DCAF17

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a nuclear transmembrane protein that associates with cullin 4A/damaged DNA binding protein 1 ubiquitin ligase complex. Mutations in this gene are associated with Woodhouse-Sakati syndrome. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)7.10844657
2nuclear pore organization (GO:0006999)6.61046621
3pore complex assembly (GO:0046931)4.92457994
4mitotic sister chromatid cohesion (GO:0007064)4.76346953
5regulation of histone H3-K9 methylation (GO:0051570)4.64770805
6pre-miRNA processing (GO:0031054)4.43976756
7DNA topological change (GO:0006265)4.30555387
8kinetochore organization (GO:0051383)4.03255536
9monoubiquitinated protein deubiquitination (GO:0035520)4.00091967
10DNA deamination (GO:0045006)3.93273558
11kinetochore assembly (GO:0051382)3.90975551
12DNA unwinding involved in DNA replication (GO:0006268)3.90475334
13regulation of centriole replication (GO:0046599)3.85105150
14CENP-A containing nucleosome assembly (GO:0034080)3.83886335
15establishment of integrated proviral latency (GO:0075713)3.75297711
16ribosomal small subunit assembly (GO:0000028)3.73172558
17folic acid-containing compound biosynthetic process (GO:0009396)3.73170165
18chromatin remodeling at centromere (GO:0031055)3.70868777
19protein localization to kinetochore (GO:0034501)3.63001682
20intra-S DNA damage checkpoint (GO:0031573)3.62412246
21telomere maintenance via semi-conservative replication (GO:0032201)3.58264041
22mitotic G2/M transition checkpoint (GO:0044818)3.57883606
23rRNA modification (GO:0000154)3.55971852
24IMP biosynthetic process (GO:0006188)3.53823288
25maturation of SSU-rRNA (GO:0030490)3.53711010
26meiotic chromosome segregation (GO:0045132)3.52156719
27double-strand break repair via nonhomologous end joining (GO:0006303)3.52035374
28non-recombinational repair (GO:0000726)3.52035374
29DNA geometric change (GO:0032392)3.49899132
30proteasome assembly (GO:0043248)3.49843570
31negative regulation of DNA recombination (GO:0045910)3.49630584
32transcription elongation from RNA polymerase III promoter (GO:0006385)3.48795132
33termination of RNA polymerase III transcription (GO:0006386)3.48795132
34protein localization to chromosome, centromeric region (GO:0071459)3.47259780
35DNA duplex unwinding (GO:0032508)3.46506046
36DNA replication initiation (GO:0006270)3.46024043
37negative regulation of histone methylation (GO:0031061)3.45512471
38DNA double-strand break processing (GO:0000729)3.43865434
39regulation of RNA export from nucleus (GO:0046831)3.43122680
40tRNA methylation (GO:0030488)3.42927198
41nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)3.42675183
42IMP metabolic process (GO:0046040)3.42114596
43pseudouridine synthesis (GO:0001522)3.40152990
44deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.38932064
45exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.38522125
46daunorubicin metabolic process (GO:0044597)3.37804810
47polyketide metabolic process (GO:0030638)3.37804810
48doxorubicin metabolic process (GO:0044598)3.37804810
49rRNA methylation (GO:0031167)3.37711552
50regulation of nuclear cell cycle DNA replication (GO:0033262)3.37362041
51mitotic G2 DNA damage checkpoint (GO:0007095)3.37177509
52DNA ligation (GO:0006266)3.37130888
53ribosomal large subunit biogenesis (GO:0042273)3.34708318
54mitotic nuclear envelope disassembly (GO:0007077)3.34171509
55single strand break repair (GO:0000012)3.33393811
56cytoplasmic mRNA processing body assembly (GO:0033962)3.31320681
57DNA strand elongation involved in DNA replication (GO:0006271)3.29375683
58telomere maintenance via recombination (GO:0000722)3.28036570
59nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.27674357
60DNA strand elongation (GO:0022616)3.25164507
61pyrimidine dimer repair (GO:0006290)3.20219060
62negative regulation of DNA repair (GO:0045738)3.18710739
63preassembly of GPI anchor in ER membrane (GO:0016254)3.17842275
64sister chromatid segregation (GO:0000819)3.17734825
65regulation of centrosome cycle (GO:0046605)3.17113898
66transcription elongation from RNA polymerase I promoter (GO:0006362)3.16042992
67termination of RNA polymerase I transcription (GO:0006363)3.15807054
68regulation of histone H3-K27 methylation (GO:0061085)3.15498245
69spliceosomal complex assembly (GO:0000245)3.14994920
70regulation of helicase activity (GO:0051095)3.13325756
71DNA replication-independent nucleosome assembly (GO:0006336)3.12865114
72DNA replication-independent nucleosome organization (GO:0034724)3.12865114
73negative regulation of mitotic sister chromatid separation (GO:2000816)3.12825668
74negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.12825668
75negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.12825668
76negative regulation of chromosome segregation (GO:0051985)3.12441543
77regulation of centrosome duplication (GO:0010824)3.12204491
78ribosomal small subunit biogenesis (GO:0042274)3.12126429
79DNA replication checkpoint (GO:0000076)3.12059997
80telomere maintenance via telomere lengthening (GO:0010833)3.11453601
81isotype switching (GO:0045190)3.11276313
82somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.11276313
83somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.11276313
84nuclear envelope disassembly (GO:0051081)3.10716337
85membrane disassembly (GO:0030397)3.10716337
86regulation of sister chromatid segregation (GO:0033045)3.10014648
87regulation of mitotic sister chromatid separation (GO:0010965)3.10014648
88regulation of mitotic sister chromatid segregation (GO:0033047)3.10014648
89mismatch repair (GO:0006298)3.09793371
90regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.09522821
91regulation of mitotic metaphase/anaphase transition (GO:0030071)3.09522821
92mitotic recombination (GO:0006312)3.09253434
