DCAF4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a WD repeat-containing protein that interacts with the Cul4-Ddb1 E3 ligase macromolecular complex. Multiple alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1purine nucleobase biosynthetic process (GO:0009113)5.45355855
2nucleobase biosynthetic process (GO:0046112)5.33972948
3maturation of SSU-rRNA (GO:0030490)4.89654009
4DNA deamination (GO:0045006)4.79671763
5ribosome assembly (GO:0042255)4.66915338
6formation of translation preinitiation complex (GO:0001731)4.66493480
7peptidyl-histidine modification (GO:0018202)4.60695781
8mitotic metaphase plate congression (GO:0007080)4.57224292
9ribosome biogenesis (GO:0042254)4.46561146
10proteasome assembly (GO:0043248)4.32133490
11mitochondrial RNA metabolic process (GO:0000959)4.32058130
12DNA replication checkpoint (GO:0000076)4.24822619
13DNA strand elongation involved in DNA replication (GO:0006271)4.21395705
14ribosomal large subunit biogenesis (GO:0042273)4.11959761
15ribonucleoprotein complex biogenesis (GO:0022613)4.10050729
16rRNA modification (GO:0000154)4.07583525
17transcription elongation from RNA polymerase III promoter (GO:0006385)4.06011275
18termination of RNA polymerase III transcription (GO:0006386)4.06011275
19somatic hypermutation of immunoglobulin genes (GO:0016446)4.04154013
20somatic diversification of immune receptors via somatic mutation (GO:0002566)4.04154013
21DNA replication initiation (GO:0006270)4.03331999
22DNA strand elongation (GO:0022616)4.00995270
23ribosomal small subunit assembly (GO:0000028)3.89934208
24pseudouridine synthesis (GO:0001522)3.85198260
25folic acid metabolic process (GO:0046655)3.83981119
26anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.81073806
27negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.79680173
28rRNA processing (GO:0006364)3.77693638
29positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.75511236
30regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.75346858
31telomere maintenance via semi-conservative replication (GO:0032201)3.74123884
32metaphase plate congression (GO:0051310)3.72697104
33spliceosomal snRNP assembly (GO:0000387)3.72419072
34tRNA methylation (GO:0030488)3.72374243
35regulation of spindle organization (GO:0090224)3.70958969
36transcription from mitochondrial promoter (GO:0006390)3.69653124
37rRNA metabolic process (GO:0016072)3.65398572
38regulation of mitochondrial translation (GO:0070129)3.61830014
39termination of RNA polymerase I transcription (GO:0006363)3.61383749
40transcription elongation from RNA polymerase I promoter (GO:0006362)3.60721237
41regulation of nuclear cell cycle DNA replication (GO:0033262)3.58521873
42regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.57730293
43translational initiation (GO:0006413)3.52671880
44protein localization to kinetochore (GO:0034501)3.51320776
457-methylguanosine mRNA capping (GO:0006370)3.50443858
46transcription from RNA polymerase I promoter (GO:0006360)3.48851100
47protein K6-linked ubiquitination (GO:0085020)3.46195190
48negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.44723884
49negative regulation of ligase activity (GO:0051352)3.44723884
50tRNA modification (GO:0006400)3.43033730
51ribosomal small subunit biogenesis (GO:0042274)3.42972456
52IMP biosynthetic process (GO:0006188)3.42664563
53rRNA transcription (GO:0009303)3.42246203
54tRNA processing (GO:0008033)3.41622818
55RNA capping (GO:0036260)3.40829770
567-methylguanosine RNA capping (GO:0009452)3.40829770
57positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.40065343
58viral transcription (GO:0019083)3.38946380
59translational termination (GO:0006415)3.38361089
60transcription-coupled nucleotide-excision repair (GO:0006283)3.35728226
61tRNA metabolic process (GO:0006399)3.33988587
62CENP-A containing nucleosome assembly (GO:0034080)3.33947799
63telomere maintenance via recombination (GO:0000722)3.31860280
64DNA unwinding involved in DNA replication (GO:0006268)3.30777040
65tRNA aminoacylation for protein translation (GO:0006418)3.30755162
66ncRNA 3-end processing (GO:0043628)3.29931272
67chromatin remodeling at centromere (GO:0031055)3.29609828
68ubiquinone biosynthetic process (GO:0006744)3.28921173
69metallo-sulfur cluster assembly (GO:0031163)3.28079863
70iron-sulfur cluster assembly (GO:0016226)3.28079863
71mitotic nuclear envelope disassembly (GO:0007077)3.27784041
72negative regulation of chromosome segregation (GO:0051985)3.27273988
73regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.25478665
74folic acid-containing compound biosynthetic process (GO:0009396)3.25366423
75negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.25313270
76negative regulation of sister chromatid segregation (GO:0033046)3.25313270
77negative regulation of mitotic sister chromatid separation (GO:2000816)3.25313270
78negative regulation of mitotic sister chromatid segregation (GO:0033048)3.25313270
79tRNA aminoacylation (GO:0043039)3.24970221
80amino acid activation (GO:0043038)3.24970221
81telomere maintenance via telomere lengthening (GO:0010833)3.24014845
82cellular component biogenesis (GO:0044085)3.23479126
83positive regulation of ligase activity (GO:0051351)3.22710127
