative regulation of mRNA metabolic process (GO:1903312)2.83247470
67pre-miRNA processing (GO:0031054)2.82927746
68heterochromatin organization (GO:0070828)2.82589645
69DNA conformation change (GO:0071103)2.82063716
70DNA replication-independent nucleosome organization (GO:0034724)2.80715222
71DNA replication-independent nucleosome assembly (GO:0006336)2.80715222
72regulation of DNA damage checkpoint (GO:2000001)2.80506975
73negative regulation of RNA splicing (GO:0033119)2.79865339
74negative regulation of chromosome segregation (GO:0051985)2.78446937
75regulation of sister chromatid segregation (GO:0033045)2.77752745
76regulation of mitotic sister chromatid separation (GO:0010965)2.77752745
77regulation of mitotic sister chromatid segregation (GO:0033047)2.77752745
78attachment of spindle microtubules to kinetochore (GO:0008608)2.77454808
79negative regulation of mitotic sister chromatid separation (GO:2000816)2.75871819
80negative regulation of sister chromatid segregation (GO:0033046)2.75871819
81negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.75871819
82negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.75871819
83negative regulation of mitotic sister chromatid segregation (GO:0033048)2.75871819
84protein K6-linked ubiquitination (GO:0085020)2.75771808
85protein K11-linked deubiquitination (GO:0035871)2.74015647
86centrosome organization (GO:0051297)2.73866143
87negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.73702653
88mRNA splice site selection (GO:0006376)2.73678930
89sister chromatid cohesion (GO:0007062)2.72994490
90regulation of sister chromatid cohesion (GO:0007063)2.71084352
91DNA strand renaturation (GO:0000733)2.70436538
92regulation of mitotic metaphase/anaphase transition (GO:0030071)2.69931648
93regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.69931648
94regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.68792345
95positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.68792345
96DNA ligation (GO:0006266)2.68743603
97resolution of meiotic recombination intermediates (GO:0000712)2.67850380
98mitotic spindle assembly checkpoint (GO:0007094)2.67758667
99positive regulation of mRNA metabolic process (GO:1903313)2.66903330
100somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.66426615

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.33976237
2SALL1_21062744_ChIP-ChIP_HESCs_Human4.12498547
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.98830085
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.93360887
5KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.87668958
6MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.85504810
7* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.62502709
8ZNF274_21170338_ChIP-Seq_K562_Hela2.61924053
9RBPJ_22232070_ChIP-Seq_NCS_Mouse2.61484018
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.36774593
11FUS_26573619_Chip-Seq_HEK293_Human2.36133106
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.34423272
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.30807538
14CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.29845000
15EWS_26573619_Chip-Seq_HEK293_Human2.29449996
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.17497349
17IGF1R_20145208_ChIP-Seq_DFB_Human2.14323925
18TP63_19390658_ChIP-ChIP_HaCaT_Human2.10913570
19ELK1_19687146_ChIP-ChIP_HELA_Human2.06191035
20VDR_22108803_ChIP-Seq_LS180_Human2.05688063
21HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.03782786
22EST1_17652178_ChIP-ChIP_JURKAT_Human2.01760621
23PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.97550724