93formation of translation preinitiation complex (GO:0001731)3.08642072
94regulation of Golgi to plasma membrane protein transport (GO:0042996)3.07092519
95mitotic metaphase plate congression (GO:0007080)3.06425656
96mitotic chromosome condensation (GO:0007076)3.04602991
97protein K6-linked ubiquitination (GO:0085020)3.04271397
98mitotic spindle checkpoint (GO:0071174)3.02833431
99ATP-dependent chromatin remodeling (GO:0043044)3.02768358
100regulation of DNA endoreduplication (GO:0032875)3.01845507
101positive regulation of histone methylation (GO:0031062)3.01316936
102histone exchange (GO:0043486)3.00725157
103synapsis (GO:0007129)3.00689691
104establishment of viral latency (GO:0019043)3.00326377
105metaphase plate congression (GO:0051310)2.99640933
106positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.98226954
107positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.98226954
108positive regulation of mitotic sister chromatid separation (GO:1901970)2.98226954
109regulation of sister chromatid cohesion (GO:0007063)2.98092450
110postreplication repair (GO:0006301)2.97838485
111rRNA processing (GO:0006364)2.97333773
112viral mRNA export from host cell nucleus (GO:0046784)2.96972604
113DNA conformation change (GO:0071103)2.95842918
114negative regulation of transcription by competitive promoter binding (GO:0010944)2.95294068
115ribonucleoprotein complex biogenesis (GO:0022613)2.94429184
116spindle checkpoint (GO:0031577)2.94392397
117regulation of chromosome segregation (GO:0051983)2.92239294
118regulation of translational fidelity (GO:0006450)2.92136660
119mitotic spindle assembly checkpoint (GO:0007094)2.91460313
120RNA methylation (GO:0001510)2.91032201
121nucleotide-excision repair, DNA gap filling (GO:0006297)2.90759895
122spindle assembly checkpoint (GO:0071173)2.89320120
123rRNA metabolic process (GO:0016072)2.88434143
124maturation of 5.8S rRNA (GO:0000460)2.88249138
125somatic hypermutation of immunoglobulin genes (GO:0016446)2.87925659
126somatic diversification of immune receptors via somatic mutation (GO:0002566)2.87925659
127sister chromatid cohesion (GO:0007062)2.87518963
128GPI anchor biosynthetic process (GO:0006506)2.87378735
129definitive hemopoiesis (GO:0060216)2.86199152
130negative regulation of DNA-dependent DNA replication (GO:2000104)2.85566233
131somatic diversification of immune receptors (GO:0002200)2.85025472
132tRNA modification (GO:0006400)2.84708553
133spliceosomal snRNP assembly (GO:0000387)2.83997683
134transcription from RNA polymerase I promoter (GO:0006360)2.83932187
135transcription-coupled nucleotide-excision repair (GO:0006283)2.83174810
1367-methylguanosine RNA capping (GO:0009452)2.82642229
137RNA capping (GO:0036260)2.82642229
138DNA synthesis involved in DNA repair (GO:0000731)2.81416740
139mRNA transport (GO:0051028)2.80766785
140somatic recombination of immunoglobulin gene segments (GO:0016447)2.80680430
141maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.80313010
142ncRNA catabolic process (GO:0034661)2.79147439
143telomere organization (GO:0032200)2.78718314
144deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.78407488
145regulation of mitochondrial translation (GO:0070129)2.77985912
146telomere maintenance (GO:0000723)2.77547931
147RNA export from nucleus (GO:0006405)2.77210072
1487-methylguanosine mRNA capping (GO:0006370)2.77015882
149tRNA processing (GO:0008033)2.76094866
150mitotic DNA integrity checkpoint (GO:0044774)2.75638089
151positive regulation of histone H3-K4 methylation (GO:0051571)2.75346656
152mitochondrial DNA replication (GO:0006264)2.75095523
153centriole replication (GO:0007099)2.72278808
154L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.71918685
155ncRNA processing (GO:0034470)2.70511835
156ribosome assembly (GO:0042255)2.69634190
157somatic diversification of immunoglobulins (GO:0016445)2.69430552
158ribosome biogenesis (GO:0042254)2.66832324
159DNA-templated transcription, termination (GO:0006353)2.65338214
160DNA demethylation (GO:0080111)2.64654420
161microtubule depolymerization (GO:0007019)2.63991558
162attachment of spindle microtubules to kinetochore (GO:0008608)2.63548098
163viral transcription (GO:0019083)2.62929201
164transcription initiation from RNA polymerase I promoter (GO:0006361)2.60690020
165somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.60607559
166somatic cell DNA recombination (GO:0016444)2.60607559
167centriole assembly (GO:0098534)2.59721138
168translational termination (GO:0006415)2.58825120
169DNA dealkylation (GO:0035510)2.57792380
170telomere maintenance via telomerase (GO:0007004)2.57344857
171ncRNA metabolic process (GO:0034660)2.57132348
172negative regulation of mitotic sister chromatid segregation (GO:0033048)2.57114785
173negative regulation of sister chromatid segregation (GO:0033046)2.57114785

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.74353083
2E2F4_17652178_ChIP-ChIP_JURKAT_Human3.75363884
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.70366359
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.65185239
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.34919811
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.10389610
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.98884764
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.98767969
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.96325042
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.76050323
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.75590869
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.74962503
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.68561198
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.61691283
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.61538165