84protein targeting to mitochondrion (GO:0006626)3.21483426
85maturation of 5.8S rRNA (GO:0000460)3.21401737
86mitotic spindle assembly checkpoint (GO:0007094)3.19639655
87transcription initiation from RNA polymerase I promoter (GO:0006361)3.19601903
88L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.18542403
89ncRNA processing (GO:0034470)3.18247217
90mitotic spindle checkpoint (GO:0071174)3.17598086
91translational elongation (GO:0006414)3.17364221
92spindle checkpoint (GO:0031577)3.16487438
93establishment of protein localization to mitochondrial membrane (GO:0090151)3.16334914
94negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.15783648
95signal transduction involved in DNA damage checkpoint (GO:0072422)3.14448712
96signal transduction involved in DNA integrity checkpoint (GO:0072401)3.14448712
97rRNA methylation (GO:0031167)3.13982416
98protein localization to chromosome, centromeric region (GO:0071459)3.13975902
99spindle assembly checkpoint (GO:0071173)3.13659463
100signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.12299655
101signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.12299655
102signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.12299655
103mannosylation (GO:0097502)3.11694422
104mitotic recombination (GO:0006312)3.10696533
105base-excision repair, AP site formation (GO:0006285)3.10551864
106signal transduction involved in cell cycle checkpoint (GO:0072395)3.09879675
107DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.09862969
108G1/S transition of mitotic cell cycle (GO:0000082)3.08179785
109cell cycle G1/S phase transition (GO:0044843)3.08179785
110regulation of translation in response to stress (GO:0043555)3.07087090
111mitochondrial respiratory chain complex assembly (GO:0033108)3.06607138
112regulation of ubiquitin-protein transferase activity (GO:0051438)3.05945657
113establishment of protein localization to mitochondrion (GO:0072655)3.05826847
114signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.05531167
115intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.05531167
116GMP metabolic process (GO:0046037)3.04816404
117ncRNA metabolic process (GO:0034660)3.04653189
118regulation of mitotic spindle organization (GO:0060236)3.03908177
119DNA replication-independent nucleosome assembly (GO:0006336)3.02472303
120DNA replication-independent nucleosome organization (GO:0034724)3.02472303
121attachment of spindle microtubules to kinetochore (GO:0008608)3.01973356
122DNA replication-dependent nucleosome assembly (GO:0006335)3.01935166
123DNA replication-dependent nucleosome organization (GO:0034723)3.01935166
124L-methionine salvage (GO:0071267)3.01669241
125L-methionine biosynthetic process (GO:0071265)3.01669241
126amino acid salvage (GO:0043102)3.01669241
127membrane disassembly (GO:0030397)3.01593953
128nuclear envelope disassembly (GO:0051081)3.01593953
129GDP-mannose metabolic process (GO:0019673)2.96901092
130histone arginine methylation (GO:0034969)2.94647001
131RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.94387143
132tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.94387143
133piRNA metabolic process (GO:0034587)2.94244259
134ubiquinone metabolic process (GO:0006743)2.91379671
135protein complex biogenesis (GO:0070271)2.90853550
136spliceosomal tri-snRNP complex assembly (GO:0000244)2.89990043
137base-excision repair (GO:0006284)2.88285890
138RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)2.87129306
139establishment of integrated proviral latency (GO:0075713)2.83899955
140mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.83059443
141mitochondrial respiratory chain complex I assembly (GO:0032981)2.83059443
142NADH dehydrogenase complex assembly (GO:0010257)2.83059443
143RNA methylation (GO:0001510)2.81254259
144peptidyl-arginine omega-N-methylation (GO:0035247)2.81056932
145protein localization to mitochondrion (GO:0070585)2.80798288
146DNA methylation involved in gamete generation (GO:0043046)2.78907603
147DNA catabolic process, exonucleolytic (GO:0000738)2.76174605
148pentose metabolic process (GO:0019321)2.75897665
149nucleotide-excision repair, DNA gap filling (GO:0006297)2.75636015
150cullin deneddylation (GO:0010388)2.75247957
151regulation of cellular amino acid metabolic process (GO:0006521)2.74426541
152viral mRNA export from host cell nucleus (GO:0046784)2.74282805
153pteridine-containing compound biosynthetic process (GO:0042559)2.74014519
154protein deneddylation (GO:0000338)2.72342950
155RNA modification (GO:0009451)2.71111541

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.43862650
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.46793704
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.58463292
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.43904722
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.42430880
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.41691287
7ETS1_20019798_ChIP-Seq_JURKAT_Human3.38350734
8MYC_19079543_ChIP-ChIP_MESCs_Mouse3.30468707
9EST1_17652178_ChIP-ChIP_JURKAT_Human3.16419325
10GABP_17652178_ChIP-ChIP_JURKAT_Human3.13891642
11FOXM1_23109430_ChIP-Seq_U2OS_Human3.11743756
12MYC_18358816_ChIP-ChIP_MESCs_Mouse3.11013848
13CREB1_15753290_ChIP-ChIP_HEK293T_Human3.07626118