24E2F1_21310950_ChIP-Seq_MCF-7_Human1.96327181
25TAF15_26573619_Chip-Seq_HEK293_Human1.86762585
26* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.84023104
27PADI4_21655091_ChIP-ChIP_MCF-7_Human1.79017788
28YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.72481932
29GBX2_23144817_ChIP-Seq_PC3_Human1.69963842
30GABP_17652178_ChIP-ChIP_JURKAT_Human1.68680044
31VDR_23849224_ChIP-Seq_CD4+_Human1.66902966
32FLI1_27457419_Chip-Seq_LIVER_Mouse1.64936277
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.64263134
34MYC_18940864_ChIP-ChIP_HL60_Human1.60260866
35AR_21909140_ChIP-Seq_LNCAP_Human1.54262758
36NOTCH1_21737748_ChIP-Seq_TLL_Human1.50895182
37CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.49947428
38SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.46396449
39FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.45861317
40MYC_18555785_ChIP-Seq_MESCs_Mouse1.43274430
41POU5F1_16153702_ChIP-ChIP_HESCs_Human1.43168869
42CTBP2_25329375_ChIP-Seq_LNCAP_Human1.40525752
43P300_19829295_ChIP-Seq_ESCs_Human1.38871587
44KDM5A_27292631_Chip-Seq_BREAST_Human1.38015692
45* FOXP3_21729870_ChIP-Seq_TREG_Human1.36782450
46ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.34677772
47MYCN_18555785_ChIP-Seq_MESCs_Mouse1.31134467
48AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.29091566
49MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.26527570
50IRF1_19129219_ChIP-ChIP_H3396_Human1.25012311
51ETS1_20019798_ChIP-Seq_JURKAT_Human1.23466665
52PCGF2_27294783_Chip-Seq_ESCs_Mouse1.22333529
53TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.21547744
54FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.21292080
55MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.20204855
56SOX2_16153702_ChIP-ChIP_HESCs_Human1.18330093
57CREB1_15753290_ChIP-ChIP_HEK293T_Human1.16766241
58MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.16315169
59RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.15637476
60FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.15618080
61MYC_19030024_ChIP-ChIP_MESCs_Mouse1.14877821
62PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.13011972
63CTBP1_25329375_ChIP-Seq_LNCAP_Human1.12954518
64* STAT3_23295773_ChIP-Seq_U87_Human1.11535261
65TTF2_22483619_ChIP-Seq_HELA_Human1.07813744
66CBP_20019798_ChIP-Seq_JUKART_Human1.06002627
67IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.06002627
68TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04804328
69POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04804328
70DCP1A_22483619_ChIP-Seq_HELA_Human1.04737046
71MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.04033448
72SOX9_26525672_Chip-Seq_HEART_Mouse1.03856621
73BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.02192998
74PKCTHETA_26484144_Chip-Seq_BREAST_Human1.02146449
75UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.99919937
76EZH2_27294783_Chip-Seq_NPCs_Mouse0.99411153
77CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.99234688
78TCF4_23295773_ChIP-Seq_U87_Human0.99140117
79SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.98994617
80SMAD4_21799915_ChIP-Seq_A2780_Human0.98682148
81ER_23166858_ChIP-Seq_MCF-7_Human0.97065026
82SUZ12_27294783_Chip-Seq_NPCs_Mouse0.94575018
83FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.94007254
84NANOG_18555785_Chip-Seq_ESCs_Mouse0.93851161
85TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.93693955
86MYC_19079543_ChIP-ChIP_MESCs_Mouse0.92684017
87PCGF2_27294783_Chip-Seq_NPCs_Mouse0.92648406
88OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92398911
89HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.92379929
90PIAS1_25552417_ChIP-Seq_VCAP_Human0.92191290
91E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.90867501
92PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.89476395
93SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.88441792
94HOXB4_20404135_ChIP-ChIP_EML_Mouse0.87888359
95CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.87439695
96NFE2_27457419_Chip-Seq_LIVER_Mouse0.87043563
97SMAD3_21741376_ChIP-Seq_EPCs_Human0.86474760
98NANOG_16153702_ChIP-ChIP_HESCs_Human0.85862616
99AR_21572438_ChIP-Seq_LNCaP_Human0.85053707
100E2F1_18555785_Chip-Seq_ESCs_Mouse0.85021818

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.36250483
2MP0010094_abnormal_chromosome_stability3.56309376
3MP0008058_abnormal_DNA_repair3.09073944
4MP0003111_abnormal_nucleus_morphology3.08687603
5MP0003693_abnormal_embryo_hatching3.07162677
6MP0006292_abnormal_olfactory_placode2.73732887
7MP0003890_abnormal_embryonic-extraembry2.65086527
8MP0003077_abnormal_cell_cycle2.32553961
9MP0008877_abnormal_DNA_methylation2.29793612
10MP0002009_preneoplasia2.19470264
11MP0004957_abnormal_blastocyst_morpholog2.10446988
12MP0009697_abnormal_copulation2.02017621
13MP0006072_abnormal_retinal_apoptosis2.00592559
14MP0000569_abnormal_digit_pigmentation1.97045596
15MP0003121_genomic_imprinting1.92980127
16MP0002938_white_spotting1.90664067
17MP0003787_abnormal_imprinting1.84786143
18MP0003567_abnormal_fetal_cardiomyocyte1.83018282
19MP0001293_anophthalmia1.78647376
20MP0008007_abnormal_cellular_replicative1.72279287
21MP0003937_abnormal_limbs/digits/tail_de1.66467666
22MP0003122_maternal_imprinting1.61749021
23MP0008932_abnormal_embryonic_tissue1.57930379
24MP0002102_abnormal_ear_morphology1.50510003
25MP0001286_abnormal_eye_development1.48755526
26MP0003718_maternal_effect1.46555514
27MP0000631_abnormal_neuroendocrine_gland1.42537684
28MP0002084_abnormal_developmental_patter1.42043108
29MP0004147_increased_porphyrin_level1.40079061
30MP0002160_abnormal_reproductive_system1.34408062
31MP0002234_abnormal_pharynx_morphology1.32471046
32MP0005253_abnormal_eye_physiology1.30309114
33MP0002396_abnormal_hematopoietic_system1.28397541
34MP0005380_embryogenesis_phenotype1.28241211
35MP0001672_abnormal_embryogenesis/_devel1.28241211
36MP0001697_abnormal_embryo_size1.27944061
37MP0005220_abnormal_exocrine_pancreas1.25144066
38MP0003119_abnormal_digestive_system1.23731863
39MP0004808_abnormal_hematopoietic_stem1.21933814
40MP0010307_abnormal_tumor_latency1.21383064
41MP0001529_abnormal_vocalization1.21146342
42MP0002697_abnormal_eye_size1.20622181
43MP0002088_abnormal_embryonic_growth/wei1.19693880
44MP0008995_early_reproductive_senescence1.19289207
45MP0003943_abnormal_hepatobiliary_system1.18484649
46MP0002085_abnormal_embryonic_tissue1.18396146
47MP0003984_embryonic_growth_retardation1.18369018
48MP0005187_abnormal_penis_morphology1.16741911
49MP0000350_abnormal_cell_proliferation1.16118879
50MP0003786_premature_aging1.16081430
51MP0001188_hyperpigmentation1.15185749
52MP0002638_abnormal_pupillary_reflex1.13632818
53MP0003195_calcinosis1.13356855
54MP0001730_embryonic_growth_arrest1.12920191
55MP0009703_decreased_birth_body1.12196809
56MP0001929_abnormal_gametogenesis1.11510436
57MP0000427_abnormal_hair_cycle1.10015619
58MP0003861_abnormal_nervous_system1.09676023
59MP0004197_abnormal_fetal_growth/weight/1.08778712
60MP0001919_abnormal_reproductive_system1.07420933
61MP0005391_vision/eye_phenotype1.06682306
62MP0000647_abnormal_sebaceous_gland1.06164656