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.59439631
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.57194680
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.52206506
19VDR_23849224_ChIP-Seq_CD4+_Human2.40966966
20MYC_19030024_ChIP-ChIP_MESCs_Mouse2.35482781
21MYC_18358816_ChIP-ChIP_MESCs_Mouse2.30501932
22FOXM1_23109430_ChIP-Seq_U2OS_Human2.29071977
23FOXP3_21729870_ChIP-Seq_TREG_Human2.15446351
24GATA1_22025678_ChIP-Seq_K562_Human2.13611592
25NOTCH1_21737748_ChIP-Seq_TLL_Human2.13449326
26MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.12290629
27IRF1_19129219_ChIP-ChIP_H3396_Human2.11696104
28MYC_19079543_ChIP-ChIP_MESCs_Mouse2.11033465
29TAF15_26573619_Chip-Seq_HEK293_Human2.09583510
30* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.04536612
31CREB1_15753290_ChIP-ChIP_HEK293T_Human2.04430990
32MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.02598871
33ELK1_19687146_ChIP-ChIP_HELA_Human1.88810744
34YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.87003174
35SALL1_21062744_ChIP-ChIP_HESCs_Human1.81144168
36SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.78555199
37NELFA_20434984_ChIP-Seq_ESCs_Mouse1.77409770
38PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.74885437
39E2F1_18555785_ChIP-Seq_MESCs_Mouse1.74153185
40SRF_21415370_ChIP-Seq_HL-1_Mouse1.72503709
41MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.69375306
42HOXB4_20404135_ChIP-ChIP_EML_Mouse1.69300994
43EGR1_19374776_ChIP-ChIP_THP-1_Human1.69277154
44THAP11_20581084_ChIP-Seq_MESCs_Mouse1.67592224
45XRN2_22483619_ChIP-Seq_HELA_Human1.66869979
46CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.66824438
47TP63_19390658_ChIP-ChIP_HaCaT_Human1.65616499
48KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.64955440
49DCP1A_22483619_ChIP-Seq_HELA_Human1.62806849
50FLI1_27457419_Chip-Seq_LIVER_Mouse1.59557706
51PCGF2_27294783_Chip-Seq_ESCs_Mouse1.57008333
52TTF2_22483619_ChIP-Seq_HELA_Human1.56817655
53YY1_21170310_ChIP-Seq_MESCs_Mouse1.53995847
54* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.53276790
55SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.52999116
56E2F1_21310950_ChIP-Seq_MCF-7_Human1.52475233
57HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.50921200
58ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.50593116
59FUS_26573619_Chip-Seq_HEK293_Human1.50162782
60PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48431219
61WT1_19549856_ChIP-ChIP_CCG9911_Human1.47179738
62MYCN_18555785_ChIP-Seq_MESCs_Mouse1.46150401
63ZNF274_21170338_ChIP-Seq_K562_Hela1.44208936
64MYC_18940864_ChIP-ChIP_HL60_Human1.41904340
65ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.40716726
66FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.39231981
67SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.38300255
68RBPJ_22232070_ChIP-Seq_NCS_Mouse1.38283185
69EWS_26573619_Chip-Seq_HEK293_Human1.38250479
70* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.36989995
71GABP_19822575_ChIP-Seq_HepG2_Human1.34921126
72POU5F1_16153702_ChIP-ChIP_HESCs_Human1.32584312
73SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.31507770
74PADI4_21655091_ChIP-ChIP_MCF-7_Human1.30281371
75* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.29108449
76ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.26768277
77CIITA_25753668_ChIP-Seq_RAJI_Human1.25633239
78CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.24737542
79NFE2_27457419_Chip-Seq_LIVER_Mouse1.23634107
80POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.22329942
81SUZ12_27294783_Chip-Seq_NPCs_Mouse1.19934885
82NANOG_18555785_ChIP-Seq_MESCs_Mouse1.19482680
83IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.19470557
84EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.19256709
85PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.19096445
86AR_21909140_ChIP-Seq_LNCAP_Human1.17834879
87IGF1R_20145208_ChIP-Seq_DFB_Human1.17508344
88PCGF2_27294783_Chip-Seq_NPCs_Mouse1.17060155
89GBX2_23144817_ChIP-Seq_PC3_Human1.16271092
90FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.14004484
91GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.09327877
92POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.09222180
93ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.06930659
94SOX2_18555785_ChIP-Seq_MESCs_Mouse1.06848266
95TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.06614520
96SOX2_16153702_ChIP-ChIP_HESCs_Human1.05116427
97AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.04975368
98NANOG_16153702_ChIP-ChIP_HESCs_Human1.04148685
99KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.02059167
100KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.02059167
101KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.02059167
102MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.01678338
103* SPI1_23547873_ChIP-Seq_NB4_Human1.01498445
104POU3F2_20337985_ChIP-ChIP_501MEL_Human1.00322513
105GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99020514
106SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.98086729
107P300_19829295_ChIP-Seq_ESCs_Human0.97904909
108VDR_22108803_ChIP-Seq_LS180_Human0.96670269
109RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.96371290
110EZH2_27294783_Chip-Seq_NPCs_Mouse0.96050387
111NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.94680905
112RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.92614414
113KDM5A_27292631_Chip-Seq_BREAST_Human0.92600735
114GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.89405232
115E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.89195443
116ZFP57_27257070_Chip-Seq_ESCs_Mouse0.89060256
117SALL4_22934838_ChIP-ChIP_CD34+_Human0.88500151
118DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.88415923
119OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.87927394