14MYC_19030024_ChIP-ChIP_MESCs_Mouse3.00141152
15E2F4_17652178_ChIP-ChIP_JURKAT_Human2.93481629
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.63124862
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.53869610
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.52019681
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.41029701
20NELFA_20434984_ChIP-Seq_ESCs_Mouse2.39419565
21XRN2_22483619_ChIP-Seq_HELA_Human2.38345089
22VDR_23849224_ChIP-Seq_CD4+_Human2.35852149
23MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.33242840
24E2F1_18555785_ChIP-Seq_MESCs_Mouse2.20299678
25THAP11_20581084_ChIP-Seq_MESCs_Mouse2.18107012
26NANOG_18555785_ChIP-Seq_MESCs_Mouse2.17836338
27* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.11626480
28YY1_21170310_ChIP-Seq_MESCs_Mouse2.07091295
29POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.04090767
30GABP_19822575_ChIP-Seq_HepG2_Human2.01731963
31FOXP3_21729870_ChIP-Seq_TREG_Human1.97451358
32DCP1A_22483619_ChIP-Seq_HELA_Human1.96384515
33MYCN_18555785_ChIP-Seq_MESCs_Mouse1.95262575
34AR_21909140_ChIP-Seq_LNCAP_Human1.94718488
35MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.92178187
36TTF2_22483619_ChIP-Seq_HELA_Human1.85468800
37CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.82805756
38POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.80285454
39CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.77388349
40CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.69669596
41YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.67281373
42ELF1_17652178_ChIP-ChIP_JURKAT_Human1.66832840
43SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.63991766
44ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.61770224
45SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.60985832
46PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60435609
47CIITA_25753668_ChIP-Seq_RAJI_Human1.60049426
48KDM5A_27292631_Chip-Seq_BREAST_Human1.55259051
49E2F1_21310950_ChIP-Seq_MCF-7_Human1.54613689
50ZNF274_21170338_ChIP-Seq_K562_Hela1.52333455
51POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.52218080
52KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.51806273
53ZFX_18555785_ChIP-Seq_MESCs_Mouse1.50421842
54FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.50146988
55SRF_21415370_ChIP-Seq_HL-1_Mouse1.49743114
56STAT3_1855785_ChIP-Seq_MESCs_Mouse1.49682853
57ESR1_15608294_ChIP-ChIP_MCF-7_Human1.46383730
58SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.40048314
59KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.38284557
60KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.38284557
61KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.38284557
62PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.35199592
63KLF4_18555785_ChIP-Seq_MESCs_Mouse1.34402063
64NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.33378034
65TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.33138719
66DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.32997965
67CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.31592189
68TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.30900739
69HOXB4_20404135_ChIP-ChIP_EML_Mouse1.27952453
70SOX2_18555785_ChIP-Seq_MESCs_Mouse1.26258413
71ELK1_19687146_ChIP-ChIP_HELA_Human1.25903183
72MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.24959594
73KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.22817456
74KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.21555563
75CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.19106496
76DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.13568295
77SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.13421658
78ZNF263_19887448_ChIP-Seq_K562_Human1.12900329
79ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.11934772
80BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.11292432
81NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.11254179
82NOTCH1_21737748_ChIP-Seq_TLL_Human1.10692109
83FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.07656661
84SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.07596702
85CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.07556293
86CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.05173096
87NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.04983751
88TCF3_18692474_ChIP-Seq_MEFs_Mouse1.04908039
89RBPJ_22232070_ChIP-Seq_NCS_Mouse1.04556368
90TFEB_21752829_ChIP-Seq_HELA_Human1.03565656
91SOX2_18692474_ChIP-Seq_MEFs_Mouse1.03495247
92FOXP1_21924763_ChIP-Seq_HESCs_Human1.02421299
93PADI4_21655091_ChIP-ChIP_MCF-7_Human1.02142586
94ERG_20887958_ChIP-Seq_HPC-7_Mouse1.01664791
95OCT4_18692474_ChIP-Seq_MEFs_Mouse1.01123593
96E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.00888191
97EGR1_19374776_ChIP-ChIP_THP-1_Human0.99890586
98NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.99046519
99NANOG_21062744_ChIP-ChIP_HESCs_Human0.97835261
100ELK1_22589737_ChIP-Seq_MCF10A_Human0.97458796
101CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.96773058
102MYC_22102868_ChIP-Seq_BL_Human0.94236055
103HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.94222470
104IRF1_19129219_ChIP-ChIP_H3396_Human0.93662063
105TBX5_21415370_ChIP-Seq_HL-1_Mouse0.93556713
106ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.92084745
107PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.90648482
108FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90043814
109ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.89787645
110TP63_19390658_ChIP-ChIP_HaCaT_Human0.89736139
111POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.89095323
112GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.87701302
113CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.87383584
114HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.85731750
115TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.85057342
116SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.84854755
117SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.84693198
118ELF5_23300383_ChIP-Seq_T47D_Human0.84490264
119MYC_18940864_ChIP-ChIP_HL60_Human0.84100124
120SALL1_21062744_ChIP-ChIP_HESCs_Human0.83895602
121HIF1A_21447827_ChIP-Seq_MCF-7_Human0.80110313
122TET1_21451524_ChIP-Seq_MESCs_Mouse0.78863819
123PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.78594829

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching6.03107465
2MP0003111_abnormal_nucleus_morphology5.07219252
3MP0004957_abnormal_blastocyst_morpholog4.82979002
4MP0010094_abnormal_chromosome_stability4.52158591
5MP0003077_abnormal_cell_cycle4.01480305
6MP0008058_abnormal_DNA_repair3.69575165
7MP0008057_abnormal_DNA_replication3.29761821
8MP0003718_maternal_effect3.15843756
9MP0005451_abnormal_body_composition3.01603646
10MP0008877_abnormal_DNA_methylation2.96653596
11MP0008932_abnormal_embryonic_tissue2.90977173
12MP0001730_embryonic_growth_arrest2.55600065
13MP0008007_abnormal_cellular_replicative2.53617716
14MP0003123_paternal_imprinting2.51807234
15MP0003786_premature_aging2.45932743
16MP0000350_abnormal_cell_proliferation2.17902876
17MP0008260_abnormal_autophagy2.16145088
18MP0003315_abnormal_perineum_morphology2.10916768
19MP0002396_abnormal_hematopoietic_system1.89959169
20MP0001873_stomach_inflammation1.85875797
21MP0005380_embryogenesis_phenotype1.84803384
22MP0001672_abnormal_embryogenesis/_devel1.84803384
23MP0000372_irregular_coat_pigmentation1.82161160
24MP0001697_abnormal_embryo_size1.81423577
25MP0009780_abnormal_chondrocyte_physiolo1.75839661
26MP0002653_abnormal_ependyma_morphology1.75443919
27MP0002080_prenatal_lethality1.70095724
28MP0003806_abnormal_nucleotide_metabolis1.66293002
29MP0002085_abnormal_embryonic_tissue1.60411114
30MP0003984_embryonic_growth_retardation1.60299458
31MP0002088_abnormal_embryonic_growth/wei1.56351884
32MP0005083_abnormal_biliary_tract1.55202123
33MP0008872_abnormal_physiological_respon1.54072811
34MP0002210_abnormal_sex_determination1.52558339
35MP0003567_abnormal_fetal_cardiomyocyte1.52169793
36MP0000313_abnormal_cell_death1.45850445
37MP0004147_increased_porphyrin_level1.44575285
38MP0001145_abnormal_male_reproductive1.41966594
39MP0002084_abnormal_developmental_patter1.39185260
40MP0002160_abnormal_reproductive_system1.36905511
41MP0010352_gastrointestinal_tract_polyps1.35269031
42MP0000427_abnormal_hair_cycle1.35236617
43MP0010030_abnormal_orbit_morphology1.33666366
44MP0000383_abnormal_hair_follicle1.30438616
45MP0003941_abnormal_skin_development1.30021421
46MP0002086_abnormal_extraembryonic_tissu1.27439340
47MP0001293_anophthalmia1.27433547
48MP0000490_abnormal_crypts_of1.26165087
49MP0001929_abnormal_gametogenesis1.26001265
50MP0003878_abnormal_ear_physiology1.25158538
51MP0005377_hearing/vestibular/ear_phenot1.25158538
52MP0010307_abnormal_tumor_latency1.25041963
53MP0006292_abnormal_olfactory_placode1.22959754
54MP0009697_abnormal_copulation1.21449936
55MP0000653_abnormal_sex_gland1.21345687
56MP0000537_abnormal_urethra_morphology1.20339938
57MP0004133_heterotaxia1.20225970
58MP0003950_abnormal_plasma_membrane1.19930895
59MP0003119_abnormal_digestive_system1.18547995
60MP0001764_abnormal_homeostasis1.18069792
61MP0002019_abnormal_tumor_incidence1.17431478
62MP0004233_abnormal_muscle_weight1.16848123
63MP0008875_abnormal_xenobiotic_pharmacok1.16003856
64MP0000358_abnormal_cell_content/1.14073839
65MP0002254_reproductive_system_inflammat1.13436674
66MP0003186_abnormal_redox_activity1.11911478
67MP0004197_abnormal_fetal_growth/weight/1.11879343
68MP0009333_abnormal_splenocyte_physiolog1.10078392
69MP0003890_abnormal_embryonic-extraembry1.09330060
70MP0006036_abnormal_mitochondrial_physio1.09237317
71MP0000462_abnormal_digestive_system1.09166498
72MP0005389_reproductive_system_phenotype1.07684811
73MP0006035_abnormal_mitochondrial_morpho1.06672056
74MP0001545_abnormal_hematopoietic_system1.03772010
75MP0005397_hematopoietic_system_phenotyp1.03772010
76MP0003943_abnormal_hepatobiliary_system1.02640249
77MP0005310_abnormal_salivary_gland0.98896597
78MP0002796_impaired_skin_barrier0.96974490
79MP0009840_abnormal_foam_cell0.96572447
80MP0000750_abnormal_muscle_regeneration0.95932099
81MP0003763_abnormal_thymus_physiology0.95151072
82MP0005395_other_phenotype0.94930016
83MP0005410_abnormal_fertilization0.94300790
84MP0000647_abnormal_sebaceous_gland0.92239330
85MP0005058_abnormal_lysosome_morphology0.91614941
86MP0000538_abnormal_urinary_bladder0.91015803
87MP0004185_abnormal_adipocyte_glucose0.89452106
88MP0002751_abnormal_autonomic_nervous0.89407849