63MP0000516_abnormal_urinary_system1.05003338
64MP0005367_renal/urinary_system_phenotyp1.05003338
65MP0005551_abnormal_eye_electrophysiolog1.03932261
66MP0010352_gastrointestinal_tract_polyps1.03480327
67MP0002210_abnormal_sex_determination1.02008835
68MP0001145_abnormal_male_reproductive1.01713066
69MP0000778_abnormal_nervous_system1.01229040
70MP0002751_abnormal_autonomic_nervous1.01064222
71MP0003755_abnormal_palate_morphology1.00943632
72MP0002233_abnormal_nose_morphology1.00861528
73MP0003935_abnormal_craniofacial_develop0.98921111
74MP0000653_abnormal_sex_gland0.97729716
75MP0000428_abnormal_craniofacial_morphol0.97489551
76MP0004043_abnormal_pH_regulation0.96548551
77MP0001727_abnormal_embryo_implantation0.94196450
78MP0004133_heterotaxia0.93958947
79MP0008789_abnormal_olfactory_epithelium0.90075959
80MP0003698_abnormal_male_reproductive0.89745168
81MP0001984_abnormal_olfaction0.85586346
82MP0002080_prenatal_lethality0.85389078
83MP0002086_abnormal_extraembryonic_tissu0.84601612
84MP0002111_abnormal_tail_morphology0.83766374
85MP0006035_abnormal_mitochondrial_morpho0.81858747
86MP0000383_abnormal_hair_follicle0.81236579
87MP0005389_reproductive_system_phenotype0.81068148
88MP0000049_abnormal_middle_ear0.80808207
89MP0009672_abnormal_birth_weight0.80650069
90MP0005394_taste/olfaction_phenotype0.80368735
91MP0005499_abnormal_olfactory_system0.80368735
92MP0002092_abnormal_eye_morphology0.79023290
93MP0003123_paternal_imprinting0.78788827
94MP0002109_abnormal_limb_morphology0.75889898
95MP0001299_abnormal_eye_distance/0.74577246
96MP0000432_abnormal_head_morphology0.74513530
97MP0003385_abnormal_body_wall0.74479577
98MP0003938_abnormal_ear_development0.72664128
99MP0005395_other_phenotype0.71958406
100MP0002095_abnormal_skin_pigmentation0.69591014

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)3.93473477
2Chromsome breakage (HP:0040012)3.92550984
3Ectopic kidney (HP:0000086)3.41692928
4Abnormality of chromosome stability (HP:0003220)3.29086237
5Colon cancer (HP:0003003)3.18673067
6Volvulus (HP:0002580)3.15263217
7Meckel diverticulum (HP:0002245)2.78968401
8Hyperinsulinemic hypoglycemia (HP:0000825)2.75071838
9Abnormality of the ileum (HP:0001549)2.74375362
10Abnormality of the labia minora (HP:0012880)2.71339644
11Aplasia/Hypoplasia of the uvula (HP:0010293)2.67767107
12Birth length less than 3rd percentile (HP:0003561)2.61133870
13Molar tooth sign on MRI (HP:0002419)2.58550735
14Abnormality of midbrain morphology (HP:0002418)2.58550735
15Nephroblastoma (Wilms tumor) (HP:0002667)2.54776245
16Pancreatic cysts (HP:0001737)2.49664708
17Sloping forehead (HP:0000340)2.47508906
18Abnormality of chromosome segregation (HP:0002916)2.45918856
19Myelodysplasia (HP:0002863)2.41648549
20Embryonal renal neoplasm (HP:0011794)2.41199296
21Intestinal atresia (HP:0011100)2.39320824
22Chronic hepatic failure (HP:0100626)2.37170371
23Pancreatic islet-cell hyperplasia (HP:0004510)2.32440954
24Pancreatic fibrosis (HP:0100732)2.31438596
25Abnormality of the preputium (HP:0100587)2.24031967
26Partial agenesis of the corpus callosum (HP:0001338)2.22503652
27Nephronophthisis (HP:0000090)2.20142683
28Duodenal stenosis (HP:0100867)2.16605456
29Small intestinal stenosis (HP:0012848)2.16605456
30Neoplasm of the adrenal cortex (HP:0100641)2.13287129
31Ependymoma (HP:0002888)2.09570004
32High anterior hairline (HP:0009890)2.06477188
33Patellar aplasia (HP:0006443)2.05538274
34Abnormality of the duodenum (HP:0002246)2.04686079
35Abnormal lung lobation (HP:0002101)2.03621137
36Rhabdomyosarcoma (HP:0002859)2.02460661