120SUZ12_18555785_Chip-Seq_ESCs_Mouse0.86753621
121* STAT3_23295773_ChIP-Seq_U87_Human0.86662878
122STAT3_18555785_Chip-Seq_ESCs_Mouse0.85989060
123* RUNX1_27457419_Chip-Seq_LIVER_Mouse0.84534008
124CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.84468085
125ZFX_18555785_ChIP-Seq_MESCs_Mouse0.84378109
126NMYC_18555785_Chip-Seq_ESCs_Mouse0.83815365
127SOX17_20123909_ChIP-Seq_XEN_Mouse0.83567921
128TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.83126318
129P300_18555785_Chip-Seq_ESCs_Mouse0.81813653
130SALL4_18804426_ChIP-ChIP_XEN_Mouse0.81342000
131TFEB_21752829_ChIP-Seq_HELA_Human0.81335234
132OCT4_18555785_Chip-Seq_ESCs_Mouse0.81081209
133ZFX_18555785_Chip-Seq_ESCs_Mouse0.79543330
134FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.79282365
135NANOG_18555785_Chip-Seq_ESCs_Mouse0.79241672
136NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.79011346
137* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.76879211

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008058_abnormal_DNA_repair3.72235205
2MP0006292_abnormal_olfactory_placode3.71520776
3MP0010094_abnormal_chromosome_stability3.56406224
4MP0008057_abnormal_DNA_replication3.54754162
5MP0003693_abnormal_embryo_hatching3.17281746
6MP0002009_preneoplasia2.95969667
7MP0003111_abnormal_nucleus_morphology2.91076293
8MP0003077_abnormal_cell_cycle2.59716691
9MP0002277_abnormal_respiratory_mucosa2.40017389
10MP0002396_abnormal_hematopoietic_system2.32359939
11MP0001188_hyperpigmentation2.30717295
12MP0004957_abnormal_blastocyst_morpholog2.25746618
13MP0000566_synostosis2.21597950
14MP0003136_yellow_coat_color2.20657480
15MP0000569_abnormal_digit_pigmentation2.19557534
16MP0008932_abnormal_embryonic_tissue1.99811510
17MP0005409_darkened_coat_color1.95144597
18MP0003567_abnormal_fetal_cardiomyocyte1.95052570
19MP0008007_abnormal_cellular_replicative1.94854156
20MP0005075_abnormal_melanosome_morpholog1.93744250
21MP0002102_abnormal_ear_morphology1.89880891
22MP0002938_white_spotting1.89736913
23MP0008877_abnormal_DNA_methylation1.88935683
24MP0005380_embryogenesis_phenotype1.84010258
25MP0001672_abnormal_embryogenesis/_devel1.84010258
26MP0002132_abnormal_respiratory_system1.82424765
27MP0009697_abnormal_copulation1.79260660
28MP0003984_embryonic_growth_retardation1.78421245
29MP0004381_abnormal_hair_follicle1.75324626
30MP0002088_abnormal_embryonic_growth/wei1.75085797
31MP0008260_abnormal_autophagy1.71496135
32MP0004197_abnormal_fetal_growth/weight/1.70554831
33MP0001986_abnormal_taste_sensitivity1.69626102
34MP0002084_abnormal_developmental_patter1.69136257
35MP0005171_absent_coat_pigmentation1.65954183
36MP0001697_abnormal_embryo_size1.63313564
37MP0009703_decreased_birth_body1.61984044
38MP0005174_abnormal_tail_pigmentation1.60556592
39MP0010352_gastrointestinal_tract_polyps1.54896538
40MP0009379_abnormal_foot_pigmentation1.54108162
41MP0003763_abnormal_thymus_physiology1.52958209
42MP0004133_heterotaxia1.51932346
43MP0003786_premature_aging1.50542272
44MP0001293_anophthalmia1.48712536
45MP0003890_abnormal_embryonic-extraembry1.47385227
46MP0010307_abnormal_tumor_latency1.46061247
47MP0008995_early_reproductive_senescence1.43826386
48MP0003718_maternal_effect1.43076320
49MP0006072_abnormal_retinal_apoptosis1.39636917
50MP0004808_abnormal_hematopoietic_stem1.38866512
51MP0002086_abnormal_extraembryonic_tissu1.36848776
52MP0002080_prenatal_lethality1.33049762
53MP0001485_abnormal_pinna_reflex1.32841882
54MP0002210_abnormal_sex_determination1.31710665
55MP0009672_abnormal_birth_weight1.30997417
56MP0000465_gastrointestinal_hemorrhage1.23954294
57MP0005671_abnormal_response_to1.23362101
58MP0002095_abnormal_skin_pigmentation1.22790231
59MP0003221_abnormal_cardiomyocyte_apopto1.21771763
60MP0001529_abnormal_vocalization1.21770592
61MP0002697_abnormal_eye_size1.20778120
62MP0010678_abnormal_skin_adnexa1.19239643
63MP0000490_abnormal_crypts_of1.18471913
64MP0004142_abnormal_muscle_tone1.17740599
65MP0000383_abnormal_hair_follicle1.16336480
66MP0000015_abnormal_ear_pigmentation1.15637226
67MP0000428_abnormal_craniofacial_morphol1.15350275
68MP0002234_abnormal_pharynx_morphology1.15018023
69MP0000703_abnormal_thymus_morphology1.13545059
70MP0002160_abnormal_reproductive_system1.13348484
71MP0003806_abnormal_nucleotide_metabolis1.13101513
72MP0001929_abnormal_gametogenesis1.12561167
73MP0001145_abnormal_male_reproductive1.10126010
74MP0003938_abnormal_ear_development1.09225255
75MP0002166_altered_tumor_susceptibility1.08621527
76MP0002638_abnormal_pupillary_reflex1.05442399
77MP0004147_increased_porphyrin_level1.05159404
78MP0003115_abnormal_respiratory_system1.04288046
79MP0000631_abnormal_neuroendocrine_gland1.03664183
80MP0003656_abnormal_erythrocyte_physiolo1.03547061
81MP0002233_abnormal_nose_morphology1.02378867
82MP0000372_irregular_coat_pigmentation1.01963458
83MP0001286_abnormal_eye_development1.01625289
84MP0002877_abnormal_melanocyte_morpholog1.00461451
85MP0002075_abnormal_coat/hair_pigmentati0.99029142
86MP0000026_abnormal_inner_ear0.98526120
87MP0003937_abnormal_limbs/digits/tail_de0.98455255
88MP0001186_pigmentation_phenotype0.98276478
89MP0003315_abnormal_perineum_morphology0.97947459
90MP0001915_intracranial_hemorrhage0.97447585
91MP0002092_abnormal_eye_morphology0.97242799
92MP0000653_abnormal_sex_gland0.96728043
93MP0000613_abnormal_salivary_gland0.96666766
94MP0000313_abnormal_cell_death0.95597536
95MP0002398_abnormal_bone_marrow0.95225618
96MP0005253_abnormal_eye_physiology0.94473027
97MP0005076_abnormal_cell_differentiation0.93688506
98MP0003950_abnormal_plasma_membrane0.92734829
99MP0003943_abnormal_hepatobiliary_system0.92691356
100MP0000350_abnormal_cell_proliferation0.91985881
101MP0004264_abnormal_extraembryonic_tissu0.90658353
102MP0004742_abnormal_vestibular_system0.90039005