89MP0003195_calcinosis0.88731408
90MP0003221_abnormal_cardiomyocyte_apopto0.88698291
91MP0005384_cellular_phenotype0.86046296
92MP0002938_white_spotting0.85403541
93MP0005075_abnormal_melanosome_morpholog0.84787859
94MP0004808_abnormal_hematopoietic_stem0.84505419
95MP0010386_abnormal_urinary_bladder0.83528093
96MP0009672_abnormal_birth_weight0.81398072
97MP0001542_abnormal_bone_strength0.81264414
98MP0002111_abnormal_tail_morphology0.80861640
99MP0005408_hypopigmentation0.79439416
100MP0005621_abnormal_cell_physiology0.78832157
101MP0004264_abnormal_extraembryonic_tissu0.78268562
102MP0002876_abnormal_thyroid_physiology0.78088283
103MP0001119_abnormal_female_reproductive0.78075228
104MP0003121_genomic_imprinting0.77440100
105MP0003698_abnormal_male_reproductive0.77323596
106MP0003136_yellow_coat_color0.77257185
107MP0008995_early_reproductive_senescence0.75957508
108MP0002132_abnormal_respiratory_system0.75253658
109MP0002837_dystrophic_cardiac_calcinosis0.75081600
110MP0001661_extended_life_span0.73264293
111MP0002163_abnormal_gland_morphology0.72893119
112MP0004084_abnormal_cardiac_muscle0.72622842
113MP0002269_muscular_atrophy0.70477325
114MP0003938_abnormal_ear_development0.70404134
115MP0002161_abnormal_fertility/fecundity0.69700284
116MP0001727_abnormal_embryo_implantation0.68757071
117MP0005647_abnormal_sex_gland0.68544595
118MP0005551_abnormal_eye_electrophysiolog0.68060972
119MP0003656_abnormal_erythrocyte_physiolo0.67843199
120MP0003937_abnormal_limbs/digits/tail_de0.67667875
121MP0002970_abnormal_white_adipose0.67655650
122MP0000627_abnormal_mammary_gland0.66754459
123MP0003699_abnormal_female_reproductive0.66516490
124MP0002736_abnormal_nociception_after0.66482223
125MP0002098_abnormal_vibrissa_morphology0.66347919
126MP0008961_abnormal_basal_metabolism0.65729673
127MP0001853_heart_inflammation0.64909686
128MP0003936_abnormal_reproductive_system0.64259362
129MP0001919_abnormal_reproductive_system0.63874141
130MP0005501_abnormal_skin_physiology0.61400408
131MP0000703_abnormal_thymus_morphology0.60839562
132MP0000747_muscle_weakness0.60550653
133MP0001849_ear_inflammation0.60536262
134MP0001529_abnormal_vocalization0.60518239
135MP0001286_abnormal_eye_development0.60405632
136MP0009703_decreased_birth_body0.60104451
137MP0001986_abnormal_taste_sensitivity0.59287722
138MP0002092_abnormal_eye_morphology0.57928650
139MP0002722_abnormal_immune_system0.56177501
140MP0008789_abnormal_olfactory_epithelium0.55453963
141MP0000428_abnormal_craniofacial_morphol0.54776485
142MP0003861_abnormal_nervous_system0.53959414
143MP0005266_abnormal_metabolism0.52214707

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.70814267
2Breast hypoplasia (HP:0003187)5.17850006
3Cerebral hypomyelination (HP:0006808)5.14497967
4Carpal bone hypoplasia (HP:0001498)4.36102651
5Rough bone trabeculation (HP:0100670)4.02652393
6Oral leukoplakia (HP:0002745)3.85519360
7Abnormality of cells of the erythroid lineage (HP:0012130)3.64753551
8Increased CSF lactate (HP:0002490)3.54073832
9Patellar aplasia (HP:0006443)3.49108869
10Aplasia/Hypoplasia of the patella (HP:0006498)3.46541716
11Impulsivity (HP:0100710)3.42426716
12Abnormal number of erythroid precursors (HP:0012131)3.40525820
13Reticulocytopenia (HP:0001896)3.39721128
14Abnormality of the anterior horn cell (HP:0006802)3.39324009
15Degeneration of anterior horn cells (HP:0002398)3.39324009
16Colon cancer (HP:0003003)3.38546704
17Type II lissencephaly (HP:0007260)3.36913054
18Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.18866982
19Premature ovarian failure (HP:0008209)3.10399460
20Absent radius (HP:0003974)3.09717530
21Hypoplasia of the pons (HP:0012110)3.07969530
22Mitochondrial inheritance (HP:0001427)3.07188773
23CNS hypomyelination (HP:0003429)3.04174002
24Abnormal mitochondria in muscle tissue (HP:0008316)3.01441358
25Trismus (HP:0000211)3.00402022
26Acute necrotizing encephalopathy (HP:0006965)2.99514313
27Secondary amenorrhea (HP:0000869)2.98142802
28Selective tooth agenesis (HP:0001592)2.95841579
29Abnormality of the pons (HP:0007361)2.95458959
30Progressive muscle weakness (HP:0003323)2.91111285
31Absent forearm bone (HP:0003953)2.87457308
32Aplasia involving forearm bones (HP:0009822)2.87457308
33Hepatocellular necrosis (HP:0001404)2.87037010
34Abnormal trabecular bone morphology (HP:0100671)2.84026309
35Type I transferrin isoform profile (HP:0003642)2.83348320
36Macrocytic anemia (HP:0001972)2.83003441
37Abnormality of the labia minora (HP:0012880)2.81643810
38Aplastic anemia (HP:0001915)2.81579300
39Microretrognathia (HP:0000308)2.78778348
40Multiple enchondromatosis (HP:0005701)2.73176948
41Absent thumb (HP:0009777)2.72593753
42Ependymoma (HP:0002888)2.71499092
43Hepatic necrosis (HP:0002605)2.71272614
44Ureteral duplication (HP:0000073)2.67656642
45Supernumerary spleens (HP:0009799)2.66320699
46Neoplasm of the pancreas (HP:0002894)2.65340181
47Acute encephalopathy (HP:0006846)2.65110646
48Increased hepatocellular lipid droplets (HP:0006565)2.63076066
49Abnormal protein glycosylation (HP:0012346)2.61627539
50Abnormal glycosylation (HP:0012345)2.61627539
51Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.61627539
52Abnormal protein N-linked glycosylation (HP:0012347)2.61627539