37Acute lymphatic leukemia (HP:0006721)2.02071794
38Abnormality of the renal medulla (HP:0100957)2.00954807
39Protruding tongue (HP:0010808)1.99673422
40Absent radius (HP:0003974)1.98612166
41True hermaphroditism (HP:0010459)1.97454093
42Aplasia/Hypoplasia of the sternum (HP:0006714)1.96066720
43Hyperventilation (HP:0002883)1.95284976
44Glioma (HP:0009733)1.93426398
45Abnormality of the pancreatic islet cells (HP:0006476)1.93288999
46Abnormality of endocrine pancreas physiology (HP:0012093)1.93288999
47Abnormality of the carotid arteries (HP:0005344)1.91515311
48Clubbing of toes (HP:0100760)1.91228303
49Duplicated collecting system (HP:0000081)1.89905696
50Abnormal hair whorl (HP:0010721)1.88149412
51Triphalangeal thumb (HP:0001199)1.86902395
52Cafe-au-lait spot (HP:0000957)1.84508580
53Preaxial hand polydactyly (HP:0001177)1.84010266
54Abnormality of the renal cortex (HP:0011035)1.83272157
55Cortical dysplasia (HP:0002539)1.83133806
56Drooling (HP:0002307)1.82043638
57Aplasia involving forearm bones (HP:0009822)1.81421647
58Absent forearm bone (HP:0003953)1.81421647
59Acute myeloid leukemia (HP:0004808)1.80751524
60Aplasia/Hypoplasia of the patella (HP:0006498)1.80553435
61Postaxial foot polydactyly (HP:0001830)1.80050128
62Hepatoblastoma (HP:0002884)1.78907614
63Small hand (HP:0200055)1.77654844
64Abnormal number of incisors (HP:0011064)1.77568115
65Abnormality of the pons (HP:0007361)1.77364875
66Gonadotropin excess (HP:0000837)1.76633364
67Fair hair (HP:0002286)1.76467882
68Overlapping toe (HP:0001845)1.75927534
69Medulloblastoma (HP:0002885)1.74859603
70Abnormality of DNA repair (HP:0003254)1.74427350
71Hypoplastic iliac wings (HP:0002866)1.74113227
72Cystic hygroma (HP:0000476)1.74097866
73Hypoplasia of the pons (HP:0012110)1.73625419
74Increased nuchal translucency (HP:0010880)1.73433212
75Gastroesophageal reflux (HP:0002020)1.73307891
76Abnormality of homocysteine metabolism (HP:0010919)1.72869950
77Homocystinuria (HP:0002156)1.72869950
78Heterotopia (HP:0002282)1.71581010
79Dandy-Walker malformation (HP:0001305)1.70501411
80Abnormality of the astrocytes (HP:0100707)1.70280029
81Astrocytoma (HP:0009592)1.70280029
82Anophthalmia (HP:0000528)1.70111851
83Submucous cleft hard palate (HP:0000176)1.69447885
84Limb hypertonia (HP:0002509)1.67946315
85Neoplasm of the oral cavity (HP:0100649)1.65744299
86Sandal gap (HP:0001852)1.63925039
87Abnormality of the metopic suture (HP:0005556)1.61696764
88Bilateral microphthalmos (HP:0007633)1.61260057
89Abnormality of cochlea (HP:0000375)1.61211124
90Obsessive-compulsive behavior (HP:0000722)1.60218826
91Midline defect of the nose (HP:0004122)1.59749235
92Highly arched eyebrow (HP:0002553)1.59412199
93Supernumerary spleens (HP:0009799)1.56841736
94Bifid tongue (HP:0010297)1.56728020
95Prominent nasal bridge (HP:0000426)1.56540960
96Embryonal neoplasm (HP:0002898)1.56324549
97Exotropia (HP:0000577)1.56040313
98Excessive salivation (HP:0003781)1.55719441
99Abnormality of the renal collecting system (HP:0004742)1.54356855
100Tented upper lip vermilion (HP:0010804)1.54135137

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK3.78119906
2CDC73.10805624
3FRK3.07822553
4AKT33.00098377
5MKNK22.75611512
6TTK2.75408318
7BRSK22.72618646
8WEE12.58959108
9PNCK2.50184698
10PLK42.31841918
11MKNK12.23514065
12WNK32.07479913
13BUB12.04673451
14NLK1.99812230
15SRPK11.96020247
16MAP3K101.92024919
17BRD41.81869482
18BMPR1B1.79886851
19NUAK11.76442252
20PLK31.73734447
21ZAK1.67667329
22EIF2AK31.61637543
23MAP3K41.55259361
24CDK91.55149146
25ERBB31.50372079
26PASK1.44634130
27EIF2AK11.39685312