103MP0000689_abnormal_spleen_morphology0.88797356
104MP0001299_abnormal_eye_distance/0.88510404
105MP0005391_vision/eye_phenotype0.88490575
106MP0006054_spinal_hemorrhage0.88257638
107MP0005621_abnormal_cell_physiology0.87369211
108MP0005389_reproductive_system_phenotype0.86638693
109MP0003935_abnormal_craniofacial_develop0.86624261
110MP0005384_cellular_phenotype0.86383942
111MP0008961_abnormal_basal_metabolism0.85581389
112MP0003119_abnormal_digestive_system0.85571250
113MP0000462_abnormal_digestive_system0.85268625
114MP0002722_abnormal_immune_system0.84628470
115MP0003698_abnormal_male_reproductive0.83981145
116MP0003787_abnormal_imprinting0.83713464
117MP0001800_abnormal_humoral_immune0.83355228
118MP0001905_abnormal_dopamine_level0.82614718
119MP0003385_abnormal_body_wall0.82121990
120MP0000716_abnormal_immune_system0.82048614
121MP0005551_abnormal_eye_electrophysiolog0.80935735
122MP0000647_abnormal_sebaceous_gland0.79059789
123MP0009333_abnormal_splenocyte_physiolog0.77999497
124MP0001963_abnormal_hearing_physiology0.77822289
125MP0002098_abnormal_vibrissa_morphology0.77483296
126MP0002420_abnormal_adaptive_immunity0.76793188
127MP0000049_abnormal_middle_ear0.76047436
128MP0003941_abnormal_skin_development0.75445152
129MP0001764_abnormal_homeostasis0.75077233
130MP0001730_embryonic_growth_arrest0.74092766
131MP0004134_abnormal_chest_morphology0.73919286
132MP0001873_stomach_inflammation0.73755763
133MP0003699_abnormal_female_reproductive0.73620887
134MP0001819_abnormal_immune_cell0.73570169
135MP0002006_tumorigenesis0.73337713
136MP0005275_abnormal_skin_tensile0.72855860
137MP0000432_abnormal_head_morphology0.72484658
138MP0005645_abnormal_hypothalamus_physiol0.72245143
139MP0001119_abnormal_female_reproductive0.72204604
140MP0002177_abnormal_outer_ear0.72172666
141MP0002019_abnormal_tumor_incidence0.72157717
142MP0002429_abnormal_blood_cell0.71994428
143MP0003861_abnormal_nervous_system0.71860146
144MP0002452_abnormal_antigen_presenting0.71539529
145MP0005646_abnormal_pituitary_gland0.71421473
146MP0002933_joint_inflammation0.69767542
147MP0005310_abnormal_salivary_gland0.69682519
148MP0002085_abnormal_embryonic_tissue0.69392395
149MP0003121_genomic_imprinting0.69198014
150MP0005220_abnormal_exocrine_pancreas0.68366443
151MP0005084_abnormal_gallbladder_morpholo0.68332871
152MP0003122_maternal_imprinting0.68097004
153MP0002751_abnormal_autonomic_nervous0.64254010
154MP0000358_abnormal_cell_content/0.63676328

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)4.22965012
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.22047685
3Papillary thyroid carcinoma (HP:0002895)3.71709967
4Duplicated collecting system (HP:0000081)3.54750877
5Reticulocytopenia (HP:0001896)3.40010850
6Abnormality of the renal collecting system (HP:0004742)3.37454945
7Overlapping toe (HP:0001845)3.30006075
8Embryonal renal neoplasm (HP:0011794)3.22710734
9Rhabdomyosarcoma (HP:0002859)3.22683958
10Microvesicular hepatic steatosis (HP:0001414)3.17215262
11Abnormality of chromosome stability (HP:0003220)3.08889137
12Basal cell carcinoma (HP:0002671)3.04327120
13Volvulus (HP:0002580)3.02147356
14Abnormality of the preputium (HP:0100587)3.01681544
15Biliary tract neoplasm (HP:0100574)2.98816182
16Thyroid carcinoma (HP:0002890)2.96818124
17Birth length less than 3rd percentile (HP:0003561)2.90831367
18Meckel diverticulum (HP:0002245)2.78404515
19Abnormality of the ileum (HP:0001549)2.77462193
20Ependymoma (HP:0002888)2.74452748
21Cortical dysplasia (HP:0002539)2.72978336
22Aplasia/Hypoplasia of the uvula (HP:0010293)2.71921140
23Progressive external ophthalmoplegia (HP:0000590)2.66413049
24Type I transferrin isoform profile (HP:0003642)2.60439192
25Acute myeloid leukemia (HP:0004808)2.59251130
263-Methylglutaconic aciduria (HP:0003535)2.58643092
27Septo-optic dysplasia (HP:0100842)2.55874432
28Absent thumb (HP:0009777)2.53087882
29Parakeratosis (HP:0001036)2.48778801
30Ectopic kidney (HP:0000086)2.42735402
31Aplasia/Hypoplasia of the sternum (HP:0006714)2.41858965
32Absent radius (HP:0003974)2.41067966
33Curly hair (HP:0002212)2.40901623
34Cystic hygroma (HP:0000476)2.39664839
35Neoplasm of the small intestine (HP:0100833)2.38930704
36Abnormality of DNA repair (HP:0003254)2.38744313
37Cerebral hypomyelination (HP:0006808)2.37097173
38Supernumerary spleens (HP:0009799)2.35904805
39Clubbing of toes (HP:0100760)2.35853863
40Duplication of thumb phalanx (HP:0009942)2.35563586
41Bone marrow hypocellularity (HP:0005528)2.33015392
42Breast hypoplasia (HP:0003187)2.32525911
43Colon cancer (HP:0003003)2.30849899
44Insidious onset (HP:0003587)2.29889814
45Termporal pattern (HP:0011008)2.29889814
46Aplasia involving forearm bones (HP:0009822)2.29279258
47Absent forearm bone (HP:0003953)2.29279258
48Malignant gastrointestinal tract tumors (HP:0006749)2.27613620
49Gastrointestinal carcinoma (HP:0002672)2.27613620
50Abnormality of cells of the erythroid lineage (HP:0012130)2.27523870
51Triphalangeal thumb (HP:0001199)2.26367745
52Myelodysplasia (HP:0002863)2.20216783
53Pancreatic cysts (HP:0001737)2.20088558
54Neoplasm of the colon (HP:0100273)2.19938522
55Acute lymphatic leukemia (HP:0006721)2.19662403
56Abnormal number of erythroid precursors (HP:0012131)2.19168450
57Capillary hemangiomas (HP:0005306)2.19107597
58Cafe-au-lait spot (HP:0000957)2.18285712
59Neoplasm of striated muscle (HP:0009728)2.16668796
60Aplasia/Hypoplasia of the sacrum (HP:0008517)2.15639340
61Intestinal atresia (HP:0011100)2.15577384
62Asplenia (HP:0001746)2.13949265
63Clitoromegaly (HP:0000057)2.13549138
64Reduced antithrombin III activity (HP:0001976)2.13196251
65Glioma (HP:0009733)2.12892372
66Pancreatic fibrosis (HP:0100732)2.11459684
67Premature graying of hair (HP:0002216)2.10585256
68Pallor (HP:0000980)2.09671649