53Reduced antithrombin III activity (HP:0001976)2.61542827
54Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.61331333
55Abnormality of alanine metabolism (HP:0010916)2.61331333
56Hyperalaninemia (HP:0003348)2.61331333
57Lactic acidosis (HP:0003128)2.61094375
58Abnormality of the preputium (HP:0100587)2.58422632
59Concave nail (HP:0001598)2.57677764
60Retinal dysplasia (HP:0007973)2.53364412
61Horseshoe kidney (HP:0000085)2.52832038
62Premature graying of hair (HP:0002216)2.52640492
63Meckel diverticulum (HP:0002245)2.47398901
64Breast carcinoma (HP:0003002)2.47066902
65Prostate neoplasm (HP:0100787)2.46879897
66Postnatal microcephaly (HP:0005484)2.43450737
67Abnormality of the umbilical cord (HP:0010881)2.42790869
68Septate vagina (HP:0001153)2.42457462
69Severe muscular hypotonia (HP:0006829)2.39803722
70Atrophy/Degeneration involving motor neurons (HP:0007373)2.39493989
71Cellular immunodeficiency (HP:0005374)2.39338626
72Bone marrow hypocellularity (HP:0005528)2.35093426
73Hyperglycinemia (HP:0002154)2.34175454
74Chromsome breakage (HP:0040012)2.33590543
75Abnormality of the ileum (HP:0001549)2.32001052
76Lipid accumulation in hepatocytes (HP:0006561)2.30984559
77IgG deficiency (HP:0004315)2.27297752
78Progressive macrocephaly (HP:0004481)2.26668874
79Sparse eyelashes (HP:0000653)2.26227044
80Chromosomal breakage induced by crosslinking agents (HP:0003221)2.26209800
81Delusions (HP:0000746)2.22480250
82Megaloblastic anemia (HP:0001889)2.21185179
83Hypokinesia (HP:0002375)2.17274321
84Personality changes (HP:0000751)2.16939901
85Abnormality of DNA repair (HP:0003254)2.16115546
86Pallor (HP:0000980)2.15724351
87Cleft eyelid (HP:0000625)2.13759162
88Death in infancy (HP:0001522)2.13581242
89Hypoplasia of the radius (HP:0002984)2.13434944
90Abnormality of chromosome stability (HP:0003220)2.10171746
91Aplasia/Hypoplasia of the uvula (HP:0010293)2.08702387
92Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.08365951
93Cerebellar dysplasia (HP:0007033)2.07404514
94Agnosia (HP:0010524)2.06792381
95Aplasia/Hypoplasia involving the musculature (HP:0001460)2.05857725
96Breast aplasia (HP:0100783)2.05129498
97Lissencephaly (HP:0001339)2.03420011
98Progressive inability to walk (HP:0002505)2.03261736
99Tongue fasciculations (HP:0001308)2.02475254
100Vacuolated lymphocytes (HP:0001922)2.01899616
101Increased intramyocellular lipid droplets (HP:0012240)2.01032161
102Myelodysplasia (HP:0002863)2.00875767
103Albinism (HP:0001022)2.00676938
104Hypergonadotropic hypogonadism (HP:0000815)1.99435300
105Irregular epiphyses (HP:0010582)1.99208241
106Hypoplasia of the capital femoral epiphysis (HP:0003090)1.99105000
107Sloping forehead (HP:0000340)1.98570987
108Tracheoesophageal fistula (HP:0002575)1.98094784
109Abnormal spermatogenesis (HP:0008669)1.97998698
110Progressive microcephaly (HP:0000253)1.96802923
1113-Methylglutaconic aciduria (HP:0003535)1.96637742
112Areflexia of lower limbs (HP:0002522)1.96598603
113Abnormality of the carotid arteries (HP:0005344)1.96302043
114Stenosis of the external auditory canal (HP:0000402)1.95773158
115Pendular nystagmus (HP:0012043)1.95128893
116Increased serum lactate (HP:0002151)1.95028089
117Cerebral edema (HP:0002181)1.94460801
118Pancytopenia (HP:0001876)1.94335790
119Congenital stationary night blindness (HP:0007642)1.94121420
120Aplasia/Hypoplasia of the breasts (HP:0010311)1.93991523
121Small intestinal stenosis (HP:0012848)1.92865825
122Duodenal stenosis (HP:0100867)1.92865825
123Aplasia/hypoplasia of the humerus (HP:0006507)1.92063622
124Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.92024461
125Decreased activity of mitochondrial respiratory chain (HP:0008972)1.92024461
126Renal cortical cysts (HP:0000803)1.91875413
127Brittle hair (HP:0002299)1.91798373
128Redundant skin (HP:0001582)1.91727144
129J-shaped sella turcica (HP:0002680)1.90825125
130Opisthotonus (HP:0002179)1.90767034
131Hyperglycinuria (HP:0003108)1.90605811
132Renal Fanconi syndrome (HP:0001994)1.89952375
133Pancreatic cysts (HP:0001737)1.89538813
134Medulloblastoma (HP:0002885)1.88327388
135Facial cleft (HP:0002006)1.87174698
136Triphalangeal thumb (HP:0001199)1.86030884
137Muscle fibrillation (HP:0010546)1.85547951
138Glioma (HP:0009733)1.84990472
139Microvesicular hepatic steatosis (HP:0001414)1.84764424
140Optic disc pallor (HP:0000543)1.84756852
141Lethargy (HP:0001254)1.84270094
142Unsteady gait (HP:0002317)1.83880015
143Cerebellar hypoplasia (HP:0001321)1.83727310
144Squamous cell carcinoma (HP:0002860)1.82744499
14511 pairs of ribs (HP:0000878)1.82120928
146Abnormal rod and cone electroretinograms (HP:0008323)1.81961518
147Myopathic facies (HP:0002058)1.81797643
148Aplasia/Hypoplasia of the sacrum (HP:0008517)1.81578374
149Entropion (HP:0000621)1.81303913
150Glossoptosis (HP:0000162)1.80575869
151Short thumb (HP:0009778)1.79018928
152Abnormality of glycolysis (HP:0004366)1.78916455
153Increased serum pyruvate (HP:0003542)1.78916455
154Shoulder girdle muscle weakness (HP:0003547)1.78293972
155Clubbing of toes (HP:0100760)1.77663638
156Poikiloderma (HP:0001029)1.77504086
157Inability to walk (HP:0002540)1.75120389
158CNS demyelination (HP:0007305)1.73029882
159Increased neuronal autofluorescent lipopigment (HP:0002074)1.71720006