28ATR1.33277276
29EEF2K1.30919941
30VRK11.29166559
31TAF11.25853394
32NEK21.22710474
33FGFR21.17807105
34CHEK21.17415985
35TRIM281.16514792
36GRK11.15035166
37CAMK1G1.11060690
38PLK11.11001540
39ATM1.07258142
40NEK11.07150311
41STK31.06872787
42TSSK61.06493738
43ACVR1B1.05536505
44PLK21.04937236
45CDK121.00822232
46BCR0.93181461
47LATS10.90534973
48WNK40.90160406
49EIF2AK20.87687890
50SGK20.87358428
51BRSK10.84659073
52MELK0.84456053
53CHEK10.83889025
54MAP4K20.81311427
55CDK80.80596798
56MAPK130.80466567
57STK38L0.80454333
58MAPKAPK50.78067627
59CAMK1D0.77896054
60PBK0.70093315
61DYRK20.68948659
62TGFBR10.68459642
63CLK10.68145552
64AURKB0.66766966
65CSNK1G10.63384386
66CDK10.61160624
67CASK0.60999297
68WNK10.58635782
69CDK20.57988448
70CSNK1A1L0.57460888
71FGFR10.56021359
72CSNK1E0.54640509
73DYRK30.52330019
74CDK70.51601963
75YES10.51107593
76INSRR0.51071918
77STK40.50980356
78EPHA30.46927522
79STK390.46530160
80PAK30.46129525
81SGK30.44004987
82VRK20.43957153
83PRKDC0.43602781
84SGK2230.42409757
85SGK4940.42409757
86TEC0.42350624
87BRAF0.41116306
88RPS6KB20.40964898
89PRKCE0.40898880
90MAP2K70.40316692
91RPS6KB10.40301160
92MST40.39925005
93CSNK1G30.39806329
94CSNK1G20.39669673
95CCNB10.39353117
96FLT30.38156246
97PRKAA10.37675939
98CDK40.37066370
99CSNK1D0.36500671
100RPS6KA40.36025892

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034503.85539139
2Fanconi anemia pathway_Homo sapiens_hsa034603.43852675
3DNA replication_Homo sapiens_hsa030303.39656035
4Homologous recombination_Homo sapiens_hsa034403.27416639
5Mismatch repair_Homo sapiens_hsa034303.27086454
6RNA transport_Homo sapiens_hsa030132.64369768
7Cell cycle_Homo sapiens_hsa041102.58498541
8RNA degradation_Homo sapiens_hsa030182.53128796
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.51166120
10One carbon pool by folate_Homo sapiens_hsa006702.46696333
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.42881216
12Nucleotide excision repair_Homo sapiens_hsa034202.38631875
13Basal transcription factors_Homo sapiens_hsa030222.37856418
14Lysine degradation_Homo sapiens_hsa003102.37479301
15Spliceosome_Homo sapiens_hsa030402.21351839
16RNA polymerase_Homo sapiens_hsa030202.09236247
17Selenocompound metabolism_Homo sapiens_hsa004502.04541611
18mRNA surveillance pathway_Homo sapiens_hsa030151.96170731
19Base excision repair_Homo sapiens_hsa034101.92782464
20Protein export_Homo sapiens_hsa030601.81149683
21Maturity onset diabetes of the young_Homo sapiens_hsa049501.57625984
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.50373551
23Basal cell carcinoma_Homo sapiens_hsa052171.42685960
24Propanoate metabolism_Homo sapiens_hsa006401.38811948
25Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.37347865
26Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.32411423
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.17110908
28Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.15610334
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.08654737
30p53 signaling pathway_Homo sapiens_hsa041151.08599876
31Steroid biosynthesis_Homo sapiens_hsa001001.08343715
32Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.07480234
33Colorectal cancer_Homo sapiens_hsa052101.06480249
34Oocyte meiosis_Homo sapiens_hsa041141.06314716
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.04569469
36Hedgehog signaling pathway_Homo sapiens_hsa043401.02171920
37Thyroid cancer_Homo sapiens_hsa052161.01035490
38Hippo signaling pathway_Homo sapiens_hsa043900.99588226
39Pyrimidine metabolism_Homo sapiens_hsa002400.96600421