69Neoplasm of the oral cavity (HP:0100649)2.09175969
70Duodenal stenosis (HP:0100867)2.08915034
71Small intestinal stenosis (HP:0012848)2.08915034
72Absent septum pellucidum (HP:0001331)2.08724914
73Agnosia (HP:0010524)2.08058020
74Increased hepatocellular lipid droplets (HP:0006565)2.07385298
75Pancreatic islet-cell hyperplasia (HP:0004510)2.06914599
76Absent rod-and cone-mediated responses on ERG (HP:0007688)2.06387074
77Increased nuchal translucency (HP:0010880)2.06213905
78Attenuation of retinal blood vessels (HP:0007843)2.06148232
79Medulloblastoma (HP:0002885)2.05906185
80Sandal gap (HP:0001852)2.05855231
81Abnormality of the septum pellucidum (HP:0007375)2.04160331
82True hermaphroditism (HP:0010459)2.03972562
83Macrocytic anemia (HP:0001972)2.03813522
84Combined immunodeficiency (HP:0005387)2.01804492
85Abnormal biliary tract morphology (HP:0012440)2.01411892
86Abnormality of the astrocytes (HP:0100707)2.01071890
87Astrocytoma (HP:0009592)2.01071890
88Embryonal neoplasm (HP:0002898)2.00746868
89Pancytopenia (HP:0001876)2.00231594
90Asymmetry of the thorax (HP:0001555)1.99990182
91Sloping forehead (HP:0000340)1.99242655
92Abnormality of midbrain morphology (HP:0002418)1.98494856
93Molar tooth sign on MRI (HP:0002419)1.98494856
94Broad palm (HP:0001169)1.98371191
95Aplastic anemia (HP:0001915)1.98271058
96Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.97628240
97Rough bone trabeculation (HP:0100670)1.95964752
98Deep philtrum (HP:0002002)1.94682455
99Lymphoma (HP:0002665)1.94398153
100Absent eyebrow (HP:0002223)1.93673821
101Abnormal protein glycosylation (HP:0012346)1.93165373
102Abnormal glycosylation (HP:0012345)1.93165373
103Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.93165373
104Abnormal protein N-linked glycosylation (HP:0012347)1.93165373
105Abnormality of the carotid arteries (HP:0005344)1.92613194
106Abnormality of the duodenum (HP:0002246)1.92480177
107Aplasia/Hypoplasia of the spleen (HP:0010451)1.92019011
108Ovarian neoplasm (HP:0100615)1.91076481
109Neuroblastic tumors (HP:0004376)1.89819772
110Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.89819772
111Neuroblastoma (HP:0003006)1.89819772
112Primitive neuroectodermal tumor (HP:0030065)1.89819772
113Horseshoe kidney (HP:0000085)1.89117141
114Acanthocytosis (HP:0001927)1.88594072
115IgM deficiency (HP:0002850)1.87719992
116Abnormal lung lobation (HP:0002101)1.87232218
117Renal Fanconi syndrome (HP:0001994)1.85814340
118B lymphocytopenia (HP:0010976)1.84975642
119Abnormality of B cell number (HP:0010975)1.84975642
120Abnormal biliary tract physiology (HP:0012439)1.84539820
121Bile duct proliferation (HP:0001408)1.84539820
122Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.84537429
123Neoplasm of the rectum (HP:0100743)1.83309411
124Arteriovenous malformation (HP:0100026)1.82817712
125Transitional cell carcinoma of the bladder (HP:0006740)1.81591529
126Abnormal trabecular bone morphology (HP:0100671)1.79526975
127Oral leukoplakia (HP:0002745)1.78902512
128Heterotopia (HP:0002282)1.78066632
129Abnormal hair whorl (HP:0010721)1.77796629
130Anencephaly (HP:0002323)1.77048820
131Breast carcinoma (HP:0003002)1.76864368
132Cupped ear (HP:0000378)1.76662686
133T lymphocytopenia (HP:0005403)1.76242067
134Freckling (HP:0001480)1.74749393
135Syringomyelia (HP:0003396)1.74600233
136Spinal cord lesions (HP:0100561)1.74600233
137Abnormal ciliary motility (HP:0012262)1.74140134
138Renal agenesis (HP:0000104)1.73848415
139Abnormality of cochlea (HP:0000375)1.73031046
140Patchy hypopigmentation of hair (HP:0011365)1.72009901
141Preaxial hand polydactyly (HP:0001177)1.71647841
142Spastic diplegia (HP:0001264)1.71623818
143Pelvic girdle muscle weakness (HP:0003749)1.71617961
144Abnormality of the hip-girdle musculature (HP:0001445)1.71572413
145Abnormality of the musculature of the pelvis (HP:0001469)1.71572413
146Type 2 muscle fiber atrophy (HP:0003554)1.71220311
147Abnormality of the labia minora (HP:0012880)1.71146419
148Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.70448069
149Exertional dyspnea (HP:0002875)1.70408879
150Dynein arm defect of respiratory motile cilia (HP:0012255)1.70337416
151Absent/shortened dynein arms (HP:0200106)1.70337416
152Protruding tongue (HP:0010808)1.70279454
153Uterine neoplasm (HP:0010784)1.70219529
154Medial flaring of the eyebrow (HP:0010747)1.70038957
155Dry hair (HP:0011359)1.69915932
156Prolonged neonatal jaundice (HP:0006579)1.69826579
157Prominent nose (HP:0000448)1.69604141
158Bladder carcinoma (HP:0002862)1.69537434
159Bladder neoplasm (HP:0009725)1.69537434
160Severe combined immunodeficiency (HP:0004430)1.69271286
161Abnormal respiratory motile cilium morphology (HP:0005938)1.69140481
162Abnormal respiratory epithelium morphology (HP:0012253)1.69140481
16311 pairs of ribs (HP:0000878)1.69026377
164Optic nerve coloboma (HP:0000588)1.68142737
165Broad alveolar ridges (HP:0000187)1.68030432
166Neoplasm of the thyroid gland (HP:0100031)1.67735968
167Nephroblastoma (Wilms tumor) (HP:0002667)1.67155157
168Hypoplastic labia majora (HP:0000059)1.67143253
169Partial duplication of thumb phalanx (HP:0009944)1.66423093
170Stenosis of the external auditory canal (HP:0000402)1.65171024
171Central scotoma (HP:0000603)1.64937215
172Lipid accumulation in hepatocytes (HP:0006561)1.64797344
173Shoulder girdle muscle weakness (HP:0003547)1.64707528
174Abnormality of chromosome segregation (HP:0002916)1.59682038
175Aplasia/hypoplasia of the humerus (HP:0006507)1.59478735

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK163.42693222
2BUB13.38000268
3SRPK12.82463548
4TNIK2.65126254
5MKNK12.34999236
6TLK12.32966432
7BRD42.32476340
8MKNK22.32232075
9MAP3K102.31152576
10CDC72.31094462
11VRK12.30483741
12WEE12.24758642
13PLK42.10373711
14TAF12.09875775
15IRAK41.90812732
16BRSK21.85577038