160Amelogenesis imperfecta (HP:0000705)1.71361890
161Sclerocornea (HP:0000647)1.70750996

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB16.14757464
2VRK25.84117615
3WEE14.76302309
4TSSK63.74122468
5STK163.33368374
6EIF2AK13.19147814
7SMG13.04627481
8NUAK12.91311718
9EPHA22.65958351
10CDC72.62563675
11NME22.58337515
12PLK42.49569113
13NEK22.43162359
14TTK2.36264775
15ACVR1B2.22350997
16SRPK12.21374441
17NEK12.04912853
18AKT32.04780472
19PLK12.04521213
20ZAK2.00165806
21PNCK1.86473699
22PLK31.83415254
23DYRK31.82958605
24EIF2AK31.72910494
25TAOK31.68129335
26BRSK21.66368973
27TAF11.63298080
28MKNK11.56024612
29CDK71.50368206
30TESK11.45270158
31AURKA1.45043332
32VRK11.44640891
33MKNK21.42797897
34AURKB1.42766356
35BRAF1.39365043
36CCNB11.38098431
37CHEK21.37394502
38RPS6KB21.32015146
39TLK11.31622182
40MST41.30266897
41TESK21.25963540
42ARAF1.24894857
43ATR1.23582171
44PIM21.21347571
45WNK41.20977636
46MUSK1.20677610
47TRIM281.19420299
48BRSK11.15049572
49PRKCI1.09446834
50IKBKB1.06261477
51PHKG11.04416700
52PHKG21.04416700
53MAP2K71.04324310
54PDK41.01105487
55PDK31.01105487
56CHEK10.97120957
57MAP3K80.95667984
58TXK0.94829870
59DYRK20.93356899
60BCKDK0.93312358
61NME10.86888204
62PAK10.80895515
63SCYL20.80520516
64STK390.79339046
65PASK0.79222141
66PAK40.76626499
67LMTK20.76109668
68MAP2K20.75165287
69ALK0.75013672
70CDK40.73998233
71CDK20.73571242
72CHUK0.73087003
73PDK20.71588604
74MAPK110.70267920
75SIK30.69751839
76CSNK2A20.69098459
77EEF2K0.67531278
78MAP4K20.64562277
79RPS6KA40.64150541
80CSNK2A10.61858183
81TRIB30.61769078
82STK40.61454373
83EIF2AK20.61341947
84PIM10.60247214
85CDK190.59316485
86TGFBR10.58027769
87PINK10.57444997
88ATM0.57426745
89STK38L0.55662228
90IRAK30.54036284
91MAPKAPK30.53496664
92LATS20.53207687
93MELK0.52298590
94CSNK1E0.50354655
95CDK10.48205168
96ADRBK20.47499016
97CDK90.46758057
98BMPR1B0.45149790
99RPS6KA50.43102295
100WNK30.41739616
101KDR0.41328239
102SIK20.40181472
103CLK10.39690333
104CSNK1A1L0.39241798
105ILK0.38328863
106RAF10.38200216
107CDK120.35382798
108ABL20.34649081
109FRK0.34608308
110AKT20.34564779
111STK100.33813044
112MAP3K40.32243114
113MAP2K60.32130458
114CSNK1G30.31584076
115MTOR0.31235691
116DAPK10.29408668
117CSNK1G10.27213777
118MST1R0.25747044
119BRD40.24010735
120TAOK20.23318982
121STK240.23126642
122DAPK30.21047323
123PRKDC0.20914116
124LIMK10.19796419
125MAPKAPK50.19689972
126CDK30.19347727
127STK30.19345958
128MAP3K110.19309422
129CAMKK20.18592528
130CDK80.18478614
131PBK0.18137954
132MATK0.17788686
133CDK11A0.16995485
134MAPK90.13596748
135CDK150.12199243

Predicted pathways (KEGG)

RankGene SetZ-score
1RNA polymerase_Homo sapiens_hsa030204.38615972
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.25043354
3DNA replication_Homo sapiens_hsa030304.23706122
4Proteasome_Homo sapiens_hsa030504.17448971
5Mismatch repair_Homo sapiens_hsa034303.74982257
6Ribosome_Homo sapiens_hsa030103.59593952
7RNA transport_Homo sapiens_hsa030133.25379557
8Vitamin B6 metabolism_Homo sapiens_hsa007503.18191013
9Spliceosome_Homo sapiens_hsa030403.13047732
10Homologous recombination_Homo sapiens_hsa034402.79010120
11Pyrimidine metabolism_Homo sapiens_hsa002402.78704762
12Base excision repair_Homo sapiens_hsa034102.77243414
13Nucleotide excision repair_Homo sapiens_hsa034202.68716948
14Cell cycle_Homo sapiens_hsa041102.48221339
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.46441783
16Basal transcription factors_Homo sapiens_hsa030222.13887819
17Fanconi anemia pathway_Homo sapiens_hsa034601.92219377
18One carbon pool by folate_Homo sapiens_hsa006701.76898524
19Folate biosynthesis_Homo sapiens_hsa007901.75912031
20Purine metabolism_Homo sapiens_hsa002301.67520582
21RNA degradation_Homo sapiens_hsa030181.63771407
22p53 signaling pathway_Homo sapiens_hsa041151.60007728
23Sulfur metabolism_Homo sapiens_hsa009201.49853960
24Non-homologous end-joining_Homo sapiens_hsa034501.48996905
25mRNA surveillance pathway_Homo sapiens_hsa030151.42933913
26Fatty acid elongation_Homo sapiens_hsa000621.39102876
27Regulation of autophagy_Homo sapiens_hsa041401.30352811
28Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.30310691
29Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.30112852
30Cysteine and methionine metabolism_Homo sapiens_hsa002701.26486858
31Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.23270776
32Epstein-Barr virus infection_Homo sapiens_hsa051691.22150746
33Pentose phosphate pathway_Homo sapiens_hsa000301.19510548
34Steroid biosynthesis_Homo sapiens_hsa001001.18333300
35Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.13545147
36Oocyte meiosis_Homo sapiens_hsa041141.09717652
37Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.06357424
38Primary immunodeficiency_Homo sapiens_hsa053401.05482075
39Sulfur relay system_Homo sapiens_hsa041221.04806393
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.01599495
41Biosynthesis of amino acids_Homo sapiens_hsa012300.99847917
42Huntingtons disease_Homo sapiens_hsa050160.94562170
43Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.92992608
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.88427377
45Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.85478449
46Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.84143999
472-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.80188695
48Fructose and mannose metabolism_Homo sapiens_hsa000510.79523903
49Drug metabolism - other enzymes_Homo sapiens_hsa009830.78983902
50Parkinsons disease_Homo sapiens_hsa050120.76695650
51Butanoate metabolism_Homo sapiens_hsa006500.73146483
52Oxidative phosphorylation_Homo sapiens_hsa001900.66975525
53Carbon metabolism_Homo sapiens_hsa012000.63744320
54Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.60732872
55Glycerophospholipid metabolism_Homo sapiens_hsa005640.59895986
56Glutathione metabolism_Homo sapiens_hsa004800.59339500
57Phototransduction_Homo sapiens_hsa047440.56430617
58Protein export_Homo sapiens_hsa030600.54760141
59Propanoate metabolism_Homo sapiens_hsa006400.54106573
60Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.53739823
61Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.53068589
62Viral carcinogenesis_Homo sapiens_hsa052030.52711132
63Sphingolipid metabolism_Homo sapiens_hsa006000.49867808
64Systemic lupus erythematosus_Homo sapiens_hsa053220.48387678
65SNARE interactions in vesicular transport_Homo sapiens_hsa041300.47503197
66Lysine degradation_Homo sapiens_hsa003100.47502372
67Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.46496215
68Pyruvate metabolism_Homo sapiens_hsa006200.46064771
69Metabolic pathways_Homo sapiens_hsa011000.46026565
70Selenocompound metabolism_Homo sapiens_hsa004500.45536446
71Antigen processing and presentation_Homo sapiens_hsa046120.45312161
72Herpes simplex infection_Homo sapiens_hsa051680.45163420
73Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.43850010
74Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.41660370
75Thyroid cancer_Homo sapiens_hsa052160.40747422
76Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40680413
77Fatty acid metabolism_Homo sapiens_hsa012120.39986170
78Cyanoamino acid metabolism_Homo sapiens_hsa004600.39377933
79HTLV-I infection_Homo sapiens_hsa051660.37283379
80Glycosaminoglycan degradation_Homo sapiens_hsa005310.35977669
81Peroxisome_Homo sapiens_hsa041460.35858516
82Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.33204000
83Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.33136906
84Hippo signaling pathway_Homo sapiens_hsa043900.32786105
85Vitamin digestion and absorption_Homo sapiens_hsa049770.32599991
86Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.32496383
87Arginine and proline metabolism_Homo sapiens_hsa003300.32364452
88Vibrio cholerae infection_Homo sapiens_hsa051100.31721406
89Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.31648007
90Lysosome_Homo sapiens_hsa041420.27396190
91Arachidonic acid metabolism_Homo sapiens_hsa005900.26960178
92Galactose metabolism_Homo sapiens_hsa000520.26744960
93RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.26027541
94Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.23908017
95Collecting duct acid secretion_Homo sapiens_hsa049660.22991904
96Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.22222878
97Tryptophan metabolism_Homo sapiens_hsa003800.22022790
98Linoleic acid metabolism_Homo sapiens_hsa005910.19577708
99Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.19216157
100Tight junction_Homo sapiens_hsa045300.18521705
101Apoptosis_Homo sapiens_hsa042100.18269265
102Notch signaling pathway_Homo sapiens_hsa043300.17768032
103Alzheimers disease_Homo sapiens_hsa050100.16312331
104Inositol phosphate metabolism_Homo sapiens_hsa005620.15186273
105Small cell lung cancer_Homo sapiens_hsa052220.15153925
106N-Glycan biosynthesis_Homo sapiens_hsa005100.14667502
107HIF-1 signaling pathway_Homo sapiens_hsa040660.14442033
108Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.13410117
109Colorectal cancer_Homo sapiens_hsa052100.12580306
110T cell receptor signaling pathway_Homo sapiens_hsa046600.12225743
111Hedgehog signaling pathway_Homo sapiens_hsa043400.12177190
112Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.12120335
113Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.10245509
114Acute myeloid leukemia_Homo sapiens_hsa052210.09866939
115Melanoma_Homo sapiens_hsa052180.09670215
116MicroRNAs in cancer_Homo sapiens_hsa052060.09577310
117Basal cell carcinoma_Homo sapiens_hsa052170.07884034
118FoxO signaling pathway_Homo sapiens_hsa040680.07825074
119mTOR signaling pathway_Homo sapiens_hsa041500.07263716
120Alcoholism_Homo sapiens_hsa050340.07203483
121Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.06737388
122Central carbon metabolism in cancer_Homo sapiens_hsa052300.06459485
123TGF-beta signaling pathway_Homo sapiens_hsa043500.06311949
124Legionellosis_Homo sapiens_hsa051340.05257456
125Renin-angiotensin system_Homo sapiens_hsa046140.04983241
126Pathways in cancer_Homo sapiens_hsa052000.03081857
127alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.02939362
128Bladder cancer_Homo sapiens_hsa052190.02936192
129Cardiac muscle contraction_Homo sapiens_hsa042600.02320318
130Shigellosis_Homo sapiens_hsa05131-0.0144472
131Transcriptional misregulation in cancer_Homo sapiens_hsa05202-0.0133113
132Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250-0.0063957

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