40Wnt signaling pathway_Homo sapiens_hsa043100.96518942
41Butanoate metabolism_Homo sapiens_hsa006500.95993326
42Cysteine and methionine metabolism_Homo sapiens_hsa002700.95257133
43Nitrogen metabolism_Homo sapiens_hsa009100.94410185
44TGF-beta signaling pathway_Homo sapiens_hsa043500.93247329
45Circadian rhythm_Homo sapiens_hsa047100.93031567
46Purine metabolism_Homo sapiens_hsa002300.91977484
47MicroRNAs in cancer_Homo sapiens_hsa052060.91531231
48Prostate cancer_Homo sapiens_hsa052150.86865360
49Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.82298011
50Alcoholism_Homo sapiens_hsa050340.77498655
51Phototransduction_Homo sapiens_hsa047440.75844610
52Regulation of autophagy_Homo sapiens_hsa041400.72749193
53mTOR signaling pathway_Homo sapiens_hsa041500.72682862
54FoxO signaling pathway_Homo sapiens_hsa040680.67590532
55Adherens junction_Homo sapiens_hsa045200.66572147
56Taste transduction_Homo sapiens_hsa047420.62608603
57Longevity regulating pathway - mammal_Homo sapiens_hsa042110.61378042
58Transcriptional misregulation in cancer_Homo sapiens_hsa052020.57901528
59Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.55765618
60Endometrial cancer_Homo sapiens_hsa052130.52898530
61Ether lipid metabolism_Homo sapiens_hsa005650.50040178
62Viral carcinogenesis_Homo sapiens_hsa052030.49184587
63Thyroid hormone signaling pathway_Homo sapiens_hsa049190.48803118
64Fatty acid biosynthesis_Homo sapiens_hsa000610.48524356
65Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.48187784
66Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.47881357
67Olfactory transduction_Homo sapiens_hsa047400.47473603
68Nicotine addiction_Homo sapiens_hsa050330.46013446
69Peroxisome_Homo sapiens_hsa041460.43716624
70Fatty acid metabolism_Homo sapiens_hsa012120.43341474
71Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41013882
72Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.40702718
73Melanoma_Homo sapiens_hsa052180.40158663
74Thyroid hormone synthesis_Homo sapiens_hsa049180.39741039
75Insulin secretion_Homo sapiens_hsa049110.37300058
76Type II diabetes mellitus_Homo sapiens_hsa049300.35370427
77Systemic lupus erythematosus_Homo sapiens_hsa053220.35333373
78Inositol phosphate metabolism_Homo sapiens_hsa005620.33290242
79Pyruvate metabolism_Homo sapiens_hsa006200.33158152
80Non-small cell lung cancer_Homo sapiens_hsa052230.32911820
81Melanogenesis_Homo sapiens_hsa049160.32300287
82Tight junction_Homo sapiens_hsa045300.32112678
83Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.29714909
84Chronic myeloid leukemia_Homo sapiens_hsa052200.28599313
85Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.28451333
86Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.26957400
87Cocaine addiction_Homo sapiens_hsa050300.25459618
88Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.25170801
89Glucagon signaling pathway_Homo sapiens_hsa049220.24594066
90Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.23879158
91Amphetamine addiction_Homo sapiens_hsa050310.23797305
92Long-term depression_Homo sapiens_hsa047300.23389161
93Dorso-ventral axis formation_Homo sapiens_hsa043200.22721486
94Fatty acid elongation_Homo sapiens_hsa000620.22259101
95Tryptophan metabolism_Homo sapiens_hsa003800.21921790
96N-Glycan biosynthesis_Homo sapiens_hsa005100.21262421
97AMPK signaling pathway_Homo sapiens_hsa041520.19342276
98Pancreatic cancer_Homo sapiens_hsa052120.19186304
99Dopaminergic synapse_Homo sapiens_hsa047280.19163559
100Aldosterone synthesis and secretion_Homo sapiens_hsa049250.18461709

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