17ZAK1.81249924
18TTK1.80750274
19TRIM281.74608011
20EIF2AK21.72069343
21EIF2AK11.71076013
22EEF2K1.63551842
23EIF2AK31.60343583
24CDK61.55378086
25YES11.54659097
26PBK1.50098335
27BMPR1B1.49919950
28ERBB31.47266297
29BLK1.46783802
30MAP3K41.45408702
31CDK191.45347091
32NEK21.43285381
33ATR1.42519648
34STK31.40022992
35ACVR1B1.38447080
36RPS6KA41.37101249
37CDK71.35823432
38DYRK31.35075084
39STK391.33567098
40IRAK31.30331720
41PLK11.28180448
42TXK1.26078118
43BCR1.25256567
44CHEK21.24981159
45SCYL21.23695025
46NLK1.19211832
47LATS11.16678392
48STK38L1.15199487
49IRAK11.12248328
50ALK1.11785861
51MST41.10398780
52FGFR11.09641739
53PLK31.08410455
54CASK1.08371978
55PASK1.06039431
56TEC1.03346489
57DYRK21.01930451
58AURKB1.01793610
59ADRBK20.99371496
60CDK30.98107445
61KSR10.97230423
62OXSR10.96459355
63STK40.94227364
64FGFR30.94216323
65GRK10.91571989
66RPS6KA50.90709783
67NEK60.88793117
68CDK120.87388333
69WNK10.86948587
70STK100.85020613
71MAP4K20.85018908
72STK240.84526853
73RAF10.84404427
74IRAK20.81762307
75ATM0.79766761
76CSNK1A1L0.79304213
77NEK90.79297987
78MUSK0.79136382
79AURKA0.78831806
80CDK80.78434680
81TSSK60.78115511
82CHEK10.77694404
83CSNK1G30.77650313
84MELK0.74897456
85RPS6KB20.73651407
86NUAK10.71093640
87FGFR40.70014713
88PNCK0.69957681
89RPS6KB10.68860356
90MAPKAPK50.68086247
91CSNK1G10.67141701
92KSR20.66501367
93PDGFRA0.65718773
94PKN20.65420124
95MAP4K10.65327351
96INSRR0.64882192
97CSF1R0.64551423
98BTK0.64000741
99LYN0.63445869
100CDK40.62954714
101BRSK10.60905994
102GRK70.60610278
103PKN10.57923336
104CLK10.57049299
105MAP3K140.52449947
106FGFR20.51209556
107CSNK2A10.50716029
108BRAF0.50378761
109CSNK2A20.49921189
110PLK20.49499900
111CCNB10.47576980
112ERBB40.47486609
113PIM20.47383249
114HIPK20.47092498
115CDK90.46812302
116CSNK1E0.45977885
117CDK10.44303367
118NEK10.43355744
119SIK30.43337563
120IKBKB0.42735580
121DYRK1A0.42540634
122SGK20.42044083
123CDK20.41966975
124EPHA20.41058017
125TGFBR10.40620949
126LCK0.40545911
127KIT0.40191635
128JAK10.39345434
129RET0.38947289
130WNK30.38660702
131NME20.38395087
132MAP2K70.38393785
133PRKDC0.38017058
134EGFR0.37671796
135AKT30.36534533
136PIK3CG0.36350955
137MAPK70.36119244
138MAPK130.35962019
139JAK30.34496863
140CAMK2B0.34023209
141FLT30.33846927
142PIM10.33380245
143CSNK1D0.30753401
144MAPK140.30672154
145GSK3B0.30130040

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.77576170
2Mismatch repair_Homo sapiens_hsa034303.60861752
3RNA polymerase_Homo sapiens_hsa030203.54649977
4Homologous recombination_Homo sapiens_hsa034403.44539012
5Non-homologous end-joining_Homo sapiens_hsa034503.22517124
6Ribosome_Homo sapiens_hsa030103.17093922
7Fanconi anemia pathway_Homo sapiens_hsa034603.15487630
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.04060425
9Spliceosome_Homo sapiens_hsa030402.92042784
10Base excision repair_Homo sapiens_hsa034102.58536839
11Nucleotide excision repair_Homo sapiens_hsa034202.51502242
12Basal transcription factors_Homo sapiens_hsa030222.49655836
13Proteasome_Homo sapiens_hsa030502.36069413
14Pyrimidine metabolism_Homo sapiens_hsa002402.33814196
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.27110889
16RNA degradation_Homo sapiens_hsa030182.08469486
17Protein export_Homo sapiens_hsa030602.06424682
18RNA transport_Homo sapiens_hsa030131.97307254
19Cell cycle_Homo sapiens_hsa041101.83669331
20One carbon pool by folate_Homo sapiens_hsa006701.78106199
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.74020403
22Thyroid cancer_Homo sapiens_hsa052161.65723107
23Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.62975349
24Purine metabolism_Homo sapiens_hsa002301.51299605
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.46366483
26Primary immunodeficiency_Homo sapiens_hsa053401.37751760
27Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.36113933
28Propanoate metabolism_Homo sapiens_hsa006401.30753068
29Steroid biosynthesis_Homo sapiens_hsa001001.27933528
30Colorectal cancer_Homo sapiens_hsa052101.25709651
31Oocyte meiosis_Homo sapiens_hsa041141.25479642
32Folate biosynthesis_Homo sapiens_hsa007901.24938720
33Ether lipid metabolism_Homo sapiens_hsa005651.24826684
34mRNA surveillance pathway_Homo sapiens_hsa030151.21542089
35Chronic myeloid leukemia_Homo sapiens_hsa052201.18610885
36Systemic lupus erythematosus_Homo sapiens_hsa053221.10569026
37Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.10446367
38Phototransduction_Homo sapiens_hsa047441.09260137
39Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.08096581
40Prostate cancer_Homo sapiens_hsa052151.07367581
41Maturity onset diabetes of the young_Homo sapiens_hsa049501.03198360
42p53 signaling pathway_Homo sapiens_hsa041151.00651063
43Autoimmune thyroid disease_Homo sapiens_hsa053201.00228184
44Intestinal immune network for IgA production_Homo sapiens_hsa046720.96031960
45Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.95281836
46Vitamin B6 metabolism_Homo sapiens_hsa007500.93130997
47Non-small cell lung cancer_Homo sapiens_hsa052230.90615445
48Fatty acid elongation_Homo sapiens_hsa000620.87278154
49Biosynthesis of amino acids_Homo sapiens_hsa012300.87004947
50Arachidonic acid metabolism_Homo sapiens_hsa005900.84346571
51Linoleic acid metabolism_Homo sapiens_hsa005910.84105601
52Adherens junction_Homo sapiens_hsa045200.82425457
53Herpes simplex infection_Homo sapiens_hsa051680.81671462
54Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.81196366
55Sphingolipid metabolism_Homo sapiens_hsa006000.80755823
56Endometrial cancer_Homo sapiens_hsa052130.79780096
57Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.78812769
58Renal cell carcinoma_Homo sapiens_hsa052110.78236860
59Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.78057766
60Pancreatic cancer_Homo sapiens_hsa052120.75856322
61Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.73643823
62Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.72938013
63Transcriptional misregulation in cancer_Homo sapiens_hsa052020.71944390
64B cell receptor signaling pathway_Homo sapiens_hsa046620.71384709
65Epstein-Barr virus infection_Homo sapiens_hsa051690.70769080
66Hedgehog signaling pathway_Homo sapiens_hsa043400.69962108
67Wnt signaling pathway_Homo sapiens_hsa043100.69373508
68Melanoma_Homo sapiens_hsa052180.67840257
69Regulation of autophagy_Homo sapiens_hsa041400.67404610
70NF-kappa B signaling pathway_Homo sapiens_hsa040640.66707210
71Huntingtons disease_Homo sapiens_hsa050160.63133252
72alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.62441842
73Lysine degradation_Homo sapiens_hsa003100.62159861
74Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.61355506
75Selenocompound metabolism_Homo sapiens_hsa004500.60785010
76mTOR signaling pathway_Homo sapiens_hsa041500.60468356
77Oxidative phosphorylation_Homo sapiens_hsa001900.60295341
78Sulfur relay system_Homo sapiens_hsa041220.60265589
79Other glycan degradation_Homo sapiens_hsa005110.60124898
80Long-term depression_Homo sapiens_hsa047300.59780052
81Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.59140212
82ErbB signaling pathway_Homo sapiens_hsa040120.58629434
83Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.58596334
84Hematopoietic cell lineage_Homo sapiens_hsa046400.56596488
85Inositol phosphate metabolism_Homo sapiens_hsa005620.56459973
86Acute myeloid leukemia_Homo sapiens_hsa052210.56432507
87Dorso-ventral axis formation_Homo sapiens_hsa043200.56243794
88Choline metabolism in cancer_Homo sapiens_hsa052310.56076759
89Central carbon metabolism in cancer_Homo sapiens_hsa052300.55426678
90Fatty acid biosynthesis_Homo sapiens_hsa000610.54890668
91Parkinsons disease_Homo sapiens_hsa050120.54434705
92Small cell lung cancer_Homo sapiens_hsa052220.54378974
93Allograft rejection_Homo sapiens_hsa053300.53316337
94RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.52262220
95Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.52194626
96Metabolic pathways_Homo sapiens_hsa011000.51959905
97Glioma_Homo sapiens_hsa052140.51258335
98FoxO signaling pathway_Homo sapiens_hsa040680.51036674
99Phosphatidylinositol signaling system_Homo sapiens_hsa040700.50684209
100Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.50553262
101Hippo signaling pathway_Homo sapiens_hsa043900.45653669
102Drug metabolism - other enzymes_Homo sapiens_hsa009830.45615393
103SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45164020
104Glutathione metabolism_Homo sapiens_hsa004800.44602839
1052-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.43177433
106Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42878101
107Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42375415
108Measles_Homo sapiens_hsa051620.42299685
109Proteoglycans in cancer_Homo sapiens_hsa052050.40891561
110Alcoholism_Homo sapiens_hsa050340.40538526
111Cysteine and methionine metabolism_Homo sapiens_hsa002700.40314975
112Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.40058783
113Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.38947168
114Pathways in cancer_Homo sapiens_hsa052000.38235913
115Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.37135325
116Circadian rhythm_Homo sapiens_hsa047100.36742191
117Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.36126473
118TGF-beta signaling pathway_Homo sapiens_hsa043500.35659445
119Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.35235619
120Prolactin signaling pathway_Homo sapiens_hsa049170.34507768
121Viral carcinogenesis_Homo sapiens_hsa052030.34410359
122Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.32119936
123Long-term potentiation_Homo sapiens_hsa047200.31881028
124Antigen processing and presentation_Homo sapiens_hsa046120.30636508
125HIF-1 signaling pathway_Homo sapiens_hsa040660.30600006
126Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.29328620
127Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.29240566
128Histidine metabolism_Homo sapiens_hsa003400.28855932
129Neurotrophin signaling pathway_Homo sapiens_hsa047220.28443565
130Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.27855276
131ABC transporters_Homo sapiens_hsa020100.27736045
132HTLV-I infection_Homo sapiens_hsa051660.27170789
133Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.26609865
134Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.26394109
135T cell receptor signaling pathway_Homo sapiens_hsa046600.25946146
136Steroid hormone biosynthesis_Homo sapiens_hsa001400.25936569
137Shigellosis_Homo sapiens_hsa051310.25694125
138Taste transduction_Homo sapiens_hsa047420.25481883
139N-Glycan biosynthesis_Homo sapiens_hsa005100.24834987
140Retinol metabolism_Homo sapiens_hsa008300.24635340
141Arginine and proline metabolism_Homo sapiens_hsa003300.23770211
142Vitamin digestion and absorption_Homo sapiens_hsa049770.23082150
143Notch signaling pathway_Homo sapiens_hsa043300.22696842
144Asthma_Homo sapiens_hsa053100.20506294
145NOD-like receptor signaling pathway_Homo sapiens_hsa046210.20024336
146Alzheimers disease_Homo sapiens_hsa050100.19275320
147Graft-versus-host disease_Homo sapiens_hsa053320.17302870
148Basal cell carcinoma_Homo sapiens_hsa052170.16758022
149Sulfur metabolism_Homo sapiens_hsa009200.16687264
150Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.13973687
151MicroRNAs in cancer_Homo sapiens_hsa052060.13898194
152Glycerophospholipid metabolism_Homo sapiens_hsa005640.13074069
153Tyrosine metabolism_Homo sapiens_hsa003500.12631452
154Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.11885800
155Hepatitis B_Homo sapiens_hsa051610.11841999

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